id
stringlengths 1
5
| tokens
sequence | ner_tags
sequence |
---|---|---|
15901 | [
"cells/tube",
"in",
"the",
"assay",
"volume",
"0.25",
"ml",
"were",
"found",
"to",
"be",
"optimal",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
15902 | [
"An",
"attempt",
"was",
"also",
"undertaken",
"to",
"use",
"a",
"cell",
"harvester",
"for",
"the",
"separation",
"of",
"cells",
"from",
"unbound",
"ligand",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
15903 | [
"Though",
"specifically",
"bound",
"dexamethasone",
"measured",
"by",
"whole-cell",
"assay",
"and",
"that",
"using",
"cell",
"harvester",
"correlated",
"well",
",",
"almost",
"by",
"one",
"order",
"lower",
"values",
"obtained",
"with",
"the",
"latter",
"method",
"render",
"it",
"non-applicable",
"for",
"receptor",
"quantitation",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
15904 | [
"The",
"results",
"from",
"9",
"healthy",
"volunteers",
"(",
"average",
"GR",
"concentration",
"7131",
"+/-",
"1256",
"sites/cell",
")",
"correlated",
"excellently",
"with",
"those",
"obtained",
"by",
"the",
"Scatchard",
"analysis",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
15905 | [
"The",
"single",
"point",
"assay",
"has",
"been",
"also",
"applied",
"for",
"determination",
"of",
"GH",
"in",
"10",
"children",
"treated",
"with",
"large",
"doses",
"of",
"prednisone",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
15906 | [
"The",
"average",
"values",
"from",
"healthy",
"volunteers",
"did",
"not",
"differ",
"significantly",
"from",
"those",
"found",
"in",
"these",
"children",
",",
"though",
"much",
"broader",
"range",
"was",
"found",
"in",
"patients",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
15907 | [
"Glucocorticoid",
"receptor",
"and",
"inhibition",
"of",
"3-O-methyl-D-glucose",
"uptake",
"by",
"glucocorticoids",
"in",
"peripheral",
"blood",
"leukocytes",
"from",
"normal",
"humans",
":",
"correlation",
"between",
"receptor",
"level",
"and",
"hormone",
"effect",
"in",
"vitro",
"."
] | [
9,
10,
0,
0,
0,
0,
0,
0,
0,
0,
7,
8,
8,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
15908 | [
"We",
"have",
"measured",
"the",
"glucocorticoid",
"receptor",
"concentration",
"in",
"mononuclear",
"and",
"polymorphonuclear",
"leukocytes",
",",
"both",
"of",
"which",
"were",
"isolated",
"from",
"peripheral",
"blood",
"from",
"ten",
"healthy",
"male",
"volunteers",
"."
] | [
0,
0,
0,
0,
9,
10,
0,
0,
0,
0,
7,
8,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
15909 | [
"In",
"parallel",
",",
"the",
"inhibitory",
"effect",
"of",
"dexamethasone",
"on",
"3-O-methyl-D-glucose",
"uptake",
"was",
"assayed",
"in",
"the",
"corresponding",
"mononuclear",
"leukocytes",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
7,
8,
0
] |
15910 | [
"The",
"glucocorticoid",
"receptor",
"levels",
"in",
"mononuclear",
"leukocytes",
"correlated",
"with",
"those",
"in",
"polymorphonuclear",
"leukocytes",
",",
"and",
"there",
"was",
"a",
"linear",
"relationship",
"between",
"the",
"cellular",
"glucocorticoid",
"receptor",
"levels",
"and",
"glucocorticoid-mediated",
"inhibition",
"of",
"the",
"uptake",
"of",
"3-O-methyl-D-glucose",
"in",
"mononuclear",
"leukocytes",
"."
] | [
0,
9,
10,
0,
0,
7,
8,
0,
0,
0,
0,
7,
8,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
7,
8,
0
] |
15911 | [
"When",
"mononuclear",
"leukocytes",
"were",
"incubated",
"in",
"the",
"presence",
"of",
"8-bromo-cAMP",
",",
"cellular",
"glucocorticoid",
"receptor",
"levels",
"increased",
"and",
"a",
"more",
"pronounced",
"inhibitory",
"effect",
"of",
"dexamethasone",
"was",
"observed",
"on",
"the",
"transport",
"of",
"3-O-methyl-D-glucose",
"."
] | [
0,
7,
8,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
15912 | [
"We",
"conclude",
"that",
"the",
"cellular",
"glucocorticoid",
"receptor",
"levels",
"in",
"peripheral",
"blood",
"leukocytes",
"reflect",
"in",
"vitro",
"responsiveness",
"to",
"glucocorticoids",
"in",
"mononuclear",
"leukocytes",
"from",
"healthy",
"males",
",",
"and",
"that",
"the",
"individual",
"responsiveness",
"may",
"alter",
"upon",
"changes",
"in",
"the",
"cellular",
"levels",
"of",
"glucocorticoid",
"receptor",
"."
