id
stringlengths 1
5
| tokens
sequence | ner_tags
sequence |
---|---|---|
16001 | [
"The",
"detection",
"of",
"both",
"M-CSF",
"and",
"c-fms",
"expression",
"by",
"cells",
"of",
"the",
"monocyte",
"lineage",
"has",
"suggested",
"that",
"M-CSF",
"may",
"act",
"by",
"an",
"autocrine",
"mechanism",
"."
] | [
0,
0,
0,
0,
9,
0,
9,
0,
0,
0,
0,
0,
7,
8,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0
] |
16002 | [
"Interestingly",
",",
"it",
"has",
"been",
"shown",
"that",
"M-CSF",
"can",
"induce",
"the",
"expression",
"of",
"its",
"own",
"gene",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
16003 | [
"Although",
"sensitivity",
"to",
"M-CSF",
"can",
"be",
"modulated",
"by",
"regulation",
"of",
"receptor",
"expression",
"and",
"function",
",",
"M-CSF",
"responsiveness",
"is",
"largely",
"determined",
"at",
"a",
"postreceptor",
"level",
"."
] | [
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
16004 | [
"To",
"date",
",",
"little",
"is",
"known",
"about",
"the",
"intracellular",
"pathway",
"of",
"M-CSF",
"signal",
"transduction",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
0,
0
] |
16005 | [
"We",
"have",
"therefore",
"investigated",
"the",
"changes",
"in",
"protein",
"kinase",
"C",
"(",
"PKC",
")",
"activity",
"upon",
"exposure",
"of",
"monocytes",
"to",
"M-CSF",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
9,
10,
10,
0,
9,
0,
0,
0,
0,
0,
7,
0,
9,
0
] |
16006 | [
"We",
"show",
"that",
"M-CSF",
"activates",
"and",
"translocates",
"PKC",
"."
] | [
0,
0,
0,
9,
0,
0,
0,
9,
0
] |
16007 | [
"Inhibition",
"of",
"PKC",
"by",
"the",
"isoquinoline",
"derivative",
"H7",
"abolishes",
"induction",
"of",
"M-CSF",
"by",
"M-CSF",
"."
] | [
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
9,
0
] |
16008 | [
"Furthermore",
",",
"activation",
"of",
"PKC",
"was",
"pertussis-toxin-sensitive",
"and",
"was",
"associated",
"with",
"the",
"detection",
"of",
"an",
"NF",
"kappa",
"B",
"protein",
"in",
"nuclear",
"extracts",
"of",
"M-CSF-induced",
"blood",
"monocytes",
"but",
"not",
"in",
"monocytes",
"exposed",
"to",
"medium",
"treatment",
"only",
"."
] | [
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
10,
10,
0,
0,
0,
0,
0,
7,
8,
0,
0,
0,
7,
0,
0,
0,
0,
0,
0
] |
16009 | [
"The",
"results",
"suggest",
"that",
"M-CSF",
"induction",
"of",
"M-CSF",
"involves",
"G",
"proteins",
",",
"PKC",
"and",
"NF",
"kappa",
"B",
"."
] | [
0,
0,
0,
0,
9,
0,
0,
9,
0,
9,
10,
0,
9,
0,
9,
10,
10,
0
] |
16010 | [
"Clone",
"pAT",
"133",
"identifies",
"a",
"gene",
"that",
"encodes",
"another",
"human",
"member",
"of",
"a",
"class",
"of",
"growth",
"factor-induced",
"genes",
"with",
"almost",
"identical",
"zinc-finger",
"domains",
"."
] | [
0,
1,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
16011 | [
"We",
"report",
"the",
"structure",
"and",
"regulation",
"of",
"a",
"gene",
"represented",
"by",
"clone",
"pAT",
"133",
",",
"which",
"is",
"induced",
"upon",
"transition",
"from",
"a",
"resting",
"state",
"(",
"G0",
")",
"through",
"the",
"early",
"phase",
"of",
"the",
"cell",
"cycle",
"(",
"G1",
")",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
16012 | [
"The",
"pAT",
"133",
"gene",
"is",
"immediately",
"induced",
",",
"with",
"FOS",
"-like",
"kinetics",
",",
"in",
"human",
"T",
"cells",
"and",
"in",
"fibroblasts",
"."
