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6,000
(Note: We are aware of the method [3] which is another variant of 2D FCN and achieved excellent performance on the neuron dataset.
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method
6,001
Randomized controlled trials conducted in a range of surgical settings over the last 25 years have clearly demonstrated that enoxaparin is associated with lower rates of VTE than placebo or elastic compression, without compromising patient safety [5–9].
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background
6,002
Evaluating diverse predictions Where only a single ground truth answer exists, the k-best oracle [11, 23] is a suitable scheme for evaluating diverse predictions.
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background
6,003
In-between methods can be subdivided into linear approximations [12,24] and quadratic interpolation methods [22,23,25–27] based on the degree of the polynomial approximation employed.
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background
6,004
bacterial species can drive major changes in the gut microbiota and, thus, influence the metabolic profile (Marcobal et al., 2013).
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background
6,005
Xu et al [42] observed TF occupancy across the blocus of proerythroblast derived from fetal liver and adult stem cells.
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background
6,006
The well-known tumor suppressor p53 is a transcriptional master regulator that regulates the expression of genes associated with a wide range of functions, including cell-cycle arrest, apoptosis, and senescence in response to genotoxic andnongenotoxic stresses that challenge cellular genomic integrity (1).
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6,007
CBP adds to its input layer an extra node having an input of the sum of the squared input components [1, 2].
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method
6,008
reported that low miR-99a expression in hepatocellular carcinoma (HCC) tissues was associated with worse prognosis in HCC patients [10].
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background
6,009
Between 1987 and 1998 the prevalence of FOBT screening increased slightly, while screening rates for endoscopies doubled in the US [35].
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background
6,010
It should be noted that a WURS cut-off score of 46 or higher can discriminate individuals with a history of childhood attention-deficit/ hyperactivity disorder (Kafka & Prentky, 1998; Roy-Byrne et al., 1997; Ward et al., 1993; Wender, 1995).
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background
6,011
This would be in accordance with data showing that the PVN is important for dietary preference for carbohydrates and lesions to the PVN result in increased preference for high fat diets (Aravich and Sclafani, 1983; Leibowitz, 1988; Hoebel et al., 1989).
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result
6,012
Nonetheless, marketed EGFR antibodies have limited potential for development as ADCs because their significant binding to normal tissue causes on-target toxicity (9).
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6,013
An interdisciplinary approach has been advocated for in a broad range of healthcare fields, including primary care [1, 2], developmental disability assessment [3], com-
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6,014
In addition, G4 DNA could form at telomeres either at the 3’ single strand G-rich overhang (22) or by molecular crowding of duplex DNA (23).
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6,015
In Section 2, we present an experiment by Abeler et al. (2010) that analyzes the relative importance of two conflicting fairness principles—wage equality and horizontal equity. In particular, Abeler et al. study whether equal wages are considered fair and look at potentially detrimental consequences of equal wages on performance. In Section 3, we turn to a second question that becomes important when principals interact with more than one agent, namely, whether the principal can observe agents’ individual performance or only the outcomes of the group of agents as a whole. We present a recent study by Kleine and Kube (2010) that addresses the question whether reporting (subjective) performance measures can enhance the efficiency of interaction in work groups. Next, we discuss a study by Schneider and Kube (2006) that analyzes how differences in social proximity affect gift exchange in multi-worker firms.
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6,016
Our findings, in accordance with Smith et al. (2004), demonstrate a neuropsychological dissociation between endogenous and exogenous validity effects.
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result
6,017
(2016) demonstrated that blocking MST1/2 kinase activities with a newly identified compound, 4-((5,10-dimethyl-6-oxo-6,10-dihydro-5H-pyrimido [5,4-b]thieno[3,2-e][1,4]diazepin-2-l)amino)benzenesulfonamide (XMU-MP-1), has benefits for intestinal and liver repair and regeneration in mice (Fan et al., 2016).
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background
6,018
1996) and then to the effector enzyme, namely phospholipase C-b 2 (PLC-b 2) (Adler et al. 2000).
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background
6,019
Another approach to scaling the PK parameters was a theoretical approach that fixed the allometric exponent to its theoretical values [14].
