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Ans. is b i.e. Estrous Estrous : It is cyclical period of sexual activity in non human female mammals, marked by congestion of and secretion by the uterine mucosa, proliferation of vaginal epithelium, swelling of the vulva, ovulation, and acceptance of the male by the female. During estrus, the animal is said to be "in heat". Also Know 7 Estrus cycle - The sequence from the beginning of one estrus period to the beginning of the next. It includes : * Proestrus Estrus Metestrus followed by Diestrus (period of quiescence).
Gynaecology & Obstetrics
null
In those mammals which are seasonal breeder, the females are receptive only once in a year ; the cycle is termed as : A. Follicular B. Estrous C. Menstrual D. Luteal
Estrous
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Epiphysio-diaphyseal joint is a primary cartilaginous joint – synchondrosis. It is found in the growing bone, where the growth plate (hyaline cartilage) connects the epiphysis with the diaphysis, creating a hyaline cartilaginous joint. At this site the fate of synchondrosis is synostosis (bony fusion) after the growth plate gets removed and replaced by the bone.
Anatomy
null
Joint between epiphysis and diaphysis of a long bone is a type of: A. Plane Synovial joint B. Fibrous joint C. Symphysis D. Synchondrosis
Synchondrosis
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Ans. is 'd' i.e., Diaphragm Respiratory musclesInspiratory muscles1. During quiet breathing : Diaphragm (most important), external intercostal and interchondral part of internal intercostal.2. During forced inspiration : Sternocleidomastoid, serratus anterior, serratus posterior superior, pectoral is major and minor, erector spinae, scaleni and levator costarum.Expiratory' muscles1. During quiet breathing : Passive process due to passive recoil of the lungs and thoracic wall.2. During forced expiration : Internal intercostal, innermost intercostal, transversus thoracis, serratus posterior inferior, subcostalis, lattissimus dorsi and abdominal muscles (rectus abdominis, internal and external oblique and transversus abdominis).
Anatomy
Thorax
Main inspiratory muscle is - A. Lattissimus dorsi B. Transversus thoracis C. Serratus anterior D. Diaphragm
Diaphragm
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According to Kim et al Classification; there are 5 types Type I incomplete isthmus between 2 canals. Type II well defined, complete isthmus between 2 canals. Type III very short but complete isthmus between 2 canals. Type IV 3 or more canals with the complete or incomplete isthmus. Type V 3 or more canals without any visible connection.
Dental
null
Kim et al classification system deals with: A. Apical constriction B. Apical foramen C. Isthmus D. No. of canals
Isthmus
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Peussis is an acute highly contagious respiratory tract infection caused by Bordetella peussis. Extremely contagious and clinical presentation can be divided into 3 stages like catarrhal, paroxysmal and convalescent It is called whooping cough due to the characteristic whoop produced by the air rushing in during inspiration through half open glottis. - diagnosis is mainly based on clinical symptoms. - the sample of choice is nasopharyngeal swab. Reference : Ghai essential pediatrics, 9 th edition, pg no:237
Pediatrics
Infectious disease
A child presents with recurrent bouts of severe cough followed by an audible whoop. Which of the following is considered the best type of specimen to isolate the organism and confirm the diagnosis A. Nasopharyngeal swab B. Cough plate C. Throat Swabs D. Anterior Nasal Swab
Nasopharyngeal swab
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Ans. is 'b' i.e.. Charge Property of protein usedMethodProtein solubility'Salting out' or salt extraction (precipitation of protein by ammonium sulfate)Molecular sizeo Gel filtration chromatography (molecular-sieve chromatography or size exclusion chromatography)o Ultracentrifugationo SDS-PAGE (Sodium dodecvl sulphate-polyacry lamide gel electrophoresis)o DialysisMolecular charge (Ionic charge)o Ion exchange chromatographyo High performance liquid chromatography (HPLC)o Electrophoresis (simple on cellulose acetate starch gel)o Isoelectric focusing (a variant of electrophoresis)Molecular charge and molecular w eightPAGE : polyacrylamide gel electrophoresisAffinity bindingAffinity chromatographyHvdnophobidty'Hydrophobic interaction chromatography
Biochemistry
Miscellaneous (Structure & Function of Proteins)
Ion exchange chromatography is based on - A. Size B. Charge C. Solubility D. Polarity
Charge
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In Hansen&;s disease ,the earliest sensation to be affected is usually light touch. Reference; Park&;s Textbook of preventive and social medicine, 24th edition.Pg no. 332
Social & Preventive Medicine
Communicable diseases
Earliest sensation to be lost Hansens disease is - A. Pain B. Touch C. Vibration D. Temperature
Touch
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Basal ganglia The most common sites of hypeensive haemorrhage are: The basal ganglia (putamen, thalamus and adjacent deep white matter) Deep cerebellum Pons
Surgery
null
Most common site of intracranial hemorrhage in hepeensive hemorrhage is : A. Basal ganglia B. Brain.stem C. Cerebellum D. Hippocampus
Basal ganglia
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The basic molecular defect in Down's syndrome is the extra genetic material of chromosome 21. It may be due to : 1) Trisomy 21 This is the most common cause (95%). There is an extra chromosome 21 (i.e. three 21 chromosomes) which is due to meiotic nondisjunction in the ovum. The extra chromosome is of maternal origin. The most important risk factor is advanced maternal age (> 35 years). 2) Roberston translocation This accounts for 3% of cases. Extra material of 21 chromosomes comes from Robertson translocation of the long arm of chromosome 21 to another acrocentric chromosome (22, or 14 or 15), i.e. t (22: 21), t (14:21), or t (15:21). It has no relation with maternal age. 3) Mosaicism (Mosaic 21) In 2% of patients, there is mosaicism, i.e. occurrence of two or more different types of the cell population (46 XX / 47 XX + 21) in the same individual, due to mitotic nondisjunction of chromosome 21. There is no correlation with maternal age. 4) Partial trisomy It is very very rare. The long arm of chromosome 21 triplicates
Pediatrics
null
Which mutation is seen in Down’s syndrome - A. Monosomy X B. Trisomy 21 C. Trisomy 22 D. Trisomy 22
Trisomy 21
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Dynamic hip screw (DHS) plate is the implant of choice for fixation. These days proximal femoral nail (PFN) is also commonly used.
Orthopaedics
null
Trochanteric fracture of the femur is best treated by - A. Dynamic hip screw B. Inlay plates C. Plaster in abduction D. Plaster in abduction and internal rotation
Dynamic hip screw
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Phenylalanine It is an alpha-amino acid. This essential amino acid is classified as nonpolar because of the hydrophobic nature of the benzyl side chain. L-Phenylalanine (LPA) is an electrically neutral amino acid The codons for L-phenylalanine are UUU and UUC. Phenylalanine is a precursor for tyrosine, the monoamine signaling molecules dopamine, norepinephrine (noradrenaline), and epinephrine (adrenaline), and the skin pigment melanin.
Biochemistry
null
Essential amino acid is: A. Phenylalanine B. Proline C. Glutamine D. Serine
Phenylalanine
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Savlon is a very popular disinfectant in the hospitals and it contains chlorhexidine and cetrimide.
Pharmacology
null
Savlon contains : A. Cetrimide and cetavlon B. Cetrimide and Chlorhexidine C. Cetrimide, Chlorhexidine and butyl alcohol D. Cetrimide and butyl alcohol
Cetrimide and Chlorhexidine
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In stapedial palsy, damage to the nerve result in a reduction in sound attenuation reflex resulting in sound being heard excessively loud in the affected ear (hyperacusis). Attenuation reflex: When very loud sound is transmitted through the ossicular system to CNS a reflex is initiated with a latent period of 40 to 80ms. This reflex causes contraction of tensor tympani and stapedius muscle. Contraction of these two muscles make the ossicular system rigid and therefore it fails to vibrate with the sound wave. Thus sound is not allowed to enter inner ear or its intensity is reduced by 30 to 40 decibels.
