Datasets:
siddharthtumre
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Revised-JNLPBA

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16201
[ "The", "finding", "that", "dexamethasone", "has", "no", "effect", "on", "TPA-induced", "activation", "of", "PKC", "suggests", "that", "this", "glucocorticoid", "inhibits", "signals", "downstream", "or", "parallel", "to", "this", "enzyme", "." ]
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16202
[ "Nuclear", "run-on", "assays", "demonstrate", "that", ":", "(", "1", ")", "induction", "of", "c-jun", "and", "c-fos", "expression", "by", "TPA", "is", "regulated", "by", "transcriptional", "mechanisms", ",", "(", "2", ")", "TPA-induced", "expression", "of", "c-jun", "and", "c-fos", "does", "not", "require", "protein", "synthesis", ",", "and", "(", "3", ")", "TPA-induced", "expression", "of", "both", "genes", "is", "inhibited", "at", "the", "transcriptional", "level", "by", "dexamethasone", "." ]
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16203
[ "To", "further", "define", "the", "effects", "of", "dexamethasone", "at", "the", "molecular", "level", ",", "we", "prepared", "a", "series", "of", "deleted", "c-jun", "promoter", "fragments", "linked", "to", "the", "chloramphenicol", "acetyltransferase", "(", "CAT", ")", "gene", "." ]
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16204
[ "Increases", "in", "CAT", "activity", "during", "transient", "expression", "of", "these", "constructs", "in", "TPA-treated", "U-937", "cells", "could", "be", "assigned", "to", "the", "region", "(", "-97", "to", "-20", ")", "of", "the", "promoter", "that", "contains", "the", "AP-1", "binding", "site", "." ]
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16205
[ "This", "induction", "of", "CAT", "activity", "was", "sensitive", "to", "dexamethasone", "." ]
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16206
[ "These", "findings", "suggest", "that", "dexamethasone", "down-regulates", "TPA-induced", "transcription", "of", "the", "c-jun", "gene", "during", "monocytic", "differentiation", "by", "inhibiting", "activation", "of", "the", "AP-1", "site", "." ]
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16207
[ "Tumor", "necrosis", "factor-alpha", "mRNA", "accumulation", "in", "human", "myelomonocytic", "cell", "lines", "." ]
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16208
[ "Role", "of", "transcriptional", "regulation", "by", "DNA", "sequence", "motifs", "and", "mRNA", "stabilization", "." ]
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16209
[ "The", "cytokine", "TNF", "mediates", "many", "of", "the", "pathologic", "signs", "of", "cachexia", ",", "inflammation", ",", "and", "sepsis", "." ]
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16210
[ "The", "current", "work", "describes", "the", "regulation", "of", "TNF", "in", "human", "myelomonocytic", "cell", "lines", "after", "PMA", "stimulation", "." ]
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16211
[ "The", "cell", "lines", "exhibit", "a", "low", "level", "of", "constitutive", "TNF", "mRNA", "expression", "." ]
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16212
[ "Within", "2", "to", "4", "h", "of", "PMA", "exposure", ",", "steady", "state", "levels", "of", "TNF", "mRNA", "are", "markedly", "elevated", "in", "all", "myelomonocytic", "cell", "lines", "studied", "." ]
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16213
[ "This", "rise", "is", "due", "to", "increased", "mRNA", "stability", ",", "which", "increased", "by", "almost", "twofold", ",", "and", "to", "an", "overall", "increase", "in", "transcription", ",", "which", "rises", "by", "more", "than", "sixfold", "." ]
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16214
[ "At", "the", "level", "of", "the", "genomic", "TNF", "gene", ",", "a", "DNase", "I", "hypersensitive", "site", "is", "detected", "within", "the", "TNF", "promoter", "between", "-200", "to", "-100", "bp", "relative", "to", "the", "transcription", "initiation", "site", "." ]
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16215
[ "Although", "absent", "in", "nonexpressing", "erythroleukemia", "cell", "lines", ",", "the", "DNase", "I", "site", "is", "present", "in", "uninduced", "myelomonocytic", "cell", "lines", "and", "is", "not", "changed", "after", "PMA", "induction", "." ]
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16216
