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15201
[ "Here", "we", "demonstrate", "that", "the", "c-myb", "proto-oncogene", "product", ",", "which", "is", "itself", "a", "DNA-binding", "protein", "and", "transcriptional", "transactivator", ",", "can", "interact", "synergistically", "with", "Z", "in", "activating", "the", "BMRF1", "promoter", "in", "Jurkat", "cells", "(", "a", "T-cell", "line", ")", "or", "Raji", "cells", "(", "an", "EBV-positive", "B-cell", ")", ",", "whereas", "the", "c-myb", "gene", "product", "by", "itself", "has", "little", "effect", "." ]
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15202
[ "The", "simian", "virus", "40", "early", "promoter", "is", "also", "synergistically", "activated", "by", "the", "Z/c-myb", "combination", "." ]
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15203
[ "Synergistic", "transactivation", "of", "the", "BMRF1", "promoter", "by", "the", "Z/c-myb", "combination", "appears", "to", "involve", "direct", "binding", "by", "the", "Z", "protein", "but", "not", "the", "c-myb", "protein", "." ]
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15204
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15205
[ "That", "the", "c-myb", "oncogene", "product", "can", "interact", "synergistically", "with", "an", "EBV-encoded", "member", "of", "the", "leucine", "zipper", "protein", "family", "suggests", "c-myb", "is", "likely", "to", "engage", "in", "similar", "interactions", "with", "cellularly", "encoded", "transcription", "factors", "." ]
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15206
[ "Alpha-lipoic", "acid", "is", "a", "potent", "inhibitor", "of", "NF-kappa", "B", "activation", "in", "human", "T", "cells", "." ]
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15207
[ "Acquired", "immunodeficiency", "syndrome", "(", "AIDS", ")", "results", "from", "infection", "with", "a", "human", "immunodeficiency", "virus", "(", "HIV", ")", "." ]
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15208
[ "The", "long", "terminal", "repeat", "(", "LTR", ")", "region", "of", "HIV", "proviral", "DNA", "contains", "binding", "sites", "for", "nuclear", "factor", "kappa", "B", "(", "NF-kappa", "B", ")", ",", "and", "this", "transcriptional", "activator", "appears", "to", "regulate", "HIV", "activation", "." ]
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15209
[ "Recent", "findings", "suggest", "an", "involvement", "of", "reactive", "oxygen", "species", "(", "ROS", ")", "in", "signal", "transduction", "pathways", "leading", "to", "NF-kappa", "B", "activation", "." ]
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15210
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15211
[ "Incubation", "of", "Jurkat", "T", "cells", "(", "1", "x", "10", "(", "6", ")", "cells/ml", ")", "with", "a", "natural", "thiol", "antioxidant", ",", "alpha-lipoic", "acid", ",", "prior", "to", "the", "stimulation", "of", "cells", "was", "found", "to", "inhibit", "NF-kappa", "B", "activation", "induced", "by", "tumor", "necrosis", "factor-alpha", "(", "25", "ng/ml", ")", "or", "by", "phorbol", "12-myristate", "13-acetate", "(", "50", "ng/ml", ")", "." ]
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15212
[ "The", "inhibitory", "action", "of", "alpha-lipoic", "acid", "was", "found", "to", "be", "very", "potent", "as", "only", "4", "mM", "was", "needed", "for", "a", "complete", "inhibition", ",", "whereas", "20", "mM", "was", "required", "for", "N-acetylcysteine", "." ]
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15213
[ "These", "results", "indicate", "that", "alpha-lipoic", "acid", "may", "be", "effective", "in", "AIDS", "therapeutics", "." ]
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15214
[ "Reticuloendotheliosis", "virus", "long", "terminal", "repeat", "elements", "are", "efficient", "promoters", "in", "cells", "of", "various", "species", "and", "tissue", "origin", ",", "including", "human", "lymphoid", "cells", "." ]
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15215
[ "Promiscuous", "transcriptional", "activity", "of", "the", "reticuloendotheliosis", "virus", "(", "REV", ")", "long", "terminal", "repeat", "(", "LTR", ")", "was", "detected", "in", "transient", "expression", "assays", "using", "LTR-chloramphenicol", "acetyltransferase-encoding", "gene", "chimeras", ",", "and", "cells", "of", "diverse", "species", "and", "tissue", "type", ";", "levels", "of", "expression", "from", "two", "different", "REV", "LTRs", "correlate", "with", "reports", "of", "pathogenicity", "of", "the", "respective", "viruses", "in", "vivo", "." ]
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15216
[ "REVs", "do", "not", "encode", "a", "transactivator", "targeted", "to", "the", "viral", "LTR", ",", "and", "cells", "infected", "with", "Marek", "'s", "disease", "virus", ",", "a", "herpesvirus", "with", "an", "overlapping", "host", "range", ",", "do", "not", "express", "factors", "that", "preferentially", "enhance", "expression", "from", "REV", "or", "avian", "sarcoma/leukemia", "virus", "LTRs", "." ]
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15217
