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5001
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5002
[ "This", "expression", "may", "in", "part", "reflect", "expression", "of", "A-myb", "by", "the", "normal", "germinal", "center", "B", "cells", "that", "are", "the", "normal", "counterpart", "of", "these", "transformed", "B", "cells", "." ]
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5003
[ "The", "data", "presented", "strongly", "support", "a", "role", "for", "this", "transcription", "factor", "in", "B-cell", "differentiation", "and", "perhaps", "in", "B-cell", "transformation", "in", "some", "neoplasias", "." ]
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5004
[ "Granulocyte-macrophage", "colony-stimulating", "factor", "stimulates", "JAK2", "signaling", "pathway", "and", "rapidly", "activates", "p93fes", ",", "STAT1", "p91", ",", "and", "STAT3", "p92", "in", "polymorphonuclear", "leukocytes", "." ]
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5005
[ "Granulocyte-macrophage", "colony-stimulating", "factor", "(", "GM-CSF", ")", ",", "supports", "proliferation", ",", "differentiation", ",", "and", "functional", "activation", "of", "hemopoietic", "cells", "by", "its", "interaction", "with", "a", "heterodimeric", "receptor", "." ]
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5006
[ "Although", "GM-CSF", "receptor", "is", "devoid", "of", "tyrosine", "kinase", "enzymatic", "activity", ",", "GM-CSF-induced", "peripheral", "blood", "polymorphonuclear", "leukocytes", "(", "PMN", ")", "functional", "activation", "is", "mediated", "by", "the", "phosphorylation", "of", "a", "large", "number", "of", "intracellular", "signaling", "molecules", "." ]
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5007
[ "We", "have", "previously", "shown", "that", "JAK2", "becomes", "tyrosine-phosphorylated", "in", "response", "to", "GM-CSF", "in", "PMN", "." ]
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5008
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5009
[ "Moreover", "GM-CSF", "was", "able", "to", "induce", "JAK2", "and", "p93fes", "catalytic", "activity", "." ]
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5010
[ "We", "also", "demonstrate", "that", "the", "association", "of", "the", "GM-CSF", "receptor", "beta", "common", "subunit", "with", "JAK2", "is", "ligand-dependent", "." ]
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5011
[ "Finally", "we", "demonstrate", "that", "GM-CSF", "induces", "a", "DNA-binding", "complex", "that", "contains", "both", "p91", "and", "p92", "." ]
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5012
[ "These", "results", "identify", "a", "new", "signal", "transduction", "pathway", "activated", "by", "GM-CSF", "and", "provide", "a", "mechanism", "for", "rapid", "activation", "of", "gene", "expression", "in", "GM-CSF-stimulated", "PMN", "." ]
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5013
[ "Epstein-Barr", "virus", "nuclear", "antigen", "2", "(", "EBNA2", ")", "-oestrogen", "receptor", "fusion", "proteins", "complement", "the", "EBNA2-deficient", "Epstein-Barr", "virus", "strain", "P3HR1", "in", "transformation", "of", "primary", "B", "cells", "but", "suppress", "growth", "of", "human", "B", "cell", "lymphoma", "lines", "." ]
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5014
[ "To", "develop", "a", "transformation", "system", "with", "a", "conditional", "Epstein-Barr", "virus", "nuclear", "antigen", "2", "(", "EBNA2", ")", "gene", ",", "we", "fused", "the", "hormone", "binding", "domain", "of", "the", "oestrogen", "receptor", "to", "the", "N", "or", "C", "terminus", "of", "EBNA2", "." ]
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5015
[ "In", "promoter", "transactivation", "as", "well", "as", "primary", "B", "cell", "transformation", "assays", "these", "chimeric", "EBNA2", "proteins", "are", "able", "to", "substitute", "for", "wild-type", "EBNA2", "in", "the", "presence", "of", "oestrogen", "." ]
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5016
[ "Here", "we", "provide", "evidence", "that", "this", "transformation", "is", "the", "result", "of", "double", "infection", "of", "a", "cell", "with", "two", "virions", ",", "the", "P3HR1", "virus", "genome", "and", "a", "mini-EBV", "plasmid", "carrying", "the", "chimeric", "EBNA2", "gene", "." ]
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5017
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5018
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5019
[ "We", "propose", "that", "growth", "inhibition", "of", "established", "B", "cell", "lymphoma", "lines", "is", "a", "novel", "function", "of", "EBNA2", "which", "has", "not", "been", "detected", "in", "the", "absence", "of", "an", "inducible", "system", "." ]
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5020
[ "It", "remains", "open", "whether", "the", "growth", "retarding", "property", "of", "the", "EBNA2-oestrogen", "receptor", "fusion", "protein", "in", "B", "cell", "lymphoma", "lines", "is", "due", "to", "unphysiologically", "high", "expression", "of", "the", "chimeric", "protein", "or", "to", "interference", "with", "a", "cellular", "programme", "driving", "proliferation", "in", "these", "cell", "lines", "." ]
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5021
[ "Tissue-specific", "activity", "of", "the", "gammac", "chain", "gene", "promoter", "depends", "upon", "an", "Ets", "binding", "site", "and", "is", "regulated", "by", "GA-binding", "protein", "." ]
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5022
[ "The", "gammac", "chain", "is", "a", "subunit", "of", "multiple", "cytokine", "receptors", "(", "interleukin", "(", "IL", ")", "-2", ",", "IL-4", ",", "IL-7", ",", "IL-9", ",", "and", "IL-15", ")", ",", "the", "expression", "of", "which", "is", "restricted", "to", "hematopoietic", "lineages", "." ]
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5023
[ "A", "defect", "in", "gammac", "leads", "to", "the", "X-linked", "severe", "combined", "immunodeficiency", "characterized", "by", "a", "block", "in", "T", "cell", "differentiation", "." ]
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5024
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5025
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5026
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5027
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5028
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5029
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5030
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5031
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5032
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5033
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5034
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5035
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5036
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5037
[ "Antibodies", "to", "Stat6", "detected", "a", "unique", "band", "in", "macaque", "cell", "lysates", "." ]
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5038
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5039
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5040
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5041
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5042
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5043
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5044
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5045
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5047
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5048
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5050
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5051
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5052
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5053
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5054
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