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Physicians should be aware that indinavir nephrolithiasis may cause papillary necrosis.
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All three patients (and possibly a fourth) who developed AML were postmenopausal, received continuous chlorambucil for greater than or equal to 4 years, had acute red cell anemia at the time of treatment, and had a wbc count in the range of 2700-7700/mm3.
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Whole blood histamine release studies were negative.
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Two 65-year-old white men with coronary heart disease, given niacin therapy for dyslipidemia for 5 months, developed intense dental and gingival pain that was associated with increases in dose and that was relieved with discontinuance of niacin treatment.
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RESULTS: Two patients were obese and developed extensive abdominal wall skin necrosis.
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PLD also has a different cutaneous side effect profile than doxorubicin, and its cutaneous toxicity can be dose limiting.
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The major problems affecting compliance with pharmacotherapy for schizophrenia are outlined here showing, by means of case histories, how sertindole has benefited schizophrenic patients.
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Transient visual anomalies associated with drug treatment for spastic colon.
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No oligodendroglias with intranuclear inclusions were found.
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This article reviews current human and veterinary literature regarding the microbiology, pathogenesis, and treatment of nocardiosis and reports on the successful treatment of systemic nocardiosis in two dogs.
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Withdrawal emergent syndrome (WES) is a subtype of tardive dyskinesia that has been reported in children who were taken off antipsychotic therapy.
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We present the case of a 19-year-old male athlete with protein C deficiency who developed proximal deep venous thrombosis and pulmonary embolism while abusing anabolic-androgenic steroids.
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In conclusion, intradermal skin tests can be a useful tool for detecting a potential cross-reaction between platinum salts.
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Beriberi is the systemic counterpart of thiamine deficiency and often manifests in cardiovascular collapse.
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HRCT obtained on inspiration showed dilated thick-walled bronchioli, and innumerable centrilobular linear and branching structures in the bilateral middle and lower lobes.
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One patient who received clindamycin had liver biopsy findings of marked cholestasis, portal inflammation, bile duct injury and bile duct paucity (ductopenia).
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To our knowledge, these cases represent the first reports of TDF-associated irreversible renal failure and rickets in pediatric patients.
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Average length of stay postCDT was 7 days with no perioperative complications.
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Zolpidem (Ambien), a relatively new nonbenzodiazepine sedative-hypnotic, was involved in the death of a 39-year-old obese male who was being treated for depression and insomnia.
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We report 5 patients (3 patients with chronic hepatitis C treated with pegylated interferon alfa-2b in association with oral ribavirin and two patients with chronic myelocytic leukemia) who developed local cutaneous reactions at sites of injection after the administration of weekly subcutaneous injections of pegylated interferon alfa-2b at different doses.
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She developed congestive heart failure, and hemodialysis was initiated.
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Following discontinuation of clozapine, she was rechallenged and again was observed to have seizures.
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Cerebrovascular complications of L-asparaginase therapy in children with leukemia: aphasia and other neuropsychological deficits.
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Both were alcoholic, malnourished and presented with radiologically widespread, smear-positive disease and lymphocytopenia.
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The global spreading of chloroquine-resistant falciparum malaria brings about an increasing use of quinine.
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In contrast, after the last course of chemotherapy, which did not include M-CSF, urinary protein excretion was not enhanced.
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We describe the side effects of 5-FU in a colon cancer patient who suffered severe mucositis, desquamating dermatitis, prolonged myelosuppression, and neurologic toxicity that required admission to the intensive care unit.
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Experience with the use of cytotoxic drugs in the first trimester of pregnancy is limited.
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The patient died suddenly, and the autopsy revealed pulmonary embolism originating from the deep vein thrombosis caused by the compression of common iliac vein by the tumor.
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In early-recognized, subacute cases a surgical intervention using patches can be lifesaving.
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Naratriptan was extremely well tolerated, with no cardiovascular adverse events reported or observed.
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Clinicians should be cognizant of this possibility and consider a diagnosis of HDAs in patients with ongoing thrombosis who are receiving heparin therapy.
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Serial radiographic observation over two months.
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Safety and efficacy of S-1 chemotherapy in recurrent/metastatic head and neck cancer.