ENT
null
Which of the following condition is associated with a loss of attenuation reflex? A. Stapedial palsy B. Glomus tumor C. Internal ear pathology D. Malingerers
Stapedial palsy
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The health care provider may hear a fast heabeat while listening to your hea with a stethoscope. Your pulse may feel fast, uneven, or both. The normal hea rate is 60 to 100 beats per minute. In atrial fibrillation or flutter, the hea rate may be 100 to 175 beats per minute Digoxin toxicity is a life-threatening condition. ... The classic arrhythmias seen during digoxin toxicity include atrial tachycardia with a 2:1 conduction, bidirectional ventricular tachycardia and atrial fibrillation with a slow ventricular response Ref Harrison 20th edition pg 1436
Medicine
C.V.S
In a patient with chronic atrial fibrillation with a regular beat of 60/min, the most probable cause is- A. Sleep B. Digitalis toxicity C. Sino nodal block D. Hypothyroidism
Digitalis toxicity
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Proper identification of the biopsy site is of paramount impoance. To choose the site, sta with percussion over the right upper quadrant. The biopsy site is usually located in the seventh or eighth intercostal space in the midaxillary line. The site can be fuher confirmed with either routine ultrasonography or a bedside poable ultrasound machine. be sure to eliminate the possibility of bowel juxtaposition along the biopsy tract. Ref Davidson edition23rd pg864
Medicine
G.I.T
What is the uppermost intercostals space used for hepatic biopsy - A. 7th B. 10th C. 5th D. 9th
7th
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Ans. b (Ibuprofen). (Ref. KDT 6th/pg. 191)AnalgesicPropertiesNimesulideDue to gastrointestinal, dermatological, renal & fulminant hepatic failure side effects, its safety, especially in children is questional. Banned in USA.IbuprofenSafest conventional NSAID.But should not be prescribed to pregnant women & peptic ulcer disease patients.ParacetamolIt has negligible anti-inflammatory action.HepatotoxicDiclofenacanalgesic-antipyretic anti-inflammatory drug is Ulcerogenic
Pharmacology
Miscellaneous (Pharmacology)
Anti-inflammatory drug that can safely be used in children is A. Paracetamol B. Ibuprofen C. Diclofenac D. Nimesulide
Ibuprofen
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Exclusive breastfeeding advised for 4-6months of age.(Refer: OP Ghai's Textbook of Pediatrics, 8th edition, pg no. 60, 122)
Pediatrics
All India exam
Exclusive breastfeeding is advised till what age? A. 3 months B. 6 months C. 9 months D. 10 months
6 months
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Pulmonary aery pressures are reflective of RV pressures .Pulmonary circulation is low pressure, low resistance circulation as compared to systemic circulation. Pulmonary vessels are about 24 times more compliant compared to their systemic counterpas. Pulmonary circulation, in a sho route, has to accommodate large quantities of blood. Due to their high compliance and large amounts of blood accommodated within them, lungs are called 'reservoir of blood'. At any given time, lungs accommodate about 15% of the total blood volume.
Physiology
Respiratory System
The characteristic of the pulmonary circulation: A. High resistance, high compliance B. Low resistance, low compliance C. High resistance, low compliance D. Low resistance, high compliance
Low resistance, high compliance
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(Ref: Katzung 11/e p942) The patient described in the question has henorrhagic cystitiws caus3d by drugs like cyclophosphamide and ifosfamide. Hemorrhagic cystitis during therapy with cyclophosphamide or ifosfamide is caused by the urinary excretion of the toxic metabolite acrolein. This can be preventede by aggressive hydration, bladder irrigation, and administration of mesna, a sulfhydryl compound that binds acroleinin the urine.
Pharmacology
Other topics and Adverse effects
Roopa Devi, a 65-year-old female with lymph-node-positive breast cancer was treated with systemic chemotherapy. Four weeks later, she developed frequent urination, suprapubic pain, dysuria, and hematuria. Which of the following could have prevented this patient's condition? A. Folinic acid B. Mesns C. Dexrazoxane D. Amifostine
Mesns
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(b) Glossopharyngeal(Ref. Scott Brown, 8th ed., Vol 2 page 535)The sensory supply of the middle ear is by the tympanic plexus which is formed by the Jacobson's nerve which is the tympanic branch of Glossopharyngeal (IX) along with sympathetic plexus from around the internal carotid.
ENT
Ear
Sensory nerve supply of middle ear cavity is provided by: A. Facial B. Glossopharyngeal C. Vagus D. Trigeminal
Glossopharyngeal
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Testicular Biopsy in Male Infeility The testis biopsy provides direct information regarding the state of spermatogenesis Abnomalities of seminiferous tubules architecture and cellular composition are then categorized into several patterns. This procedure is most useful in the azoospermia patient, in which it is often difficult to distinguish between a failure of sperm production and obstruction within reproductive tract ducts. A testis biopsy allows definitive delineation between these 2 conditions and can guide fuher treatment options in azoospermic men. Testis biopsies may also be indicated to identify patients at high risk for intratubular germ cell neoplasia. This premalignant condition exists in 5% of men with a contralateral germ cell tumour of the testis and is more prevelent in infeile than feile men. Ref: Smith 18th edition Pgno: 699
Surgery
Urology
Best indication foe testicular biopsy in male is: A. Polyspermia B. Oligospermia C. Necrospermia D. Azoospermia
Azoospermia
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The work of Goldman and others has served to identify risk factors for perioperative myocardial infarction. The highest likelihood is associated with recent myocardial infarction: the more recent the event, the higher the risk up to 6 months. It should be noted, however, that the risk never returns to normal. A non-Q-wave infarction may not have destroyed much myocardium, but it leaves the surrounding area with borderline perfusion, thus the paicularly high risk of subsequent perioperative infarction. Evidence of congestive hea failure, such as jugular venous distention, or S3 gallop also carries a high risk, as does the frequent occurrence of ectopic beats. Old age (>70 years) and emergency surgery are risk factors independent of these others. Coronary revascularization by coronary aery bypass graft (CABG) tends to protect against myocardial infarction. Smoking, diabetes, hypeension, and hyperlipidemia (all of which predispose to coronary aery disease) are surprisingly not independent risk factors, although they may increase the death rate should an infarct occur. The value of this information and data derived from fuher testing is that it identifies the patient who needs to be monitored invasively with a systemic aerial catheter and pulmonary aerial catheter. Most perioperative infarcts occur postoperatively when the third-space fluids return to the circulation, which increases the preload and the myocardial oxygen consumption. This generally occurs around the third postoperative day.
Anaesthesia
Preoperative assessment and monitoring in anaesthesia
A 78-year-old man with a history of coronary aery disease and an asymptomatic reducible inguinal hernia requests an elective hernia repair. Which of the following would be a valid reason for delaying the proposed surgery? A. Coronary aery bypass surgery 3 months earlier B. A history of cigarette smoking C. Jugular venous distension D. Hypeension
Jugular venous distension
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Haem iron is present in liver, meat, poultry, and fish. Non haem iron is present in green leafy vegetable,jaggery and dry fruit. REF. PARK'S TEXTBOOK OF PREVENTIVE AND SOCIAL MEDICAL 21ST EDITION. PAGE NO - 623
Social & Preventive Medicine
Nutrition and health
Among the following, which one is not good dietary source of iron - A. Liver B. Jaggery C. Fish D. Milk
Milk
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The fold in collagen is because of presence of Glycine. ADDITIONAL READING ON STRUCTURE OF COLLAGEN: Collagen is made up of 3 alpha- chains (not alpha helix). These 3 chains together make a superhelix --> Tropocollagen(a rope like triple helix) Superhelix (right handed) is oured by Glycine residues. Glycine has the smallest side chain soit fits into the restricted space where three chains of helix come together.
Biochemistry
Glycine Metabolism Detail
The fold in collagen is because of presence of: A. Histidine B. Glycine C. Argininc D. Glutamate
Glycine
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Emphysematous pyelonephritis (EPN) is a severe, necrotizing infection of the renal parenchyma causing gas formation within the collecting system, renal parenchyma, and/or perirenal tissues. Also called renal emphysema and pneumonephritis. Gas in the renal pelvis alone, without parenchymal gas, is often referred to as emphysematous pyelitis.EPN most often occurs in persons with diabetes mellitus, especially women.Among the bacteria associated with emphysematous pyelonephritis (EPN), Escherichia coli is isolated in 66% of patients, and Klebsiella species are repoed in 26% of patients. Proteus,Pseudomonas, and Streptococcus species are other organisms found in patients with EPN, and Entamoeba histolytica and Aspergillus fumigatus also have been repoed to cause the disease. Mixed organisms are observed in 10% of patients. Rare organisms such as Clostridium and Candida species have also been isolated in patients with EPN.
Surgery
Urology
The common organism isolated in Emphysematous pyeloneohritis is A. E. Coli B. Proteus C. Pseudomonas D. Klebsiella
E. Coli
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Oxalate crystals in urine is seen with Ethylene Glycol poisoning. Renal pain and acute tubular necrosis in it, occurs due to renal calcium oxalate precipitation. Other features includes, opthalmoplegia, cranial nerve palsies, hyporeflexia and myoclonus Reference: Harrison20th edition pg pg 789
Medicine
Toxicology
Oxalate crytals in urine is seen in - A. Ethylene glycol poison B. Di glycol poison C. Alcohol D. Indivavir
Ethylene glycol poison
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Majority of HIV transmission occur during labour (40-80%). Perinatal transmission of HIV: Veical transmission of HIV to the neonate is about 14 - 25%. Transmission of HIV 2 is less frequent (1-4%) than HIV 1(14-35%). Veical transmission of HIV is more in cases with preterm bih and with prolonged membrane rupture. Risk of veical transmission is directly related to maternal viral load and inversely to maternal immune status. Maternal anti retro viral therapy reduces the risk of veical transmission by 70%. Breast feeding increases HIV 1 transmission by 14%. Ref: Textbook of Obstetrics By D.C Dutta, 6th edn, page 300.
