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4,600
Sb6_342 was mapped to chromosome 7 [44] whereas Sb5_236 was mapped to chromosome 3 [41, 44], both of which were confirmed in the present study through BLAST searching of the sorghum genome.
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4,601
Data drawn from Jablensky and Cole (1997). In order of increasing latitude the cities were Cali, Colombia; Ibadan, Nigeria; Agra, India; Honolulu, USA; Chandigarh, India (rural and urban); Nagasaki, Japan; Rochester, USA; Prague, Czech Rep.
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4,602
Transient transfection of HeLa cells using Lipofectamine 2000 (Invitrogen) and infection of primary HFFs with HCMV laboratory strain AD169 or clinical isolates R3 (Iso 3) and R4 (Iso 4) was performed as described elsewhere (Marschall et al., 2000; Efferth et al., 2002; Herget et al., 2004; Schregel et al. 2007).
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method
4,603
The reported normal range for GFAP (95% of all healthy subjects) is\0.3 ng/ml (Missler et al. 1999) and for NSE B 13 ng/ml (Bremnes et al. 2003).
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4,604
We previously reported a sharp decline in the quantity and molecular integrity of ptDNA when maize seedlings developed in the light but not under dark conditions (Oldenburg and Bendich 2004; Oldenburg et al. 2006; Zheng et al. 2011).
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4,605
[6,7] This is a challenge because of the long distances to travel for consultations, and thus patients are unlikely to come back for treatment for something like OSSN unless it is in its advanced stages significantly impacting their quality of life, at which point early interventions are no longer possible.[6,8] A 2010 study in Tanzania showed that 40% of operated suspected OSSN cases were managed outside of major hospitals where better facilities and quality of care was available, because of difficulty of traveling to and accessing these centers.
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4,606
Although all three species are relevant for primate conservation plans, Udzungwa red colobus is of particular interest; it is found only in the remaining forest fragments within and around the Udzungwa Mountains, it is listed as endangered (IUCN 2013), and is very sensitive to environmental changes and hunting (Marshall 2007; Marshall et al. 2010; Rovero and Struhsaker 2007; Rovero et al. 2012; Struhsaker 2010).
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4,607
For nocodazole treatment of embryos, L4 worms were grown on perm-1(RNAi) feeding plates at 20°C for 16-18 hr, then dissected in an open imaging chamber filled with osmotic support medium (Carvalho et al., 2011; Wueseke et al., 2016) and 20 µg/ml nocodazole (Sigma).
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method
4,608
Although international guidelines are not available on the topic, in our routine experience sampling of different tumor areas by core biopsy (three biopsies on average) is helpful to define the precise nature of the lesion, the different tumor histological types present in the mass, and the heterogeneity in the expression of predictive markers (Marchio and Sapino, 2011).
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4,609
A simulated annealing-based heuristic approach has been developed to solve the NP-complete problem in a computationally efficient manner [53].
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4,610
[45 ] find that in EC stellate cells the frequency could either increase or decrease with depolarization, whereas Chapman and Lacaille [44] find that there is a frequency increase with depolarization for CA1 hippocampal interneurons.
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4,611
The effort to develop new treatments for ALS has led to repeated failure since the demonstration that riluzole extended survival.[3] Despite initially encouraging results from a Phase II trial, which suggested beneficial effects on ALSFRS-R and survival,[27] the recent negative results of the dexpramipexole Phase III study is yet another disappointing example.
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4,612
This finding corresponds well with the results of Askaer et al. (2011); Couwenberg et al. (2011); Schäfer et al. (2012) and Audet et al. (2013b), who all reported negligible CH4 emissions when GWL was 20–30 cm below the soil surface, which is attributed to a restricted methane production zone and…
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4,613
For each subject, whole brain fiber tracking (an interpolated streamline propagation algorithm) was performed in the DTI native space using TrackVis (Schmahmann et al. 2007).
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method
4,614
Several models for provenance have emerged to tackle this vision, including Provenir [20, 21], the Provenance Vocabulary [22], PASOA [23], OPMV [24], PML [25] and the Open Provenance Model [26].
