id
stringlengths 1
5
| tokens
sequence | ner_tags
sequence |
---|---|---|
17101 | [
"In",
"order",
"to",
"investigate",
"this",
"possibility",
",",
"we",
"measured",
"the",
"concentration",
"of",
"VDR",
"in",
"PHA-activated",
"peripheral",
"mononuclear",
"cells",
"from",
"10",
"XLH",
"patients",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
0,
7,
8,
8,
0,
0,
0,
0,
0
] |
17102 | [
"Patients",
"without",
"phosphate",
"supplementation",
"showed",
"significantly",
"lower",
"concentration",
"(",
"21.7",
"+/-",
"5.1",
"fmol/mg",
"protein",
",",
"mean",
"+/-",
"SEM",
")",
"compared",
"to",
"the",
"normal",
"controls",
"(",
"60.7",
"+/-",
"4.0",
")",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
17103 | [
"On",
"the",
"contrary",
",",
"there",
"was",
"no",
"significant",
"difference",
"between",
"the",
"phosphate-supplemented",
"patients",
"(",
"58.3",
"+/-",
"2.7",
")",
"and",
"controls",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
17104 | [
"There",
"was",
"a",
"significant",
"positive",
"correlation",
"between",
"VDR",
"concentration",
"and",
"serum",
"phosphate",
"(",
"P",
"less",
"than",
"0.05",
")",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
17105 | [
"In",
"two",
"patients",
",",
"VDR",
"was",
"increased",
"after",
"daily",
"phosphate",
"supplementation",
"was",
"started",
"."
] | [
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
17106 | [
"These",
"results",
"indicate",
"that",
"a",
"decreased",
"concentration",
"of",
"VDR",
"secondary",
"to",
"persistent",
"hypophosphatemia",
"is",
"one",
"of",
"the",
"causes",
"of",
"vitamin",
"D",
"resistance",
"in",
"XLH",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
17107 | [
"Two",
"distinct",
"forms",
"of",
"active",
"transcription",
"factor",
"CREB",
"(",
"cAMP",
"response",
"element",
"binding",
"protein",
")",
"."
] | [
0,
0,
0,
0,
0,
9,
10,
10,
0,
9,
10,
10,
10,
10,
0,
0
] |
17108 | [
"Mammalian",
"cells",
"express",
"two",
"distinct",
"forms",
"of",
"transcription",
"factor",
"CREB",
"(",
"cAMP",
"response",
"element",
"binding",
"protein",
")",
"that",
"are",
"apparently",
"the",
"products",
"of",
"alternative",
"splicing",
"of",
"the",
"CREB",
"gene",
"transcript",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
9,
10,
10,
0,
9,
10,
10,
10,
10,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
3,
4,
4,
0
] |
17109 | [
"The",
"two",
"proteins",
"differ",
"by",
"a",
"14-amino",
"acid",
"serine-rich",
"insertion",
"present",
"in",
"one",
"of",
"the",
"CREB",
"isoforms",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
0
] |
17110 | [
"We",
"show",
"that",
"both",
"CREB",
"isoforms",
"are",
"expressed",
"in",
"many",
"cell",
"types",
"and",
"mammalian",
"species",
"."
] | [
0,
0,
0,
0,
9,
10,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
17111 | [
"Both",
"encode",
"proteins",
"that",
"bind",
"specifically",
"to",
"a",
"cAMP",
"response",
"element",
"in",
"vitro",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
2,
0,
0,
0
] |
17112 | [
"As",
"expected",
"for",
"proteins",
"of",
"this",
"class",
",",
"the",
"CREB",
"proteins",
"bind",
"DNA",
"as",
"dimers",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
0,
0,
0,
0,
0
] |
17113 | [
"Both",
"proteins",
"impart",
"cAMP-regulated",
"transcriptional",
"activity",
"to",
"a",
"heterologous",
"DNA-binding",
"domain",
",",
"showing",
"that",
"cAMP",
"directly",
"modulates",
"the",
"transcriptional",
"stimulatory",
"activity",
"of",
"CREB",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0
] |
17114 | [
"The",
"presence",
"of",
"multiple",
"CREB",
"isoforms",
"with",
"identical",
"DNA-binding",
"specificities",
"but",
"differences",
"in",
"the",
"presumed",
"regulatory",
"domain",
"raises",
"the",
"possibility",
"that",
"CREB",
"proteins",
"may",
"be",
"able",
"to",
"integrate",
"distinct",
"regulatory",
"signals",
"at",
"the",
"level",
"of",
"gene",
"transcription",
"."
] | [
0,
0,
0,
0,
9,
10,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
17115 | [
"Human",
"immunodeficiency",
"virus",
"vpr",
"product",
"is",
"a",
"virion-associated",
"regulatory",
"protein",
"."
] | [
9,
10,
10,
10,
10,
0,
0,
0,
0,
0,
0
] |
17116 | [
"The",
"vpr",
"product",
"of",
"the",
"human",
"immunodeficiency",
"virus",
"type",
"1",
"(",
"HIV-1",
")",
"acts",
"in",
"trans",
"to",
"accelerate",
"virus",
"replication",
"and",
"cytopathic",
"effect",
"in",
"T",
"cells",
"."
