broad_id
string | depmap_id
string | ccle_name
string | screen_id
string | upper_limit
int64 | lower_limit
float64 | slope
float64 | r2
float64 | auc
float64 | ec50
float64 | ic50
float64 | name
string | moa
string | target
string | disease.area
string | indication
string | smiles
string | phase
string | passed_str_profiling
bool | row_name
string |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
BRD-K72951360-001-01-4 | ACH-000445 | KNS60_CENTRAL_NERVOUS_SYSTEM | HTS002 | 1 | 0.000433 | 5.635753 | 0.616212 | 0.679512 | 0.445391 | 0.445459 | valrubicin | DNA inhibitor, topoisomerase inhibitor | TOP2A | oncology | bladder cancer | CCCCC(=O)OCC(=O)[C@@]1(O)C[C@H](O[C@H]2C[C@H](NC(=O)C(F)(F)F)[C@H](O)[C@H](C)O2)c2c(O)c3C(=O)c4c(OC)cccc4C(=O)c3c(O)c2C1 | Launched | true | ACH-000445 |
BRD-K72951360-001-01-4 | ACH-000331 | ISTMES2_PLEURA | HTS002 | 1 | 0.03724 | 7.114782 | 0.749412 | 0.676396 | 0.383216 | 0.387407 | valrubicin | DNA inhibitor, topoisomerase inhibitor | TOP2A | oncology | bladder cancer | CCCCC(=O)OCC(=O)[C@@]1(O)C[C@H](O[C@H]2C[C@H](NC(=O)C(F)(F)F)[C@H](O)[C@H](C)O2)c2c(O)c3C(=O)c4c(OC)cccc4C(=O)c3c(O)c2C1 | Launched | true | ACH-000331 |
BRD-K72951360-001-01-4 | ACH-000163 | SW579_THYROID | HTS002 | 1 | -0.003499 | 1.209626 | 0.414646 | 0.609674 | 0.228251 | 0.226939 | valrubicin | DNA inhibitor, topoisomerase inhibitor | TOP2A | oncology | bladder cancer | CCCCC(=O)OCC(=O)[C@@]1(O)C[C@H](O[C@H]2C[C@H](NC(=O)C(F)(F)F)[C@H](O)[C@H](C)O2)c2c(O)c3C(=O)c4c(OC)cccc4C(=O)c3c(O)c2C1 | Launched | true | ACH-000163 |
BRD-K72951360-001-01-4 | ACH-000768 | MDAMB231_BREAST | HTS002 | 1 | 0.012571 | 1.291715 | 0.66632 | 0.678471 | 0.429873 | 0.438431 | valrubicin | DNA inhibitor, topoisomerase inhibitor | TOP2A | oncology | bladder cancer | CCCCC(=O)OCC(=O)[C@@]1(O)C[C@H](O[C@H]2C[C@H](NC(=O)C(F)(F)F)[C@H](O)[C@H](C)O2)c2c(O)c3C(=O)c4c(OC)cccc4C(=O)c3c(O)c2C1 | Launched | true | ACH-000768 |
BRD-K72951360-001-01-4 | null | null | HTS002 | 1 | 0.016492 | 1.564835 | 0.805769 | 0.675106 | 0.407035 | 0.415854 | valrubicin | DNA inhibitor, topoisomerase inhibitor | TOP2A | oncology | bladder cancer | CCCCC(=O)OCC(=O)[C@@]1(O)C[C@H](O[C@H]2C[C@H](NC(=O)C(F)(F)F)[C@H](O)[C@H](C)O2)c2c(O)c3C(=O)c4c(OC)cccc4C(=O)c3c(O)c2C1 | Launched | false | ACH-001078_FAILED_STR |
BRD-K72951360-001-01-4 | ACH-000778 | HSC3_UPPER_AERODIGESTIVE_TRACT | HTS002 | 1 | 0.001349 | 1.705532 | 0.580083 | 0.588473 | 0.183471 | 0.183762 | valrubicin | DNA inhibitor, topoisomerase inhibitor | TOP2A | oncology | bladder cancer | CCCCC(=O)OCC(=O)[C@@]1(O)C[C@H](O[C@H]2C[C@H](NC(=O)C(F)(F)F)[C@H](O)[C@H](C)O2)c2c(O)c3C(=O)c4c(OC)cccc4C(=O)c3c(O)c2C1 | Launched | true | ACH-000778 |
BRD-K72951360-001-01-4 | ACH-000881 | MELJUSO_SKIN | HTS002 | 1 | 0.001931 | 1.063285 | 0.651744 | 0.612577 | 0.234878 | 0.235735 | valrubicin | DNA inhibitor, topoisomerase inhibitor | TOP2A | oncology | bladder cancer | CCCCC(=O)OCC(=O)[C@@]1(O)C[C@H](O[C@H]2C[C@H](NC(=O)C(F)(F)F)[C@H](O)[C@H](C)O2)c2c(O)c3C(=O)c4c(OC)cccc4C(=O)c3c(O)c2C1 | Launched | true | ACH-000881 |
BRD-K72951360-001-01-4 | ACH-000521 | NCIH2030_LUNG | HTS002 | 1 | 0.050249 | 5.420617 | 0.852505 | 0.569589 | 0.123054 | 0.125482 | valrubicin | DNA inhibitor, topoisomerase inhibitor | TOP2A | oncology | bladder cancer | CCCCC(=O)OCC(=O)[C@@]1(O)C[C@H](O[C@H]2C[C@H](NC(=O)C(F)(F)F)[C@H](O)[C@H](C)O2)c2c(O)c3C(=O)c4c(OC)cccc4C(=O)c3c(O)c2C1 | Launched | true | ACH-000521 |
BRD-K72951360-001-01-4 | ACH-000696 | OVCAR8_OVARY | HTS002 | 1 | 0.000351 | 1.412522 | 0.695603 | 0.662441 | 0.380073 | 0.380262 | valrubicin | DNA inhibitor, topoisomerase inhibitor | TOP2A | oncology | bladder cancer | CCCCC(=O)OCC(=O)[C@@]1(O)C[C@H](O[C@H]2C[C@H](NC(=O)C(F)(F)F)[C@H](O)[C@H](C)O2)c2c(O)c3C(=O)c4c(OC)cccc4C(=O)c3c(O)c2C1 | Launched | true | ACH-000696 |
BRD-K72951360-001-01-4 | ACH-000972 | HEC151_ENDOMETRIUM | HTS002 | 1 | 0.011092 | 8.616856 | 0.837143 | 0.575977 | 0.155934 | 0.156341 | valrubicin | DNA inhibitor, topoisomerase inhibitor | TOP2A | oncology | bladder cancer | CCCCC(=O)OCC(=O)[C@@]1(O)C[C@H](O[C@H]2C[C@H](NC(=O)C(F)(F)F)[C@H](O)[C@H](C)O2)c2c(O)c3C(=O)c4c(OC)cccc4C(=O)c3c(O)c2C1 | Launched | true | ACH-000972 |
BRD-K72951360-001-01-4 | ACH-000242 | RT4_URINARY_TRACT | HTS002 | 1 | 0.073968 | 1.633217 | 0.473758 | 0.645997 | 0.245198 | 0.27045 | valrubicin | DNA inhibitor, topoisomerase inhibitor | TOP2A | oncology | bladder cancer | CCCCC(=O)OCC(=O)[C@@]1(O)C[C@H](O[C@H]2C[C@H](NC(=O)C(F)(F)F)[C@H](O)[C@H](C)O2)c2c(O)c3C(=O)c4c(OC)cccc4C(=O)c3c(O)c2C1 | Launched | true | ACH-000242 |