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4,615
CSE [prepared by dissolving the collected smoke particulates in dimethyl sulfoxide (DMSO)] or cytokine mix (TNF- and IFN- ) induced MMP-12 mRNA in HBEC (177, 178).
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4,616
Multiple origins of geometrid female flightlessness (even within a single subfamily) were shown by molecular phylogenetic studies, based on the premise of unlikely events of reversal (Snäll et al. 2007; Wahlberg et al. 2010).
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4,617
Temporal food scarcity, for example, is likely more common on islands (especially on small ones; see Van Damme 1999; Cooper and Vitt 2002 and references therein) and might force insular lizards towards frugivory or herbivory in general.
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4,618
, 2009; Dedrick et al., 2010) have received a great deal of attention. Xing and Detert (2010) examined the case of the iPhone and found that China just contributed only 3.6% of $2.0 billion export to the US, the rest was simply a transfer from Germany, Japan, Korea, the US, and other countries. These studies rely on “tear down” analyses that assign the value of individual components to source companies and their countries. These firm- and product-based case studies can provide intuitive images of GVCs in terms of the activities of multinational enterprises. However, when we examine the Chinese economy’s role in global production networks as a whole, its share of total value added through the export of final products to the United States was actually about 75% in 2005 (Meng et al., 2011). This indicates that the “tear down” case studies focus on only the supply chain of a specific firm and particular products, and are clearly not representative of the broader role of China’s domestic production networks and inter-industrial linkages in the whole value creation process. Other work on this topic shows that domestic value added can vary substantially between different economic sectors (see Koopman et al. (forthcoming 2013), Erumban et al. (2011), Stehrer (2012), and OECD-WTO (2013).
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4,619
In line with these results, the present study showed that n-3 PUFA supplementation up-regulated the expres- sion of PPARa, CPT1, p-AMPK, and AMPK in liver and/ or skeletal muscle of OVX rats.
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4,620
Specific formins mediate formation of contractile stress fibers (SFs), transmembrane actin-associated (TAN) lines on the dorsal cell surface that position the nucleus, filopodia at the leading edge, isotropic cortical actin networks, and actin important for mitochondrial fission (Skau and Waterman 2015; Campellone and Welch 2010).
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4,621
[33] In order to enrich the CIS group for patients at highest risk of progressing to MS, [34] CIS patients with at least one T2 hyperintensity typical of demyelination on conventional brain MRI were considered to be ‘‘high-risk’’ and were included for analysis.
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4,622
The T-STAR antibody (HPA000500) was developed as previously described and validated using IHC on different tissues within the Human Protein Atlas (HPA)-project [9] (Atlas Antibodies, Stockholm, Sweden).
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method
4,623
These assumptions are related to a weaker form of the second-order sufficient conditions [16, 6], which does not imply the existence of a locally convex augmented Lagrangian as is the case in [5, 9, 15, 14, 26, 30, 31].
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4,624
…scaffold protein DISC1 (Millar et al., 2000), which interacts with other proteins involved in neuronal migration, cell-signalling and -proliferation (Ishizuka et al., 2006), cytosceletal and synaptic function, neurite extension (Murdoch et al., 2007) and neuronal development (Kamiya et al., 2005).
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4,625
…important disadvantages, such as Golgi tendon organ and myotatic reflex inhibition, which can lead to an increased injury risk (Jubeau et al, 2006; Requena et al., 2005), and some difficulties in obtaining improvements in agonist and antagonist muscle coordination (Holcomb, 2005; Paillard, 2008).
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4,626
They form the crux of many DSMS applications, such as object tracking [19], video correlation [18], and news item matching [13].
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4,627
DGC via S-SCAM and SynArfGEF binding to dystrophin (Sumita et al. 2007; Fukaya et al. 2011), NL2 does not appear to play a role in synapse formation, in striking contrast with our results that a-dystroglycan is required for formation and maintenance of synapses from CCK-basket cells (Früh et al.
