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17201
[ "Tandem", "AP-1-binding", "sites", "within", "the", "human", "beta-globin", "dominant", "control", "region", "function", "as", "an", "inducible", "enhancer", "in", "erythroid", "cells", "." ]
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17202
[ "A", "powerful", "enhancer", "has", "been", "mapped", "to", "an", "18-bp", "DNA", "segment", "located", "11", "kb", "5", "'", "to", "the", "human", "epsilon-globin", "gene", "within", "the", "dominant", "control", "or", "locus-activating", "region", "." ]
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17203
[ "This", "enhancer", "is", "inducible", "in", "K562", "human", "erythroleukemia", "cells", ",", "increasing", "linked", "gamma-globin", "promoter", "/luciferase", "gene", "expression", "to", "170-fold", "over", "an", "enhancerless", "construct", "." ]
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17204
[ "The", "enhancer", "consists", "of", "tandem", "AP-1-binding", "sites", ",", "phased", "10", "bp", "apart", ",", "which", "are", "both", "required", "for", "full", "activity", "." ]
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17205
[ "DNA-protein", "binding", "assays", "with", "nuclear", "extracts", "from", "induced", "cells", "demonstrate", "a", "high", "molecular", "weight", "complex", "on", "the", "enhancer", "." ]
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17206
[ "The", "formation", "of", "this", "complex", "also", "requires", "both", "AP-1", "sites", "and", "correlates", "with", "maximal", "enhancer", "activity", "." ]
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17207
[ "Induction", "of", "the", "enhancer", "may", "have", "a", "role", "in", "the", "increase", "in", "globin", "gene", "transcription", "that", "characterizes", "erythroid", "maturation", "." ]
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17208
[ "Enhancer", "activity", "appears", "to", "be", "mediated", "by", "the", "binding", "of", "a", "complex", "of", "proteins", "from", "the", "jun", "and", "fos", "families", "to", "tandem", "AP-1", "consensus", "sequences", "." ]
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17209
[ "Identification", "of", "a", "novel", "factor", "that", "interacts", "with", "an", "immunoglobulin", "heavy-chain", "promoter", "and", "stimulates", "transcription", "in", "conjunction", "with", "the", "lymphoid", "cell-specific", "factor", "OTF2", "." ]
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17210
[ "The", "tissue-specific", "expression", "of", "the", "MOPC", "141", "immunoglobulin", "heavy-chain", "gene", "was", "studied", "by", "using", "in", "vitro", "transcription", "." ]
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17211
[ "B-cell-specific", "transcription", "of", "this", "gene", "was", "dependent", "on", "the", "octamer", "element", "5'-ATGCAAAG-3", "'", ",", "located", "in", "the", "upstream", "region", "of", "this", "promoter", "and", "in", "the", "promoters", "of", "all", "other", "immunoglobulin", "heavy-", "and", "light-chain", "genes", "." ]
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17212
[ "The", "interaction", "of", "purified", "octamer", "transcription", "factors", "1", "and", "2", "(", "OTF1", "and", "OTF2", ")", "with", "the", "MOPC", "141", "promoter", "was", "studied", "by", "using", "electrophoretic", "mobility", "shift", "assays", "and", "DNase", "I", "footprinting", "." ]
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17213
[ "Purified", "OTF1", "from", "HeLa", "cells", "and", "OTF1", "and", "OTF2", "from", "B", "cells", "bound", "to", "identical", "sequences", "within", "the", "heavy-chain", "promoter", "." ]
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17214
[ "The", "OTF", "interactions", "we", "observed", "extended", "over", "the", "heptamer", "element", "5'-CTCAGGA-3", "'", ",", "and", "it", "seems", "likely", "that", "the", "binding", "of", "the", "purified", "factors", "involves", "cooperation", "between", "octamer", "and", "heptamer", "sites", "in", "this", "promoter", "." ]
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17215
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17216
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17217
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17218
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17219
[ "NF-kappa", "B", "as", "inducible", "transcriptional", "activator", "of", "the", "granulocyte-macrophage", "colony-stimulating", "factor", "gene", "." ]
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17220
[ "The", "expression", "of", "the", "gene", "encoding", "the", "granulocyte-macrophage", "colony-stimulating", "factor", "(", "GM-CSF", ")", "is", "induced", "upon", "activation", "of", "T", "cells", "with", "phytohemagglutinin", "and", "active", "phorbolester", "and", "upon", "expression", "of", "tax1", ",", "a", "transactivating", "protein", "of", "the", "human", "T-cell", "leukemia", "virus", "type", "I", "." ]
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17221
[ "The", "same", "agents", "induce", "transcription", "from", "the", "interleukin-2", "receptor", "alpha-chain", "and", "interleukin-2", "genes", ",", "depending", "on", "promoter", "elements", "that", "bind", "the", "inducible", "transcription", "factor", "NF-kappa", "B", "(", "or", "an", "NF-kappa", "B-like", "factor", ")", "." ]
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17222
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17223
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17224
[ "Using", "electrophoretic", "mobility", "shift", "assays", ",", "we", "showed", "binding", "of", "purified", "human", "NF-kappa", "B", "and", "of", "the", "NF-kappa", "B", "activated", "in", "Jurkat", "T", "cells", "to", "an", "oligonucleotide", "comprising", "the", "GM-CSF", "promoter", "element", "responsible", "for", "mediating", "responsiveness", "to", "T-cell-activating", "signals", "and", "tax1", "." ]
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17225
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17226
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17227
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17228
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17229
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17230
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17231
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17232
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17233
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17234
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17235
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17236
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17237
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17238
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17239
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17240
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17241
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17242
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17243
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17244
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17245
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17246
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17247
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17248
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17249
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17250
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