BRD-K72951360-001-01-4 | ACH-000087 | SKES1_BONE | HTS002 | 1 | 0.027789 | 2.016132 | 0.642672 | 0.531873 | 0.093482 | 0.096172 | valrubicin | DNA inhibitor, topoisomerase inhibitor | TOP2A | oncology | bladder cancer | CCCCC(=O)OCC(=O)[C@@]1(O)C[C@H](O[C@H]2C[C@H](NC(=O)C(F)(F)F)[C@H](O)[C@H](C)O2)c2c(O)c3C(=O)c4c(OC)cccc4C(=O)c3c(O)c2C1 | Launched | true | ACH-000087 |
BRD-K72951360-001-01-4 | ACH-000926 | HT55_LARGE_INTESTINE | HTS002 | 1 | 0.157317 | 4.490776 | 0.614361 | 0.749969 | 0.561751 | 0.611055 | valrubicin | DNA inhibitor, topoisomerase inhibitor | TOP2A | oncology | bladder cancer | CCCCC(=O)OCC(=O)[C@@]1(O)C[C@H](O[C@H]2C[C@H](NC(=O)C(F)(F)F)[C@H](O)[C@H](C)O2)c2c(O)c3C(=O)c4c(OC)cccc4C(=O)c3c(O)c2C1 | Launched | true | ACH-000926 |
BRD-K72951360-001-01-4 | ACH-000356 | MKN45_STOMACH | HTS002 | 1 | 0.01541 | 11.557336 | 0.569946 | 0.707496 | 0.55972 | 0.561239 | valrubicin | DNA inhibitor, topoisomerase inhibitor | TOP2A | oncology | bladder cancer | CCCCC(=O)OCC(=O)[C@@]1(O)C[C@H](O[C@H]2C[C@H](NC(=O)C(F)(F)F)[C@H](O)[C@H](C)O2)c2c(O)c3C(=O)c4c(OC)cccc4C(=O)c3c(O)c2C1 | Launched | true | ACH-000356 |
BRD-K72951360-001-01-4 | ACH-000625 | HEP3B217_LIVER | HTS002 | 1 | 0.001018 | 1.134393 | 0.533933 | 0.620031 | 0.252615 | 0.253069 | valrubicin | DNA inhibitor, topoisomerase inhibitor | TOP2A | oncology | bladder cancer | CCCCC(=O)OCC(=O)[C@@]1(O)C[C@H](O[C@H]2C[C@H](NC(=O)C(F)(F)F)[C@H](O)[C@H](C)O2)c2c(O)c3C(=O)c4c(OC)cccc4C(=O)c3c(O)c2C1 | Launched | true | ACH-000625 |
BRD-K72951360-001-01-4 | ACH-000613 | HOS_BONE | HTS002 | 1 | 0.000033 | 5.962961 | 0.737067 | 0.551544 | 0.128811 | 0.128812 | valrubicin | DNA inhibitor, topoisomerase inhibitor | TOP2A | oncology | bladder cancer | CCCCC(=O)OCC(=O)[C@@]1(O)C[C@H](O[C@H]2C[C@H](NC(=O)C(F)(F)F)[C@H](O)[C@H](C)O2)c2c(O)c3C(=O)c4c(OC)cccc4C(=O)c3c(O)c2C1 | Launched | true | ACH-000613 |
BRD-K72951360-001-01-4 | ACH-000976 | HUCCT1_BILIARY_TRACT | HTS002 | 1 | 0.007146 | 1.841547 | 0.702774 | 0.702636 | 0.548124 | 0.552425 | valrubicin | DNA inhibitor, topoisomerase inhibitor | TOP2A | oncology | bladder cancer | CCCCC(=O)OCC(=O)[C@@]1(O)C[C@H](O[C@H]2C[C@H](NC(=O)C(F)(F)F)[C@H](O)[C@H](C)O2)c2c(O)c3C(=O)c4c(OC)cccc4C(=O)c3c(O)c2C1 | Launched | true | ACH-000976 |
BRD-K72951360-001-01-4 | ACH-001075 | NCIH292_LUNG | HTS002 | 1 | 0.018067 | 1.31394 | 0.650235 | 0.641614 | 0.291663 | 0.299948 | valrubicin | DNA inhibitor, topoisomerase inhibitor | TOP2A | oncology | bladder cancer | CCCCC(=O)OCC(=O)[C@@]1(O)C[C@H](O[C@H]2C[C@H](NC(=O)C(F)(F)F)[C@H](O)[C@H](C)O2)c2c(O)c3C(=O)c4c(OC)cccc4C(=O)c3c(O)c2C1 | Launched | true | ACH-001075 |
BRD-K72951360-001-01-4 | ACH-000261 | RERFLCAI_LUNG | HTS002 | 1 | 0.000338 | 1.813104 | 0.814881 | 0.519038 | 0.093834 | 0.093869 | valrubicin | DNA inhibitor, topoisomerase inhibitor | TOP2A | oncology | bladder cancer | CCCCC(=O)OCC(=O)[C@@]1(O)C[C@H](O[C@H]2C[C@H](NC(=O)C(F)(F)F)[C@H](O)[C@H](C)O2)c2c(O)c3C(=O)c4c(OC)cccc4C(=O)c3c(O)c2C1 | Launched | true | ACH-000261 |
BRD-K72951360-001-01-4 | ACH-000957 | LS180_LARGE_INTESTINE | HTS002 | 1 | 0.000201 | 18.298428 | 0.400853 | 0.847614 | 2.278512 | 2.278562 | valrubicin | DNA inhibitor, topoisomerase inhibitor | TOP2A | oncology | bladder cancer | CCCCC(=O)OCC(=O)[C@@]1(O)C[C@H](O[C@H]2C[C@H](NC(=O)C(F)(F)F)[C@H](O)[C@H](C)O2)c2c(O)c3C(=O)c4c(OC)cccc4C(=O)c3c(O)c2C1 | Launched | true | ACH-000957 |
BRD-K72951360-001-01-4 | ACH-000099 | SIMA_AUTONOMIC_GANGLIA | HTS002 | 1 | 0.050425 | 2.30478 | 0.570653 | 0.662602 | 0.31814 | 0.333157 | valrubicin | DNA inhibitor, topoisomerase inhibitor | TOP2A | oncology | bladder cancer | CCCCC(=O)OCC(=O)[C@@]1(O)C[C@H](O[C@H]2C[C@H](NC(=O)C(F)(F)F)[C@H](O)[C@H](C)O2)c2c(O)c3C(=O)c4c(OC)cccc4C(=O)c3c(O)c2C1 | Launched | true | ACH-000099 |
BRD-K72951360-001-01-4 | ACH-000783 | CAMA1_BREAST | HTS002 | 1 | 0.054171 | 12.577152 | 0.344188 | 0.788633 | 1.143375 | 1.153848 | valrubicin | DNA inhibitor, topoisomerase inhibitor | TOP2A | oncology | bladder cancer | CCCCC(=O)OCC(=O)[C@@]1(O)C[C@H](O[C@H]2C[C@H](NC(=O)C(F)(F)F)[C@H](O)[C@H](C)O2)c2c(O)c3C(=O)c4c(OC)cccc4C(=O)c3c(O)c2C1 | Launched | true | ACH-000783 |
BRD-K72951360-001-01-4 | ACH-000573 | MDAMB436_BREAST | HTS002 | 1 | 0.230104 | 1.306528 | 0.651735 | 0.675151 | 0.167161 | 0.26797 | valrubicin | DNA inhibitor, topoisomerase inhibitor | TOP2A | oncology | bladder cancer | CCCCC(=O)OCC(=O)[C@@]1(O)C[C@H](O[C@H]2C[C@H](NC(=O)C(F)(F)F)[C@H](O)[C@H](C)O2)c2c(O)c3C(=O)c4c(OC)cccc4C(=O)c3c(O)c2C1 | Launched | true | ACH-000573 |