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4,628
Recently, the flgII-28 region in Pst flagellin specifically recognized by Solanaceae species and a new domain other than elf18 in EF-Tu recognized by rice were reported as new MAMPs (Cai et al., 2011; Clarke et al., 2013; Furukawa et al., 2013).
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4,629
Stimuli were 12 3 12 arrays presented in the centre of the white screen, with each array position occupied by either a blue or red alien cartoon character (‘‘greeblie’’) measuring approximately 8 mm wide and 9 mm high (see Figure 3, Lie & Alsop, 2009).
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4,630
A Phylogenetic Approach (9), and were provided with limited supplementary and/or review reading from Bioinformatics: A Practical Guide to the Analysis of Genes & Proteins (1), Bioinformatics for Dummies (5), Biology (4), and Brock Biology of Microorganisms (7).
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4,631
General discussion The past decade has seen the advent of a number of actionbased models of visual selective attention (Rizzolatti et al.1994; Tipper et al.1992; Welsh and Elliott 2004a).
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4,632
Phosphorylation of C/EBPβ inhibits expression of IL-17 downstream target genes, thus GSK3β negatively regulates IL-17 signaling through phosphorylation of C/EBPβ (20).
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4,633
We have also implemented a new patch for NetMate to collect the feature sets proposed in [3] and [5], which we will refer to as the Extended feature sets (Table 2).
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4,634
[77] reported that the incidence of gastric adenocarcinomas in Wistar rats given MNNG (50llg/ml) for 25 weeks followed by a low protein diet (5% casein) was 63%, whereas those given a higher protein diet (10% and 25% casein) were 15% and 18%, respectively.
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method
4,635
In recent years there has been a lot of interest in the definition of so-called weakly-relational numeric domains, whose complexity and precision are in between the (non-relational) abstract domain of intervals [9] and the (relational) abstract domain of convex polyhedra [10].
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4,636
Untreated infection results in the progressive depletion of the helper T-cell population, and the resulting immunodeficiency leads to death by opportunistic infection (Thompson et al. (2012)).
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4,637
The authors’ approach to hepatic resection for CRLM has been described previously.(8,20,21) All operations included in this study were performed with therapeutic intent, where treatment of all disease while leaving behind an adequate liver remnant was believed to be technically feasible.
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4,638
As previously shown for other biological networks (Barabási et al 2011), the degree distribution of the IEMi followed a power law, indicating a scale-free biological network with many proteins with low degree and few proteins with high degree (Fig.
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4,639
This research also indicates that, as Eisen and Moore [14] feared, there is the possibility of human population characteristics confounding the relationship between climate and mosquito presence.
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4,640
Such MAC algorithms and universal hash functions include UMAC [9], MMH [17], NMH [17], Square Hash [15], Poly1305-AES [6], CWC [25], GCM/GMAC [30, 31], and a recent polynomial variant by Bernstein [7].
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4,641
In line with previous results (3, 19, 20, 30), we found that during muscle contraction ERK1/2 phosphorylation was increased and was not affected by CaMKII inhibition.
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4,642
While the prevalence of hyperechogenicity is only *9 % in healthy adults (Berg et al. 1999a), the statistical power was appropriate for detecting significant differences between groups (e.g. grip force group-by-trial interaction = 0.87).
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4,643
As a consequence, exposure to nicotine during adolescence compromises normal PFC development (Counotte et al., 2011b; Goriounova and Mansvelder, 2012a).
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4,644
Both ATRX mutation (1) and MSI (21) are seen more frequently in younger patients with GBM.
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4,645
In contrast to earlier reports placingMalassezia among the Exobasidiomycetes [17] or Ustilaginomycetes [25], our analysis suggests that it may be an isolated group (namely the class Malasseziomycetes) in the subphylum of Ustilaginomycotina, in agreement with Wang et al [16].
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4,646
A second flavonol-type compound that was identified by comparison to the proposed fragmentation pattern in the literature, was kaempferol-3-O-glucoside (Schmidt et al., 2010) (41, M = 448.