] | [
0,
0,
0,
0,
0,
9,
10,
0,
0,
7,
8,
8,
0,
0,
0,
0,
0,
0,
0,
7,
8,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
0
] |
15913 | [
"Transcription",
"factor",
"activation",
"and",
"functional",
"stimulation",
"of",
"human",
"monocytes",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
7,
8,
0
] |
15914 | [
"Activation",
"of",
"expression",
"of",
"genes",
"encoding",
"transcription",
"factors",
":",
"c-fos",
"and",
"c-jun",
"and",
"formation",
"of",
"AP1",
"transcriptional",
"complex",
"in",
"human",
"monocytes",
"was",
"investigated",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
9,
0,
0,
0,
9,
10,
10,
0,
7,
8,
0,
0,
0
] |
15915 | [
"It",
"was",
"found",
"that",
"lipopolysaccharide",
"induced",
"strongly",
"both",
"c-fos",
"and",
"c-jun",
"expression",
"as",
"well",
"as",
"AP1",
"formation",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
9,
0,
0,
0,
0,
9,
0,
0
] |
15916 | [
"Interferon",
"gamma",
"activated",
"strongly",
"c-fos",
"and",
"weakly",
"c-jun",
"and",
"AP1",
"."
] | [
9,
10,
0,
0,
9,
0,
0,
9,
0,
9,
0
] |
15917 | [
"Tumor",
"necrosis",
"factor",
"induced",
"slightly",
"c-fos",
"and",
"had",
"almost",
"no",
"effect",
"on",
"c-jun",
"and",
"AP1",
"."
] | [
9,
10,
10,
0,
0,
9,
0,
0,
0,
0,
0,
0,
9,
0,
9,
0
] |
15918 | [
"The",
"data",
"suggest",
"that",
"differences",
"in",
"functional",
"responses",
"elicited",
"in",
"monocytes",
"by",
"all",
"three",
"factors",
"may",
"be",
"dependent",
"on",
"different",
"routes",
"on",
"nuclear",
"signalling",
"employed",
"by",
"the",
"factors",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
7,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
15919 | [
"Regulation",
"of",
"interleukin-1",
"beta",
"production",
"by",
"glucocorticoids",
"in",
"human",
"monocytes",
":",
"the",
"mechanism",
"of",
"action",
"depends",
"on",
"the",
"activation",
"signal",
"."
] | [
0,
0,
9,
10,
0,
0,
0,
0,
7,
8,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
15920 | [
"Glucocorticoids",
"are",
"known",
"to",
"downregulate",
"interleukin-1",
"beta",
"production",
"in",
"monocytic",
"cells",
"by",
"two",
"different",
"mechanims",
":",
"direct",
"inhibition",
"of",
"the",
"gene",
"transcription",
"and",
"destabilization",
"of",
"the",
"preformed",
"interleukin-1",
"beta",
"mRNA",
"."
] | [
0,
0,
0,
0,
0,
9,
10,
0,
0,
7,
8,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
3,
4,
4,
0
] |
15921 | [
"Now",
"we",
"have",
"examined",
"the",
"effect",
"of",
"the",
"nature",
"of",
"the",
"monocyte",
"activating",
"signal",
"on",
"these",
"two",
"inhibitory",
"mechanims",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
15922 | [
"When",
"human",
"monocytes",
"were",
"preincubated",
"with",
"dexamethasone",
"for",
"1",
"hour",
"and",
"then",
"stimulated",
"either",
"with",
"bacterial",
"lipopolysaccharide",
"or",
"phorbol",
"myristate",
",",
"it",
"was",
"found",
"that",
"dexamethasone",
"inhibited",
"the",
"lipopolysaccharide-induced",
"interleukin-1",
"beta",
"protein",
"production",
",",
"but",
"the",
"phorbol",
"myristate-induced",
"production",
"was",
"increased",
"3-10",
"fold",
"."
] | [
0,
7,
8,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
10,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
15923 | [
"This",
"difference",
"was",
"also",
"seen",
"at",
"the",
"mRNA",
"level",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
15924 | [
"When",
"dexamethasone",
"was",
"added",
"to",
"the",
"cultures",
"3",
"hours",
"after",
"the",
"stimulators",
",",
"it",
"clearly",
"decreased",
"the",
"interleukin-1",
"beta",
"mRNA",
"levels",
"regardless",
"of",
"the",
"stimulator",
"used",
"(",
"although",
"the",
"effect",
"was",
"clearly",
"weaker",
"on",
"the",
"PMA-induced",
"mRNA",
")",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
3,
4,
4,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
15925 | [
"Thus",
"these",
"data",
"suggest",
"that",
"the",
"phorbol",
"myristate-induced",
"signal",
"(",
"prolonged",
"protein",
"kinase",
"C",
"activation",
"?",
")",
"can",
"not",
"be",
"inhibited",
"by",
"prior",
"incubation",
"with",
"dexamethasone",
"and",
"it",
"also",
"protects",
"the",
"induced",
"mRNA",
"for",
"the",
"degradative",
"action",
"of",
"dexamethasone",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
10,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
15926 | [
"Nuclear",
"transcription",
"factors",
"that",
"bind",
"to",
"elements",
"of",
"the",
"IL-2",
"promoter",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
0
] |
15927 | [
"Induction",
"requirements",
"in",
"primary",
"human",
"T",
"cells",
"."
] | [
0,
0,
0,
0,
7,
8,
8,
0
] |
15928 | [
"Prior",
"studies",
"have",
"identified",
"several",
"elements",
"that",
"contribute",
"to",
"the",
"activity",
"of",
"the",
"IL-2",
"promoter",
"in",
"the",
"stimulated",
"T",
"cell",
"line",
",",
"Jurkat",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
0,
0,
0,
5,
6,
6,
0,
5,
0
] |
15929 | [
"The",
"sites",
"and",
"their",
"corresponding",
"nuclear",
"binding",
"factors",
"include",
":",
"NF-kappa",
"B",
",",
"AP-1",
",",
"AP-3",
",",
"OCT-1",
",",
"and",
"NF-AT",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
0,
9,
0,
9,
0,
9,
0,
0,
9,
0
] |
15930 | [
"The",
"latter",
"``",
"nuclear",
"factor",
"for",
"activated",
"T",
"cells",
"``",
"likely",
"contributes",
"to",
"the",
"tissue",
"specificity",
"of",
"IL-2",
"gene",
"expression",
"."
