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SQuAD
In empirical therapy, a patient has proven or suspected infection, but the responsible microorganism is not yet unidentified. While the microorgainsim is being identified the doctor will usually administer the best choice of antibiotic that will be most active against the likely cause of infection usually a broad spectrum antibiotic. Empirical therapy is usually initiated before the doctor knows the exact identification of microorgansim causing the infection as the identification process make take several days in the laboratory.
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8600d7cab9384ab19f8bff3bd08389a7
What happens when a doctor doesn't know the microorganism yet?
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{ "text": [ "broad spectrum antibiotic" ], "char_spans": [ { "start": [ 309 ], "end": [ 333 ] } ], "token_spans": [ { "start": [ 50 ], "end": [ 52 ] } ] }
[ "broad spectrum antibiotic" ]
SQuAD
In empirical therapy, a patient has proven or suspected infection, but the responsible microorganism is not yet unidentified. While the microorgainsim is being identified the doctor will usually administer the best choice of antibiotic that will be most active against the likely cause of infection usually a broad spectrum antibiotic. Empirical therapy is usually initiated before the doctor knows the exact identification of microorgansim causing the infection as the identification process make take several days in the laboratory.
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58473f842ad940769adb7273a75c2a92
What happens in empirical therapy?
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[ "a patient has proven or suspected infection, but the responsible microorganism is not yet unidentified" ]
SQuAD
In empirical therapy, a patient has proven or suspected infection, but the responsible microorganism is not yet unidentified. While the microorgainsim is being identified the doctor will usually administer the best choice of antibiotic that will be most active against the likely cause of infection usually a broad spectrum antibiotic. Empirical therapy is usually initiated before the doctor knows the exact identification of microorgansim causing the infection as the identification process make take several days in the laboratory.
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5f66ec4113ca45b088c855be81360a58
When is empirical started?
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{ "text": [ "before the doctor knows the exact identification of microorgansim" ], "char_spans": [ { "start": [ 375 ], "end": [ 439 ] } ], "token_spans": [ { "start": [ 59 ], "end": [ 67 ] } ] }
[ "before the doctor knows the exact identification of microorgansim" ]
SQuAD
With advances in medicinal chemistry, most modern antibacterials are semisynthetic modifications of various natural compounds. These include, for example, the beta-lactam antibiotics, which include the penicillins (produced by fungi in the genus Penicillium), the cephalosporins, and the carbapenems. Compounds that are still isolated from living organisms are the aminoglycosides, whereas other antibacterials—for example, the sulfonamides, the quinolones, and the oxazolidinones—are produced solely by chemical synthesis. Many antibacterial compounds are relatively small molecules with a molecular weight of less than 2000 atomic mass units.[citation needed]
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4b7f1a4bb67c48a7a6cc0834db4d53e7
What are antibiotics in chemical terms?
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{ "text": [ "semisynthetic modifications" ], "char_spans": [ { "start": [ 69 ], "end": [ 95 ] } ], "token_spans": [ { "start": [ 10 ], "end": [ 11 ] } ] }
[ "semisynthetic modifications" ]
SQuAD
With advances in medicinal chemistry, most modern antibacterials are semisynthetic modifications of various natural compounds. These include, for example, the beta-lactam antibiotics, which include the penicillins (produced by fungi in the genus Penicillium), the cephalosporins, and the carbapenems. Compounds that are still isolated from living organisms are the aminoglycosides, whereas other antibacterials—for example, the sulfonamides, the quinolones, and the oxazolidinones—are produced solely by chemical synthesis. Many antibacterial compounds are relatively small molecules with a molecular weight of less than 2000 atomic mass units.[citation needed]
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a2756009e9894ccfa93333aa8b9579d9
What type of antibiotics include penicilin?
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{ "text": [ "beta-lactam antibiotics" ], "char_spans": [ { "start": [ 159 ], "end": [ 181 ] } ], "token_spans": [ { "start": [ 24 ], "end": [ 27 ] } ] }
[ "beta-lactam antibiotics" ]
SQuAD
With advances in medicinal chemistry, most modern antibacterials are semisynthetic modifications of various natural compounds. These include, for example, the beta-lactam antibiotics, which include the penicillins (produced by fungi in the genus Penicillium), the cephalosporins, and the carbapenems. Compounds that are still isolated from living organisms are the aminoglycosides, whereas other antibacterials—for example, the sulfonamides, the quinolones, and the oxazolidinones—are produced solely by chemical synthesis. Many antibacterial compounds are relatively small molecules with a molecular weight of less than 2000 atomic mass units.[citation needed]
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5cbfb77ba3754663b2f823683c02bd4f
What are the type of antibiotics which are taken from still living things?
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{ "text": [ "aminoglycosides" ], "char_spans": [ { "start": [ 365 ], "end": [ 379 ] } ], "token_spans": [ { "start": [ 60 ], "end": [ 60 ] } ] }
[ "aminoglycosides" ]
SQuAD
With advances in medicinal chemistry, most modern antibacterials are semisynthetic modifications of various natural compounds. These include, for example, the beta-lactam antibiotics, which include the penicillins (produced by fungi in the genus Penicillium), the cephalosporins, and the carbapenems. Compounds that are still isolated from living organisms are the aminoglycosides, whereas other antibacterials—for example, the sulfonamides, the quinolones, and the oxazolidinones—are produced solely by chemical synthesis. Many antibacterial compounds are relatively small molecules with a molecular weight of less than 2000 atomic mass units.[citation needed]
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926b1648f4854bb1b867a98476826516
How are the slufonamides,quinolones, and oxazolidinones created?
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[ "synthesis" ]
SQuAD
With advances in medicinal chemistry, most modern antibacterials are semisynthetic modifications of various natural compounds. These include, for example, the beta-lactam antibiotics, which include the penicillins (produced by fungi in the genus Penicillium), the cephalosporins, and the carbapenems. Compounds that are still isolated from living organisms are the aminoglycosides, whereas other antibacterials—for example, the sulfonamides, the quinolones, and the oxazolidinones—are produced solely by chemical synthesis. Many antibacterial compounds are relatively small molecules with a molecular weight of less than 2000 atomic mass units.[citation needed]
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df6c2af362d64136a69263d0b8a06f52
Besides semisytetic modifications, what advances in medicinal chemistry regarding antibacterials?
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{ "text": [ "various natural compounds" ], "char_spans": [ { "start": [ 100 ], "end": [ 124 ] } ], "token_spans": [ { "start": [ 13 ], "end": [ 15 ] } ] }
[ "various natural compounds" ]
SQuAD
With advances in medicinal chemistry, most modern antibacterials are semisynthetic modifications of various natural compounds. These include, for example, the beta-lactam antibiotics, which include the penicillins (produced by fungi in the genus Penicillium), the cephalosporins, and the carbapenems. Compounds that are still isolated from living organisms are the aminoglycosides, whereas other antibacterials—for example, the sulfonamides, the quinolones, and the oxazolidinones—are produced solely by chemical synthesis. Many antibacterial compounds are relatively small molecules with a molecular weight of less than 2000 atomic mass units.[citation needed]
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0e6aee774a0b4937a65c4a54175968fd
What is included in the beta-lactam antibiotics?
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{ "text": [ "penicillins" ], "char_spans": [ { "start": [ 202 ], "end": [ 212 ] } ], "token_spans": [ { "start": [ 32 ], "end": [ 32 ] } ] }
[ "penicillins" ]
SQuAD
With advances in medicinal chemistry, most modern antibacterials are semisynthetic modifications of various natural compounds. These include, for example, the beta-lactam antibiotics, which include the penicillins (produced by fungi in the genus Penicillium), the cephalosporins, and the carbapenems. Compounds that are still isolated from living organisms are the aminoglycosides, whereas other antibacterials—for example, the sulfonamides, the quinolones, and the oxazolidinones—are produced solely by chemical synthesis. Many antibacterial compounds are relatively small molecules with a molecular weight of less than 2000 atomic mass units.[citation needed]
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ac11e227e8d3474f8174dfdb35ce6dcf
What is penicillins produced by?
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{ "text": [ "fungi" ], "char_spans": [ { "start": [ 227 ], "end": [ 231 ] } ], "token_spans": [ { "start": [ 36 ], "end": [ 36 ] } ] }
[ "fungi" ]
SQuAD
The successful outcome of antimicrobial therapy with antibacterial compounds depends on several factors. These include host defense mechanisms, the location of infection, and the pharmacokinetic and pharmacodynamic properties of the antibacterial. A bactericidal activity of antibacterials may depend on the bacterial growth phase, and it often requires ongoing metabolic activity and division of bacterial cells. These findings are based on laboratory studies, and in clinical settings have also been shown to eliminate bacterial infection. Since the activity of antibacterials depends frequently on its concentration, in vitro characterization of antibacterial activity commonly includes the determination of the minimum inhibitory concentration and minimum bactericidal concentration of an antibacterial. To predict clinical outcome, the antimicrobial activity of an antibacterial is usually combined with its pharmacokinetic profile, and several pharmacological parameters are used as markers of drug efficacy.
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42a6f253cbf343af8c9db919376fc6fe
What does the potency of antibacterials depend upon?
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{ "text": [ "concentration" ], "char_spans": [ { "start": [ 605 ], "end": [ 617 ] } ], "token_spans": [ { "start": [ 91 ], "end": [ 91 ] } ] }
[ "concentration" ]
SQuAD
The successful outcome of antimicrobial therapy with antibacterial compounds depends on several factors. These include host defense mechanisms, the location of infection, and the pharmacokinetic and pharmacodynamic properties of the antibacterial. A bactericidal activity of antibacterials may depend on the bacterial growth phase, and it often requires ongoing metabolic activity and division of bacterial cells. These findings are based on laboratory studies, and in clinical settings have also been shown to eliminate bacterial infection. Since the activity of antibacterials depends frequently on its concentration, in vitro characterization of antibacterial activity commonly includes the determination of the minimum inhibitory concentration and minimum bactericidal concentration of an antibacterial. To predict clinical outcome, the antimicrobial activity of an antibacterial is usually combined with its pharmacokinetic profile, and several pharmacological parameters are used as markers of drug efficacy.
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5755d5c0dc93471f81c31a123b7e04cd
What does this eliminate?
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{ "text": [ "bacterial infection" ], "char_spans": [ { "start": [ 521 ], "end": [ 539 ] } ], "token_spans": [ { "start": [ 79 ], "end": [ 80 ] } ] }
[ "bacterial infection" ]
SQuAD
The successful outcome of antimicrobial therapy with antibacterial compounds depends on several factors. These include host defense mechanisms, the location of infection, and the pharmacokinetic and pharmacodynamic properties of the antibacterial. A bactericidal activity of antibacterials may depend on the bacterial growth phase, and it often requires ongoing metabolic activity and division of bacterial cells. These findings are based on laboratory studies, and in clinical settings have also been shown to eliminate bacterial infection. Since the activity of antibacterials depends frequently on its concentration, in vitro characterization of antibacterial activity commonly includes the determination of the minimum inhibitory concentration and minimum bactericidal concentration of an antibacterial. To predict clinical outcome, the antimicrobial activity of an antibacterial is usually combined with its pharmacokinetic profile, and several pharmacological parameters are used as markers of drug efficacy.
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42aad83d0037434eb3c2cd582df0d9e3
What does the bactericidal activitty of antibacterials depend on what?
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{ "text": [ "bacterial growth phase" ], "char_spans": [ { "start": [ 308 ], "end": [ 329 ] } ], "token_spans": [ { "start": [ 44 ], "end": [ 46 ] } ] }
[ "bacterial growth phase" ]
SQuAD
The successful outcome of antimicrobial therapy with antibacterial compounds depends on several factors. These include host defense mechanisms, the location of infection, and the pharmacokinetic and pharmacodynamic properties of the antibacterial. A bactericidal activity of antibacterials may depend on the bacterial growth phase, and it often requires ongoing metabolic activity and division of bacterial cells. These findings are based on laboratory studies, and in clinical settings have also been shown to eliminate bacterial infection. Since the activity of antibacterials depends frequently on its concentration, in vitro characterization of antibacterial activity commonly includes the determination of the minimum inhibitory concentration and minimum bactericidal concentration of an antibacterial. To predict clinical outcome, the antimicrobial activity of an antibacterial is usually combined with its pharmacokinetic profile, and several pharmacological parameters are used as markers of drug efficacy.
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925bd74725c54734a5dd43e633d8d775
What besides ongoing metabolic activity is required in bactericidal activity?
