id
stringlengths 1
5
| tokens
sequence | ner_tags
sequence |
---|---|---|
5001 | [
"Thus",
",",
"A-myb",
"expression",
",",
"unlike",
"that",
"of",
"c-myb",
"and",
"B-myb",
",",
"is",
"restricted",
"to",
"a",
"subset",
"of",
"B-cell",
"neoplasias",
"(",
"in",
"particular",
"BL",
"and",
"slg+B-ALL",
")",
"representative",
"of",
"a",
"specific",
"stage",
"of",
"B-cell",
"differentiation",
"."
] | [
0,
0,
1,
0,
0,
0,
0,
0,
1,
0,
1,
0,
0,
0,
0,
0,
0,
0,
7,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
7,
0,
0
] |
5002 | [
"This",
"expression",
"may",
"in",
"part",
"reflect",
"expression",
"of",
"A-myb",
"by",
"the",
"normal",
"germinal",
"center",
"B",
"cells",
"that",
"are",
"the",
"normal",
"counterpart",
"of",
"these",
"transformed",
"B",
"cells",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
1,
0,
0,
0,
7,
8,
8,
8,
0,
0,
0,
0,
0,
0,
0,
0,
7,
8,
0
] |
5003 | [
"The",
"data",
"presented",
"strongly",
"support",
"a",
"role",
"for",
"this",
"transcription",
"factor",
"in",
"B-cell",
"differentiation",
"and",
"perhaps",
"in",
"B-cell",
"transformation",
"in",
"some",
"neoplasias",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
7,
0,
0,
0,
0,
7,
0,
0,
0,
0,
0
] |
5004 | [
"Granulocyte-macrophage",
"colony-stimulating",
"factor",
"stimulates",
"JAK2",
"signaling",
"pathway",
"and",
"rapidly",
"activates",
"p93fes",
",",
"STAT1",
"p91",
",",
"and",
"STAT3",
"p92",
"in",
"polymorphonuclear",
"leukocytes",
"."
] | [
9,
10,
10,
0,
9,
0,
0,
0,
0,
0,
9,
0,
9,
10,
0,
0,
9,
10,
0,
7,
8,
0
] |
5005 | [
"Granulocyte-macrophage",
"colony-stimulating",
"factor",
"(",
"GM-CSF",
")",
",",
"supports",
"proliferation",
",",
"differentiation",
",",
"and",
"functional",
"activation",
"of",
"hemopoietic",
"cells",
"by",
"its",
"interaction",
"with",
"a",
"heterodimeric",
"receptor",
"."
] | [
9,
10,
10,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
7,
8,
0,
0,
0,
0,
0,
0,
0,
0
] |
5006 | [
"Although",
"GM-CSF",
"receptor",
"is",
"devoid",
"of",
"tyrosine",
"kinase",
"enzymatic",
"activity",
",",
"GM-CSF-induced",
"peripheral",
"blood",
"polymorphonuclear",
"leukocytes",
"(",
"PMN",
")",
"functional",
"activation",
"is",
"mediated",
"by",
"the",
"phosphorylation",
"of",
"a",
"large",
"number",
"of",
"intracellular",
"signaling",
"molecules",
"."
] | [
0,
9,
10,
0,
0,
0,
9,
10,
0,
0,
0,
0,
7,
8,
8,
8,
0,
7,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
5007 | [
"We",
"have",
"previously",
"shown",
"that",
"JAK2",
"becomes",
"tyrosine-phosphorylated",
"in",
"response",
"to",
"GM-CSF",
"in",
"PMN",
"."
] | [
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
9,
0,
7,
0
] |
5008 | [
"In",
"the",
"present",
"study",
"we",
"demonstrate",
"that",
"also",
"the",
"signal",
"transducers",
"and",
"activators",
"of",
"transcription",
"(",
"STAT",
")",
"family",
"members",
"STAT1",
"p91",
"and",
"STAT3",
"p92",
"and",
"the",
"product",
"of",
"the",
"c-fps/fes",
"protooncogene",
"become",
"tyrosine-phosphorylated",
"upon",
"GM-CSF",
"stimulation",
"and",
"physically",
"associated",
"with",
"both",
"GM-CSF",
"receptor",
"beta",
"common",
"subunit",
"and",
"JAK2",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
10,
10,
10,
10,
10,
10,
10,
10,
10,
9,
10,
0,
9,
10,
0,
0,
0,
0,
0,
1,
2,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
9,
10,
10,
0,
0,
0,
9,
0
] |
5009 | [
"Moreover",
"GM-CSF",
"was",
"able",
"to",
"induce",
"JAK2",
"and",
"p93fes",
"catalytic",
"activity",
"."
] | [
0,
9,
0,
0,
0,
0,
9,
0,
9,
0,
0,
0
] |
5010 | [
"We",
"also",
"demonstrate",
"that",
"the",
"association",
"of",
"the",
"GM-CSF",
"receptor",
"beta",
"common",
"subunit",
"with",
"JAK2",
"is",
"ligand-dependent",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
10,
0,
0,
0,
9,
0,
0,
0
] |
5011 | [
"Finally",
"we",
"demonstrate",
"that",
"GM-CSF",
"induces",
"a",
"DNA-binding",
"complex",
"that",
"contains",
"both",
"p91",
"and",
"p92",
"."
] | [
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
9,
0,
9,
0
] |
5012 | [
"These",
"results",
"identify",
"a",
"new",
"signal",
"transduction",
"pathway",
"activated",
"by",
"GM-CSF",
"and",
"provide",
"a",
"mechanism",
"for",
"rapid",
"activation",
"of",
"gene",
"expression",
"in",
"GM-CSF-stimulated",
"PMN",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
7,
0
] |
5013 | [
"Epstein-Barr",
"virus",
"nuclear",
"antigen",
"2",
"(",
"EBNA2",
")",
"-oestrogen",
"receptor",
"fusion",
"proteins",
"complement",
"the",
"EBNA2-deficient",
"Epstein-Barr",
"virus",
"strain",
"P3HR1",
"in",
"transformation",
"of",
"primary",
"B",
"cells",
"but",
"suppress",
"growth",
"of",
"human",
"B",
"cell",
"lymphoma",
"lines",
"."