] | [
0,
0,
0,
9,
10,
10,
10,
10,
10,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
0,
0
] |
15931 | [
"Using",
"electrophoretic",
"mobility",
"shift",
"assays",
",",
"we",
"have",
"studied",
"these",
"transcription",
"factors",
"in",
"primary",
"T",
"cells",
"from",
"human",
"blood",
"to",
"verify",
"their",
"presence",
"in",
"a",
"physiologic",
"setting",
"and",
"to",
"identify",
"the",
"signals",
"that",
"stimulate",
"factor",
"activity",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
7,
8,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
15932 | [
"All",
"factors",
"are",
"induced",
"in",
"the",
"nuclei",
"of",
"T",
"cells",
"upon",
"activation",
"with",
"mitogens",
"but",
"not",
"with",
"exogenous",
"IL-2",
"growth",
"factor",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
7,
8,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
10,
0
] |
15933 | [
"However",
",",
"the",
"signaling",
"requirements",
"and",
"sensitivity",
"to",
"protein",
"synthesis",
"inhibitors",
"differ",
"considerably",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
15934 | [
"Only",
"the",
"activities",
"for",
"NF-AT",
"and",
"AP-1",
"sites",
"require",
"two",
"signals",
"for",
"optimal",
"induction",
",",
"i.e.",
",",
"PMA",
"plus",
"either",
"lectin",
"or",
"antibody",
"to",
"the",
"CD3",
"or",
"CD28",
"surface",
"molecules",
"."
] | [
0,
0,
0,
0,
1,
0,
1,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
9,
0,
9,
10,
10,
0
] |
15935 | [
"Other",
"factors",
"are",
"induced",
"by",
"lectin",
",",
"antibody",
",",
"and/or",
"PMA",
"alone",
"."
] | [
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0
] |
15936 | [
"After",
"appropriate",
"stimulation",
",",
"both",
"NF-AT",
"and",
"AP-1",
"are",
"peculiarly",
"sensitive",
"to",
"the",
"protein",
"synthesis",
"inhibitor",
"anisomycin",
"."
] | [
0,
0,
0,
0,
0,
9,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
15937 | [
"Our",
"data",
"correlate",
"the",
"activity",
"of",
"NF-AT",
"and",
"AP-1",
"in",
"gel",
"shift",
"assays",
"with",
"the",
"two",
"signals",
"requirements",
"for",
"IL-2",
"gene",
"expression",
"."
] | [
0,
0,
0,
0,
0,
0,
9,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
0,
0
] |
15938 | [
"NF-kappa",
"B",
"activity",
"in",
"T",
"cells",
"stably",
"expressing",
"the",
"Tax",
"protein",
"of",
"human",
"T",
"cell",
"lymphotropic",
"virus",
"type",
"I",
"."
] | [
9,
10,
0,
0,
7,
8,
0,
0,
0,
9,
10,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
15939 | [
"The",
"effect",
"of",
"constitutive",
"Tax",
"expression",
"on",
"the",
"interaction",
"of",
"NF-kappa",
"B",
"with",
"its",
"recognition",
"sequence",
"and",
"on",
"NF-kappa",
"B",
"-dependent",
"gene",
"expression",
"was",
"examined",
"in",
"T",
"lymphoid",
"Jurkat",
"cell",
"lines",
"(",
"19D",
"and",
"9J",
")",
"stably",
"transformed",
"with",
"a",
"Tax",
"expression",
"vector",
"."
] | [
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
9,
10,
0,
0,
0,
0,
0,
0,
1,
2,
2,
2,
0,
0,
0,
0,
5,
6,
6,
6,
6,
0,
5,
0,
5,
0,
0,
0,
0,
0,
1,
2,
2,
0
] |
15940 | [
"Tax",
"expressing",
"T",
"cell",
"lines",
"contained",
"a",
"constitutive",
"level",
"of",
"NF-kappa",
"B",
"binding",
"activity",
",",
"detectable",
"by",
"mobility",
"shift",
"assay",
"and",
"uv",
"cross-linking",
"using",
"a",
"palindromic",
"NF-kappa",
"B",
"probe",
"homologous",
"to",
"the",
"interferon",
"beta",
"PRDII",
"site",
"."
] | [
9,
0,
5,
6,
6,
0,
0,
0,
0,
0,
9,
10,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
2,
0,
0,
0,
1,
2,
2,
2,
0
] |
15941 | [
"In",
"Jurkat",
"and",
"NC2.10",
"induction",
"with",
"phorbol",
"esters",
"resulted",
"in",
"the",
"appearance",
"of",
"new",
"DNA",
"binding",
"proteins",
"of",
"85",
",",
"75",
",",
"and",
"54",
"kDa",
",",
"whereas",
"in",
"Tax",
"expressing",
"cells",
"the",
"85-kDa",
"protein",
"and",
"a",
"92-kDa",
"DNA",
"binding",
"protein",
"were",
"constitutively",
"induced",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
15942 | [
"Expression",
"of",
"Tax",
"protein",
"in",
"19D",
"and",
"9J",
"resulted",
"in",
"transcription",
"of",
"the",
"endogenous",
"NF-kappa",
"B-dependent",
"granulocyte-macrophage",
"colony",
"stimulating",
"factor",
"gene",
"and",
"increased",
"basal",
"level",
"expression",
"of",
"transfected",
"NF-kappa",
"B-regulated",
"promoters",
"."
