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After discontinuation of the 5-fluorocytosine and amphotericin B and treatment with cephradine and ketoconazole, the toxic epidermal necrolysis resolved.
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The anemia continued because of bloody stool caused by Crohn's disease.
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Minocycline-induced autoimmune hepatitis is usually identical to sporadic autoimmune hepatitis.
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Common adverse events (frequency 10%) of lacosamide doses up to 600 mg/day include nonspecific central nervous system effects (e.g., dizziness, ataxia, diplopia, and somnolence).
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Fatal stroke in migraine: a case report with autopsy findings.
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Gold nephropathy: tissue analysis by X-ray fluorescent spectroscopy.
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It can cause severe CNS depression, especially in very young children.
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High plasma levels of N-desmethyl-clobazam (N-CLB), the major metabolite of CLB were detected.
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On the basis of the encouraging results of the initial series, this technique should be considered as an interesting therapeutic alternative in sciatica.
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We describe a case of ulcerative proctitis after ibuprofen treatment in a girl with juvenile systemic lupus erythematosus.
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A 27-year-old man who had a history of bronchial asthma, eosinophilic enteritis, and eosinophilic pneumonia presented with fever, skin eruptions, cervical lymphadenopathy, hepatosplenomegaly, atypical lymphocytosis, and eosinophilia two weeks after receiving trimethoprim (TMP)-sulfamethoxazole (SMX) treatment.
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Their decreases in VAS scores were 86.5%, 85.7%, and 77.6%.
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Treatment with oral contraceptive (OC) for endometriosis and later with cyclophosphamide, methotrexate, fluorouracil (CMF) for breast cancer produced a higher number of attacks.
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This case emphasizes the importance of the evaluation of lithium-associated polyuria with a direct measurement of plasma vasopressin, interpreted with simultaneous plasma and urine osmolality to secure the correct diagnosis and ensure appropriate therapeutic management.
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From 2947 admissions with systemic lupus erythematosus 25 (0.85%) were diagnosed as having acute pancreatitis; 76% of cases had active systemic lupus erythematosus on presentation, with an average of 4.4 organ involvement, and a clustering of renal disease (56%), pleural effusion (48%) and arthritis (44%) in these patients.
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There is a paucity of literature etiologically inculpating other ephedra alkaloids in the causation of intracerebral hemorrhage.
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DESIGN: Description of the clinical findings in two patients with this condition.
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In a patient with severe renovascular hypertension, nonoliguric acute renal failure developed after she received captopril treatment.
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Mannitol-induced ARF responds promptly to hemodialysis with rapid resolution of anuria and recovery of renal failure.
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Local findings included swelling (94%), fang marks (93%), ecchymosis (53%), erythema (37%), bullae (13%), and tissue necrosis (8%).
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She died within six weeks of developing congestive heart failure coupled with liver failure due to haemosiderosis despite regular use of desferrioxamine.
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Surgical re-siting of the intrathecal catheter produced good pain relief for many months.
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Ciprofloxacin-induced psychosis.
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PURPOSE: To report a case of Acanthamoeba infection following LASIK.
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CONCLUSIONS: Patients with PDPH have classic postural headache.
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RESULTS: The inflammatory mass was excised successfully, and several specimens were examined for bacteriologic presence.
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Temozolomide was restarted 2 months later; the patient again developed a fever.
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A patient with low-grade patch stage MF progressively developed MF plaques restricted to his arms, and a tumour on his right thigh.
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Conspicuous endoscopic appearance of ventriculitis caused by coagulase-negative staphylococci.
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The day after clozapine was stopped, while he was still receiving clomipramine 150 mg/d, he began behaving oddly, started sweating profusely, shivering, and became tremulous, agitated, and confused.
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Etoposide-related myocardial infarction.
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CONCLUSION: The new quinolone derivatives (levofloxacin, sparfloxacin, grepafloxacin, trovafloxacin, gatifloxacin and moxifloxacin), also called gyrase inhibitors, are known for their potential to cause central nervous system-related adverse effects, including headache, dizziness and insomnia.
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With continued clearing of consciousness, the patient was successfully discharged.
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Recently, nonsteroidal anti-inflammatory drugs have been used to halt the growth of these tumors, presumably by interfering with prostaglandin metabolism.
