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3601
[ "Activated", "viral", "gene", "expression", "associated", "with", "phenotypic", "conversion", "of", "group", "I", "cell", "lines", "in", "to", "group", "II", "or", "III", "restores", "the", "Egr-1", "gene", "expression", "." ]
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3602
[ "Several", "forms", "of", "EGR-1", "protein", "are", "found", "within", "the", "different", "groups", "of", "cell", "lines", ",", "and", "the", "binding", "activity", "to", "DNA", "consensus", "sequences", "was", "investigated", "." ]
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3603
[ "Finally", ",", "time", "course", "analysis", "of", "Egr-1", "expression", "during", "the", "early", "steps", "of", "EBV", "infection", "in", "vitro", "demonstrated", "that", "Egr-1", "is", "upregulated", "within", "minutes", "from", "the", "initial", "interaction", "with", "the", "B", "lymphocyte", "." ]
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3604
[ "Expression", "of", "erythroid-specific", "genes", "in", "megakaryoblastic", "disorders", "." ]
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3605
[ "Currently", "available", "data", "indicate", "that", "erythroid", "and", "megakaryocytic", "differentiation", "pathways", "are", "closely", "related", "to", "each", "other", ",", "and", "there", "may", "exist", "progenitor", "cells", "common", "to", "those", "two", "lineages", "may", "exist", "." ]
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3606
[ "Acute", "megakaryoblastic", "leukemia", "(", "AML-M7", ")", "and", "transient", "myeloproliferative", "disorder", "in", "Down", "'s", "syndrome", "(", "TMD", ")", "are", "characterized", "by", "rapid", "growth", "of", "abnormal", "blast", "cells", "which", "express", "megakaryocytic", "markers", "." ]
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3607
[ "These", "blast", "cells", "express", "lineage-specific", "transcription", "factors", "such", "as", "GATA-1", "common", "to", "these", "lineages", "and", "frequently", "express", "erythroid-specific", "mRNAs", "such", "as", "gamma-globin", "and", "erythroid", "delta-aminolevulinate", "synthase", "(", "ALAS-E", ")", ",", "indicating", "that", "most", "of", "the", "blasts", "in", "M7", "and", "TMD", "cases", "have", "erythroid", "and", "megakaryocytic", "phenotypes", "." ]
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3608
[ "These", "results", "suggest", "that", "blasts", "in", "M7", "and", "TMD", "may", "correspond", "to", "progenitors", "of", "both", "erythroid", "and", "megakaryocytic", "lineages", "." ]
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3609
[ "Stat3", "recruitment", "by", "two", "distinct", "ligand-induced", ",", "tyrosine-phosphorylated", "docking", "sites", "in", "the", "interleukin-10", "receptor", "intracellular", "domain", "." ]
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3610
[ "Recent", "work", "has", "shown", "that", "IL-10", "induces", "activation", "of", "the", "JAK", "-STAT", "signaling", "pathway", "." ]
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3611
[ "To", "define", "the", "mechanism", "underlying", "signal", "transducer", "and", "activator", "of", "transcription", "(", "STAT", ")", "protein", "recruitment", "to", "the", "interleukin", "10", "(", "IL-10", ")", "receptor", ",", "the", "STAT", "proteins", "activated", "by", "IL-10", "in", "different", "cell", "populations", "were", "first", "defined", "using", "electrophoretic", "mobility", "shift", "assays", "." ]
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3612
[ "In", "all", "cells", "tested", ",", "IL-10", "activated", "Stat1", "and", "Stat3", "and", "induced", "the", "formation", "of", "three", "distinct", "DNA", "binding", "complexes", "that", "contained", "different", "combinations", "of", "these", "two", "transcription", "factors", "." ]
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3613
[ "IL-10", "also", "activated", "Stat5", "in", "Ba/F3", "cells", "that", "stably", "expressed", "the", "murine", "IL-10", "receptor", "." ]
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3614
[ "Using", "a", "structure-function", "mutagenesis", "approach", ",", "two", "tyrosine", "residues", "(", "Tyr427", "and", "Tyr477", ")", "in", "the", "intracellular", "domain", "of", "the", "murine", "IL-10", "receptor", "were", "found", "to", "be", "redundantly", "required", "for", "receptor", "function", "and", "for", "activation", "of", "Stat3", "but", "not", "for", "Stat1", "or", "Stat5", "." ]
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3615
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3616
[ "In", "contrast", ",", "tyrosine-phosphorylated", "peptides", "containing", "Tyr374", "or", "Tyr396", "did", "not", "interact", "with", "Stat3", "or", "block", "Stat3", "activation", "." ]
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3617
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3618
[ "This", "study", "thus", "supports", "the", "concept", "that", "utilization", "of", "distinct", "STAT", "proteins", "by", "different", "cytokine", "receptors", "is", "dependent", "on", "the", "expression", "of", "particular", "ligand-activatable", ",", "tyrosine-containing", "STAT", "docking", "sites", "in", "receptor", "intracellular", "domains", "." ]
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3619
[ "Silencing", "of", "human", "fetal", "globin", "expression", "is", "impaired", "in", "the", "absence", "of", "the", "adult", "beta-globin", "gene", "activator", "protein", "EKLF", "." ]
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3620
[ "Globin", "genes", "are", "subject", "to", "tissue-specific", "and", "developmental", "stage-specific", "regulation", "." ]
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3621
[ "A", "switch", "from", "human", "fetal", "(", "gamma", ")", "-to", "adult", "(", "beta", ")", "-globin", "expression", "occurs", "within", "erythroid", "precursor", "cells", "of", "the", "adult", "lineage", "." ]
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3622
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3623
[ "To", "examine", "the", "role", "of", "EKLF", "in", "the", "developmental", "regulation", "of", "the", "human", "gamma-globin", "gene", "we", "interbred", "EKLF", "heterozygotes", "(", "+/-", ")", "with", "mice", "harboring", "a", "human", "beta-globin", "yeast", "artificial", "chromosome", "transgene", "." ]
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3624
[ "We", "find", "that", "in", "the", "absence", "of", "EKLF", ",", "while", "human", "beta-globin", "expression", "is", "dramatically", "reduced", ",", "gamma-globin", "transcripts", "are", "elevated", "approximately", "5-fold", "." ]
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3625
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3626
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3627
[ "Stimulation", "of", "human", "peripheral", "blood", "mononuclear", "cells", "by", "zinc", "and", "related", "cations", "." ]
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3628
[ "Zinc", "is", "an", "important", "trace", "element", "for", "immune", "function", "." ]
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3629
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3630
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3631
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3632
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3633
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3634
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3635
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3636
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3637
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3638
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3639
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3640
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3641
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3642
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3643
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3644
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3645
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3646
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3647
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3648
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3649
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3650
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3651
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3652
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3658
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3659
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3660
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3661
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3662
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3663
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3665
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3666
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3667
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3668
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3669
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3670
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3671
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3673
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3674
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3675
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3676
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3677
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3678
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3679
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3680
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3681
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3682
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3683
[ "Productive", "human", "immunodeficiency", "virus", "type", "1", "(", "HIV-1", ")", "infection", "causes", "sustained", "NF-kappaB", "DNA-binding", "activity", "in", "chronically", "infected", "monocytic", "cells", "." ]
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3684
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3685
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3686
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3687
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3688
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3690
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3691
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3692
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3693
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3695
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3696
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3697
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3699
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