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4801
[ "As", "neutrophils", "occupy", "approximately", "92", "%", "of", "the", "cells", "in", "this", "fraction", ",", "the", "cells", "expressing", "p45", "is", "most", "likely", "to", "be", "neutrophils", "." ]
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4802
[ "p45", "mRNA", "is", "also", "expressed", "in", "HL-60", "promyelocytes", ",", "albeit", "the", "expression", "level", "is", "much", "lower", "than", "that", "of", "the", "granulocyte", "fraction", "." ]
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4803
[ "HL-60", "cells", "were", "found", "to", "express", "mafK", "mRNA", ",", "indicating", "the", "presence", "of", "genuine", "NF-E2", "complex", "in", "the", "cells", "." ]
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4804
[ "Although", "p45", "mRNA", "is", "transcribed", "from", "two", "different", "promoters", ",", "aNF-E2", "promoter", "and", "fNF-E2", "promoter", ",", "in", "erythroid", "and", "megakaryocytic", "lineage", "cells", ",", "p45", "mRNA", "is", "transcribed", "only", "from", "aNF-E2", "promoter", "." ]
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4805
[ "The", "expression", "of", "p45", "megakaryocytic", "lineage", "cells", ",", "p45", "mRNA", "is", "transcribed", "only", "from", "aNF-E2", "promoter", "." ]
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4806
[ "The", "expression", "of", "p45", "mRNA", "in", "the", "neutrophils", "declined", "rapidly", "after", "transfer", "of", "the", "cells", "to", "in", "vitro", "culture", "and", "G-CSF", "could", "not", "sustain", "the", "expression", "from", "the", "down-regulation", ",", "suggesting", "the", "E2", "may", "also", "participate", "in", "the", "regulation", "of", "neutrophil-specific", "gene", "expression", "." ]
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4807
[ "Expression", "of", "c-fos", "and", "c-jun", "proteins", "and", "AP-1", "binding", "activity", "during", "cell", "cycle", "progression", "of", "HL60", "cells", "and", "phytohemagglutinin-stimulated", "lymphocytes", "." ]
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4808
[ "The", "protein", "products", "of", "the", "c-fos", "(", "p62c-fos", ")", "and", "c-jun", "(", "p39c-jun", ")", "genes", "are", "members", "of", "the", "AP-1", "transcription", "factor", "family", "and", "are", "thought", "to", "play", "important", "roles", "in", "the", "regulation", "of", "gene", "expression", "during", "the", "cell", "cycle", "." ]
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4809
[ "Most", "studies", "on", "the", "expression", "of", "these", "proteins", "in", "relation", "to", "the", "cell", "cycle", "have", "been", "performed", "at", "the", "mRNA", "level", ",", "and", "therefore", "do", "not", "give", "direct", "information", "about", "the", "presence", "of", "the", "proteins", "during", "the", "cell", "cycle", "." ]
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4810
[ "We", "have", "used", "Western", "blotting", "to", "investigate", "the", "presence", "of", "these", "proteins", "during", "the", "cell", "cycles", "of", "two", "different", "cellular", "systems", ":", "a", "continuously", "growing", "myeloid", "leukemic", "cell", "line", ",", "HL60", ",", "and", "normal", "cells", "stimulated", "into", "cycle", ",", "phyto-", "hemagglutinin", "(", "PHA", ")", "-stimulated", "normal", "human", "peripheral", "blood", "lymphocytes", "(", "PBL", ")", "." ]
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4811
[ "The", "binding", "activity", "of", "transcription", "factor", "AP-1", ",", "which", "consists", "of", "dimers", "of", "Fos", "and", "Jun", "family", "proteins", ",", "was", "also", "studied", "using", "a", "gel", "shift", "assay", "." ]
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4812
[ "We", "found", "nuclear", "p62c-fos", ",", "p39c-jun", ",", "and", "AP-1", "binding", "activity", "throughout", "the", "cell", "cycle", "both", "in", "HL60", "cells", "and", "in", "PHA-stimulated", "PBL", ",", "and", "we", "postulate", "that", "these", "proteins", "are", "required", "throughout", "the", "cell", "cycle", "and", "not", "transiently", "in", "the", "G0", "to", "G1", "transition", "as", "previous", "mRNA", "studies", "have", "indicated", "." ]
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4813
[ "We", "demonstrated", "an", "uncoupling", "of", "AP-1", "binding", "activity", "from", "p62c-fos", ",", "and", "p39c-jun", "AP-1", "activity", "was", "expressed", "more", "strongly", "in", "the", "G1-", "and", "G2/M-phase", "enriched", "samples", "than", "in", "the", "S-phase", "enriched", "samples", "of", "HL60", "cells", ",", "while", "levels", "of", "nuclear", "p62c-fos", "and", "p39c-jun", "were", "constant", "." ]
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4814
[ "Nuclei", "of", "unstimulated", "PBL", "from", "different", "donors", "expressed", "p62c-fos", "and", "p39c-jun", ",", "but", "AP-1", "was", "not", "detected", "in", "the", "majority", "of", "samples", "." ]
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4815
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4816
[ "We", "also", "observed", "that", "cytoplasmic", "p62c-fos", "and", "p39c-jun", "were", "present", "in", "HL60", "cells", "and", "PHA-stimulated", "PBL", "." ]
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4817
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4818
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4819
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4820
[ "Our", "previous", "studies", "(", "Chen", ",", "H.M.", ",", "Ray-Gallet", ",", "D.", ",", "Zhang", ",", "P.", ",", "Hetherington", ",", "C.J.", ",", "Gonzalez", ",", "D.A.", ",", "Zhang", ",", "D.-E.", ",", "Moreau-Gachelin", ",", "F.", ",", "and", "Tenen", ",", "D.G.", "(", "1995", ")", "Oncogene", "11", ",", "1549-1560", ")", "demonstrate", "that", "the", "PU.1", "promoter", "directs", "cell", "type-specific", "reporter", "gene", "expression", "in", "myeloid", "cell", "lines", ",", "and", "that", "PU.1", "activates", "its", "own", "promoter", "in", "an", "autoregulatory", "loop", "." ]
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4821
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4822
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4823
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4824
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4825
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4826
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4827
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4828
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4830
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4831
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4832
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4833
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4834
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4835
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4836
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4837
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4838
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4839
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4840
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4841
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4842
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4843
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4845
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4847
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4848
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4849
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4850
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4851
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4853
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4854
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4860
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4866
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4869
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4871
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4872
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4874
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4875
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4876
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4877
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4878
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4880
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4889
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4894
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