Datasets:
siddharthtumre
/
Revised-JNLPBA

Dataset card Data Studio Files Community
1
id
stringlengths
1
5
tokens
sequence
ner_tags
sequence
15101
[ "The", "11", "beta-methyl", "analog", "had", "a", "greater", "than", "10-fold", "lower", "activity", "." ]
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15102
[ "The", "differentiating", "effects", "of", "the", "other", "C-11", "analogs", "on", "human", "promyeloid", "leukemia", "cells", "(", "HL-60", ")", "agreed", "well", "with", "their", "bone-resorbing", "activity", "and", "receptor", "affinity", ",", "but", "they", "demonstrated", "lower", "calcemic", "effects", "in", "vivo", "." ]
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15103
[ "Large", "or", "polar", "substitutions", "on", "C-11", "of", "1", "alpha", ",", "25-", "(", "OH", ")", "2D3", "thus", "impair", "the", "binding", "of", "the", "vitamin", "D", "receptor", "but", "increase", "the", "affinity", "to", "vitamin", "D-binding", "protein", "." ]
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15104
[ "The", "effects", "of", "many", "C-11-substituted", "1", "alpha", ",", "25-", "(", "OH", ")", "2D3", "analogs", "on", "HL-60", "cell", "differentiation", "exceeded", "their", "activity", "on", "calcium", "metabolism", "." ]
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15105
[ "Glucocorticoid", "receptor", "binding", "in", "three", "different", "cell", "types", "in", "major", "depressive", "disorder", ":", "lack", "of", "evidence", "of", "receptor", "binding", "defect", "." ]
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15106
[ "1", "." ]
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15107
[ "In", "order", "to", "further", "understand", "the", "apparent", "glucocorticoid", "resistance", "in", "major", "depressive", "disorder", ",", "circadian", "variation", "in", "cortisol", "concentration", ",", "dexamethasone", "suppression", "and", "glucocorticoid", "receptor", "binding", "in", "mononuclear", "leukocytes", ",", "polymorphonuclear", "leukocytes", "and", "cultured", "skin", "fibroblasts", "were", "measured", "in", "rigidly", "defined", "major", "depressive", "disorder", "patients", "and", "non-depressed", "psychiatric", "controls", "." ]
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15108
[ "2", "." ]
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15109
[ "Mononuclear", "leukocytes", "binding", "to", "glucocorticoid", "correlated", "significantly", "with", "polymorphonuclear", "leukocytes", "binding", "to", "glucocorticoid", ",", "but", "both", "determinations", "failed", "to", "differentiate", "major", "depressive", "disorder", "and", "control", "subjects", "." ]
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15110
[ "3", "." ]
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15111
[ "Initial", "and", "post-dexamethasone", "in", "vitro", "fibroblast", "binding", "to", "glucocorticoid", "was", "not", "different", "between", "major", "depressive", "disorder", "and", "non-depressed", "control", "subjects", "." ]
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15112
[ "4", "." ]
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15113
[ "The", "phenomenon", "of", "glucocorticoid", "resistance", "in", "major", "depressive", "disorder", "remains", "unexplained", "." ]
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15114
[ "High", "affinity", "aldosterone", "binding", "to", "plasma", "membrane", "rich", "fractions", "from", "mononuclear", "leukocytes", ":", "is", "there", "a", "membrane", "receptor", "for", "mineralocorticoids", "?" ]
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15115
[ "In", "vitro", "effects", "of", "aldosterone", "on", "the", "intracellular", "concentrations", "of", "sodium", ",", "potassium", "and", "calcium", ",", "cell", "volume", "and", "the", "sodium-proton-antiport", "have", "been", "described", "in", "intact", "human", "mononuclear", "leukocytes", "(", "HML", ")", "." ]
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15116
[ "In", "the", "present", "paper", ",", "the", "binding", "of", "a", "[", "125I", "]", "-labeled", "aldosterone", "derivative", "to", "plasma", "membrane", "rich", "fractions", "of", "HML", "was", "studied", "." ]
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15117
[ "High", "affinity", "binding", "of", "the", "radioligand", "with", "an", "apparent", "Kd", "of", "approximately", "0.1", "nM", "was", "found", "." ]
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15118
[ "Aldosterone", "displaced", "the", "tracer", "at", "a", "similar", "Kd", "." ]
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15119
[ "Both", "canrenone", "and", "cortisol", "were", "inactive", "as", "ligands", "up", "to", "concentrations", "of", "0.1", "microM", "." ]
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15120
[ "The", "findings", "are", "the", "first", "to", "demonstrate", "membrane", "binding", "sites", "with", "a", "high", "affinity", "for", "aldosterone", ",", "but", "not", "for", "cortisol", "." ]
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15121
[ "These", "data", "are", "perfectly", "compatible", "with", "major", "properties", "of", "steroidal", "effects", "on", "the", "sodium-proton-antiport", "in", "HML", "and", "thus", "very", "likely", "represent", "membrane", "receptors", "for", "aldosterone", "." ]
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15122
[ "Natural", "variants", "of", "the", "HIV-1", "long", "terminal", "repeat", ":", "analysis", "of", "promoters", "with", "duplicated", "DNA", "regulatory", "motifs", "." ]
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15123
