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4,500
However, our finding partly contradicts the results of previous clinical studies, which did not detect significant elevations in SRSF5, SRSF6, and SRSF7 transcriptional levels in acute leukemia or renal cell carcinoma [14,15].
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result
4,501
Almost all of the commonly used neural simulation packages now have a Python interface (Eppler et al., 2008; Goodman and Brette, 2009; Hines et al., 2009; Cornelis et al., 2012).
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method
4,502
The selected journals were based on those used in the earlier studies by Kohl and Davis (1985) and by Nisonger and Davis (2005), additional ones suggested by participants in the latter study, and the 20 journals with the highest JIF in the Information Science and Library Science category of the…
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method
4,503
wind sector: CD 1⁄4 0:130 and CDa 1⁄4 0:132) and they are very close to the values found in literature (e.g. Amiro 1990; Kerzenmacher and Gardiner 1998; Pinard and Wilson 2001).
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background
4,504
To test this hypothesis, we first asked whether removing the KIND domain from Spire1C blocks the increase in mitochondrial division associated with overexpressing a constitutively active INF2 mutant, INF2 A149 (Korobova et al., 2013, 2014).
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background
4,505
Residues that have been shown to be phosphorylated in a study of the S. acidocaldarius phosphoproteome (Reimann et al., 2013) are indicated in blue, cysteines in red.
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background
4,506
A number of key characteristics that have previously been studied in relation to supporting alcohol tax increases (Latimer et al., 2001) were then examined through multivariate logistic regression analysis, with two separate models run to identify predictors of supporting price increases on beer and on spirits.
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method
4,507
NVsim is also used to obtain the access latencies for a given size of SRAM memory.
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method
4,508
bioreactors belong to the genus Pseudomonas, either because of their natural growth or as a result of initial inoculation (Ergas et al. 1994, 1995; Mirpuri et al. 1997; Pedersen et al. 1997; Veir et al. 1996).
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background
4,509
Both promotion (Lee et al., 2007; Sasaki-Imamura et al., 2010) and inhibition (Lee et Fig.
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background
4,510
We use successive over relaxation (SOR) algorithm [35-36] for solving all QPPs and utilize 5-fold cross-validation method in all experiments.
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method
4,511
Although a score of 9/10 has been recommended as an appropriate cut-off for screening PPD,([19]) based on current evidence for the German-speaking version a cut-off of 10/11 is used to maximize sensitivity and specificity.
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background
4,512
In fact, a previous study in the current sample demonstrated that a brief intervention was effective in reducing child behavior problems via improvements in parental positive behavior support (i.e., proactiveness, structuring, and clear communication; Dishion et al. 2008), which included aspects of warmth.
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background
4,513
Propionylations were found at 129 sites on the mid-stationary phase proteins in this study, in comparison to the 121 and 323 sites identified on midexponential and late stationary phase proteins, respectively, in our previous study (Okanishi et al. 2014).
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result
4,514
Equol is similar in structure to estradiol (See Figure 6) and is a more potent estrogen mimic than daidzein (Setchell et al. 1984).
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background
4,515
Figure 1 (top) shows the data from McCarthy and Davison (1984), which arranged four stimulus discriminability levels, and for each level, arranged three different reinforcer frequency ratios (4:1, 1:1, and 1:4).
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4,516
We assume that the liquid’s surface is undisturbed at time t = 0 and use the Harris corner detector [28] to detect corners at sub-pixel resolution.
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method
4,517
Additionally, we compare our results with the Mixed-Integer Evolution Strategy (MIES) (Li et al., 2013).
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result
4,518
The results of this study are in line with revegetation results of iron ore mines in Minas Gerais state, Brazil, where both native and introduced species performed well (Griffith and Toy, 2001).
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4,519
Similar data scatters can be seen in previous work (Fuchs et al., 1988; Van Gisbergen and Van Opstal, 1989; Broussard et al., 1995; Dean, 1996).
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result
4,520
Indeed, no CYCD6-like plant protein identified so far has the LxCxE motif, indicating that sequence divergence within this motif is a specific and group-identifying feature of D-type cyclins (Menges et al. 2007).
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4,521
These results are in accordance with the findings of Kambylafkas et al. (2006), who concluded that the use of the panoramic radiograph for evaluation of total ramal height is reliable and an asymmetry of more than 6 per cent is an indication of a true asymmetry.
