mihirhirave/entity_extraction_ade_v2_with_validation

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1. Changes in the plasma cortisol level were reported in a male patient with panic disorder during the period of low-dose alprazolam treatment (mean 0.62 +/- 0.15 mg/day) compared with during the period of high-dose period (mean 1.08 +/- 0.28 mg/day).	[ { "ade": "Changes in the plasma cortisol level", "drug": "alprazolam" } ]
The temporal sequence of the respiratory insufficiency and the histopathology, when compared to the previous examples in the literature, suggest that cyclophosphamide was aetiologically responsible for the lung disease.	[ { "ade": "lung disease", "drug": "cyclophosphamide" }, { "ade": "respiratory insufficiency", "drug": "cyclophosphamide" } ]
Its overall toxicity is considerably less compared to standard induction chemotherapy; however, it is associated with a high incidence of a potentially fatal symptom complex referred to as "retinoic acid syndrome." This report describes a patient with APL who developed the syndrome a few weeks after initiating induction therapy with ATRA despite being treated for hyperleukocytosis.	[ { "ade": "potentially fatal symptom", "drug": "retinoic acid" }, { "ade": "retinoic acid syndrome", "drug": "retinoic acid" }, { "ade": "toxicity", "drug": "retinoic acid" } ]
Cessation of D-Pen and the start of corticosteroid therapy were followed by recovery from bicytopenia.	[ { "ade": "bicytopenia", "drug": "D-Pen" } ]
Colchicine-induced myopathy in a teenager with familial Mediterranean fever.	[ { "ade": "myopathy", "drug": "Colchicine" } ]
Goiter and hypothyroidism during re-treatment with amiodarone in a patient who previously experienced amiodarone-induced thyrotoxicosis.	[ { "ade": "thyrotoxicosis", "drug": "amiodarone" }, { "ade": "hypothyroidism", "drug": "amiodarone" }, { "ade": "Goiter", "drug": "amiodarone" } ]
Hair loss associated with paroxetine treatment: a case report.	[ { "ade": "Hair loss", "drug": "paroxetine" } ]
Methotrexate-induced hepatic necrosis requiring liver transplantation in a patient with rheumatoid arthritis.	[ { "ade": "hepatic necrosis", "drug": "Methotrexate" } ]
Successful treatment of hyperthyroidism with amiodarone in a patient with propylthiouracil-induced acute hepatic failure.	[ { "ade": "acute hepatic failure", "drug": "propylthiouracil" } ]
We report an unusual case of simultaneous transitional cell carcinoma of the renal pelvis and distal ureter without transitional cell carcinoma of the bladder occurring after chronic cyclophosphamide therapy for nonHodgkin's lymphoma.	[ { "ade": "transitional cell carcinoma of the renal pelvis", "drug": "cyclophosphamide" }, { "ade": "distal ureter without transitional cell carcinoma of the bladder", "drug": "cyclophosphamide" } ]
We report a case of secondary glaucoma caused by epithelial downgrowth in which filtration surgery was performed with adjunctive use of subconjunctival 5-fluorouracil.	[ { "ade": "glaucoma", "drug": "5-fluorouracil" } ]
The patient described feeling cold with worsening headache and chills approximately one hour after infusion of the first dose of penicillin.	[ { "ade": "worsening headache", "drug": "penicillin" }, { "ade": "feeling cold", "drug": "penicillin" }, { "ade": "chills", "drug": "penicillin" } ]
OBSERVATIONS: A 48-year-old woman presented with disfiguring facial edema 10 weeks after she began antiviral therapy with peginterferon alfa-2a and ribavirin for chronic hepatitis C infection.	[ { "ade": "disfiguring facial edema", "drug": "ribavirin" }, { "ade": "disfiguring facial edema", "drug": "peginterferon alfa-2a" } ]
This is the first description, to our knowledge, of ductopenia apparently caused by clindamycin.	[ { "ade": "ductopenia", "drug": "clindamycin" } ]
Visual hallucinations associated with zonisamide.	[ { "ade": "Visual hallucinations", "drug": "zonisamide" } ]
Severe loss of vision after removal of cataract caused by intravitreal triamcinolone in combination with photodynamic therapy for exudative age-related macular degeneration.	[ { "ade": "Severe loss of vision", "drug": "triamcinolone" }, { "ade": "cataract", "drug": "triamcinolone" } ]
There was a clear relationship between restarting the Accutane and recurrence of the transient myopia.	[ { "ade": "transient myopia", "drug": "Accutane" } ]
The purpose of this article is to present the first case-series of posterior reversible encephalopathy syndrome (PRES) associated with L-asparaginase treatment.	[ { "ade": "PRES", "drug": "L-asparaginase" }, { "ade": "posterior reversible encephalopathy syndrome", "drug": "L-asparaginase" } ]
A 36-y-o patient with schizophrenia, who had consumed gradually increasing quantities of oolong tea that eventually reached 15 L each day, became delirious and was admitted to a psychiatric hospital.	[ { "ade": "delirious", "drug": "oolong tea" } ]
Acute kidney injury caused by zonisamide-induced hypersensitivity syndrome.	[ { "ade": "Acute kidney injury", "drug": "zonisamide" }, { "ade": "hypersensitivity syndrome", "drug": "zonisamide" } ]
Cardiomyopathy after widely separated courses of adriamycin exacerbated by actinomycin-D and mithramycin.	[ { "ade": "Cardiomyopathy", "drug": "adriamycin" }, { "ade": "Cardiomyopathy", "drug": "mithramycin" }, { "ade": "Cardiomyopathy", "drug": "actinomycin-D" } ]
Albeit rare among Western patients, such lithium-associated thyroid dysfunctions appeared to be more likely to occur in Hong Kong Chinese.	[ { "ade": "thyroid dysfunctions", "drug": "lithium" } ]
We report a case of severe hypotension associated with intravenous valproate used to treat status epilepticus in an 11-year-old girl.	[ { "ade": "hypotension", "drug": "valproate" } ]
Generalised pustular psoriasis induced by cyclosporin a withdrawal responding to the tumour necrosis factor alpha inhibitor etanercept.	[ { "ade": "Generalised pustular psoriasis", "drug": "cyclosporin a" } ]