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4,647
…perceptions of the role of arts in health and well-being yielded only 54 relevant studies, four of which focused specifically on the salience of aesthetic and cultural issues in their lives (Caspari et al. 2011, Moss et al. 2012, O’Sullivan & Chard 2010, Reynolds & Prior 2011, Wikstrom 2004).
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4,648
These include four reports on the survival of Jewish women with BRCA1/2 mutations diagnosed with EOC.(8,10,11,13) It has been postulated that this improved outcome may be the result of increased platinum sensitivity in BRCApositive tumors.
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4,649
However, it has to be noted that our study did not investigate other important disturbance aspects such as the interactive effects of disturbance frequency and spatial extent, which can influence competitive outcomes and thus species diversity (Miller et al. 2012a).
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4,650
Thus, the specificity of topographic characteristics of the dynamics of EEG coherence supports the previous [1, 2] evidence that MM and RM are states determined by cognitive specific types of attention.
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4,651
As reproduction appears the key trait maximizing fitness (Viblanc et al. 2010), we predicted that greater allocations into reproduction should be made in the presence of greater number of kin, either due to a positive effect of kin numbers on energy income, or if more female kin provide a safer environment for raising the young.
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4,652
The topology optimization of the flow component is introduced into the model by adding a Brinkman term (Brinkman, 1947) to the Navier-Stokes equation.
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method
4,653
…P450 1A5 was immunoinhibited (reflecting the contribution of 3A37 only), TLMs produced exo-AFBO and AFQ1, best fitted by sigmoidal kinetic Hill plot in agreement with the previous reports for AFB1 metabolism catalyzed by human P450 3A4 (Ueng et al., 1995) and turkey P450 3A37 (Rawal et al., 2010b).
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4,654
Blots were probed with primary and fluorescent secondary Abs as described [10].
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method
4,655
Bond graphs are a domain-independent notion of physical systems modeling, where the physical processes are directly represented as vertices in a directed graph (Breedveld, 1984; Thoma, 1989; Cellier 1991) and the edges represent the ideal exchange of energy between the vertices.
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4,656
…squirrels in the low elevation-meadow and alpinemeadow habitats in 2008–10, and the simultaneous extirpation of ground squirrels from the boreal forest since 1998 (Donker and Krebs 2011), provides supportive evidence that the boreal forest is functioning as sink habitat for arctic ground squirrels.
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4,657
REMI mutagenesis (Kuspa & Loomis, 1992) of Ax2 cells used pBRS1 vector and DpnII introduced by electroporation.
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method
4,658
…different from those measured from both hWT (n = 62) and hMT neurons both from coronal and parasagittal slices (n = 76, 27, respectively) (Table 1), and did not differ from those previously described for mouse MSN in tissue slice preparations (Goldberg et al., 2005; Bonsi et al., 2008).
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4,659
Rather, our results are concordant with those of Rowe et al. (2009) and Fischer and Paukert (2008) where the explanatory power of local-scale environmental characteristics exceeded the large-scale influences on fish assemblage structure in relatively homogenous (i.e. agriculturally dominated)…
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4,660
Furthermore, the hospital anxiety and depression scale (HAD) (Snaith and Zigmond, 1986) and the IBS special scale for quality of life (QOL) (IBSQOL) (Drossman et al., 2000) were used.
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method
4,661
…said, however, that M. senhousia, as well as other alien species, might initially increase local species number; however, through strong direct or indirect effects, it might lead to reduced species richness of native species, and a decrease in the abundance of remaining species (Ruiz et al., 1997).
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4,662
Phase II We compared the TC-1 results with 6 other machine learning algorithms, as available in a benchmark toolkit named Weka.(4) Weka runs were repeated with various feature set sizes, including a small (50) and large feature set (5000).
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4,663
In some countries, such as Israel (Lavi and Sussman, 2001), Australia (Kumar, Webber and Perry, 2009), the United States (Strauss and Wohar, 2004), and Malaysia (Goh and Wong, 2010), the empirical evidence generally supports a long-term co-integrating link between labor productivity and
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4,664
We tested MAP [42], CLUSTAL-W [43], MAFFT [44] and PRANK [45] (see Methods).
