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16401
[ "The", "C26", "element", "conferred", "partial", "responsiveness", "to", "p40tax", "when", "linked", "to", "one", "copy", "of", "the", "21-bp", "element", "that", ",", "by", "itself", ",", "showed", "little", "activation", "in", "response", "to", "p40tax", "." ]
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16402
[ "However", ",", "the", "C26", "element", "alone", ",", "even", "when", "repeated", ",", "could", "not", "be", "activated", "by", "p40tax", ",", "unlike", "other", "NF-kappa", "B-binding", "elements", "." ]
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16403
[ "In", "contrast", ",", "the", "C26", "element", "itself", "was", "profoundly", "activated", "upon", "stimulation", "with", "12-O-tetradecanoylphorbol-13-acetate", "." ]
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16404
[ "These", "findings", "therefore", "suggest", "that", "the", "HTLV-I", "enhancer", "contains", "multiple", "functional", "elements", ",", "including", "binding", "sites", "for", "at", "least", "CREB-", "and", "NF-kappa", "B-like", "factors", ",", "which", "synergistically", "cooperate", "in", "activation", "of", "the", "HTLV-I", "enhancer", "in", "response", "to", "p40tax", "." ]
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16405
[ "Our", "results", "also", "demonstrate", "that", "TPA-dependent", "activation", "of", "the", "HTLV-I", "enhancer", "may", "be", "mediated", "through", "the", "C26", "element", "." ]
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16406
[ "Human", "tumor", "necrosis", "factor", "alpha", "gene", "regulation", "in", "phorbol", "ester", "stimulated", "T", "and", "B", "cell", "lines", "." ]
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16407
[ "The", "minimal", "region", "of", "the", "human", "tumor", "necrosis", "factor", "alpha", "(", "TNF-alpha", ")", "gene", "promoter", "necessary", "for", "its", "transcriptional", "induction", "by", "phorbol", "esters", "(", "PMA", ")", "in", "human", "T", "and", "B", "lymphocyte", "cell", "lines", "has", "been", "localized", "between", "-52", "and", "+89", "nucleotides", "(", "nt", ")", "relative", "to", "the", "gene", "'s", "transcriptional", "start", "site", "." ]
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16408
[ "Comparison", "of", "these", "sequences", "to", "those", "required", "to", "mediate", "virus", "or", "lipopolysaccharide", "(", "LPS", ")", "induction", "of", "the", "gene", "reveal", "significant", "differences", ",", "and", "thus", ",", "the", "sequence", "requirements", "for", "PMA", "induction", "are", "distinct", "from", "those", "that", "mediate", "induction", "by", "virus", "or", "LPS", "." ]
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16409
[ "Although", "three", "sites", "in", "the", "TNF-alpha", "promoter", "(", "kappa", "1", ",", "kappa", "2", ",", "and", "kappa", "3", ")", "specifically", "bind", "the", "transcription", "factor", "NF-kappa", "B", "in", "lymphoid", "nuclear", "extracts", ",", "TNF-alpha", "mRNA", "induction", "by", "PMA", "does", "not", "correlate", "with", "NF-kappa", "B", "binding", "activities", "displayed", "by", "different", "T", "and", "B", "cell", "lines", "." ]
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16410
[ "Moreover", ",", "kappa", "1-kappa", "3", "can", "each", "be", "deleted", "from", "the", "TNF-alpha", "promoter", "with", "little", "effect", "on", "the", "gene", "'s", "inducibility", "by", "PMA", "." ]
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16411
[ "Therefore", ",", "TNF-alpha", "mRNA", "induction", "by", "PMA", ",", "like", "its", "induction", "by", "virus", "and", "LPS", ",", "is", "not", "primarily", "mediated", "by", "NF-kappa", "B", ",", "but", "rather", "is", "mediated", "through", "other", "sequences", "and", "protein", "factors", "." ]
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16412
[ "Surprisingly", ",", "multimers", "of", "kappa", "1-kappa", "3", "can", "confer", "PMA", "inducibility", "on", "a", "heterologous", "promoter", "in", "a", "B", "(", "Raji", ")", ",", "but", "not", "a", "T", "(", "HUT78", ")", "cell", "line", "." ]