Gynaecology & Obstetrics
null
An HIV positive patient is pregnant. During which of the following stage is HIV transmission maximum? A. Labour B. Early pregnancy C. Late pregnancy D. Post delivery
Labour
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Metastable REF: Nuclear Physics: Principles And Applications by Lilley Page 20 "In 99Tcm the superscript M denotes that the technetium 99 is not in its ground state but a long lived metastable excited state"
Radiology
null
M in 99Tc"' stands for? A. Micro B. Mega C. Metastable D. Metastatic
Metastable
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Ans. is 'c' i.e., CPKCreatinine phosphokinase (CK) Previously It was the gold standard marker of acute Ml.o But now it has largely been replaced by troponin T and I (see above explanation).o But, CK remains the best alternative to troponin measurement.CK-MB isotype of this enzyme is specific for myocardium.It is raised within 2-4 hours after MI, peaks at 24 hours and returns to normal within approximately 72 hours.
Pathology
null
In MI, which enzyme is raised in 4 to 6 hrs and decreases in 3 to 6 days - A. SGOT B. LDH C. CPK D. SGOT
CPK
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The normal free copper value is 10-15 mcg/dL and it is often as high as 50 mcg/dL in untreated Wilson's disease. With treatment, free copper should be <25 mcg/dL. Reference: Harrisons Principles of Internal Medicine, 18th Edition, Page 3190
Medicine
null
During treatment for Wilson disease with trientine and penicillamine, free serum copper should be kept below which level? A. 25 mcg/dl B. 50 mcg/dl C. 75 mcg/dl D. 100 mcg/dl
25 mcg/dl
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Individual type of nerve differs in their minimal blocking concentration. Not all sensory and motor modalities are blocked equally by local anesthetics. This is termed differential blockade. For different fibers order of blockade b > AS = C > AU > A b > Aa autonomic > sensory> motor is the sequence of block. for sensory blockade the sequence is Temperature - pain - touch - pressure
Anaesthesia
Regional Anesthesia
The order of sensory blockade of local anesthesia is: A. Temperature - pain - touch - pressure B. Pain - pressure - touch - temperature C. Touch - pressure - temperature - pain D. Touch - pain - pressure - temperature
Temperature - pain - touch - pressure
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Adult pateint presenting with generalized lymphadenopathy and blood film shows 70percent immature looking lymphocytes is highly suggestive of chronic lymphocytic leukemia. Immunophenotyping can be one of the best ways to differentiate between CLL and other B cell neoplasms.( ref Robbins 9/e p593)
Anatomy
Haematology
Adult patient presents with generalized lymphadenopathy and blood film shows 70percent immature looking lymphocytes. What should be the next best investigation? A. Genotyping/karyotyping B. Immunophenotyping C. Bone marrow D. Peripheral smear study
Immunophenotyping
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Ans. c. Diazepam (Ref: Niraj Ahuja 6th/39-40; Kaplan Synopsis 10th/396)'Long acting benzodiazepines such as chlordiazepoxide and diazepam or short acting such as lorazepam can be used to treat mild-moderate uncomplicated alcohol withdrawal.''Chlordiazepoxide is preferred over diazepam for treatment of alcohol withdrawal syndrome.'Management ofAlcohol IntoxicationAlcohol WithdrawalDelirium TremensDrugs used are:* Lorazepam (can worsen the vitals due to CNS depression)* Haloperidol (can lower seizure threshold)Other drugs which may be used:* Ziprasidone* Olanzapine* All patients should be given multiple oral vitamin B1 including 50-100 mg of thiamine daily for a week.* Replace alcohol (CNS depressant) with any other CNS depressant.* Benzodiazepines are commonly used.* Chlordiazepoxide is drug of choice because of its long half-life.* High dose benzodiazepines or antipsychotics are recommended.* Anticonvulsants are not given to control seizures seen in delirium tremens.
Psychiatry
Alcohol-Related Disorders
A known alcoholic is brought to the emergency department by his wife. The person has not consumed alcohol for the past two days due to religious reasons. The person complained of nausea, vomiting and dizziness. On the second day, he developed seizures, that progressed to generalized tonic clonic seizures (GTCs). Which of the following would be the best medication to manage the seizures of the patients? A. Sodium valproate B. Phenytoin C. Diazepam D. Clonidine
Diazepam
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BRACHIAL PLEXUS INJURIES It can be: Supraclavicular injury 65% Infraclavicular injury 25% Combined 10% It can also be: Upper plexus injury. Lower plexus injury. It can be: Pre-ganglionic injury Post-ganglionic injury Avulsion injury Usually less severe More dangerous Better recovery Extends into the spinal cord Upper plexus injury (Erb's Duchenne paralysis) Lower plexus injury (Klumpke's paralysis) It is due to depression of shoulder by trauma After diffucult labour in newborn. Here C5 and C6 roots are injured Muscles affected are deltoid, biceps, brachioradialis & supinator Effects Elbow will be extended, pronated & upper limb is internally rotated (Policemen receiving tip) Sensory deficit over the lateral aspect of arm & upper pa of the lateral forearm Forcible hyperabduction of shoulder causes thr injury In newborn it results due to difficult breech delivery Here C8 & 51 are injured Intrinsic muscles of hand are involved Effects Combines Median & Ulnar claw hand Horner's syndrome Sensory deficit over the medial aspect of forearm, hand & medial 1 1/2 finger Investigations Nerve conduction studies. CT/MRI. Electromyogram. X-ray cervical spine and pa. Treatment Conservative, nerve repair. Tendon transfer, physiotherapy. Osteotomy of coracoid process proximal to the attachment of pectoralis minor, sho head of biceps and coracobrachialis is done to improve abduction--Sever's operation. Ref: SRB's Manual of Surgery 5th edition Pgno : 265
Surgery
Trauma
A 45 year-male presents with abrupt onset pain, weakness, loss of contour of shoulder and muscle wasting on 5th day of tetanus toxoid immunization. Likely cause is A. Hysterical B. Radial nerve entrapment C. Brachial plexus neuritis D. Thoracic outlet syndrome
Brachial plexus neuritis
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Answer- A. Chylomicrons White (Lactescent) appearance is caused by chylomicrons.
Medicine
null
A patient undergoes a lipid profile screening. On withdrawing the blood, it appears white in colour, Which of the following is the most probable elevated lipoprotein? A. Chylomicrons B. HDL C. LPL D. Cholesterol
Chylomicrons
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Temperature is the first sensation that is lost. The next sensation lost is light touch then pain. Deep pressure is lost finally.
Dental
null
Earliest sensation to be lost in Hansens disease is – A. Pain B. Touch C. Vibration D. Temperature
Temperature
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SURFACE ECTODERM - LENS- Epithelium of the all structures except ciliary body & iris- Glands NEURAL ECTODERM - Epithelium of ciliary body & iris- Retinal pigment epithelium- Optic nerve- Sphincter and dilator pupillae muscles - Smooth muscles of iris MESODERM - EXTRAOCULAR MUSCLES- Endothelium of all the orbit & stroma of iris & ciliary body- Sclera (temporal pa) NEURAL CREST - Stroma of cornea & choroid - Corneal endothelium - Sclera (except temporal pa) -Melanocytes -Corneal keratocytes -Ciliary muscles -Ciliary ganglion -Stroma of iris -Choroid Trabecular meshwork
Ophthalmology
Ocular Embryology& Anatomy
Corneal endothelium is derived from: A. Neuroectoderm B. Neural crest cells C. Mesoderm D. Surface ectoderm
Neural crest cells
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(d) Adenoidectomy with grommet insertion(Ref. Scott Brown, Vol 2; 288)Recurrent URTI with mouth breathing and failure to thrive in the given 6-year-old child with high arched palate is due to persistently hypertrophied adenoids.The impaired hearing is due to serous otitis media which in turn is because of hypertrophied adenoids blocking the Eustachian tubes.So treatment will be adenoidectomy with grommet insertion.