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background
6,020
Previous research using the WSAP suggests that interpretation biases based on reaction time measures may be different for socially anxious undergraduates than for individuals with SAD (Amir et al. 2012).
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method
6,021
LDL CHD There is strong evidence that genetic variants that increase LDL also proportionately increase risk of CHD (46).
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background
6,022
This method was recently used to estimate cancer incidence in France and China [22, 25] and is frequently used by GLOBOCAN [26].
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method
6,023
Rats were killed after 2.5 min, which was the time found to produce significant AA release mediated by PLA2 activity after in vivo LTP induction (Clements et al., 1991).
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method
6,024
Geographical locales where gonorrhoea incidence was much higher than surrounding areas have been identified as possible ‘core’ populations (Rothenberg 1983; Bernstein et al. 2004).
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6,025
…studies found similar results when comparing resisted sprint training with elastic bands (Myer, Ford, Brent, Divine, & Hewett, 2007), weighted-sled (Spinks et al., 2007; West et al., 2012), weighted-vest (Clark et al., 2010; Rey, Padron-Cabo, & Fernandez-Penedo, 2016) with unresisted training on…
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result
6,026
BM3D BRIS- CPBD JNB LPC S3 BIQI Metri- Ours QUE[17] [19] [11] [14] [26] [18] cQ[30]
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background
6,027
Protein extraction, western blots and immunoprecipitations were performed as previously described (Pentimalli et al., 2008).
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method
6,028
…(Trueman et al., 1996); two NADH-NR, NR1 and NR2 (Long et al., 1992); nitrite reductase, NiR (Lahners et al., 1988); glutamate dehydrogenase, GDH1 (Sakakibara et al., 1995); four cytosolic GS, gln1, gln2, gln3, and gln4, plastidic GS, gln5 (Sakakibara et al., 1992a); and asparagine synthetase…
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background
6,029
During phase (1), it looks for hidden correlations among the attribute values and the class attribute in the training data set and generates them as ‘‘Class Association Rule’’ (CARs) in ‘‘If-Then’’ format (Thabtah et al., 2004).
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6,030
Many investigations have focused on the evaluation of genotoxicity of pesticides in occupational or environmental settings using different methods (2-12).
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method
6,031
Post-mortem studies have shown that cholinergic markers depletion strongly correlates with symptoms severity in AD (Dournaud et al., 1995; Prohovnik et al., 2006). ing Laboratory (TNL), McGill alth University Institute, 6875 rdun), QC, Canada H4H 1R3.
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6,032
It is likely to be responsible for generating the proton gradient in these organelles detected with MitoLight and Rhodamine 123 staining (Zierdt et al. 1988; Nasirudeen and Tan 2004) and MitoTracker (Hamblin et al. 2008; Stechmann et al. 2008).
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6,033
This is closely related to skin pigmentation as melanin has been shown to have a protective function for UV-induced melanoma and Caucasian populations show low levels of melanogenesis (Lens and Dawes, 2004; Hu et al., 2008; Jemal et al., 2010).
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6,034
Stimuli surfaces were irregular-shaped wooden boards manually placed on a metal slope-presentation device that allowed the experimenter to quickly and accurately set the wooden board to a predetermined angle (see Durgin, Li & Hajnal, 2010; Li and Durgin, 2009).
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6,035
These results are consistent with several studies that have suggested that miR-199a-3p is a potential tumor suppressor (24-27).
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result
6,036
The answer to this question is currently unknown, but experimental evidence so far suggests that non-motile mutants are at a severe disadvantage for establishing and maintaining interactions with these hosts (Black et al., 1988; Nachamkin et al., 1993; Wassenaar et al., 1993; Hendrixson and DiRita, 2004; Wösten et al., 2004).
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6,037
The importance of these techniques has led to a recent and intensive effort to develop and understand mathematical models for use in analysis of cell proliferation data [6, 12].
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6,038
A major drawback with NIFAS was that the applet only showed one simultaneous tree, but in order to analyze the evolution of different domains it is essential to compare their trees visually.
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method
6,039
Intermediate-conductance calcium-activated potassium channels (IK) enhance glioma cell migration induced by chemokines such as CXCL12 (74).
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background
6,040
EOs have proven effective in plant protection against plant chewing and sucking insect pests, as well as flies that oviposit in fruit [4].
