id
stringlengths
1
5
tokens
sequence
ner_tags
sequence
2601
[ "No", "evidence", "for", "the", "expression", "of", "the", "progesterone", "receptor", "on", "peripheral", "blood", "lymphocytes", "during", "pregnancy", "[", "see", "comments", "]" ]
[ 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 7, 8, 8, 0, 0, 0, 0, 0, 0 ]
2602
[ "The", "expression", "of", "the", "progesterone", "receptor", "in", "human", "peripheral", "blood", "lymphocytes", "was", "analysed", ",", "using", "an", "enzyme", "linked", "immunosorbent", "assay", "(", "Abbott", "PgR-EIA", "monoclonal", ")", ",", "in", "order", "to", "evaluate", "its", "prognostic", "character", "in", "the", "context", "of", "spontaneous", "abortion", "." ]
[ 0, 0, 0, 0, 9, 10, 0, 7, 8, 8, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
2603
[ "Cytosols", "were", "prepared", "from", "lymphocytes", "of", "24", "healthy", "pregnant", "women", "(", "11", "first", ",", "10", "second", "and", "three", "third", "trimester", ")", ",", "seven", "healthy", "non-pregnant", "women", ",", "nine", "women", "with", "recurrent", "spontaneous", "abortion", ",", "and", "six", "healthy", "men", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
2604
[ "In", "addition", ",", "a", "human", "breast", "carcinoma", "cell", "line", "(", "ZR-75-1", ")", ",", "which", "expresses", "the", "progesterone", "receptor", ",", "was", "analysed", "throughout", "." ]
[ 0, 0, 0, 0, 5, 6, 6, 6, 6, 0, 5, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0 ]
2605
[ "The", "ZR-75-1", "cell", "line", "showed", "an", "expression", "of", "642", "fmol/mg", "whereas", "lymphocytes", "of", "pregnant", "women", "showed", "an", "expression", "<", "or", "=", "4", "fmol/mg", "." ]
[ 0, 5, 6, 6, 0, 0, 0, 0, 0, 0, 0, 7, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
2606
[ "Lymphocytes", "of", "non-pregnant", "women", ",", "women", "with", "threatened", "pre-term", "delivery", ",", "and", "men", "showed", "equivalent", "levels", ":", "3", "+/-", "1", ",", "3", "+/-", "2", "and", "5", "+/-", "4", "fmol/mg", "respectively", "." ]
[ 7, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
2607
[ "These", "results", "show", "that", "there", "is", "no", "evidence", "of", "specific", "expression", "of", "the", "progesterone", "receptor", "in", "pregnancy", "and", "exclude", "any", "prognostic", "character", "in", "spontaneous", "abortion", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
2608
[ "A", "role", "for", "the", "progesterone", "receptor", "in", "the", "mechanism", "of", "the", "known", "effect", "of", "progesterone", "on", "peripheral", "blood", "lymphocytes", "is", "also", "excluded", "." ]
[ 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 8, 0, 0, 0, 0 ]
2609
[ "Tolerance", "to", "lipopolysaccharide", "involves", "mobilization", "of", "nuclear", "factor", "kappa", "B", "with", "predominance", "of", "p50", "homodimers", "." ]
[ 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 0, 0, 0, 9, 10, 0 ]
2610
[ "Stimulation", "of", "the", "human", "monocytic", "cell", "line", "Mono", "Mac", "6", "with", "lipopolysaccharide", "(", "LPS", ")", "leads", "to", "rapid", "and", "transient", "expression", "of", "cytokines", "like", "tumor", "necrosis", "factor", "(", "TNF", ")", "." ]
[ 0, 0, 0, 5, 6, 6, 6, 6, 6, 6, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 9, 0, 0 ]
2611
[ "When", "such", "cells", "are", "precultured", "for", "2", "days", "with", "a", "low", "dose", "of", "LPS", "(", "20", "ng/ml", ")", "followed", "by", "stimulation", "with", "a", "high", "dose", "of", "LPS", "(", "1", "microgram/ml", ")", ",", "expression", "of", "the", "TNF", "gene", "is", "minimal", ",", "i.e.", "the", "cells", "are", "tolerant", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
2612
[ "In", "nuclear", "run-on", "analysis", ",", "such", "tolerant", "cells", "show", "only", "a", "low", "degree", "of", "transcription", ",", "indicating", "that", "tolerance", "operates", "at", "or", "upstream", "of", "the", "transcription", "level", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
2613
[ "The", "CD14", "LPS", "receptor", "is", ",", "however", ",", "up-regulated", "(", "not", "down-regulated", ")", "in", "tolerant", "cells", ",", "and", "LPS", "can", ",", "in", "fact", ",", "still", "lead", "to", "activation", "of", "tolerant", "cells", "as", "evidenced", "by", "mobilization", "of", "the", "transcription", "factor", "nuclear", "factor", "kappa", "B", "(", "NF-kappa", "B", ")", "." ]