] | [
0,
9,
10,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
7,
8,
0
] |
17117 | [
"Here",
"it",
"is",
"shown",
"that",
"the",
"HIV-1",
"viral",
"particle",
"contains",
"multiple",
"copies",
"of",
"the",
"vpr",
"protein",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
0
] |
17118 | [
"The",
"vpr",
"product",
"is",
"the",
"first",
"regulatory",
"protein",
"of",
"HIV-1",
"to",
"be",
"found",
"in",
"the",
"virus",
"particle",
"."
] | [
0,
9,
10,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
17119 | [
"This",
"observation",
"raises",
"the",
"possibility",
"that",
"vpr",
"acts",
"to",
"facilitate",
"the",
"early",
"steps",
"of",
"infection",
"before",
"de",
"novo",
"viral",
"protein",
"synthesis",
"occurs",
"."
] | [
0,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
17120 | [
"A",
"novel",
"B-cell",
"lineage-specific",
"transcription",
"factor",
"present",
"at",
"early",
"but",
"not",
"late",
"stages",
"of",
"differentiation",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
17121 | [
"A",
"novel",
"B-cell-specific",
"transcription",
"factor",
",",
"BSAP",
",",
"was",
"identified",
"as",
"a",
"mammalian",
"homolog",
"of",
"the",
"sea",
"urchin",
"protein",
"TSAP",
",",
"which",
"interacts",
"with",
"the",
"promoters",
"of",
"four",
"tissue-specific",
"late",
"histone",
"H2A-2",
"and",
"H2B-2",
"genes",
"."
] | [
0,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
10,
10,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
0,
1,
2,
0
] |
17122 | [
"As",
"shown",
"by",
"mobility-shift",
",",
"methylation",
"interference",
",",
"and",
"mutational",
"analyses",
",",
"the",
"mammalian",
"protein",
"BSAP",
"recognizes",
"all",
"four",
"sea",
"urchin",
"binding",
"sites",
"in",
"a",
"manner",
"indistinguishable",
"from",
"TSAP",
";",
"however",
",",
"the",
"two",
"proteins",
"differ",
"in",
"molecular",
"weight",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
10,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
17123 | [
"BSAP",
"is",
"exclusively",
"restricted",
"to",
"the",
"B-cell",
"lineage",
"of",
"lymphoid",
"differentiation",
"."
] | [
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
17124 | [
"Its",
"expression",
"appears",
"to",
"be",
"activated",
"during",
"pro-B-cell",
"development",
",",
"is",
"abundant",
"at",
"the",
"pre-B-",
"and",
"mature",
"B-cell",
"stages",
",",
"but",
"is",
"absent",
"in",
"terminally",
"differentiated",
"plasma",
"cells",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
7,
8,
0
] |
17125 | [
"Moreover",
",",
"BSAP",
"is",
"clearly",
"a",
"B-cell-specific",
"transcription",
"factor",
",",
"as",
"a",
"wild-type",
"but",
"not",
"a",
"mutant",
"TSAP-binding",
"site",
"of",
"the",
"sea",
"urchin",
"functions",
"only",
"in",
"transfected",
"B",
"cells",
"as",
"an",
"upstream",
"promoter",
"element",
"."
] | [
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
0,
0,
0,
0,
0,
0,
0,
0,
7,
8,
0,
0,
0,
0,
0,
0
] |
17126 | [
"Competition",
"experiments",
"did",
"not",
"reveal",
"any",
"high-affinity",
"binding",
"site",
"for",
"BSAP",
"in",
"known",
"regulatory",
"regions",
"of",
"immunoglobulin",
"and",
"class",
"II",
"major",
"histocompatibility",
"(",
"MHC",
")",
"genes",
",",
"suggesting",
"that",
"BSAP",
"is",
"a",
"regulator",
"of",
"a",
"different",
"set",
"of",
"B-lymphoid-specific",
"genes",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
1,
0,
1,
2,
2,
2,
2,
2,
2,
2,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
17127 | [
"Octamer",
"transcription",
"factors",
"and",
"the",
"cell",
"type-specificity",
"of",
"immunoglobulin",
"gene",
"expression",
"."
] | [
9,
10,
10,
0,
0,
0,
0,
0,
1,
2,
0,
0
] |
17128 | [
"Antibodies",
"are",
"produced",
"exclusively",
"in",
"B",
"lymphocytes",
"."
] | [
0,
0,
0,
0,
0,
7,
8,
0
] |
17129 | [
"The",
"expression",
"of",
"the",
"antibody-encoding",
"genes",
",",
"the",
"immunoglobulin",
"(",
"Ig",
")",
"genes",
",",
"is",
"also",
"restricted",
"to",
"B",
"cells",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
2,
2,
2,
0,
0,
0,
0,
0,
7,
8,
0
] |
17130 | [
"The",
"octamer",
"sequence",
"ATGCAAAT",
"is",
"present",
"in",
"the",
"promoter",
"and",
"the",
"enhancer",
"of",
"Ig",
"genes",
",",
"and",
"plays",
"an",
"important",
"role",
"in",
"its",
"tissue-specific",
"expression",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
17131 | [
"This",
"sequence",
"motif",
"is",
"a",
"binding",
"site",
"for",
"nuclear",
"proteins",
",",
"the",
"so-called",
"octamer",
"transcription",
"factors",
"(",
"Oct",
"or",
"OTF",
"factors",
")",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
10,
0,
9,
0,
9,
10,
0,
0
] |
17132 | [
"The",
"Oct-1",
"protein",
"is",
"present",
"in",
"all",
"cell",
"types",
"analyzed",
"so",
"far",
",",
"whereas",
"Oct-2A",
"and",
"Oct-2B",
"are",
"found",
"mainly",
"in",
"B",
"lymphocytes",
"."
