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16901
[ "Type-II", "estrogen", "binding", "sites", "in", "a", "lymphoblastoid", "cell", "line", "and", "growth-inhibitory", "effect", "of", "estrogen", ",", "anti-estrogen", "and", "bioflavonoids", "." ]
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16902
[ "Type-II", "estrogen-binding", "sites", "(", "type-II", "EBS", ")", "have", "been", "demonstrated", "in", "the", "human", "lymphoblastoid", "cell", "line", "IM-9", "using", "a", "whole-cell", "assay", "with", "(", "6", ",", "7-3H", ")", "estradiol", "(", "3H-E2", ")", "as", "tracer", "." ]
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16903
[ "Competition", "analysis", "showed", "that", "the", "anti-estrogen", "tamoxifen", "and", "the", "flavonoids", "quercetin", "and", "rutin", "competed", "for", "(", "3H", ")", "-E2", "binding", "to", "type-II", "EBS", "." ]
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16904
[ "Growth", "experiments", "demonstrated", "that", "diethylstilbestrol", "(", "DES", ")", "tamoxifen", "(", "TAM", ")", ",", "quercetin", "and", "rutin", "exerted", "a", "reversible", "dose-dependent", "inhibition", "of", "cell", "proliferation", "in", "the", "range", "of", "concentrations", "between", "10", "nM", "and", "10", "microM", "." ]
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16905
[ "The", "relative", "binding", "affinity", "of", "quercetin", ",", "rutin", ",", "DES", "and", "TAM", "for", "type-II", "EBS", "correlated", "well", "with", "their", "potency", "as", "cell", "growth", "inhibitors", "." ]
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16906
[ "Moreover", ",", "hesperidin", ",", "a", "flavonoid", "which", "does", "not", "bind", "to", "type-II", "EBS", ",", "was", "ineffective", "in", "inhibiting", "cell", "growth", "." ]
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16907
[ "Cell-cycle", "analysis", "showed", "that", "the", "growth-inhibitory", "effect", "of", "DES", ",", "TAM", "or", "quercetin", "was", "due", "to", "a", "blocking", "effect", "in", "the", "G0-G1", "phases", "." ]
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16908
[ "Our", "results", "suggest", "that", "high", "estrogen", "and", "anti-estrogen", "concentrations", "and", "flavonoids", "may", "regulate", "IM-9", "cell", "growth", "through", "a", "common", "mechanism", "involving", "a", "binding", "interaction", "with", "type-II", "EBS", "." ]
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16909
[ "[", "Glucocorticoid", "receptors", "in", "peripheral", "blood", "lymphocytes", "of", "patients", "with", "bronchial", "asthma", "]" ]
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16910
[ "Quantitation", "of", "glucocorticoid", "receptors", "(", "GCR", ")", "and", "the", "study", "of", "their", "affinity", "for", "glucocorticosteroids", "(", "GCS", ")", "were", "made", "in", "peripheral", "blood", "lymphocytes", "of", "bronchial", "asthma", "(", "BA", ")", "patients", "in", "consideration", "of", "GCR", "treatment", "and", "serum", "levels", "of", "endogenous", "cortisol", "." ]
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16911
[ "It", "is", "stated", "that", "GCR", "of", "healthy", "controls", "and", "GCS-untreated", "patients", "outnumbered", "those", "of", "cortisol-dependent", "BA", "patients", "on", "hormone", "therapy", "." ]
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16912
[ "Following", "discontinuation", "of", "glucocorticoid", "drugs", "GCR", "count", "in", "cortisol-dependent", "BA", "tends", "to", "rise", "." ]
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16913
[ "Endogenous", "cortisol", "has", "no", "effect", "on", "GCR", "level", "estimated", "by", "3H-triamcinolone", "acetonide", "." ]
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16914
[ "Two", "glucocorticoid", "binding", "sites", "on", "the", "human", "glucocorticoid", "receptor", "." ]
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16915
[ "Glucocorticoids", "are", "known", "to", "have", "a", "lytic", "effect", "in", "leukemic", "cells", "via", "interactions", "with", "the", "glucocorticoid", "receptor", "(", "GR", ")", "." ]
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16916
[ "Cortisol", "and", "various", "synthetic", "glucocorticoids", "bind", "to", "the", "GR", "with", "one-site", "kinetics", "." ]
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16917
[ "Cortivazol", "(", "CVZ", ")", "is", "a", "unique", ",", "high", "potency", "synthetic", "glucocorticoid", ",", "which", "has", "a", "phenylpyrazol", "fused", "to", "the", "A-ring", "of", "the", "steroid", "nucleus", "and", "displays", "binding", "consistent", "with", "two", "or", "more", "sites", "in", "the", "cytosol", "from", "CEM", "C7", "cells", "(", "a", "human", "acute", "lymphoblastic", "T-cell", "line", ")", "." ]
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16918
[ "It", "has", "previously", "been", "shown", "that", "the", "lower", "affinity", "class", "of", "sites", "are", "similar", "in", "affinity", "and", "site", "molarity", "to", "those", "recognized", "by", "dexamethasone", "." ]
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16919
[ "The", "higher", "affinity", "sites", "bind", "CVZ", "with", "20-", "to", "50-fold", "greater", "affinity", ",", "consistent", "with", "CVZ", "'s", "enhanced", "biological", "effects", "." ]
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16920
[ "In", "mutant", "leukemic", "cells", "resistant", "to", "the", "lytic", "effects", "of", "dexamethasone", ",", "CVZ", "both", "lyses", "the", "cells", "and", "recognizes", "a", "single", "class", "of", "sites", "similar", "to", "the", "high", "affinity", "site", "in", "CEM", "C7", "cells", "." ]
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16921
[ "We", "have", "carried", "out", "experiments", "to", "define", "the", "nature", "of", "the", "higher", "affinity", "CVZ", "binding", "site", "." ]
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16922
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16923
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16924
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16925
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16926
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16927
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16928
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16929
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16930
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16931
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16932
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16933
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16934
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16935
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16936
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16937
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16938
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16939
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16940
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16941
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16942
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16943
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16944
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16945
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16946
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16947
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16948
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16949
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