The ocular toxicity of DCF, previously described as conjunctivitis, appears to be a keratitis of moderate severity which requires further study.	[ { "ade": "keratitis", "drug": "DCF" }, { "ade": "conjunctivitis", "drug": "DCF" }, { "ade": "ocular toxicity", "drug": "DCF" } ]
This case is remarkable since 1) ECM developed after subcutaneous and not after intramuscular injection, 2) the injection was given by the patient himself, and 3) glatiramer acetate can induce skin necrosis as a side effect.	[ { "ade": "skin necrosis", "drug": "glatiramer acetate" } ]
We report the successful treatment of heparin-induced thrombocytopenia and subsequent hemorrhagic complications postoperatively in a 2-year-old child with Danaparoid (orgaran).	[ { "ade": "hemorrhagic complications", "drug": "heparin" }, { "ade": "thrombocytopenia", "drug": "heparin" } ]
Gynecomastia in epileptics treated with phenobarbital, phenytoin and fluoresone: two case reports.	[ { "ade": "Gynecomastia", "drug": "phenobarbital" }, { "ade": "Gynecomastia", "drug": "fluoresone" }, { "ade": "Gynecomastia", "drug": "phenytoin" } ]
There have been only two reports of cimetidine-induced hepatitis.	[ { "ade": "hepatitis", "drug": "cimetidine" } ]
Fixed drug eruption in hands caused by omeprazole.	[ { "ade": "eruption", "drug": "omeprazole" } ]
The authors conclude that among patients taking high doses of oral niacin only those who experience visual symptoms need to be ophthalmologically evaluated.	[ { "ade": "visual symptoms", "drug": "niacin" } ]
HUS has been reported after several anticancer chemotherapies and most often after mitomycin C-based chemotherapy regimens.	[ { "ade": "HUS", "drug": "mitomycin C" } ]
A drug interaction between zafirlukast and theophylline.	[ { "ade": "drug interaction", "drug": "zafirlukast" }, { "ade": "drug interaction", "drug": "theophylline" } ]
Animals treated with HAL showed a highly significant 32%-46% loss of tyrosine hydroxylase (TH) immunoreactive neurons in the substantia nigra, and 20% contraction of the TH stained dendritic arbour.	[ { "ade": "significant 32%-46% loss of tyrosine hydroxylase (TH) immunoreactive neurons", "drug": "HAL" } ]
After extensive neurological 'work up', we realized that the anisocoria was related to the transdermal scopolamine patch that we had prescribed for weaning off the opioid.	[ { "ade": "anisocoria", "drug": "scopolamine" } ]
Cephalexin rash in infectious mononucleosis.	[ { "ade": "Cephalexin rash", "drug": "Cephalexin" } ]
Propylthiouracil-induced sensorineural hearing loss associated with antineutrophil cytoplasmic antibodies.	[ { "ade": "sensorineural hearing loss", "drug": "Propylthiouracil" }, { "ade": "antineutrophil cytoplasmic antibodies", "drug": "Propylthiouracil" } ]
Favorable outcome of de novo hepatitis B infection after liver transplantation with lamivudine and adefovir therapy.	[ { "ade": "hepatitis B infection", "drug": "adefovir" }, { "ade": "hepatitis B infection", "drug": "lamivudine" } ]
We report a case of drug-induced pemphigus caused by an angiotensin-converting enzyme inhibitor, captopril.	[ { "ade": "pemphigus", "drug": "captopril" } ]
Reactivation of cytomegalovirus probably followed the treatment of Wegener's granulomatosis with corticosteroids and azathioprine.	[ { "ade": "Reactivation of cytomegalovirus", "drug": "azathioprine" } ]
In addition to its known effect on gallbladder stasis, octreotide alters bile acid composition and may thus hasten intrahepatic sludge and stone formation.	[ { "ade": "alters bile acid composition", "drug": "octreotide" }, { "ade": "stone formation", "drug": "octreotide" }, { "ade": "gallbladder stasis", "drug": "octreotide" }, { "ade": "hasten intrahepatic sludge", "drug": "octreotide" } ]
Two patients who were receiving Tolazoline by infusion developed duodenal ulceration and subsequent intestinal perforation.	[ { "ade": "duodenal ulceration", "drug": "Tolazoline" }, { "ade": "intestinal perforation", "drug": "Tolazoline" } ]
Cardiac arrest following use of sumatriptan.	[ { "ade": "Cardiac arrest", "drug": "sumatriptan" } ]
To our knowledge , this is the first reported case of bromide intoxication due to pyridostigmine bromide administration.	[ { "ade": "bromide intoxication", "drug": "pyridostigmine bromide" } ]
All developed mucocutaneous side effects within 20 weeks of beginning im gold therapy, at a time when RA had improved markedly compared to pretreatment status.	[ { "ade": "mucocutaneous side effects", "drug": "gold" } ]
Acute vision loss after intravitreal injection of bevacizumab (avastin) associated with ocular ischemic syndrome.	[ { "ade": "Acute vision loss", "drug": "bevacizumab" }, { "ade": "ocular ischemic syndrome", "drug": "bevacizumab" }, { "ade": "ocular ischemic syndrome", "drug": "avastin" }, { "ade": "Acute vision loss", "drug": "avastin" } ]
Life-threatening alterations in heart rate after the use of adenosine in atrial flutter.	[ { "ade": "alterations in heart rate", "drug": "adenosine" } ]
Toxic epidermal necrolysis after the use of high-dose cytosine arabinoside.	[ { "ade": "Toxic epidermal necrolysis", "drug": "cytosine arabinoside" } ]
We describe a patient with transitional cell carcinoma of the renal pelvis who developed respiratory dysfunction and an abnormal chest x-ray with diffuse interstitial opacities while on chemotherapy with piritrexim, a methotrexate analog.	[ { "ade": "abnormal chest x-ray with diffuse interstitial opacities", "drug": "piritrexim" }, { "ade": "respiratory dysfunction", "drug": "piritrexim" } ]
Acute hemorrhagic gastritis associated with acetazolamide intoxication in a patient with chronic renal failure.	[ { "ade": "acetazolamide intoxication", "drug": "acetazolamide" }, { "ade": "Acute hemorrhagic gastritis", "drug": "acetazolamide" } ]
A patient developed transient, acute myopia while on isotretinoin (Accutane) therapy for acne.	[ { "ade": "acute myopia", "drug": "isotretinoin" }, { "ade": "acute myopia", "drug": "Accutane" } ]
This increase when clozapine was switched to risperidone and vice versa is consistent with our previous report of elevated serum triglyceride levels in clozapine-treated patients.	[ { "ade": "elevated serum triglyceride levels", "drug": "clozapine" } ]