ENT
Ear
Management of a 6-year-old child with recurrent URTI with mouth breathing and failure to thrive with high arched palate and impaired hearing is: A. Tonsillectomy B. Grommet insertion C. Myringotomy with grommet insertion D. Adenoidectomy with grommet insertion
Adenoidectomy with grommet insertion
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Bipolar disorder earlier known as manic-depressive psychosis is characterised by recurrent episodes of mania and depression in the same patient at different times. These episodes can occur in any sequence. (Ref: a sho textbook of psychiatry, NirajAhujaa, 7th edition, pg no.73)
Psychiatry
Mood disorders
What is affected in bipolar disorder A. Emotions B. Perception C. Personality D. Thought
Emotions
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Hydralazine, procainamide, isoniazid and penicillamine are most commonly associated with drug induced lupus. The list of substances that can induce lupus-like disease is long. Among the most frequent are: Antiarrhythmic, procainamide, disopyramide, and propafenone Antihypeensive: hydralazine; several angiotensin-conveing enzyme inhibitors and beta blockers Antithyroid: propylthiouracil Antipsychotics: chlorpromazine and lithium Anticonvulsants: carbamazepine and phenytoin Antibiotics: isoniazid, minocycline, and macrodantin Antirheumatic: sulfasalazine Diuretic: hydrochlorothiazide Antihyperlipidemics: lovastatin and simvastatin Interferons and TNF inhibitors
Pharmacology
null
A patient given one of the following drug develops low grade fever, muscle and joint ache, chest pain and skin rashes. Lab investigations showed presence of antihistone antibodies. Symptoms however subsided after discontinuation of the drug. Which is the drug that caused the reaction? A. Hydralazine B. Rifampicin C. Paracetamol D. Furosemide
Hydralazine
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GLOMUS TUMOUR, also called as glomangioma, arises from the cutaneous glomus composed of a touous aeriole which communicates directly into the venule (Sucquet-Hoyer canal) and these vessels being surrounded by network of small nerves making this lesion very painful. It consists of a mixture of blood spaces, nonmedullated nerve tissue, muscle fibres derived from the wall of the aeriole, with large cuboidal glomus cells--angiomyoneuroma. They are often seen in limbs and common in nail-beds near the finger tips, as purple red swelling. Excision cures the condition. Reference : page 81 SRB'S manual of surgery 5th edition
Surgery
Urology
Glomus tumor is seen in A. Liver B. Adrenals C. Pitutary D. Finger
Finger
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Complicated lesions indicate advanced atherosclerotic disease. They arise in atherosclerotic plaques, and render them more susceptible to sudden occlusion and acute infarction of the supplied tissues. Commonly, the plaque ulcerates or ruptures, and the exposed surfaces, being highly thrombogenic, precipitate thrombus formation. Thrombi are typified by the lines of Zahn, alternating layers of platelets and fibrin (the pale lines) and layers of blood (the dark lines). Beyond thrombus formation, other features of a complicated plaque include hemorrhage into the lesion itself, and microembolism by cholesterol crystals or calcified debris. Fuhermore, the weakened media underlying the plaque may develop an aneurysmal dilatation. In general, the clinical significance of atherosclerosis is related to the consequences of complicated lesions. The incorrect options all include features of atheromatous plaques, but do not indicate complicated lesions:Beneath the endothelium of a plaque there is a fibrous cap composed of smooth muscle, chronic inflammatory cells and lipid laden macrophages (foam cells), as well as extracellular material. The core of the lesion, which lies between the intima and the media, is composed of necrotic cellular debris, with cholesterol crystals, calcium, and more foam cells. Ref: Fuster V., Falk E. (2011). Chapter 52. Atherothrombosis: Disease Burden, Activity, and Vulnerability. In V. Fuster, R.A. Walsh, R.A. Harrington (Eds),Hurst's The Hea, 13e.
Pathology
null
The presence of which of the following features in an atherosclerotic plaque indicates that it has become a complicated lesion? A. Cholesterol crystals B. Chronic inflammatory cells C. Intimal smooth muscle D. Lines of Zahn
Lines of Zahn
b18fd6a8-d9f1-4638-abaa-e256c76920d9
Testicular lymphoma is the most common testicular tumor in patients older than 60 years.
Pathology
null
Which is the most common testicular tumor in patients older than 60 years? A. Seminoma B. Leydig cell tumor C. Teratoma D. Lymphoma
Lymphoma
cb0c7ff4-2cc8-472e-a56d-8a8815ba7076
Complete interruption of the median nerve results in inability to pronate the forearm or flex the hand in a radial direction, paralysis of flexion of the index finger and terminal phalanx of the thumb, weakness of flexion of the remaining fingers, weakness of opposition and abduction of the thumb in the plane at a right angle to the palm (abductor and flexor pollicis brevis), and sensory impairment over the radial two-thirds of the palm and dorsum of the distal phalanges of the index and third fingers. The nerve may be injured in the axilla by dislocation of the shoulder and in any pa of its course by stab, gunshot, or other types of wounds, and like the radial nerve, is often a component of the mononeuritis multiplex syndrome. Ref : Samuels M.A. (2009). Chapter 46. Diseases of the Peripheral Nerves. In M.A. Samuels (Ed), Adams and Victor's Principles of Neurology, 9e.
Surgery
null
Pointing finger is due to injury to which nerve? A. Median B. Radial C. Ulnar D. Axillary
Median
691f500f-f0f6-4dc2-bdf5-877f0cf14c34
Fibromatosis is a group of fibroblastic proliferation distinguished by their tendency to grow in an infiltrative fashion and in many cases intend to recover after surgical removal. They can be isolated lesions or as a component of Gardner syndrome, an autosomal dominant disorder. Hence we can conclude that fibromatosis is an autosomal hyperplasia. Robbins basic pathology 9th edition page no, 793
Pathology
miscellaneous
Autonomous hyperplasia is seen in- A. Choristoma B. Endometrial hyperplasia C. Fibromatosis D. Hamaoma
Fibromatosis
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FSs are ectopic sebaceous glands seen commonly on the lips (upper lip > lower lip), buccal, and genital mucosa. Infrequently, they can also be seen on oesophagus, uterine cervix, sole of the foot, and tongue. Histopathologically, a FS consists of a sebaceous lobule or gland located in the dermis. The Dermoscopy of FS on the penile shaft has been described and it shows vascular "garlands-like" aspect whose "bows" seem to wind around yellowish bunch-like lobules without crossing them iadvl textbook of dermatology
Dental
Bacterial infections
Fordyce disease most commonly effects A. Lips B. Neck C. Buccal mucosa D. Trunk
Lips
cc367b2d-15dc-4b26-aba8-9aaa6c69c740
Type Name Enzyme Deficiency Clinical Features IV Amylopectinosis, Andersen disease Branching enzyme Hepatosplenomegaly Accumulation of polysaccharide with few branch points Death from hea or liver failure before age 5 Reference: Harper; 30th edition; Table: 18-2; Page no: 179
Biochemistry
Metabolism of carbohydrate
Branching enzyme deficiency is seen in A. Andersen disease B. McArdle's syndrome C. Cori disease D. Von Gierke disease
Andersen disease
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Ans. is 'b' Goodpasture syndrome Goodpasture syndromeGoodpasture syndrome is a rare condition characterized by rapid destruction of the kidney and diffuse pulmonary hemorrhage.It is an autoimmune disease characterized by presence of circulating autoantibodies targeted against basement membrane of lung and kidney.These antibodies are directed against the noncollagenous domain of the a-3 chain of type IV collegen (collegen of basement membrane).The antibodies initiate an inflammatory destruction of the basement membrane in kidney glomeruli and lung alveoli.In Goodpasture syndrome, immune reaction is type II hypersensitivity.Morphological changesLungThe lungs are heavy, with areas of red brown consolidation.There is focal necrosis of alveolar walls associated with intraalveolar hemorrhages. Alveoli contain hemosiderin-laden macrophages.Linear deposits of immunoglobulins along the basement membranes of the septal walls.KidneyDiffuse proliferative rapidly progressive glomerulonephritis.Focal necrotizing lesion and crescents in >50% of glomeruli.Linear deposits of immunoglobulins and complement along glomerular basement membrane.Clinical manifestationsOccur typically in young males.Most cases begin clinically with respiratory symptoms, principally hemoptysis.Soon, manifestations of glomerulonephritis appear and typically present as nephritic syndrome - hematuria, nephritic urinary sediment, subnephrotic proteinuria, rapidly progressive renal failure.The common cause of death is renal failure.
Pathology
null
Alveolar hemorrhage and hemosiderin laden macrophages ? A. Sarcoidosis B. Goodpasture syndrome C. Bronchial pneumonia D. Bronchieactasis
Goodpasture syndrome
4ff6db83-2049-4da9-9bb0-56eb6a8db6db
(Biparietal diameter) (85-Dutta 6th)Real ultrasound measurement of fetal growth* First trimester - Crown - rump length* Second trimester - Biparietal diameter (BPD)* Third trimester - Multiple foetal growth parameters are considered together. These are- Prior to 36 weeks - Combination of biparietal diameter, abdominal circumference and femur length (FL)- After 36 weeks - Combination of head circumference, abdominal circumference and femur lengthA- BPD greater than 9.2 cm indicates foetal pulmonary maturity corroborated by L:S ratio* Early measurement of BPD and FL are the most useful in establishing gestational age Later measurement of fetal growth are best achieved by measurement of the head circumference and the abdominal circumference (G. chamberlain 7th)* Foetal head: abdominal circumference ratioMaximum - 1.29 at 12 weeksEqual - 1.00 at 36 weeksMinimum - <1.00 after 37 weeks* Bishop score is used for induction of labour* Manning score is most sensitive & reliable test for fetal well beingDifferent diameter of skull in newborn are* Suboccipito-bregmatic =9.5cm* Suboccipito-frontal =10cm* Occipito frontal =11.5cm* Mento vertical =14cm* Sub mento vertical =11.5cm* Sub mento-bregmatic =9.5cm* Biparietal diameter =9.5cm* Super-subparietal =8.5cm* Bitemporal diameter =8cm* Bimastoid diameter =7.5cm* Twin peak sign - Ultrasonography shows extension of placental tissue into the inner twin membrane in diaminiotic dichorionic (DD)
Gynaecology & Obstetrics
Miscellaneous (Gynae)
Most sensitive test for assessment of fetal well being is A. Biparital diameter B. Arm circumference C. Abdominal circumference D. Head circumference
Biparital diameter
d3383de9-1c50-419c-8b93-d02f4e489f53
Ans. is 'a' i.e., Parotid gland STENSONDUCTPAROTID GLANDThe exit of the parotid ducts can be felt as small bumps (Papillae) on both sides of the mouth, and are usually positioned next to the maxillary second molars.WHARTONDUCTSUBMANDIBULARGLANDIt then passes between the sublingual gland and the genioglossus and opens by a narrow opening on the summit of a small papilla at the side of the frenulum of the tongue.