] | [
9,
10,
10,
10,
10,
10,
10,
10,
10,
10,
10,
10,
0,
0,
0,
0,
0,
0,
5,
0,
0,
0,
0,
7,
8,
0,
0,
0,
0,
5,
6,
6,
6,
6,
0
] |
5014 | [
"To",
"develop",
"a",
"transformation",
"system",
"with",
"a",
"conditional",
"Epstein-Barr",
"virus",
"nuclear",
"antigen",
"2",
"(",
"EBNA2",
")",
"gene",
",",
"we",
"fused",
"the",
"hormone",
"binding",
"domain",
"of",
"the",
"oestrogen",
"receptor",
"to",
"the",
"N",
"or",
"C",
"terminus",
"of",
"EBNA2",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
2,
2,
2,
2,
2,
2,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
0,
0,
0,
0,
0,
0,
0,
9,
0
] |
5015 | [
"In",
"promoter",
"transactivation",
"as",
"well",
"as",
"primary",
"B",
"cell",
"transformation",
"assays",
"these",
"chimeric",
"EBNA2",
"proteins",
"are",
"able",
"to",
"substitute",
"for",
"wild-type",
"EBNA2",
"in",
"the",
"presence",
"of",
"oestrogen",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
7,
8,
0,
0,
0,
0,
9,
10,
0,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0
] |
5016 | [
"Here",
"we",
"provide",
"evidence",
"that",
"this",
"transformation",
"is",
"the",
"result",
"of",
"double",
"infection",
"of",
"a",
"cell",
"with",
"two",
"virions",
",",
"the",
"P3HR1",
"virus",
"genome",
"and",
"a",
"mini-EBV",
"plasmid",
"carrying",
"the",
"chimeric",
"EBNA2",
"gene",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
5,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
0
] |
5017 | [
"Unexpectedly",
",",
"expression",
"of",
"the",
"same",
"EBNA2",
"-oestrogen",
"receptor",
"fusion",
"protein",
"in",
"established",
"human",
"B",
"cell",
"lymphoma",
"lines",
"resulted",
"in",
"growth",
"retardation",
"or",
"growth",
"arrest",
"upon",
"the",
"addition",
"of",
"oestrogen",
"."
] | [
0,
0,
0,
0,
0,
0,
9,
10,
10,
10,
10,
0,
0,
5,
6,
6,
6,
6,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
5018 | [
"By",
"titrating",
"the",
"oestrogen",
"concentration",
"in",
"these",
"stably",
"transfected",
"cells",
",",
"the",
"growth",
"retarding",
"and",
"the",
"transactivating",
"function",
"of",
"the",
"chimeric",
"proteins",
"could",
"not",
"be",
"dissociated",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
5019 | [
"We",
"propose",
"that",
"growth",
"inhibition",
"of",
"established",
"B",
"cell",
"lymphoma",
"lines",
"is",
"a",
"novel",
"function",
"of",
"EBNA2",
"which",
"has",
"not",
"been",
"detected",
"in",
"the",
"absence",
"of",
"an",
"inducible",
"system",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
5,
6,
6,
6,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
5020 | [
"It",
"remains",
"open",
"whether",
"the",
"growth",
"retarding",
"property",
"of",
"the",
"EBNA2-oestrogen",
"receptor",
"fusion",
"protein",
"in",
"B",
"cell",
"lymphoma",
"lines",
"is",
"due",
"to",
"unphysiologically",
"high",
"expression",
"of",
"the",
"chimeric",
"protein",
"or",
"to",
"interference",
"with",
"a",
"cellular",
"programme",
"driving",
"proliferation",
"in",
"these",
"cell",
"lines",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
10,
10,
0,
5,
6,
6,
6,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
5021 | [
"Tissue-specific",
"activity",
"of",
"the",
"gammac",
"chain",
"gene",
"promoter",
"depends",
"upon",
"an",
"Ets",
"binding",
"site",
"and",
"is",
"regulated",
"by",
"GA-binding",
"protein",
"."
] | [
0,
0,
0,
0,
1,
2,
2,
2,
0,
0,
0,
1,
2,
2,
0,
0,
0,
0,
9,
10,
0
] |
5022 | [
"The",
"gammac",
"chain",
"is",
"a",
"subunit",
"of",
"multiple",
"cytokine",
"receptors",
"(",
"interleukin",
"(",
"IL",
")",
"-2",
",",
"IL-4",
",",
"IL-7",
",",
"IL-9",
",",
"and",
"IL-15",
")",
",",
"the",
"expression",
"of",
"which",
"is",
"restricted",
"to",
"hematopoietic",
"lineages",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
10,
10,
10,
0,
9,
0,
9,
0,
9,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
7,
8,
0
] |
5023 | [
"A",
"defect",
"in",
"gammac",
"leads",
"to",
"the",
"X-linked",
"severe",
"combined",
"immunodeficiency",
"characterized",
"by",
"a",
"block",
"in",
"T",
"cell",
"differentiation",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
7,
8,
0,
0
] |
5024 | [
"In",
"order",
"to",
"better",
"characterize",
"the",
"human",
"gammac",
"promoter",
"and",
"define",
"the",
"minimal",
"tissue-specific",
"promoter",
"region",
",",
"progressive",
"5'-deletion",
"constructs",
"of",
"a",
"segment",
"extending",
"1053",
"base",
"pairs",
"upstream",
"of",
"the",
"major",
"transcription",
"start",
"site",
"were",
"generated",
"and",
"tested",
"for",
"promoter",
"activity",
"in",
"various",
"hematopoietic",
"and",
"nonhematopoietic",
"cell",
"types",
"."