BRD-K72951360-001-01-4 | ACH-000852 | NCIH1435_LUNG | HTS002 | 1 | 0.014578 | 1.418663 | 0.421899 | 0.770581 | 1.075209 | 1.097871 | valrubicin | DNA inhibitor, topoisomerase inhibitor | TOP2A | oncology | bladder cancer | CCCCC(=O)OCC(=O)[C@@]1(O)C[C@H](O[C@H]2C[C@H](NC(=O)C(F)(F)F)[C@H](O)[C@H](C)O2)c2c(O)c3C(=O)c4c(OC)cccc4C(=O)c3c(O)c2C1 | Launched | true | ACH-000852 |
BRD-K72951360-001-01-4 | ACH-000461 | SNU1196_BILIARY_TRACT | HTS002 | 1 | 0.02961 | 5.340583 | 0.392903 | 0.711531 | 0.558692 | 0.565115 | valrubicin | DNA inhibitor, topoisomerase inhibitor | TOP2A | oncology | bladder cancer | CCCCC(=O)OCC(=O)[C@@]1(O)C[C@H](O[C@H]2C[C@H](NC(=O)C(F)(F)F)[C@H](O)[C@H](C)O2)c2c(O)c3C(=O)c4c(OC)cccc4C(=O)c3c(O)c2C1 | Launched | true | ACH-000461 |
BRD-K72951360-001-01-4 | ACH-000420 | SNU449_LIVER | HTS002 | 1 | 0.12284 | 4.731814 | 0.807444 | 0.733419 | 0.523817 | 0.555976 | valrubicin | DNA inhibitor, topoisomerase inhibitor | TOP2A | oncology | bladder cancer | CCCCC(=O)OCC(=O)[C@@]1(O)C[C@H](O[C@H]2C[C@H](NC(=O)C(F)(F)F)[C@H](O)[C@H](C)O2)c2c(O)c3C(=O)c4c(OC)cccc4C(=O)c3c(O)c2C1 | Launched | true | ACH-000420 |
BRD-K72951360-001-01-4 | ACH-000694 | TE9_OESOPHAGUS | HTS002 | 1 | 0.078321 | 8.109831 | 0.565538 | 0.628204 | 0.199501 | 0.203736 | valrubicin | DNA inhibitor, topoisomerase inhibitor | TOP2A | oncology | bladder cancer | CCCCC(=O)OCC(=O)[C@@]1(O)C[C@H](O[C@H]2C[C@H](NC(=O)C(F)(F)F)[C@H](O)[C@H](C)O2)c2c(O)c3C(=O)c4c(OC)cccc4C(=O)c3c(O)c2C1 | Launched | true | ACH-000694 |
BRD-K72951360-001-01-4 | ACH-000528 | ABC1_LUNG | HTS002 | 1 | 0.000816 | 0.987503 | 0.765344 | 0.559976 | 0.140761 | 0.140994 | valrubicin | DNA inhibitor, topoisomerase inhibitor | TOP2A | oncology | bladder cancer | CCCCC(=O)OCC(=O)[C@@]1(O)C[C@H](O[C@H]2C[C@H](NC(=O)C(F)(F)F)[C@H](O)[C@H](C)O2)c2c(O)c3C(=O)c4c(OC)cccc4C(=O)c3c(O)c2C1 | Launched | true | ACH-000528 |
BRD-K72951360-001-01-4 | ACH-000845 | NCIH1373_LUNG | HTS002 | 1 | 0.002009 | 17.131158 | 0.49506 | 0.813997 | 1.638802 | 1.639188 | valrubicin | DNA inhibitor, topoisomerase inhibitor | TOP2A | oncology | bladder cancer | CCCCC(=O)OCC(=O)[C@@]1(O)C[C@H](O[C@H]2C[C@H](NC(=O)C(F)(F)F)[C@H](O)[C@H](C)O2)c2c(O)c3C(=O)c4c(OC)cccc4C(=O)c3c(O)c2C1 | Launched | true | ACH-000845 |
BRD-K72951360-001-01-4 | ACH-000563 | EBC1_LUNG | HTS002 | 1 | 0.019418 | 3.884055 | 0.686981 | 0.679716 | 0.420203 | 0.42451 | valrubicin | DNA inhibitor, topoisomerase inhibitor | TOP2A | oncology | bladder cancer | CCCCC(=O)OCC(=O)[C@@]1(O)C[C@H](O[C@H]2C[C@H](NC(=O)C(F)(F)F)[C@H](O)[C@H](C)O2)c2c(O)c3C(=O)c4c(OC)cccc4C(=O)c3c(O)c2C1 | Launched | true | ACH-000563 |
BRD-K72951360-001-01-4 | ACH-000665 | SKMES1_LUNG | HTS002 | 1 | 0.032153 | 1.776695 | 0.723699 | 0.632339 | 0.250834 | 0.260395 | valrubicin | DNA inhibitor, topoisomerase inhibitor | TOP2A | oncology | bladder cancer | CCCCC(=O)OCC(=O)[C@@]1(O)C[C@H](O[C@H]2C[C@H](NC(=O)C(F)(F)F)[C@H](O)[C@H](C)O2)c2c(O)c3C(=O)c4c(OC)cccc4C(=O)c3c(O)c2C1 | Launched | true | ACH-000665 |
BRD-K72951360-001-01-4 | ACH-000467 | HCC56_LARGE_INTESTINE | HTS002 | 1 | 0.098166 | 5.236892 | 0.567136 | 0.734372 | 0.573688 | 0.598138 | valrubicin | DNA inhibitor, topoisomerase inhibitor | TOP2A | oncology | bladder cancer | CCCCC(=O)OCC(=O)[C@@]1(O)C[C@H](O[C@H]2C[C@H](NC(=O)C(F)(F)F)[C@H](O)[C@H](C)O2)c2c(O)c3C(=O)c4c(OC)cccc4C(=O)c3c(O)c2C1 | Launched | true | ACH-000467 |
BRD-K72951360-001-01-4 | ACH-000201 | A204_SOFT_TISSUE | HTS002 | 1 | 0.005535 | 0.988957 | 0.782493 | 0.470027 | 0.056454 | 0.057093 | valrubicin | DNA inhibitor, topoisomerase inhibitor | TOP2A | oncology | bladder cancer | CCCCC(=O)OCC(=O)[C@@]1(O)C[C@H](O[C@H]2C[C@H](NC(=O)C(F)(F)F)[C@H](O)[C@H](C)O2)c2c(O)c3C(=O)c4c(OC)cccc4C(=O)c3c(O)c2C1 | Launched | true | ACH-000201 |
BRD-K72951360-001-01-4 | ACH-000296 | OUMS23_LARGE_INTESTINE | HTS002 | 1 | 0.025557 | 5.657231 | 0.42601 | 0.60995 | 0.205612 | 0.207528 | valrubicin | DNA inhibitor, topoisomerase inhibitor | TOP2A | oncology | bladder cancer | CCCCC(=O)OCC(=O)[C@@]1(O)C[C@H](O[C@H]2C[C@H](NC(=O)C(F)(F)F)[C@H](O)[C@H](C)O2)c2c(O)c3C(=O)c4c(OC)cccc4C(=O)c3c(O)c2C1 | Launched | true | ACH-000296 |
BRD-K72951360-001-01-4 | ACH-000189 | RCC10RGB_KIDNEY | HTS002 | 1 | 0.122292 | 5.080937 | 0.744147 | 0.732609 | 0.520098 | 0.549617 | valrubicin | DNA inhibitor, topoisomerase inhibitor | TOP2A | oncology | bladder cancer | CCCCC(=O)OCC(=O)[C@@]1(O)C[C@H](O[C@H]2C[C@H](NC(=O)C(F)(F)F)[C@H](O)[C@H](C)O2)c2c(O)c3C(=O)c4c(OC)cccc4C(=O)c3c(O)c2C1 | Launched | true | ACH-000189 |