[ 0, 9, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 10, 10, 0, 9, 10, 0, 0 ]
2614
[ "Resolution", "of", "the", "NF-kappa", "B", "complex", "in", "gel", "shift", "analysis", "shows", "that", "the", "binding", "protein", ",", "mobilized", "in", "naive", "Mono", "Mac", "6", "cells", ",", "consists", "mainly", "of", "p50-p65", "heterodimers", ",", "while", "in", "tolerant", "cells", ",", "the", "p50", "homodimer", "is", "predominant", "." ]
[ 0, 0, 0, 9, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 6, 6, 6, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0 ]
2615
[ "This", "increase", "in", "p50", "homodimers", "coincides", "with", "an", "increase", "in", "p105", "mRNA", ",", "suggestive", "of", "a", "transcriptional", "up-regulation", "of", "p50", "." ]
[ 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 3, 4, 0, 0, 0, 0, 0, 0, 0, 9, 0 ]
2616
[ "Reporter", "gene", "analysis", "reveals", "that", "the", "NF-kappa", "B", "complex", "mobilized", "in", "tolerant", "cells", "is", "functionally", "inactive", "in", "that", "NF-kappa", "B-dependent", "luciferase", "constructs", "containing", "the", "human", "immunodeficiency", "virus", "long", "terminal", "repeat", "or", "the", "TNF", "5'-region", "show", "only", "minimal", "transactivation", "after", "LPS", "stimulation", "." ]
[ 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 2, 0, 0, 1, 2, 2, 2, 2, 2, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0 ]
2617
[ "Similar", "to", "Mono", "Mac", "6", "cells", ",", "primary", "blood", "monocytes", ",", "when", "precultured", "with", "a", "low", "dose", "of", "LPS", ",", "also", "become", "tolerant", "and", "produce", "little", "TNF", "after", "LPS", "stimulation", "." ]
[ 0, 0, 5, 6, 6, 6, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0 ]
2618
[ "The", "tolerant", "blood", "monocytes", "also", "up-regulate", "CD14", ",", "and", "they", "mobilize", "NF-kappa", "B", "with", "a", "predominance", "of", "p50", "homodimers", "." ]
[ 0, 0, 7, 8, 0, 0, 9, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 9, 10, 0 ]
2619
[ "Taken", "together", ",", "these", "results", "demonstrate", "that", "tolerance", "to", "LPS", "is", "determined", "by", "post-receptor", "mechanisms", "that", "involve", "an", "altered", "composition", "of", "the", "NF-kappa", "B", "complex", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0 ]
2620
[ "Analysis", "of", "Oct2-isoform", "expression", "in", "lipopolysaccharide-stimulated", "B", "lymphocytes", "." ]
[ 0, 0, 9, 0, 0, 0, 7, 8, 0 ]
2621
[ "Oct2-isoform", "expression", "in", "splenic", "B", "cells", "stimulated", "with", "lipopolysaccharide", "or", "lipopolysaccharide", "plus", "phorbol-di-butyrate", "was", "analysed", "by", "cDNA", "cloning", "." ]
[ 9, 0, 0, 7, 8, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
2622
[ "The", "frequency", "of", "Oct2-positive", "clones", "was", "1/15", ",", "000", "in", "both", "libraries", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
2623
[ "Two", "new", "isoforms", "were", "found", "that", "generate", "novel", "amino-", "or", "carboxy-terminal", "sequences", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
2624
[ "An", "isoform", "lacking", "exon", "11", "destroyed", "the", "carboxy-terminal", "leucin-zipper", "region", "and", "introduced", "a", "frame", "shift", "creating", "a", "novel", ",", "proline-rich", "carboxy", "terminus", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
2625
[ "A", "new", "exon", "containing", "a", "highly", "basic", "region", "(", "4c", ")", "was", "characterized", ",", "between", "exons", "4", "and", "5", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
2626
[ "This", "exon", "was", "inserted", "between", "glutamine-rich", "regions", "2", "and", "3", ",", "carboxy", "terminal", "of", "a", "tentative", "leucine-zipper", "structure", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
2627
[ "In", "addition", ",", "a", "new", "combination", "isoform", "containing", "Oct2a", "'s", "amino", "terminal", "insert", "(", "exon", "7a", ")", "and", "Oct2b", "'s", "carboxy", "terminal", "insert", "(", "exon", "13", ")", "was", "found", "that", "created", "a", "novel", "large", "isoform", ",", "Oct2ab", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0 ]
2628
