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5,000
We include treatment with an angiotensin-converting enzyme inhibitor and thiazide diuretic for those without CVD or cerebrovascular disease history, while including beta-blockers for those with such a history, as per WHO guidelines further detailed in Text S1 [16,25].
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method
5,001
Most algorithms proposed for mining closed patterns require all candidates found so far to be kept in memory to avoid duplicates [9, 11, 12].
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background
5,002
Moreover HDAC1 is not crucial for enzymatic function of HDAC2 in embryonic stem cells, however overexpression of HDAC2 cannot compensate for the loss of HDAC1 (Lagger et al., 2002).
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background
5,003
Going beyond a linear predictor, we used two implementations of SVMs, SVM-light [36] and Partek (Partek Software, http://www.partek.com), and examined radial, polynomial, and sigmoid kernels.
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method
5,004
In addition, previous studies have shown that myocardial scar size and characteristics predict spontaneous ventricular arrhythmias in patients with an ischemic cardiomyopathy [25–28] which can result in worse survival independent of LV functional improvement.
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result
5,005
This increase activates the Na/Ca exchanger, which leads to an increase in cytosolic Ca [21, 23, 33, 64, 100, 101, 107–115].
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background
5,006
Also, a recent study suggested that retinopathy of prematurity (ROP) may be increased due to INDO [20].
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background
5,007
We expected partners with a lower level of education to be more vulnerable to high distress [13] and partners’ level of distress in the long term to influence that of the patients [10].
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background
5,008
Finding a serum -hCG level greater than the discriminatory zone, in combination with an indeterminate ultrasonography, has been shown to be associated with ectopic pregnancy.(8,9) Typical transvaginal discriminatory zone values in the literature range from 1,500 to 3,000 mIU/mL and have largely been developed according to radiology-performed ultrasonography in outpatients,(10) with intrauterine pregnancy defined as the visualization of a gestational sac.
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background
5,009
Excess glutamate and excitotoxicity also contributes to epilepsy (Meldrum, 1994), and causes seizures in animal models.
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background
5,010
Fractions 1, 2 and 3 were identified to contain different proteases, while fraction 4 showed four main peaks PhTx1, PhTx2, PhTx3 and PhTx4, containing polypeptides and enhancing different toxicological effects [19,20].
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background
5,011
PerRBS regulon genes includes katA, ahpCF, hemAXCDBL, mrgA, pfeT (formerly zosA), fur, and perR (Fuangthong et al., 2002; Guan et al., 2015).
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background
5,012
Immunoaffinity purification of TLA. mAb G19 recognizes an extracellular epitope associated with the tip link (Goodyear and Richardson, 2003).
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background
5,013
Recent advanced templatebased approach (17) and new approaches with R2* to HU conversion (41) and zero-echotime (42) show similar results to our approach and/or great potential for further improvement of MR-AC.
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result
5,014
…one another in many acoustic features, such as Voice Onset Time (VOT), fundamental frequency, and the amplitude difference between the first harmonic and the second one (Cho et al. 2002, Han and Weitzman 1970, Kang 2014, Lisker and Abramson 1964, Oh 2011, Silva 2006, Wright 2007, among others).
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background
5,015
The RDCs have been successfully applied in the refinement of protein structures (Stauffer et al. 2002), nucleic acids (McCallum and Pardi 2003) and protein– RNA complexes (Bayer et al. 1999).
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method
5,016
As anticipated, FLNA(16-23) did not affect β-arr2 interaction with ICL3ΔCt (Figure 7B), but partially inhibited β-arr2 binding to ICL3 (Figure 7C); we were unable to saturate ICL3 at the FLNA(16-23) concentration used (400 nM), which might explain this partial inhibition.
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background
5,017
A number of studies, using closed DNA minicircles or plasmids that lack free ends, have shown that Ku also exhibits sequence-specific DNA binding to regulatory DNA elements effecting gene transcription and DNA replication [13, 54].
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background
5,018
We shall compare our iterative process with the algorithm [25] to help understanding our extended version.
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method
5,019
If too many side-effects are found with currently available hypnotics, it will be of interest to determine whether newer genetic methods for enhancing sleep in rodents can reverse/attenuate or slow-down Alzheimer's pathology in rodent models (Jego et al., 2013; Konadhode et al., 2013; Anaclet et al., 2014).