ENT
Oral Cavity
A 53 year old male man cpmplains of pain around his cheek and neck. On examination there is pus pouring out from his Stenson's duct. Which gland is involved? A. Parotid gland B. Submandibular gland C. Sublingual Gland D. Lacrimal Gland
Parotid gland
37ed1d81-d3c0-4940-95f2-f627c4ec8d7a
Lacrimal sac cyst occurs as a compressible swelling near the medial canthus and not root of nose. Ethmoid cyst (mucocele) presents as a swelling at the medial quadrant of orbit pushing the orbit forwards and laterally. AV malformation is a congenital abnormal connection between aeries and veins, bypassing the capillary system.These are largely found in internal organs and is rare at this site.
ENT
null
A 2 year old child is brought to the hospital with a compressible swelling at the root of nose, most likely diagnosis is: A. A V malformation B. Lacrimal sac cyst C. Ethmoid sinus cyst D. Meningoencephalocele
Meningoencephalocele
75aa19b1-3db5-4c15-b950-c9a8d9c269ca
Formaldehyde gas is used for sterilizing instruments and heat sensitive catheters and for fumigating wards, sick rooms and laboratories. Under properly controlled conditions, clothing, bedding, furniture, and books can be satisfactorily disinfected. In aqueous solutions, it is markedly bactericidal and sporicidal and also lethal effect on viruses. Ref: Textbook of Microbiology By Ananthanarayan, 6th edition, Page 29.
Microbiology
null
Wards in an hospital are sterilized by the following method: A. Ethylene oxide gas B. Formaldehyde fumigation C. Washing with soap water D. Carbolic acid spraying
Formaldehyde fumigation
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(C) Perforated peptic ulcer # Clinical features Perforated peptic ulcer:> The classic presentation is instantly recognizable. The patient, who may have a history of peptic ulceration, develops sudden- onset, severe, generalized abdominal pain as a result of the irritant effect of gastric acid on the peritoneum.> Although the contents of an acid-producing stomach are relatively in bacterial load, bacterial peritonitis supervenes over a few hours, usually accompanied by a deterioration in the patient's condition.> Initially, the patient may be shocked with a tachycardia but a pyrexia is not usually observed until some hours after the event.> The abdomen exhibits a board-like rigidity and the patient is disinclined to move because of the pain.> The abdomen does not move with respiration.> Patients with this form of presentation need an operation, without which they will deteriorate with a septic peritonitis.
Surgery
Miscellaneous
After dinner, woman develops sudden-onset9 severe, generalized abdominal pain, and accompanied by deterioration in patient's condition. The abdomen exhibits a board-like rigidity and the patient is disinclined to move because of the pain. The classical presentation is due to A. Acute cholecystitis B. Acute appendicitis C. Perforated peptic ulcer D. Acute pancreatitis
Perforated peptic ulcer
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Streptomycin is a bactericidal antibiotic, the first of a class of drugs called aminoglycosides to be discovered, and was the first antibiotic remedy for tuberculosis. It is derived from the actinobacterium Streptomyces griseus. Streptomycin cannot be given orally, but must be administered by regular intramuscular injections. An adverse effect of this medicine is ototoxicity, it is highly contraindicated in pregnancy because of ototoxicity in fetus. Ref: Richard Finkel, Michelle Alexia Clark, Pamela C. Champe, Luigi X. Cubeddu (2009), Chapter 34, "Antimycrobials", In the book, "Pharmacology", 4th Edition, Lippincott Williams and Wilkins Publications, United States, Page 404 ; KD Tripathi, 5th Edition, Page 681
Pharmacology
null
Which of the following anti-tubercular drug is contraindicated in pregnancy? A. Ethambutol B. Isoniazid C. Rifampicin D. Streptomycin
Streptomycin
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The severe form of Marfan syndrome is caused by a mutation in a single allele of the fibrillin gene (FBN1). The gene product is a major component of elastin-associated microfibrils. Long, thin extremities; ectopia lentis; and aortic aneurysms are the classical triad. Milder forms of the disease probably also occur but are hard to classify. Mutations in the FBN2 gene can also cause Marfan syndrome, but without aneurysms.
Medicine
Endocrinology
A 22-year-old man has features of arm span greater than height, subluxed lenses, flattened corneas, and dilation of the aortic ring. Which of the following is the most likely diagnosis? A. Ehlers-Danlos syndrome B. Marfan syndrome C. Werner's syndrome D. Laurence-Moon-Biedl syndrome
Marfan syndrome
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Bacillus Anthrax causes malignant pustule which later becomes vesicule containing fluid, this is also known as cutaneous Anthrax or Hide poer's disease since it is common in dockworkers containing load of hides and skin on their back surface.
Microbiology
NEET 2019
A person working in an abattoir presented with malignant pustule on hand; What is the causative agent? A. Clostridium botulinum B. ostridium perfringens C. Bacillus anthracis D. Streptococcus pyogenes
Bacillus anthracis
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Veebral levels5th rib, 5th intercostal space, T9 veebra: Right and left dome of diaphragm at max expirationC3 veebra: Hyoid boneC6 veebra: Inferior border of cricoid cailage, division of larynx and tracheaC6 veebra: Inferior cricoid cailage, division of larynx and tracheaC6-T1 veebra: Thyroid glandC7 veebra: Veebra prominensC7 veebra: Superior limit of rhomboid minorveebra: Superior mesenteric aeryLl-L2 veebra: Left crus of diaphragmLl-L3 veebra: Right crus of diaphragmL3 to L4 veebra: UmbilicusL3 veebra: Inferior mesenteric aery and lower border of 10th ribL3 veebra: Right kidney present but not leftL4 veebra: Bifurcation of abdominal aoaL4 veebra: Tubercle of iliac crest and bifurcation of abdominal aoaL4 veebra: Tubercle of iliac crestL5 veebra: Convergence of common iliac veinsS2 veebra: PSISS4 veebra: Natal cleftT1 veebra: Sternoclavicular jointT2 veebra: Superior angle of the scapulaT3 veebra: Base of spine of scapulaT4-T5 interveebral disc: Sternal angleT6-Interveebral disc: Bifurcation of tracheaT5 veebra: Inferior border of rhomboid majorT5-T9 veebra: Sternum properT8 veebra: Caval hiatus of diaphragmT9 veebra: Xiphosternal jointT10 veebra: Esophogeal hiatus of diaphragmT12 veebra: Celiac trunkT12 veebra: Superior border of kidneysT12 veebra: Aoic hiatus of diaphragm
Anatomy
null
Lower limit of left crus of diaphragm is at which veebral level: A. 8th dorsal B. 10th dorsal C. 2nd lumbar D. 3rd lumbar
2nd lumbar
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Radiological features of scurvy: Palkan spur : metaphyseal spurs projecting at right angles to the shaft. White line of Frankel : calcified cailage in the metaphysis Trumefeld zone : zone of rarefraction below the white line of Frankel Wimburger sign : ring surrounding the ephiphyseal centres of ossification Pencil thin coex Subperiosteal hemorrhages Generalised osteoporosis
Radiology
Skeletal system
Wimberger sign is seen in A. Lead poisoning B. Scurvy C. Osteomalacia D. Bone infarct
Scurvy
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Ans. is 'a' i.e., E. coli Pyelonephritis in pregnancyo There is increased chance of urinary tract infection in females as compared to males.o The overall incidence of pyelonephritis in pregnancy is between 1% and 3%.o It is more common in primigravidae than multiparae. Previous history of urinary tract infection increases the chance by 50%. Presence of asymptomatic bacteriuria increases the chance by 25%. Abnormality in the renal tract is found in about 25%.o Physiologic changes responsible for acute pyelonephritis in pregnancy are: (1) low ureteral peristalsis due to high progesterone levels. (2) Dextrorotation of gravid uterus causing compression of right ureter. Pyelonephritis occurs more on the right side (70-80%) compared the left (10-15%).o Predisposing /actors-Dilatation of the ureters and renal pelvis and stasis of the urine in the bladder and ureters are the normal physiological changes during pregnancy.o The organisms responsible are E. coli (70%), Klebsiella pneumoniae (10%), Enterobacter, Proteus, Pseudomonas and Staphylococcus aureus group. About 10% of women develop bacteremia following acute pyelonephritis. 70- 80% of pyelonephritis occur on the right side, 10-15% on the left side and only few are bilateral.