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6,041
…gametophytes and sporophytes, we conducted a preliminary analysis with all Glomus sequences from Botrychium (Ophioglossaceae; Kovács et al. 2007; Winther and Friedman 2007), Lycopodiaceae (Winther and Friedman 2008) and Psilotum nudum (Psilotaceae; Winther and Friedman 2009) reported in…
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method
6,042
Moreover, the damp effect introduced by the back-plate will cause acoustic impedance, and to decrease the sensitivity of microphones subsequently [8-9].
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6,043
Recently, analyses of archived African desert dust samples collected between 1812 and 1838 by colleagues of Charles Darwin demonstrated concentrations of bacteria and fungi of 104e105 CFU g 1 (Gorbushina et al., 2007).
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6,044
The Hill coefficient values (“n”) were also consistent to those of the E. coli expressed P450 3A37 (Rawal et al., 2010b).
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result
6,045
(GC) [23], Seeded Region Growing (SRG) [24], Random Walker (RW) [18], Distance Regularized Level Set (DRLSE) [25], and Laplacian Coordinates (LAP) [26].
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6,046
One of the main problems in distributed systems is the deadlock problem [15].
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background
6,047
Although we found manual dissection of BG01 was successful, we adapted this line to trypsin-passaging on feeders and on Matrigel to facilitate comparison with an independently-derived line, HUES-7 (Cowan et al., 2004).
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result
6,048
The saccadic movement can be made by asking the client during the examination (Kuicken et al., 2001-2002; Parker et al., 2009).
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6,049
Symptoms of pain and tenderness have been common complaints in the majority of cases resulting from melorheostosis of the hand, and although there are many theories regarding the etiology of pain, the cause of pain associated with is not known [3].
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6,050
Since cryptographic systems on medical devices are susceptible to differential power analysis and fault analysis attacks [29–40], it is critical to analyze the security of Rainbow on hardware.
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background
6,051
To find novel genes in the FHV-1 genome ab initio, and as a second approach to verify the annotation, the sequence was submitted to GeneMarkS (Besemer et al., 2001).
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6,052
, 2015), plant nursery runoff (Huett et al., 2005), barnyardmanure (Hill et al.
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background
6,053
The degree of spermatogenic failure in these patients can vary with some producing enough sperm for intracytoplasmic sperm injection [13, 15].
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6,054
Previously, preeclampsia has been associated with intrauterine growth restriction, in the setting of dysfunctional placental vascular development and function (18).
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6,055
Further studies are still needed to exclude other purines such as ATP and related nucleotides, due to their significant release from bladder urothelium [8,9], and since ATP in some species can inhibit or relax the bladder [33–35].
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6,056
development of solutions and improvements to real-world problems (Holmström et al., 2009).
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6,057
Feature vectors were classified with a linear Support Vector Machine, for which we used the LIBLINEAR SVM library [8].
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method
6,058
sequence was obtained using the I-TASSER server, which has been developed to generate automated full-length tridimensional protein structural predictions [31-33].
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method
6,059
Social support can also affect individuals’ emotional well-being, including depression, as well as any other experienced adversities (Clara et al., 2003; Hefner & Eisenberg, 2009; Zaleski et al., 1998).
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6,060
One of our proposed protocol is based on gossip protocols for completely decentralized distributed applications, such as an environment of [19] and guarantees causal message ordering, which is somewhat similar to temporal message ordering [12], based on logical time not physical time.
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6,061
The physical basis of the particular postulated form of U in [31] remains to be elucidated.
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6,062
In this study, the Brix model [12, 13], a linear two-compartment open model where in the peripheral compartment has negligible effects on the central compartment, was used because it did not need T10 mapping or arterial input function measurements.
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method
6,063
These criteria were intentionally lenient to prevent discarding any viable results; in actuality, the real amplitudes of crustal plateau short-wavelength folds are likely on the order of 100 m [e.g., Ghent and Hansen, 1999].