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{ "text": [ "division of bacterial cells" ], "char_spans": [ { "start": [ 385 ], "end": [ 411 ] } ], "token_spans": [ { "start": [ 56 ], "end": [ 59 ] } ] }
[ "division of bacterial cells" ]
SQuAD
The successful outcome of antimicrobial therapy with antibacterial compounds depends on several factors. These include host defense mechanisms, the location of infection, and the pharmacokinetic and pharmacodynamic properties of the antibacterial. A bactericidal activity of antibacterials may depend on the bacterial growth phase, and it often requires ongoing metabolic activity and division of bacterial cells. These findings are based on laboratory studies, and in clinical settings have also been shown to eliminate bacterial infection. Since the activity of antibacterials depends frequently on its concentration, in vitro characterization of antibacterial activity commonly includes the determination of the minimum inhibitory concentration and minimum bactericidal concentration of an antibacterial. To predict clinical outcome, the antimicrobial activity of an antibacterial is usually combined with its pharmacokinetic profile, and several pharmacological parameters are used as markers of drug efficacy.
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642dd4bedb9e44c597fc1adcd66e61f4
What does the activity of antibacterials depends on?
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{ "text": [ "concentration" ], "char_spans": [ { "start": [ 605 ], "end": [ 617 ] } ], "token_spans": [ { "start": [ 91 ], "end": [ 91 ] } ] }
[ "concentration" ]
SQuAD
The successful outcome of antimicrobial therapy with antibacterial compounds depends on several factors. These include host defense mechanisms, the location of infection, and the pharmacokinetic and pharmacodynamic properties of the antibacterial. A bactericidal activity of antibacterials may depend on the bacterial growth phase, and it often requires ongoing metabolic activity and division of bacterial cells. These findings are based on laboratory studies, and in clinical settings have also been shown to eliminate bacterial infection. Since the activity of antibacterials depends frequently on its concentration, in vitro characterization of antibacterial activity commonly includes the determination of the minimum inhibitory concentration and minimum bactericidal concentration of an antibacterial. To predict clinical outcome, the antimicrobial activity of an antibacterial is usually combined with its pharmacokinetic profile, and several pharmacological parameters are used as markers of drug efficacy.
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4e82f1f74c0f4c398c0f9aa867aca074
What does a successful treatment using antibiotics entail?
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{ "text": [ "host defense mechanisms, the location of infection, and the pharmacokinetic and pharmacodynamic properties of the antibacterial" ], "char_spans": [ { "start": [ 119 ], "end": [ 245 ] } ], "token_spans": [ { "start": [ 16 ], "end": [ 33 ] } ] }
[ "host defense mechanisms, the location of infection, and the pharmacokinetic and pharmacodynamic properties of the antibacterial" ]
SQuAD
The successful outcome of antimicrobial therapy with antibacterial compounds depends on several factors. These include host defense mechanisms, the location of infection, and the pharmacokinetic and pharmacodynamic properties of the antibacterial. A bactericidal activity of antibacterials may depend on the bacterial growth phase, and it often requires ongoing metabolic activity and division of bacterial cells. These findings are based on laboratory studies, and in clinical settings have also been shown to eliminate bacterial infection. Since the activity of antibacterials depends frequently on its concentration, in vitro characterization of antibacterial activity commonly includes the determination of the minimum inhibitory concentration and minimum bactericidal concentration of an antibacterial. To predict clinical outcome, the antimicrobial activity of an antibacterial is usually combined with its pharmacokinetic profile, and several pharmacological parameters are used as markers of drug efficacy.
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8110da6157f0417fa1fbc357488d2429
How do you predict the clinical result?
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{ "text": [ "several pharmacological parameters are used as markers of drug efficacy" ], "char_spans": [ { "start": [ 942 ], "end": [ 1012 ] } ], "token_spans": [ { "start": [ 136 ], "end": [ 145 ] } ] }
[ "several pharmacological parameters are used as markers of drug efficacy" ]
SQuAD
Other authors have focused on the structural conditions leading up to genocide and the psychological and social processes that create an evolution toward genocide. Ervin Staub showed that economic deterioration and political confusion and disorganization were starting points of increasing discrimination and violence in many instances of genocides and mass killing. They lead to scapegoating a group and ideologies that identified that group as an enemy. A history of devaluation of the group that becomes the victim, past violence against the group that becomes the perpetrator leading to psychological wounds, authoritarian cultures and political systems, and the passivity of internal and external witnesses (bystanders) all contribute to the probability that the violence develops into genocide. Intense conflict between groups that is unresolved, becomes intractable and violent can also lead to genocide. The conditions that lead to genocide provide guidance to early prevention, such as humanizing a devalued group, creating ideologies that embrace all groups, and activating bystander responses. There is substantial research to indicate how this can be done, but information is only slowly transformed into action.
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ca251c37b4e749f19006422b73822b53
In the build-up to genocide, what have other authors focused on?
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{ "text": [ "structural conditions" ], "char_spans": [ { "start": [ 34 ], "end": [ 54 ] } ], "token_spans": [ { "start": [ 6 ], "end": [ 7 ] } ] }
[ "structural conditions" ]
SQuAD
Other authors have focused on the structural conditions leading up to genocide and the psychological and social processes that create an evolution toward genocide. Ervin Staub showed that economic deterioration and political confusion and disorganization were starting points of increasing discrimination and violence in many instances of genocides and mass killing. They lead to scapegoating a group and ideologies that identified that group as an enemy. A history of devaluation of the group that becomes the victim, past violence against the group that becomes the perpetrator leading to psychological wounds, authoritarian cultures and political systems, and the passivity of internal and external witnesses (bystanders) all contribute to the probability that the violence develops into genocide. Intense conflict between groups that is unresolved, becomes intractable and violent can also lead to genocide. The conditions that lead to genocide provide guidance to early prevention, such as humanizing a devalued group, creating ideologies that embrace all groups, and activating bystander responses. There is substantial research to indicate how this can be done, but information is only slowly transformed into action.
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f79c89a274574a3ab415f6e03a3ad073
What processes are thought to create an evolution toward genocide?
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{ "text": [ "psychological and social" ], "char_spans": [ { "start": [ 87 ], "end": [ 110 ] } ], "token_spans": [ { "start": [ 14 ], "end": [ 16 ] } ] }
[ "psychological and social" ]
SQuAD
Other authors have focused on the structural conditions leading up to genocide and the psychological and social processes that create an evolution toward genocide. Ervin Staub showed that economic deterioration and political confusion and disorganization were starting points of increasing discrimination and violence in many instances of genocides and mass killing. They lead to scapegoating a group and ideologies that identified that group as an enemy. A history of devaluation of the group that becomes the victim, past violence against the group that becomes the perpetrator leading to psychological wounds, authoritarian cultures and political systems, and the passivity of internal and external witnesses (bystanders) all contribute to the probability that the violence develops into genocide. Intense conflict between groups that is unresolved, becomes intractable and violent can also lead to genocide. The conditions that lead to genocide provide guidance to early prevention, such as humanizing a devalued group, creating ideologies that embrace all groups, and activating bystander responses. There is substantial research to indicate how this can be done, but information is only slowly transformed into action.
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ce94c0543aca436a95dd9442976595be
Who revealed the starting points of this evolution to be economic deterioration and political confusion?
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{ "text": [ "Ervin Staub" ], "char_spans": [ { "start": [ 164 ], "end": [ 174 ] } ], "token_spans": [ { "start": [ 25 ], "end": [ 26 ] } ] }
[ "Ervin Staub" ]
SQuAD
Other authors have focused on the structural conditions leading up to genocide and the psychological and social processes that create an evolution toward genocide. Ervin Staub showed that economic deterioration and political confusion and disorganization were starting points of increasing discrimination and violence in many instances of genocides and mass killing. They lead to scapegoating a group and ideologies that identified that group as an enemy. A history of devaluation of the group that becomes the victim, past violence against the group that becomes the perpetrator leading to psychological wounds, authoritarian cultures and political systems, and the passivity of internal and external witnesses (bystanders) all contribute to the probability that the violence develops into genocide. Intense conflict between groups that is unresolved, becomes intractable and violent can also lead to genocide. The conditions that lead to genocide provide guidance to early prevention, such as humanizing a devalued group, creating ideologies that embrace all groups, and activating bystander responses. There is substantial research to indicate how this can be done, but information is only slowly transformed into action.
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0f1d6be2312848818bb024e19133785f
A history of what is just one factor that contributes to the probability of violence developing into genocide?
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{ "text": [ "devaluation of the group" ], "char_spans": [ { "start": [ 469 ], "end": [ 492 ] } ], "token_spans": [ { "start": [ 72 ], "end": [ 75 ] } ] }
[ "devaluation of the group" ]
SQuAD
Other authors have focused on the structural conditions leading up to genocide and the psychological and social processes that create an evolution toward genocide. Ervin Staub showed that economic deterioration and political confusion and disorganization were starting points of increasing discrimination and violence in many instances of genocides and mass killing. They lead to scapegoating a group and ideologies that identified that group as an enemy. A history of devaluation of the group that becomes the victim, past violence against the group that becomes the perpetrator leading to psychological wounds, authoritarian cultures and political systems, and the passivity of internal and external witnesses (bystanders) all contribute to the probability that the violence develops into genocide. Intense conflict between groups that is unresolved, becomes intractable and violent can also lead to genocide. The conditions that lead to genocide provide guidance to early prevention, such as humanizing a devalued group, creating ideologies that embrace all groups, and activating bystander responses. There is substantial research to indicate how this can be done, but information is only slowly transformed into action.
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77b30db488e54a29bfd248d0d910d3de
What is one preventive effort in circumventing conditions that lead to genocide?
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[ "humanizing a devalued group" ]
SQuAD
Jonassohn and Björnson postulate that the major reason why no single generally accepted genocide definition has emerged is because academics have adjusted their focus to emphasise different periods and have found it expedient to use slightly different definitions to help them interpret events. For example, Frank Chalk and Kurt Jonassohn studied the whole of human history, while Leo Kuper and R. J. Rummel in their more recent works concentrated on the 20th century, and Helen Fein, Barbara Harff and Ted Gurr have looked at post World War II events. Jonassohn and Björnson are critical of some of these studies, arguing that they are too expansive, and conclude that the academic discipline of genocide studies is too young to have a canon of work on which to build an academic paradigm.
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c83ace4e46044af9a417c9e4b1c2a8c7
What two writers examined the lack of an accepted and singular definition for genocide?
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[ "Jonassohn and Björnson" ]
SQuAD
Jonassohn and Björnson postulate that the major reason why no single generally accepted genocide definition has emerged is because academics have adjusted their focus to emphasise different periods and have found it expedient to use slightly different definitions to help them interpret events. For example, Frank Chalk and Kurt Jonassohn studied the whole of human history, while Leo Kuper and R. J. Rummel in their more recent works concentrated on the 20th century, and Helen Fein, Barbara Harff and Ted Gurr have looked at post World War II events. Jonassohn and Björnson are critical of some of these studies, arguing that they are too expansive, and conclude that the academic discipline of genocide studies is too young to have a canon of work on which to build an academic paradigm.
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200fb7e4b5ac4aeaad5ddfdb259fdac9
The two writers suggested that academics adjusted what in their different definitions to assist them in interpreting events?
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[ "their focus" ]
SQuAD
Jonassohn and Björnson postulate that the major reason why no single generally accepted genocide definition has emerged is because academics have adjusted their focus to emphasise different periods and have found it expedient to use slightly different definitions to help them interpret events. For example, Frank Chalk and Kurt Jonassohn studied the whole of human history, while Leo Kuper and R. J. Rummel in their more recent works concentrated on the 20th century, and Helen Fein, Barbara Harff and Ted Gurr have looked at post World War II events. Jonassohn and Björnson are critical of some of these studies, arguing that they are too expansive, and conclude that the academic discipline of genocide studies is too young to have a canon of work on which to build an academic paradigm.
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dec13f7df8e44db594808f1d80833178
What writer joined Jonassohn in the study of the whole of human history?
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{ "text": [ "Frank Chalk" ], "char_spans": [ { "start": [ 308 ], "end": [ 318 ] } ], "token_spans": [ { "start": [ 47 ], "end": [ 48 ] } ] }
[ "Frank Chalk" ]
SQuAD
Jonassohn and Björnson postulate that the major reason why no single generally accepted genocide definition has emerged is because academics have adjusted their focus to emphasise different periods and have found it expedient to use slightly different definitions to help them interpret events. For example, Frank Chalk and Kurt Jonassohn studied the whole of human history, while Leo Kuper and R. J. Rummel in their more recent works concentrated on the 20th century, and Helen Fein, Barbara Harff and Ted Gurr have looked at post World War II events. Jonassohn and Björnson are critical of some of these studies, arguing that they are too expansive, and conclude that the academic discipline of genocide studies is too young to have a canon of work on which to build an academic paradigm.