] | [
0,
0,
0,
0,
0,
0,
1,
2,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
7,
8,
0,
0
] |
5025 | [
"The",
"-1053/+34",
"construct",
"allowed",
"promoter",
"activity",
"only",
"in",
"cells",
"of",
"hematopoietic",
"origin",
",",
"and",
"tissue",
"specificity",
"was",
"conserved",
"in",
"all",
"other",
"constructs",
"tested",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
5026 | [
"The",
"region",
"downstream",
"of",
"-90",
"appeared",
"critical",
"for",
"basal",
"promoter",
"activity",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
5027 | [
"It",
"contains",
"two",
"potential",
"Ets",
"binding",
"sites",
"conserved",
"in",
"the",
"murine",
"gammac",
"promoter",
"gene",
",",
"one",
"of",
"which",
"was",
"found",
"essential",
"for",
"functional",
"promoter",
"activity",
"as",
"determined",
"by",
"mutational",
"analysis",
"."
] | [
0,
0,
0,
0,
1,
2,
2,
0,
0,
0,
1,
2,
2,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
5028 | [
"The",
"functional",
"Ets",
"binding",
"site",
"was",
"found",
"to",
"bind",
"Ets",
"family",
"proteins",
",",
"principally",
"GA-binding",
"protein",
"and",
"Elf-1",
"and",
"could",
"be",
"transactivated",
"by",
"GABPalpha",
"and",
"-beta",
"synergistically",
"."
] | [
0,
0,
1,
2,
2,
0,
0,
0,
0,
9,
10,
10,
0,
0,
9,
10,
0,
9,
0,
0,
0,
0,
0,
9,
0,
9,
0,
0
] |
5029 | [
"These",
"results",
"indicate",
"that",
",",
"as",
"already",
"reported",
"for",
"the",
"IL2Rbeta",
"promoter",
",",
"GA-binding",
"protein",
"is",
"an",
"essential",
"component",
"of",
"gammac",
"basal",
"promoter",
"activity",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
0,
9,
10,
0,
0,
0,
0,
0,
1,
2,
2,
0,
0
] |
5030 | [
"Although",
"GABP",
"expression",
"is",
"not",
"restricted",
"to",
"the",
"hematopoietic",
"lineage",
",",
"its",
"interaction",
"with",
"other",
"specific",
"factors",
"may",
"contribute",
"to",
"the",
"tissue-specific",
"expression",
"of",
"the",
"gammac",
"gene",
"."
] | [
0,
9,
0,
0,
0,
0,
0,
0,
7,
8,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
0
] |
5031 | [
"Detection",
"of",
"intracellular",
"signal",
"transduction",
"molecules",
"in",
"PBMC",
"from",
"rhesus",
"macaques",
"and",
"sooty",
"mangabeys",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
7,
0,
0,
0,
0,
0,
0,
0
] |
5032 | [
"One",
"of",
"the",
"manifestations",
"of",
"human",
"HIV-1",
"and",
"nonhuman",
"primate",
"SIV",
"infection",
"that",
"lead",
"to",
"disease",
"is",
"reasoned",
"to",
"be",
"secondary",
"to",
"generalized",
"T-cell",
"dysfunction",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
7,
0,
0
] |
5033 | [
"The",
"molecular",
"mechanisms",
"associated",
"with",
"the",
"T-cell",
"dysfunction",
"remain",
"to",
"be",
"elucidated",
"."
] | [
0,
0,
0,
0,
0,
0,
7,
0,
0,
0,
0,
0,
0
] |
5034 | [
"To",
"address",
"this",
"issue",
",",
"we",
"sought",
"to",
"utilize",
"the",
"nonhuman",
"primate",
"model",
"to",
"study",
"intracellular",
"signaling",
"events",
"in",
"cells",
"from",
"disease-susceptible",
"rhesus",
"macaques",
"and",
"disease-resistant",
"sooty",
"mangabeys",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
5035 | [
"Because",
"relatively",
"little",
"is",
"known",
"about",
"these",
"events",
"in",
"nonhuman",
"primates",
",",
"our",
"laboratory",
"defined",
"optimal",
"conditions",
",",
"reagents",
",",
"and",
"assays",
"for",
"the",
"study",
"of",
"signal",
"transduction",
"events",
"in",
"cells",
"from",
"nonhuman",
"primates",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
5036 | [
"The",
"protein",
"phosphorylation",
"patterns",
"in",
"the",
"two",
"monkeys",
"exhibited",
"quantitative",
",",
"qualitative",
",",
"and",
"kinetic",
"differences",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
5037 | [
"Antibodies",
"to",
"Stat6",
"detected",
"a",
"unique",
"band",
"in",
"macaque",
"cell",
"lysates",
"."
] | [
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
5038 | [
"This",
"band",
"is",
"markedly",
"decreased",
"human",
"cell",
"lysates",
"and",
"never",
"seen",
"in",
"mangabey",
"cell",
"lysates",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
5039 | [
"Detection",
"of",
"various",
"other",
"intracellular",
"signaling",
"proteins",
"is",
"also",
"described",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
5040 | [
"Genetic",
"characterization",
"of",
"transactivation",
"of",
"the",
"human",
"T-cell",
"leukemia",
"virus",
"type",
"1",
"promoter",
":",
"Binding",
"of",
"Tax",
"to",
"Tax-responsive",
"element",
"1",
"is",
"mediated",
"by",
"the",
"cyclic",
"AMP-responsive",
"members",
"of",
"the",
"CREB/ATF",
"family",
"of",
"transcription",
"factors",
"."