[ "More", "frequent", "use", "of", "the", "classical", "Oct2a", "and", "Oct2b", "isoforms", "was", "observed", "in", "the", "lipopolysaccharide-stimulated", "B", "cells", ",", "while", "a", "preference", "for", "the", "Oct2ab", "and", "Oct2ba", "isoforms", "was", "observed", "in", "lipopolysaccharide", "plus", "phorbol-di-butyrate-treated", "cells", "." ]
[ 0, 0, 0, 0, 0, 0, 9, 0, 9, 10, 0, 0, 0, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 9, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0 ]
2629
[ "Positive", "regulators", "of", "the", "lineage-specific", "transcription", "factor", "GATA-1", "in", "differentiating", "erythroid", "cells", "." ]
[ 0, 0, 0, 0, 0, 9, 10, 10, 0, 0, 7, 8, 0 ]
2630
[ "The", "zinc", "finger", "transcription", "factor", "GATA-1", "is", "a", "major", "regulator", "of", "gene", "expression", "in", "erythroid", ",", "megakaryocyte", ",", "and", "mast", "cell", "lineages", "." ]
[ 0, 9, 10, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 7, 0, 7, 0, 0, 7, 8, 8, 0 ]
2631
[ "GATA-1", "binds", "to", "WGATAR", "consensus", "motifs", "in", "the", "regulatory", "regions", "of", "virtually", "all", "erythroid", "cell-specific", "genes", "." ]
[ 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 0, 0, 0 ]
2632
[ "Analyses", "with", "cultured", "cells", "and", "cell-free", "systems", "have", "provided", "strong", "evidence", "that", "GATA-1", "is", "involved", "in", "control", "of", "globin", "gene", "expression", "during", "erythroid", "differentiation", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 1, 2, 0, 0, 7, 0, 0 ]
2633
[ "Targeted", "mutagenesis", "of", "the", "GATA-1", "gene", "in", "embryonic", "stem", "cells", "has", "demonstrated", "its", "requirement", "in", "normal", "erythroid", "development", "." ]
[ 0, 0, 0, 0, 1, 2, 0, 7, 8, 8, 0, 0, 0, 0, 0, 0, 7, 0, 0 ]
2634
[ "Efficient", "rescue", "of", "the", "defect", "requires", "an", "intact", "GATA", "element", "in", "the", "distal", "promoter", ",", "suggesting", "autoregulatory", "control", "of", "GATA-1", "transcription", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0 ]
2635
[ "To", "examine", "whether", "GATA-1", "expression", "involves", "additional", "regulatory", "factors", "or", "is", "maintained", "entirely", "by", "an", "autoregulatory", "loop", ",", "we", "have", "used", "a", "transient", "heterokaryon", "system", "to", "test", "the", "ability", "of", "erythroid", "factors", "to", "activate", "the", "GATA-1", "gene", "in", "nonerythroid", "nuclei", "." ]
[ 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0 ]
2636
[ "We", "show", "here", "that", "proerythroblasts", "and", "mature", "erythroid", "cells", "contain", "a", "diffusible", "activity", "(", "TAG", ")", "capable", "of", "transcriptional", "activation", "of", "GATA-1", "and", "that", "this", "activity", "decreases", "during", "the", "terminal", "differentiation", "of", "erythroid", "cells", "." ]
[ 0, 0, 0, 0, 7, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0 ]
2637
[ "Nuclei", "from", "GATA-1", "-mutant", "embryonic", "stem", "cells", "can", "still", "be", "reprogrammed", "to", "express", "their", "globin", "genes", "in", "erythroid", "heterokaryons", ",", "indicating", "that", "de", "novo", "induction", "of", "GATA-1", "is", "not", "required", "for", "globin", "gene", "activation", "following", "cell", "fusion", "." ]
[ 0, 0, 9, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 7, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0 ]
2638
[ "Role", "of", "HIV-1", "Nef", "expression", "in", "activation", "pathways", "in", "CD4", "+", "T", "cells", "." ]
[ 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0 ]
2639
[ "The", "role", "of", "the", "human", "immunodeficiency", "virus", "(", "HIV-1", ")", "Nef", "protein", "in", "T", "cell", "activation", "pathways", "was", "investigated", "using", "a", "Jurkat", "CD4+", "cell", "line", "stably", "transfected", "with", "a", "Nef", "expression", "vector", "." ]
[ 0, 0, 0, 0, 9, 10, 10, 10, 10, 10, 10, 10, 0, 7, 8, 0, 0, 0, 0, 0, 0, 5, 6, 6, 6, 0, 0, 0, 0, 0, 0, 0, 0 ]
2640
[ "Secretion", "of", "IL-2", "and", "TNF-alpha", ",", "surface", "expression", "of", "IL-2R", ",", "and", "DNA-binding", "activity", "of", "NF-kappa", "B", "and", "AP-1", "(", "Fos/Jun", ")", "complex", "in", "response", "to", "phorbol", "myristate", "acetate", ",", "TNF-alpha", ",", "or", "immobilized", "antibodies", "to", "CD3", "were", "monitored", "." ]
[ 0, 0, 9, 0, 9, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 9, 10, 0, 9, 10, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 9, 0, 0, 0 ]
2641