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e4dfbf2638d34766b5371f5012334250
With whom was Leo Kuper paired in research that focused on 20th century works?
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{ "text": [ "R. J. Rummel" ], "char_spans": [ { "start": [ 395 ], "end": [ 406 ] } ], "token_spans": [ { "start": [ 63 ], "end": [ 65 ] } ] }
[ "R. J. Rummel" ]
SQuAD
Jonassohn and Björnson postulate that the major reason why no single generally accepted genocide definition has emerged is because academics have adjusted their focus to emphasise different periods and have found it expedient to use slightly different definitions to help them interpret events. For example, Frank Chalk and Kurt Jonassohn studied the whole of human history, while Leo Kuper and R. J. Rummel in their more recent works concentrated on the 20th century, and Helen Fein, Barbara Harff and Ted Gurr have looked at post World War II events. Jonassohn and Björnson are critical of some of these studies, arguing that they are too expansive, and conclude that the academic discipline of genocide studies is too young to have a canon of work on which to build an academic paradigm.
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67a9a4dfef754bb68731f56bba246b15
Two women and what man concentrated on post World War II events?
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{ "text": [ "Ted Gurr" ], "char_spans": [ { "start": [ 503 ], "end": [ 510 ] } ], "token_spans": [ { "start": [ 84 ], "end": [ 85 ] } ] }
[ "Ted Gurr" ]
SQuAD
Several molecular mechanisms of antibacterial resistance exist. Intrinsic antibacterial resistance may be part of the genetic makeup of bacterial strains. For example, an antibiotic target may be absent from the bacterial genome. Acquired resistance results from a mutation in the bacterial chromosome or the acquisition of extra-chromosomal DNA. Antibacterial-producing bacteria have evolved resistance mechanisms that have been shown to be similar to, and may have been transferred to, antibacterial-resistant strains. The spread of antibacterial resistance often occurs through vertical transmission of mutations during growth and by genetic recombination of DNA by horizontal genetic exchange. For instance, antibacterial resistance genes can be exchanged between different bacterial strains or species via plasmids that carry these resistance genes. Plasmids that carry several different resistance genes can confer resistance to multiple antibacterials. Cross-resistance to several antibacterials may also occur when a resistance mechanism encoded by a single gene conveys resistance to more than one antibacterial compound.
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737eb78050f743b496d9ec95a6843686
What is part of hje the make up of bacterial strains?
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{ "text": [ "Intrinsic antibacterial resistance" ], "char_spans": [ { "start": [ 64 ], "end": [ 97 ] } ], "token_spans": [ { "start": [ 8 ], "end": [ 10 ] } ] }
[ "Intrinsic antibacterial resistance" ]
SQuAD
Several molecular mechanisms of antibacterial resistance exist. Intrinsic antibacterial resistance may be part of the genetic makeup of bacterial strains. For example, an antibiotic target may be absent from the bacterial genome. Acquired resistance results from a mutation in the bacterial chromosome or the acquisition of extra-chromosomal DNA. Antibacterial-producing bacteria have evolved resistance mechanisms that have been shown to be similar to, and may have been transferred to, antibacterial-resistant strains. The spread of antibacterial resistance often occurs through vertical transmission of mutations during growth and by genetic recombination of DNA by horizontal genetic exchange. For instance, antibacterial resistance genes can be exchanged between different bacterial strains or species via plasmids that carry these resistance genes. Plasmids that carry several different resistance genes can confer resistance to multiple antibacterials. Cross-resistance to several antibacterials may also occur when a resistance mechanism encoded by a single gene conveys resistance to more than one antibacterial compound.
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12c3627c318f4c3d839ed4a6643b2280
What is exchanged between between bacterial strains or species via plasmids that have this resistance?
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{ "text": [ "antibacterial resistance genes" ], "char_spans": [ { "start": [ 712 ], "end": [ 741 ] } ], "token_spans": [ { "start": [ 112 ], "end": [ 114 ] } ] }
[ "antibacterial resistance genes" ]
SQuAD
Several molecular mechanisms of antibacterial resistance exist. Intrinsic antibacterial resistance may be part of the genetic makeup of bacterial strains. For example, an antibiotic target may be absent from the bacterial genome. Acquired resistance results from a mutation in the bacterial chromosome or the acquisition of extra-chromosomal DNA. Antibacterial-producing bacteria have evolved resistance mechanisms that have been shown to be similar to, and may have been transferred to, antibacterial-resistant strains. The spread of antibacterial resistance often occurs through vertical transmission of mutations during growth and by genetic recombination of DNA by horizontal genetic exchange. For instance, antibacterial resistance genes can be exchanged between different bacterial strains or species via plasmids that carry these resistance genes. Plasmids that carry several different resistance genes can confer resistance to multiple antibacterials. Cross-resistance to several antibacterials may also occur when a resistance mechanism encoded by a single gene conveys resistance to more than one antibacterial compound.
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051c0bfff377470ebb8da0d751d76700
What can be absent from the bacterial genome?
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{ "text": [ "antibiotic target" ], "char_spans": [ { "start": [ 171 ], "end": [ 187 ] } ], "token_spans": [ { "start": [ 26 ], "end": [ 27 ] } ] }
[ "antibiotic target" ]
SQuAD
Several molecular mechanisms of antibacterial resistance exist. Intrinsic antibacterial resistance may be part of the genetic makeup of bacterial strains. For example, an antibiotic target may be absent from the bacterial genome. Acquired resistance results from a mutation in the bacterial chromosome or the acquisition of extra-chromosomal DNA. Antibacterial-producing bacteria have evolved resistance mechanisms that have been shown to be similar to, and may have been transferred to, antibacterial-resistant strains. The spread of antibacterial resistance often occurs through vertical transmission of mutations during growth and by genetic recombination of DNA by horizontal genetic exchange. For instance, antibacterial resistance genes can be exchanged between different bacterial strains or species via plasmids that carry these resistance genes. Plasmids that carry several different resistance genes can confer resistance to multiple antibacterials. Cross-resistance to several antibacterials may also occur when a resistance mechanism encoded by a single gene conveys resistance to more than one antibacterial compound.
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2f6174b696344cf09f38ac47425c1419
When does the spread of antibacterial resistance frequently occurs/
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{ "text": [ "vertical transmission" ], "char_spans": [ { "start": [ 581 ], "end": [ 601 ] } ], "token_spans": [ { "start": [ 92 ], "end": [ 93 ] } ] }
[ "vertical transmission" ]
SQuAD
Several molecular mechanisms of antibacterial resistance exist. Intrinsic antibacterial resistance may be part of the genetic makeup of bacterial strains. For example, an antibiotic target may be absent from the bacterial genome. Acquired resistance results from a mutation in the bacterial chromosome or the acquisition of extra-chromosomal DNA. Antibacterial-producing bacteria have evolved resistance mechanisms that have been shown to be similar to, and may have been transferred to, antibacterial-resistant strains. The spread of antibacterial resistance often occurs through vertical transmission of mutations during growth and by genetic recombination of DNA by horizontal genetic exchange. For instance, antibacterial resistance genes can be exchanged between different bacterial strains or species via plasmids that carry these resistance genes. Plasmids that carry several different resistance genes can confer resistance to multiple antibacterials. Cross-resistance to several antibacterials may also occur when a resistance mechanism encoded by a single gene conveys resistance to more than one antibacterial compound.
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91cf767a97174442b8147e0d3d604b97
What does some resistance come from?
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{ "text": [ "mutation" ], "char_spans": [ { "start": [ 265 ], "end": [ 272 ] } ], "token_spans": [ { "start": [ 41 ], "end": [ 41 ] } ] }
[ "mutation" ]
SQuAD
Several molecular mechanisms of antibacterial resistance exist. Intrinsic antibacterial resistance may be part of the genetic makeup of bacterial strains. For example, an antibiotic target may be absent from the bacterial genome. Acquired resistance results from a mutation in the bacterial chromosome or the acquisition of extra-chromosomal DNA. Antibacterial-producing bacteria have evolved resistance mechanisms that have been shown to be similar to, and may have been transferred to, antibacterial-resistant strains. The spread of antibacterial resistance often occurs through vertical transmission of mutations during growth and by genetic recombination of DNA by horizontal genetic exchange. For instance, antibacterial resistance genes can be exchanged between different bacterial strains or species via plasmids that carry these resistance genes. Plasmids that carry several different resistance genes can confer resistance to multiple antibacterials. Cross-resistance to several antibacterials may also occur when a resistance mechanism encoded by a single gene conveys resistance to more than one antibacterial compound.
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e3d6f7864ba847a8adf5c67ee5aefd77
What method of spread can occur in antibacterial resistance?
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{ "text": [ "vertical transmission of mutations" ], "char_spans": [ { "start": [ 581 ], "end": [ 614 ] } ], "token_spans": [ { "start": [ 92 ], "end": [ 95 ] } ] }
[ "vertical transmission of mutations" ]
SQuAD
Several molecular mechanisms of antibacterial resistance exist. Intrinsic antibacterial resistance may be part of the genetic makeup of bacterial strains. For example, an antibiotic target may be absent from the bacterial genome. Acquired resistance results from a mutation in the bacterial chromosome or the acquisition of extra-chromosomal DNA. Antibacterial-producing bacteria have evolved resistance mechanisms that have been shown to be similar to, and may have been transferred to, antibacterial-resistant strains. The spread of antibacterial resistance often occurs through vertical transmission of mutations during growth and by genetic recombination of DNA by horizontal genetic exchange. For instance, antibacterial resistance genes can be exchanged between different bacterial strains or species via plasmids that carry these resistance genes. Plasmids that carry several different resistance genes can confer resistance to multiple antibacterials. Cross-resistance to several antibacterials may also occur when a resistance mechanism encoded by a single gene conveys resistance to more than one antibacterial compound.
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e5327b332767476f983a892e790ad6e7
What do plasmids do in resistance?
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{ "text": [ "carry several different resistance genes" ], "char_spans": [ { "start": [ 869 ], "end": [ 908 ] } ], "token_spans": [ { "start": [ 134 ], "end": [ 138 ] } ] }
[ "carry several different resistance genes" ]
SQuAD
The emergence of resistance of bacteria to antibiotics is a common phenomenon. Emergence of resistance often reflects evolutionary processes that take place during antibiotic therapy. The antibiotic treatment may select for bacterial strains with physiologically or genetically enhanced capacity to survive high doses of antibiotics. Under certain conditions, it may result in preferential growth of resistant bacteria, while growth of susceptible bacteria is inhibited by the drug. For example, antibacterial selection for strains having previously acquired antibacterial-resistance genes was demonstrated in 1943 by the Luria–Delbrück experiment. Antibiotics such as penicillin and erythromycin, which used to have a high efficacy against many bacterial species and strains, have become less effective, due to the increased resistance of many bacterial strains.
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240f90d1c3224dad86b3f8c5d0e79625
What is a modern common occurence with antibiotics?
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{ "text": [ "resistance of bacteria" ], "char_spans": [ { "start": [ 17 ], "end": [ 38 ] } ], "token_spans": [ { "start": [ 3 ], "end": [ 5 ] } ] }
[ "resistance of bacteria" ]
SQuAD
The emergence of resistance of bacteria to antibiotics is a common phenomenon. Emergence of resistance often reflects evolutionary processes that take place during antibiotic therapy. The antibiotic treatment may select for bacterial strains with physiologically or genetically enhanced capacity to survive high doses of antibiotics. Under certain conditions, it may result in preferential growth of resistant bacteria, while growth of susceptible bacteria is inhibited by the drug. For example, antibacterial selection for strains having previously acquired antibacterial-resistance genes was demonstrated in 1943 by the Luria–Delbrück experiment. Antibiotics such as penicillin and erythromycin, which used to have a high efficacy against many bacterial species and strains, have become less effective, due to the increased resistance of many bacterial strains.
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4b5b5f8622cf411cb67119615ed784b2
When was the Luria-Delbruck experiment?
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{ "text": [ "1943" ], "char_spans": [ { "start": [ 610 ], "end": [ 613 ] } ], "token_spans": [ { "start": [ 90 ], "end": [ 90 ] } ] }
[ "1943" ]
SQuAD
The emergence of resistance of bacteria to antibiotics is a common phenomenon. Emergence of resistance often reflects evolutionary processes that take place during antibiotic therapy. The antibiotic treatment may select for bacterial strains with physiologically or genetically enhanced capacity to survive high doses of antibiotics. Under certain conditions, it may result in preferential growth of resistant bacteria, while growth of susceptible bacteria is inhibited by the drug. For example, antibacterial selection for strains having previously acquired antibacterial-resistance genes was demonstrated in 1943 by the Luria–Delbrück experiment. Antibiotics such as penicillin and erythromycin, which used to have a high efficacy against many bacterial species and strains, have become less effective, due to the increased resistance of many bacterial strains.