Gynaecology & Obstetrics
Renal and Urinary Tract Disorders
Most common cause of pyelonephritis in pregnancy is - A. E.coli B. Staphylococcus aureus C. Gardnella vaginalis D. B. fragilis
E.coli
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Ans. is 'c' i.e.,HMP shunt HMP shunt does not produce energy.HMP shunt is paicularly impoant for two purposes :-Synthesis of ribose for nucleotide and nucleic acid formation.Formation of NADPH which plays impoant role in several other biological processes, e.g. synthesis of fatty acids, cholesterol, steroid hormones and neurotransmitters.
Biochemistry
null
Least energy producing cycle A. Glycolysis B. Kreb's cycle C. HMP shunt D. Fatty acid oxidation
HMP shunt
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Aschoff bodies are pathognomonic of Rheumatic heart disease.
Pathology
null
Aschoff bodies are seen in A. Arrhythmogenic right ventricular cardiomyopathy B. Kawasaki disease C. Rheumatic heart disease D. Infective endocarditis
Rheumatic heart disease
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Ans. is 'd' i.e. 5-6 mg/kg o Aminophylline is a preparation of theophylline, where theophylline is complexed with EDTA. o The i.v. injection must be slow (loading dose of 5 mg/kg over 20 min followed by an infusion of 9 mg/kg/h, adjusted according to subsequent plasma theophylline concentrations).
Pharmacology
null
The loading dose of Aminophylline is- A. 50-75 mg/kg B. 0.5-1.0 mg/kg C. 2.0-3.5 mg/kg D. 5-6 mg/kg
5-6 mg/kg
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Young females have dense brest tissue,thus sensitivity of mammo is low.
Radiology
null
Sensitivity of mammography is low in young females because A. Young breast have dense tissue B. Young breast have more fat C. has less fat D. less glandular tissue
Young breast have dense tissue
94c6eb6a-be54-40f5-b30f-31bf9d401148
A variety of familial forms of amyloidosis have been described; most are rare and occur in limited geographic areas. The best-characterized is an autosomal recessive condition called familial Mediterranean fever. This is a febrile disorder characterized by attacks of fever accompanied by inflammation of serosal surfaces, including peritoneum, pleura, and synol membrane. This disorder is encountered largely in persons of Armenian, Sephardic Jewish, and Arabic origins. It is associated with widespread tissue involvement indistinguishable from reactive systemic amyloidosis. The amyloid fibril proteins are made up of AA proteins, suggesting that this form of amyloidosis is related to the recurrent bouts of inflammation that characterize this disease. The gene for familial Mediterranean fever is called pyrin and encodes a protein that is a component of the inflammasome (Chapter 2). Patients have gain-of-function mutations in pyrin that result in constitutive overproduction of the proinflammatory cytokine IL-1 and persistent inflammation Robbins 9 th edition page no. 155
Pathology
General pathology
Which of the following is (are) Heredofamilial amyloidosis - A. Alzheimer's disease B. Multiple myeloma C. Familial mediterranean fever D. RA
Familial mediterranean fever
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Ans. is 'b' i.e., Gabapentin Antiepileptics interfering with folic acid metabolism. 1. Phenytoin 2. Phenobarbitone 3. Primidone
Pharmacology
null
Which one of the following drugs does not interfere with folic acid metabolism? A. Phenytoin B. Gabapentin C. Phenobarbitone D. Primidone
Gabapentin
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The stepwise approach to the management of asthma Step 1: Occasional use of inhaled sho-acting b2-adrenoreceptor agonist bronchodilators A variety of different inhaled devices are available and the choice of device should be guided by patient preference and competence its use. The metered-dose inhaler remains the most widely prescribed . For patients with mild intermittent asthma (symptoms less than once a week for 3 months and fewer than two nocturnal episodes per month), it is usually sufficient to prescribe an inhaled sho-acting b2-agonist, such as salbutamol or terbutaline, to be used as required. However, many patients (and their physicians) under-estimate the severity of asthma. A history of a severe exacerbation should lead to a step-up in treatment. (BUD), fluticasone, mometasone or ciclesonide) should be staed in addition to inhaled b2-agonists taken on an as-required basis for any patient who: * has experienced an exacerbation of asthma in the last 2 years * uses inhaled b2-agonists three times a week or more * repos symptoms three times a week or more * is awakened by asthma one night per week. For adults, a reasonable staing dose is 400 ug beclometasone dipropionate (BDP) or equivalent per day in adults, although higher doses may be required in smokers. Alternative but much less effective preventive agents include chromones, leukotriene receptor antagonists and theophyllines. The preferred asthma medications are sho-acting beta-2 agonists such asalbuterol. Taken 10 minutes before exercise, thesemedicationscan prevent the airways from contracting and help control exercise-induced asthma. Having good control of asthma in general will also help prevent exercise-induced symptoms Ref Davidson edition23rd pg 571
Medicine
Respiratory system
Best treatment for exercise induced asthma is A. Montelukast B. Salbutamol C. Ipratopium D. Low dose inhaled steroids
Salbutamol
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Ans. is 'a' i.e., VDRL for mother and Baby Bullous lesion and periostitis suggest the diagnosis of congenital syphilis. o The only option related to syphilis is option 'a'. o Following evaluations are recommended : - 1. Physical examiation 2. A quantitative nontreponemal test for syphilis (VDRL). 3. CSF for cell count, protein & VDRL. 4. Long bone radiograph 5. Antitreponemal IgM.
Pediatrics
null
Premature baby of 34 wks was delivered. Baby developed bullous lesion on the skin and X-ray shows periostitis. What should be the fleet investigation ? A. VDRL for mother & baby B. ELISA for HIV C. PCR for TB D. Hepatitis surface antigen for mother
VDRL for mother & baby
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There is universal agreement on the need for regular Pap smears in young women. There is no need to screen for colon cancer (fecal occult blood) or lung tumors (CXR), particularly at this age. Mammography, if indicated for screening, would be only for older women. Many authorities recommend breast self-examination as well as physical examination by a physician.
Medicine
Oncology
A 25-year-old woman has recently moved to a new city. She comes today for her first routine visit and annual physical assessment. She feels well, reports no new symptoms, and her past medical history is negative. Her only medication is the oral contraceptive pill; she is currently in university and drinks on a social basis. She reports smoking in her teens but quit 7 years ago. The physical examination is completely normal. She asks you about screening tests for cancer at her age. Which of the following cancer screening tests are recommended for her age group? A. mammography every 5 years B. Pap smear at least every 3 years C. stool for occult blood D. chest x-ray (CXR) every 3 years
Pap smear at least every 3 years
d5b40b17-2978-492e-a5ec-067ad06cbf6a
d. Mid arm circumferenceA measuring tape with cm markings (from 6to26cm) with 3 colored zones (red, yellow & green) is a Shakir's tape.
Pediatrics
Growth, Development, and Behavior
What is this instrument used to measure? A. Body mass index B. Skin fold thickness C. Upper segment: lower segment ratio D. Mid arm circumference
Mid arm circumference
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Spectroscopic test is the most specific for blood stains. Tests for blood stains Spectroscopy tests can give information about what chemical compounds and elements are present in a sample, whether ceain types of degradation have occurred in a sample, the amount and type of crystallinity present in the sample, to name a few uses. Ref ganong's review of medical physiology 25e
Physiology
All India exam
Most specific test to detect blood stains is A. Benzidine test B. Teichmann's test C. Ohotoluidine test D. Spectroscopic test
Spectroscopic test
b4b0c583-c221-45bb-ab4e-0906f9cf64a6
Ans. is 'b' i.e., Sodium balance * One of the most important metabolic (non-respiratory) function of lungs is activation of relatively physiologically in active decapeptide angiotensin I to 50 times more potent (active) vasoconstrictor, pressor (|BP), aldosterone stimulating octapeptid angiotensin II by extracellular ACE on the surface of endothelial cells in pulmonary circulation.* Asa part of renin-angiotensin-aldesterone system, lungs indirectly regulate sodium and water balance (and BP). However, lungs also directly affect Na+ balance via epithelial Na+ channels (E NaCs). Absorption of excess fluid from alveolar lumen and airways require active transepithelial transport of Na+ by ENaCs (mainly of alveolar type II and possibly type I cells).