] | [
0,
1,
2,
2,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
7,
8,
8,
0,
0,
7,
0
] |
16013 | [
"Primary",
"structure",
"analysis",
"showed",
"that",
"the",
"encoded",
"protein",
"contains",
"three",
"tandem",
"zinc-finger",
"sequences",
"of",
"the",
"type",
"Cys2-Xaa12-His2",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
16014 | [
"This",
"zinc-finger",
"region",
",",
"which",
"is",
"thought",
"to",
"bind",
"DNA",
"in",
"a",
"sequence-specific",
"manner",
",",
"is",
"similar",
"(",
"greater",
"than",
"80",
"%",
"on",
"the",
"amino",
"acid",
"level",
")",
"to",
"two",
"previously",
"described",
"transcription",
"factors",
"pAT",
"225/EGR1",
"and",
"pAT",
"591/EGR2",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
10,
10,
0,
9,
10,
0
] |
16015 | [
"Except",
"for",
"the",
"conserved",
"zinc-finger",
"domains",
",",
"the",
"amino",
"acid",
"sequences",
"of",
"the",
"three",
"proteins",
"are",
"distinct",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
16016 | [
"This",
"structural",
"similarity",
"suggests",
"that",
"the",
"pAT",
"133",
"gene",
"encodes",
"a",
"transcription",
"factor",
"with",
"a",
"specific",
"biological",
"function",
"."
] | [
0,
0,
0,
0,
0,
0,
1,
2,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
16017 | [
"Comparing",
"the",
"regulation",
"of",
"these",
"related",
"zinc-finger-encoding",
"genes",
"showed",
"coordinate",
"induction",
"upon",
"mitogenic",
"stimulation",
"of",
"resting",
"T",
"lymphocytes",
"and",
"of",
"resting",
"fibroblasts",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
7,
8,
0,
0,
0,
7,
0
] |
16018 | [
"However",
",",
"upon",
"transition",
"from",
"a",
"proliferating",
"(",
"G1",
")",
"to",
"a",
"resting",
"state",
"of",
"the",
"cell",
"cycle",
"the",
"three",
"genes",
"were",
"differently",
"regulated",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
16019 | [
"In",
"human",
"histiocytic",
"U937",
"cells",
"mRNA",
"of",
"clone",
"pAT",
"133",
"was",
"constitutively",
"expressed",
",",
"whereas",
"mRNA",
"of",
"pAT",
"225/EGR1",
"was",
"induced",
"upon",
"induction",
"of",
"terminal",
"differentiation",
"."
] | [
0,
5,
6,
6,
6,
0,
0,
0,
3,
4,
0,
0,
0,
0,
0,
0,
0,
3,
4,
0,
0,
0,
0,
0,
0,
0,
0
] |
16020 | [
"In",
"contrast",
"mRNA",
"representing",
"pAT",
"591/EGR2",
"was",
"not",
"expressed",
"in",
"these",
"cells",
"."
] | [
0,
0,
0,
0,
9,
10,
0,
0,
0,
0,
0,
0,
0
] |
16021 | [
"This",
"difference",
"in",
"gene",
"regulation",
"suggests",
"distinct",
"biological",
"roles",
"in",
"the",
"control",
"of",
"cell",
"proliferation",
"for",
"the",
"respective",
"proteins",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
16022 | [
"v-erbA",
"overexpression",
"is",
"required",
"to",
"extinguish",
"c-erbA",
"function",
"in",
"erythroid",
"cell",
"differentiation",
"and",
"regulation",
"of",
"the",
"erbA",
"target",
"gene",
"CAII",
"."
] | [
9,
0,
0,
0,
0,
0,
9,
0,
0,
7,
8,
0,
0,
0,
0,
0,
1,
2,
2,
2,
0
] |
16023 | [
"The",
"v-erbA",
"oncoprotein",
"represents",
"a",
"retrovirus-transduced",
"oncogenic",
"version",
"of",
"the",
"thyroid",
"hormone",
"(",
"T3/T4",
")",
"receptor",
"c-erbA",
"(",
"type",
"alpha",
")",
"."
] | [
0,
9,
10,
0,
0,
0,
0,
0,
0,
0,
9,
10,
10,
10,
10,
10,
10,
0,
0,
0,
0,
0
] |
16024 | [
"It",
"contributes",
"to",
"virus-induced",
"erythroleukemia",
"by",
"efficiently",
"arresting",
"differentiation",
"of",
"red",
"cell",
"progenitors",
"and",
"by",
"suppressing",
"transcription",
"of",
"erythrocyte-specific",
"genes",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
7,
8,
8,
0,
0,
0,
0,
0,
0,
0,
0
] |
16025 | [
"Here",
",",
"we",
"show",
"that",
"v-erbA",
"and",
"c-erbA",
"bind",
"directly",
"to",
"sequences",
"within",
"the",
"promoter",
"of",
"the",
"erythrocyte-specific",
"carbonic",
"anhydrase",
"II",
"(",
"CAII",
")",
",",
"a",
"gene",
"whose",
"transcription",
"is",
"efficiently",
"suppressed",
"by",
"v-erbA",
"."
] | [
0,
0,
0,
0,
0,
9,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
10,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0
] |
16026 | [
"This",
"erbA-binding",
"site",
"confers",
"thyroid",
"hormone",
"responsiveness",
"to",
"a",
"heterologous",
"promoter",
"in",
"transient",
"expression",
"experiments",
"and",
"is",
"a",
"target",
"for",
"efficient",
"down-regulation",
"of",
"CAII",
"transcription",
"by",
"the",
"v-erbA",
"oncoprotein",
"."
