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15001
[ "Further", "studies", "will", "have", "to", "prove", "if", "Urapidil", "is", "suited", "for", "prepartal", "treatment", "of", "PIH", "as", "well", "." ]
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15002
[ "Suppression", "of", "a", "cellular", "differentiation", "program", "by", "phorbol", "esters", "coincides", "with", "inhibition", "of", "binding", "of", "a", "cell-specific", "transcription", "factor", "(", "NF-E2", ")", "to", "an", "enhancer", "element", "required", "for", "expression", "of", "an", "erythroid-specific", "gene", "." ]
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15003
[ "Induction", "by", "hemin", "increases", ",", "while", "induction", "with", "12-O-tetradecanoylphorbol-13-acetate", "(", "TPA", ")", "represses", ",", "erythroid-specific", "gene", "expression", "in", "the", "human", "cell", "line", "K562", "." ]
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15004
[ "We", "analyzed", "the", "effects", "of", "hemin", "or", "TPA", "induction", "on", "the", "binding", "and", "activity", "of", "transcription", "factors", "at", "a", "regulatory", "element", "found", "within", "the", "transcriptional", "regulatory", "sequences", "of", "many", "erythroid-specific", "genes", "." ]
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15005
[ "TPA", "induction", "increases", "the", "binding", "of", "ubiquitous", "AP-1", "factors", "to", "this", "element", "." ]
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15006
[ "TPA", "induction", "inhibits", "the", "binding", "of", "the", "lineage", "limited", "transcription", "factor", "NF-E2", "to", "this", "transcriptional", "control", "element", "." ]
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15007
[ "Hemin", "induction", "of", "K562", "cells", "does", "not", "facilitate", "the", "binding", "of", "NF-E2", "to", "its", "recognition", "site", "." ]
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15008
[ "Hemin", "induction", "appears", "to", "nonspecifically", "increase", "the", "expression", "of", "transiently", "transfected", "genes", "in", "K562", "cells", "." ]
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15009
[ "Beyond", "this", "nonspecific", "increase", "in", "gene", "expression", ",", "hemin", "induction", "acts", "to", "increase", "the", "activity", "of", "the", "lineage", "limited", "transcription", "factor", "NF-E2", "." ]
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15010
[ "The", "divergent", "effects", "of", "hemin", "and", "TPA", "on", "gene", "expression", "in", "K562", "cells", "are", "mediated", ",", "in", "part", ",", "by", "their", "contrasting", "effects", "on", "the", "transcription", "factor", "NF-E2", "." ]
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15011
[ "Interleukin-3", "expression", "by", "activated", "T", "cells", "involves", "an", "inducible", ",", "T-cell-specific", "factor", "and", "an", "octamer", "binding", "protein", "." ]
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15012
[ "Interleukin-3", "(", "IL-3", ")", "is", "exclusively", "expressed", "by", "activated", "T", "and", "natural", "killer", "cells", ",", "a", "function", "that", "is", "tightly", "controlled", "both", "in", "a", "lineage-specific", "and", "in", "a", "stimulation-dependent", "manner", "." ]
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15013
[ "We", "have", "investigated", "the", "protein", "binding", "characteristics", "and", "functional", "importance", "of", "the", "ACT-1-activating", "region", "of", "the", "IL-3", "promoter", "." ]
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15014
[ "This", "region", "binds", "an", "inducible", ",", "T-cell-specific", "factor", "over", "its", "5", "'", "end", ",", "a", "site", "that", "is", "necessary", "for", "the", "expression", "of", "IL-3", "in", "the", "absence", "of", "other", "upstream", "elements", "." ]
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15015
[ "Over", "its", "3", "'", "end", ",", "it", "binds", "a", "factor", "that", "is", "ubiquitously", "and", "constitutively", "expressed", "." ]
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15016
[ "This", "factor", "is", "Oct-1", "or", "an", "immunologically", "related", "octamer-binding", "protein", ",", "and", "it", "plays", "a", "role", "in", "coordinating", "the", "activity", "of", "several", "regulatory", "elements", "." ]
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15017
[ "These", "characteristics", "make", "the", "ACT-1", "site", "analogous", "to", "the", "activating", "ARRE-1", "site", "in", "the", "IL-2", "promoter", "." ]
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15018
[ "Furthermore", ",", "and", "despite", "a", "lack", "of", "sequence", "homology", ",", "the", "promoters", "of", "IL-3", "and", "IL-2", "share", "an", "organizational", "pattern", "of", "regulatory", "elements", "that", "is", "likely", "to", "be", "important", "for", "the", "T-cell-specific", "expression", "of", "these", "genes", "." ]
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15019
[ "Interleukin-4", "inhibits", "the", "lipopolysaccharide-induced", "expression", "of", "c-jun", "and", "c-fos", "messenger", "RNA", "and", "activator", "protein-1", "binding", "activity", "in", "human", "monocytes", "." ]