] | [
0,
9,
10,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
9,
0,
0,
0,
0,
7,
8,
0
] |
17133 | [
"All",
"three",
"proteins",
"show",
"the",
"same",
"sequence",
"specificity",
"and",
"binding",
"affinity",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
17134 | [
"It",
"appears",
"that",
"the",
"B",
"cell-specific",
"expression",
"of",
"Ig",
"genes",
"is",
"mediated",
"at",
"least",
"in",
"part",
"by",
"cell",
"type-specific",
"Oct",
"factors",
",",
"and",
"that",
"there",
"are",
"both",
"quantitative",
"and",
"qualitative",
"differences",
"between",
"Oct-1",
"and",
"Oct-2",
"factors",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
0,
0,
0,
0,
0,
0,
0,
9,
10,
10,
10,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
9,
10,
0
] |
17135 | [
"Recently",
",",
"a",
"number",
"of",
"other",
"octamer",
"factor",
"variants",
"were",
"identified",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
17136 | [
"Many",
"of",
"these",
"may",
"be",
"created",
"by",
"alternative",
"splicing",
"of",
"a",
"primary",
"transcript",
"of",
"one",
"Oct",
"factor",
"gene",
"and",
"may",
"serve",
"a",
"specific",
"function",
"in",
"the",
"fine",
"tuning",
"of",
"gene",
"expression",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
17137 | [
"A",
"factor",
"known",
"to",
"bind",
"to",
"endogenous",
"Ig",
"heavy",
"chain",
"enhancer",
"only",
"in",
"lymphocytes",
"is",
"a",
"ubiquitously",
"active",
"transcription",
"factor",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
1,
2,
2,
2,
0,
0,
7,
0,
0,
0,
0,
0,
0,
0
] |
17138 | [
"The",
"transcriptional",
"enhancer",
"located",
"in",
"the",
"first",
"intron",
"of",
"the",
"immunoglobulin",
"heavy",
"chain",
"constant",
"region",
"is",
"a",
"major",
"determinant",
"of",
"B-cell-specific",
"expression",
"of",
"immunoglobulin",
"genes",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
2,
2,
2,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
0
] |
17139 | [
"Like",
"other",
"enhancers",
",",
"the",
"Ig",
"heavy",
"chain",
"enhancer",
"contains",
"several",
"short",
"sequence",
"motifs",
"that",
"bind",
"specific",
"transcription",
"factors",
"."
] | [
0,
0,
0,
0,
0,
1,
2,
2,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
17140 | [
"Each",
"binding",
"site",
"contributes",
"to",
"the",
"overall",
"activity",
"of",
"the",
"enhancer",
",",
"however",
"no",
"single",
"element",
"seems",
"absolutely",
"required",
"for",
"activity",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
17141 | [
"For",
"a",
"better",
"understanding",
"of",
"the",
"Ig",
"heavy",
"chain",
"enhancer",
"components",
",",
"we",
"have",
"cloned",
"and",
"analyzed",
"individual",
"sequence",
"elements",
"."