] | [
0,
0,
0,
0,
0,
0,
1,
2,
2,
2,
2,
2,
2,
0,
0,
0,
9,
0,
1,
2,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
0,
0,
0,
0
] |
5041 | [
"To",
"achieve",
"a",
"better",
"understanding",
"of",
"the",
"mechanism",
"of",
"transactivation",
"by",
"Tax",
"of",
"human",
"T-cell",
"leukemia",
"virus",
"type",
"1",
"Tax-responsive",
"element",
"1",
"(",
"TRE-1",
")",
",",
"we",
"developed",
"a",
"genetic",
"approach",
"with",
"Saccharomyces",
"cerevisiae",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
1,
2,
2,
0,
1,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
5042 | [
"We",
"constructed",
"a",
"yeast",
"reporter",
"strain",
"containing",
"the",
"lacZ",
"gene",
"under",
"the",
"control",
"of",
"the",
"CYC1",
"promoter",
"associated",
"with",
"three",
"copies",
"of",
"TRE-1",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
0,
0,
0,
0,
0,
1,
2,
0,
0,
0,
0,
0,
1,
0
] |
5043 | [
"Expression",
"of",
"either",
"the",
"cyclic",
"AMP",
"response",
"element-binding",
"protein",
"(",
"CREB",
")",
"or",
"CREB",
"fused",
"to",
"the",
"GAL4",
"activation",
"domain",
"(",
"GAD",
")",
"in",
"this",
"strain",
"did",
"not",
"modify",
"the",
"expression",
"of",
"the",
"reporter",
"gene",
"."
] | [
0,
0,
0,
0,
9,
10,
10,
10,
10,
0,
9,
0,
0,
9,
0,
0,
0,
9,
10,
10,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
5044 | [
"Tax",
"alone",
"was",
"also",
"inactive",
"."
] | [
9,
0,
0,
0,
0,
0
] |
5045 | [
"However",
",",
"expression",
"of",
"the",
"reporter",
"gene",
"was",
"induced",
"by",
"coexpression",
"of",
"Tax",
"and",
"CREB",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
9,
0
] |
5046 | [
"This",
"effect",
"was",
"stronger",
"with",
"the",
"GAD-CREB",
"fusion",
"protein",
"."
] | [
0,
0,
0,
0,
0,
0,
9,
10,
10,
0
] |
5047 | [
"Analysis",
"of",
"different",
"CREB",
"mutants",
"with",
"this",
"genetic",
"system",
"indicated",
"that",
"the",
"C-terminal",
"92",
"amino",
"acid",
"residues",
",",
"which",
"include",
"the",
"basic",
"domain",
"and",
"the",
"leucine",
"zipper",
",",
"are",
"necessary",
"and",
"sufficient",
"to",
"mediate",
"transactivation",
"by",
"Tax",
"."
] | [
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0
] |
5048 | [
"To",
"identify",
"cellular",
"proteins",
"binding",
"to",
"TRE-1",
"in",
"a",
"Tax",
"-dependent",
"manner",
",",
"this",
"strain",
"was",
"also",
"used",
"to",
"screen",
"a",
"library",
"of",
"human",
"cDNAs",
"fused",
"to",
"GAD",
"."
] | [
0,
0,
0,
0,
0,
0,
1,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0
] |
5049 | [
"Of",
"five",
"positive",
"clones",
"isolated",
"from",
"0.75",
"x",
"10",
"(",
"6",
")",
"yeast",
"colonies",
",",
"four",
"were",
"members",
"of",
"the",
"CREB/activating",
"transcription",
"factor",
"(",
"ATF",
")",
"family",
":",
"CREB",
",",
"two",
"isoforms",
"of",
"the",
"cyclic",
"AMP-responsive",
"element",
"modulator",
"(",
"CREM",
")",
",",
"and",
"ATF-1",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
10,
10,
10,
10,
10,
0,
9,
0,
0,
0,
0,
0,
9,
10,
10,
10,
0,
9,
0,
0,
0,
9,
0
] |
5050 | [
"Interestingly",
",",
"these",
"three",
"proteins",
"can",
"be",
"phosphorylated",
"by",
"protein",
"kinase",
"A",
"and",
"thus",
"form",
"a",
"particular",
"subgroup",
"within",
"the",
"CREB/ATF",
"family",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
10,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
0
] |
5051 | [
"Expression",
"of",
"ATF-2",
"in",
"S.",
"cerevisiae",
"did",
"not",
"activate",
"TRE-1",
"in",
"the",
"presence",
"of",
"Tax",
"."
