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17101
[ "In", "order", "to", "investigate", "this", "possibility", ",", "we", "measured", "the", "concentration", "of", "VDR", "in", "PHA-activated", "peripheral", "mononuclear", "cells", "from", "10", "XLH", "patients", "." ]
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17102
[ "Patients", "without", "phosphate", "supplementation", "showed", "significantly", "lower", "concentration", "(", "21.7", "+/-", "5.1", "fmol/mg", "protein", ",", "mean", "+/-", "SEM", ")", "compared", "to", "the", "normal", "controls", "(", "60.7", "+/-", "4.0", ")", "." ]
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17103
[ "On", "the", "contrary", ",", "there", "was", "no", "significant", "difference", "between", "the", "phosphate-supplemented", "patients", "(", "58.3", "+/-", "2.7", ")", "and", "controls", "." ]
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17104
[ "There", "was", "a", "significant", "positive", "correlation", "between", "VDR", "concentration", "and", "serum", "phosphate", "(", "P", "less", "than", "0.05", ")", "." ]
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17105
[ "In", "two", "patients", ",", "VDR", "was", "increased", "after", "daily", "phosphate", "supplementation", "was", "started", "." ]
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17106
[ "These", "results", "indicate", "that", "a", "decreased", "concentration", "of", "VDR", "secondary", "to", "persistent", "hypophosphatemia", "is", "one", "of", "the", "causes", "of", "vitamin", "D", "resistance", "in", "XLH", "." ]
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17107
[ "Two", "distinct", "forms", "of", "active", "transcription", "factor", "CREB", "(", "cAMP", "response", "element", "binding", "protein", ")", "." ]
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17108
[ "Mammalian", "cells", "express", "two", "distinct", "forms", "of", "transcription", "factor", "CREB", "(", "cAMP", "response", "element", "binding", "protein", ")", "that", "are", "apparently", "the", "products", "of", "alternative", "splicing", "of", "the", "CREB", "gene", "transcript", "." ]
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17109
[ "The", "two", "proteins", "differ", "by", "a", "14-amino", "acid", "serine-rich", "insertion", "present", "in", "one", "of", "the", "CREB", "isoforms", "." ]
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17110
[ "We", "show", "that", "both", "CREB", "isoforms", "are", "expressed", "in", "many", "cell", "types", "and", "mammalian", "species", "." ]
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17111
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17112
[ "As", "expected", "for", "proteins", "of", "this", "class", ",", "the", "CREB", "proteins", "bind", "DNA", "as", "dimers", "." ]
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17113
[ "Both", "proteins", "impart", "cAMP-regulated", "transcriptional", "activity", "to", "a", "heterologous", "DNA-binding", "domain", ",", "showing", "that", "cAMP", "directly", "modulates", "the", "transcriptional", "stimulatory", "activity", "of", "CREB", "." ]
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17114
[ "The", "presence", "of", "multiple", "CREB", "isoforms", "with", "identical", "DNA-binding", "specificities", "but", "differences", "in", "the", "presumed", "regulatory", "domain", "raises", "the", "possibility", "that", "CREB", "proteins", "may", "be", "able", "to", "integrate", "distinct", "regulatory", "signals", "at", "the", "level", "of", "gene", "transcription", "." ]
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17115
[ "Human", "immunodeficiency", "virus", "vpr", "product", "is", "a", "virion-associated", "regulatory", "protein", "." ]
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17116
[ "The", "vpr", "product", "of", "the", "human", "immunodeficiency", "virus", "type", "1", "(", "HIV-1", ")", "acts", "in", "trans", "to", "accelerate", "virus", "replication", "and", "cytopathic", "effect", "in", "T", "cells", "." ]
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17117
[ "Here", "it", "is", "shown", "that", "the", "HIV-1", "viral", "particle", "contains", "multiple", "copies", "of", "the", "vpr", "protein", "." ]
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17118
[ "The", "vpr", "product", "is", "the", "first", "regulatory", "protein", "of", "HIV-1", "to", "be", "found", "in", "the", "virus", "particle", "." ]
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17119
[ "This", "observation", "raises", "the", "possibility", "that", "vpr", "acts", "to", "facilitate", "the", "early", "steps", "of", "infection", "before", "de", "novo", "viral", "protein", "synthesis", "occurs", "." ]
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17120
[ "A", "novel", "B-cell", "lineage-specific", "transcription", "factor", "present", "at", "early", "but", "not", "late", "stages", "of", "differentiation", "." ]
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17121
[ "A", "novel", "B-cell-specific", "transcription", "factor", ",", "BSAP", ",", "was", "identified", "as", "a", "mammalian", "homolog", "of", "the", "sea", "urchin", "protein", "TSAP", ",", "which", "interacts", "with", "the", "promoters", "of", "four", "tissue-specific", "late", "histone", "H2A-2", "and", "H2B-2", "genes", "." ]