[ "These", "parameters", "were", "not", "modified", "by", "Nef", "expression", "in", "Jurkat", "cells", ",", "whereas", "stimulation", "with", "the", "same", "stimuli", "resulted", "in", "partial", "inhibition", "of", "LTR", "activation", "in", "Nef+", "Jurkat", "cells", "." ]
[ 0, 0, 0, 0, 0, 0, 9, 0, 0, 5, 6, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 6, 0 ]
2642
[ "This", "inhibition", "was", "not", "mediated", "through", "Nef", "phosphorylation", "on", "Thr-15", "or", "GTP-binding", "activity", "because", "mutations", "in", "critical", "sites", "did", "not", "alter", "this", "inhibition", "." ]
[ 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
2643
[ "Analysis", "of", "truncated", "LTRs", "confirmed", "that", "inhibition", "of", "LTR", "activation", "was", "not", "mediated", "through", "NF-kappa", "B", "-binding", "activity", "but", "through", "the", "region", "containing", "the", "negative", "responding", "elements", "(", "NREs", ")", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 0, 1, 0, 0 ]
2644
[ "These", "results", "suggest", "that", "Nef", "downmodulates", "LTR", "activation", "without", "significantly", "inhibiting", "the", "capacity", "of", "T", "cells", "to", "respond", "to", "immunological", "activations", "." ]
[ 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0 ]
2645
[ "Tat-binding", "protein", "7", "is", "a", "subunit", "of", "the", "26S", "protease", "." ]
[ 9, 10, 10, 0, 0, 0, 0, 0, 9, 10, 0 ]
2646
[ "Subunit", "6", "(", "S6", ")", ",", "an", "integral", "component", "of", "the", "26S", "protease", "from", "human", "erythrocytes", ",", "has", "been", "studied", "by", "SDS-PAGE", ",", "peptide", "mapping", "and", "sequence", "analysis", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
2647
[ "S6", "was", "cleaved", "with", "CNBr", "and", "three", "internal", "peptides", "were", "sequenced", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
2648
[ "A", "comparison", "with", "known", "proteins", "in", "Genbank", "revealed", "that", "all", "three", "S6", "peptides", "match", "the", "predicted", "sequence", "of", "TBP7", ",", "Tat-binding", "protein", "7", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 9, 10, 10, 0 ]
2649
[ "Based", "on", "peptide", "matches", "covering", "more", "than", "10", "%", "of", "the", "TBP7", "sequence", ",", "and", "the", "fact", "that", "the", "migration", "of", "S6", "on", "SDS-PAGE", "is", "consistent", "with", "the", "estimated", "molecular", "mass", "for", "TBP7", ",", "we", "conclude", "that", "subunit", "6", "of", "the", "26S", "protease", "is", "TBP7", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 9, 0 ]
2650
[ "Hypoxia", "causes", "the", "activation", "of", "nuclear", "factor", "kappa", "B", "through", "the", "phosphorylation", "of", "I", "kappa", "B", "alpha", "on", "tyrosine", "residues", "." ]
[ 0, 0, 0, 0, 0, 9, 10, 10, 10, 0, 0, 0, 0, 9, 10, 10, 10, 0, 0, 0, 0 ]
2651
[ "The", "response", "of", "mammalian", "cells", "to", "stress", "is", "controlled", "by", "transcriptional", "regulatory", "proteins", "such", "as", "nuclear", "factor", "kappa", "B", "(", "NF-kappa", "B", ")", "to", "induce", "a", "wide", "variety", "of", "early", "response", "genes", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
2652
[ "In", "this", "report", ",", "we", "show", "that", "exposure", "of", "cells", "to", "hypoxia", "(", "0.02", "%", "O2", ")", "results", "in", "I", "kappa", "B", "alpha", "degradation", ",", "increased", "NF-kappa", "B", "DNA", "binding", "activity", ",", "and", "transactivation", "of", "a", "reporter", "gene", "construct", "containing", "two", "NF-kappa", "B", "DNA", "binding", "sites", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 2, 2, 0 ]
2653
[ "Pretreatment", "of", "cells", "with", "protein", "tyrosine", "kinase", "inhibitors", "and", "the", "dominant", "negative", "allele", "of", "c-Raf-1", "(", "Raf", "301", ")", "inhibited", "I", "kappa", "B", "alpha", "degradation", ",", "NF-kappa", "B", "binding", ",", "and", "transactivation", "of", "kappa", "B", "reporter", "constructs", "by", "hypoxia", "." ]
[ 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 1, 0, 1, 2, 0, 0, 9, 10, 10, 10, 0, 0, 9, 10, 0, 0, 0, 0, 0, 1, 2, 2, 2, 0, 0, 0 ]
2654