] | [
0,
0,
9,
0,
0,
0,
0,
0,
0,
1,
0,
0,
0,
0,
9,
0
] |
5052 | [
"This",
"shows",
"that",
"in",
"a",
"eukaryotic",
"nucleus",
",",
"Tax",
"specifically",
"interacts",
"with",
"the",
"basic",
"domain-leucine",
"zipper",
"region",
"of",
"ATF-1",
",",
"CREB",
",",
"and",
"CREM",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
9,
0,
0,
9,
0
] |
5053 | [
"The",
"fifth",
"clone",
"identified",
"in",
"this",
"screening",
"corresponded",
"to",
"the",
"Ku",
"autoantigen",
"p70",
"subunit",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
10,
10,
0
] |
5054 | [
"When",
"fused",
"to",
"GAD",
",",
"the",
"C-terminal",
"region",
"of",
"Ku",
"was",
"able",
"to",
"activate",
"transcription",
"via",
"TRE-1",
"but",
"this",
"activation",
"was",
"not",
"dependent",
"on",
"Tax",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
1,
0,
0,
0,
0,
0,
0,
0,
9,
0
] |
5055 | [
"A",
"mammalian",
"histone",
"deacetylase",
"related",
"to",
"the",
"yeast",
"transcriptional",
"regulator",
"Rpd3p",
"[",
"see",
"comments",
"]"
] | [
0,
9,
10,
10,
0,
0,
0,
9,
10,
10,
10,
0,
0,
0,
0
] |
5056 | [
"Trapoxin",
"is",
"a",
"microbially",
"derived",
"cyclotetrapeptide",
"that",
"inhibits",
"histone",
"deacetylation",
"in",
"vivo",
"and",
"causes",
"mammalian",
"cells",
"to",
"arrest",
"in",
"the",
"cell",
"cycle",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
5057 | [
"A",
"trapoxin",
"affinity",
"matrix",
"was",
"used",
"to",
"isolate",
"two",
"nuclear",
"proteins",
"that",
"copurified",
"with",
"histone",
"deacetylase",
"activity",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
0,
0
] |
5058 | [
"Both",
"proteins",
"were",
"identified",
"by",
"peptide",
"microsequencing",
",",
"and",
"a",
"complementary",
"DNA",
"encoding",
"the",
"histone",
"deacetylase",
"catalytic",
"subunit",
"(",
"HD1",
")",
"was",
"cloned",
"from",
"a",
"human",
"Jurkat",
"T",
"cell",
"library",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
10,
10,
0,
9,
0,
0,
0,
0,
0,
5,
6,
6,
6,
0,
0
] |
5059 | [
"As",
"the",
"predicted",
"protein",
"is",
"very",
"similar",
"to",
"the",
"yeast",
"transcriptional",
"regulator",
"Rpd3p",
",",
"these",
"results",
"support",
"a",
"role",
"for",
"histone",
"deacetylase",
"as",
"a",
"key",
"regulator",
"of",
"eukaryotic",
"transcription",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
10,
10,
0,
0,
0,
0,
0,
0,
0,
9,
10,
0,
0,
0,
0,
0,
0,
0,
0
] |
5060 | [
"Coexpression",
"of",
"the",
"interleukin-13",
"and",
"interleukin-4",
"genes",
"correlates",
"with",
"their",
"physical",
"linkage",
"in",
"the",
"cytokine",
"gene",
"cluster",
"on",
"human",
"chromosome",
"5q23-31",
"."
] | [
0,
0,
0,
1,
0,
1,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
2,
0
] |
5061 | [
"Interleukin-13",
"(",
"IL-13",
")",
"and",
"IL-4",
"are",
"cytokines",
"produced",
"by",
"T",
"cells",
"that",
"are",
"encoded",
"by",
"the",
"q23-31",
"region",
"of",
"human",
"chromosome",
"5",
"."
] | [
9,
0,
9,
0,
0,
9,
0,
0,
0,
0,
7,
8,
0,
0,
0,
0,
0,
1,
0,
0,
1,
2,
2,
0
] |
5062 | [
"To",
"investigate",
"the",
"regulation",
"of",
"IL-13",
"gene",
"expression",
"by",
"T",
"cells",
",",
"we",
"isolated",
"and",
"sequenced",
"the",
"human",
"IL-13",
"gene",
",",
"analyzed",
"its",
"5'-flanking",
"region",
"for",
"potential",
"transcriptional",
"activation",
"elements",
",",
"and",
"examined",
"its",
"expression",
"in",
"nontransformed",
"T-lineage",
"cell",
"populations",
"."
] | [
0,
0,
0,
0,
0,
1,
2,
0,
0,
7,
8,
0,
0,
0,
0,
0,
0,
1,
2,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
7,
8,
0,
0
] |
5063 | [
"The",
"human",
"IL-13",
"gene",
"was",
"located",
"12.5-kb",
"upstream",
"of",
"the",
"IL-4",
"gene",
"and",
"2-kb",
"downstream",
"of",
"a",
"CpG",
"island",
"."
] | [
0,
1,
2,
2,
0,
0,
0,
0,
0,
0,
1,
2,
0,
0,
0,
0,
0,
0,
0,
0
] |
5064 | [
"The",
"IL-13",
"gene",
"5",
"'",
"flank",
"region",
"included",
"a",
"segment",
"with",
"sequence",
"homology",
"to",
"P",
"elements",
"of",
"the",
"IL-4",
"promoter",
"involved",
"in",
"transcriptional",
"activation",
"in",
"T",
"cells",
"."
] | [
0,
1,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
0,
0,
0,
0,
0,
7,
8,
0
] |
5065 | [
"Mutation",
"of",
"the",
"IL-13",
"P",
"element",
"site",
"significantly",
"reduced",
"IL-13",
"promoter",
"activity",
"in",
"response",
"to",
"T-cell",
"activation",
"."
] | [
0,
0,
0,
1,
2,
2,
2,
0,
0,
1,
2,
0,
0,
0,
0,
7,
0,
0
] |
5066 | [
"Oligonucleotides",
"containing",
"the",
"IL-13",
"or",
"IL-4",
"P",
"element",
"sites",
"specifically",
"bound",
"the",
"transcriptional",
"activator",
"protein",
",",
"nuclear",
"factor-activated",
"T",
"cells",
",",
"preformed",
"(",
"NF-ATp",
")",
",",
"when",
"incubated",
"with",
"nuclear",
"protein",
"extracts",
"from",
"activated",
"T",
"cells",
"."
] | [
0,
0,
0,
1,
0,
1,
2,
2,
2,
0,
0,
0,
0,
0,
0,
0,
9,
10,
10,
10,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
7,
8,
0
] |
5067 | [
"Similar",
"to",
"IL-4",
",",
"IL-13",
"mRNA",
"expression",
"was",
"highest",
"in",
"T-cell",
"populations",
"enriched",
"for",
"cells",
"that",
"had",
"previously",
"been",
"primed",
"in",
"vivo",
"or",
"in",
"vitro",
",",
"indicating",
"that",
"priming",
"increases",
"the",
"expression",
"of",
"the",
"IL-13",
"and",
"IL-4",
"genes",
"in",
"a",
"coordinate",
"manner",
"."
