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17401
[ "Elevated", "glucocorticoid", "receptor", "concentrations", "before", "and", "after", "glucocorticoid", "therapy", "in", "peripheral", "mononuclear", "leukocytes", "of", "patients", "with", "atopic", "dermatitis", "." ]
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17402
[ "The", "number", "and", "affinity", "of", "glucocorticoid", "binding", "sites", "in", "peripheral", "mononuclear", "leukocytes", "of", "patients", "with", "atopic", "dermatitis", "(", "AD", ")", "and", "healthy", "controls", "were", "determined", "under", "baseline", "conditions", "and", "after", "a", "defined", "oral", "glucocorticoid", "treatment", "." ]
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17403
[ "Patients", "with", "AD", "(", "n", "=", "15", ")", "exhibited", "significantly", "more", "glucocorticoid", "receptors", "(", "GR", ")", "per", "cell", "than", "the", "control", "group", "(", "n", "=", "22", ")", ",", "while", "the", "GR", "affinity", "did", "not", "differ", "." ]
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17404
[ "Methylprednisolone", "treatment", "resulted", "in", "a", "significant", "reduction", "of", "the", "GR", "sites", "per", "cell", "in", "the", "steroid-treated", "control", "group", "(", "n", "=", "10", ")", "in", "contrast", "to", "the", "patients", "." ]
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17405
[ "The", "dissociation", "constant", "was", "not", "affected", "by", "methylprednisolone", "treatment", "in", "either", "group", "." ]
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17406
[ "In", "view", "of", "the", "therapeutic", "efficiency", "of", "glucocorticoids", "in", "AD", "and", "findings", "of", "abnormal", "cAMP", "and", "cAMP-phosphodiesterase", "activity", ",", "the", "elevated", "GR", "concentrations", "in", "AD", "lend", "support", "to", "the", "hypothesis", "of", "a", "compensatory", "GR", "upregulation", "due", "to", "an", "insufficient", "action", "of", "endogenous", "cortisol", "or", "to", "altered", "cAMP-induced", "GR", "expression", "." ]
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17407
[ "The", "actions", "of", "cyclosporin", "A", "and", "FK506", "suggest", "a", "novel", "step", "in", "the", "activation", "of", "T", "lymphocytes", "." ]
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17408
[ "Cyclosporin", "A", "and", "FK506", "are", "immunosuppressive", "compounds", "that", "have", "similar", "inhibitory", "effects", "on", "the", "expression", "of", "several", "lymphokines", "produced", "by", "T", "lymphocytes", "." ]
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17409
[ "Despite", "their", "similar", "effects", "the", "drugs", "bind", "to", "two", "different", "cytosolic", "protein", ",", "cyclophilin", "and", "FKBP", "respectively", ",", "which", "raises", "the", "possibility", "that", "they", "have", "different", "modes", "of", "action", "." ]
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17410
[ "Using", "constructs", "in", "which", "mRNA", "production", "controlled", "by", "a", "specific", "transcription", "factor", "could", "be", "readily", "measured", "we", "found", "that", "both", "cyclosporin", "A", "and", "FK506", "completely", "inhibited", "transcription", "activated", "by", "NF-AT", ",", "NFIL2", "A", ",", "NFIL2", "B", "and", "partially", "inhibited", "transcription", "activated", "by", "NF", "kappa", "B", "." ]
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17411
[ "Cyclosporin", "A", "and", "FK506", "inhibited", "only", "transcriptional", "activation", "that", "was", "dependent", "on", "Ca2+", "mobilization", "." ]
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17412
[ "However", ",", "cyclosporin", "A", "and", "FK506", "did", "not", "inhibit", "Ca2+", "mobilization", "dependent", "expression", "of", "c-fos", "mRNA", "indicating", "that", "only", "a", "subset", "of", "signalling", "pathways", "regulated", "by", "Ca2+", "is", "sensitive", "to", "these", "drugs", "." ]
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17413
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17414
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17415
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17416
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17417
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17418
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17419
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17420
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17421
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17422
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17423
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17424
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17425
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17426
[ "In", "lymphocytes", ",", "the", "octamer-binding", "protein", "Oct-2A", "and", "variants", "thereof", "are", "thought", "to", "contribute", "to", "the", "B-cell", "specific", "gene", "expression", ",", "while", "the", "ubiquitous", "protein", "Oct-1", "seems", "to", "control", "general", "octamer", "site", "-dependent", "transcription", "." ]
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17427
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17428
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17429
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17430
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17431
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17432
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17433
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17434
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17435
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17436
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17437
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17438
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17439