We report a case of noncardiogenic pulmonary edema developed after therapeutic trial of EO as sclerosing agent for esophageal varix.	[ { "ade": "noncardiogenic pulmonary edema", "drug": "EO" } ]
The temporal relationship suggests that the spinal cord infarction may be related to the use of zolmitriptan.	[ { "ade": "spinal cord infarction", "drug": "zolmitriptan" } ]
There is a putative role of liothyronine administration in precipitating or activating hyperthyroidism.	[ { "ade": "hyperthyroidism", "drug": "liothyronine" } ]
CASE: We report a case of a woman with severe human insulin-induced lipoatrophy who has been treated exclusively with recombinant DNA human insulin since the onset of IDDM.	[ { "ade": "lipoatrophy", "drug": "human insulin" }, { "ade": "lipoatrophy", "drug": "recombinant DNA human insulin" } ]
Phenytoin toxicity: an easily missed cause of cerebellar syndrome.	[ { "ade": "cerebellar syndrome", "drug": "Phenytoin" } ]
Myoclonus was induced and enhanced by L-dopa, developing into generalized seizures.	[ { "ade": "Myoclonus", "drug": "L-dopa" }, { "ade": "generalized seizures", "drug": "L-dopa" } ]
Possible mechanisms for damage to the urothelium by ketamine are suggested.	[ { "ade": "damage to the urothelium", "drug": "ketamine" } ]
Successful challenge with clozapine in a history of eosinophilia.	[ { "ade": "eosinophilia", "drug": "clozapine" } ]
The pro-arrhythmic effects of procainamide may be explained on the basis of both its vagolytic action on the atrioventricular node as well as by prolongation of refractoriness in the accessory pathway.	[ { "ade": "pro-arrhythmic effects", "drug": "procainamide" } ]
Bone marrow aplasia and severe skin rash after a single low dose of methotrexate.	[ { "ade": "severe skin rash", "drug": "methotrexate" }, { "ade": "Bone marrow aplasia", "drug": "methotrexate" } ]
We describe a case of a man treated with an EGFR-inhibitor (erlotinib) for a cell lung cancer who developed skin manifestations localized in an uncommon area and with an atypical evolution.	[ { "ade": "skin manifestations", "drug": "erlotinib" } ]
We present a case of a diabetic patient taking glyburide who was prescribed ciprofloxacin and developed prolonged hypoglycemia, which persisted for over 24 hours.	[ { "ade": "prolonged hypoglycemia", "drug": "ciprofloxacin" }, { "ade": "prolonged hypoglycemia", "drug": "glyburide" } ]
CASE SUMMARY: A 68-year-old woman developed a dry, irritating cough within one month of starting quinapril therapy for the treatment of essential hypertension.	[ { "ade": "irritating cough", "drug": "quinapril" } ]
DISCUSSION: Rhabdomyolysis is a clinical syndrome resulting from the destruction of skeletal muscle that may progress to renal failure Several drugs have been associated with rhabdomyolysis, including lovastatin, a hydroxymethylglutaryl-coenzyme A reductase inhibitor.	[ { "ade": "rhabdomyolysis", "drug": "lovastatin" } ]
A patient with coccidioidal meningitis was treated with intrathecally administered amphotericin B, and an acute toxic delirium with EEG abnormalities developed.	[ { "ade": "EEG abnormalities", "drug": "amphotericin B" }, { "ade": "acute toxic delirium", "drug": "amphotericin B" } ]
Severe acidosis from acetazolamide in a diabetic patient.	[ { "ade": "Severe acidosis", "drug": "acetazolamide" } ]
We report three cases of patients who developed leukopenia during olanzapine treatment.	[ { "ade": "leukopenia", "drug": "olanzapine" } ]
We report a case of Ritalin-associated cataract and glaucoma.	[ { "ade": "cataract", "drug": "Ritalin" }, { "ade": "glaucoma", "drug": "Ritalin" } ]
OBJECTIVE: To our knowledge, this is the first published case report of an adolescent girl with a mitochondrial disorder and depression who displayed both new-onset psychotic and increased mood symptoms during treatment with risperidone.	[ { "ade": "increased mood symptoms", "drug": "risperidone" } ]
CONCLUSION: The present findings suggest that: (i) amantadine probably exerts its anti-dyskinetic effect by acting on the "indirect" pathway; (ii) the pathophysiological mechanisms of subthalamotomy induced dyskinesias may differ from those involved in L-dopa induced dyskinesias; (iii) dyskinesias induced by STN surgery resolve spontaneously as compensatory mechanisms develop.	[ { "ade": "dyskinesias", "drug": "L-dopa" } ]
The intramuscular challenge test with 25 UI of Miacalcic was positive with an immediate anaphylactic reaction.	[ { "ade": "anaphylactic reaction", "drug": "Miacalcic" } ]
Atrial fibrillation after vardenafil therapy.	[ { "ade": "Atrial fibrillation", "drug": "vardenafil" } ]
The patient was enrolled in a weight-loss clinic, and his diabetes medications were adjusted.Subsequently, olanzapine was discontinued because of weight gain and uncontrolled diabetes.	[ { "ade": "weight gain", "drug": "olanzapine" }, { "ade": "uncontrolled diabetes", "drug": "olanzapine" } ]
Acute coronary syndromes complicating the first infusion of rituximab.	[ { "ade": "Acute coronary syndromes", "drug": "rituximab" } ]
CONCLUSIONS: Priapism is an uncommon but potentially serious adverse effect of zuclopenthixol that practitioners, as with many other antipsychotics, should be aware of.	[ { "ade": "Priapism", "drug": "zuclopenthixol" } ]
A 5-month-old infant became lethargic and poorly responsive after receiving 1 drop of brimonidine in each eye.	[ { "ade": "lethargic", "drug": "brimonidine" }, { "ade": "poorly responsive", "drug": "brimonidine" } ]
In case no. 2, the pathogenic mechanism seemed to be persistent light reaction preceded by systemic photoallergy, as he had taken mequitazine for 6 months, and there were strong positive photopatch test results with immediate erythema reaction, cross-reaction to promethazine, decreased MED to both UVA and UVB, and persistence of the photosensitivity over a 3-year follow-up period after discontinuation of the mequitazine.	[ { "ade": "persistence of the photosensitivity", "drug": "promethazine" }, { "ade": "cross-reaction to promethazine", "drug": "promethazine" }, { "ade": "erythema", "drug": "promethazine" }, { "ade": "cross-reaction to promethazine", "drug": "mequitazine" }, { "ade": "persistence of the photosensitivity", "drug": "mequitazine" }, { "ade": "erythema", "drug": "mequitazine" }, { "ade": "decreased MED to both UVA and UVB", "drug": "mequitazine" }, { "ade": "decreased MED to both UVA and UVB", "drug": "promethazine" } ]