] | [
0,
1,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
0,
0,
0,
9,
10,
0
] |
16027 | [
"In",
"stably",
"transformed",
"erythroblasts",
"coexpressing",
"the",
"v-erbA",
"oncoprotein",
"and",
"the",
"c-erbA/T3",
"receptor",
"at",
"an",
"approximately",
"equimolar",
"ratio",
",",
"c-erbA",
"activity",
"is",
"dominant",
"over",
"v-erbA",
"."
] | [
0,
0,
0,
7,
0,
0,
9,
10,
0,
0,
9,
10,
0,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
9,
0
] |
16028 | [
"T3",
"efficiently",
"induced",
"erythroid",
"differentiation",
"in",
"these",
"cells",
",",
"thus",
"overcoming",
"the",
"v-erbA",
"-mediated",
"differentiation",
"arrest",
"."
] | [
0,
0,
0,
7,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0
] |
16029 | [
"Likewise",
",",
"T3",
"activated",
"CAII",
"transcription",
"as",
"well",
"as",
"transient",
"expression",
"of",
"a",
"T3-responsive",
"reporter",
"gene",
"containing",
"the",
"CAII-specific",
"erbA-binding",
"site",
"."
] | [
0,
0,
0,
0,
1,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
0
] |
16030 | [
"The",
"c-erbA",
"-dependent",
"activation",
"of",
"this",
"CAII",
"reporter",
"construct",
"could",
"only",
"be",
"suppressed",
"by",
"very",
"high",
"amounts",
"of",
"v-erbA",
"."
] | [
0,
9,
0,
0,
0,
0,
1,
2,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0
] |
16031 | [
"Our",
"results",
"suggest",
"that",
"overexpression",
"of",
"v-erbA",
"is",
"required",
"for",
"its",
"function",
"as",
"an",
"oncoprotein",
"."
] | [
0,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
16032 | [
"Anti-CD2",
"receptor",
"antibodies",
"activate",
"the",
"HIV",
"long",
"terminal",
"repeat",
"in",
"T",
"lymphocytes",
"."
] | [
9,
10,
10,
0,
0,
1,
2,
2,
2,
0,
7,
8,
0
] |
16033 | [
"The",
"CD2",
"T",
"lymphocyte",
"glycoprotein",
"surface",
"molecule",
"mediates",
"both",
"cell",
"to",
"cell",
"adhesion",
"and",
"T",
"cell",
"activation",
",",
"two",
"processes",
"that",
"are",
"involved",
"in",
"the",
"spread",
"of",
"HIV",
"infection",
"."
] | [
0,
9,
7,
8,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
7,
8,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
16034 | [
"Treatment",
"of",
"chronically",
"HIV-infected",
"PBMC",
"with",
"anti-CD2",
"mAb",
"has",
"been",
"shown",
"to",
"induce",
"the",
"expression",
"of",
"infectious",
"virus",
"from",
"these",
"cultures",
"."
] | [
0,
0,
0,
0,
7,
0,
9,
10,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
16035 | [
"In",
"this",
"study",
"we",
"investigated",
"the",
"mechanisms",
"whereby",
"anti-CD2",
"antibodies",
"stimulate",
"viral",
"production",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
0,
0,
0,
0
] |
16036 | [
"We",
"demonstrate",
"that",
"treatment",
"of",
"transiently",
"transfected",
"T",
"lymphocytes",
"with",
"anti-CD2",
"antibodies",
"results",
"in",
"activation",
"of",
"the",
"HIV",
"long",
"terminal",
"repeat",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
7,
8,
0,
9,
10,
0,
0,
0,
0,
0,
1,
2,
2,
2,
0
] |
16037 | [
"Furthermore",
",",
"CAT",
"assays",
"using",
"mutated",
"HIV",
"long",
"terminal",
"repeat-CAT",
"constructs",
"and",
"gel",
"shift",
"assays",
"demonstrate",
"that",
"this",
"activation",
"is",
"dependent",
"on",
"the",
"NF-kappa",
"B",
"enhancer",
"."
] | [
0,
0,
9,
0,
0,
0,
1,
2,
2,
2,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
2,
0
] |
16038 | [
"These",
"studies",
"suggest",
"that",
"interaction",
"of",
"CD2",
"with",
"its",
"natural",
"ligand",
",",
"LFA-3",
",",
"may",
"play",
"a",
"role",
"in",
"regulation",
"of",
"HIV",
"expression",
"."