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17440
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17441
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17442
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17443
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17444
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17445
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17446
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17447
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17448
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17449
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17450
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17451
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17452
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17454
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17455
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17456
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17457
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17458
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17459
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17460
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17461
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17462
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17463
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17464
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17465
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17466
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17467
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17468
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17469
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17470
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17471
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17472
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17473
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17474
[ "Effects", "of", "aldosterone", "on", "intralymphocytic", "sodium", "and", "potassium", "in", "patients", "with", "essential", "hypertension", "." ]
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17475
[ "In", "vitro", "binding", "of", "aldosterone", "to", "mineralocorticoid", "receptors", "on", "human", "mononuclear", "leukocytes", "(", "HML", ")", "and", "its", "effects", "on", "the", "intracellular", "sodium", "and", "potassium", "concentrations", "of", "HML", "have", "already", "been", "described", "." ]
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17476
[ "In", "the", "present", "paper", "this", "easily", "accessible", "human", "cell", "model", "was", "investigated", "in", "13", "patients", "with", "essential", "hypertension", "." ]
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17477
[ "In", "only", "four", "patients", "sodium", "in", "HML", "without", "incubation", "was", "elevated", "compared", "with", "the", "range", "for", "normal", "persons", "." ]
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17478
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17479
[ "The", "addition", "of", "1.4", "nM", "aldosterone", "did", "not", "prevent", "this", "loss", "of", "electrolytes", "as", "observed", "in", "normal", "persons", "." ]
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17480
[ "Plasma", "renin", "activity", "and", "aldosterone", "were", "not", "correlated", "with", "the", "electrolyte", "response", "and", "were", "within", "the", "normal", "limits", "." ]
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17481
[ "The", "number", "of", "mineralocorticoid", "receptors", "/cell", "were", "within", "or", "close", "to", "the", "normal", "range", "(", "n", "=", "9", ")", "." ]
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17482
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17483
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17484
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17485
[ "It", "is", "proposed", "that", "the", "character", "of", "their", "expression", "under", "the", "influence", "of", "vitamin", "D", "may", "be", "used", "with", "differential", "diagnostic", "purposes", "in", "view", "." ]
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17486
[ "Regulation", "of", "gene", "expression", "with", "double-stranded", "phosphorothioate", "oligonucleotides", "." ]
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17487
[ "Alteration", "of", "gene", "transcription", "by", "inhibition", "of", "specific", "transcriptional", "regulatory", "proteins", "is", "necessary", "for", "determining", "how", "these", "factors", "participate", "in", "cellular", "differentiation", "." ]
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17488
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17489
[ "Inhibition", "of", "sequence-specific", "DNA-binding", "proteins", "was", "achieved", "with", "double-stranded", "(", "ds", ")", "phosphorothioate", "oligonucleotides", "that", "contained", "octamer", "or", "kappa", "B", "consensus", "sequences", "." ]
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17490
[ "The", "phosphorothioate", "oligonucleotides", "specifically", "bound", "either", "octamer", "transcription", "factor", "or", "nuclear", "factor", "(", "NF", ")", "-kappa", "B", "." ]
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17491
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17492
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17493
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17494
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17495
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17496
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17497
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17498
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17499
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17500
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