Ovarian endometrioid carcinoma and endometriosis developing in a postmenopausal breast cancer patient during tamoxifen therapy: a case report and review of the literature.	[ { "ade": "endometriosis", "drug": "tamoxifen" }, { "ade": "Ovarian endometrioid carcinoma", "drug": "tamoxifen" } ]
We observed transient panhypogammaglobulinaemia in a patient with neuropsychiatric SLE after treatment with prednisolone and cyclophosphamide.	[ { "ade": "panhypogammaglobulinaemia", "drug": "prednisolone" }, { "ade": "panhypogammaglobulinaemia", "drug": "cyclophosphamide" } ]
Insulin-induced lipohypertrophy: report of a case with histopathology.	[ { "ade": "lipohypertrophy", "drug": "Insulin" } ]
Prenatal cytomegalovirus (CMV) infection associated with severe brain damage was detected in an infant whose mother had been treated with prednisolone and azathioprine for systemic lupus erythematosus (SLE).	[ { "ade": "Prenatal cytomegalovirus (CMV) infection", "drug": "azathioprine" }, { "ade": "brain damage", "drug": "azathioprine" }, { "ade": "Prenatal cytomegalovirus (CMV) infection", "drug": "prednisolone" }, { "ade": "brain damage", "drug": "prednisolone" } ]
A 27-year-old man who had a history of bronchial asthma, eosinophilic enteritis, and eosinophilic pneumonia presented with fever, skin eruptions, cervical lymphadenopathy, hepatosplenomegaly, atypical lymphocytosis, and eosinophilia two weeks after receiving trimethoprim (TMP)-sulfamethoxazole (SMX) treatment.	[ { "ade": "cervical lymphadenopathy", "drug": "SMX" }, { "ade": "cervical lymphadenopathy", "drug": "sulfamethoxazole" }, { "ade": "hepatosplenomegaly", "drug": "SMX" }, { "ade": "skin eruptions", "drug": "trimethoprim" }, { "ade": "hepatosplenomegaly", "drug": "trimethoprim" }, { "ade": "atypical lymphocytosis", "drug": "sulfamethoxazole" }, { "ade": "eosinophilia", "drug": "TMP" }, { "ade": "eosinophilia", "drug": "SMX" }, { "ade": "cervical lymphadenopathy", "drug": "trimethoprim" }, { "ade": "fever", "drug": "SMX" }, { "ade": "eosinophilia", "drug": "trimethoprim" }, { "ade": "skin eruptions", "drug": "SMX" }, { "ade": "hepatosplenomegaly", "drug": "sulfamethoxazole" }, { "ade": "fever", "drug": "sulfamethoxazole" }, { "ade": "eosinophilia", "drug": "sulfamethoxazole" }, { "ade": "atypical lymphocytosis", "drug": "SMX" }, { "ade": "atypical lymphocytosis", "drug": "TMP" }, { "ade": "skin eruptions", "drug": "sulfamethoxazole" }, { "ade": "fever", "drug": "TMP" }, { "ade": "fever", "drug": "trimethoprim" }, { "ade": "cervical lymphadenopathy", "drug": "TMP" }, { "ade": "skin eruptions", "drug": "TMP" }, { "ade": "atypical lymphocytosis", "drug": "trimethoprim" }, { "ade": "hepatosplenomegaly", "drug": "TMP" } ]
A lethal complication of peripheral vein vasopressin infusion.	[ { "ade": "lethal complication", "drug": "vasopressin" } ]
Rebound hyperglycemia was observed with both intermediate (neutral protamine hagedorn) and long-acting (protamine zinc iletin) insulins, and the range of insulin doses at which the disorder developed overlapped previously determined therapeutic doses for these insulins in the cat.	[ { "ade": "Rebound hyperglycemia", "drug": "protamine hagedorn" }, { "ade": "Rebound hyperglycemia", "drug": "protamine zinc iletin" } ]
After 5-ASA was discontinued, the polyneuropathy symptoms recovered gradually.	[ { "ade": "polyneuropathy", "drug": "5-ASA" } ]
A 35-year-old female with borderline lepromatous (BL) leprosy who suffered from dapsone-induced erythroderma is reported.	[ { "ade": "erythroderma", "drug": "dapsone" } ]
Vitiligo associated with alpha-interferon in a patient with chronic active hepatitis C.	[ { "ade": "Vitiligo", "drug": "alpha-interferon" } ]
Early peritoneal dialysis has not previously been reported for lisinopril induced multiorgan failure.	[ { "ade": "multiorgan failure", "drug": "lisinopril" } ]
We report a case of reversible DKA and new-onset DM that developed in a demented patient who was treated with quetiapine for 14 days.	[ { "ade": "DKA", "drug": "quetiapine" }, { "ade": "DM", "drug": "quetiapine" } ]
Vocal cord paralysis as a consequence of peritonsillar infiltration with bupivacaine.	[ { "ade": "Vocal cord paralysis", "drug": "bupivacaine" } ]
The second patient exhibited sudden PLMS following olanzapine injection.	[ { "ade": "PLMS", "drug": "olanzapine" } ]
An unusual presentation of spontaneous sub-conjunctival haematoma in a patient receiving warfarin.	[ { "ade": "sub-conjunctival haematoma", "drug": "warfarin" } ]
A healthy, 30-year-old man, exposed to sulindac on two separate occasions, had an incapacitating isolated idential sensory neuropathy.	[ { "ade": "isolated idential sensory neuropathy", "drug": "sulindac" } ]
The pathogenic mechanisms involved in the development of adriamycin cardiomyopathy are reviewed, and the possible synergistic effect of other antitumor antibiotics is discussed.	[ { "ade": "cardiomyopathy", "drug": "adriamycin" } ]
RESULTS: A previously healthy 42-year-old woman presented with acute-onset delirium with psychotic features as a consequence of levofloxacin therapy.	[ { "ade": "acute-onset delirium with psychotic features", "drug": "levofloxacin" } ]
Bilateral acoustic (VIII) nerve palsy in this patient was most likely a manifestation of vincristine neurotoxicity.	[ { "ade": "neurotoxicity", "drug": "vincristine" }, { "ade": "Bilateral acoustic (VIII) nerve palsy", "drug": "vincristine" } ]
We report 3 children with epilepsy who developed facial motor tics after initiation of CBZ for complex partial seizures.	[ { "ade": "facial motor tics", "drug": "CBZ" } ]
Alprazolam withdrawal delirium unresponsive to diazepam: case report.	[ { "ade": "delirium", "drug": "Alprazolam" } ]