Physiology
Respiratory System
Non-respiratory function of lungs - A. Anion balance B. Sodium balance C. Potassium balance D. Calcium balance
Sodium balance
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Pre renal Renal (ATN) Post renal Urine osmolality > 500 mOsm ~ 300 mOsm <400 mOsm Urine sodium <20 mmol/dl >20 mmol/dl Variable FeNa <1 >1 Variable Urine microscopic findings Hyaline casts Muddy brown casts Normal or RBC/WBC BUN: creatinine ratio >20:1 (normal 10:1) <20:1 >20:1
Medicine
Nephrology
Investigations in a patient of oliguria revealed: Urine osmolality: 800 mOsm/kg. Urinary sodium 10 mmol/L.BUN: creatinine=20:1. What is the most likely diagnosis? A. Pre-renal acute renal failure B. Acute tubular necrosis C. Acute coical necrosis D. Urinary tract obstruction
Pre-renal acute renal failure
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CRIMINAL NEGLIGENCE: The question of criminal negligence may arise: 1) When a doctor shows gross absence of skill or care during treatment resulting in serious injury or death of the patient. 2) When a doctor performs an illegal act. 3) When an assaulant person dies, the defence may attribute the death to the negligence in the treatment of the decreased by the doctor. PROSECUTION: Criminal negligence is more serious than the civil. section 304-A, I.P.C. deals with criminal negligence. Whoever causes the death of any person, by doing any rash or negligent act not amounting to culpable homicide, shall be punished with imprisonment up to 2 years, or with fine or with both. REF: Dr K. S. Narayan Reddys Synopsis of Forensic Medicine & Toxicology 29th edition pg. 23.
Forensic Medicine
Medico legal procedures
Criminal negligence is punishable under section 304 A for a maximum of - A. 1 year B. 2 years C. 3 years D. 5 years
2 years
29326b17-b6fe-4d86-89d7-c48e1214b465
Ans: b (Ethylene glycol)Ref: Harrison, 17 ed. pg. 291, Davidson 21 ed. pg.Ethylene glycol poisoning (Antifreeze)Ethylene glycol is metabolized into glycoaldehyde, glycolic acid, glycoxylic acid, oxalic acid causing metabolic acidosis; oxalate causes renal damage due to calcium oxalate crystals in urine.C/F: Ophthalmpoplegia, cranial nerve palsies, myoclonus, hyporeflexia renal failureManagement* Assay not widely available* Diagnosed by the presence of high anion gap, osmolal gap> 10 mOsm and presence of oxalate crystals in urine* Antidote - Oral ethanol, Fomipazole -Inhibit alcohol dehydrogenase* Hemodialysis in severe cases* Hypocalcaemia treated only if severe ECG changes/ seizures present
Medicine
Kidney
Oxalate crystals in urine is seen in poisoning with A. Methanol B. Ethylene glycol C. Potassium dichromate D. Methylene blue
Ethylene glycol
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Chief cells are more abundant in the fundus of the stomach. Cardiac poion of stomach is rich in mucus secreting glands and have few parietal or chief cells. Body of stomach is rich in parietal and mucous cells and pyloric pa of stomach is rich in enteroendocrine cells. Ref: Modern Nutrition In Health and Disease By Maurice Edward Shils, 10th Edition, Page 1117
Anatomy
null
Chief cells are most abundant in which pa of the stomach? A. Fundus B. Body C. Antrum D. Pylorus
Fundus
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Ans. is `d' i.e., Electrophoresis Bence Jones proteins are seen in multiple myeloma. Urinary protein electrophoresis will exhibit a discrete protein peak. In myeloma plasma cells produce immuno-globulin of a single heavy and light chain, a monoclonal protein commonly referred to as a paraprotein. Heat test is false negative in 50% of patients with light chain myeloma. Dipstick detects albumin and not paraproteins.
Medicine
null
Bence jones proteinuria is best detected by A. Dipstick method B. Sulfosalicylic acid C. Heat test D. Electrophoresis
Electrophoresis
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Huntington disease (HD) Mutation in the HTT gene which codes for protein called huntingtin which is impoant to neurons. The HTT mutation involves a DNA segment known as a CAG trinucleotide repeat. Made up of a series of three DNA building blocks (cytosine, adenine, and guanine) that appear multiple times in a row leading to the disease.
Pathology
Genetics
In Huntington chorea the causative mutation in the protein huntingtin is a: A. Point mutation B. Gene deletion C. Frameshift mutation D. Trinucleotide repeat expansion
Trinucleotide repeat expansion
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Assault: An offer of threat or attempt to apply force to the body of another in a hostile manner (Sec. 351 IPC).1 It does not matter whether it injures him physically or not. Shaking of head or showing of a fist at a person in a hostile manner will constitute an assault. Ref - Krishan Vij textbook of forensic medicine and toxicology 5e pg : 210
Forensic Medicine
Medical Jurisprudence
Person had a fight with a neighour where he assaulted him, he can be booked under A. 44 IPC B. 319 IPC C. 320 IPC D. 351 IPC
351 IPC
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ANSWER: (C) Gray matter of the spinal cordREF: Neurobiology: molecules, cells, and systems By Gary G. Matthew, Page 176-177 "Renshaw cells of grey matter of spinal cord produces self-inhibition of motor neurons.The axons of motor neurons send branches that make excitatory synaptic connection onto Renshaw cells. The Renshaw cells in turn make inhibitory synaptic connections back onto the same motor neuron"
Physiology
Nerve Physiology
Renshaw cells are inhibitory interneurons found in? A. Gray matter of brain B. White matter of brain C. Gray matter of the spinal cord D. White matter of spinal cord
Gray matter of the spinal cord
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Flocculonodular lobe has direct connections with vestibular nuclei and it is concerned with balance, equilibrium and eyeball movements Ref: Ganong 25th ed/page 248
Physiology
Nervous system
Flocculonodular lobe has direct connections with A. Red nucleus B. Inferior olivary nucleus C. Vestibular nucleus D. Dentate nucleus
Vestibular nucleus
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Ans. is 'b' i.e., 16, 18 o HPV type 6 & 11 are known to be associated with warts.o HPV type 16, 18, 31 & 33 are associated with cervical carcinoma & CIN. Out of wrhich 16 & 18 are most oncogenic.
Gynaecology & Obstetrics
Aetiological factors
Cervical carcinoma is due to HPV - A. 6,8 B. 16,18 C. 30, 32 D. 15, 17
16,18
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Ans. c. Redistribution of the drug from sites in the CNSAn IV anesthetic completely bypasses the process of absorption, because the drug is placed directly into the bloodstream. Highly perfused organs (vessel rich) including the brain take up disproportionately large amount of drug compared to less perfused areas (the muscle, fat, and vessel-poor groups).Drugs bound to plasma proteins are unavailable for uptake by an organ.After the highly perfused organs are saturated during initial distribution, the greater mass of the less perfused organs continue to take up drug from the bloodstream.As plasma concentration falls, some drug leaves the highly perfused organs to maintain equilibrium.This redistribution from the vessel-rich group is responsible for termination of effect of many anesthetic drugs.
Anaesthesia
General Anesthesia
Which of the following determines the speed of recovery from IV anesthetic? A. Liver metabolism of drug B. Protein binding of drug C. Redistribution of the drug from sites in the CNS D. Plasma clearance of the drug
Redistribution of the drug from sites in the CNS
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Hb-O2 dissociation curve shift to left indicates more affinity of Hb to O2 and thus less delivery of O2 to tissues. Hb-O2 dissociation curve shift to right indicates less affinity of Hb to O2, and thus more delivery of O2 to tissues. When P50 increases, the affinity of Hb to O2 decreases, or there is a shift of the curve to the right. Among the given options, the only decrease in pH causes a right shift of the curve. All others when decreased cause shifts to left.
Physiology
null
Increase in P50 results in change in oxygenation curve, which is due to decrease in A. pH B. Oxygen C. Temperature D. CO2
pH
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Platelets are stored at 20 – 24 degree Celsius with agitation. They can only be stored for 5 days. Whole blood and packed red cells are stored at 2 – 6 degree Celsius for 35 days. The anticoagulants which are used for their storage are either CPD (Citrate, Phosphate, Dextrose) or CPDA (Citrate, Phosphate, Dextrose, Adenine). Fresh frozen plasma is stored at –18 degree Celsius for 1 year.
Pathology
null
Platelets are stored at A. 5°C for 1 month B. 20-24°C for 5 days C. -4°C for 3 months D. 20-24°C for 3 days
20-24°C for 5 days
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Refer above table Treatment of operable NSCCL Stage IA, IB, IIA, IIB : Surgical resection Adjuvant chemotherapy is given in stage II Stage IIIA with minimal N2 involvement : Neoadjuvant chemotherapy followed by surgical resection with complete Mediastinal LN dissection Postoperative radiotherapy for patients found to have N2 disease Ref : Sabiston 20th edition Pgno : 1591
Surgery
Urology
A 60 year old male was diagnosed as carcinoma right lung. On CECT chest there was tumour of 5 x 5 cm in upper lobe and another 2 x 2 cm size tumour nodule in middle lobe. The primary modality of treatment is A. Radiotherapy B. Chemotherapy C. Surgery D. Suppoive treatment
Surgery
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Ans. (a) Pemphigus vulgarisHarrison 19th ed. / 370* The rounded keratinocytes with hyperchromatic nuclei and perinuclear halo (due to condensing of cytoplasm in periphery) are called acantholytic cells.* It is seen in case of pemphigus vulgaris* Acantholytic cells can be demonstrated in bed side Tzanck test.