] | [
0,
0,
0,
0,
0,
0,
1,
2,
2,
2,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
17142 | [
"We",
"find",
"that",
"the",
"factor",
"that",
"binds",
"to",
"the",
"E3",
"enhancer",
"motif",
",",
"CATGTGGC",
",",
"is",
"a",
"ubiquitous",
"transcription",
"factor",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
17143 | [
"It",
"is",
"present",
"in",
"an",
"active",
"form",
"in",
"both",
"B",
"cells",
"and",
"non-B",
"cells",
",",
"where",
"it",
"can",
"mediate",
"transcriptional",
"activation",
"in",
"vitro",
"and",
"in",
"vivo",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
7,
8,
0,
7,
8,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
17144 | [
"However",
",",
"despite",
"its",
"ability",
"to",
"activate",
"transcription",
"of",
"a",
"transfected",
"reporter",
"gene",
",",
"the",
"factor",
"is",
"apparently",
"unable",
"to",
"bind",
"to",
"the",
"endogenous",
"Ig",
"heavy",
"chain",
"enhancer",
"in",
"non-lymphoid",
"cells",
":",
"In",
"previous",
"experiments",
"by",
"others",
",",
"the",
"characteristic",
"in",
"vivo",
"footprint",
"of",
"this",
"factor",
",",
"designated",
"NF-muE3",
",",
"was",
"detected",
"in",
"B",
"cells",
"but",
"not",
"in",
"non-B",
"cells",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
2,
2,
0,
7,
8,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
7,
8,
0,
0,
0,
7,
8,
0
] |
17145 | [
"From",
"this",
"and",
"other",
"findings",
"the",
"picture",
"emerges",
"that",
"there",
"are",
"at",
"least",
"three",
"categories",
"of",
"factors",
"which",
"mediate",
"cell-type-specific",
"transcription",
"in",
"B",
"lymphocytes",
":",
"(",
"a",
")",
"cell-specific",
"factors",
"such",
"as",
"Oct-2A",
"and",
"Oct-2B",
"that",
"are",
"not",
"expressed",
"in",
"most",
"other",
"cell",
"types",
":",
"(",
"b",
")",
"ubiquitous",
"factors",
"such",
"as",
"NF-kappa",
"B",
"that",
"are",
"constitutively",
"active",
"in",
"B",
"cells",
"but",
"are",
"sequestered",
"in",
"an",
"inactive",
"form",
"in",
"other",
"cells",
";",
"(",
"c",
")",
"ubiquitously",
"active",
"factors",
",",
"exemplified",
"by",
"the",
"one",
"binding",
"to",
"the",
"E3",
"sequence",
"motif",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
7,
8,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
0,
0,
0,
0,
0,
7,
8,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
2,
0
] |
17146 | [
"This",
"factor",
"is",
"present",
"in",
"an",
"active",
"form",
"in",
"a",
"variety",
"of",
"cell",
"types",
"but",
"is",
"apparently",
"unable",
"to",
"bind",
"to",
"the",
"endogenous",
"Ig",
"heavy",
"chain",
"enhancer",
"in",
"non-B",
"cells",
",",
"perhaps",
"due",
"to",
"a",
"non-permissive",
"chromatin",
"structure",
"of",
"the",
"Ig",
"heavy",
"chain",
"locus",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
2,
2,
0,
7,
8,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
2,
2,
0
] |
17147 | [
"[",
"Endocrine",
"status",
"changes",
"in",
"children",
"with",
"bronchial",
"asthma",
"]"
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
17148 | [
"A",
"study",
"was",
"made",
"of",
"adrenocortical",
"function",
"by",
"measuring",
"blood",
"plasma",
"cortisol",
"concentration",
"and",
"amount",
"of",
"glucocorticoid",
"receptors",
"in",
"lymphocytes",
"as",
"well",
"as",
"thyroid",
"function",
"by",
"measuring",
"blood",
"plasma",
"triidothyronine",
"and",
"thyroxine",
"concentration",
"in",
"58",
"bronchial",
"asthma",
"children",
"aged",
"1",
"to",
"14",
"years",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
0,
7,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
17149 | [
"The",
"authors",
"revealed",
"alterations",
"in",
"the",
"functional",
"activity",
"of",
"the",
"indicated",
"endocrine",
"glands",
"depending",
"on",
"the",
"intensity",
"of",
"bronchial",
"patency",
"disorders",
"and",
"the",
"nature",
"of",
"the",
"therapeutic",
"measures",
"carried",
"out",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
17150 | [
"TAR",
"independent",
"activation",
"of",
"the",
"human",
"immunodeficiency",
"virus",
"in",
"phorbol",
"ester",
"stimulated",
"T",
"lymphocytes",
"."
] | [
1,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
7,
8,
0
] |
17151 | [
"Multiple",
"regulatory",
"elements",
"in",
"the",
"human",
"immunodeficiency",
"virus",
"long",
"terminal",
"repeat",
"(",
"HIV",
"LTR",
")",
"are",
"required",
"for",
"activation",
"of",
"HIV",
"gene",
"expression",
"."
] | [
0,
0,
0,
0,
0,
1,
2,
2,
2,
2,
2,
0,
1,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
17152 | [
"Previous",
"transfection",
"studies",
"of",
"HIV",
"LTR",
"constructs",
"linked",
"to",
"the",
"chloramphenicol",
"acetyltransferase",
"gene",
"indicated",
"that",
"multiple",
"regulatory",
"regions",
"including",
"the",
"enhancer",
",",
"SP1",
",",
"TATA",
"and",
"TAR",
"regions",
"were",
"important",
"for",
"HIV",
"gene",
"expression",
"."
] | [
0,
0,
0,
0,
1,
2,
2,
0,
0,
0,
1,
2,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
0,
1,
0,
1,
2,
0,
0,
0,
0,
0,
0,
0
] |
17153 | [
"To",
"characterize",
"these",
"regulatory",
"elements",
"further",
",",
"mutations",
"in",
"these",
"regions",
"were",
"inserted",
"into",
"both",
"the",
"5",
"'",
"and",
"3",
"'",
"HIV",
"LTRs",
"and",
"infectious",
"proviral",
"constructs",
"were",
"assembled",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
0,
0,
0,
0,
0,
0,
0
] |
17154 | [
"These",
"constructs",
"were",
"transfected",
"into",
"either",
"HeLa",
"cells",
",",
"Jurkat",
"cells",
"or",
"U937",
"cells",
"in",
"both",
"the",
"presence",
"and",
"absence",
"of",
"phorbol",
"esters",
"which",
"have",
"previously",
"been",
"demonstrated",
"to",
"activate",
"HIV",
"gene",
"expression",
"."
