Datasets:
siddharthtumre
/
Revised-JNLPBA

Dataset card Data Studio Files Community
1
id
stringlengths
1
5
tokens
sequence
ner_tags
sequence
15301
[ "Alignment", "of", "the", "selected", "sequences", "allowed", "us", "to", "predict", "a", "consensus", "sequence", "for", "binding", "of", "the", "individual", "homodimeric", "Rel-related", "proteins", ",", "and", "DNA-protein", "binding", "analysis", "of", "the", "selected", "DNA", "sequences", "revealed", "sequence", "specificity", "of", "the", "proteins", "." ]
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15302
[ "Contrary", "to", "previous", "assumptions", ",", "we", "observed", "that", "p65", "homodimers", "can", "interact", "with", "a", "subset", "of", "DNA", "sequences", "not", "recognized", "by", "p50", "homodimers", "." ]
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15303
[ "Differential", "binding", "affinities", "were", "also", "obtained", "with", "p50-", "and", "c-Rel-selected", "sequences", "." ]
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15304
[ "Using", "either", "a", "p50-", "or", "p65-", "selected", "kappa", "B", "motif", ",", "which", "displayed", "differential", "binding", "with", "respect", "to", "the", "other", "protein", ",", "little", "to", "no", "binding", "was", "observed", "with", "the", "heterodimeric", "NF-kappa", "B", "complex", "." ]
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15305
[ "Similarly", ",", "in", "transfection", "experiments", "in", "which", "the", "selective", "kappa", "B", "binding", "sites", "were", "used", "to", "drive", "the", "expression", "of", "a", "chloramphenicol", "acetyltransferase", "reporter", "construct", ",", "the", "p65", "-and", "p50-selected", "motifs", "were", "activated", "only", "in", "the", "presence", "of", "p65", "and", "p50/65", "(", "a", "chimeric", "protein", "with", "the", "p50", "DNA", "binding", "domain", "and", "p65", "activation", "domain", ")", "expression", "vectors", ",", "respectively", ",", "and", "neither", "demonstrated", "a", "significant", "response", "to", "stimuli", "that", "induce", "NF-kappa", "B", "activity", "." ]
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15306
[ "These", "findings", "demonstrate", "that", "interaction", "of", "both", "subunits", "of", "the", "heterodimeric", "NF-kappa", "B", "complex", "with", "DNA", "is", "required", "for", "DNA", "binding", "and", "transcriptional", "activation", "and", "suggest", "that", "transcriptional", "activation", "mediated", "by", "the", "individual", "rel-related", "proteins", "will", "differ", "dramatically", ",", "depending", "on", "the", "specific", "kappa", "B", "motifs", "present", "." ]
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15307
[ "NF-kappa", "B", "-dependent", "induction", "of", "the", "NF-kappa", "B", "p50", "subunit", "gene", "promoter", "underlies", "self-perpetuation", "of", "human", "immunodeficiency", "virus", "transcription", "in", "monocytic", "cells", "." ]
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15308
[ "The", "molecular", "mechanisms", "underlying", "the", "sustained", "nuclear", "translocation", "of", "NF-kappa", "B", "observed", "in", "U937", "monocytic", "cells", "chronically", "infected", "with", "human", "immunodeficiency", "virus", "(", "HIV", ")", "were", "studied", "." ]
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15309
[ "The", "activity", "of", "the", "promoter", "regulating", "the", "synthesis", "of", "the", "p105", "precursor", "of", "the", "NF-kappa", "B", "p50", "subunit", "was", "enhanced", "in", "these", "cells", "." ]
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15310
[ "Deletions", "in", "this", "promoter", "indicated", "that", "this", "upregulation", "was", "mediated", "through", "the", "NF-kappa", "B-", "but", "not", "the", "AP-1-binding", "motif", ",", "by", "bona", "fide", "p50/p65", "heterodimers", "." ]
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15311
[ "Analysis", "of", "cytosolic", "extracts", "indicated", "that", "NF-kappa", "B", "levels", "were", "increased", "in", "HIV-infected", "cells", "." ]
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15312
[ "In", "contrast", "to", "the", "transient", "NF-kappa", "B", "activation", "induced", "by", "phorbol", "ester", ",", "the", "permanent", "NF-kappa", "B", "translocation", "induced", "by", "HIV", "infection", "was", "not", "dependent", "on", "PKC", "isoenzymes", "alpha", "and", "beta", "as", "shown", "by", "the", "use", "of", "a", "specific", "inhibitor", "(", "GF", "109203X", ")", "." ]
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15313