[ "The", "PMA", "induction", "of", "c-fos", "mRNA", "correlated", "well", "with", "TNF", "gene", "induction", ";", "expression", "of", "genes", "encoding", "other", "proteins", "in", "the", "AP-1", "complex", "(", "junB", "and", "junD", ")", "were", "also", "induced", "by", "PMA", "." ]
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16217
[ "The", "nuclear", "extracts", "from", "resting", "and", "induced", "ML-1", "cells", "contain", "proteins", "binding", "specifically", "to", "the", "AP-1", ",", "AP-2", ",", "and", "NF", "kappa", "B", "sequence", "located", "within", "the", "TNF", "promoter", "." ]
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16218
[ "PMA", "induction", "increases", "the", "level", "of", "a", "number", "of", "specific", "binding", "complexes", "relative", "to", "the", "resting", "cells", "." ]
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16219
[ "The", "regulatory", "mechanisms", "of", "the", "human", "and", "murine", "TNF", "genes", "are", "discussed", "." ]
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16220
[ "Enhancement", "of", "human", "immunodeficiency", "virus", "1", "replication", "in", "monocytes", "by", "1", ",", "25-dihydroxycholecalciferol", "." ]
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16221
[ "Human", "immunodeficiency", "virus", "(", "HIV", ")", "expression", "and", "replication", "are", "under", "tight", "regulatory", "control", "." ]
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16222
[ "We", "demonstrate", "that", "1", ",", "25-dihydroxycholecalciferol", "[", "1", ",", "25-", "(", "OH", ")", "2D3", "]", "enhances", "the", "replication", "of", "monocyte-", "and", "lymphocyte-tropic", "strains", "of", "HIV-1", "up", "to", "10", ",", "000-fold", "in", "monocyte", "cell", "lines", ",", "peripheral", "blood", "monocytes", ",", "and", "unfractionated", "peripheral", "blood", "mononuclear", "cells", "." ]
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16223
[ "1", ",", "25", "(", "OH", ")", "2D3", "is", "therefore", "one", "of", "the", "most", "potent", "regulators", "of", "HIV-1", "replication", "described", "to", "date", "." ]
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16224
[ "Precursors", "of", "1", ",", "25", "(", "OH", ")", "2D3", "enhance", "HIV-1", "replication", "in", "proportion", "to", "their", "affinity", "for", "the", "1", ",", "25", "(", "OH", ")", "2D3", "intracellular", "receptor", ",", "suggesting", "that", "1", ",", "25", "(", "OH", ")", "2D3", "influences", "HIV-1", "replication", "by", "mechanisms", "involving", "this", "receptor", "." ]
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16225
[ "These", "studies", "may", "have", "important", "implications", "for", "the", "design", "of", "effective", "therapy", "of", "HIV-1", "infection", "." ]
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16226
[ "Transforming", "growth", "factor-beta", "suppresses", "human", "B", "lymphocyte", "Ig", "production", "by", "inhibiting", "synthesis", "and", "the", "switch", "from", "the", "membrane", "form", "to", "the", "secreted", "form", "of", "Ig", "mRNA", "." ]
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16227
[ "Transforming", "growth", "factor-beta", "(", "TGF-beta", ")", "inhibits", "B", "cell", "Ig", "secretion", "and", "reduces", "B", "cell", "membrane", "Ig", "expression", "." ]
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16228
[ "The", "addition", "of", "TGF-beta", "to", "human", "B", "lymphocyte", "cultures", "stimulated", "with", "Staphylococcus", "aureus", "Cowan", "strain", "I", "and", "IL-2", "completely", "inhibited", "B", "cell", "Ig", "secretion", "(", "greater", "than", "90", "%", ")", "and", "decreased", "B", "cell", "surface", "IgM", ",", "IgD", ",", "kappa", "L", "chain", ",", "and", "lambda", "L", "chain", "expression", "." ]
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16229
[ "In", "contrast", ",", "TGF-beta", "had", "only", "minimal", "effects", "on", "two", "other", "B", "cell", "membrane", "proteins", ",", "HLA-DR", "and", "CD20", "." ]
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16230
[ "Internal", "labeling", "with", "[", "35S", "]", "methionine", "and", "immunoprecipitation", "with", "anti-IgM", ",", "anti-kappa", ",", "and", "anti-lambda", "antibodies", "revealed", "a", "striking", "reduction", "in", "kappa", "L", "chain", "in", "the", "presence", "of", "TGF-beta", "." ]
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16231