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On this regime, together with supportive psychotherapy, she experienced a sense of emotional well-being, exhibited a good level of functioning and maintained a safe body weight.
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Colonic necrosis is known as a rare complication following the administration of Kayexalate (sodium polystryrene sulfonate) in sorbitol.
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A 50-year-old woman with a history of migraine without aura, predominantly occurring around her menstrual periods, developed a spinal cord lesion following the use of zolmitriptan.
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She was subsequently admitted to hospital and was diagnosed as having nephrotic syndrome.
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We present a surprising case of a woman schizophrenic patient treated with clozapine suffering from EPS.
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However, the patient became steroid-dependent and experienced recurrent optic neuritis during multiple attempts at tapering the steroids.
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A platelet autoantibody could not be detected by a radioactive platelet antiglobulin test, but autologous platelet survival data indicated a compensated thrombolytic state in the recovery period.
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We describe a Caucasian child who initially presented with clinical and histopathologic features consistent with inflammatory bowel disease, for whom additional investigations led to the diagnosis of severe chronic active Epstein-Barr virus infection.
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These cases were chosen for study because they were all deaths as a result of suicidal ingestion of drugs in which quetiapine was considered a significant factor.
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Despite the widespread use of beta-sympathomimetic agents for preterm labour there appears to be a limited appreciation of the need for cardiovascular monitoring in the mother.
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Four weeks later, a coronary arteriogram showed only minimal luminal irregularities at the original site of occlusion, where significant reduction in diameter could be induced by ergonovine maleate.
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The patient was admitted to the emergency department of a local hospital within two days due to ongoing headache, elevated temperature, and nuchal rigidity, symptoms suggestive of meningitis.
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The diagnosis was made on the basis of inflammatory changes in the cerebral spinal fluid and localization of the abscess by means of computer and magnetic resonance tomography.
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Combined thrombolytic therapy for prosthetic mitral valve thrombosis.
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The principle treatment for DPD-deficient patients with severe acute 5-FU reactions is supportive care; however, the administration of thymidine potentially may reverse severe 5-FU-induced neurologic symptoms such as encephalopathy and coma.
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CONCLUSION: This side effect, apparently unique to bupropion among antidepressants, may be mediated through dopaminergic effects in the basal ganglia.
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Atypical antipsychotics have reduced liability for inducing tardive dystonia and show antidystonic properties in patients with pre-existing tardive dystonia.
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A difference in chemical structure between these two drugs, particularly of a sulfur moiety, may help explain why the drug-induced disease did not recur.
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Nonopioid analgesics did not relieve her pain, and she was unable to walk without the aid of a walker.
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Posttransplant lymphoproliferative disorder of the nasopharynx.
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There is no known effective therapy for PEComa, and the molecular pathophysiology of aberrant mTOR signaling provided us with a scientific rationale to target this pathway therapeutically.
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Possible explanations of this ocular effect are offered: pharmacokinetic interference on the drugs used in glaucoma treatment, in vivo action on the muscarinic receptor, indirect effect via dopaminergic receptors, or direct effect on the ocular sympathetic postganglionic neurones.
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Both patients completely recovered after transient pancytopenia, but showed severe and intermediate neutropenia (0.216 and 0.768 x 10(9)/l, respectively) at the nadirs of aplastic crises.
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Twenty-one days of magnesium sulfate tocolysis were performed on a 28-year-old woman because of preterm labor at 31 weeks gestation.
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Cardiac function and symptoms recovered completely.
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Glucocorticoids in early rheumatoid arthritis.
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It is concluded that simultaneous administration of ciprofloxacin and tazobactam/piperacillin may cause marked thrombocytosis.
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Direct immunofluorescence revealed staining at the dermal-epidermal junction and around blood vessels with IgG in the first case and with IgG, IgA, and fibrin in the second case.
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Graft-versus-host disease was seen only in 41% of the bone marrow recipients.
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A physical and/or chemical in vitro compatibility of 5-FU and calcium folinic acid, without validated clinical data is not sufficient to use this mixture in routine clinical practice.
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CLINICAL FEATURES: The patient was a 22-yr-old obese man with metastatic testicular carcinoma who underwent a left-sided thoracoabdominal retroperitoneal tumour resection.