BRD-K72951360-001-01-4 | ACH-000791 | RERFLCAD1_LUNG | HTS002 | 1 | -0.214251 | 0.758367 | 0.616229 | 0.778111 | 1.539809 | 0.962138 | valrubicin | DNA inhibitor, topoisomerase inhibitor | TOP2A | oncology | bladder cancer | CCCCC(=O)OCC(=O)[C@@]1(O)C[C@H](O[C@H]2C[C@H](NC(=O)C(F)(F)F)[C@H](O)[C@H](C)O2)c2c(O)c3C(=O)c4c(OC)cccc4C(=O)c3c(O)c2C1 | Launched | true | ACH-000791 |
BRD-K72951360-001-01-4 | ACH-000367 | NCIH226_LUNG | HTS002 | 1 | 0.001065 | 1.060192 | 0.664799 | 0.651506 | 0.347297 | 0.347997 | valrubicin | DNA inhibitor, topoisomerase inhibitor | TOP2A | oncology | bladder cancer | CCCCC(=O)OCC(=O)[C@@]1(O)C[C@H](O[C@H]2C[C@H](NC(=O)C(F)(F)F)[C@H](O)[C@H](C)O2)c2c(O)c3C(=O)c4c(OC)cccc4C(=O)c3c(O)c2C1 | Launched | true | ACH-000367 |
BRD-K72951360-001-01-4 | ACH-001190 | SKMEL2_SKIN | HTS002 | 1 | -0.000178 | 2.2844 | 0.573641 | 0.566958 | 0.14962 | 0.149597 | valrubicin | DNA inhibitor, topoisomerase inhibitor | TOP2A | oncology | bladder cancer | CCCCC(=O)OCC(=O)[C@@]1(O)C[C@H](O[C@H]2C[C@H](NC(=O)C(F)(F)F)[C@H](O)[C@H](C)O2)c2c(O)c3C(=O)c4c(OC)cccc4C(=O)c3c(O)c2C1 | Launched | true | ACH-001190 |
BRD-K72951360-001-01-4 | ACH-000244 | DKMG_CENTRAL_NERVOUS_SYSTEM | HTS002 | 1 | 0.017272 | 1.05198 | 0.658718 | 0.611354 | 0.218666 | 0.226097 | valrubicin | DNA inhibitor, topoisomerase inhibitor | TOP2A | oncology | bladder cancer | CCCCC(=O)OCC(=O)[C@@]1(O)C[C@H](O[C@H]2C[C@H](NC(=O)C(F)(F)F)[C@H](O)[C@H](C)O2)c2c(O)c3C(=O)c4c(OC)cccc4C(=O)c3c(O)c2C1 | Launched | true | ACH-000244 |
BRD-K72951360-001-01-4 | ACH-000713 | CAOV3_OVARY | HTS002 | 1 | 0.017131 | 2.01534 | 0.696757 | 0.529413 | 0.095981 | 0.097656 | valrubicin | DNA inhibitor, topoisomerase inhibitor | TOP2A | oncology | bladder cancer | CCCCC(=O)OCC(=O)[C@@]1(O)C[C@H](O[C@H]2C[C@H](NC(=O)C(F)(F)F)[C@H](O)[C@H](C)O2)c2c(O)c3C(=O)c4c(OC)cccc4C(=O)c3c(O)c2C1 | Launched | true | ACH-000713 |
BRD-K72951360-001-01-4 | ACH-000672 | IALM_LUNG | HTS002 | 1 | 0.007102 | 1.419754 | 0.27353 | 0.706537 | 0.574931 | 0.580754 | valrubicin | DNA inhibitor, topoisomerase inhibitor | TOP2A | oncology | bladder cancer | CCCCC(=O)OCC(=O)[C@@]1(O)C[C@H](O[C@H]2C[C@H](NC(=O)C(F)(F)F)[C@H](O)[C@H](C)O2)c2c(O)c3C(=O)c4c(OC)cccc4C(=O)c3c(O)c2C1 | Launched | true | ACH-000672 |
BRD-K72951360-001-01-4 | ACH-000875 | NCIH2347_LUNG | HTS002 | 1 | 0.003364 | 2.320311 | 0.606235 | 0.638293 | 0.295475 | 0.296336 | valrubicin | DNA inhibitor, topoisomerase inhibitor | TOP2A | oncology | bladder cancer | CCCCC(=O)OCC(=O)[C@@]1(O)C[C@H](O[C@H]2C[C@H](NC(=O)C(F)(F)F)[C@H](O)[C@H](C)O2)c2c(O)c3C(=O)c4c(OC)cccc4C(=O)c3c(O)c2C1 | Launched | true | ACH-000875 |
BRD-K72951360-001-01-4 | ACH-000423 | SKMEL3_SKIN | HTS002 | 1 | 0.008694 | 1.630648 | 0.644095 | 0.688218 | 0.474602 | 0.479735 | valrubicin | DNA inhibitor, topoisomerase inhibitor | TOP2A | oncology | bladder cancer | CCCCC(=O)OCC(=O)[C@@]1(O)C[C@H](O[C@H]2C[C@H](NC(=O)C(F)(F)F)[C@H](O)[C@H](C)O2)c2c(O)c3C(=O)c4c(OC)cccc4C(=O)c3c(O)c2C1 | Launched | true | ACH-000423 |
BRD-K72951360-001-01-4 | ACH-000553 | SQ1_LUNG | HTS002 | 1 | 0.000225 | 0.9849 | 0.705847 | 0.591108 | 0.192196 | 0.192284 | valrubicin | DNA inhibitor, topoisomerase inhibitor | TOP2A | oncology | bladder cancer | CCCCC(=O)OCC(=O)[C@@]1(O)C[C@H](O[C@H]2C[C@H](NC(=O)C(F)(F)F)[C@H](O)[C@H](C)O2)c2c(O)c3C(=O)c4c(OC)cccc4C(=O)c3c(O)c2C1 | Launched | true | ACH-000553 |
BRD-K72951360-001-01-4 | ACH-000834 | UMUC1_URINARY_TRACT | HTS002 | 1 | 0.007608 | 2.661433 | 0.728885 | 0.574265 | 0.155602 | 0.156501 | valrubicin | DNA inhibitor, topoisomerase inhibitor | TOP2A | oncology | bladder cancer | CCCCC(=O)OCC(=O)[C@@]1(O)C[C@H](O[C@H]2C[C@H](NC(=O)C(F)(F)F)[C@H](O)[C@H](C)O2)c2c(O)c3C(=O)c4c(OC)cccc4C(=O)c3c(O)c2C1 | Launched | true | ACH-000834 |
BRD-K72951360-001-01-4 | ACH-000252 | LS1034_LARGE_INTESTINE | HTS002 | 1 | 1.526605 | -11.82776 | 0.383644 | 1.265758 | 0.081741 | null | valrubicin | DNA inhibitor, topoisomerase inhibitor | TOP2A | oncology | bladder cancer | CCCCC(=O)OCC(=O)[C@@]1(O)C[C@H](O[C@H]2C[C@H](NC(=O)C(F)(F)F)[C@H](O)[C@H](C)O2)c2c(O)c3C(=O)c4c(OC)cccc4C(=O)c3c(O)c2C1 | Launched | true | ACH-000252 |
BRD-K72951360-001-01-4 | ACH-000123 | COV434_OVARY | HTS002 | 1 | -0.004922 | 0.927382 | 0.568327 | 0.550748 | 0.129312 | 0.127954 | valrubicin | DNA inhibitor, topoisomerase inhibitor | TOP2A | oncology | bladder cancer | CCCCC(=O)OCC(=O)[C@@]1(O)C[C@H](O[C@H]2C[C@H](NC(=O)C(F)(F)F)[C@H](O)[C@H](C)O2)c2c(O)c3C(=O)c4c(OC)cccc4C(=O)c3c(O)c2C1 | Launched | true | ACH-000123 |
