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We report the occurrence of renal failure due to cholesterol crystal embolization following thrombolytic therapy with intravenous recombinant tissue-type plasminogen activator (t-PA).
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He had experienced only 2 mild peritonitis attacks with fever within 1 year.
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Treatment with local antibiotics was initiated but the condition of the eye worsened, ultimately resulting in corneal perforation.
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One patient was treated with disothiazide for premenstrual edema.
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Deepening of lid sulcus from topical bimatoprost therapy.
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Serologic responses were highly suggestive of T. gondii as the etiology in all cases; other causes (CMV retinitis and syphilis) were actively sought and were not found.
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The beta-oxidation pathway of VPA was shown to be suppressed (lack of 3-keto-VPA), whereas metabolites from the omega-oxidation pathway could still be measured (urinary 5-OH-VPA plus 2-propylglutaric acid ca. 1.6%, controls more than 10%).
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One previous study of four transplant patients whose immediate post-transplantation immunosuppression utilized corticosteroids, cyclosporine, MMF, and anti-T-lymphocyte globulin noted anemia in 13% of them.
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Fine-needle aspiration cytology in locally advanced breast adenocarcinoma: a case with complete response to preoperative chemotherapy in association with granulomatous inflammatory reaction.
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A specific autoimmune disease was not identified.
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In court, the female offender confessed and was sentenced to prison for 3 1/2 years.
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This case demonstrates an occupational activity (construction) that has now become the dominant source of lead exposure for U.S. adults, the importance of a good occupational history to suspecting and making a diagnosis, the possible outcomes of chronic lead toxicity, and the importance of preventing further exposure and using proper methods to treat acute toxicity.
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A 34-year-old man presented 4 months after renal transplantation with a 1-week history of epigastric pain that decreased in supine position, increased while sitting, and further increased when standing or walking.
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A 65-year-old man with advanced prostate cancer was treated with a luteinizing hormone-releasing hormone (LH-RH) analogue.
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Squamous cell carcinoma in vitiligo lesion after long-term PUVA therapy.
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On the second day of hospitalization, it was noted that the patient's dyspnea and sinus bradycardia could be related to a recent increase in his timolol dosage.
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This study presents the case of rapidly progressing pulmonary aspergillosis in a 47-year-old woman who had healed cavitations of pulmonary tuberculosis in the right upper lobe.
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The drug, widely used in gastroenterological and gynaecological practice, has not hitherto been considered neurotoxic.
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CASE SUMMARY: A 65-year-old patient chronically treated with the selective serotonin reuptake inhibitor (SSRI) citalopram developed confusion, agitation, tachycardia, tremors, myoclonic jerks and unsteady gait, consistent with serotonin syndrome, following initiation of fentanyl, and all symptoms and signs resolved following discontinuation of fentanyl.
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Postoperative imaging did not disclose any intra-orbital abnormalities.
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CASE SUMMARY: A 45-year-old HIV-positive man (CD4+ count 450 cells/mm(3) and history of AIDS-defining illness) presented with JHR after an initial intravenous dose of penicillin G for presumed neurosyphilis.
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OBSERVATIONS: A 48-year-old woman presented with disfiguring facial edema 10 weeks after she began antiviral therapy with peginterferon alfa-2a and ribavirin for chronic hepatitis C infection.
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It has been recently approved for the treatment of multiple myeloma, an incurable plasma cell tumour that accounts for 10-15% of all haematologic malignancies and for approximately 20% of deaths.
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We report the successful treatment of heparin-induced thrombocytopenia and subsequent hemorrhagic complications postoperatively in a 2-year-old child with Danaparoid (orgaran).
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A patient is described with the characteristic features of phenytoin hypersensitivity syndrome (PHS) including fever, erythroderma, tibial and facial oedema, pinhead-sized facial pustules and abnormal liver function tests.
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Multiple myeloma complicated by congestive heart failure following first administration of recombinant alpha-interferon.
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Neuroleptic malignant syndrome (NMS) is a potentially life-threatening adverse effect of antipsychotic agents.
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A study protocol to manage these patients within a multidisciplinary team including also specialists in infectious diseases and virologists is mandatory.
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She had no other causes of immunosuppression.