[ "A", "less", "pronounced", "reduction", "in", "lambda", "L", "chain", "and", "microH", "chain", "was", "also", "noted", "." ]
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16232
[ "Northern", "blot", "analysis", "of", "RNA", "purified", "from", "B", "cells", "treated", "with", "TGF-beta", "for", "varying", "time", "intervals", "revealed", "a", "significant", "decrease", "in", "steady", "state", "kappa", "and", "lambda", "L", "chain", "mRNA", "levels", "." ]
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16233
[ "Furthermore", ",", "a", "significant", "decrease", "in", "the", "switch", "from", "the", "membrane", "forms", "of", "mu", "and", "gamma", "to", "their", "respective", "secreted", "forms", "was", "noted", "in", "the", "presence", "of", "TGF-beta", "." ]
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16234
[ "Nuclear", "run-on", "experiments", "demonstrated", "decreased", "transcription", "of", "kappa", "L", "chain", "." ]
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16235
[ "The", "effects", "of", "TGF-beta", "on", "two", "transcriptional", "regulatory", "factors", ",", "Oct-2", "and", "nuclear", "factor", "(", "NF", ")", "kappa", "B", ",", "known", "to", "be", "important", "in", "Ig", "gene", "transcription", "were", "examined", "." ]
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16236
[ "Oct-2", "mRNA", "levels", "and", "both", "Oct-2", "and", "NF-kappa", "B", "proteins", "in", "nuclear", "extracts", "were", "not", "altered", "by", "treatment", "with", "TGF-beta", "." ]
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16237
[ "In", "contrast", ",", "levels", "of", "the", "transcriptional", "factor", "AP-1", ",", "which", "is", "not", "known", "to", "be", "important", "in", "B", "cell", "Ig", "production", ",", "were", "reduced", "by", "TGF-beta", "." ]
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16238
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16239
[ "The", "mechanism", "by", "which", "TGF-beta", "inhibits", "Ig", "chain", "synthesis", "is", "unclear", "although", "it", "does", "not", "involve", "inhibition", "of", "the", "binding", "of", "NF-kappa", "B", "or", "Oct-2", "to", "their", "respective", "target", "sequences", "." ]
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16240
[ "Murine", "and", "human", "T-lymphocyte", "GATA-3", "factors", "mediate", "transcription", "through", "a", "cis-regulatory", "element", "within", "the", "human", "T-cell", "receptor", "delta", "gene", "enhancer", "." ]
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16241
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16242
[ "One", "of", "the", "members", "of", "this", "multigene", "family", ",", "cGATA-3", ",", "is", "most", "abundantly", "expressed", "in", "the", "T-lymphocyte", "cell", "lineage", "." ]
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16243
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16244
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16245
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16246
[ "Processing", "of", "the", "precursor", "of", "NF-kappa", "B", "by", "the", "HIV-1", "protease", "during", "acute", "infection", "." ]
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16247
[ "Transcription", "of", "the", "human", "immunodeficiency", "virus", "type-1", "(", "HIV-1", ")", "genome", "is", "regulated", "in", "part", "by", "cellular", "factors", "and", "is", "stimulated", "by", "activation", "of", "latently", "infected", "T", "cells", "." ]
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16248
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16249
[ "This", "factor", "consists", "of", "two", "DNA-binding", "subunits", "of", "relative", "molecular", "mass", "50", ",", "000", "(", "50K", ")", "associated", "with", "two", "65K", "subunits", "." ]
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16250
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16251
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16252
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16253
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16254
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16255
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16256
[ "1", ",", "25-Dihydroxyvitamin", "D3", "receptor", "RNA", ":", "expression", "in", "hematopoietic", "cells", "." ]
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