] | [
0,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
16039 | [
"Reactive",
"oxygen",
"intermediates",
"as",
"apparently",
"widely",
"used",
"messengers",
"in",
"the",
"activation",
"of",
"the",
"NF-kappa",
"B",
"transcription",
"factor",
"and",
"HIV-1",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
10,
10,
0,
0,
0
] |
16040 | [
"Hydrogen",
"peroxide",
"and",
"oxygen",
"radicals",
"are",
"agents",
"commonly",
"produced",
"during",
"inflammatory",
"processes",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
16041 | [
"In",
"this",
"study",
",",
"we",
"show",
"that",
"micromolar",
"concentrations",
"of",
"H2O2",
"can",
"induce",
"the",
"expression",
"and",
"replication",
"of",
"HIV-1",
"in",
"a",
"human",
"T",
"cell",
"line",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
5,
6,
6,
6,
0
] |
16042 | [
"The",
"effect",
"is",
"mediated",
"by",
"the",
"NF-kappa",
"B",
"transcription",
"factor",
"which",
"is",
"potently",
"and",
"rapidly",
"activated",
"by",
"an",
"H2O2",
"treatment",
"of",
"cells",
"from",
"its",
"inactive",
"cytoplasmic",
"form",
"."
] | [
0,
0,
0,
0,
0,
0,
9,
10,
10,
10,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
16043 | [
"N-acetyl-L-cysteine",
"(",
"NAC",
")",
",",
"a",
"well",
"characterized",
"antioxidant",
"which",
"counteracts",
"the",
"effects",
"of",
"reactive",
"oxygen",
"intermediates",
"(",
"ROI",
")",
"in",
"living",
"cells",
",",
"prevented",
"the",
"activation",
"of",
"NF-kappa",
"B",
"by",
"H2O2",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
0,
0,
0
] |
16044 | [
"NAC",
"and",
"other",
"thiol",
"compounds",
"also",
"blocked",
"the",
"activation",
"of",
"NF-kappa",
"B",
"by",
"cycloheximide",
",",
"double-stranded",
"RNA",
",",
"calcium",
"ionophore",
",",
"TNF-alpha",
",",
"active",
"phorbol",
"ester",
",",
"interleukin-1",
",",
"lipopolysaccharide",
"and",
"lectin",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
9,
0,
0,
0,
9,
0
] |
16045 | [
"This",
"suggests",
"that",
"diverse",
"agents",
"thought",
"to",
"activate",
"NF-kappa",
"B",
"by",
"distinct",
"intracellular",
"pathways",
"might",
"all",
"act",
"through",
"a",
"common",
"mechanism",
"involving",
"the",
"synthesis",
"of",
"ROI",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
16046 | [
"ROI",
"appear",
"to",
"serve",
"as",
"messengers",
"mediating",
"directly",
"or",
"indirectly",
"the",
"release",
"of",
"the",
"inhibitory",
"subunit",
"I",
"kappa",
"B",
"from",
"NF-kappa",
"B",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
10,
0,
9,
10,
0
] |
16047 | [
"Inhibition",
"of",
"transcription",
"factors",
"belonging",
"to",
"the",
"rel/NF-kappa",
"B",
"family",
"by",
"a",
"transdominant",
"negative",
"mutant",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
9,
10,
10,
0,
0,
0,
0,
0,
0
] |
16048 | [
"The",
"KBF1",
"factor",
",",
"which",
"binds",
"to",
"the",
"enhancer",
"A",
"located",
"in",
"the",
"promoter",
"of",
"the",
"mouse",
"MHC",
"class",
"I",
"gene",
"H-2Kb",
",",
"is",
"indistinguishable",
"from",
"the",
"p50",
"DNA",
"binding",
"subunit",
"of",
"the",
"transcription",
"factor",
"NF-kappa",
"B",
",",
"which",
"regulates",
"a",
"series",
"of",
"genes",
"involved",
"in",
"immune",
"and",
"inflammatory",
"responses",
"."
] | [
0,
9,
10,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
2,
2,
2,
2,
0,
0,
0,
0,
0,
9,
10,
10,
10,
0,
0,
9,
10,
10,
10,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
16049 | [
"The",
"KBF1/p50",
"factor",
"binds",
"as",
"a",
"homodimer",
"but",
"can",
"also",
"form",
"heterodimers",
"with",
"the",
"products",
"of",
"other",
"members",
"of",
"the",
"same",
"family",
",",
"like",
"the",
"c-rel",
"and",
"v-rel",
"(",
"proto",
")",
"oncogenes",
"."
] | [
0,
9,
10,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
0,
1,
2,
2,
2,
2,
0
] |
16050 | [
"The",
"dimerization",
"domain",
"of",
"KBF1/p50",
"is",
"contained",
"between",
"amino",
"acids",
"201",
"and",
"367",
"."
] | [
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
16051 | [
"A",
"mutant",
"of",
"KBF1/p50",
"(",
"delta",
"SP",
")",
",",
"unable",
"to",
"bind",
"to",
"DNA",
"but",
"able",
"to",
"form",
"homo-",
"or",
"heterodimers",
",",
"has",
"been",
"constructed",
"."