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0e54f565b22d4854be314cc8c25eac32
Which two antibiotics that have high efficacy are much less useful now?
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{ "text": [ "penicillin and erythromycin" ], "char_spans": [ { "start": [ 669 ], "end": [ 695 ] } ], "token_spans": [ { "start": [ 101 ], "end": [ 103 ] } ] }
[ "penicillin and erythromycin" ]
SQuAD
The emergence of resistance of bacteria to antibiotics is a common phenomenon. Emergence of resistance often reflects evolutionary processes that take place during antibiotic therapy. The antibiotic treatment may select for bacterial strains with physiologically or genetically enhanced capacity to survive high doses of antibiotics. Under certain conditions, it may result in preferential growth of resistant bacteria, while growth of susceptible bacteria is inhibited by the drug. For example, antibacterial selection for strains having previously acquired antibacterial-resistance genes was demonstrated in 1943 by the Luria–Delbrück experiment. Antibiotics such as penicillin and erythromycin, which used to have a high efficacy against many bacterial species and strains, have become less effective, due to the increased resistance of many bacterial strains.
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3a8994cdf0304cd1bf8c66fb51d8f7db
What does emergence of resistance reflect?
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{ "text": [ "evolutionary processes" ], "char_spans": [ { "start": [ 118 ], "end": [ 139 ] } ], "token_spans": [ { "start": [ 18 ], "end": [ 19 ] } ] }
[ "evolutionary processes" ]
SQuAD
The emergence of resistance of bacteria to antibiotics is a common phenomenon. Emergence of resistance often reflects evolutionary processes that take place during antibiotic therapy. The antibiotic treatment may select for bacterial strains with physiologically or genetically enhanced capacity to survive high doses of antibiotics. Under certain conditions, it may result in preferential growth of resistant bacteria, while growth of susceptible bacteria is inhibited by the drug. For example, antibacterial selection for strains having previously acquired antibacterial-resistance genes was demonstrated in 1943 by the Luria–Delbrück experiment. Antibiotics such as penicillin and erythromycin, which used to have a high efficacy against many bacterial species and strains, have become less effective, due to the increased resistance of many bacterial strains.
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299d7812db11465f95eec9fc52b274dd
What is the purpose of antibiotic treatment?
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{ "text": [ "survive high doses of antibiotics" ], "char_spans": [ { "start": [ 299 ], "end": [ 331 ] } ], "token_spans": [ { "start": [ 42 ], "end": [ 46 ] } ] }
[ "survive high doses of antibiotics" ]
SQuAD
The emergence of resistance of bacteria to antibiotics is a common phenomenon. Emergence of resistance often reflects evolutionary processes that take place during antibiotic therapy. The antibiotic treatment may select for bacterial strains with physiologically or genetically enhanced capacity to survive high doses of antibiotics. Under certain conditions, it may result in preferential growth of resistant bacteria, while growth of susceptible bacteria is inhibited by the drug. For example, antibacterial selection for strains having previously acquired antibacterial-resistance genes was demonstrated in 1943 by the Luria–Delbrück experiment. Antibiotics such as penicillin and erythromycin, which used to have a high efficacy against many bacterial species and strains, have become less effective, due to the increased resistance of many bacterial strains.
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1cd5d74a7e29415aada5f0c456f018d4
When was antibacterial-resistance demonstrated?
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{ "text": [ "1943" ], "char_spans": [ { "start": [ 610 ], "end": [ 613 ] } ], "token_spans": [ { "start": [ 90 ], "end": [ 90 ] } ] }
[ "1943" ]
SQuAD
The emergence of resistance of bacteria to antibiotics is a common phenomenon. Emergence of resistance often reflects evolutionary processes that take place during antibiotic therapy. The antibiotic treatment may select for bacterial strains with physiologically or genetically enhanced capacity to survive high doses of antibiotics. Under certain conditions, it may result in preferential growth of resistant bacteria, while growth of susceptible bacteria is inhibited by the drug. For example, antibacterial selection for strains having previously acquired antibacterial-resistance genes was demonstrated in 1943 by the Luria–Delbrück experiment. Antibiotics such as penicillin and erythromycin, which used to have a high efficacy against many bacterial species and strains, have become less effective, due to the increased resistance of many bacterial strains.
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01b108445c3743d89e9c34f366c0cf62
Who made the demonstration in 1943?
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{ "text": [ "Luria–Delbrück" ], "char_spans": [ { "start": [ 622 ], "end": [ 635 ] } ], "token_spans": [ { "start": [ 93 ], "end": [ 95 ] } ] }
[ "Luria–Delbrück" ]
SQuAD
The effects of some types of mold on infection had been noticed many times over the course of history (see: History of penicillin). In 1928, Alexander Fleming noticed the same effect in a Petri dish, where a number of disease-causing bacteria were killed by a fungus of the genus Penicillium. Fleming postulated that the effect is mediated by an antibacterial compound he named penicillin, and that its antibacterial properties could be exploited for chemotherapy. He initially characterized some of its biological properties, and attempted to use a crude preparation to treat some infections, but he was unable to pursue its further development without the aid of trained chemists.
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23972488f5714bcd9b82b10cd6a10d3c
What type of organism has been reported to have worked on infections?
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{ "text": [ "mold" ], "char_spans": [ { "start": [ 29 ], "end": [ 32 ] } ], "token_spans": [ { "start": [ 6 ], "end": [ 6 ] } ] }
[ "mold" ]
SQuAD
The effects of some types of mold on infection had been noticed many times over the course of history (see: History of penicillin). In 1928, Alexander Fleming noticed the same effect in a Petri dish, where a number of disease-causing bacteria were killed by a fungus of the genus Penicillium. Fleming postulated that the effect is mediated by an antibacterial compound he named penicillin, and that its antibacterial properties could be exploited for chemotherapy. He initially characterized some of its biological properties, and attempted to use a crude preparation to treat some infections, but he was unable to pursue its further development without the aid of trained chemists.
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fcddb21b6e8b41a3aa612f3d3b0cd7d4
Who noticed in a lab the antibacterial characteristics of mold?
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[ "Alexander Fleming" ]
SQuAD
The effects of some types of mold on infection had been noticed many times over the course of history (see: History of penicillin). In 1928, Alexander Fleming noticed the same effect in a Petri dish, where a number of disease-causing bacteria were killed by a fungus of the genus Penicillium. Fleming postulated that the effect is mediated by an antibacterial compound he named penicillin, and that its antibacterial properties could be exploited for chemotherapy. He initially characterized some of its biological properties, and attempted to use a crude preparation to treat some infections, but he was unable to pursue its further development without the aid of trained chemists.
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ef2ee552c6a342e1a4f3bf86f5e430a1
What mold did Fleming notice had antibacterial properties?
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[ "penicillin" ]
SQuAD
The effects of some types of mold on infection had been noticed many times over the course of history (see: History of penicillin). In 1928, Alexander Fleming noticed the same effect in a Petri dish, where a number of disease-causing bacteria were killed by a fungus of the genus Penicillium. Fleming postulated that the effect is mediated by an antibacterial compound he named penicillin, and that its antibacterial properties could be exploited for chemotherapy. He initially characterized some of its biological properties, and attempted to use a crude preparation to treat some infections, but he was unable to pursue its further development without the aid of trained chemists.
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1cc88d566372479eb28d41bcfbcec69f
What did Fleming initially think a good use would be for it?
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{ "text": [ "chemotherapy" ], "char_spans": [ { "start": [ 451 ], "end": [ 462 ] } ], "token_spans": [ { "start": [ 83 ], "end": [ 83 ] } ] }
[ "chemotherapy" ]
SQuAD
Antibacterial-resistant strains and species, sometimes referred to as "superbugs", now contribute to the emergence of diseases that were for a while well controlled. For example, emergent bacterial strains causing tuberculosis (TB) that are resistant to previously effective antibacterial treatments pose many therapeutic challenges. Every year, nearly half a million new cases of multidrug-resistant tuberculosis (MDR-TB) are estimated to occur worldwide. For example, NDM-1 is a newly identified enzyme conveying bacterial resistance to a broad range of beta-lactam antibacterials. The United Kingdom's Health Protection Agency has stated that "most isolates with NDM-1 enzyme are resistant to all standard intravenous antibiotics for treatment of severe infections."
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73ac6325a8f648aeb0ae2fcc6078f2e9
What are strains that are resistant to antibiotics called sometimes?
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{ "text": [ "superbugs" ], "char_spans": [ { "start": [ 71 ], "end": [ 79 ] } ], "token_spans": [ { "start": [ 12 ], "end": [ 12 ] } ] }
[ "superbugs" ]
SQuAD
Antibacterial-resistant strains and species, sometimes referred to as "superbugs", now contribute to the emergence of diseases that were for a while well controlled. For example, emergent bacterial strains causing tuberculosis (TB) that are resistant to previously effective antibacterial treatments pose many therapeutic challenges. Every year, nearly half a million new cases of multidrug-resistant tuberculosis (MDR-TB) are estimated to occur worldwide. For example, NDM-1 is a newly identified enzyme conveying bacterial resistance to a broad range of beta-lactam antibacterials. The United Kingdom's Health Protection Agency has stated that "most isolates with NDM-1 enzyme are resistant to all standard intravenous antibiotics for treatment of severe infections."
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1a03453461e24157828c182dba4b82c6
What was a once almost controlled disease that is coming back do to resistance?
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{ "text": [ "tuberculosis" ], "char_spans": [ { "start": [ 214 ], "end": [ 225 ] } ], "token_spans": [ { "start": [ 37 ], "end": [ 37 ] } ] }
[ "tuberculosis" ]
SQuAD
Antibacterial-resistant strains and species, sometimes referred to as "superbugs", now contribute to the emergence of diseases that were for a while well controlled. For example, emergent bacterial strains causing tuberculosis (TB) that are resistant to previously effective antibacterial treatments pose many therapeutic challenges. Every year, nearly half a million new cases of multidrug-resistant tuberculosis (MDR-TB) are estimated to occur worldwide. For example, NDM-1 is a newly identified enzyme conveying bacterial resistance to a broad range of beta-lactam antibacterials. The United Kingdom's Health Protection Agency has stated that "most isolates with NDM-1 enzyme are resistant to all standard intravenous antibiotics for treatment of severe infections."
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3bf709400d474fdaa788c4200f6d03c6
How many new infections of resistant TB are reported per year?
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{ "text": [ "half a million" ], "char_spans": [ { "start": [ 353 ], "end": [ 366 ] } ], "token_spans": [ { "start": [ 58 ], "end": [ 60 ] } ] }
[ "half a million" ]
SQuAD
Antibacterial-resistant strains and species, sometimes referred to as "superbugs", now contribute to the emergence of diseases that were for a while well controlled. For example, emergent bacterial strains causing tuberculosis (TB) that are resistant to previously effective antibacterial treatments pose many therapeutic challenges. Every year, nearly half a million new cases of multidrug-resistant tuberculosis (MDR-TB) are estimated to occur worldwide. For example, NDM-1 is a newly identified enzyme conveying bacterial resistance to a broad range of beta-lactam antibacterials. The United Kingdom's Health Protection Agency has stated that "most isolates with NDM-1 enzyme are resistant to all standard intravenous antibiotics for treatment of severe infections."
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1b71343ef56f42cca8f2d61e504832fe
What is the acronym used to describe resistant TB?
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{ "text": [ "MDR-TB" ], "char_spans": [ { "start": [ 415 ], "end": [ 420 ] } ], "token_spans": [ { "start": [ 69 ], "end": [ 71 ] } ] }
[ "MDR-TB" ]
SQuAD
Interactions between alcohol and certain antibiotics may occur and may cause side-effects and decreased effectiveness of antibiotic therapy. While moderate alcohol consumption is unlikely to interfere with many common antibiotics, there are specific types of antibiotics with which alcohol consumption may cause serious side-effects. Therefore, potential risks of side-effects and effectiveness depend on the type of antibiotic administered. Despite the lack of a categorical counterindication, the belief that alcohol and antibiotics should never be mixed is widespread.
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d21d5dbc82e0491d9781d85e7681ccc6
What is one potential issue with drinking alcohol while taking antibiotics?