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16413
[ "However", "they", "are", "not", "functional", "on", "a", "truncated", "TNF-alpha", "promoter", ",", "indicating", "that", "promoter", "context", "and", "cell", "type", "specificity", "influence", "the", "PMA", "inducible", "function", "of", "these", "NF-kappa", "B", "binding", "sites", "." ]
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16414
[ "Differentiation-associated", "expression", "of", "the", "Epstein-Barr", "virus", "BZLF1", "transactivator", "protein", "in", "oral", "hairy", "leukoplakia", "." ]
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16415
[ "The", "BZLF1", "protein", "of", "Epstein-Barr", "virus", "(", "EBV", ")", "is", "a", "key", "immediate-early", "protein", "which", "has", "been", "shown", "to", "disrupt", "virus", "latency", "in", "EBV-infected", "B", "cells", "." ]
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16416
[ "We", "have", "generated", "a", "monoclonal", "antibody", ",", "BZ1", ",", "to", "BZLF1", "which", "reacts", "in", "immunohistology", ",", "immunoblotting", ",", "and", "immunoprecipitation", "and", "which", "recognizes", "both", "the", "active", ",", "dimeric", "form", "and", "the", "inactive", ",", "monomeric", "form", "of", "the", "protein", "." ]
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16417
[ "Biopsies", "of", "oral", "hairy", "leukoplakia", ",", "an", "AIDS-associated", "lesion", "characterized", "by", "high-level", "EBV", "replication", ",", "were", "examined", "by", "immunohistochemistry", "using", "the", "BZ1", "monoclonal", "antibody", "." ]
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16418
[ "A", "differentiation-associated", "pattern", "of", "BZLF1", "expression", "was", "observed", ",", "BZ1", "reacting", "with", "nuclei", "of", "the", "upper", "spinous", "layer", "of", "the", "lesion", "." ]
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16419
[ "This", "finding", "suggests", "that", "the", "BZLF1", "promoter", "may", "be", "regulated", "by", "the", "degree", "of", "squamous", "differentiation", "." ]
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16420
[ "A", "comparison", "of", "in", "situ", "hybridization", "to", "EBV", "DNA", "and", "viral", "capsid", "antigen", "staining", "with", "BZ1", "reactivity", "suggested", "that", "BZLF1", "expression", "precedes", "rampant", "virus", "replication", "." ]
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16421
[ "The", "inability", "to", "detect", "EBV", "in", "the", "lower", "epithelial", "layers", "of", "oral", "hairy", "leukoplakia", "raises", "questions", "concerning", "the", "nature", "of", "EBV", "latency", "and", "persistence", "in", "stratified", "squamous", "epithelium", "." ]
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16422
[ "[", "Changes", "in", "levels", "of", "leucocytic", "estrogen", "receptor", "in", "patients", "with", "menopausal", "type", "II", "diabetes", "and", "its", "significance", "]" ]
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16423
[ "The", "number", "of", "estrogen", "receptors", "(", "ER", ")", "in", "human", "peripheral", "leucocytes", "in", "12", "women", "with", "menopausal", "type", "II", "diabetes", "was", "measured", "with", "radio-ligand", "binding", "method", "." ]
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16424
[ "The", "results", "were", "compared", "with", "those", "of", "12", "menopausal", "women", "without", "diabetes", "and", "12", "normal", "women", "of", "childbearing", "age", "." ]
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16425
[ "It", "was", "found", "that", "the", "number", "of", "ER", "in", "the", "patients", "was", "significantly", "decreased", "." ]
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16426
[ "Our", "data", "indicate", "that", "decrease", "of", "ER", "level", "in", "leukocytes", "may", "be", "related", "to", "the", "pathogenesis", "of", "type", "II", "diabetes", "in", "menopausal", "period", "." ]
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16427