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background
5,020
Using this KO model, DRA was found to contribute significantly to transcellular oxalate absorption, accounting for 42, 57 and 41% of J ms across the distal ileum, cecum and distal colon, respectively [17].
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method
5,021
Prdm1 (encoding Blimp-1) has known roles in effector CD8+ and CD4+ T cell differentiation (Rutishauser et al., 2009; Shin et al., 2009; Johnston et al., 2009).
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background
5,022
Intriguingly, using MPRs-deficient MEF cells, mouse and human CLN5 have been shown to reach lysosomes in an MPRindependent manner [12].
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method
5,023
This area has been the subject of a great deal of recent interest [1, 7, 11, 14, 20].
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background
5,024
In other words, the selectively bred animals would mainly differ in trait anxiety, which is an enduring feature of an individual and, consequently, does not vary from moment to moment, in contrast to state anxiety, which is provoked by an anxiogenic stimulus and only experienced at a particular moment in time (Belzung & Griebel, 2001; Lister, 1990).
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background
5,025
Hearts were excised and perfused retrograde via the aorta with modified Krebs-Henseleit (K-H) buffer oxygenated with 95% O2-5% CO2 as previously described (12).
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method
5,026
Buccal swabs from 379 IWHs were taken using Isohelix DNA Buccal Swabs (Cell Projects Ltd. UK).
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method
5,027
As reported in a previous study (18), Dox-induced myocardial accumulation of LC3 and p62 proteins indicates a possible impairment of autophagic degradation.
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background
5,028
It was suggested that the enhanced sympathetic nervous system resulting from a low protein diet increased cell proliferation and enhanced gastric carcinogenesis [77].
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background
5,029
Additionally, several authors have reported cases where prolactin secreting adenomas either came to diagnosis or increased in size after exogenous estrogen administration or during pregnancy [4,5,7,8,9].
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background
5,030
Although phase 1 frequency decays rapidly and substantially, generating a wide range of instantaneous frequencies in a short period (Krans and Chapple 2005), the CoV was still less than those computed for phase 2 and 3 distributions.
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background
5,031
It is well known that dexketoprofen acts principally through inhibiting COX-1 [15], and meloxicam is a selective and specific COX-2 inhibitor [4, 10].
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background
5,032
To confirm these findings and explore which stage of the S-phase checkpoint pathway is defective in ctf18–2A cells, we examined the Mec1-dependent phosphorylation of the CMG helicase (42).
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method
5,033
However, two other groups found that excitatory transmission was depressed only in wildtype mice (Kawamura et al., 2006; Takahashi and Castillo, 2006).
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background
5,034
…cocaine seeking is at peak levels between WD30 and WD90 and is accompanied by increased BDNF levels, incubation of sucrose seeking in rats is much less persistent, returning to basal levels by WD90, and is not associated with increased BDNF levels in the NAc (Grimm et al., 2003; Lu et al., 2004c).
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background
5,035
For example, the maximum total cardiac output at 23 ˚C in Reeves’s study was around 30–40 ml min21 kg21, a value considerably lower than that reported by Shelton and Burggren (1976).
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background
5,036
This pattern of crypt hyperplastic enteropathy also characterizes many infective states [21, 22], but in our Zambian population villous height and crypt depth are positively correlated [18], as occurs during starvation [23].
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background
5,037
…even after the sensory input has been restored with CI technology, CI users show higher cross-modal activation in both visual and auditory cortex compared to normal hearing (NH) controls (Chen et al., 2016; Giraud et al., 2001a; Giraud et al., 2001b; Sandmann et al., 2012; Stropahl et al., 2016).
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background
5,038
We also calculated home range fidelity, defined as the percentage of the total accumulated home range used during each year or study period (Laver and Kelly 2008; Börger et al. 2008).
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method
5,039
Results can be returned in various forms, including the SZS-compliant result status used in the CASC [27, 36] competition for automated theorem provers.
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method
5,040
Regardless of these differences, the results from both studies that used sites located in the 2004/2005 Alaska fire events were substantially different from previous findings from research in Canada, where the residual organic layers under trees were substantially shallower than the organic layers from across the plot (Miyanishi and Johnson, 2002; Greene et al., 2007).
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result
5,041
IF cells were lysed in lysis buffer (Iwatani et al., 2005) at 55 1C overnight, and the genomic DNA was extracted using the standard method of phenol-chloroform extraction.