] | [
0,
0,
9,
10,
0,
5,
0,
5,
0,
0,
0,
0,
0,
0,
1,
2,
2,
2,
2,
2,
2,
0,
0,
0,
0,
0,
0,
0,
1,
2,
2,
0
] |
15943 | [
"Nonetheless",
"transcription",
"of",
"both",
"the",
"endogenous",
"and",
"the",
"transfected",
"gene",
"was",
"inducible",
"by",
"PMA",
"treatment",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
15944 | [
"Tax",
"expression",
"in",
"Jurkat",
"T",
"cells",
"may",
"alter",
"the",
"stoichiometry",
"of",
"NF-kappa",
"B",
"DNA",
"binding",
"proteins",
"and",
"thus",
"change",
"the",
"expression",
"of",
"NF-kappa",
"B-regulated",
"promoters",
"."
] | [
9,
0,
0,
5,
6,
6,
0,
0,
0,
0,
0,
9,
10,
10,
10,
10,
0,
0,
0,
0,
0,
0,
1,
2,
2,
0
] |
15945 | [
"A",
"nuclear",
"factor",
"NF-GM2",
"that",
"interacts",
"with",
"a",
"regulatory",
"region",
"of",
"the",
"GM-CSF",
"gene",
"essential",
"for",
"its",
"induction",
"in",
"responses",
"to",
"T-cell",
"activation",
":",
"purification",
"from",
"human",
"T-cell",
"leukemia",
"line",
"Jurkat",
"cells",
"and",
"similarity",
"to",
"NF-kappa",
"B",
"."
] | [
0,
9,
10,
10,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
0,
0,
0,
0,
0,
0,
0,
7,
0,
0,
0,
0,
5,
6,
6,
6,
6,
6,
0,
0,
0,
9,
10,
0
] |
15946 | [
"Activation",
"of",
"T",
"cells",
"by",
"antigen",
",",
"lectin",
",",
"or",
"a",
"combination",
"of",
"phorbol-12-myristate",
"acetate",
"(",
"PMA",
")",
"and",
"calcium",
"ionophore",
"(",
"A23187",
")",
"leads",
"to",
"the",
"induction",
"of",
"genes",
"for",
"a",
"set",
"of",
"lymphokines",
",",
"including",
"granulocyte-macrophage",
"colony-stimulating",
"factor",
"(",
"GM-CSF",
")",
"."
] | [
0,
0,
7,
8,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
10,
0,
9,
0,
0
] |
15947 | [
"We",
"demonstrated",
"in",
"earlier",
"studies",
"that",
"the",
"upstream",
"region",
"of",
"the",
"mouse",
"GM-CSF",
"promoter",
"at",
"positions",
"between",
"-95",
"and",
"-73",
"is",
"essential",
"for",
"transcriptional",
"activation",
"in",
"response",
"to",
"PMA/A23187",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
15948 | [
"This",
"region",
"contains",
"two",
"DNA-binding",
"motifs",
",",
"GM2",
"and",
"GC-box",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
15949 | [
"The",
"GM2",
"sequence",
"(",
"GGTAGTTCCC",
")",
"is",
"recognized",
"by",
"an",
"inducible",
"factor",
"NF-GM2",
";",
"the",
"other",
"(",
"CCGCCC",
")",
"by",
"constitutive",
"factors",
"A1",
",",
"A2",
",",
"and",
"B",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
15950 | [
"To",
"elucidate",
"the",
"mechanism",
"of",
"GM-CSF",
"gene",
"activation",
",",
"we",
"have",
"purified",
"the",
"inducible",
"factor",
"NF-GM2",
"from",
"the",
"nuclear",
"extract",
"of",
"stimulated",
"Jurkat",
"cells",
"on",
"the",
"basis",
"of",
"specific",
"DNA-binding",
"activity",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
0,
0,
0,
0,
0,
0,
5,
6,
0,
0,
0,
0,
0,
0,
0,
0
] |
15951 | [
"The",
"purified",
"NF-GM2",
"consists",
"of",
"50",
"(",
"p50",
")",
"and",
"65",
"kDa",
"(",
"p65",
")",
"polypeptides",
"and",
"has",
"a",
"binding",
"activity",
"specific",
"for",
"both",
"the",
"GM-CSF",
"and",
"immunoglobulin",
"kappa",
"(",
"GGAAAGTCCC",
")",
"enhancers",
"."
] | [
0,
0,
9,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
1,
2,
0,
0,
0,
1,
0
] |
15952 | [
"Electrophoretically",
"purified",
"p50",
"alone",
"can",
"form",
"a",
"protein-DNA",
"complex",
",",
"but",
"in",
"the",
"mixture",
",",
"p50",
"associates",
"preferentially",
"with",
"p65",
"to",
"form",
"the",
"NF-GM2",
"complex",
"."
] | [
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
0,
0,
9,
0,
0,
0,
9,
10,
0
] |
15953 | [
"In",
"addition",
",",
"p65",
"gave",
"per",
"se",
",",
"with",
"low",
"affinity",
",",
"a",
"protein-DNA",
"complex",
"that",
"migrated",
"more",
"slowly",
"than",
"native",
"NF-GM2",
"complex",
"."