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Two cases of polymorphic ventricular tachycardia induced by the administration of verapamil against paroxysmal supraventricular tachycardia.
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CASE: We herein report the case of a 67-year-old woman with a history of breast cancer, taking tamoxifen citrate 20 mg/day for 4 years, who underwent an operation for left ovarian tumor.
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The symptoms started when the immune status reached normal CD4 T cell levels, in response to antiviral tritherapy.
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Imaging confirmed this excellent response.
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A 65-year-old female patient presented with jaundice followed 2 days later by severe dyspnea and tachypnea which worsened when patient was lying flat, 1 week after the fourth dose of adalimumab.
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Chemotherapy was stopped and systemic application of prednisolone was initiated.
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Hepatotoxicity seen with erlotinib, a small molecule tyrosine kinase inhibitor to EGFR, is usually transient with mild elevation of transaminases.
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In each case, brief periods (5 to 20 seconds) of rapid atrial pacing were effective in terminating the supraventricular tachycardia and resulted in a return to normal sinus rhythm.
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This encouraging result suggests that BMT from an unrelated donor should be considered for ATL even if the disease is refractory to chemotherapy.
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Clinicians are advised to observe for symptoms of toxicity and to do serial blood levels to monitor this interaction.
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This is known as a PSA "bounce" or "bump." Some patients experience a second transient rise in PSA levels after irradiation.
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She rapidly developed profound CNS depression with stupor, hypothermia, hypoventilation and bradycardia.
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On her next anticoagulation clinic visit, the patient's INR had increased, although the dosage of warfarin had been reduced when the tolterodine had been prescribed.
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We conclude that autoimmune hemolytic anemia may be an unusual presentation for postirradiation sarcoma.
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A 7-year-old girl developed diabetes mellitus and exocrine pancreatic insufficiency after 3.5 years of almost continuous treatment with azathioprine and/or prednisone for idiopathic auto-immune haemolytic anaemia.
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Rapid cycling in manic-depressives induced by tricyclic antidepressants.
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A bone marrow aspiration test on day 16 showed a markedly increased number of activated macrophages showing massive hemophagocytosis.
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Little is known about the behaviour of endogenous thrombopoietin (TPO) serum levels during rapid sequences of dose-intensified chemotherapy.
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CASE SUMMARY: A 50-year-old white woman with a history of advanced breast cancer refractory to other treatment modalities was receiving vinorelbine.
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Infected graft transplantation is an unwelcome complication that may lead to serious consequences in the immunosuppressed host.
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MH was treated immediately with dantrolene; the patient recovered within 14 days.
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He was discharged on March 15; myoclonic muscle spasms began that afternoon.
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The case suggests that mechanical valve replacement may not prevent gastrointestinal bleeding in Heyde syndrome and that octreotide treatment should be considered in these cases.
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The diagnosis can be accurately made with axial computed tomography (CT) of the involved spinal segment.
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The clinical features and management of this combined intoxication are discussed.
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Treatment with topical antibiotic agents did not improve the symptoms.
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This is the first report of successful utilization of the prepuce as a skin graft to reconstruct a full thickness skin necrosis due to a phenobarbital extravasation to the forefoot of a newborn.
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Pseudomonas corneal ulcer after use of extended-wear rigid gas-permeable contact lens.
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The skin lesions were eczematoid patches, flaccid bullae and crusted plaques on the trunk and extremities, histologically showing a high epidermal blister with acantholysis.
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We present a 20-year-old woman with Basedow-Graves' disease who developed PTU-induced fulminant hepatitis, which progressed to acute hepatic failure with grade III hepatic encephalopathy.
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However, the electroretinogram was abnormal on several occasions during therapy with rifabutin, but returned to normal 3 months after withdrawal of the medication.
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We have described three patients with hepatitis C for whom IFN-alpha and ribavirin were prescribed and who developed two successive phases of silent thyroiditis followed by hyperthryroidism relapse due to Graves' disease.
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CONCLUSIONS: There was a temporal relationship between the onset of nonconvulsive status epilepticus and initiation of ifosfamide infusion.
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Photosensitive reflex epilepsy is provoked by environmental flicker stimuli.
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Objective causality assessment revealed that the adverse event was probably drug induced.
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