] | [
0,
0,
0,
0,
0,
0,
5,
6,
0,
5,
6,
0,
5,
6,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
17155 | [
"Viral",
"gene",
"expression",
"was",
"assayed",
"by",
"the",
"level",
"of",
"p24",
"gag",
"protein",
"released",
"from",
"cultures",
"transfected",
"with",
"the",
"proviral",
"constructs",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
10,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
17156 | [
"Results",
"in",
"all",
"cell",
"lines",
"indicated",
"that",
"mutations",
"of",
"the",
"SP1",
",",
"TATA",
"and",
"the",
"TAR",
"loop",
"and",
"stem",
"secondary",
"structure",
"resulted",
"in",
"marked",
"decreases",
"in",
"gene",
"expression",
"while",
"mutations",
"of",
"the",
"enhancer",
"motif",
"or",
"TAR",
"primary",
"sequence",
"resulted",
"in",
"only",
"slight",
"decreases",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
0,
1,
0,
0,
1,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
2,
0,
0,
0,
0,
0,
0
] |
17157 | [
"However",
",",
"viruses",
"containing",
"mutations",
"in",
"either",
"the",
"TAR",
"loop",
"sequences",
"or",
"stem",
"secondary",
"structure",
"which",
"were",
"very",
"defective",
"for",
"gene",
"expression",
"in",
"untreated",
"Jurkat",
"cells",
",",
"gave",
"nearly",
"wild-type",
"levels",
"of",
"gene",
"expression",
"in",
"phorbol",
"ester-treated",
"Jurkat",
"cells",
"but",
"not",
"in",
"phorbol",
"ester-treated",
"HeLa",
"or",
"U937",
"cells",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
5,
6,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
5,
6,
0,
0,
0,
0,
0,
5,
0,
5,
6,
0
] |
17158 | [
"High",
"level",
"gene",
"expression",
"of",
"these",
"TAR",
"mutant",
"constructs",
"in",
"phorbol",
"ester-treated",
"Jurkat",
"cells",
"was",
"eliminated",
"by",
"second",
"site",
"mutations",
"in",
"the",
"enhancer",
"region",
"or",
"by",
"disruption",
"of",
"the",
"tat",
"gene",
"."
] | [
0,
0,
0,
0,
0,
0,
1,
2,
2,
0,
0,
0,
5,
6,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
0
] |
17159 | [
"(",
"ABSTRACT",
"TRUNCATED",
"AT",
"250",
"WORDS",
")"
] | [
0,
0,
0,
0,
0,
0,
0
] |
17160 | [
"A",
"case",
"of",
"hypersensitivity",
"to",
"thyroid",
"hormones",
"with",
"normally",
"functioning",
"thyroid",
"gland",
"and",
"increased",
"nuclear",
"triiodothyronine",
"receptors",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
0
] |
17161 | [
"A",
"52-year-old",
"male",
"presented",
"himself",
"with",
"tachycardia",
"crises",
"which",
"appeared",
"first",
"during",
"childhood",
",",
"increased",
"in",
"frequency",
"without",
"goiter",
"or",
"exophthalmos",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
17162 | [
"Cardiac",
"and",
"adrenergic",
"diseases",
"were",
"excluded",
"."
] | [
0,
0,
0,
0,
0,
0,
0
] |
17163 | [
"The",
"thyroid",
"function",
"was",
"normal",
"regarding",
"T4",
",",
"free",
"T4",
"and",
"T3",
",",
"TBG",
",",
"radioiodine",
"uptake",
",",
"TSH",
"and",
"T3",
"suppressibility",
";",
"however",
"the",
"TSH",
"response",
"to",
"TRH",
"was",
"decreased",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
17164 | [
"The",
"lymphocyte",
"nuclear",
"T3",
"receptor",
"was",
"found",
"with",
"an",
"affinity",
"close",
"to",
"that",
"of",
"normal",
"volunteers",
"(",
"Ka",
":",
"1.42",
"x",
"10",
"(",
"10",
")",
"M-1",
"vs",
"1.95",
"+/-",
"0.35",
"x",
"10",
"(",
"10",
")",
"M-1",
")",
"and",
"a",
"binding",
"capacity",
"markedly",
"increased",
"(",
"9.9",
"vs",
"3.7",
"+/-",
"0.4",
"fmol",
"T3/100",
"micrograms",
"DNA",
")",
"."