] | [
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
0
] |
15954 | [
"Furthermore",
",",
"an",
"antiserum",
"against",
"KBF1",
"(",
"identical",
"to",
"50",
"kDa",
"NF-kappa",
"B",
"protein",
")",
"reacted",
"with",
"the",
"p50",
"of",
"NF-GM2",
",",
"indicating",
"that",
"the",
"NF-GM2",
"polypeptide",
"can",
"not",
"be",
"immunologically",
"differentiated",
"from",
"the",
"50",
"kDa",
"subunit",
"of",
"NF-kappa",
"B",
"."
] | [
0,
0,
0,
0,
0,
9,
0,
0,
0,
9,
10,
10,
10,
10,
0,
0,
0,
0,
9,
0,
9,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
0
] |
15955 | [
"The",
"purified",
"NF-GM2",
"activated",
"in",
"vitro",
"transcription",
"from",
"the",
"kappa",
"B",
"enhancer",
",",
"while",
"it",
"failed",
"to",
"stimulate",
"transcription",
"from",
"the",
"GM-CSF",
"promoter",
"harboring",
"the",
"GM2",
"sequence",
"."
] | [
0,
0,
9,
0,
0,
0,
0,
0,
0,
1,
2,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
0,
0,
0,
0,
0
] |
15956 | [
"This",
"suggests",
"that",
"the",
"activation",
"mechanism",
"of",
"the",
"GM-CSF",
"gene",
"through",
"the",
"GM2/GC-box",
"sequence",
"is",
"different",
"from",
"that",
"of",
"genes",
"carrying",
"the",
"kappa",
"B",
"enhancer",
"alone",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
2,
0,
0
] |
15957 | [
"Characterization",
"of",
"an",
"immediate-early",
"gene",
"induced",
"in",
"adherent",
"monocytes",
"that",
"encodes",
"I",
"kappa",
"B",
"-like",
"activity",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
7,
0,
0,
9,
10,
10,
0,
0,
0
] |
15958 | [
"We",
"have",
"cloned",
"a",
"group",
"of",
"cDNAs",
"representing",
"mRNAs",
"that",
"are",
"rapidly",
"induced",
"following",
"adherence",
"of",
"human",
"monocytes",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
7,
8,
0
] |
15959 | [
"One",
"of",
"the",
"induced",
"transcripts",
"(",
"MAD-3",
")",
"encodes",
"a",
"protein",
"of",
"317",
"amino",
"acids",
"with",
"one",
"domain",
"containing",
"five",
"tandem",
"repeats",
"of",
"the",
"cdc10/ankyrin",
"motif",
",",
"which",
"is",
"60",
"%",
"similar",
"(",
"46",
"%",
"identical",
")",
"to",
"the",
"ankyrin",
"repeat",
"region",
"of",
"the",
"precursor",
"of",
"NF-kappa",
"B/KBF1",
"p50",
"."
] | [
0,
0,
0,
0,
0,
0,
3,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
9,
10,
10,
0
] |
15960 | [
"The",
"C-terminus",
"has",
"a",
"putative",
"protein",
"kinase",
"C",
"phosphorylation",
"site",
"."
] | [
0,
0,
0,
0,
0,
9,
10,
10,
0,
0,
0
] |
15961 | [
"In",
"vitro",
"translated",
"MAD-3",
"protein",
"was",
"found",
"to",
"specifically",
"inhibit",
"the",
"DNA-binding",
"activity",
"of",
"the",
"p50/p65",
"NF-kappa",
"B",
"complex",
"but",
"not",
"that",
"of",
"the",
"p50/p50",
"KBF1",
"factor",
"or",
"of",
"other",
"DNA-binding",
"proteins",
"."
] | [
0,
0,
0,
9,
10,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
10,
10,
0,
0,
0,
0,
0,
9,
10,
10,
0,
0,
0,
0,
0,
0
] |
15962 | [
"The",
"MAD-3",
"cDNA",
"encodes",
"an",
"I",
"kappa",
"B-like",
"protein",
"that",
"is",
"likely",
"to",
"be",
"involved",
"in",
"regulation",
"of",
"transcriptional",
"responses",
"to",
"NF-kappa",
"B",
",",
"including",
"adhesion-dependent",
"pathways",
"of",
"monocyte",
"activation",
"."
] | [
0,
1,
2,
0,
0,
9,
10,
10,
10,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
0,
0,
0,
0,
0,
7,
0,
0
] |
15963 | [
"Cortivazol",
"mediated",
"induction",
"of",
"glucocorticoid",
"receptor",
"messenger",
"ribonucleic",
"acid",
"in",
"wild-type",
"and",
"dexamethasone-resistant",
"human",
"leukemic",
"(",
"CEM",
")",
"cells",
"."