1. Changes in the plasma cortisol level were reported in a male patient with panic disorder during the period of low-dose alprazolam treatment (mean 0.62 +/- 0.15 mg/day) compared with during the period of high-dose period (mean 1.08 +/- 0.28 mg/day).

[ { "ade": "Changes in the plasma cortisol level", "drug": "alprazolam" } ]

The temporal sequence of the respiratory insufficiency and the histopathology, when compared to the previous examples in the literature, suggest that cyclophosphamide was aetiologically responsible for the lung disease.

[ { "ade": "lung disease", "drug": "cyclophosphamide" }, { "ade": "respiratory insufficiency", "drug": "cyclophosphamide" } ]

Its overall toxicity is considerably less compared to standard induction chemotherapy; however, it is associated with a high incidence of a potentially fatal symptom complex referred to as "retinoic acid syndrome." This report describes a patient with APL who developed the syndrome a few weeks after initiating induction therapy with ATRA despite being treated for hyperleukocytosis.

[ { "ade": "potentially fatal symptom", "drug": "retinoic acid" }, { "ade": "retinoic acid syndrome", "drug": "retinoic acid" }, { "ade": "toxicity", "drug": "retinoic acid" } ]

Cessation of D-Pen and the start of corticosteroid therapy were followed by recovery from bicytopenia.

[ { "ade": "bicytopenia", "drug": "D-Pen" } ]

Colchicine-induced myopathy in a teenager with familial Mediterranean fever.

[ { "ade": "myopathy", "drug": "Colchicine" } ]

Goiter and hypothyroidism during re-treatment with amiodarone in a patient who previously experienced amiodarone-induced thyrotoxicosis.

[ { "ade": "thyrotoxicosis", "drug": "amiodarone" }, { "ade": "hypothyroidism", "drug": "amiodarone" }, { "ade": "Goiter", "drug": "amiodarone" } ]

Hair loss associated with paroxetine treatment: a case report.

[ { "ade": "Hair loss", "drug": "paroxetine" } ]

Methotrexate-induced hepatic necrosis requiring liver transplantation in a patient with rheumatoid arthritis.

[ { "ade": "hepatic necrosis", "drug": "Methotrexate" } ]

Successful treatment of hyperthyroidism with amiodarone in a patient with propylthiouracil-induced acute hepatic failure.

[ { "ade": "acute hepatic failure", "drug": "propylthiouracil" } ]

We report an unusual case of simultaneous transitional cell carcinoma of the renal pelvis and distal ureter without transitional cell carcinoma of the bladder occurring after chronic cyclophosphamide therapy for nonHodgkin's lymphoma.

[ { "ade": "transitional cell carcinoma of the renal pelvis", "drug": "cyclophosphamide" }, { "ade": "distal ureter without transitional cell carcinoma of the bladder", "drug": "cyclophosphamide" } ]

We report a case of secondary glaucoma caused by epithelial downgrowth in which filtration surgery was performed with adjunctive use of subconjunctival 5-fluorouracil.

[ { "ade": "glaucoma", "drug": "5-fluorouracil" } ]

The patient described feeling cold with worsening headache and chills approximately one hour after infusion of the first dose of penicillin.

[ { "ade": "worsening headache", "drug": "penicillin" }, { "ade": "feeling cold", "drug": "penicillin" }, { "ade": "chills", "drug": "penicillin" } ]

OBSERVATIONS: A 48-year-old woman presented with disfiguring facial edema 10 weeks after she began antiviral therapy with peginterferon alfa-2a and ribavirin for chronic hepatitis C infection.

[ { "ade": "disfiguring facial edema", "drug": "ribavirin" }, { "ade": "disfiguring facial edema", "drug": "peginterferon alfa-2a" } ]

This is the first description, to our knowledge, of ductopenia apparently caused by clindamycin.

[ { "ade": "ductopenia", "drug": "clindamycin" } ]

Visual hallucinations associated with zonisamide.

[ { "ade": "Visual hallucinations", "drug": "zonisamide" } ]

Severe loss of vision after removal of cataract caused by intravitreal triamcinolone in combination with photodynamic therapy for exudative age-related macular degeneration.

[ { "ade": "Severe loss of vision", "drug": "triamcinolone" }, { "ade": "cataract", "drug": "triamcinolone" } ]

There was a clear relationship between restarting the Accutane and recurrence of the transient myopia.

[ { "ade": "transient myopia", "drug": "Accutane" } ]

The purpose of this article is to present the first case-series of posterior reversible encephalopathy syndrome (PRES) associated with L-asparaginase treatment.

[ { "ade": "PRES", "drug": "L-asparaginase" }, { "ade": "posterior reversible encephalopathy syndrome", "drug": "L-asparaginase" } ]

A 36-y-o patient with schizophrenia, who had consumed gradually increasing quantities of oolong tea that eventually reached 15 L each day, became delirious and was admitted to a psychiatric hospital.

[ { "ade": "delirious", "drug": "oolong tea" } ]

Acute kidney injury caused by zonisamide-induced hypersensitivity syndrome.

[ { "ade": "Acute kidney injury", "drug": "zonisamide" }, { "ade": "hypersensitivity syndrome", "drug": "zonisamide" } ]

Cardiomyopathy after widely separated courses of adriamycin exacerbated by actinomycin-D and mithramycin.

[ { "ade": "Cardiomyopathy", "drug": "adriamycin" }, { "ade": "Cardiomyopathy", "drug": "mithramycin" }, { "ade": "Cardiomyopathy", "drug": "actinomycin-D" } ]

Albeit rare among Western patients, such lithium-associated thyroid dysfunctions appeared to be more likely to occur in Hong Kong Chinese.

[ { "ade": "thyroid dysfunctions", "drug": "lithium" } ]

We report a case of severe hypotension associated with intravenous valproate used to treat status epilepticus in an 11-year-old girl.

[ { "ade": "hypotension", "drug": "valproate" } ]

Generalised pustular psoriasis induced by cyclosporin a withdrawal responding to the tumour necrosis factor alpha inhibitor etanercept.

[ { "ade": "Generalised pustular psoriasis", "drug": "cyclosporin a" } ]

The ocular toxicity of DCF, previously described as conjunctivitis, appears to be a keratitis of moderate severity which requires further study.

[ { "ade": "keratitis", "drug": "DCF" }, { "ade": "conjunctivitis", "drug": "DCF" }, { "ade": "ocular toxicity", "drug": "DCF" } ]

This case is remarkable since 1) ECM developed after subcutaneous and not after intramuscular injection, 2) the injection was given by the patient himself, and 3) glatiramer acetate can induce skin necrosis as a side effect.