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result
4,522
In order to maintain rapid proliferation, NAD+ dependence of tumor cells is higher than that of normal cells [30].
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4,523
A large body of evidence indicates that cholinergic and glutamatergic functions regulate cortical development and may contribute to postnatal critical periods (Bear and Singer, 1986; Hohmann et al., 1991; Robertson et al., 1998; for review, see Hohmann and Berger-Sweeney, 1998; Fox et al., 1999; Yuste and Sur, 1999).
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4,524
Cognitive function was measured using a computerized task battery that measures multiple modalities of cognitive performance (Green et al, 1995b).
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method
4,525
Additionally, cvp2 single mutants contained a point mutation in the cvp2 gene that results in expression of a nonfunctional protein (Carland and Nelson, 2004), and cvl1-1cvp2 double mutants with the above mutations were obtained.
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background
4,526
The Movement Disorders Society-Unified Parkinson’s Disease Rating Scale (MDS-UPDRS) rating scale [21] was used to assess the severity of the motor symptoms at the time of the experiment by an experienced neurologist (AA).
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method
4,527
With respect to acquired risk factors for VTE, immobilization, surgery, and trauma account for 40% to 80% of VTE cases in Caucasians [38-41].
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4,528
Furthermore, in Section 9.8, we compare the IMT algorithm with state-of-the-art trackers including the MIL [2], TLD [18], VTD [20], VTS [21], Struck [13], ASLA [16], SCM [37], CXT [8], LSK [23], CSK [14], and KCF [15] methods.
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method
4,529
[21] formulated ISI problem under the name of k-effector and introduced the minimization of the symmetric difference between the observed infection and the resulting cascade if starting from a candidate source set.
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4,530
Inverted formin 2 (INF2) is a formin family protein that promotes actin filament polymerization in a regulated fashion (Korobova et al., 2013, 2014).
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background
4,531
Diabetes Complication Rates To estimate the health benefits of screening, we used a mathematical model, the United Kingdom Prospective Diabetes Study (UKPDS) Outcomes Model 2, which includes South Asian– specific disease progression parameters that have been validated among South Asians in both the UK and India [33,34].
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method
4,532
5x10 for patients aged 16-40 years and 8x10 for patients older than 41 (Andersson et al., 1994).
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background
4,533
Following (Campbell et al. 2001) we decompose the return of a typical stock into three components: the market-wide return, an industry-specific return, and a firmspecific return.
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method
4,534
…five experimental groups were selected to compare the metabolite profiles associated with different manifestations of IVA, as follows: (1) The first group consisted of children with the homozygous mutation of the IVD gene (homozygotes), but showing clinical variability (Dercksen et al. 2012).
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method
4,535
The intensity of choice β is sometimes denoted λ and has also been referred to as response sensitivity [12, 13, 18] or learning sensitivity [19].
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4,536
…is planned for patients with locally advanced carcinomas or with tumors primarily not suitable for breast-conserving surgery, thus the first aim of this therapeutic option is to downsize the disease burden and possibly to achieve pathologic complete response (pCR) (Marchio and Sapino, 2011).
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4,537
This conclusion is consistent with previous results (7, 21, 22) that suggest that the increase in ALC produced by the b-adrenergic agonists isoproterenol and terbutaline is characterized by an increase in the proportion of the total sodium transport that is amiloride-sensitive.
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result
4,538
3, 4, this study), have been linked repeatedly to observed UV-B-induced reductions in herbivory, larval development and larval survivorship (McCloud and Berenbaum 1994; Ballaré et al. 1996; Grant Petersson and Renwick 1996; Lindroth et al. 2000; Rousseaux et al. 2004).
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4,539
The exercise of self-control was manipulated by assigning participants at random to one of two viewing conditions (similar to Muraven et al., 1998; Vohs & Heatherton, 2000; Vohs & Schmeichel, 2003).
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method
4,540
Macrobenthic organisms were classified into five different feeding groups: detritivores (surface-deposit feeders, SDF; suspension feeders, SF; subsurfacedeposit feeders, SSDF), herbivores (He) and predators (PR), according to Bianchi & Morri (1985), Gambi & Giangrande (1985), Scipione (1989), Russo (1989), Russo et al.
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background
4,541
been shown that chronic intoxication with MCs promotes liver tumor formation [27,28], induces kidney injury [29,30] and causes atrophy and fibrosis of the heart muscle [31,32].
