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4901
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4902
[ "Interferon-gamma", "modulates", "the", "lipopolysaccharide-induced", "expression", "of", "AP-1", "and", "NF-kappa", "B", "at", "the", "mRNA", "and", "protein", "level", "in", "human", "monocytes", "." ]
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4903
[ "Interferon-gamma", "(", "IFN-gamma", ")", "modulates", "the", "expression", "of", "several", "cytokines", "by", "human", "monocytes", "at", "the", "transcriptional", "level", "." ]
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4904
[ "In", "view", "of", "these", "findings", ",", "we", "analyzed", "the", "effects", "of", "IFN-gamma", "on", "the", "expression", "of", "different", "transcription", "factors", "in", "activated", "human", "monocytes", "." ]
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4905
[ "Priming", "of", "human", "monocytes", "with", "IFN-gamma", "resulted", "in", "the", "down", "regulation", "of", "c-fos", "and", "c-jun", "mRNA", "in", "response", "to", "stimulation", "with", "lipopolysaccharide", "(", "LPS", ")", "compared", "to", "the", "effects", "of", "LPS", "alone", "." ]
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4906
[ "Not", "only", "was", "this", "effect", "observed", "at", "the", "mRNA", "level", ",", "but", "activator", "protein-1", "(", "AP-1", ")", "DNA", "binding", "capacity", "was", "affected", "as", "well", ",", "A", "strong", "reduction", "was", "observed", "in", "the", "LPS-induced", "DNA-binding", "activity", "of", "AP-1", "in", "the", "presence", "of", "IFN-gamma", "." ]
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4907
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4908
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4909
[ "Priming", "with", "IFN-gamma", "followed", "by", "LPS", "stimulation", "resulted", "in", "a", "further", "increase", "in", "the", "expression", "of", "p65", "mRNA", "." ]
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4910
[ "This", "was", "due", "to", "an", "increase", "in", "the", "half-life", "of", "p65", "mRNA", "(", "75", "vs", "150", "minutes", ")", "." ]
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4911
[ "Electrophoretic", "mobility", "shift", "assays", "(", "EMSAs", ")", "demonstrated", "that", "unstimulated", "monocytes", "predominantly", "expressed", "p50", "NF-kappa", "B", "." ]
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4912
[ "Stimulation", "with", "LPS", "or", "IFN-gamma", "resulted", "in", "the", "expression", "of", "p50", "and", "p65", "subunits", ",", "while", "the", "combination", "of", "IFN-gamma", "plus", "LPS", "caused", "a", "further", "increase", "in", "the", "expression", "of", "NF-kappa", "B", "." ]
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4913
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4914
[ "However", ",", "the", "combined", "stimulation", "did", "not", "result", "in", "enhanced", "p50", "and", "p65", "protein", "expression", "." ]
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4915
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4916
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4917
[ "HIV-1", "tat", "induces", "the", "expression", "of", "a", "new", "hematopoietic", "cell-specific", "transcription", "factor", "and", "downregulates", "MIP-1", "alpha", "gene", "expression", "in", "activated", "T-cells", "." ]
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4918
[ "MIP-1", "alpha", "is", "a", "secreted", "chemokine", "which", "can", "inhibit", "hematopoietic", "stem", "cells", "and", "modulate", "inflammatory", "responses", "." ]
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4919
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4920
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4921
[ "It", "is", "also", "expressed", "in", "transformed", "B-cells", "." ]
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4922
[ "We", "have", "previously", "identified", "a", "new", "transcription", "factor", "family", "(", "the", "MNP", "family", ")", "whose", "expression", "is", "crucial", "for", "the", "induction", "of", "MIP-1", "alpha", "transcription", "during", "cellular", "activation", "and", "in", "transformed", "B", "cells", "." ]
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4923
[ "Monocytes", "and", "transformed", "B-cells", "normally", "express", "MNP-1", "strongly", "and", "MNP-2", "weakly", ",", "while", "T-cells", "strongly", "express", "only", "MNP-2", "." ]
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4924
[ "Recently", ",", "we", "reported", "that", "HIV-1", "tat", "downregulates", "MIP-1", "alpha", "expression", "in", "Jurkat", "T-cells", "." ]
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4925
[ "In", "this", "report", "we", "show", "induction", "of", "MNP-1", "in", "Jurkat", "T-cells", "expressing", "HIV-1", "tat", "." ]
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4926
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4927
[ "We", "propose", "that", "HIV-1", "tat", "may", "inhibit", "MIP-1", "alpha", "expression", "by", "inducing", "MNP-1", "expression", "in", "T-cells", ",", "probably", "by", "either", "competing", "with", "MNP-2", "for", "binding", "to", "the", "MIP-1", "alpha", "promoter", "or", "by", "sequestering", "it", "into", "inactive", "forms", "." ]
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4928
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4929
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4930
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4931
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4932
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4933
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4934
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4935
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4936
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4937
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4938
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4939
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4940
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4941
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4942
[ "A", "single", "EGR1", "binding", "motif", "is", "demonstrated", "at", "bp", "-301", "of", "the", "human", "CD44", "promoter", "." ]
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4943
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4944
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4945
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4946
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4947
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4948
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4949
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4950
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4951
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4952
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4953
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4954
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4955
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4956
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4957
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4958
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4977
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