] | [
0,
0,
9,
0,
3,
4,
0,
0,
0,
0,
7,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
0,
1,
2,
0,
0,
0,
0,
0
] |
5068 | [
"Because",
"the",
"primed",
"T",
"cells",
"contain",
"higher",
"levels",
"of",
"nuclear",
"NF-ATp",
",",
"capable",
"of",
"binding",
"to",
"P",
"elements",
"of",
"the",
"IL-4",
"and",
"IL-13",
"promoters",
",",
"than",
"do",
"freshly-isolated",
"T",
"cells",
",",
"the",
"NF-AT-binding",
"P",
"elements",
"are",
"attractive",
"candidates",
"to",
"mediate",
"the",
"coordinate",
"expression",
"of",
"these",
"two",
"cytokine",
"genes",
"."
] | [
0,
0,
0,
7,
8,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
0,
1,
2,
0,
0,
0,
0,
7,
8,
0,
0,
1,
2,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
5069 | [
"Inhibition",
"of",
"alpha",
"interferon",
"but",
"not",
"gamma",
"interferon",
"signal",
"transduction",
"by",
"phorbol",
"esters",
"is",
"mediated",
"by",
"a",
"tyrosine",
"phosphatase",
"."
] | [
0,
0,
9,
10,
0,
0,
9,
10,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
0
] |
5070 | [
"Previous",
"studies",
"have",
"indicated",
"that",
"the",
"expression",
"of",
"viral",
"oncoproteins",
",",
"cell",
"transformation",
",",
"or",
"phorbol",
"ester",
"treatment",
"of",
"cells",
"can",
"inhibit",
"alpha/beta",
"interferon",
"(",
"IFN-alpha/beta",
")",
"-induced",
"gene",
"expression",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
0,
9,
0,
0,
0,
0,
0
] |
5071 | [
"The",
"mechanisms",
"by",
"which",
"these",
"promoters",
"of",
"cell",
"growth",
"exert",
"their",
"inhibitory",
"effects",
"vary",
",",
"but",
"in",
"most",
"instances",
"they",
"involve",
"a",
"disruption",
"of",
"the",
"IFN-alpha/beta-induced",
"transcription",
"complex",
"ISGF3",
"such",
"that",
"the",
"DNA-binding",
"component",
"of",
"this",
"complex",
"(",
"the",
"48-kDa",
"ISGF3gamma",
"protein",
")",
"does",
"not",
"bind",
"to",
"the",
"interferon-stimulated",
"response",
"element",
"(",
"ISRE",
")",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
10,
0,
0,
0,
0,
0,
0,
1,
2,
2,
0,
1,
0,
0
] |
5072 | [
"In",
"this",
"report",
",",
"we",
"demonstrated",
"that",
"phorbol",
"ester",
"treatment",
"of",
"human",
"peripheral",
"blood",
"monocytes",
"dramatically",
"inhibits",
"activation",
"of",
"IFN-alpha/B-stimulated",
"early",
"response",
"genes",
"but",
"by",
"a",
"mechanism",
"which",
"does",
"not",
"involve",
"abrogation",
"of",
"the",
"ISRE",
"binding",
"of",
"ISGF3gamma",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
7,
8,
8,
8,
0,
0,
0,
0,
1,
2,
2,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
0,
0,
9,
0
] |
5073 | [
"Phorbol",
"ester",
"treatment",
"of",
"monocytes",
"inhibited",
"IFN",
"alpha-stimulated",
"tyrosine",
"phosphorylation",
"of",
"the",
"transcription",
"factors",
"Stat1alpha",
",",
"Stat2",
",",
"and",
"Stat3",
"and",
"of",
"the",
"tyrosine",
"kinase",
"Tyk2",
"but",
"had",
"no",
"effect",
"on",
"IFN-gamma",
"activation",
"of",
"Stat1alpha",
"."
] | [
0,
0,
0,
0,
7,
0,
0,
0,
0,
0,
0,
0,
9,
10,
10,
0,
9,
0,
0,
9,
0,
0,
0,
9,
10,
10,
0,
0,
0,
0,
0,
9,
0,
0,
9,
0
] |
5074 | [
"IFNalpha-stimulated",
"tyrosine",
"phosphorylation",
"of",
"Jak1",
"and",
"the",
"alpha",
"subunit",
"of",
"the",
"IFN-alpha",
"receptor",
"were",
"unaffected",
"by",
"phorbol",
"12-myristate",
"13-acetate",
"(",
"PMA",
")",
"."
] | [
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
9,
10,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
5075 | [
"Moreover",
",",
"PMA",
"caused",
"the",
"dephosphorylation",
"of",
"Tyk2",
"but",
"not",
"of",
"Jak1",
",",
"which",
"was",
"activated",
"by",
"IFN",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
9,
0,
0,
0,
9,
0,
0,
0,
0,
0,
9,
0
] |
5076 | [
"Pretreatment",
"of",
"cells",
"with",
"vanadate",
"prevented",
"the",
"effects",
"of",
"PMA",
"with",
"regard",
"to",
"PMA-induced",
"Tyk2",
"dephosphorylation",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
0
] |
5077 | [
"These",
"observations",
"suggest",
"that",
"PMA",
"exerts",
"its",
"inhibitory",
"effects",
"by",
"activation",
"of",
"a",
"tyrosine",
"phosphatase",
"which",
"selectively",
"regulates",
"Tyk2",
"but",
"not",
"Jak1",
"activity",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
0,
0,
0,
9,
0,
0,
9,
0,
0
] |
5078 | [
"Transcriptional",
"regulation",
"of",
"the",
"interleukin-2",
"gene",
"in",
"normal",
"human",
"peripheral",
"blood",
"T",
"cells",
"."