[ "To", "demonstrate", "a", "direct", "link", "between", "changes", "in", "the", "phosphorylation", "pattern", "of", "I", "kappa", "B", "alpha", "with", "NF-kappa", "B", "activation", ",", "we", "immunoprecipitated", "I", "kappa", "B", "alpha", "after", "varying", "times", "of", "hypoxic", "exposure", "and", "found", "that", "its", "tyrosine", "phosphorylation", "status", "increased", "during", "hypoxic", "exposure", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 0, 9, 10, 0, 0, 0, 0, 9, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
2655
[ "Inhibition", "of", "the", "transfer", "of", "tyrosine", "phosphoryl", "groups", "onto", "I", "kappa", "B", "alpha", "prevented", "I", "kappa", "B", "alpha", "degradation", "and", "NF-kappa", "B", "binding", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 0, 9, 10, 10, 10, 0, 0, 9, 10, 0, 0 ]
2656
[ "In", "comparison", "to", "other", "activators", "of", "NF-kappa", "B", "such", "as", "phorbol", "myristate", "acetate", "or", "tumor", "necrosis", "factor", ",", "we", "did", "not", "detect", "changes", "in", "the", "tyrosine", "phosphorylation", "status", "of", "I", "kappa", "B", "alpha", "following", "treatment", "with", "either", "of", "these", "agents", "." ]
[ 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0 ]
2657
[ "These", "results", "suggest", "that", "tyrosine", "phosphorylation", "of", "I", "kappa", "B", "alpha", "during", "hypoxia", "is", "an", "important", "proximal", "step", "which", "precedes", "its", "dissociation", "and", "degradation", "from", "NF-kappa", "B", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0 ]
2658
[ "Overproduction", "of", "NFKB2", "(", "lyt-10", ")", "and", "c-Rel", ":", "a", "mechanism", "for", "HTLV-I", "Tax", "-mediated", "trans-activation", "via", "the", "NF-kappa", "B", "signalling", "pathway", "." ]
[ 0, 0, 9, 0, 9, 0, 0, 9, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 9, 10, 0, 0, 0 ]
2659
[ "Molecular", ",", "biochemical", "and", "epidemiological", "evidence", "implicate", "HTLV-I", "as", "an", "etiologic", "agent", "of", "adult", "T", "cell", "leukemia", "(", "ATL", ")", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
2660
[ "The", "Tax", "protein", "of", "HTLV-I", ",", "a", "positive", "transcriptional", "activator", "of", "HTLV-I", "gene", "expression", ",", "is", "a", "viral", "oncogene", "that", "also", "increases", "transcription", "of", "cellular", "genes", "including", "GM-CSF", ",", "IL-2R", "alpha", "and", "IL-2", "." ]
[ 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 9, 10, 0, 9, 0 ]
2661
[ "One", "of", "the", "cellular", "targets", "of", "the", "trans-activating", "effects", "of", "Tax", "is", "the", "NF-kappa", "B/Rel", "family", "of", "transcription", "factors", ",", "pleiotropic", "regulators", "of", "immunoregulatory", ",", "cytokine", "and", "viral", "gene", "expression", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 9, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
2662
[ "In", "this", "report", ",", "we", "demonstrate", "that", "NFKB2", "(", "lyt-10", ")", "and", "c-Rel", "are", "overexpressed", "in", "HTLV-I", "infected", "and", "Tax-expressing", "cells", "and", ",", "together", ",", "account", "for", "the", "majority", "of", "the", "constitutive", "NF-kappa", "B", "binding", "activity", "in", "these", "cells", "before", "and", "after", "PMA", "stimulation", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 9, 0, 9, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
2663
[ "Most", "importantly", ",", "we", "show", "a", "Tax", "-dependent", "correlation", "between", "expression", "of", "NFKB2", "(", "p100", ")", "and", "processing", "to", "the", "DNA", "binding", "NFKB2", "(", "p52", ")", "form", ",", "induction", "of", "c-Rel", ",", "and", "trans-activation", "of", "NF-kappa", "B", "-mediated", "gene", "expression", "." ]
[ 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 9, 0, 9, 0, 0, 0, 0, 0, 0, 0, 9, 0, 9, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 1, 2, 2, 2, 0, 0 ]
2664
[ "Furthermore", ",", "the", "NFKB2", "precursor", "is", "physically", "associated", "with", "c-Rel", "and", "with", "Tax", "in", "HTLV-I", "infected", "cells", "." ]
[ 0, 0, 0, 9, 0, 0, 0, 0, 0, 9, 0, 0, 9, 0, 0, 0, 0, 0 ]
2665
[ "We", "propose", "that", "NFKB2", "synthesis", "and", "processing", "allows", "continuous", "nuclear", "expression", "of", "an", "otherwise", "cytoplasmic", "protein", "and", ",", "in", "conjunction", "with", "overexpression", "of", "c-Rel", ",", "NFKB2", "alters", "the", "NF-kappa", "B", "signalling", "pathway", "and", "contributes", "to", "leukemic", "transformation", "of", "T", "cells", "by", "HTLV-I", "." ]