[ "These", "observations", "indicate", "that", "during", "chronic", "HIV", "infection", "of", "U937", "cells", ",", "continuous", "NF-kappa", "B", "(", "p50/p65", ")", "translocation", "results", "in", "p105", "promoter", "upregulation", "with", "subsequent", "cytosolic", "NF-kappa", "B", "accumulation", ",", "ready", "for", "further", "translocation", "." ]
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15314
[ "This", "HIV-mediated", "mechanism", "results", "in", "a", "self-perpetuating", "loop", "of", "NF-kappa", "B", "production", "." ]
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15315
[ "Activation", "of", "NF-kappa", "B", "by", "interleukin", "2", "in", "human", "blood", "monocytes", "." ]
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15316
[ "We", "report", "here", "that", "interleukin", "2", "(", "IL-2", ")", "acts", "on", "human", "blood", "monocytes", "by", "enhancing", "binding", "activity", "of", "the", "transcription", "factor", "NF-kappa", "B", "to", "its", "consensus", "sequence", "in", "the", "5", "'", "regulatory", "enhancer", "region", "of", "the", "IL-2", "receptor", "alpha", "chain", "(", "p55", ")", "." ]
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15317
[ "Similarly", ",", "IL-2", "activates", "NF-kappa", "B", "in", "the", "human", "monocytic", "cell", "line", "U", "937", ",", "but", "not", "in", "resting", "human", "T-cells", "." ]
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15318
[ "This", "effect", "is", "detectable", "within", "15", "min", "and", "peaks", "1", "h", "after", "exposure", "to", "IL-2", "." ]
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15319
[ "Enhanced", "NF-kappa", "B", "binding", "activity", "is", "followed", "by", "functional", "activation", "in", "that", "inducibility", "of", "the", "IL-2", "receptor", "alpha", "chain", "is", "mediated", "by", "enhanced", "NF-kappa", "B", "binding", "and", "that", "a", "heterologous", "promoter", "containing", "the", "NF-kappa", "B", "consensus", "sequence", "(", "-291", "to", "-245", ")", "of", "the", "IL-2", "receptor", "alpha", "chain", "gene", "is", "activated", "." ]
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15320
[ "In", "addition", ",", "IL-2", "is", "capable", "of", "increasing", "transcript", "levels", "of", "the", "p50", "gene", "coding", "for", "the", "p50", "subunit", "of", "the", "NF-kappa", "B", "transcription", "factor", ",", "whereas", "mRNA", "levels", "of", "the", "p65", "NF-kappa", "B", "gene", "remained", "unchanged", "." ]
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15321
[ "Studies", "on", "the", "biological", "activity", "of", "triiodothyronine", "sulfate", "." ]
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15322
[ "Hepatic", "microsomes", "and", "isolated", "hepatocytes", "in", "short", "term", "culture", "desulfate", "T3", "sulfate", "(", "T3SO4", ")", "." ]
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15323
[ "We", ",", "therefore", ",", "wished", "to", "determine", "whether", "T3SO4", "could", "mimic", "the", "action", "of", "thyroid", "hormone", "in", "vitro", "." ]
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15324
[ "T3SO4", "had", "no", "thyromimetic", "effect", "on", "the", "activity", "of", "Ca", "(", "2+", ")", "-ATPase", "in", "human", "erythrocyte", "membranes", "at", "doses", "up", "to", "10", ",", "000", "times", "the", "maximally", "effective", "dose", "of", "T3", "(", "10", "(", "-10", ")", "mol/L", ")", "." ]
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15325
[ "In", "GH4C1", "pituitary", "cells", ",", "T3SO4", "failed", "to", "displace", "[", "125I", "]", "T3", "from", "nuclear", "receptors", "in", "intact", "cells", "or", "soluble", "preparations", "." ]
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15326
[ "Thus", ",", "T3SO4", "was", "not", "directly", "thyromimetic", "in", "either", "an", "isolated", "human", "membrane", "system", "or", "a", "pituitary", "cell", "system", "in", "which", "nuclear", "receptor", "occupancy", "correlates", "with", "GH", "synthesis", "." ]
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15327
[ "Thyroid", "hormones", "inhibit", "[", "3H", "]", "glycosaminoglycan", "synthesis", "by", "cultured", "human", "dermal", "fibroblasts", ",", "and", "T3SO4", "displayed", "about", "0.5", "%", "the", "activity", "of", "T3", "at", "72", "h", "." ]
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15328
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15329
[ "Propylthiouracil", "(", "50", "mumol/L", ")", "did", "not", "affect", "the", "action", "of", "T3SO4", ",", "suggesting", "that", "deiodination", "was", "not", "important", "for", "this", "activity", "of", "T3SO4", "." ]