] | [
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
16052 | [
"This",
"protein",
"reduces",
"or",
"abolishes",
"in",
"vitro",
"the",
"DNA",
"binding",
"activity",
"of",
"wild-type",
"proteins",
"of",
"the",
"same",
"family",
"(",
"KBF1/p50",
",",
"c-",
"and",
"v-rel",
")",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
9,
0,
9,
0,
0
] |
16053 | [
"This",
"mutant",
"also",
"functions",
"in",
"vivo",
"as",
"a",
"trans-acting",
"dominant",
"negative",
"regulator",
":",
"the",
"transcriptional",
"inducibility",
"of",
"the",
"HIV",
"long",
"terminal",
"repeat",
"(",
"which",
"contains",
"two",
"potential",
"NF-kappa",
"B",
"binding",
"sites",
")",
"by",
"phorbol",
"ester",
"(",
"PMA",
")",
"is",
"inhibited",
"when",
"it",
"is",
"co-transfected",
"into",
"CD4+",
"T",
"cells",
"with",
"the",
"delta",
"SP",
"mutant",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
2,
2,
0,
0,
0,
0,
0,
1,
2,
2,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
7,
8,
0,
0,
0,
0,
0,
0
] |
16054 | [
"Similarly",
"the",
"basal",
"as",
"well",
"as",
"TNF",
"or",
"IL1-induced",
"activity",
"of",
"the",
"MHC",
"class",
"I",
"H-2Kb",
"promoter",
"can",
"be",
"inhibited",
"by",
"this",
"mutant",
"in",
"two",
"different",
"cell",
"lines",
"."
] | [
0,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
1,
2,
2,
2,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
16055 | [
"These",
"results",
"constitute",
"the",
"first",
"formal",
"demonstration",
"that",
"these",
"genes",
"are",
"regulated",
"by",
"members",
"of",
"the",
"rel/NF-kappa",
"B",
"family",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
10,
0
] |
16056 | [
"Tissue-specific",
"expression",
"of",
"the",
"platelet",
"GPIIb",
"gene",
"."
] | [
0,
0,
0,
0,
1,
2,
2,
0
] |
16057 | [
"One",
"of",
"the",
"major",
"objectives",
"in",
"the",
"study",
"of",
"thrombogenesis",
"is",
"to",
"determine",
"the",
"mechanisms",
"by",
"which",
"a",
"hematopoietic",
"progenitor",
"is",
"activated",
"and",
"committed",
"to",
"the",
"megakaryocytic",
"lineage",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
7,
8,
0,
0,
0,
0,
0,
0,
7,
8,
0
] |
16058 | [
"Recent",
"development",
"of",
"primary",
"cultures",
"of",
"human",
"megakaryocytes",
"and",
"the",
"molecular",
"cloning",
"of",
"genes",
"that",
"are",
"specific",
"to",
"this",
"lineage",
"offer",
"the",
"possibility",
"of",
"getting",
"some",
"insights",
"into",
"the",
"genetic",
"mechanisms",
"that",
"control",
"megakaryocytopoiesis",
"."
] | [
0,
0,
0,
0,
0,
0,
7,
8,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
16059 | [
"One",
"gene",
"of",
"interest",
"is",
"the",
"glycoprotein",
"IIb",
"(",
"GPIIb",
")",
"gene",
";",
"GPIIb",
",",
"the",
"alpha",
"subunit",
"of",
"the",
"platelet",
"cytoadhesin",
"GPIIb-IIIa",
",",
"is",
"produced",
"in",
"megakaryocytes",
"at",
"an",
"early",
"stage",
"of",
"the",
"differentiation",
",",
"whereas",
"the",
"other",
"subunit",
"of",
"this",
"complex",
",",
"GPIIIa",
",",
"is",
"expressed",
"in",
"other",
"cells",
"."