[ 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 9, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0, 0, 0 ]
2666
[ "Retinoic", "acid", "downmodulates", "erythroid", "differentiation", "and", "GATA1", "expression", "in", "purified", "adult-progenitor", "culture", "." ]
[ 0, 0, 0, 7, 0, 0, 9, 0, 0, 0, 0, 0, 0 ]
2667
[ "All-trans", "retinoic", "acid", "(", "RA", ")", "is", "an", "important", "morphogen", "in", "vertebrate", "development", ",", "a", "normal", "constituent", "in", "human", "adult", "blood", "and", "is", "also", "involved", "in", "the", "control", "of", "cell", "growth", "and", "differentiation", "in", "acute", "promyelocytic", "leukemia", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
2668
[ "We", "have", "examined", "the", "effects", "of", "RA", "on", "normal", "hematopoiesis", "by", "using", "early", "hematopoietic", "progenitor", "cells", "(", "HPC", ")", "stringently", "purified", "from", "adult", "peripheral", "blood", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 8, 0, 7, 0, 0, 0, 0, 0, 0, 0, 0 ]
2669
[ "In", "clonogenetic", "fetal", "calf", "serum-supplemented", "(", "FCS+", ")", "or", "-nonsupplemented", "(", "FCS-", ")", "culture", "treated", "with", "saturating", "levels", "of", "interleukin-3", "(", "IL-3", ")", "granulocyte-macrophage", "colony-stimulating", "factor", "(", "GM-CSF", ")", "and", "erythropoietin", "(", "Ep", ")", "(", "combined", "with", "c-kit", "ligand", "in", "FCS", "(", "-", ")", "-culture", "conditions", ")", ",", "RA", "induces", "a", "dramatic", "dose-dependent", "shift", "from", "erythroid", "to", "granulomonocytic", "colony", "formation", ",", "the", "latter", "colonies", "being", "essentially", "represented", "by", "granulocytic", "clones", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 9, 0, 9, 10, 10, 0, 9, 0, 0, 9, 0, 9, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 6, 0 ]
2670
[ "This", "shift", "is", "apparently", "not", "caused", "by", "a", "recruitment", "phenomenon", ",", "because", "in", "FCS+", "culture", ",", "the", "total", "number", "of", "colonies", "is", "not", "significantly", "modified", "by", "RA", "addition", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
2671
[ "In", "FCS-", "liquid-suspension", "culture", "supplemented", "with", "saturating", "Ep", "level", "and", "low-dose", "IL-3/GM-CSF", ",", "adult", "HPC", "undergo", "unilineage", "erythropoietic", "differentiation", ":", "Here", "again", ",", "treatment", "with", "high-dose", "RA", "induces", "a", "shift", "from", "the", "erythroid", "to", "granulocytic", "differentiation", "pathway", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 9, 0, 0, 7, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 0, 0, 0, 0, 0 ]
2672
[ "Studies", "on", "RA", "time-response", "or", "pulse", "treatment", "in", "semisolid", "or", "liquid", "culture", "show", "that", "early", "RA", "addition", "is", "most", "effective", ",", "thus", "indicating", "that", "early", "but", "not", "late", "HPC", "are", "sensitive", "to", "its", "action", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 0, 0, 0, 0, 0, 0 ]
2673
[ "We", "then", "analyzed", "the", "expression", "of", "the", "master", "GATA1", "gene", ",", "which", "encodes", "a", "finger", "transcription", "factor", "required", "for", "normal", "erythroid", "development", ";", "addition", "of", "RA", "to", "HPC", "stimulated", "into", "unilineage", "erythropoietic", "differentiation", "in", "liquid", "culture", "caused", "a", "virtually", "complete", "inhibition", "of", "GATA1", "mRNA", "induction", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 0, 0, 0, 0, 0, 0, 7, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 4, 0, 0 ]
2674
[ "These", "results", "indicate", "that", "RA", "directly", "inhibits", "the", "erythroid", "differentiation", "program", "at", "the", "level", "of", "early", "adult", "HPC", ",", "and", "may", "lead", "to", "a", "shift", "from", "the", "erythroid", "to", "granulocytic", "differentiation", "pathway", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 7, 0, 0, 0, 0, 0, 0, 0, 0, 7, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 0, 0, 0, 0, 0 ]
2675
[ "This", "phenomenon", "is", "correlated", "with", "inhibition", "of", "GATA1", "induction", "in", "the", "early", "stages", "of", "erythropoietic", "differentiation", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
2676