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background
4,542
To avoid the issues encountered in the gradient-based approaches, many population-based computational techniques such as genetic algorithm [2] and swarm intelligence algorithms [3] have been proposed for solving optimization problems.
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method
4,543
To make our study comparable with previous studies [6,7,24], we restrict our analysis to 51 species (Table S1) which have more than 70 individuals with Diameter at Breast Height (DBH) greater than 10 cm.
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method
4,544
Static complexes modified by 82Q in the presence of NusA but not in its absence resist both an oligonucleotide-mediated release reaction that models the intrinsic terminator (126, 156) and the activity of Rho (126); the latter suggests either that Rho has an obligatory target site in the region where RNA emerges, or that the Q-modified complex is strengthened enough to resist the force of the Rho translocase.
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4,545
We compare the spike reconstruction efficiency of our method to two different types of established spike reconstruction methods: 1) template matching [85], and 2) a deconvolution-based method [71].
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method
4,546
In hepatocytes, membrane potential and pH changes are detected, which suppress and activate many enzymes that optimally operate at a neutral pH, and lead to edema and necrosis [21, 23, 33, 64, 100, 101, 107–115].
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4,547
However, several preclinical and clinical studies showed both compounds are ineffective in melanoma, due to the major RAS mutations occur in melanoma are NRAS mutation, rather than HRAS and KRAS [1].
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4,548
Pricing via a coherent risk measure was first introduced by Artzner et al. (1999) and it reduces to a search for the infimum of all risk measures over an acceptance set. Carr et al. (2001) refine the idea and introduce a generalized version of the coherent risk measure.
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4,549
In previous experiments, intravenous lipid emulsions have been shown to ameliorate the toxicity of a number of lipid soluble agents [5–10].
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background
4,550
To detect interest points in a video, we use the sparse Harris3D corner detector [16].
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method
4,551
1) [24,46], and hair bundle displacement leading to an adapting MET current (IT from Eq.
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background
4,552
In the chicken and owl, Tanaka and Smith (1978) and Smith et al. (1985) describe a special type of ‘short’ hair cell, the ‘lenticular’ hair cell.
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4,553
The KOOS score has been used in numerous clinical studies on knee injuries,(9,19,52,55,57) and the literature supports both acceptable test-retest reliability and validity.(9,19,56,57) The KOOS consists of 5 subscales: (1) pain, (2) other symptoms, (3) function in activities of daily living (ADLs), (4) function in sports and recreation (sports), and (5) knee-related quality of life (QOL).
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method
4,554
Among the most successful are Spectral Sequencing [62], Optimally Oriented Decomposition Tree [6], Multilevel based [68], Simulated Annealing [79, 78], Genetic Hillclimbing [81] and some of their combinations.
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background
4,555
Receptors containing the subunits 4 in the dentate gyrus, 5 in CA1 pyramidal cells, and 6 in the cerebellum are prominent examples of tonically activated GABAARs (Caraiscos et al., 2004; Farrant and Nusser, 2005).
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4,556
So far, various investigations on the chemistry and microbiology related to the axillary odor have been performed, most of them on Caucasians (Russell, 1976; Doty et al., 1978; Leyden et al., 1981; Rennie et al., 1991; Zeng et al., 1991, 1992, 1996a).
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4,557
This strong secretion and accumulation in the extracellular matrix of all cell types under low water availability denotes that these PRPs may be involved in the maintenance of cellular integrity (Millar et al. 1992; García-Gómez et al. 2000; Murphy et al. 2002).
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4,558
13 indicates the comparison of the results of the mesh simplification method [2] after applying different mesh enhancement techniques.
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method
4,559
05mg ZOL.(42) Additionally, there are investigations demonstrating an enhanced local bone formation resulting from direct elution of ZOL from porous implants, persisting for 1 year after surgery.
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4,560
The finding in men was consistent with the finding from the Multi-Ethnic Study of Atherosclerosis study, in which sedentary behavior was associated with CAC among participants free of diagnosed cardiovascular diseases [17].