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6,064
A and tiagabine in native preparations leads to significant prolongation of the postsynaptic response at GABAergic synapses (Dingledine & Korn, 1985; Roepstorff & Lambert, 1992, 1994; Thompson & Gähwiler, 1992; Isaacson, Solis & Nicoll, 1993; Draguhn & Heinemann, 1996; Engel et al., 1998; Rossi &…
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6,065
Life history traits are an appropriate and important focus for the study of the ecological and evolutionary importance of polyploidy because (1) life history traits are often main determinants of fitness (e.g., Levy and Feldman 2002; Otto 2007; Ramsey 2011), and (2), ploidy level has the potential to influence life history traits in both positive and negative ways (e.
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6,066
FIS quantifies the deviation from HWE with negative values indicating an excess of heterozygotes, and positive values indicating an excess of homozygotes (see de Meeûs et al., 2007a for a thorough explanation).
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6,067
, 2010) but also genetic or epigenetic modifications, contributing to cellular senescence (Dahl et al., 2008; Bork et al., 2010).
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6,068
…in bulk cytosolic Ca21 concentration, caused a significantly smaller activation of MAPK in comparison with that resulting from glutamate receptor stimulation, supports the hypothesis that MAPK requires high localized Ca 21 rises for its activation in neurons (Finkbeiner and Greenberg, 1996, 1997).
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result
6,069
To determine if the missing protein coding genes (belonging to the last two groups) were actually present in the draft sequence but Data is shown for six sequencing technologies; omitted is Illumina PacBio for which there are currently only eight genome projects without any missing genes. doi:10.1371/journal.pone.0048837.g006 PLOS ONE | www.plosone.org 5 December 2012 | Volume 7 | Issue 12 | e48837 had not been predicted by Prodigal, tBLASTn was used to search for those genes in the draft contigs.
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method
6,070
, 1997), have focused on representing specific tasks and domains, the attention has shifted to more general purpose schemas such as the Dialogue Act Markup using Several Layers (DAMSL) (Allen, 1997) and the ISO 24617-2(Bunt et al., 2010; Bunt et al., 2012), a standard for dialog act annotation.
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6,071
Variability in the data, in terms of variability of each behavior relative to the variability of other behaviors, and the total variance of the whole composition, is described in Appendix 3 through a variation matrix [11, 16] within each domain.
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background
6,072
5 ms than a larger response (Sanger et al. 2001; Roshan et al. 2003) because SICI depends on the inhibition of late I-waves that are only recruited in larger MEPs.
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6,073
…of people and evaluations of self are associated with medial prefrontal cortex (MPFC) and posterior cingulate cortex (PCC) activity (e.g., Vogeley et al. 2001; Harris et al. 2005; Mitchell et al. 2005; Ochsner et al. 2005; Lindner et al. 2008; Krienen et al. 2010 but see Kelley et al. 2002).
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6,074
8 percent for selected rules Snort and ClamAV, compared with several existing bit-split string matching approaches in [8], [9], [10], and [4].
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result
6,075
[43] Results from this trial have been fully reported in several published papers.[43-46] Some of the results differ slightly between published papers.
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6,076
As noted by Schoonbaert and Grainger (2004) and by Dehaene et al. (2005), in models using open-bigram coding schemes (Grainger & van Heuven, 2003; Whitney, 2001), repeated letters imply repetition at the bigram level.
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method
6,077
There is consistent evidence pointing to the contribution of a membrane receptor in dopaminergic neuroprotection exerted by estradiol [10, 33].
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6,078
We note that although PSIPRED was not optimized for peptides, the resulting fragment libraries showed in practice good coverage of the peptide conformational space (in concordance with a recent report by Vanhee et al. that most peptide-protein interactions can be represented by fragment sets derived from single, non-related monomer structures [17]).
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method
6,079
White-nose syndrome has often been assumed to be the key cause of regional population declines in hibernating bat species in the region we studied, due to repeated observations of mass mortality events associated with the disease [22,32,34,86].
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6,080
…were aimed at confirming the presence of PLCb1 in close vicinity to postsynaptic densities as previously observed by biochemical (Taguchi et al., 2007) and ultrastructural approaches (Fukaya et al., 2008), as well as to define the precise location of nuclear PLCb1 in native nervous tissue.
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result
6,081
…be accepted when different inhibitor concentrations are assayed and if consistent results are obtained as follows: the best-fitting model possesses the same number of components with the same amplitudes and kinetic constants for each tested inhibitor concentrations (Estévez and Vilanova 2009).
