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A patient with disseminated herpes zoster developed a syndrome of inappropriate antidiuretic hormone and profound hyponatremia secondary to the administration of adenine arabinoside. | [
{
"ade": "hyponatremia",
"drug": "adenine arabinoside"
},
{
"ade": "syndrome of inappropriate antidiuretic hormone",
"drug": "adenine arabinoside"
}
]
|
We conjectured that the side effects of insulin, such as anti-natriuresis and increased vascular permeability, might be pronounced in the presence of the hepatic dysfunction that accompanies insulin insensitivity, hyperinsulinaemia and hypoalbuminaemia. | [
{
"ade": "hypoalbuminaemia",
"drug": "insulin"
},
{
"ade": "hyperinsulinaemia",
"drug": "insulin"
},
{
"ade": "anti-natriuresis",
"drug": "insulin"
},
{
"ade": "increased vascular permeability",
"drug": "insulin"
},
{
"ade": "insulin insensitivity",
"drug": "insulin"
}
]
|
Methysergide-induced retroperitoneal fibrosis: successful outcome and two new laboratory features. | [
{
"ade": "retroperitoneal fibrosis",
"drug": "Methysergide"
}
]
|
Pulmonary toxicity associated with erlotinib. | [
{
"ade": "Pulmonary toxicity",
"drug": "erlotinib"
}
]
|
Our literature review revealed an additional six cases of onset of inflammatory arthritis in MS patients receiving IFN-beta. | [
{
"ade": "inflammatory arthritis",
"drug": "IFN-beta"
}
]
|
Thus, an immunological mechanism might be involved in the mechanism of pirmenol-induced QT prolongation and T wave inversion on the electrocardiogram. | [
{
"ade": "T wave inversion",
"drug": "pirmenol"
},
{
"ade": "QT prolongation",
"drug": "pirmenol"
}
]
|
Two patients with ovarian cancer who had received multiple courses of cisplatin without complications experienced hypersensitivity reactions to cisplatin: one, involving intrahepatic artery infusion, manifested general erythema, dyspnea, and hypotension; the other, involving intravenous infusion, manifested abdominal pain, general erythema, and fever. | [
{
"ade": "general erythema",
"drug": "cisplatin"
},
{
"ade": "abdominal pain",
"drug": "cisplatin"
},
{
"ade": "dyspnea",
"drug": "cisplatin"
},
{
"ade": "fever",
"drug": "cisplatin"
},
{
"ade": "hypotension",
"drug": "cisplatin"
},
{
"ade": "hypersensitivity reactions",
"drug": "cisplatin"
}
]
|
OBJECTIVE: To evaluate the efficacy of the administration of insulin by a jet-injector device in stopping and reversing severe human insulin-induced lipoatrophy. | [
{
"ade": "lipoatrophy",
"drug": "human insulin"
}
]
|
Clinicians should be aware of the possibility that vinorelbine may cause SIADH and possibly hypokalemia. | [
{
"ade": "hypokalemia",
"drug": "vinorelbine"
},
{
"ade": "SIADH",
"drug": "vinorelbine"
}
]
|
From 1996 to 2002 several medications were changed due to their adverse effects: indinavir (renal colic and fever), nelfinavir (cutaneous rash), and efavirenz (nausea and temporary memory loss). | [
{
"ade": "renal colic",
"drug": "indinavir"
},
{
"ade": "fever",
"drug": "indinavir"
},
{
"ade": "cutaneous rash",
"drug": "nelfinavir"
},
{
"ade": "nausea",
"drug": "efavirenz"
},
{
"ade": "temporary memory loss",
"drug": "efavirenz"
}
]
|
The purpose of this review is to increase awareness among physicians and other health care professionals that DIC may be a rare but potentially severe complication of anti-D IGIV treatment. | [
{
"ade": "DIC",
"drug": "anti-D IGIV"
}
]
|
Tamoxifen is suggested to be carcinogenic both through direct genotoxic and epigenetic mechanisms. | [
{
"ade": "carcinogenic",
"drug": "Tamoxifen"
}
]
|
To our knowledge, these cases are the first published reports of lovastatin-induced rhabdomyolysis associated with azithromycin and clarithromycin. | [