] | [
0,
9,
10,
10,
10,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
17165 | [
"Pindolol",
"was",
"inefficient",
"on",
"the",
"dysrhythmia",
"which",
"disappeared",
"with",
"carbimazole",
"and",
"relapsed",
"after",
"withdrawal",
"of",
"the",
"antithyroid",
"drug",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
17166 | [
"Under",
"carbimazole",
",",
"the",
"plasma",
"T4",
"markedly",
"decreased",
"(",
"27.7",
"+/-",
"3.6",
"nmol/l",
")",
"but",
"the",
"patient",
"remained",
"euthyroid",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
17167 | [
"The",
"clinical",
"course",
"and",
"the",
"laboratory",
"data",
"suggest",
"that",
"the",
"tachycardia",
"crises",
"are",
"the",
"consequence",
"of",
"a",
"hypersensitivity",
"of",
"the",
"heart",
"to",
"thyroid",
"hormones",
",",
"associated",
"with",
"an",
"increased",
"number",
"of",
"T3",
"nuclear",
"receptor",
"sites",
"in",
"lymphocytes",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
10,
0,
0,
7,
0
] |
17168 | [
"Induction",
"of",
"immediate",
"early",
"response",
"genes",
"by",
"macrophage",
"colony-stimulating",
"factor",
"in",
"normal",
"human",
"monocytes",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
9,
10,
10,
0,
0,
7,
8,
0
] |
17169 | [
"A",
"group",
"of",
"coordinately",
"induced",
"protooncogenes",
",",
"cytoskeletal",
",",
"and",
"extracellular",
"matrix",
"genes",
"have",
"been",
"termed",
"immediate",
"early",
"response",
"genes",
",",
"and",
"their",
"induction",
"has",
"been",
"associated",
"with",
"growth",
"factor",
"-stimulated",
"cell",
"proliferation",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
17170 | [
"We",
"have",
"investigated",
"the",
"induction",
"of",
"these",
"genes",
"by",
"macrophage-CSF",
"(",
"M-CSF",
")",
"in",
"human",
"monocytes",
"that",
"do",
"not",
"proliferate",
"in",
"response",
"to",
"M-CSF",
"but",
"require",
"the",
"factor",
"for",
"optimal",
"cell",
"differentiation",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
9,
0,
0,
7,
8,
0,
0,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
17171 | [
"Normal",
"human",
"monocytes",
"were",
"isolated",
",",
"carefully",
"washed",
",",
"and",
"incubated",
"for",
"36",
"to",
"48",
"h",
"in",
"fetal",
"bovine",
"serum-containing",
"medium",
"."
] | [
0,
7,
8,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
17172 | [
"At",
"the",
"end",
"of",
"this",
"incubation",
"the",
"resting",
"cells",
"were",
"stimulated",
"with",
"M-CSF",
",",
"and",
"RNA",
"was",
"isolated",
"for",
"analysis",
"by",
"Northern",
"blotting",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
17173 | [
"RNA",
"from",
"control",
"resting",
"cells",
"contained",
"low",
"to",
"undetectable",
"levels",
"of",
"c-jun",
",",
"fibronectin",
"receptor",
",",
"and",
"actin",
"mRNA",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
3,
0,
3,
4,
0,
0,
3,
4,
0
] |
17174 | [
"Within",
"15",
"to",
"30",
"min",
"of",
"addition",
"of",
"M-CSF",
",",
"however",
",",
"there",
"was",
"a",
"dramatic",
"coordinate",
"induction",
"of",
"these",
"genes",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
17175 | [
"The",
"c-jun",
"gene",
"expression",
"was",
"very",
"transient",
"and",
"was",
"not",
"detectable",
"by",
"60",
"min",
"after",
"M-CSF",
"addition",
"."
] | [
0,
1,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
0
] |
17176 | [
"In",
"contrast",
",",
"the",
"expression",
"of",
"actin",
"and",
"fibronectin",
"receptor",
"mRNA",
"was",
"more",
"sustained",
",",
"and",
"the",
"expression",
"of",
"these",
"genes",
"remained",
"elevated",
"at",
"24",
"to",
"48",
"h",
"after",
"M-CSF",
"addition",
"."
] | [
0,
0,
0,
0,
0,
0,
3,
0,
3,
4,
4,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
0
] |
17177 | [
"We",
"also",
"observed",
"the",
"induction",
"of",
"the",
"myelomonocytic",
"specific",
"tyrosine",
"kinase",
"hck",
"gene",
"simultaneously",
"with",
"the",
"other",
"immediate",
"early",
"response",
"genes",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
2,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
17178 | [
"The",
"protein",
"synthesis",
"inhibitor",
"cycloheximide",
"did",
"not",
"block",
"the",
"induction",
"of",
"any",
"of",
"these",
"genes",
",",
"and",
"in",
"fact",
",",
"super-induced",
"the",
"expression",
"of",
"c-jun",
"and",
"hck",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
0,
1,
0
] |
17179 | [
"Nuclear",
"run",
"on",
"transcription",
"of",
"the",
"c-jun",
",",
"hck",
",",
"and",
"actin",
"genes",
"."
] | [
0,
0,
0,
0,
0,
0,
1,
0,
1,
0,
0,
1,
2,
0
] |
17180 | [
"Therefore",
",",
"in",
"normal",
"human",
"monocytes",
"M-CSF",
"induces",
"immediate",
"early",
"response",
"genes",
"without",
"inducing",
"cell",
"proliferation",
"."