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4,561
In another report, the authors found that a reduction in DV risk was associated with secondary education for the woman and her partner; there was less consistent evidence of a protective effect of primary education.22 Women who reported DV were likely to report that their spouses had completed at least primary or secondary education (p<0.0001); however, we did not find a significant association between spousal income and DV. Previous analyses of community samples have shown that that low socioeconomic status24 25 26 and low educational status were significant predictors of DV.4 24 26 27 In addition, other studies have found that indicators of household economic prosperity and education of the male partner were inversely associated with the risk of DV.28 29 Findings from a community and clinical study indicated that among the demographic factors that were determinants of DV, the more children a woman had, the less likely was she to be beaten by her partner.28 30 On the contrary, our analyses showed that abused women were more likely to have more children than their non-abused peers.
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method
4,562
2009–2012) is similar to the incidence rate variation observed in multiple cohorts, in both high-income and low-income settings [3,6,15,39], and in our setting it might be a result of overall antiretroviral therapy expansion.
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4,563
This element was shown to be typical for European cattle and was absent from the Bos indicus GHR gene (Hale et al., 2000).
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4,564
In this study, the users’ perception of quality shows a much stronger impact on intention than previous studies on IT use have indicated (Beyah et al., 2003; Cheong and Park, 2005; Shin, 2008).
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4,565
In mice transgenic for mutant human APP, the increase in amyloid-b peptides reduced cerebral blood flow through enhanced vasoconstriction, and impaired both functional hyperaemia and cerebral autoregulation (Niwa et al., 2001, 2002a, b).
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4,566
A moderate level of CB1-immunoreactivity was found in the lateral and basomedial nucleus, which is coherent with previous results (McDonald and Mascagni, 2001; Katona et al, 2001).
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4,567
Two similar systematic reviews/meta-analyses have been published comparing ACDF with ACCF.(13,14) However,
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4,568
Based on the definitions of the OISR tuple elements, we introduce an evaluation framework, which is a specialisation of the BWW evaluation framework [15,16] that is aimed at assessing the expressive power of modelling methods to be applied for OISR representation.
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method
4,569
In order to keep our analysis specific to independent primary research from surgical STMMs we used the following inclusion and exclusion criteria that left us with a total of 35 independent primary research articles focused on surgical STMMs [18-52].
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method
4,570
In addition, the rows in the stoichiometric matrix M corresponding to the mass balances of the dependent enzyme states can be eliminated so that a new, reduced, stoichiometric matrix MR is formed (Heinrich and Schuster, 1996; Reder, 1988).
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4,571
Marginal structural modeling was used to address potential confounding between time-dependent variables in the Cox proportional hazard regression models [17].
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4,572
When the IF cells are mixed with paramecia, the bacteria are soon engulfed in the host digestive vacuoles, from which they escape to the host cytoplasm and penetrate the macronuclear envelope with the invasion tip (Fujishima & Fujita, 1985; Görtz & Wiemann, 1989; Iwatani et al., 2005).
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4,573
The power of the meta-analysis was assessed according to the literature (Chinn, 2000; Hedges and Pigott, 2001; Muncer et al., 2002), at an a = 0.
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method
4,574
The results of the 2-year illicit drug use outcomes from the full Preventure Trial (Waves 1 and 2 combined) were then reported by Conrod et al. (2010), showing that the intervention was associated with a greater likelihood of surviving 2 years without taking up drug use.
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background
4,575
We use kernel matching8 with replacement, which has a major advantage of lower variance given that the common support condition is fully satisfied (Caliendo & Kopeinig, 2008) as it is for all estimates reported below.
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method
4,576
Data were collected in a cross-sectional survey for the Primary Health Care Project on HIV and Depression (Mao et al. 2008, 2009a, 2009b).
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4,577
Our results are in accordance with a recent Japanese study by Hidaka et al (11), who reported excellent maternal outcome and favorable fetal outcome.
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result
4,578
Phosphorylation of S339CXCR4 correlates with CXCR4 internalization and signaling.(18,40,41) Interestingly, ligation of TCR significantly increased phosphorylation of S339-CXCR4 (Figure 2L-M).
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4,579
Using this strategy, we inductively derived ideas and categories from the data and then deductively compared and adapted them through ongoing sampling and data collection (Beck, 2004; Wuest, 2007).
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method
4,580
This constitutes an improvement over previous synoptic giant panda habitat evaluations in which the presence of understory bamboo was ignored (Liu et al., 2001; Loucks et al., 2003; Viña et al., 2007) due to the difficulty in isolating its signal from that of overstory canopy (Linderman et al.