{
"ade": "rhabdomyolysis",
"drug": "lovastatin"
},
{
"ade": "rhabdomyolysis",
"drug": "clarithromycin"
},
{
"ade": "rhabdomyolysis",
"drug": "azithromycin"
}
]
|
A diagnosis of trastuzumab-induced pneumonitis was made. | [
{
"ade": "pneumonitis",
"drug": "trastuzumab"
}
]
|
Marked elevation of serum creatine kinase associated with olanzapine therapy. | [
{
"ade": "elevation of serum creatine kinase",
"drug": "olanzapine"
}
]
|
Quetiapine-induced myoclonus. | [
{
"ade": "myoclonus",
"drug": "Quetiapine"
}
]
|
Although the data indicate an immune-complex cause for gold-salt nephropathy, the incident antigen (or antigens) and mechanism of action remain unidentified. | [
{
"ade": "nephropathy",
"drug": "gold-salt"
}
]
|
OBJECTIVE: To describe a case of severe skin necrosis resulting from peripheral intravenous administration of low-dose vasopressin in a patient with catecholamine-resistant septic shock. | [
{
"ade": "skin necrosis",
"drug": "vasopressin"
}
]
|
This entity is probably related to a combination of high doses of corticosteroids, vecuronium administration and metabolic abnormalities associated with respiratory failure. | [
{
"ade": "respiratory failure",
"drug": "vecuronium"
}
]
|
CONCLUSIONS: Hypersensitivity reactions to cyclosporine are due to Cremophor EL. | [
{
"ade": "Hypersensitivity reactions",
"drug": "cyclosporine"
},
{
"ade": "Hypersensitivity reactions",
"drug": "Cremophor EL"
}
]
|
Acute myeloid leukemia evolving from essential thrombocythemia in two patients treated with hydroxyurea. | [
{
"ade": "Acute myeloid leukemia",
"drug": "hydroxyurea"
}
]
|
Ritonavir should be added to the list of drugs that can induce adverse cutaneous reactions in HIV patients. | [
{
"ade": "adverse cutaneous reactions",
"drug": "Ritonavir"
}
]
|
Mannitol-induced ARF responds promptly to hemodialysis with rapid resolution of anuria and recovery of renal failure. | [
{
"ade": "ARF",
"drug": "Mannitol"
}
]
|
While the mechanism of dextran-associated renal failure remains unsolved, plasma exchange seems to be effective therapy. | [
{
"ade": "renal failure",
"drug": "dextran"
}
]
|
The case is presented of a 72-year-old man with hormone-refractory prostate cancer and weekly administration of 30 mg/m2 docetaxel who developed subacute interstitial pneumonitis-related pulmonary fibrosis after seven doses and died despite mechanical ventilation and high-dose corticosteroid treatment. | [
{
"ade": "subacute interstitial pneumonitis-related pulmonary fibrosis",
"drug": "docetaxel"
}
]
|
A 45-year-old woman with thyrotoxicosis developed agranulocytosis after treatment with propylthiouracil. | [
{
"ade": "agranulocytosis",
"drug": "propylthiouracil"
}
]
|
BACKGROUND: Colchicine has a known adverse effect on wound healing through its inhibitory effect on tubulin-dependent cell functions and through collagenase activation. | [
{
"ade": "collagenase activation",
"drug": "Colchicine"
},
{
"ade": "adverse effect on wound healing",
"drug": "Colchicine"
}
]
|
DISCUSSION: This case shows that switching to zidovudine potentially can lead to a hyperlactatemia relapse. | [
{
"ade": "hyperlactatemia relapse",
"drug": "zidovudine"
}
]
|
In one child, a second course of carbamazepine resulted in a return of the dystonia. | [
{
"ade": "dystonia",
"drug": "carbamazepine"
}
]
|
PURPOSE: To report two cases in which topical brimonidine resulted in apparent central nervous system depression and unresponsiveness in an infant. | [
{
"ade": "central nervous system depression",
"drug": "brimonidine"
}
]
|
Increased libido in a woman treated with fluvoxamine: a case report. | [
{
"ade": "Increased libido",
"drug": "fluvoxamine"
}
]
|