[ "Induction", "of", "phosphatidylinositol", "turnover", "and", "EGR-1", "mRNA", "expression", "by", "crosslinking", "of", "surface", "IgM", "and", "IgD", "in", "the", "human", "B", "cell", "line", "B104", "." ]
[ 0, 0, 0, 0, 0, 3, 4, 0, 0, 0, 0, 0, 9, 0, 9, 0, 0, 5, 6, 6, 6, 6, 0 ]
2677
[ "We", "have", "previously", "shown", "that", "a", "human", "B", "lymphoma", "cell", "line", ",", "B104", ",", "expressed", "surface", "IgM", "(", "sIgM", ")", "and", "surface", "IgD", "(", "sIgD", ")", ",", "and", "that", "crosslinking", "of", "sIgM", "and", "sIgD", "by", "anti-IgM", "antibody", "(", "Ab", ")", "and", "anti-IgD", "Ab", ",", "respectively", ",", "induced", "Ca2+", "influx", "to", "almost", "the", "same", "degree", ",", "whereas", "only", "sIgM", "-crosslinking", "caused", "B104", "cell", "death", "." ]
[ 0, 0, 0, 0, 0, 0, 5, 6, 6, 6, 6, 0, 5, 0, 0, 9, 10, 0, 9, 0, 0, 9, 10, 0, 9, 0, 0, 0, 0, 0, 0, 9, 0, 9, 0, 9, 10, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 5, 6, 0, 0 ]
2678
[ "Here", ",", "we", "investigated", "the", "accumulation", "of", "cyclic", "AMP", "(", "cAMP", ")", ",", "the", "hydrolysis", "of", "inositol", "phosphates", ",", "protein", "kinase", "C", "(", "PKC", ")", "activity", "and", "the", "induction", "of", "Egr-1", "and", "c-fos", "mRNA", "expression", "by", "sIgM-", "and", "sIgD-crosslinking", "to", "examine", "differences", "in", "the", "signals", "mediated", "through", "sIgM", "and", "sIgD", "in", "B104", "cells", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 9, 0, 0, 0, 0, 0, 0, 3, 0, 3, 4, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 9, 0, 5, 6, 0 ]
2679
[ "Both", "sIgM-", "and", "sIgD-crosslinking", "with", "antibodies", "induced", "elevation", "of", "cAMP", "levels", ",", "phosphatidylinositol", "turnover", ",", "PKC", "activation", "and", "expression", "of", "Egr-1", "and", "c-fos", "mRNA", ",", "although", "sIgM", "-crosslinking", "was", "more", "effective", "than", "sIgD", "-crosslinking", ",", "presumably", "due", "to", "the", "higher", "expression", "of", "sIgM", "than", "of", "sIgD", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 3, 0, 3, 4, 0, 0, 9, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 9, 0 ]
2680
[ "Egr-1", "mRNA", "expression", "induced", "by", "sIgM-", "and", "sIgD-crosslinking", "was", "inhibited", "by", "H7", ",", "erbstatin", "and", "genistein", ",", "but", "not", "by", "HA1004", "." ]
[ 3, 4, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
2681
[ "Erbstatin", "and", "genistein", "inhibited", "the", "sIg-crosslinking-induced", "Egr-1", "mRNA", "expression", "in", "a", "dose-dependent", "manner", "parallel", "to", "that", "observed", "in", "the", "inhibition", "of", "sIg-crosslinking-induced", "protein", "tyrosine", "phosphorylation", "." ]
[ 0, 0, 0, 0, 0, 0, 3, 4, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
2682
[ "Phorbol", "myristate", "acetate", "induced", "Egr-1", "mRNA", "expression", "but", "forskolin", "and", "dibutyryl", "cyclic", "AMP", "did", "not", "." ]
[ 0, 0, 0, 0, 3, 4, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
2683
[ "These", "findings", "suggest", "that", "the", "Egr-1", "mRNA", "activating", "signals", "through", "sIgM", "and", "sIgD", "are", "protein", "tyrosine", "kinase-", "and", "PKC-dependent", ",", "but", "protein", "kinase", "A", "-independent", "." ]
[ 0, 0, 0, 0, 0, 3, 4, 0, 0, 0, 9, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 0 ]
2684
[ "Cyclosporin", "A", "(", "CsA", ")", "and", "FK506", "rescued", "B104", "cells", "from", "death", "induced", "by", "anti-IgM", "Ab", ",", "but", "did", "not", "affect", "the", "expression", "of", "Egr-1", "and", "c-fos", "mRNA", ",", "showing", "that", "CsA", "and", "FK506", "affect", "signal", "transducers", "differently", "from", "or", "downstream", "to", "these", "molecules", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 5, 6, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 3, 4, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
2685
[ "The", "difference", "in", "signals", "transduced", "through", "sIgM", "and", "sIgD", "in", "B104", "cells", "is", "discussed", "." ]
[ 0, 0, 0, 0, 0, 0, 9, 0, 9, 0, 5, 6, 0, 0, 0 ]
2686
[ "Direct", "exposure", "to", "2", ",", "3", ",", "7", ",", "8-tetrachlorodibenzo-p-dioxin", "(", "TCDD", ")", "increases", "infectivity", "of", "human", "erythrocytes", "to", "a", "malarial", "parasite", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0, 0, 0, 0, 0 ]
2687