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4,665
…2010) Lack of HPWS/HRM in Victorian health care organisations Victorian state public health care organisations report limited HRM/HPWS components (Leggat et al., 2008) Victorian state public hospitals report fewer aspects of HPWS then community health services (Leggat et al., 2006) CEOs, HR…
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4,666
Models on working memory have to a large extent been focused on PFC (Amit & Brunel, 1997; Durstewitz, Seamans, & Sejnowski, 2000; Lisman & Idiart, 1995), but there is also some modeling work on IT, e.g. Jensen, Idiart, and Lisman (1996), Sohal and Hasselmo (2000).
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4,667
…no impairment of manual motor control has been demonstrated convincingly during simple motor tasks, e.g., paced fist clench (Pascual Leone et al., 1998), finger tapping (Wassermann et al., 1996; Chen et al., 1997), peak force, and acceleration during finger pinch (Muellbacher et al., 2000).
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4,668
Since TLRs are known to play a major role in the inflammatory response to sepsis [25,26,27], we sought to determine if SRA interacts with TLRs during CLP
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background
4,669
Among several endogenous lipophilic molecules known to activate CBRs, the best characterized are N-arachidonoylethanolamine (anandamide, AEA) and 2-arachidonoylglycerol (2-AG), which are known to modulate synaptic transmission throughout the brain (Zogopoulos et al., 2013).
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background
4,670
We corroborate results from Suzuki and Meekers (2008) that show that media exposure is related to a reduced risk of circumcision.
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result
4,671
A recent review by Kazan et al depicted current advancements in FHB pathogenomics and host resistance [26].
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method
4,672
In addition, it has been noted that markets for LKS could increase the value of forests, contributing to the viability of the new forest concession system, (Barany et al. 2003) and since this is most desirable if there will continue to be adequate supply of wood then the future is bright for the LKS.
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background
4,673
This is achieved by initializing the preference vector with the expression levels of the genes in the bicluster at each particular time point and diffuse them using a random walk based on the heat kernel rank, recently shown to perform better in comparison to PageRank [32].
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method
4,674
This result differs from the findings of a study of great tits where birds with highest H/L ratios at capture (indicating higher stress level, Davis et al. 2008) inflicted the maximum extent of tail damage during the week spent in captivity (Krams et al. 2013).
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result
4,675
EP was usually used as traditional food and medicine, and previous studies suggested that biochar made from EP had good adsorption properties for dyes and zinc (Li et al., 2010, 2011).
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method
4,676
One of the key concerns by induction of reprogramming towards pluripotency in vivo may be the spontaneous occurrence of teratomas within the tissues where reprogrammed cells are generated [12,19].
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background
4,677
One can attempt to relate the jet energy to the jet scale via the Rhines relation, calculated as in Smith et al. (2002) as the integral of the putative 5 spectrum (see, e.g., Chekhlov et al. 1996; Smith et al. 2002) 1 2 U jet 2 a 2kjet 4, 3.8 where a 0.1.
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method
4,678
This finding is not consistent with an actionbased explanation of IOR and, although not precluding the idea that inhibitory processes are working at another level of the responding system (Welsh and Elliott 2004b), suggests that target localization and movement preparation are not the same process.
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result
4,679
Many recent articles have discussed the findings that support or undermine the autoimmunity hypothesis (Kierszenbaum 1986, 1999, 2003, 2005; Eisen and Kahn 1991; Avila 1992; Fernandez et al. 1992; Kalil and CunhaNeto 1996; Brener and Gazzinelli 1997; Andrade 1999; Soares et al. 2001; Leon and Engman 2001, 2002; Gironés and Fresno 2003; Gironés et al. 2005).
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4,680
The dynamometer and the experimental set-up have been described in detail elsewhere (Seger et al. 1988; Seger and Thorstensson 1994).