] | [
0,
0,
0,
0,
0,
0,
1,
2,
2,
2,
2,
2,
0,
1,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
7,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0
] |
16060 | [
"For",
"these",
"reasons",
",",
"the",
"5'-flanking",
"region",
"of",
"the",
"GPIIb",
"gene",
"was",
"used",
"to",
"identify",
"the",
"regions",
"that",
"interact",
"with",
"DNA-binding",
"nuclear",
"factors",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
16061 | [
"A",
"fragment",
"extending",
"from",
"-643",
"to",
"+33",
"is",
"capable",
"of",
"controlling",
"the",
"tissue-specific",
"expression",
"of",
"the",
"CAT",
"gene",
"in",
"transfection",
"experiments",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
0,
0,
0,
0
] |
16062 | [
"Within",
"this",
"region",
",",
"we",
"have",
"identified",
"several",
"sequences",
"that",
"are",
"implicated",
"in",
"DNA",
"protein",
"interactions",
"as",
"shown",
"in",
"DNAse",
"I",
"footprints",
"and",
"gel",
"mobility",
"shift",
"assays",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
0,
0,
0,
0,
0,
0,
0
] |
16063 | [
"One",
"region",
",",
"centered",
"at",
"-54",
",",
"is",
"similar",
"to",
"a",
"nuclear",
"factor",
"E1-binding",
"site",
",",
"and",
"a",
"region",
"located",
"at",
"position",
"-233",
"contains",
"a",
"CCAAT",
"motif",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
2,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
0
] |
16064 | [
"Two",
"domains",
"centered",
"at",
"positions",
"-345",
"and",
"-540",
",",
"respectively",
",",
"bind",
"proteins",
"that",
"are",
"present",
"in",
"megakaryocytic",
"cells",
"and",
"nonrelated",
"cells",
"as",
"well",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
7,
8,
0,
0,
0,
0,
0,
0
] |
16065 | [
"Finally",
",",
"two",
"other",
"domains",
",",
"located",
"at",
"positions",
"-460",
"and",
"-510",
",",
"interact",
"with",
"proteins",
"that",
"are",
"only",
"present",
"in",
"megakaryocytic",
"cells",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
7,
8,
0
] |
16066 | [
"In",
"addition",
",",
"deletion",
"of",
"the",
"region",
"containing",
"these",
"two",
"domains",
"results",
"in",
"a",
"significant",
"decrease",
"of",
"the",
"promoter",
"activity",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
16067 | [
"It",
"is",
"very",
"likely",
"that",
"these",
"domains",
"bind",
"megakaryocyte-specific",
"nuclear",
"proteins",
"acting",
"as",
"positive",
"transcription",
"factors",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
16068 | [
"Lymphocyte",
"glucocorticoid",
"receptor",
"binding",
"during",
"depression",
"and",
"after",
"clinical",
"recovery",
"."
] | [
7,
9,
10,
0,
0,
0,
0,
0,
0,
0,
0
] |
16069 | [
"Lymphocyte",
"glucocorticoid",
"receptor",
"binding",
"parameters",
"were",
"studied",
"in",
"15",
"severely",
"depressed",
"patients",
"during",
"depression",
"and",
"after",
"clinical",
"recovery",
",",
"and",
"in",
"15",
"healthy",
"controls",
"."
] | [
7,
9,
10,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
16070 | [
"There",
"was",
"no",
"difference",
"in",
"glucocorticoid",
"receptor",
"number",
"or",
"affinity",
"between",
"depressed",
"patients",
"and",
"recovered",
"or",
"control",
"subjects",
"."
] | [
0,
0,
0,
0,
0,
9,
10,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
16071 | [
"Afternoon",
"ACTH",
"and",
"cortisol",
"concentrations",
"did",
"not",
"differ",
"significantly",
"between",
"the",
"three",
"groups",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
16072 | [
"No",
"relationship",
"could",
"be",
"established",
"between",
"glucocorticoid",
"receptor",
"binding",
"and",
"antidepressant",
"medication",
"."
] | [
0,
0,
0,
0,
0,
0,
9,
10,
0,
0,
0,
0,
0
] |
16073 | [
"These",
"data",
"support",
"the",
"view",
"of",
"an",
"impaired",
"ligand-induced",
"plasticity",
"of",
"glucocorticoid",
"receptor",
"regulation",
"rather",
"than",
"the",
"hypothesis",
"of",
"decreased",
"glucocorticoid",
"receptor",
"numbers",
"during",
"depression",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
0,
0,
0,
0,
0,
0,
0,
9,
10,
0,
0,
0,
0
] |
16074 | [
"Every",
"enhancer",
"works",
"with",
"every",
"promoter",
"for",
"all",
"the",
"combinations",
"tested",
":",
"could",
"new",
"regulatory",
"pathways",
"evolve",
"by",
"enhancer",
"shuffling",
"?"
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
16075 | [
"The",
"promoters",
"and",
"enhancers",
"of",
"cell",
"type-specific",
"genes",
"are",
"often",
"conserved",
"in",
"evolution",
",",
"and",
"hence",
"one",
"might",
"expect",
"that",
"a",
"given",
"enhancer",
"has",
"evolved",
"to",
"work",
"best",
"with",
"its",
"own",
"promoter",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
16076 | [
"While",
"this",
"expectation",
"may",
"be",
"realized",
"in",
"some",
"cases",
",",
"we",
"have",
"not",
"found",
"evidence",
"for",
"it",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
16077 | [
"A",
"total",
"of",
"27",
"combinations",
"of",
"different",
"promoters",
"and",
"enhancers",
"were",
"tested",
"by",
"transfection",
"into",
"cultured",
"cells",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
16078 | [
"We",
"found",
"that",
"the",
"relative",
"efficiency",
"of",
"the",
"enhancers",
"is",
"approximately",
"the",
"same",
",",
"irrespective",
"of",
"the",
"type",
"of",
"promoter",
"used",
",",
"i.e.",
",",
"there",
"was",
"no",
"strong",
"preference",
"for",
"any",
"given",
"enhancer/",
"promoter",
"combination",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
16079 | [
"Notably",
",",
"we",
"do",
"not",
"see",
"particularly",
"strong",
"transcription",
"when",
"the",
"immunoglobulin",
"kappa",
"enhancer",
"(",
"or",
"the",
"immunoglobulin",
"heavy",
"chain",
"enhancer",
")",
"is",
"used",
"to",
"activate",
"a",
"kappa",
"gene",
"promoter",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
2,
0,
0,
0,
1,
2,
2,
2,
0,
0,
0,
0,
0,
0,
1,
2,
2,
0
] |
16080 | [
"We",
"propose",
"that",
"a",
"generally",
"permissive",
"enhancer/",
"promoter",
"interaction",
"is",
"of",
"evolutionary",
"benefit",
"for",
"higher",
"eukaryotes",
":",
"by",
"enhancer",
"shuffling",
",",
"genes",
"could",
"be",
"easily",
"brought",
"under",
"a",
"new",
"type",
"of",
"inducibility/cell",
"type",
"specificity",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
16081 | [
"Towards",
"a",
"molecular",
"understanding",
"of",
"T-cell",
"differentiation",
"."