Enalaprilat induced acute parotitis. | [
{
"ade": "acute parotitis",
"drug": "Enalaprilat"
}
]
|
It should be emphasized that the recurrence of nephrotic syndrome was observed after the following chemotherapy, including M-CSF, whereas the bone marrow still remained completely remitted. | [
{
"ade": "nephrotic syndrome",
"drug": "M-CSF"
}
]
|
Pellagra encephalopathy among tuberculous patients: its relation to isoniazid therapy. | [
{
"ade": "Pellagra encephalopathy",
"drug": "isoniazid"
}
]
|
We report two young patients with cystic fibrosis who presented with acute renal insufficiency after 2-3 weeks of oral ciprofloxacin therapy. | [
{
"ade": "acute renal insufficiency",
"drug": "ciprofloxacin"
}
]
|
We report a case of generalized cutaneous sclerosis associated with muscle and oesophageal involvement in a patient exposed to herbicides containing bromocil, diuron and aminotriazole. | [
{
"ade": "generalized cutaneous sclerosis",
"drug": "diuron"
},
{
"ade": "generalized cutaneous sclerosis",
"drug": "bromocil"
},
{
"ade": "generalized cutaneous sclerosis",
"drug": "aminotriazole"
}
]
|
Rituximab-based therapy for gemcitabine-induced hemolytic uremic syndrome in a patient with metastatic pancreatic adenocarcinoma: a case report. | [
{
"ade": "hemolytic uremic syndrome",
"drug": "gemcitabine"
}
]
|
Acute eosinophilic pneumonia caused by calcium stearate, an additive agent for an oral antihistaminic medication. | [
{
"ade": "Acute eosinophilic pneumonia",
"drug": "calcium stearate"
}
]
|
Neutropenia is an infrequent complication following administration of the angiotensin-converting enzyme (ACE) inhibitor, captopril. | [
{
"ade": "Neutropenia",
"drug": "captopril"
}
]
|
PURPOSE: To report a case of nodular scleritis following alendronate sodium. | [
{
"ade": "nodular scleritis",
"drug": "alendronate sodium"
}
]
|
We report here a 26-year-old female with diffuse large B-cell lymphoma who died of severe pulmonary fibrosis 81 days after the administration of high-dose BCNU (600 mg/m2). | [
{
"ade": "severe pulmonary fibrosis",
"drug": "BCNU"
}
]
|
Trimethoprim-sulfamethoxazole-induced hepatotoxicity in a pediatric patient. | [
{
"ade": "hepatotoxicity",
"drug": "Trimethoprim-sulfamethoxazole"
}
]
|
Drug-induced mammary hyperplasias have been reported as rare complications of D-penicillamine and Neothetazone. | [
{
"ade": "mammary hyperplasias",
"drug": "D-penicillamine"
},
{
"ade": "mammary hyperplasias",
"drug": "Neothetazone"
}
]
|
Spontaneous hemothorax following anticoagulation with low-molecular-weight heparin. | [
{
"ade": "Spontaneous hemothorax",
"drug": "heparin"
}
]
|
Ketanserin in the treatment of protamine-induced pulmonary hypertension. | [
{
"ade": "pulmonary hypertension",
"drug": "protamine"
}
]
|
Mental nerve neuropathy as a result of hepatitis B vaccination. | [
{
"ade": "Mental nerve neuropathy",
"drug": "hepatitis B vaccination"
}
]
|
Pulmonary fibrosis associated with nabumetone. | [
{
"ade": "Pulmonary fibrosis",
"drug": "nabumetone"
}
]
|
Increasing the olanzapine dosage severely aggravated the symptoms of RLS. | [
{
"ade": "RLS",
"drug": "olanzapine"
}
]
|
CONCLUSION: Gemcitabine-induced recall pneumonitis is a rarely reported phenomenon and should be taken into account even after extended time interval to the previous radiotherapy. | [
{
"ade": "recall pneumonitis",
"drug": "Gemcitabine"
}
]
|
We report a 59-year-old patient with chronic myeloid leukemia, who developed severe interstitial lung fibrosis after short term and sequential treatment with melphalan and busulfan. | [
{
"ade": "severe interstitial lung fibrosis",
"drug": "busulfan"
},
{
"ade": "severe interstitial lung fibrosis",
"drug": "melphalan"