[ { "ade": "skin necrosis", "drug": "glatiramer acetate" } ]

We report the successful treatment of heparin-induced thrombocytopenia and subsequent hemorrhagic complications postoperatively in a 2-year-old child with Danaparoid (orgaran).

[ { "ade": "hemorrhagic complications", "drug": "heparin" }, { "ade": "thrombocytopenia", "drug": "heparin" } ]

Gynecomastia in epileptics treated with phenobarbital, phenytoin and fluoresone: two case reports.

[ { "ade": "Gynecomastia", "drug": "phenobarbital" }, { "ade": "Gynecomastia", "drug": "fluoresone" }, { "ade": "Gynecomastia", "drug": "phenytoin" } ]

There have been only two reports of cimetidine-induced hepatitis.

[ { "ade": "hepatitis", "drug": "cimetidine" } ]

Fixed drug eruption in hands caused by omeprazole.

[ { "ade": "eruption", "drug": "omeprazole" } ]

The authors conclude that among patients taking high doses of oral niacin only those who experience visual symptoms need to be ophthalmologically evaluated.

[ { "ade": "visual symptoms", "drug": "niacin" } ]

HUS has been reported after several anticancer chemotherapies and most often after mitomycin C-based chemotherapy regimens.

[ { "ade": "HUS", "drug": "mitomycin C" } ]

A drug interaction between zafirlukast and theophylline.

[ { "ade": "drug interaction", "drug": "zafirlukast" }, { "ade": "drug interaction", "drug": "theophylline" } ]

Animals treated with HAL showed a highly significant 32%-46% loss of tyrosine hydroxylase (TH) immunoreactive neurons in the substantia nigra, and 20% contraction of the TH stained dendritic arbour.

[ { "ade": "significant 32%-46% loss of tyrosine hydroxylase (TH) immunoreactive neurons", "drug": "HAL" } ]

After extensive neurological 'work up', we realized that the anisocoria was related to the transdermal scopolamine patch that we had prescribed for weaning off the opioid.

[ { "ade": "anisocoria", "drug": "scopolamine" } ]

Cephalexin rash in infectious mononucleosis.

[ { "ade": "Cephalexin rash", "drug": "Cephalexin" } ]

Propylthiouracil-induced sensorineural hearing loss associated with antineutrophil cytoplasmic antibodies.

[ { "ade": "sensorineural hearing loss", "drug": "Propylthiouracil" }, { "ade": "antineutrophil cytoplasmic antibodies", "drug": "Propylthiouracil" } ]

Favorable outcome of de novo hepatitis B infection after liver transplantation with lamivudine and adefovir therapy.

[ { "ade": "hepatitis B infection", "drug": "adefovir" }, { "ade": "hepatitis B infection", "drug": "lamivudine" } ]

We report a case of drug-induced pemphigus caused by an angiotensin-converting enzyme inhibitor, captopril.

[ { "ade": "pemphigus", "drug": "captopril" } ]

Reactivation of cytomegalovirus probably followed the treatment of Wegener's granulomatosis with corticosteroids and azathioprine.

[ { "ade": "Reactivation of cytomegalovirus", "drug": "azathioprine" } ]

In addition to its known effect on gallbladder stasis, octreotide alters bile acid composition and may thus hasten intrahepatic sludge and stone formation.

[ { "ade": "alters bile acid composition", "drug": "octreotide" }, { "ade": "stone formation", "drug": "octreotide" }, { "ade": "gallbladder stasis", "drug": "octreotide" }, { "ade": "hasten intrahepatic sludge", "drug": "octreotide" } ]

Two patients who were receiving Tolazoline by infusion developed duodenal ulceration and subsequent intestinal perforation.

[ { "ade": "duodenal ulceration", "drug": "Tolazoline" }, { "ade": "intestinal perforation", "drug": "Tolazoline" } ]

Cardiac arrest following use of sumatriptan.

[ { "ade": "Cardiac arrest", "drug": "sumatriptan" } ]

To our knowledge , this is the first reported case of bromide intoxication due to pyridostigmine bromide administration.

[ { "ade": "bromide intoxication", "drug": "pyridostigmine bromide" } ]

All developed mucocutaneous side effects within 20 weeks of beginning im gold therapy, at a time when RA had improved markedly compared to pretreatment status.

[ { "ade": "mucocutaneous side effects", "drug": "gold" } ]

Acute vision loss after intravitreal injection of bevacizumab (avastin) associated with ocular ischemic syndrome.

[ { "ade": "Acute vision loss", "drug": "bevacizumab" }, { "ade": "ocular ischemic syndrome", "drug": "bevacizumab" }, { "ade": "ocular ischemic syndrome", "drug": "avastin" }, { "ade": "Acute vision loss", "drug": "avastin" } ]

Life-threatening alterations in heart rate after the use of adenosine in atrial flutter.

[ { "ade": "alterations in heart rate", "drug": "adenosine" } ]

Toxic epidermal necrolysis after the use of high-dose cytosine arabinoside.

[ { "ade": "Toxic epidermal necrolysis", "drug": "cytosine arabinoside" } ]

We describe a patient with transitional cell carcinoma of the renal pelvis who developed respiratory dysfunction and an abnormal chest x-ray with diffuse interstitial opacities while on chemotherapy with piritrexim, a methotrexate analog.

[ { "ade": "abnormal chest x-ray with diffuse interstitial opacities", "drug": "piritrexim" }, { "ade": "respiratory dysfunction", "drug": "piritrexim" } ]

Acute hemorrhagic gastritis associated with acetazolamide intoxication in a patient with chronic renal failure.

[ { "ade": "acetazolamide intoxication", "drug": "acetazolamide" }, { "ade": "Acute hemorrhagic gastritis", "drug": "acetazolamide" } ]

A patient developed transient, acute myopia while on isotretinoin (Accutane) therapy for acne.

[ { "ade": "acute myopia", "drug": "isotretinoin" }, { "ade": "acute myopia", "drug": "Accutane" } ]

This increase when clozapine was switched to risperidone and vice versa is consistent with our previous report of elevated serum triglyceride levels in clozapine-treated patients.

[ { "ade": "elevated serum triglyceride levels", "drug": "clozapine" } ]

We report a case of noncardiogenic pulmonary edema developed after therapeutic trial of EO as sclerosing agent for esophageal varix.

[ { "ade": "noncardiogenic pulmonary edema", "drug": "EO" } ]

The temporal relationship suggests that the spinal cord infarction may be related to the use of zolmitriptan.