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method
5,042
It also extends the number of dendrophylliid corals known from the Azores to eight (Braga-Henriques et al. 2013).
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background
5,043
Model calculations overpredicted the OH concentrations (Mao et al., 2009), particularly at altitudes less than 2 km, but found the overprediction to correlate with HCHO concentrations, indicating missing reactive VOCs in the model (Mao et al.
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background
5,044
The concerns around these have therefore not been about being medically unsafe, but about their marketing potentially overstating product effectiveness and exploiting existing sociocultural biases (Karnani, 2007; Agarwal and Roy, 2012).
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background
5,045
of the mice (n = 89) that were phenotyped for innominate artery atherosclerosis, an artery that recapitulates human atherosclerosis [40].
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background
5,046
The randomized response technique for polling was first introduced in 1965 [25].
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background
5,047
…previously identified POR genes, AtPORC is not expressed so strong in early seedling development, but its transcript levels increase in etiolated seedlings by illumination and are predominantly detectable in older seedlings and adult plants (Oosawa et al. 2000; Su et al. 2001; Frick et al. 2003).
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background
5,048
Moreover, increasing number of studies has been carried out with multi-channel measurements with an aim to analyze the characteristics with respect to different auscultation locations simultaneously [1, 2].
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background
5,049
Parallelization with GNU parallel To get the subset of results related to the e-commerce packages of interest, we merged the top 40 list provided by Robertshaw, the top ten of builtwith.comand the leading systemsfrom the Gartner and Forresterreports, as already mentioned.
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method
5,050
PS36 was used previously in a P. sojae genetic population study (Dorrance and Grünwald 2009), and P74-75 amplified interspecific polymorphic bands of P. sojae, P. rubi, and P. europea (Schena et al. 2008).
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method
5,051
Previous studies have demonstrated that ixazomib has a shorter proteasome dissociation half-life, a larger blood volume distribution at a steady state, and a greater and more constant biodistribution than bortezomib [4, 14, 17].
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background
5,052
Under mild regularity conditions on the densities (see Hyvärinen, 2005; Sriperumbudur et al., 2017, and below), the score can be rewritten J(p0||pT ) =E [ d∑ i=1 ∂2i Tx(y) + 1 2(∂iTx(y)) 2 ] +E [ d∑ i=1 ∂iTx(y)∂i log q0(y) ] + J(p0||q0) where J(p0||q0) is a constant term for the optimization…
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background
5,053
Sustained interest exists to numerically model electromagnetic (EM) fields produced by radiators embedded within planar-layered media of diverse anisotropy and loss [1]–[3].
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background
5,054
…bird species), it is males that suffer from higher mortality when the parental effort is increased; this may be because males tend to adjust their investment according to brood size while females are working on their maximum level irrespective of the current brood size (Santos and Nakagawa 2012).
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background
5,055
No, or very few, UB-IG have been found in the mouse (Grozdanovic et al. 1992) and rat (Gabella and Uvelius 1990).
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background
5,056
In [12] the authors give upper and lower bound of the message delivery delay in multi-copy message routing scheme.
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background
5,057
These results are in accord with a general model for deuteromycete fungal isolate comparisons described by Maurer et al (125); both MetarhiziumandBeauveria are generalist fungal genera, which sometimes specialize on insects.
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result
5,058
The free cytosolic ADP concentration ([ADP]) was calculated according to the method previously described by Kemp and coworkers (33), assuming that PCr represents 85% of the total creatine content (Cr PCr) (7):
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method
5,059
For example, in the liver, pancreas, lung, and intestine, Sox9-positive cells can generate new daughter cells and differentiate into functional cells in damaged organs (Antoniou et al., 2009; Reginensi et al., 2011; Seymour et al., 2007; Turcatel et al., 2013; Vidal et al., 2005).
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background
5,060
Until now, research has mainly focused on the biological activities of chemicals extracted from the seeds and roots of J. mandshurica (Lee et al., 2000; Li et al., 2003a, 2003b; Min et al., 2002; Kim et al., 1998; Sugie et al., 1998), with few reports on the bioactive chemicals from the leaves.
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method
5,061
Therefore, we adopted ClinVar [50] to map all the HPO terms to UMLS, and utilized SIDD [51] to map all the disease names in DO to MeSH ID, provided that there are direct mappings between MeSH ID and UMLS.