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{ "text": [ "decreased effectiveness" ], "char_spans": [ { "start": [ 94 ], "end": [ 116 ] } ], "token_spans": [ { "start": [ 15 ], "end": [ 16 ] } ] }
[ "decreased effectiveness" ]
SQuAD
Interactions between alcohol and certain antibiotics may occur and may cause side-effects and decreased effectiveness of antibiotic therapy. While moderate alcohol consumption is unlikely to interfere with many common antibiotics, there are specific types of antibiotics with which alcohol consumption may cause serious side-effects. Therefore, potential risks of side-effects and effectiveness depend on the type of antibiotic administered. Despite the lack of a categorical counterindication, the belief that alcohol and antibiotics should never be mixed is widespread.
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f70af04127e440958de7536156769cc4
Do all antibiotics interact dangerously with alcohol?
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{ "text": [ "moderate alcohol consumption is unlikely to interfere with many common antibiotics" ], "char_spans": [ { "start": [ 147 ], "end": [ 228 ] } ], "token_spans": [ { "start": [ 22 ], "end": [ 32 ] } ] }
[ "moderate alcohol consumption is unlikely to interfere with many common antibiotics" ]
SQuAD
Interactions between alcohol and certain antibiotics may occur and may cause side-effects and decreased effectiveness of antibiotic therapy. While moderate alcohol consumption is unlikely to interfere with many common antibiotics, there are specific types of antibiotics with which alcohol consumption may cause serious side-effects. Therefore, potential risks of side-effects and effectiveness depend on the type of antibiotic administered. Despite the lack of a categorical counterindication, the belief that alcohol and antibiotics should never be mixed is widespread.
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fdb3aeb3989e4000ad51ff9580999796
Is it OK to drink alcohol while taking any antibiotic?
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{ "text": [ "there are specific types of antibiotics with which alcohol consumption may cause serious side-effects" ], "char_spans": [ { "start": [ 231 ], "end": [ 331 ] } ], "token_spans": [ { "start": [ 34 ], "end": [ 49 ] } ] }
[ "there are specific types of antibiotics with which alcohol consumption may cause serious side-effects" ]
SQuAD
Interactions between alcohol and certain antibiotics may occur and may cause side-effects and decreased effectiveness of antibiotic therapy. While moderate alcohol consumption is unlikely to interfere with many common antibiotics, there are specific types of antibiotics with which alcohol consumption may cause serious side-effects. Therefore, potential risks of side-effects and effectiveness depend on the type of antibiotic administered. Despite the lack of a categorical counterindication, the belief that alcohol and antibiotics should never be mixed is widespread.
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c8c5955b18424a2880d20da9452c3110
How common is the belief that alcohol and antibiotics should never be mixed?
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{ "text": [ "widespread" ], "char_spans": [ { "start": [ 560 ], "end": [ 569 ] } ], "token_spans": [ { "start": [ 88 ], "end": [ 88 ] } ] }
[ "widespread" ]
SQuAD
Interactions between alcohol and certain antibiotics may occur and may cause side-effects and decreased effectiveness of antibiotic therapy. While moderate alcohol consumption is unlikely to interfere with many common antibiotics, there are specific types of antibiotics with which alcohol consumption may cause serious side-effects. Therefore, potential risks of side-effects and effectiveness depend on the type of antibiotic administered. Despite the lack of a categorical counterindication, the belief that alcohol and antibiotics should never be mixed is widespread.
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32ad67a17f6244deb9737a2aa2253de8
What can alcohol and certain antibiotics cause?
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{ "text": [ "decreased effectiveness of antibiotic therapy" ], "char_spans": [ { "start": [ 94 ], "end": [ 138 ] } ], "token_spans": [ { "start": [ 15 ], "end": [ 19 ] } ] }
[ "decreased effectiveness of antibiotic therapy" ]
SQuAD
Interactions between alcohol and certain antibiotics may occur and may cause side-effects and decreased effectiveness of antibiotic therapy. While moderate alcohol consumption is unlikely to interfere with many common antibiotics, there are specific types of antibiotics with which alcohol consumption may cause serious side-effects. Therefore, potential risks of side-effects and effectiveness depend on the type of antibiotic administered. Despite the lack of a categorical counterindication, the belief that alcohol and antibiotics should never be mixed is widespread.
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5e3dab5559fe45d2b453d3b726b4ceb3
What is unlikely to interfere with with many common antibiotics?
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{ "text": [ "alcohol consumption" ], "char_spans": [ { "start": [ 156 ], "end": [ 174 ] } ], "token_spans": [ { "start": [ 23 ], "end": [ 24 ] } ] }
[ "alcohol consumption" ]
SQuAD
Interactions between alcohol and certain antibiotics may occur and may cause side-effects and decreased effectiveness of antibiotic therapy. While moderate alcohol consumption is unlikely to interfere with many common antibiotics, there are specific types of antibiotics with which alcohol consumption may cause serious side-effects. Therefore, potential risks of side-effects and effectiveness depend on the type of antibiotic administered. Despite the lack of a categorical counterindication, the belief that alcohol and antibiotics should never be mixed is widespread.
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ea0fe659212041f58b98f0dd3f823d20
What belief should bever be mixed widespread?
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{ "text": [ "alcohol and antibiotics" ], "char_spans": [ { "start": [ 511 ], "end": [ 533 ] } ], "token_spans": [ { "start": [ 80 ], "end": [ 82 ] } ] }
[ "alcohol and antibiotics" ]
SQuAD
Interactions between alcohol and certain antibiotics may occur and may cause side-effects and decreased effectiveness of antibiotic therapy. While moderate alcohol consumption is unlikely to interfere with many common antibiotics, there are specific types of antibiotics with which alcohol consumption may cause serious side-effects. Therefore, potential risks of side-effects and effectiveness depend on the type of antibiotic administered. Despite the lack of a categorical counterindication, the belief that alcohol and antibiotics should never be mixed is widespread.
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9453a7a803bb45e6b0b105233cbb2835
What common drug can reduce antibiotic effectiveness?
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{ "text": [ "alcohol" ], "char_spans": [ { "start": [ 21 ], "end": [ 27 ] } ], "token_spans": [ { "start": [ 2 ], "end": [ 2 ] } ] }
[ "alcohol" ]
SQuAD
Interactions between alcohol and certain antibiotics may occur and may cause side-effects and decreased effectiveness of antibiotic therapy. While moderate alcohol consumption is unlikely to interfere with many common antibiotics, there are specific types of antibiotics with which alcohol consumption may cause serious side-effects. Therefore, potential risks of side-effects and effectiveness depend on the type of antibiotic administered. Despite the lack of a categorical counterindication, the belief that alcohol and antibiotics should never be mixed is widespread.
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db4752ba50bc4b549df1aff62d6158a1
What type of antibiotic is most likely to be a problem with alcohol?
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{ "text": [ "specific types of antibiotics with which alcohol consumption may cause serious side-effects" ], "char_spans": [ { "start": [ 241 ], "end": [ 331 ] } ], "token_spans": [ { "start": [ 36 ], "end": [ 49 ] } ] }
[ "specific types of antibiotics with which alcohol consumption may cause serious side-effects" ]
SQuAD
Interactions between alcohol and certain antibiotics may occur and may cause side-effects and decreased effectiveness of antibiotic therapy. While moderate alcohol consumption is unlikely to interfere with many common antibiotics, there are specific types of antibiotics with which alcohol consumption may cause serious side-effects. Therefore, potential risks of side-effects and effectiveness depend on the type of antibiotic administered. Despite the lack of a categorical counterindication, the belief that alcohol and antibiotics should never be mixed is widespread.
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46658ac9f3ea4afdb22e50175b58d7a3
Should alcohol be used while on antibiotics?
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{ "text": [ "alcohol and antibiotics should never be mixed" ], "char_spans": [ { "start": [ 511 ], "end": [ 555 ] } ], "token_spans": [ { "start": [ 80 ], "end": [ 86 ] } ] }
[ "alcohol and antibiotics should never be mixed" ]
SQuAD
The first sulfonamide and first commercially available antibacterial, Prontosil, was developed by a research team led by Gerhard Domagk in 1932 at the Bayer Laboratories of the IG Farben conglomerate in Germany. Domagk received the 1939 Nobel Prize for Medicine for his efforts. Prontosil had a relatively broad effect against Gram-positive cocci, but not against enterobacteria. Research was stimulated apace by its success. The discovery and development of this sulfonamide drug opened the era of antibacterials.
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0c33f2f420ce40ed8b127515fb52b25b
What was the first available antibiotic?
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{ "text": [ "Prontosil" ], "char_spans": [ { "start": [ 70 ], "end": [ 78 ] } ], "token_spans": [ { "start": [ 9 ], "end": [ 9 ] } ] }
[ "Prontosil" ]
SQuAD
The first sulfonamide and first commercially available antibacterial, Prontosil, was developed by a research team led by Gerhard Domagk in 1932 at the Bayer Laboratories of the IG Farben conglomerate in Germany. Domagk received the 1939 Nobel Prize for Medicine for his efforts. Prontosil had a relatively broad effect against Gram-positive cocci, but not against enterobacteria. Research was stimulated apace by its success. The discovery and development of this sulfonamide drug opened the era of antibacterials.
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cae7afdccade491889a2087336a03517
What company developed Prontosil?
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{ "text": [ "IG Farben" ], "char_spans": [ { "start": [ 177 ], "end": [ 185 ] } ], "token_spans": [ { "start": [ 29 ], "end": [ 30 ] } ] }
[ "IG Farben" ]
SQuAD
The first sulfonamide and first commercially available antibacterial, Prontosil, was developed by a research team led by Gerhard Domagk in 1932 at the Bayer Laboratories of the IG Farben conglomerate in Germany. Domagk received the 1939 Nobel Prize for Medicine for his efforts. Prontosil had a relatively broad effect against Gram-positive cocci, but not against enterobacteria. Research was stimulated apace by its success. The discovery and development of this sulfonamide drug opened the era of antibacterials.
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c25607a835cc4d09a54b8e1a5bef4ed7
Who led the team that came up with Prontosil?
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[ "Gerhard Domagk" ]
SQuAD
The first sulfonamide and first commercially available antibacterial, Prontosil, was developed by a research team led by Gerhard Domagk in 1932 at the Bayer Laboratories of the IG Farben conglomerate in Germany. Domagk received the 1939 Nobel Prize for Medicine for his efforts. Prontosil had a relatively broad effect against Gram-positive cocci, but not against enterobacteria. Research was stimulated apace by its success. The discovery and development of this sulfonamide drug opened the era of antibacterials.
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91237ba6118f44d68f98638cd2fd3455
What prize did Domagk get for his work?
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[ "1939 Nobel Prize for Medicine" ]
SQuAD
Common forms of antibiotic misuse include excessive use of prophylactic antibiotics in travelers and failure of medical professionals to prescribe the correct dosage of antibiotics on the basis of the patient's weight and history of prior use. Other forms of misuse include failure to take the entire prescribed course of the antibiotic, incorrect dosage and administration, or failure to rest for sufficient recovery. Inappropriate antibiotic treatment, for example, is their prescription to treat viral infections such as the common cold. One study on respiratory tract infections found "physicians were more likely to prescribe antibiotics to patients who appeared to expect them". Multifactorial interventions aimed at both physicians and patients can reduce inappropriate prescription of antibiotics.
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4023a820def14c428f354a0bbef576a6
What is a way of improperly using antibiotics for those traveling?
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{ "text": [ "prophylactic antibiotics" ], "char_spans": [ { "start": [ 59 ], "end": [ 82 ] } ], "token_spans": [ { "start": [ 9 ], "end": [ 10 ] } ] }
[ "prophylactic antibiotics" ]
SQuAD
Common forms of antibiotic misuse include excessive use of prophylactic antibiotics in travelers and failure of medical professionals to prescribe the correct dosage of antibiotics on the basis of the patient's weight and history of prior use. Other forms of misuse include failure to take the entire prescribed course of the antibiotic, incorrect dosage and administration, or failure to rest for sufficient recovery. Inappropriate antibiotic treatment, for example, is their prescription to treat viral infections such as the common cold. One study on respiratory tract infections found "physicians were more likely to prescribe antibiotics to patients who appeared to expect them". Multifactorial interventions aimed at both physicians and patients can reduce inappropriate prescription of antibiotics.
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19cf4926c14f475b876ab433ce88a25c
What can happen if a doctor doesn't prescribe to a person's weight and prior use?
