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3701
[ "Retinoic", "acid", "activates", "interferon", "regulatory", "factor-1", "gene", "expression", "in", "myeloid", "cells", "." ]
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3702
[ "All-trans-retinoic", "acid", "(", "ATRA", ")", "is", "the", "drug", "of", "choice", "in", "the", "treatment", "of", "acute", "promyelocytic", "leukemia", "(", "APL", ")", "." ]
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3703
[ "ATRA", "induces", "both", "in", "vitro", "and", "in", "vivo", "differentiation", "of", "APL", "cells", "into", "mature", "granulocytes", "." ]
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3704
[ "However", ",", "the", "molecular", "mechanisms", "involved", "in", "ATRA-dependent", "growth", "inhibition", "and", "cellular", "differentiation", "are", "not", "presently", "understood", "." ]
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3705
[ "The", "NB4", "cell", "line", ",", "which", "is", "derived", "from", "the", "bone", "marrow", "of", "a", "patient", "with", "APL", "during", "relapse", ",", "can", "be", "used", "as", "a", "model", "system", "to", "study", "the", "growth", "and", "differentiation", "of", "APL", "cells", "." ]
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3706
[ "Because", "interferon", "(", "IFN", ")", "regulatory", "factors", "(", "IRF-1", "and", "IRF-2", ")", "and", "other", "IFN-inducible", "gene", "products", "regulate", "cell", "growth", ",", "we", "analyzed", "the", "effects", "of", "ATRA", "on", "the", "expression", "of", "these", "genes", "." ]
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3707
[ "We", "show", "that", "ATRA", "directly", "activates", "IRF-1", "gene", "expression", ",", "followed", "by", "activation", "of", "IRF-2", "and", "2'-5", "'", "oligoadenylate", "synthetase", "(", "OAS", ")", "gene", "expression", "with", "slower", "kinetics", "." ]
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3708
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3709
[ "A", "more", "than", "additive", "increase", "in", "IRF-1", "gene", "expression", "was", "seen", "with", "ATRA", "and", "IFN-gamma", "in", "NB4", "cells", "." ]
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3710
[ "ATRA", "did", "not", "activate", "nuclear", "factor", "kappa", "B", "or", "signal", "transducer", "and", "activator", "of", "transcription", "(", "STAT", ")", "activation", "pathways", ",", "suggesting", "that", "an", "alternate", "mechanism", "is", "involved", "in", "IRF-1", "gene", "activation", "." ]
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3711
[ "The", "ATRA-induced", "expression", "of", "IRF-1", ",", "an", "activator", "of", "transcription", "and", "repressor", "of", "transformation", ",", "may", "be", "one", "of", "the", "molecular", "mechanisms", "of", "ATRA-induced", "growth", "inhibition", ",", "and", "the", "basis", "for", "the", "synergistic", "actions", "of", "ATRA", "and", "IFNs", "in", "myeloid", "leukemia", "cells", "." ]
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3712
[ "Recombinant", "NFAT1", "(", "NFATp", ")", "is", "regulated", "by", "calcineurin", "in", "T", "cells", "and", "mediates", "transcription", "of", "several", "cytokine", "genes", "." ]
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3713
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3714
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3715
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3716
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3717
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3718
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3719
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3720
[ "Human", "TAFII", "105", "is", "a", "cell", "type-specific", "TFIID", "subunit", "related", "to", "hTAFII130", "." ]
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3721
[ "We", "previously", "characterized", "Drosophila", "and", "human", "TAF", "subunits", "that", "make", "up", "the", "core", "TFIID", "complex", "found", "in", "all", "cells", "." ]
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3722
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3723
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3724
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3725
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3726
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3727
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3728
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3729
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3730
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3731
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3733
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3734
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3735
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3736
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3737
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3738
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3740
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3741
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3744
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3745
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3746
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