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4,581
Participants Participants were mothers and children recruited as part of the large, ongoing Early StepsMultisite trial of the Family CheckUp parenting intervention (Dishion et al. 2008).
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background
4,582
…more accurate depiction of epidemiological findings supporting the core group hypothesis (Rothenberg 1983; Potterat et al. 1985; Zenilman et al. 1999; Bernstein et al. 2004), and resolves some of the prior ambiguity about what constitutes the core group for STI transmission (Thomas & Tucker 1996).
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background
4,583
other fern gametophytes and sporophytes, we conducted a preliminary analysis with all Glomus sequences from Botrychium (Ophioglossaceae; Kovács et al. 2007; Winther and Friedman 2007), Lycopodiaceae (Winther and Friedman 2008) and Psilotum nudum (Psilotaceae; Winther and Friedman 2009) reported in GenBank.
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4,584
This result is in accordance with the phylogenetic tree analysis of two other pufferfish genes identified recently, IFN and ISG15 (Altmann et al., 2003; Liu et al., 2002).
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result
4,585
The most popular ESIPT probes are 3-hydroxychromones, which are largely used to investigate lipid membrane properties [14], as well as protein-membrane [15] and protein-nucleic acid [16, 17] interactions.
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4,586
2%) but is similar to previous reports of a 2% to 6% incidence after the minimally invasive and conventional technique [11, 18, 19, 21, 22].
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method
4,587
In particular, the delivery of AONs allowed the skipping of one or multiple exons of the DMD gene to reframe the mutated transcript and create a partially functional dystrophin protein [11, 12].
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4,588
Matching Method: Various approximate nearest neighbors alternatives have been proposed in the literature [6, 11, 4] in order to accelerate the matching process between feature descriptors.
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method
4,589
Together with M2R, M3R are the most represented in human airways; they are predominantly expressed in SM cells and mediate SM ACh-induced contraction [16, 20].
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background
4,590
In terms of the chemical compounds observed following laser irradiation in vacuum, there were no detectable differences between excimer laser-irradiated areas and those seen in non-irradiated titanium surfaces [15].
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4,591
…SNX3 is enriched at early endosomes, retromer tubules formed by the Vps5 and Vps17 homologues SNX1/2 and SNX5/6, respectively (Wassmer et al., 2009), are most abundant on endosomes undergoing the early-to-late transition (Rojas et al., 2008; Cullen and Korswagen, 2012; van Weering et al., 2012).
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4,592
This result supports an earlier study on the negative interrelationship between initial density and decomposition rate (Harmon et al. 1995).
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result
4,593
When rad53Δ, mrc1Δ or ctf18Δ cells are treated with hydroxyurea, we found previously that Mec1-signalling at defective replication forks is increased, as reflected by increased Mec1-dependent phosphorylation of the Psf1 subunit of the Cdc45-MCM-GINS (CMG) DNA helicase (42).
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4,594
Some previous studies reported temporal and spatial variations of gaseous and particulate matter pollutants in China (Chai et al., 2014; Chen and Xie, 2014; Han et al., 2009; Johansson et al., 2007; Karar et al., 2006; Lewne et al., 2004; Li et al., 2014; Martini et al., 2015; Meng et al., 2009; Sun et al., 2013; Wang et al., 2008, 2014d; Zhang et al., 2014; Zheng et al., 2013), but detailedly observational data were scarce.
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4,595
Pre-intervention survey data (n=65) was collected during the first week of class and postintervention survey data (n=65) the last week of class using the Mediterranean Diet Quality Index (KIDMED) developed and validated by SerraMajem et al.(10) The nutrition intervention was based on the MD as a weight management guideline and incorporated assigned readings, article reviews, recipe analysis, weekly discussion forums, asynchronous presentations, writing assignments, and exams.
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method
4,596
Prior CLHNS studies noted that CRP levels were substantially lower in the Philippines than in the USA [9, 10].
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4,597
Identity begins to take shape during adolescence, but, with the incorporation of new life experiences, is continually modified throughout adulthood (McLean, 2008).
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4,598
Training: We built separate directed word alignments for English→Arabic and for Arabic→English using IBM model 4 [19], and symmetrized them using grow-diag-final-and heuristic [20].
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method
4,599
Sorption effects of CNT to different pollutants present in the environment has been studied by several authors [33-38,53,65-72].
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