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method
5,062
Increased tract size may be selectively favoured to grant females greater control over fertilization under sperm competition (Birkhead 1995).
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background
5,063
The results for veridical recall replicated previous results in the literature (Bal- lardini et al., 2008; McDermott & Watson, 2001), with the average recall of studied words increas- ing monotonically as SOA increased.
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result
5,064
Our results are consistent with several studies that have found increases in soil C following conversion of forest to other land uses, primarily pasture (Lugo and Brown, 1993; Fisher et al., 1994; Neill et al., 1997b) and contrast with studies that have found decreases in soil C following conversion (Veldkamp, 1994; Van Dam et al.
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result
5,065
This is supported by evidence that the degree of locomotion following administration of rewarding drugs correlates with extracellular DA levels in Nac (Miczek et al., 2011, Shimamoto et al., 2011, Valenti et al., 2012).
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background
5,066
Further complicating the issue, social desirability, varied interpretations of questions, and problems in recall can impede accurate measurements of risky sexual behavior (Brewer, Garrett, & Kulasingam, 1999; Brody, 1995; Schroder et al., 2003).
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background
5,067
…we recently demonstrated the important role of another 89-kDa periplasmic protein localized in the invasion tip during bacterial escape from the host digestive vacuole, migration through the host cytoplasm towards the target nucleus, and invasion into the macronucleus (Iwatani et al., 2005).
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background
5,068
Dynamic strain measurement in distributed fiber optic sensing (DFOS) is essential for structural health monitoring (SHM) of the strain changes induced by aging material and seismic or man-made activities [1].
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background
5,069
Giles (2005) found almost 14,000 citations in WoS for a paper in Science by Saiki et al. (1988) on the polymerase chain reaction, identifying it as the most highly cited paper ever to appear in that journal, whereas GS returned just under 3000 citations.
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background
5,070
It is the P450’s unique capacity to selectively oxygenate inactive carbons that provides biosynthesis with its competitive advantage over traditional chemical approaches (20, 21).
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background
5,071
In accordance to these results, recent work from our laboratory has shown decreased pulmonary expression of PPARc and BMPR2 signalling in the vasculature of nitrofen-induced CDH lungs on day 21 [6, 31].
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result
5,072
To examine whether these signaling pathways were involved in lung tumor exosome-mediated adipogenic inhibition of hAD-MSCs, we blocked these signaling with respective pathway inhibitor SB431542 [18], SP600125 [19], LY294002 [20], U0126 [21], and SB203580 [19] followed by tumor exosome treatment.
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method
5,073
Buck, unpublished observations), nitric oxide synthase expression and activity resulting in the synthesis of NO, which interacts with superoxide to generate peroxynitrite (33, 48), a compound highly reactive with sulfur-containing amino acids, such as Cys (12).
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background
5,074
The present study findings concur with previous reports in that when bone defects occur they are commonly on the tibial side (3,11,22,24).
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result
5,075
To ensure the quality of our implementation, we consulted the author and obtained comparable results when our implemented algorithm was tested under similar conditions as in [21].
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result
5,076
…difference between aspirated and lenis is merging for younger speakers, resulting in a two-way VOT contrast: aspirated & lenis (long VOT) vs. tense (short VOT) (Choi 2002, Kang and Guion 2008, Kang 2014, Kim 2000, Kim 2004, Kong et al. 2011, Lee and Jongman 2012, Oh 2011, Silva 2006, Wright 2007).
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background
5,077
The receiver operator characteristic (ROC) curve shows the tradeoff between sensitivity and specificity as one changes the cut-off values for positivity.(9,10) The sensitivity versus 1-specificity plot in ROC space is called ROC curve.
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background
5,078
Because there was no rat ATP5G3 cDNA sequence available in GenBank databases, for ATP5G3 coding sequence information, the rat pancreatic cDNA library was screened via PCR with ATP5G3 gene-specific primers (Table 1) that were designed based on the human ATP5G3 cDNA sequence (U09813) (50).
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method
5,079
Previously, we reported the occurrence of 2,6-dihydroxybenzoate decarboxylase in A.tumefaciens IAM12048 (Yoshida et al. 2004a).
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background
5,080
While much is known about the sympathetic regulation of cardiac function in health and disease, less interest has been paid to the parasympathetic branch of the autonomic nervous system [66].