[ { "ade": "spinal cord infarction", "drug": "zolmitriptan" } ]

There is a putative role of liothyronine administration in precipitating or activating hyperthyroidism.

[ { "ade": "hyperthyroidism", "drug": "liothyronine" } ]

CASE: We report a case of a woman with severe human insulin-induced lipoatrophy who has been treated exclusively with recombinant DNA human insulin since the onset of IDDM.

[ { "ade": "lipoatrophy", "drug": "human insulin" }, { "ade": "lipoatrophy", "drug": "recombinant DNA human insulin" } ]

Phenytoin toxicity: an easily missed cause of cerebellar syndrome.

[ { "ade": "cerebellar syndrome", "drug": "Phenytoin" } ]

Myoclonus was induced and enhanced by L-dopa, developing into generalized seizures.

[ { "ade": "Myoclonus", "drug": "L-dopa" }, { "ade": "generalized seizures", "drug": "L-dopa" } ]

Possible mechanisms for damage to the urothelium by ketamine are suggested.

[ { "ade": "damage to the urothelium", "drug": "ketamine" } ]

Successful challenge with clozapine in a history of eosinophilia.

[ { "ade": "eosinophilia", "drug": "clozapine" } ]

The pro-arrhythmic effects of procainamide may be explained on the basis of both its vagolytic action on the atrioventricular node as well as by prolongation of refractoriness in the accessory pathway.

[ { "ade": "pro-arrhythmic effects", "drug": "procainamide" } ]

Bone marrow aplasia and severe skin rash after a single low dose of methotrexate.

[ { "ade": "severe skin rash", "drug": "methotrexate" }, { "ade": "Bone marrow aplasia", "drug": "methotrexate" } ]

We describe a case of a man treated with an EGFR-inhibitor (erlotinib) for a cell lung cancer who developed skin manifestations localized in an uncommon area and with an atypical evolution.

[ { "ade": "skin manifestations", "drug": "erlotinib" } ]

We present a case of a diabetic patient taking glyburide who was prescribed ciprofloxacin and developed prolonged hypoglycemia, which persisted for over 24 hours.

[ { "ade": "prolonged hypoglycemia", "drug": "ciprofloxacin" }, { "ade": "prolonged hypoglycemia", "drug": "glyburide" } ]

CASE SUMMARY: A 68-year-old woman developed a dry, irritating cough within one month of starting quinapril therapy for the treatment of essential hypertension.

[ { "ade": "irritating cough", "drug": "quinapril" } ]

DISCUSSION: Rhabdomyolysis is a clinical syndrome resulting from the destruction of skeletal muscle that may progress to renal failure Several drugs have been associated with rhabdomyolysis, including lovastatin, a hydroxymethylglutaryl-coenzyme A reductase inhibitor.

[ { "ade": "rhabdomyolysis", "drug": "lovastatin" } ]

A patient with coccidioidal meningitis was treated with intrathecally administered amphotericin B, and an acute toxic delirium with EEG abnormalities developed.

[ { "ade": "EEG abnormalities", "drug": "amphotericin B" }, { "ade": "acute toxic delirium", "drug": "amphotericin B" } ]

Severe acidosis from acetazolamide in a diabetic patient.

[ { "ade": "Severe acidosis", "drug": "acetazolamide" } ]

We report three cases of patients who developed leukopenia during olanzapine treatment.

[ { "ade": "leukopenia", "drug": "olanzapine" } ]

We report a case of Ritalin-associated cataract and glaucoma.

[ { "ade": "cataract", "drug": "Ritalin" }, { "ade": "glaucoma", "drug": "Ritalin" } ]

OBJECTIVE: To our knowledge, this is the first published case report of an adolescent girl with a mitochondrial disorder and depression who displayed both new-onset psychotic and increased mood symptoms during treatment with risperidone.

[ { "ade": "increased mood symptoms", "drug": "risperidone" } ]

CONCLUSION: The present findings suggest that: (i) amantadine probably exerts its anti-dyskinetic effect by acting on the "indirect" pathway; (ii) the pathophysiological mechanisms of subthalamotomy induced dyskinesias may differ from those involved in L-dopa induced dyskinesias; (iii) dyskinesias induced by STN surgery resolve spontaneously as compensatory mechanisms develop.

[ { "ade": "dyskinesias", "drug": "L-dopa" } ]

The intramuscular challenge test with 25 UI of Miacalcic was positive with an immediate anaphylactic reaction.

[ { "ade": "anaphylactic reaction", "drug": "Miacalcic" } ]

Atrial fibrillation after vardenafil therapy.

[ { "ade": "Atrial fibrillation", "drug": "vardenafil" } ]

The patient was enrolled in a weight-loss clinic, and his diabetes medications were adjusted.Subsequently, olanzapine was discontinued because of weight gain and uncontrolled diabetes.

[ { "ade": "weight gain", "drug": "olanzapine" }, { "ade": "uncontrolled diabetes", "drug": "olanzapine" } ]

Acute coronary syndromes complicating the first infusion of rituximab.

[ { "ade": "Acute coronary syndromes", "drug": "rituximab" } ]

CONCLUSIONS: Priapism is an uncommon but potentially serious adverse effect of zuclopenthixol that practitioners, as with many other antipsychotics, should be aware of.

[ { "ade": "Priapism", "drug": "zuclopenthixol" } ]

A 5-month-old infant became lethargic and poorly responsive after receiving 1 drop of brimonidine in each eye.

[ { "ade": "lethargic", "drug": "brimonidine" }, { "ade": "poorly responsive", "drug": "brimonidine" } ]

In case no. 2, the pathogenic mechanism seemed to be persistent light reaction preceded by systemic photoallergy, as he had taken mequitazine for 6 months, and there were strong positive photopatch test results with immediate erythema reaction, cross-reaction to promethazine, decreased MED to both UVA and UVB, and persistence of the photosensitivity over a 3-year follow-up period after discontinuation of the mequitazine.

[ { "ade": "persistence of the photosensitivity", "drug": "promethazine" }, { "ade": "cross-reaction to promethazine", "drug": "promethazine" }, { "ade": "erythema", "drug": "promethazine" }, { "ade": "cross-reaction to promethazine", "drug": "mequitazine" }, { "ade": "persistence of the photosensitivity", "drug": "mequitazine" }, { "ade": "erythema", "drug": "mequitazine" }, { "ade": "decreased MED to both UVA and UVB", "drug": "mequitazine" }, { "ade": "decreased MED to both UVA and UVB", "drug": "promethazine" } ]

Ovarian endometrioid carcinoma and endometriosis developing in a postmenopausal breast cancer patient during tamoxifen therapy: a case report and review of the literature.