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15330
[ "Thus", ",", "it", "appears", "T3SO4", "has", "no", "intrinsic", "biological", "activity", ",", "but", ",", "under", "certain", "circumstances", ",", "may", "be", "reactivated", "by", "desulfation", "." ]
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15331
[ "Human", "T", "cell", "activation", "through", "the", "activation-inducer", "molecule/CD69", "enhances", "the", "activity", "of", "transcription", "factor", "AP-1", "." ]
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15332
[ "The", "induction", "of", "the", "AP-1", "transcription", "factor", "has", "been", "ascribed", "to", "the", "early", "events", "leading", "to", "T", "cell", "differentiation", "and", "activation", "." ]
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15333
[ "We", "have", "studied", "the", "regulation", "of", "AP-1", "activity", "in", "human", "peripheral", "blood", "T", "lymphocytes", "stimulated", "through", "the", "activation", "inducer", "molecule", "(", "AIM", ")", "/", "CD69", "activation", "pathway", "." ]
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15334
[ "Phorbol", "esters", "are", "required", "to", "induce", "AIM/CD69", "cell-surface", "expression", "as", "well", "as", "for", "triggering", "the", "proliferation", "of", "T", "cells", "in", "conjunction", "with", "anti-AIM", "mAb", "." ]
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15335
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15336
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15337
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15338
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15339
[ "Most", "of", "the", "AP-1", "activity", "could", "be", "eliminated", "when", "the", "anti-AIM", "mAb", "was", "added", "to", "the", "culture", "medium", "in", "the", "presence", "of", "cycloheximide", ",", "suggesting", "that", "de", "novo", "protein", "synthesis", "is", "crucial", "for", "the", "induction", "of", "AP-1", "-binding", "activity", "." ]
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15340
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15341
[ "Therefore", ",", "this", "pathway", "appears", "as", "a", "crucial", "step", "in", "the", "initiation", "of", "early", "T", "cell", "activation", "events", "." ]
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15342
[ "Gangliosides", "suppress", "tumor", "necrosis", "factor", "production", "in", "human", "monocytes", "." ]
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15343
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15344
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15345
[ "Although", "under", "standard", "culture", "conditions", ",", "bovine", "brain", "gangliosides", "(", "100", "micrograms/ml", ")", "suppressed", "LPS-stimulated", "TNF", "production", "5-fold", "in", "PBMC", "and", "10-fold", "in", "Mono", "Mac", "6", "cells", ",", "suppression", "was", "more", "efficient", "under", "serum-free", "conditions", "." ]
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15346
[ "Looking", "at", "highly", "purified", "gangliosides", ",", "GD3", ",", "GD1a", ",", "GM3", ",", "GM2", ",", "and", "GM1", "were", "all", "effective", "in", "reducing", "TNF", "production", "in", "PBMC", ",", "and", "in", "Mono", "Mac", "6", "by", "factor", "10", "to", "50", "." ]
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15347
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15348
[ "Gangliosides", "appear", "to", "act", "at", "an", "early", "step", "of", "activation", "in", "that", "TNF", "transcripts", "were", "reduced", "and", "the", "mobilization", "of", "the", "nuclear", "factor", "kappa", "B", "was", "blocked", "." ]
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15349
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15350
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15351
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15352
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15364
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15367
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15371
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15374
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15375
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15380
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15381
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15382
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15384
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15392
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