BRD-K72951360-001-01-4 | ACH-000329 | CCFSTTG1_CENTRAL_NERVOUS_SYSTEM | HTS002 | 1 | 0.00034 | 1.189087 | 0.853967 | 0.643847 | 0.319394 | 0.319577 | valrubicin | DNA inhibitor, topoisomerase inhibitor | TOP2A | oncology | bladder cancer | CCCCC(=O)OCC(=O)[C@@]1(O)C[C@H](O[C@H]2C[C@H](NC(=O)C(F)(F)F)[C@H](O)[C@H](C)O2)c2c(O)c3C(=O)c4c(OC)cccc4C(=O)c3c(O)c2C1 | Launched | true | ACH-000329 |
BRD-K72951360-001-01-4 | ACH-000717 | COLO680N_OESOPHAGUS | HTS002 | 1 | 0.004208 | 1.99485 | 0.835736 | 0.6529 | 0.339819 | 0.341262 | valrubicin | DNA inhibitor, topoisomerase inhibitor | TOP2A | oncology | bladder cancer | CCCCC(=O)OCC(=O)[C@@]1(O)C[C@H](O[C@H]2C[C@H](NC(=O)C(F)(F)F)[C@H](O)[C@H](C)O2)c2c(O)c3C(=O)c4c(OC)cccc4C(=O)c3c(O)c2C1 | Launched | true | ACH-000717 |
BRD-K72951360-001-01-4 | ACH-000669 | SW900_LUNG | HTS002 | 1 | 0.012857 | 0.983017 | 0.562925 | 0.627786 | 0.264251 | 0.271348 | valrubicin | DNA inhibitor, topoisomerase inhibitor | TOP2A | oncology | bladder cancer | CCCCC(=O)OCC(=O)[C@@]1(O)C[C@H](O[C@H]2C[C@H](NC(=O)C(F)(F)F)[C@H](O)[C@H](C)O2)c2c(O)c3C(=O)c4c(OC)cccc4C(=O)c3c(O)c2C1 | Launched | true | ACH-000669 |
BRD-K72951360-001-01-4 | ACH-000764 | SH10TC_STOMACH | HTS002 | 1 | 0.001943 | 2.356529 | 0.812603 | 0.617354 | 0.242246 | 0.242647 | valrubicin | DNA inhibitor, topoisomerase inhibitor | TOP2A | oncology | bladder cancer | CCCCC(=O)OCC(=O)[C@@]1(O)C[C@H](O[C@H]2C[C@H](NC(=O)C(F)(F)F)[C@H](O)[C@H](C)O2)c2c(O)c3C(=O)c4c(OC)cccc4C(=O)c3c(O)c2C1 | Launched | true | ACH-000764 |
BRD-K72951360-001-01-4 | ACH-000288 | BT549_BREAST | HTS002 | 1 | 0.108513 | 3.710038 | 0.650684 | 0.631485 | 0.181084 | 0.193428 | valrubicin | DNA inhibitor, topoisomerase inhibitor | TOP2A | oncology | bladder cancer | CCCCC(=O)OCC(=O)[C@@]1(O)C[C@H](O[C@H]2C[C@H](NC(=O)C(F)(F)F)[C@H](O)[C@H](C)O2)c2c(O)c3C(=O)c4c(OC)cccc4C(=O)c3c(O)c2C1 | Launched | true | ACH-000288 |
BRD-K72951360-001-01-4 | ACH-000415 | BICR6_UPPER_AERODIGESTIVE_TRACT | HTS002 | 1 | 0.004528 | 2.073943 | 0.597898 | 0.663295 | 0.375629 | 0.37728 | valrubicin | DNA inhibitor, topoisomerase inhibitor | TOP2A | oncology | bladder cancer | CCCCC(=O)OCC(=O)[C@@]1(O)C[C@H](O[C@H]2C[C@H](NC(=O)C(F)(F)F)[C@H](O)[C@H](C)O2)c2c(O)c3C(=O)c4c(OC)cccc4C(=O)c3c(O)c2C1 | Launched | true | ACH-000415 |
BRD-K72951360-001-01-4 | ACH-000228 | BICR31_UPPER_AERODIGESTIVE_TRACT | HTS002 | 1 | 0.018961 | 2.158976 | 0.620626 | 0.67782 | 0.4132 | 0.420666 | valrubicin | DNA inhibitor, topoisomerase inhibitor | TOP2A | oncology | bladder cancer | CCCCC(=O)OCC(=O)[C@@]1(O)C[C@H](O[C@H]2C[C@H](NC(=O)C(F)(F)F)[C@H](O)[C@H](C)O2)c2c(O)c3C(=O)c4c(OC)cccc4C(=O)c3c(O)c2C1 | Launched | true | ACH-000228 |
BRD-K72951360-001-01-4 | ACH-000977 | LNCAPCLONEFGC_PROSTATE | HTS002 | 1 | 0.000943 | 0.768614 | 0.904318 | 0.483987 | 0.066041 | 0.066204 | valrubicin | DNA inhibitor, topoisomerase inhibitor | TOP2A | oncology | bladder cancer | CCCCC(=O)OCC(=O)[C@@]1(O)C[C@H](O[C@H]2C[C@H](NC(=O)C(F)(F)F)[C@H](O)[C@H](C)O2)c2c(O)c3C(=O)c4c(OC)cccc4C(=O)c3c(O)c2C1 | Launched | true | ACH-000977 |
BRD-K72951360-001-01-4 | ACH-000397 | TEN_ENDOMETRIUM | HTS002 | 1 | 0.061114 | 4.406642 | 0.357593 | 0.717993 | 0.542176 | 0.558456 | valrubicin | DNA inhibitor, topoisomerase inhibitor | TOP2A | oncology | bladder cancer | CCCCC(=O)OCC(=O)[C@@]1(O)C[C@H](O[C@H]2C[C@H](NC(=O)C(F)(F)F)[C@H](O)[C@H](C)O2)c2c(O)c3C(=O)c4c(OC)cccc4C(=O)c3c(O)c2C1 | Launched | true | ACH-000397 |
BRD-K72951360-001-01-4 | ACH-000565 | RCM1_LARGE_INTESTINE | HTS002 | 1 | 0.023813 | 2.664645 | 0.684641 | 0.616463 | 0.220895 | 0.224978 | valrubicin | DNA inhibitor, topoisomerase inhibitor | TOP2A | oncology | bladder cancer | CCCCC(=O)OCC(=O)[C@@]1(O)C[C@H](O[C@H]2C[C@H](NC(=O)C(F)(F)F)[C@H](O)[C@H](C)O2)c2c(O)c3C(=O)c4c(OC)cccc4C(=O)c3c(O)c2C1 | Launched | true | ACH-000565 |
BRD-K72951360-001-01-4 | ACH-000209 | SNU1079_BILIARY_TRACT | HTS002 | 1 | 0.027572 | 1.355715 | 0.584836 | 0.612576 | 0.210144 | 0.219123 | valrubicin | DNA inhibitor, topoisomerase inhibitor | TOP2A | oncology | bladder cancer | CCCCC(=O)OCC(=O)[C@@]1(O)C[C@H](O[C@H]2C[C@H](NC(=O)C(F)(F)F)[C@H](O)[C@H](C)O2)c2c(O)c3C(=O)c4c(OC)cccc4C(=O)c3c(O)c2C1 | Launched | true | ACH-000209 |
BRD-K72951360-001-01-4 | ACH-000927 | BT474_BREAST | HTS002 | 1 | 0.014355 | 1.996327 | 0.484027 | 0.790191 | 1.277749 | 1.29653 | valrubicin | DNA inhibitor, topoisomerase inhibitor | TOP2A | oncology | bladder cancer | CCCCC(=O)OCC(=O)[C@@]1(O)C[C@H](O[C@H]2C[C@H](NC(=O)C(F)(F)F)[C@H](O)[C@H](C)O2)c2c(O)c3C(=O)c4c(OC)cccc4C(=O)c3c(O)c2C1 | Launched | true | ACH-000927 |