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17122
[ "As", "shown", "by", "mobility-shift", ",", "methylation", "interference", ",", "and", "mutational", "analyses", ",", "the", "mammalian", "protein", "BSAP", "recognizes", "all", "four", "sea", "urchin", "binding", "sites", "in", "a", "manner", "indistinguishable", "from", "TSAP", ";", "however", ",", "the", "two", "proteins", "differ", "in", "molecular", "weight", "." ]
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17123
[ "BSAP", "is", "exclusively", "restricted", "to", "the", "B-cell", "lineage", "of", "lymphoid", "differentiation", "." ]
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17124
[ "Its", "expression", "appears", "to", "be", "activated", "during", "pro-B-cell", "development", ",", "is", "abundant", "at", "the", "pre-B-", "and", "mature", "B-cell", "stages", ",", "but", "is", "absent", "in", "terminally", "differentiated", "plasma", "cells", "." ]
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17125
[ "Moreover", ",", "BSAP", "is", "clearly", "a", "B-cell-specific", "transcription", "factor", ",", "as", "a", "wild-type", "but", "not", "a", "mutant", "TSAP-binding", "site", "of", "the", "sea", "urchin", "functions", "only", "in", "transfected", "B", "cells", "as", "an", "upstream", "promoter", "element", "." ]
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17126
[ "Competition", "experiments", "did", "not", "reveal", "any", "high-affinity", "binding", "site", "for", "BSAP", "in", "known", "regulatory", "regions", "of", "immunoglobulin", "and", "class", "II", "major", "histocompatibility", "(", "MHC", ")", "genes", ",", "suggesting", "that", "BSAP", "is", "a", "regulator", "of", "a", "different", "set", "of", "B-lymphoid-specific", "genes", "." ]
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17127
[ "Octamer", "transcription", "factors", "and", "the", "cell", "type-specificity", "of", "immunoglobulin", "gene", "expression", "." ]
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17128
[ "Antibodies", "are", "produced", "exclusively", "in", "B", "lymphocytes", "." ]
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17129
[ "The", "expression", "of", "the", "antibody-encoding", "genes", ",", "the", "immunoglobulin", "(", "Ig", ")", "genes", ",", "is", "also", "restricted", "to", "B", "cells", "." ]
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17130
[ "The", "octamer", "sequence", "ATGCAAAT", "is", "present", "in", "the", "promoter", "and", "the", "enhancer", "of", "Ig", "genes", ",", "and", "plays", "an", "important", "role", "in", "its", "tissue-specific", "expression", "." ]
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17131
[ "This", "sequence", "motif", "is", "a", "binding", "site", "for", "nuclear", "proteins", ",", "the", "so-called", "octamer", "transcription", "factors", "(", "Oct", "or", "OTF", "factors", ")", "." ]
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17132
[ "The", "Oct-1", "protein", "is", "present", "in", "all", "cell", "types", "analyzed", "so", "far", ",", "whereas", "Oct-2A", "and", "Oct-2B", "are", "found", "mainly", "in", "B", "lymphocytes", "." ]
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17133
[ "All", "three", "proteins", "show", "the", "same", "sequence", "specificity", "and", "binding", "affinity", "." ]
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17134
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17135
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17136
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17137
[ "A", "factor", "known", "to", "bind", "to", "endogenous", "Ig", "heavy", "chain", "enhancer", "only", "in", "lymphocytes", "is", "a", "ubiquitously", "active", "transcription", "factor", "." ]
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17138
[ "The", "transcriptional", "enhancer", "located", "in", "the", "first", "intron", "of", "the", "immunoglobulin", "heavy", "chain", "constant", "region", "is", "a", "major", "determinant", "of", "B-cell-specific", "expression", "of", "immunoglobulin", "genes", "." ]
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17139
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17140
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17141
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17142
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17143
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17144
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17145
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17146
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17147
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17148
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17149
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17150
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17151
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17152
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17153
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17154
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17155
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