}
]
|
Patients should be informed about the risk of osteonecrosis when taking dexamethasone as an antiemetic drug. | [
{
"ade": "osteonecrosis",
"drug": "dexamethasone"
}
]
|
Six patients with rheumatoid arthritis developed a syndrome resembling lupus erythematosus while being treated with penicillamine. | [
{
"ade": "lupus erythematosus",
"drug": "penicillamine"
}
]
|
Leukaemoid monocytosis in M4 AML following chemotherapy and G-CSF. | [
{
"ade": "Leukaemoid monocytosis",
"drug": "G-CSF"
}
]
|
CONCLUSIONS: Symptoms and pathologic changes of colitis are associated with exposure to rofecoxib. | [
{
"ade": "colitis",
"drug": "rofecoxib"
}
]
|
We report four cases of hemodynamically significant pericardial effusion in patients with refractory lymphoma who were receiving gemcitabine, all of whom had a history of mediastinal radiation without subcarinal blocking. | [
{
"ade": "pericardial effusion",
"drug": "gemcitabine"
}
]
|
Drug-induced agranulocytosis during treatment with infliximab in enteropathic spondyloarthropathy. | [
{
"ade": "agranulocytosis",
"drug": "infliximab"
}
]
|
A 10-year-old girl with Lennox-Gastaut syndrome who received intravenous lorazepam for atypical absence status seizures is reported. | [
{
"ade": "seizures",
"drug": "lorazepam"
}
]
|
We report a case of fatal fulminant hepatitis caused by the use of disulfiram in a man with previously normal hepatocellular function. | [
{
"ade": "fatal fulminant hepatitis",
"drug": "disulfiram"
}
]
|
The authors' results suggest that L-dopa may cause daytime somnolence in some patients with Parkinson's disease. | [
{
"ade": "daytime somnolence",
"drug": "L-dopa"
}
]
|
Currently the use of zidovudine is one of the few specific measures available, and as a potentially teratogenic and fetotoxic agent, any decision for its use requires evaluation of the potential for fetal damage. | [
{
"ade": "teratogenic",
"drug": "zidovudine"
},
{
"ade": "fetotoxic",
"drug": "zidovudine"
},
{
"ade": "fetal damage",
"drug": "zidovudine"
}
]
|
Incomplete posterior hyaloid detachment after intravitreal pegaptanib injection in diabetic macular edema. | [
{
"ade": "Incomplete posterior hyaloid detachment",
"drug": "pegaptanib"
}
]
|
Bromide intoxication secondary to pyridostigmine bromide therapy. | [
{
"ade": "Bromide intoxication",
"drug": "pyridostigmine bromide"
}
]
|
We report a patient who developed spontaneous splenic infarction after the use of sumatriptan for the treatment of migraine headache. | [
{
"ade": "spontaneous splenic infarction",
"drug": "sumatriptan"
}
]
|
The multiple comedones and ruptured epidermoid cysts are newly reported adverse effects of imiquimod therapy. | [
{
"ade": "multiple comedones",
"drug": "imiquimod"
},
{
"ade": "ruptured epidermoid cysts",
"drug": "imiquimod"
}
]
|
Serotonin syndrome caused by interaction between citalopram and fentanyl. | [
{
"ade": "Serotonin syndrome",
"drug": "citalopram"
},
{
"ade": "Serotonin syndrome",
"drug": "fentanyl"
}
]
|
Contrary to previous recommendations, our experience cautions against the further use of high-dose cytarabine in patients who develop PPE, and is a timely reminder of the potential toxicity of this agent, which is now increasingly being used as first-line treatment in the management of haematologic malignancies. | [
{
"ade": "PPE",
"drug": "cytarabine"
}
]
|
Four patients in whom pulmonary oedema developed during tocolysis with hexoprenaline are described and the aetiological factors and pathogenesis of this potentially lethal complication discussed. | [
{
"ade": "pulmonary oedema",
"drug": "hexoprenaline"
}
]
|