[ "REV", "LTRs", "work", "efficiently", "in", "human", "lymphoid", "cells", ",", "and", "are", "viable", "alternatives", "to", "promoters", "commonly", "used", "for", "expression", "of", "cloned", "genes", "." ]
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15218
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15219
[ "A", "novel", "Ets-related", "transcription", "factor", ",", "Elf-1", ",", "binds", "to", "human", "immunodeficiency", "virus", "type", "2", "regulatory", "elements", "that", "are", "required", "for", "inducible", "trans", "activation", "in", "T", "cells", "." ]
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15220
[ "Human", "immunodeficiency", "virus", "type", "1", "(", "HIV-1", ")", "and", "HIV-2", "are", "structurally", "related", "retroviruses", "which", "both", "cause", "AIDS", "in", "humans", "." ]
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15221
[ "Although", "both", "viruses", "establish", "latency", "in", "quiescent", "human-peripheral-blood", "T", "cells", ",", "the", "asymptomatic", "phase", "of", "HIV-2", "infection", "may", "be", "more", "prolonged", "than", "that", "of", "HIV-1", "." ]
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15222
[ "The", "latent", "phases", "of", "both", "HIV-1", "and", "HIV-2", "infection", "have", "been", "shown", "to", "be", "disrupted", "by", "T-cell", "activation", ",", "a", "process", "that", "requires", "host", "cell", "transcription", "factors", "." ]
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15223
[ "In", "the", "case", "of", "HIV-1", ",", "the", "transcription", "factor", "NF-kappa", "B", "is", "sufficient", "for", "inducible", "transcriptional", "activation", "." ]
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15224
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15225
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15226
[ "Mutagenesis", "experiments", "demonstrated", "that", "these", "Elf-1", "binding", "sites", "are", "required", "for", "induction", "of", "HIV-2", "transcription", "following", "T-cell-receptor-mediated", "T-cell", "activation", "." ]
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15227
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15228
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15229
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15230
[ "Okadaic", "acid", "is", "a", "potent", "inducer", "of", "AP-1", ",", "NF-kappa", "B", ",", "and", "tumor", "necrosis", "factor-alpha", "in", "human", "B", "lymphocytes", "." ]
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15231
[ "Treatment", "of", "human", "B", "lymphocytes", "with", "an", "optimal", "concentration", "of", "okadaic", "acid", ",", "an", "inhibitor", "of", "phosphatases", "1", "and", "2A", ",", "resulted", "in", "the", "induction", "of", "the", "transcription", "factor", ",", "AP-1", "and", "a", "marked", "increase", "in", "NF-kappa", "B", "levels", "." ]
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15232
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15233
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15234
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15235
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15236
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15237
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15238
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15239
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15240
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15241
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15242
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15243
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15244
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15245
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15246
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15247
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15248
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15249
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15250
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15251
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15260
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15262
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15263
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15264
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15265
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15267
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15270
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15272
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15277
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15278
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15279
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15281
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15282
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15283
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15288
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15292
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