] | [
0,
0,
0,
0,
9,
10,
10,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
17181 | [
"These",
"genes",
"may",
"then",
"play",
"a",
"role",
"in",
"altering",
"the",
"physiologic",
"status",
"of",
"the",
"cells",
"in",
"response",
"to",
"CSF",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0
] |
17182 | [
"Inducible",
"nuclear",
"factor",
"binding",
"to",
"the",
"kappa",
"B",
"elements",
"of",
"the",
"human",
"immunodeficiency",
"virus",
"enhancer",
"in",
"T",
"cells",
"can",
"be",
"blocked",
"by",
"cyclosporin",
"A",
"in",
"a",
"signal-dependent",
"manner",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
2,
2,
0,
7,
8,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
17183 | [
"Cyclosporin",
"A",
"(",
"CsA",
")",
"is",
"thought",
"to",
"exert",
"its",
"immunosuppressive",
"effects",
"by",
"inhibiting",
"the",
"expression",
"of",
"a",
"distinct",
"set",
"of",
"lymphokine",
"genes",
"which",
"are",
"induced",
"upon",
"T-cell",
"activation",
",",
"among",
"them",
"the",
"gene",
"coding",
"for",
"interleukin-2",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
7,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0
] |
17184 | [
"In",
"addition",
",",
"the",
"activation",
"of",
"the",
"human",
"immunodeficiency",
"virus",
"(",
"HIV",
")",
"is",
"partially",
"suppressed",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
17185 | [
"To",
"better",
"understand",
"the",
"molecular",
"mechanisms",
"underlying",
"suppression",
"by",
"CsA",
",",
"we",
"have",
"investigated",
"the",
"effects",
"of",
"this",
"drug",
"on",
"transcription",
"factors",
"in",
"T",
"cells",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
7,
8,
0
] |
17186 | [
"Here",
"we",
"report",
"that",
"the",
"formation",
"of",
"two",
"distinct",
"mitogen-inducible",
"DNA-binding",
"complexes",
",",
"the",
"kappa",
"B",
"complex",
"within",
"the",
"HIV",
"enhancer",
"and",
"the",
"NFAT-1",
"complex",
"within",
"the",
"interleukin-2",
"enhancer",
",",
"is",
"inhibited",
"in",
"the",
"presence",
"of",
"CsA",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
0,
0,
9,
10,
0,
0,
1,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
17187 | [
"The",
"kappa",
"B-binding",
"activity",
"with",
"the",
"HIV",
"enhancer",
"is",
"inhibited",
"only",
"if",
"it",
"is",
"activated",
"via",
"the",
"mitogen",
"phytohemagglutinin",
"whereas",
"phorbol",
"myristate",
"acetate-mediated",
"activation",
"is",
"completely",
"insensitive",
"to",
"the",
"drug",
"."
] | [
0,
0,
0,
0,
0,
0,
1,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
17188 | [
"This",
"suggests",
"a",
"model",
"in",
"which",
"functionally",
"indistinguishable",
"kappa",
"B",
"complexes",
"can",
"be",
"activated",
"via",
"two",
"separate",
"pathways",
"of",
"signal",
"transduction",
"distinguishable",
"by",
"CsA",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
17189 | [
"Purification",
"of",
"TCF-1",
"alpha",
",",
"a",
"T-cell-specific",
"transcription",
"factor",
"that",
"activates",
"the",
"T-cell",
"receptor",
"C",
"alpha",
"gene",
"enhancer",
"in",
"a",
"context-dependent",
"manner",
"."
] | [
0,
0,
9,
10,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
2,
2,
2,
2,
0,
0,
0,
0,
0
] |
17190 | [
"The",
"differentiation",
"of",
"T",
"cells",
"into",
"functionally",
"diverse",
"subpopulations",
"is",
"controlled",
"in",
"part",
",",
"by",
"transcriptional",
"activation",
"and",
"silencing",
";",
"however",
",",
"little",
"is",
"known",
"in",
"detail",
"about",
"the",
"proteins",
"that",
"influence",
"this",
"developmental",
"process",
"."
] | [
0,
0,
0,
7,
8,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
17191 | [
"We",
"have",
"purified",
"a",
"new",
"T-cell-specific",
"factor",
",",
"TCF-1",
"alpha",
",",
"that",
"is",
"implicated",
"in",
"the",
"activation",
"of",
"genes",
"encoding",
"a",
"major",
"component",
"of",
"the",
"human",
"T-cell",
"receptor",
"(",
"TCR",
")",
"."
] | [
0,
0,
0,
0,
0,
7,
0,
0,
9,
10,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
10,
0,
9,
0,
0
] |
17192 | [
"TCF-1",
"alpha",
",",
"originally",
"identified",
"and",
"purified",
"through",
"its",
"binding",
"sites",
"on",
"the",
"HIV-1",
"promoter",
",",
"was",
"found",
"to",
"bind",
"to",
"the",
"TCR",
"alpha",
"enhancer",
"and",
"to",
"promoters",
"for",
"several",
"genes",
"expressed",
"at",
"significantly",
"earlier",
"stages",
"of",
"T-cell",
"development",
"than",
"the",
"TCR",
"alpha",
"gene",
"(",
"e.g.",
",",
"p56lck",
"and",
"CD3",
"delta",
")",
"."