A patient with psoriasis is described who had an abnormal response to the glucose tolerance test without other evidence of diabetes and then developed postprandial hyperglycemia and glycosuria during a period of topical administration of a corticosteroid cream, halcinonide cream 0.1%, under occlusion. | [
{
"ade": "glycosuria",
"drug": "halcinonide"
},
{
"ade": "postprandial hyperglycemia",
"drug": "halcinonide"
}
]
|
The diagnosis was supported by the temporal course of renal deterioration during exposure to cefuroxime and improvement on its discontinuation; the pattern repeated with rechallenge. | [
{
"ade": "renal deterioration",
"drug": "cefuroxime"
}
]
|
We report on three observations of parkinsonian patients with levo-dopa-induced diphasic dyskinesias, who received subcutaneous apomorphine to reduce the duration of abnormal movements. | [
{
"ade": "diphasic dyskinesias",
"drug": "levo-dopa"
}
]
|
The time course of events suggested that amphotericin B was the cause of the seizures in this AIDS patient. | [
{
"ade": "seizures",
"drug": "amphotericin B"
}
]
|
OBJECTIVE: To describe the development of valproate-related reproductive endocrine disorders in women with epilepsy. | [
{
"ade": "reproductive endocrine disorders",
"drug": "valproate"
}
]
|
Proton MRS examination demonstrated a persistent lactate elevation during metronidazole treatment. | [
{
"ade": "lactate elevation",
"drug": "metronidazole"
}
]
|
Used injudiciously, naloxone can lead to withdrawal syndrome, return of severe pain, and other adverse effects. | [
{
"ade": "severe pain",
"drug": "naloxone"
},
{
"ade": "withdrawal syndrome",
"drug": "naloxone"
}
]
|
Immobilization, while Paget's bone disease was present, and perhaps enhanced activation of dihydrotachysterol by rifampicin, could have led to increased calcium-release into the circulation. | [
{
"ade": "increased calcium-release",
"drug": "dihydrotachysterol"
}
]
|
We report the case of a woman who developed photo-onycholysis on multiple nails after uptake of olanzapine. | [
{
"ade": "photo-onycholysis",
"drug": "olanzapine"
}
]
|
Based on the clinical status of the patient, it was suspected that several conditions contributed to the abnormal hypersensitivity to warfarin. | [
{
"ade": "abnormal hypersensitivity",
"drug": "warfarin"
}
]
|
Pulmonary leukostasis secondary to all-trans retinoic acid in the treatment of acute promyelocytic leukemia in first relapse. | [
{
"ade": "Pulmonary leukostasis",
"drug": "all-trans retinoic acid"
}
]
|
Lithium-induced Creutzfeldt-Jakob syndrome. | [
{
"ade": "Creutzfeldt-Jakob syndrome",
"drug": "Lithium"
}
]
|
A 48-year-old woman who was treated for thyrotoxicosis with methimazole developed agranulocytosis. | [
{
"ade": "agranulocytosis",
"drug": "methimazole"
}
]
|
In our patient, an objective causality scale showed that therapeutic doses of colchicine for FMF were the definite cause of myopathy, even though his renal and hepatic function were normal. | [
{
"ade": "myopathy",
"drug": "colchicine"
}
]
|
Torsade de pointes represents a potential complication of chronic amiodarone therapy. | [
{
"ade": "Torsade de pointes",
"drug": "amiodarone"
}
]
|
He had an immediate hypersensitivity reaction during the initiation of the MTX infusion with diffuse urticaria, facial swelling, cough, and chest tightness. | [
{
"ade": "hypersensitivity reaction",
"drug": "MTX"
},
{
"ade": "chest tightness",
"drug": "MTX"
},
{
"ade": "diffuse urticaria",
"drug": "MTX"
},
{
"ade": "facial swelling",
"drug": "MTX"
},
{
"ade": "cough",
"drug": "MTX"
}
]
|
The treatment for acidosis and hyperkalaemia should be started as soon as RTA is diagnosed, and the dosage of FK506 should also be reduced if possible. | [
{
"ade": "RTA",
"drug": "FK506"
}
]
|