] | [
0,
0,
0,
0,
1,
2,
0,
0,
7,
8,
8,
8,
8,
0
] |
5079 | [
"Convergence",
"of",
"costimulatory",
"signals",
"and",
"differences",
"from",
"transformed",
"T",
"cells",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
7,
8,
0
] |
5080 | [
"To",
"study",
"transcriptional",
"regulation",
"in",
"normal",
"human",
"T",
"cells",
",",
"we",
"have",
"optimized",
"conditions",
"for",
"transient",
"transfection",
"."
] | [
0,
0,
0,
0,
0,
0,
7,
8,
8,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
5081 | [
"Interleukin-2",
"(",
"IL-2",
")",
"promoter",
"-reporter",
"gene",
"behavior",
"closely",
"parallels",
"the",
"endogenous",
"gene",
"in",
"response",
"to",
"T",
"cell",
"receptor",
"and",
"costimulatory",
"signals",
"."
] | [
1,
2,
2,
2,
2,
2,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
10,
0,
0,
0,
0
] |
5082 | [
"As",
"assessed",
"with",
"mutagenized",
"promoters",
",",
"the",
"most",
"important",
"IL-2",
"cis-regulatory",
"elements",
"in",
"normal",
"T",
"cells",
"are",
"the",
"proximal",
"AP-1",
"site",
"and",
"the",
"NF-",
"kappaB",
"site",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
2,
0,
0,
7,
8,
0,
0,
0,
1,
2,
0,
0,
1,
2,
2,
0
] |
5083 | [
"Both",
"primary",
"activation",
",",
"with",
"phytohemagglutinin",
"or",
"antibodies",
"to",
"CD3",
",",
"and",
"costimulation",
",",
"provided",
"by",
"pairs",
"of",
"CD2",
"antibodies",
"or",
"B7-positive",
"(",
"B",
"cells",
")",
"or",
"B7-negative",
"(",
"endothelial",
")",
"accessory",
"cells",
",",
"are",
"mediated",
"through",
"the",
"same",
"cis-elements",
"."
] | [
0,
0,
0,
0,
0,
9,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
0,
0,
0,
7,
8,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
5084 | [
"Interestingly",
",",
"the",
"nuclear",
"factor",
"of",
"activated",
"T",
"cell",
"sites",
"are",
"much",
"less",
"important",
"in",
"normal",
"T",
"cells",
"than",
"in",
"Jurkat",
"T",
"cells",
"."
] | [
0,
0,
0,
1,
2,
2,
2,
2,
2,
2,
0,
0,
0,
0,
0,
0,
7,
8,
0,
0,
5,
6,
6,
0
] |
5085 | [
"We",
"conclude",
"that",
"IL-2",
"transcriptional",
"regulation",
"differs",
"in",
"tumor",
"cell",
"lines",
"compared",
"with",
"normal",
"T",
"cells",
"and",
"that",
"different",
"costimulatory",
"signals",
"converge",
"on",
"the",
"same",
"cis-elements",
"in",
"the",
"IL-2",
"promoter",
"."
] | [
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
7,
8,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
0
] |
5086 | [
"The",
"RAR-RXR",
"as",
"well",
"as",
"the",
"RXR-RXR",
"pathway",
"is",
"involved",
"in",
"signaling",
"growth",
"inhibition",
"of",
"human",
"CD34+",
"erythroid",
"progenitor",
"cells",
"."
] | [
0,
9,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
7,
8,
8,
8,
8,
0
] |
5087 | [
"Previous",
"studies",
"have",
"shown",
"that",
"retinoic",
"acid",
"(",
"RA",
")",
",",
"similar",
"to",
"tumor",
"necrosis",
"factor-alpha",
"(",
"TNF-alpha",
")",
",",
"can",
"act",
"as",
"a",
"bifunctional",
"regulator",
"of",
"the",
"growth",
"of",
"bone",
"marrow",
"progenitors",
",",
"in",
"that",
"it",
"can",
"stimulate",
"granulocyte-macrophage",
"colony-stimulating",
"factor",
"(",
"GM-CSF",
")",
"-",
"or",
"interleukin-3",
"(",
"IL-3",
")",
"-induced",
"GM",
"colony",
"formation",
",",
"but",
"potently",
"inhibit",
"G-CSF",
"-induced",
"growth",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
10,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
7,
8,
8,
0,
0,
0,
0,
0,
0,
9,
10,
10,
0,
9,
0,
0,
0,
9,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
0,
0
] |
5088 | [
"The",
"present",
"study",
",",
"using",
"highly",
"enriched",
"human",
"CD34+",
"as",
"well",
"as",
"Lin-",
"murine",
"bone",
"marrow",
"progenitor",
"cells",
",",
"demonstrates",
"a",
"potent",
"inhibitory",
"effect",
"of",
"9-cis-RA",
"on",
"burst-forming",
"unit-erythroid",
"(",
"BFU-E",
")",
"colony",
"formation",
"regardless",
"of",
"the",
"cytokine",
"stimulating",
"growth",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
7,
8,
8,
8,
8,
0,
0,
0,
0,
0,
0,
0,
0,
0,
7,
8,
0,
7,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
5089 | [
"Specifically",
",",
"9-cis-RA",
"potently",
"inhibited",
"the",
"growth",
"of",
"BFU-E",
"response",
"to",
"erythropoietin",
"(",
"Epo",
")",
"(",
"100",
"%",
")",
",",
"stem",
"cell",
"factor",
"(",
"SCF",
")",
"+",
"Epo",
"(",
"92",
"%",
")",
",",
"IL-3",
"+",
"Epo",
"(",
"97",
"%",
")",
",",
"IL-4",
"+",
"Epo",
"(",
"88",
"%",
")",
",",
"and",
"IL-9",
"+",
"Epo",
"(",
"100",
"%",
")",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
7,
0,
0,
9,
0,
9,
0,
0,
0,
0,
0,
0,
9,
10,
10,
0,
9,
0,
0,
9,
0,
0,
0,
0,
0,
9,
0,
9,
0,
0,
0,
0,
0,
9,
0,
9,
0,
0,
0,
0,
0,
0,
9,
0,
9,
0,
0,
0,
0,
0
] |
5090 | [
"Erythroid",
"colony",
"growth",
"was",
"also",
"inhibited",
"when",
"CD34+",
"progenitors",
"were",
"seeded",
"at",
"one",
"cell",
"per",
"well",
",",
"suggesting",
"a",
"direct",
"action",
"of",
"RA",
"."