] | [
0,
0,
0,
0,
3,
4,
4,
4,
4,
0,
0,
0,
0,
0,
0,
0,
5,
0,
0,
0
] |
15964 | [
"Cortivazol",
"is",
"a",
"phenylpyrazolo",
"glucocorticoid",
"of",
"high",
"potency",
"and",
"unusual",
"structure",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
15965 | [
"In",
"both",
"wild-type",
"and",
"highly",
"dexamethasone",
"(",
"dex",
")",
"-resistant",
"clones",
"of",
"the",
"human",
"leukemic",
"cell",
"line",
"CEM",
",",
"exposure",
"to",
"cortivazol",
"leads",
"to",
"cell",
"death",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
5,
6,
6,
6,
6,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
15966 | [
"It",
"has",
"been",
"shown",
"recently",
"that",
"in",
"wild-type",
"CEM",
"cells",
"but",
"not",
"in",
"a",
"dex-resistant",
",",
"glucocorticoid",
"receptor",
"(",
"GR",
")",
"-defective",
"clone",
"ICR-27",
"TK-3",
",",
"dex",
"induces",
"GR",
"mRNA",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
5,
6,
0,
0,
0,
0,
0,
0,
9,
10,
0,
9,
0,
0,
0,
5,
6,
0,
0,
0,
3,
4,
0
] |
15967 | [
"To",
"test",
"the",
"hypothesis",
"that",
"cortivazol",
"acts",
"in",
"dex-resistant",
"cells",
"by",
"making",
"use",
"of",
"the",
"residual",
"GR",
"found",
"there",
",",
"wild-type",
"and",
"dex-resistant",
"clones",
"were",
"treated",
"with",
"various",
"concentrations",
"of",
"cortivazol",
"and",
"induction",
"of",
"GR",
"mRNA",
"was",
"studied",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
3,
4,
0,
0,
0
] |
15968 | [
"Cortivazol",
"significantly",
"induced",
"GR",
"mRNA",
"in",
"the",
"normal",
"CEM-C7",
"as",
"well",
"as",
"in",
"two",
"classes",
"of",
"dex-resistant",
"clones",
",",
"although",
"the",
"dex-resistant",
"clones",
"needed",
"at",
"least",
"10",
"times",
"more",
"cortivazol",
"than",
"the",
"normal",
"cells",
"for",
"significant",
"GR",
"mRNA",
"induction",
"."
] | [
0,
0,
0,
3,
4,
0,
0,
0,
5,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
3,
4,
0,
0
] |
15969 | [
"Increased",
"levels",
"of",
"GR",
"mRNA",
"were",
"noticed",
"as",
"early",
"as",
"3",
"h",
"after",
"treatment",
"."
] | [
0,
0,
0,
3,
4,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
15970 | [
"A",
"general",
"correlation",
"between",
"induction",
"of",
"GR",
"mRNA",
"and",
"lysis",
"of",
"the",
"normal",
"and",
"dex-resistant",
"cells",
"was",
"found",
"."
] | [
0,
0,
0,
0,
0,
0,
3,
4,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
15971 | [
"Positive",
"induction",
"of",
"GR",
"mRNA",
"might",
"be",
"one",
"of",
"the",
"earliest",
"crucial",
"steps",
"in",
"the",
"lysis",
"of",
"normal",
"and",
"dex-resistant",
"CEM",
"cells",
",",
"or",
"might",
"serve",
"as",
"a",
"marker",
"for",
"the",
"process",
"."
] | [
0,
0,
0,
3,
4,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
5,
6,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
15972 | [
"However",
",",
"the",
"lysis",
"pathway",
"in",
"the",
"dex-resistant",
"cells",
"is",
"defective",
"in",
"that",
"dex-resistant",
"clones",
"needed",
"significantly",
"more",
"cortivazol",
"than",
"the",
"normal",
"cells",
"for",
"lysis",
"of",
"the",
"cells",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
15973 | [
"HIV",
"enhancer",
"activity",
"perpetuated",
"by",
"NF-kappa",
"B",
"induction",
"on",
"infection",
"of",
"monocytes",
"[",
"see",
"comments",
"]"
] | [
1,
2,
0,
0,
0,
9,
10,
0,
0,
0,
0,
7,
0,
0,
0,
0
] |
15974 | [
"Permissiveness",
"to",
"replication",
"of",
"human",
"immunodeficiency",
"virus",
"(",
"HIV",
")",
"differs",
"in",
"T",
"lymphocytes",
"and",
"macrophages",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
7,
8,
0,
7,
0
] |
15975 | [
"In",
"T",
"cells",
",",
"HIV",
"transcription",
"is",
"poorly",
"detected",
"in",
"vivo",
"."
] | [
0,
7,
8,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
15976 | [
"Cloned",
",",
"normal",
"T",
"lymphocytes",
"show",
"very",
"little",
",",
"if",
"any",
",",
"basal",
"activity",
"of",
"the",
"HIV",
"enhancer",
"and",
"low",
"nuclear",
"expression",
"of",
"NF-kappa",
"B",
",",
"a",
"potent",
"transcriptional",
"activator",
"of",
"the",
"HIV",
"enhancer",
"."
] | [
0,
0,
0,
7,
8,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
0,
0,
0,
0,
0,
9,
10,
0,
0,
0,
0,
0,
0,
0,
1,
2,
0
] |
15977 | [
"In",
"contrast",
",",
"fixed",
"tissue",
"macrophages",
"express",
"detectable",
"HIV",
"proteins",
",",
"indicating",
"permanent",
"virus",
"transcription",
"."
] | [
0,
0,
0,
0,
0,
7,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
15978 | [
"One",
"explanation",
"for",
"the",
"perpetuation",
"of",
"virus",
"infection",
"in",
"macrophages",
"could",
"be",
"sustained",
"nuclear",
"NF-kappa",
"B",
"expression",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
7,
0,
0,
0,
0,
9,
10,
0,
0
] |
15979 | [
"However",
",",
"the",
"U937",
"monocytic",
"cell",
"line",
",",
"which",
"is",
"fully",
"permissive",
"to",
"HIV",
"replication",
",",
"is",
"known",
"to",
"express",
"only",
"low",
"levels",
"of",
"nuclear",
"NF-kappa",
"B",
"."