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By X-ray fluorescent spectroscopic examination, gold was seen to be present within the proximal convoluted tubular cells but was not identified in the glomerular subepithelial deposits.
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All-trans retinoic acid-induced focal myositis, synovitis, and mononeuritis.
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Methylphenidate and dextroamphetamine-induced peripheral vasculopathy.
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Prolonged exposure to ART, specially ddl, can play a pathogenic role.
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Pulmonary infiltrates and skin pigmentation associated with sulfasalazine.
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Nitrofurantoin therapy was discontinued.
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We hypothesize that capecitabine-induced headache is vascular in nature.
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Desmopressin is a commonly used, well-tolerated agent for the treatment of primary nocturnal enuresis and central diabetes insipidus.
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The combination of sulfadiazine and pyrimethamine is regarded as the treatment of choice.
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The progress and management of this complication are described in the patient is being reported.
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Lamivudine is the most widely prescribed drug of choice for chronic hepatitis B infection, which is a common health problem in China.
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RESULTS: The population consisted of 11 female and 2 male patients with RA.
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Further studies are needed to confirm this association and to determine whether inhaled adrenergic agents also contribute to the development of this disorder.
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The psychotic behavior resolved completely soon after the discontinuation of levetiracetam.
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The episode appeared to have been precipitated by toxicity due to ingestion of a large amount of phenytoin.
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Severe acidosis from acetazolamide in a diabetic patient.
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Seventy-four per cent of patients with epileptogenic disorders seen at the Emergency Unit at Groote Schuur Hospital were on phenytoin and 11.6% of these had blood levels in the toxic range.
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Laser in situ keratomileusis (LASIK) carries the risk of infection.
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All parameters returned to normal after the herbal preparation was discontinued.
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Cyproterone acetate (CPA) is a steroidal synthetic progestagen and anti-androgenic compound widely administered in prostate cancer which has been evidentially correlated with a severe hepatotoxic potency.
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We report the case of a 14-year-old female with acute promyelocytic leukemia who developed symptomatic cardiomyopathy only 4 months into treatment with a combination of daunomycin and all-trans retinoic acid (ATRA).
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Our findings suggest that hyperkalemia can develop with the use of low-dose heparin, within seven days of initiating heparin therapy, and that patients with diabetes mellitus or chronic renal insufficiency are especially predisposed to this complication.
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Here we describe a patient with Crohn's disease who developed a severe infliximab infusion reaction (IIR), complicated 1 day later by severe swelling of the forearm and hand ipsilateral to the site of infliximab infusion.
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These results suggested that the visual dysfunction might be entirely attributable to retinal rather than optic nerve toxicity.
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There are no previous reports in the literature about the emergence of CML during treatment with hydroxyurea.
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They provided conflicting testimony as to alleged violations of the standard of care.
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OBJECTIVE: The aim of this study was to introduce a useful diagnostic method to evaluate baclofen pump system-related complications without disturbing the continuous delivery of intrathecal baclofen.
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A 4-year-old boy presented with fever, septic arthritis, and persistent neutropenia.
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The most likely cause of liver failure in this patient was, therefore, clarithromycin, which undergoes hepatic metabolism and has been reported to cause fulminant hepatic failure.
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Rapamycin/sirolimus (SR), trade named Rapammune (Wyeth-Ayerst, Sydney, Australia), is a potent immunosuppressive drug associated with myelosuppression, hypertension, hyperlipidemia, and infection.
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The granulomatous hepatitis occurred in the apparent absence of mycobacteria from the liver.
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Methadone withdrawal when starting an antiretroviral regimen including nevirapine.
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Cisapride enhances detrusor contractility and improves micturition in a woman with lazy bladder.
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A 51-year old physically fit woman experienced angio-oedema and hypotensive shock after irbesartan ingestion requiring noradrenaline infusion.
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Soon after introduction of insulin therapy, she developed severe anasarca, including marked peripheral oedema, ascites and pleural effusion.
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The patients typically exhibit a brief preleukemic phase and poor survival with death occurring 3 to 5 months after diagnosis of leukemia.
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RESULTS: Amino acid PET, performed when the lesions were still small, showed multiple small areas of mild uptake in close correlation to the MRI lesions.