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background
5,081
Sequences include those for AcMNPV (7), Orgyia pseudotsugata MNPV (OpMNPV) (3), BmNPV (25), LdMNPV (40), SeMNPV (37), XcGV (30), PxGV (28), HaSNPV G4 (13), Helicoverpa armigera NPV (HaNPV) (GenBank accession number NC_003094), SpltMNPV (50), CpGV (46), CuniNPV (2), E.
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background
5,082
Even though chyle has been defined as a noninflammatory fluid, inflammation is part of themechanism responsible for the presence of this type of fluid in pleural and peritoneal cavities as in other forms of serositis associated in SLE [3].
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background
5,083
An alternate theory suggests the formation of free radicals by incident laser energy and light absorption by fungal pigment xanthomegnin, present in high concentration in Trichophyton rubrum [13].
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background
5,084
In long-term experiments, as those for investigating the apoptotic effect of arachidonic acid, a complete cultivation medium was required to ensure optimal growth conditions (Dymkowska et al., 2006).
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background
5,085
Human serum may be used as a substrate for ESC culture (Xu et al., 2001; Amit et al., 2004; Beattie et al., 2005; Stojkovic et al., 2005a; Fletcher et al., 2006; Braam et al., 2008; Miyazaki et al., 2008; Baxter et al., 2009; Valamehr et al., 2011).
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background
5,086
Letters have a broad spatial frequency spectrum, but the most important frequency of a letter is thought to be :2 cycles per letter width [16,17].
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background
5,087
At the level of strategical planning, both Nederlandse Spoorwegen and Deutsche Bahn AG use software which is based on the PESP-model ([19, 11]).
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method
5,088
Antibodies for immunohistochemistry were: anti-FSP1 rabbit polyclonal antibody, 1:1,000 (7, 8); FITC- or P6-labeled goat anti-rabbit IgG (Vector Laboratories Inc.
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background
5,089
…of three transcription factors that regulate expression of genes involved in lipid homeostasis and glucose metabolism (Jeon and Osborne, 2012; Raghow et al., 2008), and Srebp1/2 are known to interact with Hmgb1/2; their activity has been reported to be enhanced by Hmgb1 (Najima et al., 2005).
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background
5,090
The contradictory findings that human p60 binds stably to microtubules in vitro but never co-localizes with microtubules in vivo (McNally and Thomas, 1998) suggested that katanin might interact transiently with microtubules in vivo.
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background
5,091
…the mouse heart was lost after ADX (Oishi et al., 2006) and the circadian expression of heart mPai-1 was completely abolished in Clockmutant mice (Minami et al., 2002; Oishi et al., 2005a), these results suggest that the distal mPai-1 E-box identified here is a target for GC action and may…
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background
5,092
We used xtcsd routine in STATA, developed by De Hoyos and Sarafidis (2006) to check such assumptions in STATA.
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method
5,093
Murray [3] used gait to classify the pathologically abnormal patients into different group for appropriate treatment.
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method
5,094
This result supports the hypothesis of a stronger role for BDNF during childhood when, in addition to the presence of lower BDNF levels (Casey et al., 2009), neuronal networks dependent of neural plasticity (Angelucci et al.
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result
5,095
…skeletal muscle lipid esters have been shown to be related to variations in insulin sensitivity (16:0, 16:1, 18:2 n-6, 20:3 n-6, 20:4 n-6 and SFA) (Salomaa et al., 1990; Borkman et al., 1993; Vessby et al., 1994, 2002; Pan et al., 1995; Lovejoy et al., 2001; Pelikanova et al., 2001; Vessby, 2003).
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background
5,096
Recent advances in biliary drainage techniques have dramatically improved the mortality rate from [40% before the 1970s [7–9] to the more recent rate of \20% [10, 11].
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background
5,097
There are several advanced statistical sampling techniques, such as the repeated runs and batch means methods [11], whereby point-estimate predictions are possible using only a few (about 30 [12, 11]) i.
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background
5,098
The accuracy of predictions is measured in average precision (AP; equivalently, the area under the precision-recall curve) evaluated based on Sym criteria adopted from [5]: Based on Sym, a hypothesis is accepted (considered as a true positive) if the distance to ground-truth is smaller than 0.
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method
5,099
In a study in Vancouver, Brauer et al. (2008) found significant negative associations between NO2 exposure and fetal growth when they used an AQMS-based approach, but no association when they used a LUR model.
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background