] | [
0,
0,
0,
5,
6,
6,
6,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
0
] |
15980 | [
"We",
"show",
"here",
"that",
"chronic",
"HIV",
"infection",
"results",
"in",
"both",
"induction",
"of",
"a",
"nuclear",
"factor",
"with",
"antigenic",
"properties",
"indistinguishable",
"from",
"those",
"of",
"NF-kappa",
"B",
"and",
"permanently",
"increased",
"HIV",
"enhancer",
"activity",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
0,
0,
0,
1,
2,
0,
0
] |
15981 | [
"This",
"phenomenon",
",",
"which",
"is",
"independent",
"of",
"tumour",
"necrosis",
"factor",
",",
"is",
"associated",
"with",
"HIV",
"replication",
",",
"and",
"is",
"thus",
"likely",
"to",
"explain",
"at",
"least",
"in",
"part",
"the",
"perpetuation",
"of",
"HIV",
"infection",
"in",
"monocytes",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
9,
10,
10,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
7,
0
] |
15982 | [
"Isolation",
"of",
"a",
"rel-related",
"human",
"cDNA",
"that",
"potentially",
"encodes",
"the",
"65-kD",
"subunit",
"of",
"NF-kappa",
"B",
"[",
"published",
"erratum",
"appears",
"in",
"Science",
"1991",
"Oct",
"4",
";",
"254",
"(",
"5028",
")",
":",
"11",
"]"
] | [
0,
0,
0,
1,
2,
2,
0,
0,
0,
0,
0,
0,
0,
9,
10,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
15983 | [
"A",
"DNA",
"probe",
"that",
"spanned",
"a",
"domain",
"conserved",
"among",
"the",
"proto-oncogene",
"c-rel",
",",
"the",
"Drosophila",
"morphogen",
"dorsal",
",",
"and",
"the",
"p50",
"DNA",
"binding",
"subunit",
"of",
"NF-kappa",
"B",
"was",
"generated",
"from",
"Jurkat",
"T",
"cell",
"complementary",
"DNA",
"with",
"the",
"polymerase",
"chain",
"reaction",
"(",
"PCR",
")",
"and",
"degenerate",
"oligonucleotides",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
10,
10,
0,
9,
10,
0,
0,
0,
5,
6,
6,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
15984 | [
"This",
"probe",
"was",
"used",
"to",
"identify",
"a",
"rel-related",
"complementary",
"DNA",
"that",
"hybridized",
"to",
"a",
"2.6-kilobase",
"messenger",
"RNA",
"present",
"in",
"human",
"T",
"and",
"B",
"lymphocytes",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
1,
2,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0,
7,
8,
8,
8,
8,
0
] |
15985 | [
"In",
"vitro",
"transcription",
"and",
"translation",
"of",
"the",
"complementary",
"DNA",
"resulted",
"in",
"the",
"synthesis",
"of",
"a",
"protein",
"with",
"an",
"apparent",
"molecular",
"size",
"of",
"65",
"kilodaltons",
"(",
"kD",
")",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
15986 | [
"The",
"translated",
"protein",
"showed",
"weak",
"DNA",
"binding",
"with",
"a",
"specificity",
"for",
"the",
"kappa",
"B",
"binding",
"motif",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
15987 | [
"This",
"protein-DNA",
"complex",
"comigrated",
"with",
"the",
"complex",
"obtained",
"with",
"the",
"purified",
"human",
"p65",
"NF-kappa",
"B",
"subunit",
"and",
"binding",
"was",
"inhibited",
"by",
"I",
"kappa",
"B-alpha",
"and",
"-beta",
"proteins",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
10,
10,
10,
0,
0,
0,
0,
0,
9,
10,
10,
0,
9,
10,
0
] |
15988 | [
"In",
"addition",
",",
"the",
"65-kD",
"protein",
"associated",
"with",
"the",
"p50",
"subunit",
"of",
"NF-kappa",
"B",
"and",
"the",
"kappa",
"B",
"probe",
"to",
"form",
"a",
"complex",
"with",
"the",
"same",
"electrophoretic",
"mobility",
"as",
"the",
"NF-kappa",
"B-DNA",
"complex",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
0,
9,
10,
0,
0,
1,
2,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
15989 | [
"Therefore",
"the",
"rel-related",
"65-kD",
"protein",
"may",
"represent",
"the",
"p65",
"subunit",
"of",
"the",
"active",
"NF-kappa",
"B",
"transcription",
"factor",
"complex",
"."
] | [
0,
0,
9,
10,
10,
0,
0,
0,
9,
10,
0,
0,
0,
9,
10,
10,
10,
10,
0
] |
15990 | [
"The",
"human",
"myelomonocytic",
"cell",
"line",
"U-937",
"as",
"a",
"model",
"for",
"studying",
"alterations",
"in",
"steroid-induced",
"monokine",
"gene",
"expression",
":",
"marked",
"enhancement",
"of",
"lipopolysaccharide-stimulated",
"interleukin-1",
"beta",
"messenger",
"RNA",
"levels",
"by",
"1",
",",
"25-dihydroxyvitamin",
"D3",
"."