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{ "text": [ "failure of medical professionals to prescribe the correct dosage" ], "char_spans": [ { "start": [ 101 ], "end": [ 164 ] } ], "token_spans": [ { "start": [ 14 ], "end": [ 22 ] } ] }
[ "failure of medical professionals to prescribe the correct dosage" ]
SQuAD
Common forms of antibiotic misuse include excessive use of prophylactic antibiotics in travelers and failure of medical professionals to prescribe the correct dosage of antibiotics on the basis of the patient's weight and history of prior use. Other forms of misuse include failure to take the entire prescribed course of the antibiotic, incorrect dosage and administration, or failure to rest for sufficient recovery. Inappropriate antibiotic treatment, for example, is their prescription to treat viral infections such as the common cold. One study on respiratory tract infections found "physicians were more likely to prescribe antibiotics to patients who appeared to expect them". Multifactorial interventions aimed at both physicians and patients can reduce inappropriate prescription of antibiotics.
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8e78e24aa7914bc3a58122895fd3299e
What are 3 other common forms of bad antibiotic practices?
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{ "text": [ "failure to take the entire prescribed course of the antibiotic, incorrect dosage and administration, or failure to rest for sufficient recovery" ], "char_spans": [ { "start": [ 274 ], "end": [ 416 ] } ], "token_spans": [ { "start": [ 44 ], "end": [ 66 ] } ] }
[ "failure to take the entire prescribed course of the antibiotic, incorrect dosage and administration, or failure to rest for sufficient recovery" ]
SQuAD
Common forms of antibiotic misuse include excessive use of prophylactic antibiotics in travelers and failure of medical professionals to prescribe the correct dosage of antibiotics on the basis of the patient's weight and history of prior use. Other forms of misuse include failure to take the entire prescribed course of the antibiotic, incorrect dosage and administration, or failure to rest for sufficient recovery. Inappropriate antibiotic treatment, for example, is their prescription to treat viral infections such as the common cold. One study on respiratory tract infections found "physicians were more likely to prescribe antibiotics to patients who appeared to expect them". Multifactorial interventions aimed at both physicians and patients can reduce inappropriate prescription of antibiotics.
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9a16c9f008494f68ad66bea1c1d52c1c
What happens when a cold is treated with antibiotics?
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{ "text": [ "Inappropriate antibiotic treatment" ], "char_spans": [ { "start": [ 419 ], "end": [ 452 ] } ], "token_spans": [ { "start": [ 68 ], "end": [ 70 ] } ] }
[ "Inappropriate antibiotic treatment" ]
SQuAD
Common forms of antibiotic misuse include excessive use of prophylactic antibiotics in travelers and failure of medical professionals to prescribe the correct dosage of antibiotics on the basis of the patient's weight and history of prior use. Other forms of misuse include failure to take the entire prescribed course of the antibiotic, incorrect dosage and administration, or failure to rest for sufficient recovery. Inappropriate antibiotic treatment, for example, is their prescription to treat viral infections such as the common cold. One study on respiratory tract infections found "physicians were more likely to prescribe antibiotics to patients who appeared to expect them". Multifactorial interventions aimed at both physicians and patients can reduce inappropriate prescription of antibiotics.
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095bdc6325864f9ba4a106e976417823
What do doctors usually do when a patient seems to want antibiotics even though they may not be right?
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{ "text": [ "prescribe antibiotics" ], "char_spans": [ { "start": [ 621 ], "end": [ 641 ] } ], "token_spans": [ { "start": [ 101 ], "end": [ 102 ] } ] }
[ "prescribe antibiotics" ]
SQuAD
About 30 people have been indicted for participating in genocide or complicity in genocide during the early 1990s in Bosnia. To date, after several plea bargains and some convictions that were successfully challenged on appeal two men, Vujadin Popović and Ljubiša Beara, have been found guilty of committing genocide, Zdravko Tolimir has been found guilty of committing genocide and conspiracy to commit genocide, and two others, Radislav Krstić and Drago Nikolić, have been found guilty of aiding and abetting genocide. Three others have been found guilty of participating in genocides in Bosnia by German courts, one of whom Nikola Jorgić lost an appeal against his conviction in the European Court of Human Rights. A further eight men, former members of the Bosnian Serb security forces were found guilty of genocide by the State Court of Bosnia and Herzegovina (See List of Bosnian genocide prosecutions).
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1f812d2d0ba14078a5285487b07baf99
In the 1990s, how many people were indicted for war crimes that were officially defined as genocide?
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{ "text": [ "About 30" ], "char_spans": [ { "start": [ 0 ], "end": [ 7 ] } ], "token_spans": [ { "start": [ 0 ], "end": [ 1 ] } ] }
[ "About 30" ]
SQuAD
About 30 people have been indicted for participating in genocide or complicity in genocide during the early 1990s in Bosnia. To date, after several plea bargains and some convictions that were successfully challenged on appeal two men, Vujadin Popović and Ljubiša Beara, have been found guilty of committing genocide, Zdravko Tolimir has been found guilty of committing genocide and conspiracy to commit genocide, and two others, Radislav Krstić and Drago Nikolić, have been found guilty of aiding and abetting genocide. Three others have been found guilty of participating in genocides in Bosnia by German courts, one of whom Nikola Jorgić lost an appeal against his conviction in the European Court of Human Rights. A further eight men, former members of the Bosnian Serb security forces were found guilty of genocide by the State Court of Bosnia and Herzegovina (See List of Bosnian genocide prosecutions).
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987f20a0e5b04fc8af51be2196ec9006
Convicted perpetrators Popovic and Beara were found guilty of genocide despite what evasive action?
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{ "text": [ "several plea bargains" ], "char_spans": [ { "start": [ 140 ], "end": [ 160 ] } ], "token_spans": [ { "start": [ 25 ], "end": [ 27 ] } ] }
[ "several plea bargains" ]
SQuAD
About 30 people have been indicted for participating in genocide or complicity in genocide during the early 1990s in Bosnia. To date, after several plea bargains and some convictions that were successfully challenged on appeal two men, Vujadin Popović and Ljubiša Beara, have been found guilty of committing genocide, Zdravko Tolimir has been found guilty of committing genocide and conspiracy to commit genocide, and two others, Radislav Krstić and Drago Nikolić, have been found guilty of aiding and abetting genocide. Three others have been found guilty of participating in genocides in Bosnia by German courts, one of whom Nikola Jorgić lost an appeal against his conviction in the European Court of Human Rights. A further eight men, former members of the Bosnian Serb security forces were found guilty of genocide by the State Court of Bosnia and Herzegovina (See List of Bosnian genocide prosecutions).
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c442c65f07d5461abe562aafcebc56f0
Tolimir was found guilty of both genocide and what other charge?
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{ "text": [ "conspiracy to commit genocide" ], "char_spans": [ { "start": [ 383 ], "end": [ 411 ] } ], "token_spans": [ { "start": [ 64 ], "end": [ 67 ] } ] }
[ "conspiracy to commit genocide" ]
SQuAD
About 30 people have been indicted for participating in genocide or complicity in genocide during the early 1990s in Bosnia. To date, after several plea bargains and some convictions that were successfully challenged on appeal two men, Vujadin Popović and Ljubiša Beara, have been found guilty of committing genocide, Zdravko Tolimir has been found guilty of committing genocide and conspiracy to commit genocide, and two others, Radislav Krstić and Drago Nikolić, have been found guilty of aiding and abetting genocide. Three others have been found guilty of participating in genocides in Bosnia by German courts, one of whom Nikola Jorgić lost an appeal against his conviction in the European Court of Human Rights. A further eight men, former members of the Bosnian Serb security forces were found guilty of genocide by the State Court of Bosnia and Herzegovina (See List of Bosnian genocide prosecutions).
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80644e2e50dd40a49b1bbdc715f42744
Another charge beyond the act of genocide and for which Krstic and Nikolic were found guilty was what?
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{ "text": [ "aiding and abetting genocide" ], "char_spans": [ { "start": [ 491 ], "end": [ 518 ] } ], "token_spans": [ { "start": [ 84 ], "end": [ 87 ] } ] }
[ "aiding and abetting genocide" ]
SQuAD
About 30 people have been indicted for participating in genocide or complicity in genocide during the early 1990s in Bosnia. To date, after several plea bargains and some convictions that were successfully challenged on appeal two men, Vujadin Popović and Ljubiša Beara, have been found guilty of committing genocide, Zdravko Tolimir has been found guilty of committing genocide and conspiracy to commit genocide, and two others, Radislav Krstić and Drago Nikolić, have been found guilty of aiding and abetting genocide. Three others have been found guilty of participating in genocides in Bosnia by German courts, one of whom Nikola Jorgić lost an appeal against his conviction in the European Court of Human Rights. A further eight men, former members of the Bosnian Serb security forces were found guilty of genocide by the State Court of Bosnia and Herzegovina (See List of Bosnian genocide prosecutions).
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8f3c861371484624b60df70b0e43e703
Three others were charged with participating in genocides in Bosnia by which country's courts?
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{ "text": [ "German courts" ], "char_spans": [ { "start": [ 600 ], "end": [ 612 ] } ], "token_spans": [ { "start": [ 102 ], "end": [ 103 ] } ] }
[ "German courts" ]
SQuAD
Several organizations concerned with antimicrobial resistance are lobbying to eliminate the unnecessary use of antibiotics. The issues of misuse and overuse of antibiotics have been addressed by the formation of the US Interagency Task Force on Antimicrobial Resistance. This task force aims to actively address antimicrobial resistance, and is coordinated by the US Centers for Disease Control and Prevention, the Food and Drug Administration (FDA), and the National Institutes of Health (NIH), as well as other US agencies. An NGO campaign group is Keep Antibiotics Working. In France, an "Antibiotics are not automatic" government campaign started in 2002 and led to a marked reduction of unnecessary antibiotic prescriptions, especially in children.
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1505637ee2474e19a7ad5b3d19e032a4
What is the name of a US government agency tasked with trying to stop improper use of antibiotics?
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{ "text": [ "US Interagency Task Force on Antimicrobial Resistance" ], "char_spans": [ { "start": [ 216 ], "end": [ 268 ] } ], "token_spans": [ { "start": [ 32 ], "end": [ 38 ] } ] }
[ "US Interagency Task Force on Antimicrobial Resistance" ]
SQuAD
Several organizations concerned with antimicrobial resistance are lobbying to eliminate the unnecessary use of antibiotics. The issues of misuse and overuse of antibiotics have been addressed by the formation of the US Interagency Task Force on Antimicrobial Resistance. This task force aims to actively address antimicrobial resistance, and is coordinated by the US Centers for Disease Control and Prevention, the Food and Drug Administration (FDA), and the National Institutes of Health (NIH), as well as other US agencies. An NGO campaign group is Keep Antibiotics Working. In France, an "Antibiotics are not automatic" government campaign started in 2002 and led to a marked reduction of unnecessary antibiotic prescriptions, especially in children.
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54a395b904994573bd78d7b65c1797e4
Which agencies control this task force?
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{ "text": [ "US Centers for Disease Control and Prevention, the Food and Drug Administration (FDA), and the National Institutes of Health (NIH)" ], "char_spans": [ { "start": [ 364 ], "end": [ 493 ] } ], "token_spans": [ { "start": [ 55 ], "end": [ 80 ] } ] }
[ "US Centers for Disease Control and Prevention, the Food and Drug Administration (FDA), and the National Institutes of Health (NIH)" ]
SQuAD
Several organizations concerned with antimicrobial resistance are lobbying to eliminate the unnecessary use of antibiotics. The issues of misuse and overuse of antibiotics have been addressed by the formation of the US Interagency Task Force on Antimicrobial Resistance. This task force aims to actively address antimicrobial resistance, and is coordinated by the US Centers for Disease Control and Prevention, the Food and Drug Administration (FDA), and the National Institutes of Health (NIH), as well as other US agencies. An NGO campaign group is Keep Antibiotics Working. In France, an "Antibiotics are not automatic" government campaign started in 2002 and led to a marked reduction of unnecessary antibiotic prescriptions, especially in children.
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673802bb9824408493c3aa3f32a87aa3
When did the French start going after overuse of antibiotics?
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{ "text": [ "2002" ], "char_spans": [ { "start": [ 654 ], "end": [ 657 ] } ], "token_spans": [ { "start": [ 112 ], "end": [ 112 ] } ] }
[ "2002" ]
SQuAD
Antibacterial antibiotics are commonly classified based on their mechanism of action, chemical structure, or spectrum of activity. Most target bacterial functions or growth processes. Those that target the bacterial cell wall (penicillins and cephalosporins) or the cell membrane (polymyxins), or interfere with essential bacterial enzymes (rifamycins, lipiarmycins, quinolones, and sulfonamides) have bactericidal activities. Those that target protein synthesis (macrolides, lincosamides and tetracyclines) are usually bacteriostatic (with the exception of bactericidal aminoglycosides). Further categorization is based on their target specificity. "Narrow-spectrum" antibacterial antibiotics target specific types of bacteria, such as Gram-negative or Gram-positive bacteria, whereas broad-spectrum antibiotics affect a wide range of bacteria. Following a 40-year hiatus in discovering new classes of antibacterial compounds, four new classes of antibacterial antibiotics have been brought into clinical use in the late 2000s and early 2010s: cyclic lipopeptides (such as daptomycin), glycylcyclines (such as tigecycline), oxazolidinones (such as linezolid), and lipiarmycins (such as fidaxomicin).