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So this potential drug-drug interaction could be investigated, the patient stopped taking both drugs for 1 week.
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Pharmacokinetic modeling suggested that the patient's initial over-treatment was as reported and that the predicted maximum serum concentration of chloroquine (902 micro g/L) was within the range seen in fatal chloroquine overdose.
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In the present paper, we discuss the first Japanese vivax malaria patient whose QT interval was prolonged after treatment with halofantrine.
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Additive pulmonary toxicity with melphalan and busulfan therapy.
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Nevertheless, osteonecrosis of the jaw (ONJ) has been reported in some patients being treated with bisphosphonates.
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GH insufficiency has not been recognised as a classical manifestation of this syndrome.
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Wolff Parkinson White (WPW) syndrome: what the critical care nurse needs to consider when administering antiarrhythmics.
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PURPOSE: The case of a patient who developed aseptic meningitis, hemolytic anemia, hepatitis, and orthostatic hypotension simultaneously during treatment with trimethoprim-sulfamethoxazole is described.
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Clinical aspects and electrophysiological data such as polygraphic studies, electroencephalography, and measurement of somatosensory evoked potentials support the cortical origin of negative myoclonus.
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We report 3 cases of children with acute lymphoblastic leukemia who developed seizures and altered sensorium after L-asparaginase therapy.
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Rituximab-CHOP induced interstitial pneumonitis in patients with disseminated extranodal marginal zone B cell lymphoma.
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A case of pyridoxine-dependent seizures is reported.
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Close monitoring for QT prolongation or rhythm disturbances is mandatory.
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Symptoms develop during the first 3 months after transplantation and usually disappear 3 to 6 months later without sequelae.
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Conversely, similarities between patient reports and reports from healthcare professionals were found in age, sex, most frequently reported ADRs and most frequently reported drugs.
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CASE: A 48-year-old male patient with a history of tuberculosis and visual loss during anti-tuberculous drug therapy was admitted to our hospital.
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The authors report two cases of delayed elimination of methotrexate in patients receiving ciprofloxacin, with severe toxicity.
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Gestational diabetes was no less severe (degree of hyperglycaemia, need for insulin therapy) when associated with norethisterone.
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Little is known about the prevalence of genotypes and implications for screening in children.
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On subsequent follow-up one patient is taking no insulin and has been maintained on hydrochlorothiazide; the other patient required insulin on two occasions when challenged with a propranolol-thiazide combination, but not when the thiazide was discontinued or replaced with furosemide.
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The interval between initiating treatment with interferon alfa and onset of anterior ischemic optic neuropathy was similar to that of interferon-associated vascular retinopathy.
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A kidney biopsy revealed that he had focal segmental glomerulosclerosis.
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All the patients presented with severe retrosternal pain worsened by swallowing food and drink, and in every case fibre-optic endoscopy revealed ulceration of the midoesophagus.
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We studied a series of patients to determine the onset, visual significance, treatment, and recurrent nature of these pigmented membranes in patients who underwent surgery with silicone lens implantation.
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Those reporting SCs significantly more often reported weight gain than those reporting TSCs, with oral problems and appetite loss significantly less common in the SC group.
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We describe two cases of PSVT that changed to non-sustained polymorphic ventricular tachycardia after administration of verapamil.
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The patient denied taking other drugs.
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Telescoped digits of the hands and feet developed in a 69-year-old male with severe chronic tophaceous gout during allopurinol treatment.
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In 2 cats, rebound hyperglycemia was diagnosed on routine serial blood glucose determinations.
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We report a 5-year-old boy with CF who had a stricture of the hepatic flexure region with associated narrowing due to submucosal fibrosis of the transverse colon, secondary to high-lipase pancreatin therapy.
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First, a review of the literature produced 41 anecdotic cases of neutropenia or agranulocytosis during treatment with olanzapine (Zyprexa) reported in a total of 24 publications.
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Prompt recognition of this syndrome and temporary cessation of CyA therapy may favorable affect the course.
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Cure followed therapy with antibiotic administration for 3 days combined with oral thiabendazole, suggesting parasitic infection as the most likely cause of meningitis.
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Outside the initial associated URTI and LRTI, no further viral pneumonia occurred.
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