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17601
[ "One", "(", "site", "B", ")", "contained", "a", "palindromic", "sequence", "with", "homology", "to", "steroid/thyroid", "hormone", "response", "elements", "but", "was", "distinct", "from", "previously", "described", "binding", "sites", "of", "this", "class", "." ]
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17602
[ "A", "novel", "T-cell", "protein", "recognized", "the", "palindromic", "sequence", "within", "site", "B", "and", "also", "bound", "estrogen-", "or", "thyroid", "hormone-response", "elements", "with", "lower", "affinity", "." ]
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17603
[ "A", "7-base-pair", "mutation", "in", "the", "site", "B", "palindrome", ",", "which", "destroyed", "protein", "binding", ",", "resulted", "in", "increased", "expression", "from", "the", "human", "immunodeficiency", "virus", "type", "1", "long", "terminal", "repeat", "in", "T", "cells", "." ]
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17604
[ "Progesterone", "suppression", "of", "pregnancy", "lymphocytes", "is", "not", "mediated", "by", "glucocorticoid", "effect", "." ]
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17605
[ "This", "study", "investigated", "whether", "the", "suppressive", "effect", "of", "progesterone", "on", "pregnancy", "lymphocytes", "is", "mediated", "by", "specific", "progesterone", "receptors", "." ]
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17606
[ "The", "effects", "of", "a", "competitive", "progesterone", "antagonist", "(", "RU486", ")", "and", "a", "specific", "glucocorticoid", "receptor", "blocker", "(", "RU43044", ")", "were", "tested", "on", "the", "release", "of", "a", "blocking", "factor", "by", "progesterone-treated", "pregnancy", "lymphocytes", "." ]
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17607
[ "RU", "486", "tested", "at", "an", "equal", "concentration", "as", "progesterone", "significantly", "inhibited", "the", "production", "of", "the", "blocking", "factor", ",", "while", "RU", "43044", "was", "without", "effect", "." ]
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17608
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17609
[ "The", "56-59-kilodalton", "protein", "identified", "in", "untransformed", "steroid", "receptor", "complexes", "is", "a", "unique", "protein", "that", "exists", "in", "cytosol", "in", "a", "complex", "with", "both", "the", "70-", "and", "90-kilodalton", "heat", "shock", "proteins", "." ]
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17610
[ "It", "has", "previously", "been", "shown", "that", "9S", ",", "untransformed", "progestin", ",", "estrogen", ",", "androgen", ",", "and", "glucocorticoid", "receptor", "complexes", "in", "rabbit", "uterine", "and", "liver", "cytosols", "contain", "a", "59-kDa", "protein", "[", "Tai", ",", "P.K.", ",", "Maeda", ",", "Y.", ",", "Nakao", ",", "K.", ",", "Wakim", ",", "N.G.", ",", "Duhring", ",", "J.L.", ",", "&", "Faber", ",", "L.E.", "(", "1986", ")", "Biochemistry", "25", ",", "5269-5275", "]", "." ]
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17611
[ "In", "this", "work", "we", "show", "that", "the", "monoclonal", "antibody", "KN", "382/EC1", "raised", "against", "the", "rabbit", "59-kDa", "protein", "reacts", "with", "9S", ",", "untransformed", "glucocorticoid", "receptor", "complexes", "in", "cytosol", "prepared", "from", "human", "IM-9", "lymphocytes", "but", "not", "with", "4S", "salt-transformed", "receptors", "." ]
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17612
[ "The", "human", "protein", "recognized", "by", "the", "EC1", "antibody", "is", "a", "56-kDa", "protein", "(", "p56", ")", "of", "moderate", "abundance", "located", "predominantly", "in", "the", "cytoplasm", "by", "indirect", "immunofluorescence", "." ]
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17613
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17614
[ "N-Terminal", "sequencing", "(", "20", "amino", "acids", ")", "shows", "that", "p56", "is", "a", "unique", "human", "protein", "." ]
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17615
[ "When", "p56", "is", "immunoadsorbed", "from", "IM-9", "cell", "cytosol", ",", "both", "the", "70-", "and", "90-kDa", "heat", "shock", "proteins", "are", "coadsorbed", "in", "an", "immune-specific", "manner", "." ]
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17616
[ "Neither", "heat", "shock", "protein", "reacts", "directly", "with", "the", "EC1", "antibody", "." ]
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17617
[ "We", "conclude", "that", "p56", "exists", "in", "cytosol", "in", "a", "higher", "order", "complex", "containing", "hsp70", "and", "hsp90", ",", "both", "of", "which", "in", "turn", "have", "been", "found", "to", "be", "associated", "with", "untransformed", "steroid", "receptors", "." ]
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17618
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17619
[ "The", "ets", "proto-oncogene", "family", "is", "a", "group", "of", "sequence-related", "genes", "whose", "normal", "cellular", "function", "is", "unknown", "." ]
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17620
[ "In", "a", "study", "of", "cellular", "proteins", "involved", "in", "the", "transcriptional", "regulation", "of", "murine", "retroviruses", "in", "T", "lymphocytes", ",", "we", "have", "discovered", "that", "a", "member", "of", "the", "ets", "gene", "family", "encodes", "a", "sequence-specific", "DNA-binding", "protein", "." ]
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17621
[ "A", "mouse", "ets-1", "cDNA", "clone", "was", "obtained", "by", "screening", "a", "mouse", "thymus", "cDNA", "expression", "library", "with", "a", "double-stranded", "oligonucleotide", "probe", "representing", "20", "bp", "of", "the", "Moloney", "murine", "sarcoma", "virus", "(", "MSV", ")", "long", "terminal", "repeat", "(", "LTR", ")", "." ]
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17622
[ "The", "cDNA", "sequence", "has", "an", "813-bp", "open", "reading", "frame", "(", "ORF", ")", "whose", "predicted", "amino", "acid", "sequence", "is", "97.6", "%", "identical", "to", "the", "272", "carboxy-terminal", "amino", "acids", "of", "the", "human", "ets-1", "protein", "." ]
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17623
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17624
[ "A", "mutant", "LTR", "containing", "four", "base", "pair", "substitutions", "in", "the", "ets-1", "binding", "site", "was", "constructed", "and", "was", "shown", "to", "have", "reduced", "binding", "in", "vitro", "." ]
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17625
[ "Transcriptional", "efficiency", "of", "the", "MSV", "LTR", "promoter", "containing", "this", "disrupted", "ets-1", "binding", "site", "was", "compared", "to", "the", "activity", "of", "a", "wild-type", "promoter", "in", "mouse", "T", "lymphocytes", "in", "culture", ",", "and", "15-", "to", "20-fold", "reduction", "in", "expression", "of", "a", "reporter", "gene", "was", "observed", "." ]
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17626
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17627
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17628
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17629
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17630
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17631
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17632
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17633
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17634
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17635
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17636
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17637
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17638
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17639
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17640
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17641
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17642
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17643
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17644
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17645
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17647
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17648
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17649
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17650
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17652
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17681
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17690
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