[ { "ade": "endometriosis", "drug": "tamoxifen" }, { "ade": "Ovarian endometrioid carcinoma", "drug": "tamoxifen" } ]

We observed transient panhypogammaglobulinaemia in a patient with neuropsychiatric SLE after treatment with prednisolone and cyclophosphamide.

[ { "ade": "panhypogammaglobulinaemia", "drug": "prednisolone" }, { "ade": "panhypogammaglobulinaemia", "drug": "cyclophosphamide" } ]

Insulin-induced lipohypertrophy: report of a case with histopathology.

[ { "ade": "lipohypertrophy", "drug": "Insulin" } ]

Prenatal cytomegalovirus (CMV) infection associated with severe brain damage was detected in an infant whose mother had been treated with prednisolone and azathioprine for systemic lupus erythematosus (SLE).

[ { "ade": "Prenatal cytomegalovirus (CMV) infection", "drug": "azathioprine" }, { "ade": "brain damage", "drug": "azathioprine" }, { "ade": "Prenatal cytomegalovirus (CMV) infection", "drug": "prednisolone" }, { "ade": "brain damage", "drug": "prednisolone" } ]

A 27-year-old man who had a history of bronchial asthma, eosinophilic enteritis, and eosinophilic pneumonia presented with fever, skin eruptions, cervical lymphadenopathy, hepatosplenomegaly, atypical lymphocytosis, and eosinophilia two weeks after receiving trimethoprim (TMP)-sulfamethoxazole (SMX) treatment.

[ { "ade": "cervical lymphadenopathy", "drug": "SMX" }, { "ade": "cervical lymphadenopathy", "drug": "sulfamethoxazole" }, { "ade": "hepatosplenomegaly", "drug": "SMX" }, { "ade": "skin eruptions", "drug": "trimethoprim" }, { "ade": "hepatosplenomegaly", "drug": "trimethoprim" }, { "ade": "atypical lymphocytosis", "drug": "sulfamethoxazole" }, { "ade": "eosinophilia", "drug": "TMP" }, { "ade": "eosinophilia", "drug": "SMX" }, { "ade": "cervical lymphadenopathy", "drug": "trimethoprim" }, { "ade": "fever", "drug": "SMX" }, { "ade": "eosinophilia", "drug": "trimethoprim" }, { "ade": "skin eruptions", "drug": "SMX" }, { "ade": "hepatosplenomegaly", "drug": "sulfamethoxazole" }, { "ade": "fever", "drug": "sulfamethoxazole" }, { "ade": "eosinophilia", "drug": "sulfamethoxazole" }, { "ade": "atypical lymphocytosis", "drug": "SMX" }, { "ade": "atypical lymphocytosis", "drug": "TMP" }, { "ade": "skin eruptions", "drug": "sulfamethoxazole" }, { "ade": "fever", "drug": "TMP" }, { "ade": "fever", "drug": "trimethoprim" }, { "ade": "cervical lymphadenopathy", "drug": "TMP" }, { "ade": "skin eruptions", "drug": "TMP" }, { "ade": "atypical lymphocytosis", "drug": "trimethoprim" }, { "ade": "hepatosplenomegaly", "drug": "TMP" } ]

A lethal complication of peripheral vein vasopressin infusion.

[ { "ade": "lethal complication", "drug": "vasopressin" } ]

Rebound hyperglycemia was observed with both intermediate (neutral protamine hagedorn) and long-acting (protamine zinc iletin) insulins, and the range of insulin doses at which the disorder developed overlapped previously determined therapeutic doses for these insulins in the cat.

[ { "ade": "Rebound hyperglycemia", "drug": "protamine hagedorn" }, { "ade": "Rebound hyperglycemia", "drug": "protamine zinc iletin" } ]

After 5-ASA was discontinued, the polyneuropathy symptoms recovered gradually.

[ { "ade": "polyneuropathy", "drug": "5-ASA" } ]

A 35-year-old female with borderline lepromatous (BL) leprosy who suffered from dapsone-induced erythroderma is reported.

[ { "ade": "erythroderma", "drug": "dapsone" } ]

Vitiligo associated with alpha-interferon in a patient with chronic active hepatitis C.

[ { "ade": "Vitiligo", "drug": "alpha-interferon" } ]

Early peritoneal dialysis has not previously been reported for lisinopril induced multiorgan failure.

[ { "ade": "multiorgan failure", "drug": "lisinopril" } ]

We report a case of reversible DKA and new-onset DM that developed in a demented patient who was treated with quetiapine for 14 days.

[ { "ade": "DKA", "drug": "quetiapine" }, { "ade": "DM", "drug": "quetiapine" } ]

Vocal cord paralysis as a consequence of peritonsillar infiltration with bupivacaine.

[ { "ade": "Vocal cord paralysis", "drug": "bupivacaine" } ]

The second patient exhibited sudden PLMS following olanzapine injection.

[ { "ade": "PLMS", "drug": "olanzapine" } ]

An unusual presentation of spontaneous sub-conjunctival haematoma in a patient receiving warfarin.

[ { "ade": "sub-conjunctival haematoma", "drug": "warfarin" } ]

A healthy, 30-year-old man, exposed to sulindac on two separate occasions, had an incapacitating isolated idential sensory neuropathy.

[ { "ade": "isolated idential sensory neuropathy", "drug": "sulindac" } ]

The pathogenic mechanisms involved in the development of adriamycin cardiomyopathy are reviewed, and the possible synergistic effect of other antitumor antibiotics is discussed.

[ { "ade": "cardiomyopathy", "drug": "adriamycin" } ]

RESULTS: A previously healthy 42-year-old woman presented with acute-onset delirium with psychotic features as a consequence of levofloxacin therapy.

[ { "ade": "acute-onset delirium with psychotic features", "drug": "levofloxacin" } ]

Bilateral acoustic (VIII) nerve palsy in this patient was most likely a manifestation of vincristine neurotoxicity.

[ { "ade": "neurotoxicity", "drug": "vincristine" }, { "ade": "Bilateral acoustic (VIII) nerve palsy", "drug": "vincristine" } ]

We report 3 children with epilepsy who developed facial motor tics after initiation of CBZ for complex partial seizures.

[ { "ade": "facial motor tics", "drug": "CBZ" } ]

Alprazolam withdrawal delirium unresponsive to diazepam: case report.

[ { "ade": "delirium", "drug": "Alprazolam" } ]