BRD-K33127281-001-05-6 | ACH-000879 | MFE296_ENDOMETRIUM | HTS002 | 1 | 0.849044 | 3.954647 | -0.202302 | 0.929897 | 0.11037 | null | adapalene | retinoid receptor agonist | RARA, RARB, RARG, RXRA, RXRB, RXRG | dermatology | acne vulgaris (AV) | COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O | Launched | true | ACH-000879 |
BRD-K33127281-001-05-6 | ACH-000320 | PSN1_PANCREAS | HTS002 | 1 | 1.737547 | -1.382851 | 0.500866 | 1.402403 | 0.121745 | null | adapalene | retinoid receptor agonist | RARA, RARB, RARG, RXRA, RXRB, RXRG | dermatology | acne vulgaris (AV) | COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O | Launched | true | ACH-000320 |
BRD-K33127281-001-05-6 | ACH-001145 | OC316_OVARY | HTS002 | 1 | 0.487786 | 13.984601 | 0.169551 | 0.882032 | 1.069981 | 1.395257 | adapalene | retinoid receptor agonist | RARA, RARB, RARG, RXRA, RXRB, RXRG | dermatology | acne vulgaris (AV) | COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O | Launched | true | ACH-001145 |
BRD-K33127281-001-05-6 | ACH-000873 | KYSE270_OESOPHAGUS | HTS002 | 1 | 0.050735 | 3.482917 | 0.406842 | 0.935022 | 5.302784 | 5.468214 | adapalene | retinoid receptor agonist | RARA, RARB, RARG, RXRA, RXRB, RXRG | dermatology | acne vulgaris (AV) | COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O | Launched | true | ACH-000873 |
BRD-K33127281-001-05-6 | ACH-000855 | KYSE150_OESOPHAGUS | HTS002 | 1 | 0.434114 | 6.404074 | 0.071247 | 0.958265 | 4.896345 | 6.719124 | adapalene | retinoid receptor agonist | RARA, RARB, RARG, RXRA, RXRB, RXRG | dermatology | acne vulgaris (AV) | COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O | Launched | true | ACH-000855 |
BRD-K33127281-001-05-6 | ACH-000913 | ESS1_ENDOMETRIUM | HTS002 | 1 | 1.865222 | -0.546365 | 0.1651 | 1.36739 | 0.033514 | null | adapalene | retinoid receptor agonist | RARA, RARB, RARG, RXRA, RXRB, RXRG | dermatology | acne vulgaris (AV) | COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O | Launched | true | ACH-000913 |
BRD-K33127281-001-05-6 | ACH-000558 | A172_CENTRAL_NERVOUS_SYSTEM | HTS002 | 1 | 2.327762 | -0.160136 | 0.069159 | 1.435317 | 0.000713 | null | adapalene | retinoid receptor agonist | RARA, RARB, RARG, RXRA, RXRB, RXRG | dermatology | acne vulgaris (AV) | COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O | Launched | true | ACH-000558 |
BRD-K33127281-001-05-6 | ACH-000593 | BC3C_URINARY_TRACT | HTS002 | 1 | 1.608741 | -0.739131 | 0.162436 | 1.245092 | 0.028633 | null | adapalene | retinoid receptor agonist | RARA, RARB, RARG, RXRA, RXRB, RXRG | dermatology | acne vulgaris (AV) | COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O | Launched | true | ACH-000593 |
BRD-K33127281-001-05-6 | ACH-000488 | TE11_OESOPHAGUS | HTS002 | 1 | 1.340848 | -6.182332 | 0.271935 | 1.097271 | 0.009734 | null | adapalene | retinoid receptor agonist | RARA, RARB, RARG, RXRA, RXRB, RXRG | dermatology | acne vulgaris (AV) | COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O | Launched | true | ACH-000488 |
BRD-K33127281-001-05-6 | ACH-000832 | CAL27_UPPER_AERODIGESTIVE_TRACT | HTS002 | 1 | 1.381381 | -8.743307 | 0.28694 | 1.246475 | 0.323023 | null | adapalene | retinoid receptor agonist | RARA, RARB, RARG, RXRA, RXRB, RXRG | dermatology | acne vulgaris (AV) | COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O | Launched | true | ACH-000832 |
BRD-K33127281-001-05-6 | ACH-000781 | NCIH2023_LUNG | HTS002 | 1 | 0.539246 | 1.337504 | -0.025868 | 0.878805 | 0.798529 | null | adapalene | retinoid receptor agonist | RARA, RARB, RARG, RXRA, RXRB, RXRG | dermatology | acne vulgaris (AV) | COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O | Launched | true | ACH-000781 |
BRD-K33127281-001-05-6 | ACH-000833 | RH30_SOFT_TISSUE | HTS002 | 1 | 0.99723 | 0.502818 | -0.185026 | 0.998381 | 0.029232 | null | adapalene | retinoid receptor agonist | RARA, RARB, RARG, RXRA, RXRB, RXRG | dermatology | acne vulgaris (AV) | COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O | Launched | true | ACH-000833 |
BRD-K33127281-001-05-6 | ACH-000137 | 8MGBA_CENTRAL_NERVOUS_SYSTEM | HTS002 | 1 | 1.402124 | -1.015582 | 0.296663 | 1.194493 | 0.066518 | null | adapalene | retinoid receptor agonist | RARA, RARB, RARG, RXRA, RXRB, RXRG | dermatology | acne vulgaris (AV) | COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O | Launched | true | ACH-000137 |
BRD-K33127281-001-05-6 | ACH-000632 | HS944T_SKIN | HTS002 | 1 | 1.922885 | -0.747982 | 0.327315 | 1.417865 | 0.048162 | null | adapalene | retinoid receptor agonist | RARA, RARB, RARG, RXRA, RXRB, RXRG | dermatology | acne vulgaris (AV) | COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O | Launched | true | ACH-000632 |