] | [
0,
0,
0,
0,
0,
7,
0,
0
] |
16082 | [
"Lymphoid",
"differentiation",
"is",
"one",
"of",
"the",
"best",
"studied",
"examples",
"of",
"mammalian",
"development",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
16083 | [
"Here",
"Hans",
"Clevers",
"and",
"Michael",
"Owen",
"describe",
"how",
"the",
"cloning",
"of",
"the",
"genes",
"that",
"encode",
"T-cell-specific",
"membrane",
"proteins",
"allows",
"the",
"identification",
"of",
"transcription",
"factors",
"that",
"control",
"the",
"expression",
"of",
"these",
"T-cell",
"genes",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
0
] |
16084 | [
"Such",
"transcription",
"factors",
"play",
"a",
"key",
"role",
"in",
"the",
"development",
"of",
"the",
"mature",
"T-cell",
"phenotype",
"by",
"functioning",
"as",
"'master",
"regulators",
"of",
"T-cell",
"differentiation'",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
7,
0,
0,
0,
0,
0,
0,
0,
7,
0,
0
] |
16085 | [
"A",
"study",
"on",
"the",
"circadian",
"rhythm",
"of",
"glucocorticoid",
"receptor",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
9,
10,
0
] |
16086 | [
"Circadian",
"rhythm",
"in",
"glucocorticoid",
"receptor",
"(",
"GR",
")",
"was",
"studied",
"in",
"the",
"rat",
"liver",
"and",
"human",
"peripheral",
"leukocytes",
"."
] | [
0,
0,
0,
9,
10,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
7,
8,
8,
0
] |
16087 | [
"For",
"rats",
"exposed",
"to",
"a",
"natural",
"environmental",
"photic",
"cycle",
"or",
"a",
"12L",
":",
"12D",
"artificial",
"light",
"regime",
",",
"peak",
"values",
"of",
"hepatic",
"GR",
"were",
"detected",
"between",
"23",
":",
"00",
"and",
"02",
":",
"00",
"h",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
16088 | [
"Except",
"for",
"a",
"4-hour",
"advancement",
"of",
"the",
"peak",
",",
"a",
"similar",
"circadian",
"rhythm",
"of",
"hepatic",
"GR",
"was",
"detected",
"in",
"rats",
"reared",
"under",
"a",
"reversed",
"lighting",
"regimen",
"(",
"12D",
":",
"12L",
";",
"lights",
"on",
"between",
"18",
":",
"30",
"and",
"06",
":",
"30",
"h",
")",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
16089 | [
"In",
"human",
"leukocytes",
",",
"the",
"peak",
"value",
"of",
"GR",
"was",
"found",
"to",
"parallel",
"that",
"of",
"plasma",
"cortisol",
"with",
"high",
"and",
"low",
"values",
"detected",
"at",
"04",
":",
"00-08",
":",
"00",
"h",
"and",
"23",
":",
"00-24",
":",
"00",
"h",
",",
"respectively",
"."