[ "Lymphocyte", "glucocorticoid", "receptor", "number", "in", "posttraumatic", "stress", "disorder", "." ]
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16428
[ "OBJECTIVE", ":", "The", "authors", "'", "objective", "was", "to", "investigate", "the", "possibility", "that", "glucocorticoid", "receptor", "changes", "may", "be", "involved", "in", "the", "dysregulation", "of", "the", "hypothalamic-pituitary-adrenal", "(", "HPA", ")", "axis", "in", "posttraumatic", "stress", "disorder", "(", "PTSD", ")", "." ]
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16429
[ "METHOD", ":", "They", "measured", "the", "number", "of", "lymphocyte", "cytosolic", "glucocorticoid", "receptors", "and", "plasma", "cortisol", "concentrations", "in", "15", "consecutively", "admitted", "male", "combat", "Vietnam", "veterans", "with", "PTSD", "and", "in", "a", "normal", "comparison", "group", "of", "11", "subjects", "." ]
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16430
[ "RESULTS", ":", "Both", "the", "patients", "and", "the", "normal", "comparison", "subjects", "showed", "a", "morning-to-afternoon", "decline", "in", "glucocorticoid", "receptor", "concentrations", ",", "paralleling", "the", "normal", "diurnal", "decline", "in", "cortisol", "levels", "." ]
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16431
[ "The", "number", "of", "glucocorticoid", "receptors", "was", "63", "%", "greater", "in", "the", "morning", "and", "26", "%", "greater", "in", "the", "afternoon", "in", "the", "patients", "with", "PTSD", "than", "in", "the", "normal", "subjects", "." ]
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16432
[ "No", "group", "differences", "in", "cortisol", "levels", "were", "observed", ",", "nor", "were", "glucocorticoid", "receptor", "number", "and", "cortisol", "levels", "correlated", "." ]
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16433
[ "The", "number", "of", "morning", "glucocorticoid", "receptors", "was", "positively", "correlated", "with", "symptoms", "of", "PTSD", "and", "anxiety", "." ]
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16434
[ "CONCLUSIONS", ":", "These", "results", "provide", "further", "evidence", "for", "a", "dysregulation", "of", "the", "HPA", "axis", "in", "PTSD", "." ]
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16435
[ "The", "finding", "that", "patients", "with", "PTSD", "had", "a", "substantially", "greater", "number", "of", "lymphocyte", "glucocorticoid", "receptors", "than", "normal", "comparison", "subjects", "is", "consistent", "with", "the", "authors", "'", "previous", "observations", "of", "low", "24-hour", "urinary", "cortisol", "excretion", "in", "subjects", "with", "PTSD", "." ]
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16436
[ "Furthermore", ",", "the", "receptor", "changes", "observed", "are", "opposite", "of", "those", "reported", "in", "major", "depressive", "disorder", "." ]
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16437
[ "The", "present", "data", ",", "along", "with", "other", "findings", "of", "HPA", "abnormalities", "in", "PTSD", ",", "support", "the", "possibility", "of", "a", "greater", "negative", "feedback", "sensitivity", "at", "one", "or", "more", "levels", "of", "the", "HPA", "axis", "." ]
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16438
[ "Induction", "of", "NF-kappa", "B", "during", "monocyte", "differentiation", "is", "associated", "with", "activation", "of", "HIV-gene", "expression", "." ]
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16439
[ "Cells", "of", "the", "monocyte-macrophage", "lineage", "are", "important", "targets", "of", "HIV", "infection", "." ]
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16440
[ "We", "report", "here", "that", "the", "phenotypic", "differentiation", "of", "monocyte", "cell", "lines", "induced", "by", "phorbol", "esters", "or", "tumour", "necrosis", "factor", "alpha", "(", "TNF", "alpha", ")", "is", "associated", "with", "expression", "of", "nuclear", "factor", "kappa", "B", "(", "NF-kappa", "B", ")", "." ]
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16441