[ "Direct", "exposure", "to", "10", "nM", "2", ",", "3", ",", "7", ",", "8-TCDD", "caused", "a", "75", "%", "increase", "and", "a", "2-fold", "increase", "in", "the", "infectivity", "of", "isolated", "human", "erythrocytes", "to", "P.", "falciparum", "after", "48", "hours", "when", "the", "parasites", "were", "in", "an", "unsynchronized", "or", "synchronized", "state", "of", "growth", ",", "respectively", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
2688
[ "Treatment", "of", "human", "erythrocytes", "with", "10", "microM", "sodium", "orthovanadate", "(", "NaOV", ")", ",", "an", "inhibitor", "of", "plasma", "membrane", "Ca-ATPase", "and", "phosphotyrosine", "phosphatase", ",", "decreased", "parasitemia", "by", "30", "%", "." ]
[ 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0 ]
2689
[ "Co-treatment", "of", "RBCs", "with", "TCDD", "and", "NaOV", "completely", "blocked", "the", "TCDD-induced", "increase", "in", "parasitemia", "." ]
[ 0, 0, 7, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
2690
[ "Because", "erythrocytes", "are", "anucleated", ",", "these", "results", "are", "discussed", "as", "evidence", "for", "biochemical", "changes", "by", "TCDD", "without", "requiring", "the", "activation", "of", "gene", "products", "." ]
[ 0, 7, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
2691
[ "Evidence", "for", "a", "trans-acting", "activator", "function", "regulating", "the", "expression", "of", "the", "human", "CD5", "antigen", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0 ]
2692
[ "Interspecies", "somatic", "cell", "hybrids", "were", "generated", "by", "fusing", "the", "mouse", "T-lymphoma", "cell", "line", ",", "BW5147", ",", "with", "normal", "human", "T", "lymphocytes", "at", "different", "stages", "of", "differentiation", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 6, 6, 6, 0, 5, 0, 0, 0, 7, 8, 8, 0, 0, 0, 0, 0, 0 ]
2693
[ "Thymocytes", ",", "activated", "peripheral", "T", "lymphocytes", ",", "or", "an", "activated", "T-cell", "clone", "were", "used", "as", "human", "partners", ",", "respectively", ",", "in", "three", "independent", "fusions", "." ]
[ 7, 0, 0, 7, 8, 8, 0, 0, 0, 0, 5, 6, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
2694
[ "Irrespective", "of", "the", "human", "cell", "partner", "used", "for", "fusion", ",", "a", "certain", "number", "of", "hybrids", "lost", "CD5", "surface", "expression", "over", "a", "period", "of", "time", "in", "culture", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
2695
[ "Analysis", "at", "the", "phenotype", "and", "genetic", "level", "showed", "that", "lack", "of", "CD5", "expression", "was", "due", "neither", "to", "segregation", "of", "human", "autosome", "11", ",", "on", "which", "the", "CD5", "gene", "has", "been", "mapped", ",", "nor", "to", "deletion", "of", "the", "CD5", "structural", "gene", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 0 ]
2696
[ "Furthermore", ",", "loss", "of", "CD5", "surface", "expression", "correlated", "with", "the", "absence", "of", "specific", "mRNA", "." ]
[ 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
2697
[ "Since", "these", "hybrids", "preferentially", "segregate", "human", "chromosomes", ",", "these", "results", "indicate", "the", "existence", "of", "a", "non-syntenic", "trans-active", "locus", ",", "or", "loci", ",", "positively", "controlling", "the", "expression", "of", "the", "human", "CD5", "gene", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 0 ]
2698
[ "Induction", "of", "the", "CD11b", "gene", "during", "activation", "of", "the", "monocytic", "cell", "line", "U937", "requires", "a", "novel", "nuclear", "factor", "MS-2", "[", "published", "erratum", "appears", "in", "J", "Immunol", "1999", "Jul", "15", ";", "163", "(", "2", ")", ":", "1091", "]" ]
[ 0, 0, 0, 1, 2, 0, 0, 0, 0, 5, 6, 6, 6, 0, 0, 0, 9, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
2699
[ "The", "differentiation", "of", "myeloid", "precursors", "into", "mature", "myelomonocytic", "cells", "is", "characterized", "by", "the", "induction", "of", "the", "gene", "encoding", "the", "beta2", "integrin", "CD11b", "." ]
[ 0, 0, 0, 7, 8, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0 ]
2700
[ "The", "transcription", "factors", "Sp1", "and", "PU.1", "prime", "the", "CD11b", "promoter", ",", "but", "the", "nature", "of", "the", "factors", "responsible", "for", "its", "inducible", "expression", "are", "unknown", "." ]
[ 0, 9, 10, 10, 0, 9, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]