] | [
7,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
5091 | [
"Using",
"synthetic",
"ligands",
"to",
"retinoic",
"acid",
"receptors",
"(",
"RARs",
")",
"and",
"retinoid",
"X",
"receptors",
"(",
"RXRs",
")",
"that",
"selectively",
"bind",
"and",
"activate",
"RAR-RXR",
"or",
"RXR-RXR",
"dimers",
",",
"respectively",
",",
"we",
"dissected",
"the",
"involvement",
"of",
"the",
"two",
"retinoid",
"response",
"pathways",
"in",
"the",
"regulation",
"of",
"normal",
"myeloid",
"and",
"erythroid",
"progenitor",
"cell",
"growth",
"."
] | [
0,
0,
0,
0,
9,
10,
10,
0,
9,
0,
0,
9,
10,
10,
0,
9,
0,
0,
0,
0,
0,
0,
9,
0,
9,
10,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
7,
8,
8,
0,
0
] |
5092 | [
"Transactivation",
"studies",
"showed",
"that",
"both",
"the",
"RAR",
"(",
"Ro",
"13-7410",
")",
"and",
"RXR",
"(",
"Ro",
"25-6603",
"and",
"Ro",
"25-7386",
")",
"ligands",
"were",
"highly",
"selective",
"at",
"100",
"nmol/L",
"."
] | [
0,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
5093 | [
"At",
"this",
"concentration",
",",
"Ro",
"13-7410",
"potently",
"inhibited",
"G-CSF",
"-stimulated",
"myeloid",
"as",
"well",
"as",
"SCF",
"+",
"Epo",
"-induced",
"erythroid",
"colony",
"growth",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
9,
0,
9,
0,
7,
0,
0,
0
] |
5094 | [
"At",
"the",
"same",
"concentration",
",",
"Ro",
"25-6603",
"and",
"Ro",
"25-7386",
"had",
"little",
"or",
"no",
"effect",
"on",
"G-CSF",
"-induced",
"colony",
"formation",
",",
"whereas",
"they",
"inhibited",
"75",
"%",
"and",
"53",
"%",
",",
"respectively",
",",
"of",
"SCF",
"+",
"Epo",
"-stimulated",
"BFU-E",
"colony",
"growth",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
9,
0,
7,
0,
0,
0
] |
5095 | [
"Thus",
",",
"the",
"RAR-RXR",
"response",
"pathway",
"can",
"signal",
"growth",
"inhibition",
"of",
"normal",
"bone",
"marrow",
"myeloid",
"and",
"erythroid",
"progenitor",
"cells",
"."
] | [
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
7,
8,
8,
0
] |
5096 | [
"In",
"addition",
",",
"we",
"demonstrate",
"a",
"unique",
"involvement",
"of",
"the",
"RXR-RXR",
"pathway",
"in",
"mediating",
"growth",
"inhibition",
"of",
"erythroid",
"but",
"not",
"myeloid",
"progenitor",
"cells",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
7,
0,
0,
7,
8,
8,
0
] |
5097 | [
"AM580",
",",
"a",
"stable",
"benzoic",
"derivative",
"of",
"retinoic",
"acid",
",",
"has",
"powerful",
"and",
"selective",
"cyto-differentiating",
"effects",
"on",
"acute",
"promyelocytic",
"leukemia",
"cells",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
5098 | [
"All-trans",
"retinoic",
"acid",
"(",
"ATRA",
")",
"is",
"successfully",
"used",
"in",
"the",
"cyto-differentiating",
"treatment",
"of",
"acute",
"promyelocytic",
"leukemia",
"(",
"APL",
")",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
5099 | [
"Paradoxically",
",",
"APL",
"cells",
"express",
"PML-RAR",
",",
"an",
"aberrant",
"form",
"of",
"the",
"retinoic",
"acid",
"receptor",
"type",
"alpha",
"(",
"RAR",
"alpha",
")",
"derived",
"from",
"the",
"leukemia-specific",
"t",
"(",
"15",
";",
"17",
")",
"chromosomal",
"translocation",
"."
] | [
0,
0,
7,
8,
0,
9,
0,
0,
0,
0,
0,
0,
9,
10,
10,
10,
10,
10,
10,
10,
10,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
5100 | [
"We",
"show",
"here",
"that",
"AM580",
",",
"a",
"stable",
"retinobenzoic",
"derivative",
"originally",
"synthesized",
"as",
"a",
"RAR",
"alpha",
"agonist",
",",
"is",
"a",
"powerful",
"inducer",
"of",
"granulocytic",
"maturation",
"in",
"NB4",
",",
"an",
"APL-derived",
"cell",
"line",
",",
"and",
"in",
"freshly",
"isolated",
"APL",
"blasts",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
5,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
7,
8,
0
] |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.