] | [
0,
7,
8,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
16090 | [
"In",
"patients",
"suffering",
"from",
"Cushing",
"'s",
"syndrome",
",",
"the",
"circadian",
"rhythm",
"of",
"plasma",
"cortisol",
"either",
"disappeared",
"or",
"was",
"inverted",
"while",
"that",
"of",
"GR",
"did",
"not",
"significantly",
"deviate",
"from",
"the",
"normal",
"subjects",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
16091 | [
"For",
"apoplexic",
"patients",
"with",
"lesions",
"localized",
"to",
"the",
"base",
"of",
"the",
"brain",
"as",
"indicated",
"by",
"computerized",
"tomography",
",",
"the",
"diurnal",
"variation",
"of",
"GR",
"was",
"abolished",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
0,
0
] |
16092 | [
"Conversely",
",",
"diurnal",
"rhythmicity",
"persisted",
"in",
"apoplexy",
"patients",
"whose",
"lesions",
"were",
"in",
"the",
"cerebral",
"cortex",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
16093 | [
"Thus",
",",
"we",
"postulated",
"that",
"the",
"circadian",
"modification",
"of",
"GR",
"was",
"independent",
"of",
"the",
"diurnal",
"fluctuations",
"in",
"plasma",
"cortisol",
"level",
"or",
"the",
"circadian",
"variations",
"in",
"environmental",
"lighting",
"and",
"that",
"the",
"rhythmicity",
"might",
"be",
"regulated",
"by",
"the",
"'circadian",
"pacemaker",
"'",
"located",
"in",
"the",
"human",
"basal",
"brain",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
16094 | [
"These",
"diurnal",
"variations",
"in",
"GR",
"might",
"serve",
"to",
"coordinate",
"the",
"reactivity",
"of",
"the",
"target",
"cells",
"to",
"cortisol",
"because",
"the",
"diurnal",
"rhythms",
"of",
"a",
"GR",
"-mediated",
"response",
",",
"the",
"fractional",
"inhibition",
"of",
"chemotactic",
"migration",
"rate",
"of",
"polymorphonuclear",
"leukocytes",
"by",
"cortisol",
",",
"were",
"found",
"to",
"be",
"synchronous",
"with",
"those",
"of",
"GR",
"."
] | [
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
7,
8,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0
] |
16095 | [
"Transcription",
"factor",
"requirements",
"for",
"U2",
"snRNA",
"-encoding",
"gene",
"activation",
"in",
"B",
"lymphoid",
"cells",
"."
] | [
0,
0,
0,
0,
3,
4,
0,
0,
0,
0,
7,
8,
8,
0
] |
16096 | [
"Transcription",
"of",
"a",
"human",
"U2",
"small",
"nuclear",
"RNA",
"(",
"snRNA",
")",
"-encoding",
"gene",
"in",
"HeLa",
"cells",
"requires",
"a",
"distal",
"enhancer",
"element",
",",
"which",
"is",
"composed",
"of",
"one",
"octamer",
"motif",
"(",
"Oct",
")",
"and",
"three",
"Sp",
"1-binding",
"sites",
"."
] | [
0,
0,
0,
1,
2,
2,
2,
2,
0,
0,
0,
0,
0,
0,
5,
6,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
0,
0,
0,
1,
2,
2,
0
] |
16097 | [
"To",
"study",
"the",
"transcription",
"factor",
"requirement",
"in",
"B-cells",
",",
"different",
"U2",
"enhancer",
"constructions",
"were",
"transfected",
"into",
"the",
"lymphoid",
"cell",
"line",
",",
"BJA-B",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
7,
0,
0,
1,
2,
0,
0,
0,
0,
0,
5,
6,
6,
0,
5,
0
] |
16098 | [
"The",
"results",
"showed",
"that",
"the",
"activation",
"of",
"U2",
"snRNA",
"transcription",
"in",
"B-cells",
"also",
"requires",
"an",
"enhancer",
"comprising",
"both",
"the",
"Oct",
"and",
"at",
"least",
"one",
"Sp",
"1-binding",
"site",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
3,
4,
0,
0,
7,
0,
0,
0,
0,
0,
0,
0,
1,
0,
0,
0,
0,
1,
2,
2,
0
] |
16099 | [
"Deletion",
"of",
"all",
"the",
"Sp",
"1-binding",
"sites",
"from",
"the",
"enhancer",
"reduces",
"transcription",
"by",
"80-90",
"%",
"in",
"HeLa",
",",
"as",
"well",
"as",
"in",
"BJA-B",
"cells",
",",
"whereas",
"the",
"removal",
"of",
"the",
"octamer-binding",
"site",
"reduces",
"transcription",
"to",
"levels",
"below",
"detection",
"in",
"both",
"cell",
"types",
"."
] | [
0,
0,
0,
0,
1,
2,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0,
5,
0,
0,
0,
0,
0,
5,
6,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
16100 | [
"Enhancers",
"containing",
"a",
"single",
"Oct",
"have",
",",
"nevertheless",
",",
"the",
"capacity",
"to",
"partially",
"activate",
"U2",
"snRNA",
"transcription",
"in",
"both",
"HeLa",
"cells",
",",
"in",
"which",
"only",
"OTF-1",
"is",
"expressed",
",",
"and",
"in",
"BJA-B",
"cells",
"in",
"which",
"OTF-2",
"is",
"the",
"predominantly",
"expressed",
"octamer-binding",
"factor",
"."
] | [
0,
0,
0,
0,
1,
0,
0,
0,
0,
0,
0,
0,
0,
0,
3,
4,
0,
0,
0,
5,
6,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
5,
6,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0
] |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.