BRD-K33127281-001-05-6 | ACH-000319 | MPP89_PLEURA | HTS002 | 1 | 2.462564 | 0.017592 | -0.010068 | 1.716165 | 0.820747 | null | adapalene | retinoid receptor agonist | RARA, RARB, RARG, RXRA, RXRB, RXRG | dermatology | acne vulgaris (AV) | COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O | Launched | true | ACH-000319 |
BRD-K33127281-001-05-6 | ACH-000630 | YD8_UPPER_AERODIGESTIVE_TRACT | HTS002 | 1 | 2.214256 | -0.566315 | 0.011853 | 1.322037 | 0.005172 | null | adapalene | retinoid receptor agonist | RARA, RARB, RARG, RXRA, RXRB, RXRG | dermatology | acne vulgaris (AV) | COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O | Launched | true | ACH-000630 |
BRD-K33127281-001-05-6 | ACH-000266 | SNU213_PANCREAS | HTS002 | 1 | 2.159894 | -1.288617 | 0.27069 | 1.348307 | 0.011046 | null | adapalene | retinoid receptor agonist | RARA, RARB, RARG, RXRA, RXRB, RXRG | dermatology | acne vulgaris (AV) | COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O | Launched | true | ACH-000266 |
BRD-K33127281-001-05-6 | ACH-000047 | GCIY_STOMACH | HTS002 | 1 | 0.910948 | 1.061227 | 0.031364 | 0.961703 | 0.155347 | null | adapalene | retinoid receptor agonist | RARA, RARB, RARG, RXRA, RXRB, RXRG | dermatology | acne vulgaris (AV) | COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O | Launched | true | ACH-000047 |
BRD-K33127281-001-05-6 | ACH-000273 | SF539_CENTRAL_NERVOUS_SYSTEM | HTS002 | 1 | 0.276477 | 4.331261 | 0.065141 | 0.934789 | 4.192298 | 5.048692 | adapalene | retinoid receptor agonist | RARA, RARB, RARG, RXRA, RXRB, RXRG | dermatology | acne vulgaris (AV) | COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O | Launched | true | ACH-000273 |
BRD-K33127281-001-05-6 | ACH-000682 | SNU1066_UPPER_AERODIGESTIVE_TRACT | HTS002 | 1 | 37.682801 | 0.396817 | -0.007881 | 1 | 6,866,549,762,904,510,000,000,000,000 | null | adapalene | retinoid receptor agonist | RARA, RARB, RARG, RXRA, RXRB, RXRG | dermatology | acne vulgaris (AV) | COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O | Launched | true | ACH-000682 |
BRD-K33127281-001-05-6 | ACH-000804 | NB1_AUTONOMIC_GANGLIA | HTS002 | 1 | 0.918148 | 0.476165 | 0.00821 | 0.937027 | 0.002505 | null | adapalene | retinoid receptor agonist | RARA, RARB, RARG, RXRA, RXRB, RXRG | dermatology | acne vulgaris (AV) | COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O | Launched | true | ACH-000804 |
BRD-K33127281-001-05-6 | ACH-000609 | SF126_CENTRAL_NERVOUS_SYSTEM | HTS002 | 1 | 0.816035 | -0.070718 | -0.135369 | 0.911807 | 0.024075 | null | adapalene | retinoid receptor agonist | RARA, RARB, RARG, RXRA, RXRB, RXRG | dermatology | acne vulgaris (AV) | COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O | Launched | true | ACH-000609 |
BRD-K33127281-001-05-6 | ACH-000974 | SNGM_ENDOMETRIUM | HTS002 | 1 | 2.474709 | 0.198921 | 0.115868 | 1.431162 | 9.137359 | null | adapalene | retinoid receptor agonist | RARA, RARB, RARG, RXRA, RXRB, RXRG | dermatology | acne vulgaris (AV) | COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O | Launched | true | ACH-000974 |
BRD-K33127281-001-05-6 | ACH-000987 | MEWO_SKIN | HTS002 | 1 | 1.431734 | -1.090366 | 0.269235 | 1.23005 | 0.107811 | null | adapalene | retinoid receptor agonist | RARA, RARB, RARG, RXRA, RXRB, RXRG | dermatology | acne vulgaris (AV) | COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O | Launched | true | ACH-000987 |
BRD-K33127281-001-05-6 | ACH-000787 | LXF289_LUNG | HTS002 | 1 | 0.438543 | 3.703128 | 0.520743 | 0.811488 | 0.384575 | 0.677372 | adapalene | retinoid receptor agonist | RARA, RARB, RARG, RXRA, RXRB, RXRG | dermatology | acne vulgaris (AV) | COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O | Launched | true | ACH-000787 |
BRD-K33127281-001-05-6 | ACH-000561 | TT_OESOPHAGUS | HTS002 | 1 | 0.492826 | 0.901488 | 0.288068 | 0.842049 | 0.523595 | 58.022526 | adapalene | retinoid receptor agonist | RARA, RARB, RARG, RXRA, RXRB, RXRG | dermatology | acne vulgaris (AV) | COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O | Launched | true | ACH-000561 |
BRD-K33127281-001-05-6 | ACH-000212 | CAL120_BREAST | HTS002 | 1 | 0.544539 | 3.163986 | 0.04655 | 0.954074 | 3.814143 | null | adapalene | retinoid receptor agonist | RARA, RARB, RARG, RXRA, RXRB, RXRG | dermatology | acne vulgaris (AV) | COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O | Launched | true | ACH-000212 |