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method
4,681
still competent for initiating a biological response at concentrations of GM-CSF that are in the range of the Kd as shown previously (3, 7).
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method
4,682
2003) and has been described previously (Anderson et al. 2007; Perry et al. 2011; Smith et al. 2011).
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method
4,683
For instance, in a genetically derived all-cone retina mouse model lacking cone Pde6c (Nrl / ;cpfl1), it was demonstrated that the cones instead expressed the rod Pde6 catalytic subunits conferring phototransduction capability to the cones.(32) Similarly, in the rd10 mouse (which lacks the rod Pde6b gene), the cone Pde6a0 subunit was transgenically expressed in the mutant rd10 rods and this rescued the response to light, demonstrating that cone Pde6a0 can functionally substitute for Pde6ab.
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background
4,684
Uncontrolled infection, nonunion, and fixation failure are the main causes of failure of TC and TTC arthrodesis (5,6).
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background
4,685
As members of the PRR family, CLRs play a crucial role in the recognition of pathogens [45].
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background
4,686
Thus, the rest were homology modeled using the I-TASSER suite (Roy et al., 2010) with the template macrocypin 1a and were submitted to the Protein Model Database (PMDB) server which can be accessed through http://mi.caspur.it/PMDB/.
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method
4,687
Several researchers claimed a relationship to gnathiferan taxa (Winnepenninckx et al., 1998; Giribet et al., 2000; Peterson and Eernisse, 2001; Zrzavý et al., 2001; Zrzavý 2002; Giribet et al., 2004), whereas others relatedCycliophora to Entoprocta (Zrzavý et al., 1998; Sørensen et al., 2000;…
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background
4,688
TLR4 has a crucial function thatmediates signal pathway, produces inflammatory cytokines and promotes neutrophil chemotaxis in the process of corneal immune to fungal infection [13–16].
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background
4,689
Single biopsy conventional TESE was used in the study of Amer et al. (2000) and Colpi et al. (2009) where in the other study protocols multiple biopsies were taken.
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method
4,690
This perhaps suggests that the inclusion of additional punisher ratios in the present study would have yielded similar results to Lie and Alsop (2009).
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4,691
The toolchain generates the program’s CFG with estimated execution times of basic blocks by statically analyzing the program’s source code with clang and llvm [18].
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method
4,692
We suggest that this approach using DE-Seq2 or similar software, paired with phylogenetic studies of regulatory divergence (e.g., Coolon et al 2014) will continue the progress toward a broad, comparative understanding of regulatory evolution.
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4,693
(2004) and Baker et al. (2004) except that acidic deconjugation was used in the present analysis.
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4,694
This process is initiated by a double-stranded breakpoint within one arm of the Y chromosome, followed by homologous repair using the opposing arm as a template [13].
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4,695
One nodal family member Xnr3 lacks mesodermal-inducing activity via activating Smad2/3, but promotes neural induction by antagonizing BMP4 (Hansen et al., 1997; Haramoto et al., 2004).
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4,696
Similarly, in a study on 60 subjects, blinks were measured at the beginning and end of a working day (Caffier et al., 2003). Although no significant difference between alert and drowsy phases was found, a slightly decreased blink rate during drowsy phase was reported. However, these results contradict the findings of Morris and Miller (1996) about the efficiency of F in a moving base-flight simulator with 10 sleep-deprived pilots.
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4,697
We have already provided evidence of reliability and sensitivity of this technique [17, 18], which we have employed in clinical trials [19].
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method
4,698
The computational camera with the coded apertures is able to estimate the depth of the scene in a single image [3].
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4,699
Indeed, sex-specific molecular genetic markers have been developed in various organisms with heterogametic sex determination systems (e.g. Carmichael et al. 2013; Devlin et al. 2001; Felip et al. 2005; Fowler and Buonaccorsi 2016; Gamble et al. 2015; Gamble and Zarkower 2014; Griffiths and Orr 1999; Griffiths and Tiwari 1993; Griffiths et al. 1992; Kafkas et al. 2015).
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