] | [
9,
10,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
0,
0,
0,
0,
0,
0,
0,
1,
2,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
7,
0,
0,
0,
1,
2,
2,
0,
0,
0,
1,
0,
1,
2,
0,
0
] |
17193 | [
"Sequences",
"related",
"to",
"the",
"TCF-1",
"alpha",
"binding",
"motif",
"(",
"5'-GGCACCCTTTGA-3",
"'",
")",
"are",
"also",
"found",
"in",
"the",
"human",
"TCR",
"delta",
"(",
"and",
"possibly",
"TCR",
"beta",
")",
"enhancers",
"."
] | [
0,
0,
0,
0,
1,
2,
2,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
2,
0,
0,
0,
1,
2,
0,
0,
0
] |
17194 | [
"Southwestern",
"and",
"gel",
"renaturation",
"experiments",
"with",
"the",
"use",
"of",
"purified",
"protein",
"fractions",
"revealed",
"that",
"TCF-1",
"alpha",
"activity",
"is",
"derived",
"from",
"a",
"family",
"of",
"57-",
"to",
"53-kD",
"proteins",
"that",
"are",
"abundantly",
"expressed",
"in",
"mature",
"and",
"immature",
"T-cell",
"lines",
"(",
"Jurkat",
",",
"CCRF-CEM",
")",
"and",
"not",
"in",
"mature",
"B",
"cells",
"(",
"JY",
",",
"Namalwa",
")",
"or",
"nonlymphoid",
"(",
"HeLa",
")",
"cell",
"lines",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
5,
6,
0,
5,
0,
5,
0,
0,
0,
0,
0,
7,
8,
0,
5,
0,
5,
0,
0,
0,
0,
5,
0,
0,
0,
0
] |
17195 | [
"A",
"small",
"95-bp",
"fragment",
"of",
"the",
"TCR",
"alpha",
"control",
"region",
"that",
"contains",
"the",
"TCF-1",
"alpha",
"binding",
"site",
"juxtaposed",
"between",
"a",
"cAMP-response",
"element",
"(",
"the",
"CRE",
"or",
"T",
"alpha",
"1",
"motif",
")",
"and",
"the",
"binding",
"site",
"for",
"a",
"distinct",
"lymphoid-specific",
"protein",
"(",
"TCF-2",
"alpha",
")",
"behaved",
"as",
"a",
"potent",
"T-cell-specific",
"enhancer",
"in",
"vivo",
"."
] | [
0,
0,
0,
0,
0,
0,
1,
2,
2,
2,
0,
0,
0,
1,
2,
2,
2,
0,
0,
0,
1,
2,
0,
0,
1,
0,
1,
2,
2,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
0,
0,
0,
0,
0,
1,
2,
0,
0,
0
] |
17196 | [
"Tandem",
"copies",
"of",
"this",
"enhancer",
"functioned",
"synergistically",
"in",
"mature",
"(",
"Jurkat",
")",
"T-cell",
"lines",
"as",
"well",
"as",
"resting",
"and",
"activated",
"immature",
"(",
"CCRF-CEM",
")",
"T-cell",
"lines",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
5,
0,
5,
6,
0,
0,
0,
0,
0,
0,
0,
0,
5,
0,
5,
6,
0
] |
17197 | [
"Mutation",
"of",
"the",
"TCF-1",
"alpha",
"binding",
"site",
"diminished",
"enhancer",
"activity",
"and",
"disrupted",
"the",
"synergism",
"observed",
"in",
"vivo",
"between",
"tandem",
"enhancer",
"repeats",
"."
] | [
0,
0,
0,
1,
2,
2,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
17198 | [
"The",
"TCF-1",
"alpha",
"binding",
"site",
"was",
"also",
"required",
"for",
"TCR",
"alpha",
"enhancer",
"activity",
"in",
"transcriptionally",
"active",
"extracts",
"from",
"Jurkat",
"but",
"not",
"HeLa",
"cells",
",",
"confirming",
"that",
"TCF-1",
"alpha",
"is",
"a",
"T-cell-specific",
"transcription",
"factor",
"."
] | [
0,
1,
2,
2,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
5,
0,
0,
5,
6,
0,
0,
0,
9,
10,
0,
0,
7,
0,
0,
0
] |
17199 | [
"Curiously",
",",
"the",
"TCF-1",
"alpha",
"binding",
"element",
"was",
"inactive",
"in",
"vivo",
"when",
"removed",
"from",
"its",
"neighboring",
"elements",
"on",
"the",
"TCR",
"alpha",
"enhancer",
"and",
"positioned",
"in",
"one",
"or",
"more",
"copies",
"upstream",
"of",
"a",
"heterologous",
"promoter",
"."
] | [
0,
0,
0,
9,
10,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
17200 | [
"Thus",
",",
"the",
"transcriptional",
"activity",
"of",
"TCF-1",
"alpha",
"appears",
"to",
"depend",
"on",
"the",
"TCF-2",
"alpha",
"and",
"T",
"alpha",
"1",
"(",
"CREB",
")",
"transcription",
"factors",
"and",
"the",
"context",
"of",
"its",
"binding",
"site",
"within",
"the",
"TCR",
"alpha",
"enhancer",
"."
] | [
0,
0,
0,
0,
0,
0,
9,
10,
0,
0,
0,
0,
0,
9,
10,
0,
9,
10,
10,
10,
10,
10,
10,
10,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
2,
0
] |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.