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a8818b1c96264153b6f50ab8685ce56a
What do anitibiotics mostly target?
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{ "text": [ "bacterial functions or growth processes" ], "char_spans": [ { "start": [ 143 ], "end": [ 181 ] } ], "token_spans": [ { "start": [ 22 ], "end": [ 26 ] } ] }
[ "bacterial functions or growth processes" ]
SQuAD
Antibacterial antibiotics are commonly classified based on their mechanism of action, chemical structure, or spectrum of activity. Most target bacterial functions or growth processes. Those that target the bacterial cell wall (penicillins and cephalosporins) or the cell membrane (polymyxins), or interfere with essential bacterial enzymes (rifamycins, lipiarmycins, quinolones, and sulfonamides) have bactericidal activities. Those that target protein synthesis (macrolides, lincosamides and tetracyclines) are usually bacteriostatic (with the exception of bactericidal aminoglycosides). Further categorization is based on their target specificity. "Narrow-spectrum" antibacterial antibiotics target specific types of bacteria, such as Gram-negative or Gram-positive bacteria, whereas broad-spectrum antibiotics affect a wide range of bacteria. Following a 40-year hiatus in discovering new classes of antibacterial compounds, four new classes of antibacterial antibiotics have been brought into clinical use in the late 2000s and early 2010s: cyclic lipopeptides (such as daptomycin), glycylcyclines (such as tigecycline), oxazolidinones (such as linezolid), and lipiarmycins (such as fidaxomicin).
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88c79121d03446f18646faaae7606281
Which two types of antibiotics target the cell wall?
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{ "text": [ "penicillins and cephalosporins" ], "char_spans": [ { "start": [ 227 ], "end": [ 256 ] } ], "token_spans": [ { "start": [ 36 ], "end": [ 38 ] } ] }
[ "penicillins and cephalosporins" ]
SQuAD
Antibacterial antibiotics are commonly classified based on their mechanism of action, chemical structure, or spectrum of activity. Most target bacterial functions or growth processes. Those that target the bacterial cell wall (penicillins and cephalosporins) or the cell membrane (polymyxins), or interfere with essential bacterial enzymes (rifamycins, lipiarmycins, quinolones, and sulfonamides) have bactericidal activities. Those that target protein synthesis (macrolides, lincosamides and tetracyclines) are usually bacteriostatic (with the exception of bactericidal aminoglycosides). Further categorization is based on their target specificity. "Narrow-spectrum" antibacterial antibiotics target specific types of bacteria, such as Gram-negative or Gram-positive bacteria, whereas broad-spectrum antibiotics affect a wide range of bacteria. Following a 40-year hiatus in discovering new classes of antibacterial compounds, four new classes of antibacterial antibiotics have been brought into clinical use in the late 2000s and early 2010s: cyclic lipopeptides (such as daptomycin), glycylcyclines (such as tigecycline), oxazolidinones (such as linezolid), and lipiarmycins (such as fidaxomicin).
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e5f085fa35c244619f35b77380c181f5
Which type of antibiotic goes after the cell membrane?
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{ "text": [ "polymyxins" ], "char_spans": [ { "start": [ 281 ], "end": [ 290 ] } ], "token_spans": [ { "start": [ 45 ], "end": [ 45 ] } ] }
[ "polymyxins" ]
SQuAD
Antibacterial antibiotics are commonly classified based on their mechanism of action, chemical structure, or spectrum of activity. Most target bacterial functions or growth processes. Those that target the bacterial cell wall (penicillins and cephalosporins) or the cell membrane (polymyxins), or interfere with essential bacterial enzymes (rifamycins, lipiarmycins, quinolones, and sulfonamides) have bactericidal activities. Those that target protein synthesis (macrolides, lincosamides and tetracyclines) are usually bacteriostatic (with the exception of bactericidal aminoglycosides). Further categorization is based on their target specificity. "Narrow-spectrum" antibacterial antibiotics target specific types of bacteria, such as Gram-negative or Gram-positive bacteria, whereas broad-spectrum antibiotics affect a wide range of bacteria. Following a 40-year hiatus in discovering new classes of antibacterial compounds, four new classes of antibacterial antibiotics have been brought into clinical use in the late 2000s and early 2010s: cyclic lipopeptides (such as daptomycin), glycylcyclines (such as tigecycline), oxazolidinones (such as linezolid), and lipiarmycins (such as fidaxomicin).
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550404bf77364fafa4666ef3dcf2abd5
What 3 types go after protein synthesis?
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{ "text": [ "(macrolides, lincosamides and tetracyclines" ], "char_spans": [ { "start": [ 463 ], "end": [ 505 ] } ], "token_spans": [ { "start": [ 73 ], "end": [ 78 ] } ] }
[ "(macrolides, lincosamides and tetracyclines" ]
SQuAD
Antibacterial antibiotics are commonly classified based on their mechanism of action, chemical structure, or spectrum of activity. Most target bacterial functions or growth processes. Those that target the bacterial cell wall (penicillins and cephalosporins) or the cell membrane (polymyxins), or interfere with essential bacterial enzymes (rifamycins, lipiarmycins, quinolones, and sulfonamides) have bactericidal activities. Those that target protein synthesis (macrolides, lincosamides and tetracyclines) are usually bacteriostatic (with the exception of bactericidal aminoglycosides). Further categorization is based on their target specificity. "Narrow-spectrum" antibacterial antibiotics target specific types of bacteria, such as Gram-negative or Gram-positive bacteria, whereas broad-spectrum antibiotics affect a wide range of bacteria. Following a 40-year hiatus in discovering new classes of antibacterial compounds, four new classes of antibacterial antibiotics have been brought into clinical use in the late 2000s and early 2010s: cyclic lipopeptides (such as daptomycin), glycylcyclines (such as tigecycline), oxazolidinones (such as linezolid), and lipiarmycins (such as fidaxomicin).
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dc0c7dcc5f00401284740e43222b306e
Besides sprectrum of activity and chemical structure, how can antibacterial antibiotics classified?
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{ "text": [ "mechanism of action" ], "char_spans": [ { "start": [ 65 ], "end": [ 83 ] } ], "token_spans": [ { "start": [ 8 ], "end": [ 10 ] } ] }
[ "mechanism of action" ]
SQuAD
Antibacterial antibiotics are commonly classified based on their mechanism of action, chemical structure, or spectrum of activity. Most target bacterial functions or growth processes. Those that target the bacterial cell wall (penicillins and cephalosporins) or the cell membrane (polymyxins), or interfere with essential bacterial enzymes (rifamycins, lipiarmycins, quinolones, and sulfonamides) have bactericidal activities. Those that target protein synthesis (macrolides, lincosamides and tetracyclines) are usually bacteriostatic (with the exception of bactericidal aminoglycosides). Further categorization is based on their target specificity. "Narrow-spectrum" antibacterial antibiotics target specific types of bacteria, such as Gram-negative or Gram-positive bacteria, whereas broad-spectrum antibiotics affect a wide range of bacteria. Following a 40-year hiatus in discovering new classes of antibacterial compounds, four new classes of antibacterial antibiotics have been brought into clinical use in the late 2000s and early 2010s: cyclic lipopeptides (such as daptomycin), glycylcyclines (such as tigecycline), oxazolidinones (such as linezolid), and lipiarmycins (such as fidaxomicin).
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748e92d37945436eb364ae46c70cf8e3
What is another name used for bacterial cell wall?
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{ "text": [ "penicillins and cephalosporins" ], "char_spans": [ { "start": [ 227 ], "end": [ 256 ] } ], "token_spans": [ { "start": [ 36 ], "end": [ 38 ] } ] }
[ "penicillins and cephalosporins" ]
SQuAD
Antibacterial antibiotics are commonly classified based on their mechanism of action, chemical structure, or spectrum of activity. Most target bacterial functions or growth processes. Those that target the bacterial cell wall (penicillins and cephalosporins) or the cell membrane (polymyxins), or interfere with essential bacterial enzymes (rifamycins, lipiarmycins, quinolones, and sulfonamides) have bactericidal activities. Those that target protein synthesis (macrolides, lincosamides and tetracyclines) are usually bacteriostatic (with the exception of bactericidal aminoglycosides). Further categorization is based on their target specificity. "Narrow-spectrum" antibacterial antibiotics target specific types of bacteria, such as Gram-negative or Gram-positive bacteria, whereas broad-spectrum antibiotics affect a wide range of bacteria. Following a 40-year hiatus in discovering new classes of antibacterial compounds, four new classes of antibacterial antibiotics have been brought into clinical use in the late 2000s and early 2010s: cyclic lipopeptides (such as daptomycin), glycylcyclines (such as tigecycline), oxazolidinones (such as linezolid), and lipiarmycins (such as fidaxomicin).
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dc194b126f3f482b9ec99f0e3f60634e
whats another word for cell membrane?
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{ "text": [ "polymyxins" ], "char_spans": [ { "start": [ 281 ], "end": [ 290 ] } ], "token_spans": [ { "start": [ 45 ], "end": [ 45 ] } ] }
[ "polymyxins" ]
SQuAD
Antibacterial antibiotics are commonly classified based on their mechanism of action, chemical structure, or spectrum of activity. Most target bacterial functions or growth processes. Those that target the bacterial cell wall (penicillins and cephalosporins) or the cell membrane (polymyxins), or interfere with essential bacterial enzymes (rifamycins, lipiarmycins, quinolones, and sulfonamides) have bactericidal activities. Those that target protein synthesis (macrolides, lincosamides and tetracyclines) are usually bacteriostatic (with the exception of bactericidal aminoglycosides). Further categorization is based on their target specificity. "Narrow-spectrum" antibacterial antibiotics target specific types of bacteria, such as Gram-negative or Gram-positive bacteria, whereas broad-spectrum antibiotics affect a wide range of bacteria. Following a 40-year hiatus in discovering new classes of antibacterial compounds, four new classes of antibacterial antibiotics have been brought into clinical use in the late 2000s and early 2010s: cyclic lipopeptides (such as daptomycin), glycylcyclines (such as tigecycline), oxazolidinones (such as linezolid), and lipiarmycins (such as fidaxomicin).
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26f3c5105ee44aaeb150ae1221347356
How many new classes of antibacterial antibiotics was introduced in the late 2000's/
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{ "text": [ "four" ], "char_spans": [ { "start": [ 928 ], "end": [ 931 ] } ], "token_spans": [ { "start": [ 149 ], "end": [ 149 ] } ] }
[ "four" ]
SQuAD
Antibacterial antibiotics are commonly classified based on their mechanism of action, chemical structure, or spectrum of activity. Most target bacterial functions or growth processes. Those that target the bacterial cell wall (penicillins and cephalosporins) or the cell membrane (polymyxins), or interfere with essential bacterial enzymes (rifamycins, lipiarmycins, quinolones, and sulfonamides) have bactericidal activities. Those that target protein synthesis (macrolides, lincosamides and tetracyclines) are usually bacteriostatic (with the exception of bactericidal aminoglycosides). Further categorization is based on their target specificity. "Narrow-spectrum" antibacterial antibiotics target specific types of bacteria, such as Gram-negative or Gram-positive bacteria, whereas broad-spectrum antibiotics affect a wide range of bacteria. Following a 40-year hiatus in discovering new classes of antibacterial compounds, four new classes of antibacterial antibiotics have been brought into clinical use in the late 2000s and early 2010s: cyclic lipopeptides (such as daptomycin), glycylcyclines (such as tigecycline), oxazolidinones (such as linezolid), and lipiarmycins (such as fidaxomicin).
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ec800b659f0846adac47f7e7fefdc921
What three ways are antibiotics classified?
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[ "mechanism of action, chemical structure, or spectrum of activity" ]
SQuAD
The emergence of antibiotic resistance has prompted restrictions on their use in the UK in 1970 (Swann report 1969), and the EU has banned the use of antibiotics as growth-promotional agents since 2003. Moreover, several organizations (e.g., The American Society for Microbiology (ASM), American Public Health Association (APHA) and the American Medical Association (AMA)) have called for restrictions on antibiotic use in food animal production and an end to all nontherapeutic uses.[citation needed] However, commonly there are delays in regulatory and legislative actions to limit the use of antibiotics, attributable partly to resistance against such regulation by industries using or selling antibiotics, and to the time required for research to test causal links between their use and resistance to them. Two federal bills (S.742 and H.R. 2562) aimed at phasing out nontherapeutic use of antibiotics in US food animals were proposed, but have not passed. These bills were endorsed by public health and medical organizations, including the American Holistic Nurses' Association, the American Medical Association, and the American Public Health Association (APHA).