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15020
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15021
[ "These", "genes", "encode", "proteins", "that", "form", "the", "dimeric", "complex", "activator", "protein-1", "(", "AP-1", ")", ",", "which", "is", "active", "as", "a", "transcriptional", "factor", "." ]
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15022
[ "Maximal", "accumulation", "of", "either", "c-fos", "and", "c-jun", "messenger", "RNA", "(", "mRNA", ")", "occurred", "30", "minutes", "after", "LPS", "addition", "." ]
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15023
[ "When", "cells", "were", "treated", "with", "IL-4", "for", "5", "hours", "before", "LPS", "activation", ",", "both", "the", "c-fos", "and", "the", "c-jun", "mRNA", "expression", "was", "decreased", "." ]
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15024
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15025
[ "IL-4", "did", "not", "affect", "the", "stability", "of", "the", "c-fos", "and", "c-jun", "transcripts", "." ]
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15026
[ "Finally", ",", "using", "electrophoretic", "mobility", "shift", "assays", ",", "evidence", "was", "obtained", "that", "IL-4", "inhibits", "LPS-induced", "expression", "of", "AP-1", "protein", "." ]
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15027
[ "These", "data", "indicate", "that", "IL-4", "suppresses", "the", "induction", "of", "transcription", "factors", "in", "human", "activated", "monocytes", "." ]
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15028
[ "Transient", "pseudohypoaldosteronism", "in", "obstructive", "renal", "disease", "with", "transient", "reduction", "of", "lymphocytic", "aldosterone", "receptors", "." ]
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15029
[ "Results", "in", "two", "affected", "infants", "." ]
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15030
[ "We", "report", "two", "patients", "with", "transient", "pseudohypoaldosteronism", "due", "to", "obstructive", "renal", "disease", "." ]
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15031
[ "Both", "patients", "presented", "with", "a", "salt-losing", "episode", "simulating", "adrenal", "insufficiency", "." ]
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15032
[ "In", "one", "patient", ",", "transient", "reduction", "of", "aldosterone", "receptors", "could", "be", "documented", ",", "while", "in", "the", "second", "patient", "the", "clinical", "and", "biochemical", "parameters", "were", "consistent", "with", "transient", "pseudohypoaldosteronism", "." ]
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15033
[ "Aldosterone", "receptors", "were", "normal", "in", "both", "patients" ]
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15034
[ "Aldosterone-specific", "membrane", "receptors", "and", "rapid", "non-genomic", "actions", "of", "mineralocorticoids", "." ]
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15035
[ "Functional", "studies", "in", "extrarenal", ",", "non-epithelial", "cells", "such", "as", "smooth", "muscle", "cells", "and", "more", "recently", "circulating", "human", "lymphocytes", "have", "provided", "increasing", "evidence", "that", "aldosterone", "produces", "not", "only", "classical", "genomic", "effects", ",", "but", "also", "rapid", ",", "non-genomic", "effects", "on", "transmembrane", "electrolyte", "movements", "." ]
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15036
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15037
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15038
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15039
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15040
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15041
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15042
[ "Human", "immunodeficiency", "virus", "type", "1", "(", "HIV-1", ")", "can", "establish", "a", "persistent", "and", "latent", "infection", "in", "CD4+", "T", "lymphocytes", "(", "W.C.Greene", ",", "N.Engl.J.", "Med.324", ":", "308-317", ",", "1991", ";", "S.M.Schnittman", ",", "M.C.Psallidopoulos", ",", "H.C.", "Lane", ",", "L.Thompson", ",", "M.Baseler", ",", "F.Massari", ",", "C.H.Fox", ",", "N.P.Salzman", ",", "and", "A.S.Fauci", ",", "Science", "245", ":", "305-308", ",", "1989", ")", "." ]
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15043
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15044
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15045
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15046
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15047
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15048
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15049
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15050
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15051
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15052
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15053
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15054
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15055
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15056
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15057
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