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Three patients, in whom tumour overkill by cytotoxic treatment, including high dose methotrexate with folinic acid rescue, resulted in the 'phosphate shower syndrome' (hyper-uricaemia, hyperkalaemia and hyperphosphataemia with hypocalcaemia and tetany, with metabolic acidosis and acute renal impairment) are described.
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Many aspects of this syndrome suggest close similarities between DIHS/DRESS and graft-versus-host disease.
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Diagnostic procedures aimed to explain lower leg edema are not uncommon in the age group of women suffering from climacteric and menopausal symptoms.
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Although the drug is relatively safe, a growing body of literature has noted movement disorders after its administration.
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The authors describe a case of combined lithium and haloperidol toxicity characterized by hyperpyrexia, severe rigidity, mutism, and development of irreversible tardive dyskinesia.
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Controversy as to what constitutes a safe and effective dose of these medications still exists.
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Recombinant human erythropoietin in patients with myelodysplastic syndrome and myelofibrosis.
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Mechanism of topiramate-induced acute-onset myopia and angle closure glaucoma.
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After substitution of a standard diet starting August 21, we found significant decreases of total cholesterol from 725 mg/dl to 194 mg/dl and triglyceride from 4680 mg/dl to 550 mg/dl within 37 days.
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CONCLUSION: The delayed treatment of lead poisoning may lead to irreversible motor neuron defect.
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The electrocardiogram showed alternation of long and short P-P intervals and occasional pauses.
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During clarithromycin coadministration, four out of the seven patients developed moderate-to-severe toxic symptoms of carbamazepine, such as drowsiness, dizziness, and ataxia, which resolved within 5 days after clarithromycin discontinuation.
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Given the evolving role of second autologous transplantations in the therapeutic armamentarium for multiple myeloma, consideration of this potential toxicity may be appropriate when considering treatment options for these patients.
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Patients receiving neutral protamine Hagedorn (NPH) insulin are at increased risk for the development of protamine hypersensitivity.
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Long-term clinical experience with many of these agents has revealed nonglycemic effects on lipid levels, inflammation, and cardiovascular function.
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Bronchospasm is an anesthetic emergency that can lead to disastrous outcomes if treatment is irresolvable.
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OBJECTIVE: Tumor necrosis factor-alpha (TNF-alpha) inhibitors have emerged as a potent treatment for rheumatoid arthritis (RA), but not without significant risks.
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Blood cultures were positive for Agrobacterium yellow group.
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To our knowledge, the syndrome of fever, pulmonary infiltrates, and pleural effusion following use of acyclovir has not been previously reported.
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Specifically, the complication of enzyme-induced hyperglycemia may be seen more frequently after exposure to the E. coli product.
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We describe a drug-drug interaction between itraconazole and efavirenz in a patient with disseminated histoplasmosis and acquired immunodeficiency syndrome (AIDS).
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Objective responses were observed in both basal cell carcinoma (BCC) patients.
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Danaparoid was withheld during this time.
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Cutaneous mycobacterial infection post intravesical BCG installation.
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A 28-year-old man underwent pterygium excision with a single intraoperative application of mitomycin C (0.02%) for 3 minutes.
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We report a 66 year-old man with well-documented, idiopathic generalized epilepsy who developed petit mal status lasting 6 weeks.
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We conclude that the presence of this metabolic defect combined with topical 5-FU (a drug demonstrating a narrow therapeutic index) results in the unusual presentation of life-threatening toxicity after treatment with a topical drug.
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The pulmonary emboli were thought to be associated with her oral contraceptive, which was discontinued at hospital admission.
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It mandates emergency open heart surgery if hemostasis is not achieved promptly.
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Ophthalmologists should undertake the above treatment in consultation with a pediatric endocrinologist.
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Suicidal digoxin poisoning: conventional treatment and antibody therapy.
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Three patients received prophylaxis with MB at a dose of 4 x 50 mg day(-1) i.v. for the subsequent chemotherapy cycles.
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This case report stresses the need for control of the rheumatic condition prior to the initiation of antineoplastic therapy.
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Metronidazole neuropathy.