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604e8d470e6d41408d7881c5d7b36425
When did the EU ban antibiotics for speeding up growth?
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[ "2003" ]
SQuAD
The emergence of antibiotic resistance has prompted restrictions on their use in the UK in 1970 (Swann report 1969), and the EU has banned the use of antibiotics as growth-promotional agents since 2003. Moreover, several organizations (e.g., The American Society for Microbiology (ASM), American Public Health Association (APHA) and the American Medical Association (AMA)) have called for restrictions on antibiotic use in food animal production and an end to all nontherapeutic uses.[citation needed] However, commonly there are delays in regulatory and legislative actions to limit the use of antibiotics, attributable partly to resistance against such regulation by industries using or selling antibiotics, and to the time required for research to test causal links between their use and resistance to them. Two federal bills (S.742 and H.R. 2562) aimed at phasing out nontherapeutic use of antibiotics in US food animals were proposed, but have not passed. These bills were endorsed by public health and medical organizations, including the American Holistic Nurses' Association, the American Medical Association, and the American Public Health Association (APHA).
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963996cdb7194012a8dd9278c9332822
What report caused the UK to worry about resistance?
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{ "text": [ "Swann report 1969" ], "char_spans": [ { "start": [ 97 ], "end": [ 113 ] } ], "token_spans": [ { "start": [ 17 ], "end": [ 19 ] } ] }
[ "Swann report 1969" ]
SQuAD
The emergence of antibiotic resistance has prompted restrictions on their use in the UK in 1970 (Swann report 1969), and the EU has banned the use of antibiotics as growth-promotional agents since 2003. Moreover, several organizations (e.g., The American Society for Microbiology (ASM), American Public Health Association (APHA) and the American Medical Association (AMA)) have called for restrictions on antibiotic use in food animal production and an end to all nontherapeutic uses.[citation needed] However, commonly there are delays in regulatory and legislative actions to limit the use of antibiotics, attributable partly to resistance against such regulation by industries using or selling antibiotics, and to the time required for research to test causal links between their use and resistance to them. Two federal bills (S.742 and H.R. 2562) aimed at phasing out nontherapeutic use of antibiotics in US food animals were proposed, but have not passed. These bills were endorsed by public health and medical organizations, including the American Holistic Nurses' Association, the American Medical Association, and the American Public Health Association (APHA).
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fe4febfe24af40cfb0abec956b8a203c
What 3 US organizations have called for the banning of antibiotics in the production of food animals?
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{ "text": [ "American Society for Microbiology (ASM), American Public Health Association (APHA) and the American Medical Association (AMA)" ], "char_spans": [ { "start": [ 246 ], "end": [ 370 ] } ], "token_spans": [ { "start": [ 47 ], "end": [ 69 ] } ] }
[ "American Society for Microbiology (ASM), American Public Health Association (APHA) and the American Medical Association (AMA)" ]
SQuAD
The emergence of antibiotic resistance has prompted restrictions on their use in the UK in 1970 (Swann report 1969), and the EU has banned the use of antibiotics as growth-promotional agents since 2003. Moreover, several organizations (e.g., The American Society for Microbiology (ASM), American Public Health Association (APHA) and the American Medical Association (AMA)) have called for restrictions on antibiotic use in food animal production and an end to all nontherapeutic uses.[citation needed] However, commonly there are delays in regulatory and legislative actions to limit the use of antibiotics, attributable partly to resistance against such regulation by industries using or selling antibiotics, and to the time required for research to test causal links between their use and resistance to them. Two federal bills (S.742 and H.R. 2562) aimed at phasing out nontherapeutic use of antibiotics in US food animals were proposed, but have not passed. These bills were endorsed by public health and medical organizations, including the American Holistic Nurses' Association, the American Medical Association, and the American Public Health Association (APHA).
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1f061522330148178134328621424358
Name two US bills that want to ban antibiotics in food production?
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[ "S.742 and H.R. 2562" ]
SQuAD
The emergence of antibiotic resistance has prompted restrictions on their use in the UK in 1970 (Swann report 1969), and the EU has banned the use of antibiotics as growth-promotional agents since 2003. Moreover, several organizations (e.g., The American Society for Microbiology (ASM), American Public Health Association (APHA) and the American Medical Association (AMA)) have called for restrictions on antibiotic use in food animal production and an end to all nontherapeutic uses.[citation needed] However, commonly there are delays in regulatory and legislative actions to limit the use of antibiotics, attributable partly to resistance against such regulation by industries using or selling antibiotics, and to the time required for research to test causal links between their use and resistance to them. Two federal bills (S.742 and H.R. 2562) aimed at phasing out nontherapeutic use of antibiotics in US food animals were proposed, but have not passed. These bills were endorsed by public health and medical organizations, including the American Holistic Nurses' Association, the American Medical Association, and the American Public Health Association (APHA).
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What 3 medical associations supported the bills?
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[ "American Holistic Nurses' Association, the American Medical Association, and the American Public Health Association (APHA)" ]
SQuAD
In 1939, coinciding with the start of World War II, Rene Dubos reported the discovery of the first naturally derived antibiotic, tyrothricin, a compound of 20% gramicidin and 80% tyrocidine, from B. brevis. It was one of the first commercially manufactured antibiotics universally and was very effective in treating wounds and ulcers during World War II. Gramicidin, however, could not be used systemically because of toxicity. Tyrocidine also proved too toxic for systemic usage. Research results obtained during that period were not shared between the Axis and the Allied powers during the war.
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What was the first antibiotic developed from nature?
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[ "tyrothricin" ]
SQuAD
In 1939, coinciding with the start of World War II, Rene Dubos reported the discovery of the first naturally derived antibiotic, tyrothricin, a compound of 20% gramicidin and 80% tyrocidine, from B. brevis. It was one of the first commercially manufactured antibiotics universally and was very effective in treating wounds and ulcers during World War II. Gramicidin, however, could not be used systemically because of toxicity. Tyrocidine also proved too toxic for systemic usage. Research results obtained during that period were not shared between the Axis and the Allied powers during the war.
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b112d55853294e17916e4bc86fda07cd
When was tyrothricin created?
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[ "1939" ]
SQuAD
In 1939, coinciding with the start of World War II, Rene Dubos reported the discovery of the first naturally derived antibiotic, tyrothricin, a compound of 20% gramicidin and 80% tyrocidine, from B. brevis. It was one of the first commercially manufactured antibiotics universally and was very effective in treating wounds and ulcers during World War II. Gramicidin, however, could not be used systemically because of toxicity. Tyrocidine also proved too toxic for systemic usage. Research results obtained during that period were not shared between the Axis and the Allied powers during the war.
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4d6d5f2825224052a59809a189ac7f57
What also happened in 1939 besides tyrothricin?
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{ "text": [ "start of World War II," ], "char_spans": [ { "start": [ 29 ], "end": [ 50 ] } ], "token_spans": [ { "start": [ 6 ], "end": [ 11 ] } ] }
[ "start of World War II," ]
SQuAD
In 1939, coinciding with the start of World War II, Rene Dubos reported the discovery of the first naturally derived antibiotic, tyrothricin, a compound of 20% gramicidin and 80% tyrocidine, from B. brevis. It was one of the first commercially manufactured antibiotics universally and was very effective in treating wounds and ulcers during World War II. Gramicidin, however, could not be used systemically because of toxicity. Tyrocidine also proved too toxic for systemic usage. Research results obtained during that period were not shared between the Axis and the Allied powers during the war.
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Who discovered tyrothricin?
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[ "Rene Dubos" ]
SQuAD
In 1939, coinciding with the start of World War II, Rene Dubos reported the discovery of the first naturally derived antibiotic, tyrothricin, a compound of 20% gramicidin and 80% tyrocidine, from B. brevis. It was one of the first commercially manufactured antibiotics universally and was very effective in treating wounds and ulcers during World War II. Gramicidin, however, could not be used systemically because of toxicity. Tyrocidine also proved too toxic for systemic usage. Research results obtained during that period were not shared between the Axis and the Allied powers during the war.
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What was tyrothricin used for during the war?
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{ "text": [ "wounds and ulcers" ], "char_spans": [ { "start": [ 316 ], "end": [ 332 ] } ], "token_spans": [ { "start": [ 57 ], "end": [ 59 ] } ] }
[ "wounds and ulcers" ]
SQuAD
Vaccines rely on immune modulation or augmentation. Vaccination either excites or reinforces the immune competence of a host to ward off infection, leading to the activation of macrophages, the production of antibodies, inflammation, and other classic immune reactions. Antibacterial vaccines have been responsible for a drastic reduction in global bacterial diseases. Vaccines made from attenuated whole cells or lysates have been replaced largely by less reactogenic, cell-free vaccines consisting of purified components, including capsular polysaccharides and their conjugates, to protein carriers, as well as inactivated toxins (toxoids) and proteins.
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What do vaccines need to work?
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{ "text": [ "immune modulation or augmentation" ], "char_spans": [ { "start": [ 17 ], "end": [ 49 ] } ], "token_spans": [ { "start": [ 3 ], "end": [ 6 ] } ] }
[ "immune modulation or augmentation" ]
SQuAD
Vaccines rely on immune modulation or augmentation. Vaccination either excites or reinforces the immune competence of a host to ward off infection, leading to the activation of macrophages, the production of antibodies, inflammation, and other classic immune reactions. Antibacterial vaccines have been responsible for a drastic reduction in global bacterial diseases. Vaccines made from attenuated whole cells or lysates have been replaced largely by less reactogenic, cell-free vaccines consisting of purified components, including capsular polysaccharides and their conjugates, to protein carriers, as well as inactivated toxins (toxoids) and proteins.
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What type of vaccines have saved millions of lives?
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{ "text": [ "Antibacterial vaccines" ], "char_spans": [ { "start": [ 270 ], "end": [ 291 ] } ], "token_spans": [ { "start": [ 44 ], "end": [ 45 ] } ] }
[ "Antibacterial vaccines" ]
SQuAD
Vaccines rely on immune modulation or augmentation. Vaccination either excites or reinforces the immune competence of a host to ward off infection, leading to the activation of macrophages, the production of antibodies, inflammation, and other classic immune reactions. Antibacterial vaccines have been responsible for a drastic reduction in global bacterial diseases. Vaccines made from attenuated whole cells or lysates have been replaced largely by less reactogenic, cell-free vaccines consisting of purified components, including capsular polysaccharides and their conjugates, to protein carriers, as well as inactivated toxins (toxoids) and proteins.
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97cf39292977415ca2e4f601a6ec8ed2
What types of vaccines have been phased out?
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{ "text": [ "Vaccines made from attenuated whole cells or lysates" ], "char_spans": [ { "start": [ 369 ], "end": [ 420 ] } ], "token_spans": [ { "start": [ 58 ], "end": [ 65 ] } ] }
[ "Vaccines made from attenuated whole cells or lysates" ]
SQuAD
In Paris, Chopin encountered artists and other distinguished figures, and found many opportunities to exercise his talents and achieve celebrity. During his years in Paris he was to become acquainted with, among many others, Hector Berlioz, Franz Liszt, Ferdinand Hiller, Heinrich Heine, Eugène Delacroix, and Alfred de Vigny. Chopin was also acquainted with the poet Adam Mickiewicz, principal of the Polish Literary Society, some of whose verses he set as songs.
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84c8396e32a4404082afbae57f6fd573
In what city did Frédéric achieve celebrity status?
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[ "Paris" ]
SQuAD
In Paris, Chopin encountered artists and other distinguished figures, and found many opportunities to exercise his talents and achieve celebrity. During his years in Paris he was to become acquainted with, among many others, Hector Berlioz, Franz Liszt, Ferdinand Hiller, Heinrich Heine, Eugène Delacroix, and Alfred de Vigny. Chopin was also acquainted with the poet Adam Mickiewicz, principal of the Polish Literary Society, some of whose verses he set as songs.
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d70a06ce3d5c4be9b2b966a4f179c859
Who was the principal of the Polish Literary Society that Frédéric became acquainted with?
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{ "text": [ "Adam Mickiewicz" ], "char_spans": [ { "start": [ 368 ], "end": [ 382 ] } ], "token_spans": [ { "start": [ 66 ], "end": [ 67 ] } ] }
[ "Adam Mickiewicz" ]