[ "In", "parallel", "with", "such", "differentiation", ",", "HIV", "transcription", ",", "monitored", "using", "an", "HIV", "long", "terminal", "repeat", "reporter", "gene", "construct", ",", "is", "activated", "in", "such", "cells", "under", "the", "influence", "of", "enhanced", "NF-kappa", "B", "expression", "." ]
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16442
[ "Also", ",", "in", "a", "promonocyte", "cell", "line", "chronically", "infected", "with", "HIV", ",", "NF-kappa", "B", "expression", "and", "HIV", "transcription", "were", "enhanced", "on", "stimulation", "with", "phorbol", "ester", "or", "TNF", "alpha", "." ]
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16443
[ "Thus", ",", "stimulation", "of", "monocyte", "cell", "lines", "by", "phorbol", "esters", "or", "TNF", "alpha", "induces", "cell", "differentiation", "and", "activates", "HIV", "transcription", "." ]
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16444
[ "Such", "a", "process", "may", "have", "fundamental", "implications", "in", "AIDS", "pathogenesis", "in", "vivo", "and", "may", "be", "important", "in", "disease", "progression", "induced", "by", "opportunistic", "infections", "directly", "or", "indirectly", "involving", "macrophages", "." ]
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16445
[ "Demonstration", "of", "estrogen", "and", "progesterone", "receptors", "as", "well", "as", "Ki-67", "and", "p-145", "antigens", "in", "single", "tumor", "cells", "from", "blood", "and", "pleural", "effusions", "using", "a", "slide", "assay", "." ]
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16446
[ "We", "describe", "a", "slide", "assay", "that", "allows", "the", "demonstration", "of", "antigens", "localized", "in", "the", "nucleus", "from", "isolated", "white", "blood", "cells", "as", "well", "as", "from", "single", "tumor", "cells", "derived", "from", "malignant", "effusions", "." ]
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16447
[ "With", "the", "antibodies", "Ki-67", "and", "anti-p-145", "an", "increased", "rate", "of", "nuclear", "and", "nucleolar", "staining", "resulted", "in", "cells", "from", "highly", "malignant", "lymphomas", "." ]
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16448
[ "An", "almost", "identical", "reaction", "was", "obtained", "when", "tumor", "cells", "from", "malignant", "effusions", "were", "tested", "." ]
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16449
[ "Cells", "isolated", "from", "the", "blood", "of", "patients", "with", "leukemic", "spread", "of", "lymphomas", "of", "low", "malignancy", "yielded", "a", "weak", "staining", "comparable", "to", "that", "of", "normal", "mesothelial", "cells", "from", "non-tumorous", "cavity", "fluids", "." ]
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16450
[ "The", "detection", "of", "estrogen", "and", "progesterone", "receptors", "(", "ER", "and", "PR", ")", "localized", "in", "the", "cell", "nucleus", "can", "be", "achieved", "by", "the", "same", "assay", "." ]
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16451
[ "The", "reaction", "is", "enhanced", "by", "incubation", "of", "the", "tumor", "cells", "for", "30", "min", "at", "37", "degrees", "C", "prior", "to", "fixation", "." ]
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16452
[ "Pleural", "effusions", "from", "20", "patients", "with", "breast", "cancer", "were", "tested", "." ]
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16453
[ "ER", "was", "positive", "in", "13", "and", "PR", "was", "positive", "in", "12", "of", "the", "20", "samples", "." ]
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16454
[ "In", "5", "cases", "there", "was", "a", "divergent", "reaction", "with", "ER", "and", "PR", "antibody", "." ]
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16455
[ "The", "hormone", "receptors", "of", "the", "primary", "tumor", "were", "known", "in", "15", "(", "ER", ")", "and", "14", "(", "PR", ")", "patients", ",", "respectively", "." ]
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16456
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