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6,082
Additionally, it is important to consider that most studies linking higher vancomycin MIC values to poorer therapeutic outcome have used Etest.(16,64,65) When treating individual patients with daptomycin, clinicians should also be aware that there are rare daptomycin nonsusceptible isolates present in this population of organisms.
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6,083
A stock Tween 80 conidia suspension containing 6.4 x 10 8 conidia/ml was freshly prepared according to Rosengaus et al. (1998).
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method
6,084
Nevertheless, in establishing and keeping stable social relations, ‘negative’ stimuli are necessary (Ohl, 2011).
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6,085
Similar to our results, the heart exhibited a high AhRR mRNA content (Korkalainen et al. 2004).
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result
6,086
…that the activation of mTOR signaling is necessary for the increases in protein synthesis and muscle mass that occur in response to elevated mechanical loading (Bodine et al., 2001; Drummond et al., 2009; Goodman et al., 2011a; Gundermann et al., 2014; Hornberger et al., 2004; Kubica et al., 2005).
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6,087
The balls usually have a theme that guides how HBC members will represent their categories for that ball event, along with core categories for each dominant gender, ‘butch queen’ (gay and bisexual men) and ‘femme queen’ (transgender women) (Galindo, 2013).
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6,088
This iterative method allowed for the identification, analysis and reporting of patterns (themes) that had arisen within the data (Braun and Clarke 2006).
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method
6,089
In a recent elegant study performed on choroid plexuses obtained from neonatal and adult rats and in an in vitro model of the blood-CSF barrier, the active transport of Mn through the basolateral membrane of epithelial cells was shown to be partially saturable, unidirectional (from the blood to the CSF) and influenced by prolonged exposure of both Mn and Ca (Schmitt et al., 2011).
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6,090
WAT collection and flow cytometry As we previously described (5, 11), human WAT (>150 samples) was obtained after the signature of an informed consent from women undergoing breast reconstruction.
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background
6,091
United Stated were treated with radiotherapy, and this number is expected to increase in the next several years [1].
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method
6,092
Such truncated phospholipids can activate PMNs, monocytes, eosinophils as well as platelets and are validated to be the major components of oxidized low density lipoprotein (OxLDL) that promotes atherogenesis [16,25,26] in atherosclerotic plaque [27], smokers and alcoholic blood [28,29], inflamed tissues [30] and in models of cutaneous inflammation [31].
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background
6,093
In order to discern differential sensitivity to apoptosis under NG and HG conditions HG- and NG- treated cells were exposed to the apoptotic inducer DTT [37].
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method
6,094
Moreover, canids are the only known eutherian mammals to carry a Prdm9 which has acquired disruptive mutations (Mu~noz-Fuentes et al. 2011; Ponting 2011; Axelsson et al. 2012) (a marsupial, the opossum Monodelphis domestica, has a Prdm9 which lacks zinc fingers; Ponting 2011).
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6,095
Particularly, in non-psychiatric patients, it has repeatedly been found that an increased use of maladaptive strategies, like avoidant coping and/or decreased use of adaptive strategies involving emotionfocused or problem-focused strategies were associated with suicidal behaviour (D’Zurilla et al., 1998; Li & Zhang, 2012; Pietrzak et al., 2011; Sugawara et al., 2012; Tang & Qin, 2015).
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6,096
05). by guest on O ctober 6, 2016 http://brain.oxfordjournals.org/ D ow nloaded from both KCNQ and Kir2 potassium currents (Galarraga et al., 1999; Shen et al., 2005, 2007), thereby favouring LTP induction (Calabresi et al., 2000; Bonsi et al., 2008).
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background
6,097
Thr545 of ACAP4 is a cognate substrate of MST4 Our recent work has established the essential role of MST4 in gastric parietal cell activation (11).
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background
6,098
As done by the speech expert, the feature vectors resulting from featur vector concatenation were processed by the VAD (Section 4.2).
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method
6,099
…of Ubc9 and Smt3 arrest with short spindles and high levels of Pds1 It was reported previously that yeast ubc9 D cells, which were kept alive by UBC9 expressed from the galactoseinducible GAL1-10 promoter, arrested in mitosis upon promoter shut-off in glucose medium (Seufert et al ., 1995).
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