] | [
0,
5,
6,
6,
6,
6,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
3,
4,
4,
4,
0,
0,
0,
0,
0,
0,
0
] |
15991 | [
"The",
"active",
"metabolite",
"of",
"vitamin",
"D",
",",
"1",
",",
"25-dihydroxyvitamin",
"D3",
"[",
"1",
",",
"25-",
"(",
"OH",
")",
"2D3",
"]",
",",
"is",
"a",
"potent",
"regulator",
"of",
"human",
"monocyte/macrophage",
"function",
"in",
"vitro",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
15992 | [
"To",
"establish",
"a",
"model",
"for",
"1",
",",
"25-",
"(",
"OH",
")",
"2D3",
"regulation",
"of",
"human",
"monocyte",
"monokine",
"synthesis",
",",
"three",
"human",
"cell",
"lines",
"(",
"U-937",
",",
"THP-1",
",",
"and",
"HL-60",
")",
"were",
"examined",
"for",
":",
"1",
")",
"the",
"presence",
"of",
"functional",
"1",
",",
"25-",
"(",
"OH",
")",
"2D3",
"receptors",
";",
"2",
")",
"the",
"accumulation",
"of",
"interleukin-1",
"beta",
"(",
"IL-1",
"beta",
")",
"mRNA",
"and",
"IL-1",
"beta",
"protein",
"in",
"response",
"to",
"lipopolysaccharide",
"(",
"LPS",
")",
";",
"and",
"3",
")",
"the",
"regulation",
"of",
"this",
"response",
"by",
"1",
",",
"25-",
"(",
"OH",
")",
"2D3",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
5,
0,
5,
0,
0,
5,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
3,
4,
4,
4,
4,
4,
4,
0,
9,
10,
10,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
15993 | [
"All",
"three",
"cell",
"lines",
"expressed",
"vitamin",
"D",
"receptor",
"and",
"had",
"increased",
"levels",
"of",
"IL-1",
"beta",
"mRNA",
"in",
"response",
"to",
"LPS",
"."
] | [
0,
0,
0,
0,
0,
9,
10,
10,
0,
0,
0,
0,
0,
3,
4,
4,
0,
0,
0,
0,
0
] |
15994 | [
"Preincubation",
"of",
"cells",
"with",
"1",
",",
"25-",
"(",
"OH",
")",
"2D3",
"augmented",
"IL-1",
"beta",
"mRNA",
"levels",
"only",
"in",
"U-937",
"and",
"HL-60",
"cells",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
3,
4,
4,
0,
0,
0,
5,
0,
5,
6,
0
] |
15995 | [
"From",
"these",
"data",
",",
"and",
"taking",
"into",
"consideration",
"their",
"state",
"of",
"differentiation",
"and",
"relative",
"ease",
"of",
"culture",
",",
"U-937",
"was",
"chosen",
"over",
"HL-60",
"and",
"THP-1",
"as",
"the",
"cell",
"line",
"we",
"further",
"characterized",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
5,
0,
0,
0,
5,
0,
5,
0,
0,
0,
0,
0,
0,
0,
0
] |
15996 | [
"In",
"U-937",
"cells",
",",
"optimum",
"time",
"and",
"dose",
"of",
"pretreatment",
"with",
"1",
",",
"25-",
"(",
"OH",
")",
"2D3",
"were",
"determined",
"to",
"be",
"12-24",
"h",
"at",
"a",
"receptor",
"saturating",
"concentration",
"of",
"1",
",",
"25-",
"(",
"OH",
")",
"2D3",
"(",
"10",
"nM",
")",
"."
] | [
0,
5,
6,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
15997 | [
"Preincubation",
"of",
"cells",
"with",
"1",
",",
"25-",
"(",
"OH",
")",
"2D3",
"had",
"no",
"effect",
"on",
"the",
"time",
"course",
"of",
"IL-1",
"beta",
"mRNA",
"appearance",
"in",
"response",
"to",
"LPS",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
3,
4,
4,
0,
0,
0,
0,
0,
0
] |
15998 | [
"However",
",",
"exposure",
"of",
"U-937",
"cells",
"to",
"1",
",",
"25-",
"(",
"OH",
")",
"2D3",
"increased",
"by",
"200",
"%",
"the",
"level",
"of",
"IL-1",
"beta",
"mRNA",
"detected",
"and",
"decreased",
"by",
"three",
"orders",
"of",
"magnitude",
"the",
"concentration",
"of",
"LPS",
"required",
"to",
"achieve",
"steady",
"state",
"mRNA",
"levels",
"equivalent",
"to",
"those",
"observed",
"in",
"U-937",
"cells",
"not",
"preincubated",
"with",
"the",
"hormone.2+o"
] | [
0,
0,
0,
0,
5,
6,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
3,
4,
4,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
5,
6,
0,
0,
0,
0,
0
] |
15999 | [
"Regulation",
"of",
"M-CSF",
"expression",
"by",
"M-CSF",
":",
"role",
"of",
"protein",
"kinase",
"C",
"and",
"transcription",
"factor",
"NF",
"kappa",
"B",
"."
] | [
0,
0,
9,
0,
0,
9,
0,
0,
0,
9,
10,
10,
0,
9,
10,
10,
10,
10,
0
] |
16000 | [
"Macrophage-colony-stimulating",
"factor",
"(",
"M-CSF",
")",
",",
"also",
"referred",
"to",
"as",
"CSF-1",
",",
"regulates",
"the",
"survival",
",",
"growth",
",",
"differentiation",
"and",
"functional",
"activity",
"of",
"monocytes",
"by",
"binding",
"to",
"a",
"single",
"class",
"of",
"high-affinity",
"cell",
"surface",
"receptors",
",",
"known",
"to",
"be",
"the",
"product",
"of",
"the",
"c-fms",
"protooncogene",
"."
] | [
9,
10,
0,
9,
0,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
7,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
0
] |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.