BRD-K33127281-001-05-6 | ACH-000753 | JMSU1_URINARY_TRACT | HTS002 | 1 | 1.031713 | 0.177749 | -0.060645 | 1.020821 | 0.001644 | null | adapalene | retinoid receptor agonist | RARA, RARB, RARG, RXRA, RXRB, RXRG | dermatology | acne vulgaris (AV) | COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O | Launched | true | ACH-000753 |
BRD-K33127281-001-05-6 | ACH-000305 | ECGI10_OESOPHAGUS | HTS002 | 1 | 1.258745 | -1.510292 | 0.172618 | 1.135063 | 0.096738 | null | adapalene | retinoid receptor agonist | RARA, RARB, RARG, RXRA, RXRB, RXRG | dermatology | acne vulgaris (AV) | COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O | Launched | true | ACH-000305 |
BRD-K33127281-001-05-6 | ACH-000138 | CFPAC1_PANCREAS | HTS002 | 1 | 1.326665 | -0.254608 | 0.022918 | 1.133191 | 0.015063 | null | adapalene | retinoid receptor agonist | RARA, RARB, RARG, RXRA, RXRB, RXRG | dermatology | acne vulgaris (AV) | COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O | Launched | true | ACH-000138 |
BRD-K33127281-001-05-6 | ACH-000250 | KMRC20_KIDNEY | HTS002 | 1 | 0.82284 | 1.251709 | -0.022302 | 0.938742 | 0.353066 | null | adapalene | retinoid receptor agonist | RARA, RARB, RARG, RXRA, RXRB, RXRG | dermatology | acne vulgaris (AV) | COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O | Launched | true | ACH-000250 |
BRD-K33127281-001-05-6 | ACH-000856 | CAL51_BREAST | HTS002 | 1 | 1.987454 | -0.650067 | 0.61846 | 1.311349 | 0.010594 | null | adapalene | retinoid receptor agonist | RARA, RARB, RARG, RXRA, RXRB, RXRG | dermatology | acne vulgaris (AV) | COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O | Launched | true | ACH-000856 |
BRD-K33127281-001-05-6 | ACH-000046 | ACHN_KIDNEY | HTS002 | 1 | 0.146158 | 2.005872 | 0.381754 | 0.802156 | 1.061372 | 1.261037 | adapalene | retinoid receptor agonist | RARA, RARB, RARG, RXRA, RXRB, RXRG | dermatology | acne vulgaris (AV) | COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O | Launched | true | ACH-000046 |
BRD-K33127281-001-05-6 | ACH-000878 | HCC15_LUNG | HTS002 | 1 | 0.420434 | 4.39212 | 0.372982 | 0.932905 | 3.257005 | 4.94952 | adapalene | retinoid receptor agonist | RARA, RARB, RARG, RXRA, RXRB, RXRG | dermatology | acne vulgaris (AV) | COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O | Launched | true | ACH-000878 |
BRD-K33127281-001-05-6 | ACH-000766 | NCIH1648_LUNG | HTS002 | 1 | 0.878071 | 3.722253 | -0.034243 | 0.960913 | 0.445638 | null | adapalene | retinoid receptor agonist | RARA, RARB, RARG, RXRA, RXRB, RXRG | dermatology | acne vulgaris (AV) | COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O | Launched | true | ACH-000766 |
BRD-K33127281-001-05-6 | ACH-000014 | HS294T_SKIN | HTS002 | 1 | 2.396746 | -0.611737 | 0.273842 | 1.326384 | 0.003749 | null | adapalene | retinoid receptor agonist | RARA, RARB, RARG, RXRA, RXRB, RXRG | dermatology | acne vulgaris (AV) | COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O | Launched | true | ACH-000014 |
BRD-K33127281-001-05-6 | ACH-000884 | MDAMB435S_SKIN | HTS002 | 1 | 0.827756 | 2.821718 | 0.079311 | 0.923606 | 0.135145 | null | adapalene | retinoid receptor agonist | RARA, RARB, RARG, RXRA, RXRB, RXRG | dermatology | acne vulgaris (AV) | COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O | Launched | true | ACH-000884 |
BRD-K33127281-001-05-6 | ACH-000504 | SNB75_CENTRAL_NERVOUS_SYSTEM | HTS002 | 1 | 0.704818 | 0.588312 | -0.188464 | 0.877953 | 0.201495 | null | adapalene | retinoid receptor agonist | RARA, RARB, RARG, RXRA, RXRB, RXRG | dermatology | acne vulgaris (AV) | COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O | Launched | true | ACH-000504 |
BRD-K33127281-001-05-6 | ACH-000502 | TCCPAN2_PANCREAS | HTS002 | 1 | 2.041524 | -7.752992 | 0.318321 | 1.556531 | 0.109024 | null | adapalene | retinoid receptor agonist | RARA, RARB, RARG, RXRA, RXRB, RXRG | dermatology | acne vulgaris (AV) | COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O | Launched | true | ACH-000502 |
BRD-K33127281-001-05-6 | ACH-000886 | NCIH2009_LUNG | HTS002 | 1 | 1.484839 | -0.399245 | 0.087434 | 1.221558 | 0.044662 | null | adapalene | retinoid receptor agonist | RARA, RARB, RARG, RXRA, RXRB, RXRG | dermatology | acne vulgaris (AV) | COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O | Launched | true | ACH-000886 |
BRD-K33127281-001-05-6 | ACH-000035 | NCIH1650_LUNG | HTS002 | 1 | 1.433031 | 0.120566 | -0.052945 | 1.223839 | 0.043865 | null | adapalene | retinoid receptor agonist | RARA, RARB, RARG, RXRA, RXRB, RXRG | dermatology | acne vulgaris (AV) | COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O | Launched | true | ACH-000035 |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.