Skin
General
Acantholytic cells are seen in A. Pemphigus vulgaris B. Bullous pemphigoid C. Cicatricial pemphigoid D. Dermatitis herpetiformis
Pemphigus vulgaris
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The impoance of protection afforded by acute inflammatory cells is emphasized by the frequency and severity of infections in persons with defective phagocytic cells. The most common defect is iatrogenic neutropenia secondary to cancer chemotherapy. Chemotherapy would not be expected to deplete serum levels of complement or alter the respiratory burst within activated neutrophils .
Pathology
Basic Concepts and Vascular changes of Acute Inflammation
A 50-year-old woman is discovered to have metastatic breast cancer. One week after receiving her first dose of chemotherapy, she develops bacterial pneumonia. Which of the following best explains this patient's susceptibility to bacterial infection? A. Depletion of serum complement B. Impaired neutrophil respiratory burst C. Inhibition of clotting factor activation D. Neutropenia
Neutropenia
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Streptococcal and Actinomyces species are initial colonizers of dental plaque. They are grampositive, facultative micro-organisms.
Dental
null
What are the characteristics of the primary (initial) bacterial colonizers of the tooth in dental plaque formation? A. Gram-negative facultative B. Gram-positive facultative C. Gram-negative anaerobic D. Gram-positive anaerobic
Gram-positive facultative
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Ans is 'b' i.e. Compulsive eating of hair o Trichophagia is compulsive eating of hair and is usually associated with trichotillomania i.e. compulsive pulling of hair.o Compulsive shopping is called Oniomania.o Compulsive stealing is called Kleptomania.Also knowo Pyromania i.e. pathological fire setting
Psychiatry
Mood Disorders
Trichophagia is characterized by - A. Compulsive pulling of hair B. Compulsive eating of hair C. Compulsive shopping D. Compulsive stealing
Compulsive eating of hair
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D i.e. Depressive disorder: - Repetitive transcranial magnetic stimulation (rTMS) is USFDA approved for treatment of resistant depressionQ and has been shown to have efficacy. Vagus nerve stimulation (VNS) has also recently been approved for treatment of resistant depressionQ, but its degree of efficacy is controversial. Deep brain stimulation (DBS) is being used experimentally in treatment resistant cases. - ECT is at least as effective as medication, but its ue is reserved for treatment of resistant cases and delusional depressionQ.
Psychiatry
null
Repetitive transcranial magnetic stimulation (rTMS) which is approved by USFDA for the treatment of: A. Resistant schizophrenia B. Obsessive compulsive disorder C. Acute psychosis D. Depressive disorder
Depressive disorder
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Maternal moality ratio is the number of maternal deaths per 1,00,000 live bihs. This is a ratio and not a rate because the numerator may include cases which are not included in the denominator. This ratio reflects the level of obstetric risk associated with pregnancy TEXTBOOK OF OBSTETRICS.,SHEILA BALAKRISHNAN,pg no:594,2nd edition
Gynaecology & Obstetrics
Medical, surgical and gynaecological illness complicating pregnancy
MMR is expressed in : A. Per 1000 live bih B. Per 10000 live bih C. Per 1 lakh live bih D. Per 10 lakh live bih
Per 1 lakh live bih
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Ans. B i.e. Thelarche Thelarche is the onset of secondary (postnatal) breast development, usually occurring at the beginning of pubey in girls.
Gynaecology & Obstetrics
null
Appearance of Breast bud is known as: March 2013 A. Menarche B. Thelarche C. Pubarche D. Anarche
Thelarche
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Uterine inversion presents after excessive traction on cord for pulling out the placenta, which leads to paial or complete inversion of uterus. It is usually associated with PPH and may result in shock (hemorrhagic and neurogenic. However more common cause of moality is hemorrhagic) if treatment is delayed.
Gynaecology & Obstetrics
Labour - III
A patient presents in emergency in shock, with a history off fleshy mass protruding from vagina with heavy bleeding PV. She had history of delivery at home 1 hour back by a health worker with a history of difficulty in placental removal and 'Uterine handling'. Most probable diagnosis is? A. Atonic PPH B. Uterine inversion C. Fibroid polyp D. Cervical tear
Uterine inversion
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Plasma volume = Total blood volume * (1 - Hematocrit) The total blood volume is about 8% of body weight Blood volume of 60 kg man = 0.08 * 60 = 4.8 L Plasma volume = total blood volume * (1-hematocrit) = 4.8 * (1-0.40) = 4.8 * 0.60 = 2.88 L Also, about 60% of the blood is plasma and 40% is RBCs Thus, plasma = 5% of body weight and haematocrit is 3% of body weight
Physiology
Body fluid compaments
A 60 kg man has haematocrit of 40%. His plasma volume would be approximately: A. 2.4 L B. 2.9 L C. 3.6 L D. 5.0 L
2.9 L
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C. (post strep. GN). This patient is suffering from post-streptococcal glomerulonephritis (C), which forms pa of the nephritic syndrome consisting of haematuria (micro- or macroscopic), hypeension, proteinuria and oedema. In severe cases, oliguria and uraemia can also occur. Patients usually suffer form a streptococcal infection 1-3 weeks prior to presenting with the above symptoms or signs of the nephritic syndrome. During this time, immune complexes are formed and deposited in the glomeruli causing damage. The nephrotic syndrome (A) involves albuminuria usually in the order of 3.5 g/d in adults causing oedema and is also associated with hyperlipidaemia (increased LDL/HDL ratio). Nephritic syndrome (B) involves haematuria (micro- or macroscopic) alongside hypeension and proteinuria. A Von Grawitz tumour (option D), otherwise known as renal cell cancer, typically occur in males (2:1 male to female ratio) originating from the proximal tabular epithelium. The average age of presentation is 50 years with symptoms including pain, haematuria and usually a mass in the flank alongside other symptoms of malignancy such as weight loss.
Surgery
null
A 17-year-old patient is referred by his GP after presenting with periorbital oedema. The patient noticed the oedematous eyes 3 days ago, but repos feeling unwell since a throat infection 3 weeks ago with nausea and vomiting in the last week. A urine dipstick is positive for protein and blood while serum creatinine and urea are mildly deranged. The most likely diagnosis is: A. Nephrotic syndrome B. Nephritic syndrome C. Post streptococcal GN D. Von Grawitz tumour
Post streptococcal GN
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The descending colon is a retroperitoneal organ. The rest of the organs are surrounded by peritoneum. Other retroperitoneal organs are: - Pancreas, Duodenum, Ascending colon, Descending colon, Middle third of the rectum
Anatomy
Abdominal wall ,Inguinal and Femoral region
A 45 year old male presents to OPD with acute abdominal pain. On examination it seems to have spread to retroperitoneal structure. Which of the following is most likely to get affected A. Stomach B. Transverse colon C. Jejunum D. Descending colon
Descending colon
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. biochemical test gives the same reading of early sample on reputed testing, it is inferred that the measurement is-precise. ref:park&;s textbook ,22 nd edition,pg no 22
Social & Preventive Medicine
Screening
If biochemical test gives the same reading of early sample on reputed testing, it is inferred that the measurement is- A. Precise B. Accurate C. Specific D. Sensitive
Precise
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All NSAIDs, including selective COX-2 inhibitors, are antipyretic, analgesic, and anti-inflammatory, with the exception of acetaminophen, which is antipyretic and analgesic but is largely devoid of anti-inflammatory activity. Ref: Grosser T., Smyth E. (2011). Chapter 34. Anti-inflammatory, Antipyretic, and Analgesic Agents; Pharmacotherapy of Gout. In L.L. Brunton, B.A. Chabner, B.C. Knollmann (Eds), Goodman & Gilman's The Pharmacological Basis of Therapeutics, 12e.
Pharmacology
null
Which of the following NSAID does not having antiinflammatory activity? A. Ketorolac B. Diclofenac C. Mefenamic acid D. Acetaminophen
Acetaminophen
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Ans. is A D-cell (Ref Ganong, 20/e, p. 339). Delta cells secrete - somatostatin* Beta cells secrete - insulin* Alpha cells of pancreas - glucagon*
Medicine
Miscellaneous (Endocrinology)
Somatostatin is secreted by : A. D-cell B. A-cell C. B-cell D. Dl-cell
D-cell
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Because reduced Hb is purple, a low aerial O2 saturation causes cyanosis. However, this is not a reliable sign of mild desaturation because its recognition depends on so many variables, such as lighting conditions and skin pigmentation. Because it is the amount of reduced Hb that is impoant, cyanosis is often marked when polycythemia is present but is difficult to detect in anemic patients.
Physiology
Respiratory system
Cyanosis does not occur in severe anemia because A. Hypoxia stimulates erythropoietin secretion B. Oxygen carrying capacity of available Hb is increased C. Critical concentration of Hb required to produce cyanosis is reduced D. Oxygen Dissociation Curve shifts to right
Critical concentration of Hb required to produce cyanosis is reduced