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We discuss a patient who developed severe renal tubular dysfunction secondary to short-term therapy with Amikacin, resulting in refractory hypokalemia, hypocalcemia, hypomagnesemia, metabolic alkalosis, and polyuria.
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The reactive process included an infiltrative superficial dermatitis and a mural folliculitis with prevalent participation of macrophages and lymphocytes.
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Five patients are described in whom only gentamicin sulfate appeared responsible for acute renal failure.
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Clinical spectrum, ancient mutations, and a survey of 100 American referrals to the National Institutes of Health.
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These patients developed a debilitating photosensitivity that persisted for months to years even after they stopped taking the diuretic.
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Because most infections are late complications and have indolent onsets, a high level of clinical suspicion is required for early diagnosis.
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Controversy concerning the nephrotoxicity of lithium is discussed, and recommendations for the evaluation of renal failure during lithium therapy are provided.
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The patient's initial serum calcium concentration was 5.25 mmol/L (21 mg/dL).
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We report the case of a 17 years old female with a Ewing's sarcoma of the left femur treated with limb sparing surgery followed by local radiotherapy of 45 Gy and adjuvant chemotherapy with vincristine, doxorubicine, cyclophosphamide, actinomycin D.
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However, increased dyspnoea and bronchospasm necessitated reintubation.
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Two additional patients with midly abnormal responses to glucose tolerance tests showed no evidence of altered glucose metabolism when treated with halcinonide cream in a similar manner.
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In this article lithium is not discussed, although there are a number of concerns about lithium's potential teratogenicity, and it has been implicated in Epstein's anomaly, a congenital heart defect among infants born to women taking lithium; as with other medications, however, the data have specific limitations.
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CONCLUSIONS: Physicians should be aware that drug-induced AIN can be associated with proton-pump inhibitors.
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Beneficial effects of telmisartan in an HIV+ diabetic insulin-dependent patient.
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This patient had previously been sensitized to protamine during cardiac catheterization and had high levels of protamine-specific immunoglobulin E in the serum.
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Although inhibition of the angiotensin-converting enzyme is considered to be efficient treatment for hypertension associated with chronic renal failure, care should be taken when captopril is administered initially to a patient with decreased renal function, under the conditions of sodium and water depletion.
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The use of electroconvulsive therapy (ECT) in MG raises certain challenges.
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Interstitial lung disease (ILD) related to therapy with the drug gefitinib has been well reported.
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This is the first report of pulmonary hypertension in an adult patient during lithium therapy.
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A prospective study is currently underway to determine if a clinically measurable adverse effect on retinal function is seen with greater frequency.
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These symptoms were unresponsive to conventional analgesic and antibiotic treatments.
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Painful neutrophilic skin lesions were observed in two children receiving granulocyte colony-stimulating factor (G-CSF) for treatment of idiopathic neutropenia.
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A 32-year-old woman experienced ischemic stroke attributed to concomitant administration of a cough and cold preparation containing methylephedrine and a supplement containing Chinese herbal drugs.
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We describe a patient with a liver abscess due to Entamoeba histolytica, in whom metronidazole therapy (total dose, 21 g over 14 days) was complicated by reversible deafness, tinnitus, and ataxia and who relapsed 5 months later with a splenic abscess.
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We recommend following daily cell counts and vancomycin peak and trough levels to calculate the amount and frequency of intraventricular vancomycin required to maintain safe and effective concentrations and to monitor for CSFE.
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A previously asymptomatic 62-year-old man with a history of hypertension and stable coronary artery disease developed paresthesias and fascicular and ventricular tachycardia after ingestion of an Ayurveda bowel regimen containing substrates from the Aconitum species, which is a known neurotoxin and cardiotoxin.
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The ECG remained normal.
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Albuterol-induced hypokalemia and its potential cardiac toxicity are discussed briefly.
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All three patients had microcytic microchromic anemia with basophilic stippling of the erythrocytes, lead lines in X-ray of the knee joint and high blood lead levels.
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RESULTS: LTG was withheld, and the patient experienced a complete recovery in conjunction with reduced serum levels.
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The use of protease Inhibitors (PI) has been associated with many adverse effects including increased tendency to bleed, which is particularly problematic in individuals with congenital coagulation disorders.
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Lichen planus induced by hepatitis B vaccination: a new case and review of the literature.
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