Disulfiram-like reactions with newer cephalosporins: cefmenoxime. | [
{
"ade": "Disulfiram-like reactions",
"drug": "cefmenoxime"
}
]
|
Baclofen withdrawal: a cause of prolonged fever in the intensive care unit. | [
{
"ade": "fever",
"drug": "Baclofen"
}
]
|
Niacin causes a reversible toxic cystoid maculopathy that occurs in approximately 0.67% of patients taking high doses of the drug. | [
{
"ade": "reversible toxic cystoid maculopathy",
"drug": "Niacin"
}
]
|
Comeoscleral perforation after pterygium excision and intraoperative mitomycin C. | [
{
"ade": "Comeoscleral perforation",
"drug": "mitomycin C"
}
]
|
The principle treatment for DPD-deficient patients with severe acute 5-FU reactions is supportive care; however, the administration of thymidine potentially may reverse severe 5-FU-induced neurologic symptoms such as encephalopathy and coma. | [
{
"ade": "coma",
"drug": "5-FU"
},
{
"ade": "encephalopathy",
"drug": "5-FU"
},
{
"ade": "neurologic symptoms",
"drug": "5-FU"
},
{
"ade": "severe acute 5-FU reactions",
"drug": "5-FU"
}
]
|
We describe the exceptional development of AML and lung cancer in a patient with previously diagnosed CLL in minimal residual disease status after fludarabine treatment followed by autologous peripheral blood stem-cell transplantation. | [
{
"ade": "AML",
"drug": "fludarabine"
},
{
"ade": "lung cancer",
"drug": "fludarabine"
}
]
|
A 58-year-old man with advanced renal cell carcinoma developed grade 3 proteinuria (8.5 g/24 h) without microscopic hematuria or renal insufficiency five days after temsirolimus infusion. | [
{
"ade": "proteinuria",
"drug": "temsirolimus"
}
]
|
Oral intake and acarbose were withheld and the ileus spontaneously resolved after 2 days. | [
{
"ade": "ileus",
"drug": "acarbose"
}
]
|
In two patients with mycosis fungoides, a squamous cell carcinoma developed during therapy with psoralens plus long-wave ultraviolet radiation (PUVA). | [
{
"ade": "squamous cell carcinoma",
"drug": "psoralens"
}
]
|
CASE REPORT: We report a patient who developed a DAT-positive hemolytic episode after a red cell (RBC) transfusion was delivered during the infusion of her 17th cycle of oxaliplatin. | [
{
"ade": "DAT-positive hemolytic episode",
"drug": "oxaliplatin"
}
]
|
Epstein-Barr virus-associated lymphoproliferative disorder in a patient with rheumatoid arthritis on methotrexate and rofecoxib: idiosyncratic reaction or pharmacogenetics? | [
{
"ade": "Epstein-Barr virus-associated lymphoproliferative disorder",
"drug": "methotrexate"
},
{
"ade": "Epstein-Barr virus-associated lymphoproliferative disorder",
"drug": "rofecoxib"
}
]
|
A 50-year-old woman with a history of migraine without aura, predominantly occurring around her menstrual periods, developed a spinal cord lesion following the use of zolmitriptan. | [
{
"ade": "spinal cord lesion",
"drug": "zolmitriptan"
}
]
|
Data have been published regarding the possibility that tamoxifen may be responsible for the subsequent development of carcinoma of the corpus uteri in these patients. | [
{
"ade": "carcinoma of the corpus uteri",
"drug": "tamoxifen"
}
]
|
Pulmonary gold toxicity. | [
{
"ade": "Pulmonary gold toxicity",
"drug": "gold"
}
]
|
We present two children with acute lymphocytic leukemia who developed leukoencephalopathy following administration of a combination of intravenous ara = C and methotrexate during the consolidation phase of chemotherapy. | [
{
"ade": "leukoencephalopathy",
"drug": "ara = C"
},
{
"ade": "leukoencephalopathy",
"drug": "methotrexate"
}
]
|
BACKGROUND: Hypersensitivity reactions to cyclosporine are rare. | [
{
"ade": "Hypersensitivity reactions",
"drug": "cyclosporine"
}
]
|
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