[ "Sequence", "variation", "in", "the", "long", "terminal", "repeat", "(", "LTR", ")", "region", "of", "HIV-1", "was", "analyzed", "in", "viral", "isolates", "of", "17", "infected", "individuals", "." ]
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15124
[ "Two", "classes", "of", "LTR", "size", "variants", "were", "found", "." ]
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15125
[ "One", "HIV-1", "variant", "was", "detected", "containing", "an", "additional", "binding", "site", "for", "the", "transcription", "factor", "Sp1", "." ]
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15126
[ "Another", "LTR", "size", "variation", "was", "observed", "in", "four", "patients", "in", "a", "region", "just", "upstream", "of", "the", "NF-kappa", "B", "enhancer", "." ]
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15127
[ "This", "variation", "was", "the", "result", "of", "a", "duplication", "of", "a", "short", "DNA", "sequence", "(", "CTG-motif", ")", "." ]
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15128
[ "Cell", "culture", "experiments", "demonstrated", "that", "the", "natural", "variant", "with", "four", "Sp1", "sites", "had", "a", "slightly", "higher", "promoter", "activity", "and", "viral", "replication", "rate", "than", "the", "isogenic", "control", "LTR", "with", "three", "Sp1", "sites", "." ]
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15129
[ "No", "positive", "effect", "of", "the", "duplicated", "CTG-motif", "could", "be", "detected", "." ]
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15130
[ "In", "order", "to", "measure", "small", "differences", "in", "virus", "production", "more", "accurately", ",", "equal", "amounts", "of", "a", "size", "variant", "and", "the", "wild-type", "plasmid", "were", "cotransfected", "into", "T-cells", "." ]
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15131
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15132
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15133
[ "A", "novel", "B", "cell-derived", "coactivator", "potentiates", "the", "activation", "of", "immunoglobulin", "promoters", "by", "octamer-binding", "transcription", "factors", "." ]
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15134
[ "A", "novel", "B", "cell-restricted", "activity", ",", "required", "for", "high", "levels", "of", "octamer", "/", "Oct", "-dependent", "transcription", "from", "an", "immunoglobulin", "heavy", "chain", "(", "IgH", ")", "promoter", ",", "was", "detected", "in", "an", "in", "vitro", "system", "consisting", "of", "HeLa", "cell", "-derived", "extracts", "complemented", "with", "fractionated", "B", "cell", "nuclear", "proteins", "." ]
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15135
[ "The", "factor", "responsible", "for", "this", "activity", "was", "designated", "Oct", "coactivator", "from", "B", "cells", "(", "OCA-B", ")", "." ]
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15136
[ "OCA-B", "stimulates", "the", "transcription", "from", "an", "IgH", "promoter", "in", "conjunction", "with", "either", "Oct-1", "or", "Oct-2", "but", "shows", "no", "significant", "effect", "on", "the", "octamer", "/", "Oct", "-dependent", "transcription", "of", "the", "ubiquitously", "expressed", "histone", "H2B", "promoter", "and", "the", "transcription", "of", "USF-", "and", "Sp1-regulated", "promoters", "." ]
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15137
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15138
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15139
[ "SCL", "and", "related", "hemopoietic", "helix-loop-helix", "transcription", "factors", "." ]
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15140
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15141
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15142
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15143
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15144
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15145
[ "However", ",", "in", "contrast", "to", "GATA-1", ",", "SCL", "is", "expressed", "in", "the", "developing", "brain", "." ]
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15146
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15147
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15148
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15149
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15150
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15151
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15152
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15153
[ "Oct-2", "mRNA", "induction", "during", "antigen-driven", "T-cell", "activation", "was", "blocked", "by", "cyclosporin", "A", ",", "as", "well", "as", "by", "protein", "synthesis", "inhibitors", "." ]
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15154
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15155
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15156
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15157
[ "Glucocorticoid", "receptor", "concentrations", "in", "mononuclear", "leukocytes", "(", "MNL", ")", "in", "these", "patients", "were", "comparable", "with", "those", "in", "both", "other", "patients", "with", "SLE", "and", "healthy", "persons", "." ]
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15158
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15159
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15160
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15161
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15182
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15187
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