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Context: Oil Rush is a tower defense real-time strategy game developed by Unigine Corp using their Unigine engine technology.
Question: Who is originally behind the development of Oil Rush? | [
"unigine corp"
] | task469-3d91acef70344082bc060bdac47507f8 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: SEA0400 is a selective inhibitor of the Na(+)/Ca(2+) exchanger having equal potencies to suppress both the forward and reverse mode operation of the Na(+)/Ca(2+) exchanger. Present experiments were designed to study the effect of partial blockade of Na(+)/Ca(2+) exchanger on Ca(2+) handling in isolated rat ventricular myocytes. Intracellular Ca(2+) transient and cell shortening were measured in ventricular myocytes loaded with Fura-2-AM fluorescent dye. Partial blockade of Na(+)/Ca(2+) exchanger was induced by superfusion of the cells with SEA0400 at a concentration of 0.3 microM. Amplitude of the intracellular Ca(2+) transient and cell shortening was significantly increased by SEA0400 in both field stimulated and voltage clamped myocytes, without significant elevation of diastolic Ca(2+) level and the decay time constant of the Ca(2+) transient. In patch clamped myocytes the SEA0400 induced increase in the Ca(2+) transient and cell shortening was accompanied by significant reduction of peak L-type Ca(2+) current. These effects can be explained by the autoregulative nature of cardiac Ca(2+) handling, as the reduced Ca(2+) efflux from the cell results in an increased Ca(2+) load to the sarcoplasmic reticulum leading to increased Ca(2+) release, which in turn may decrease the L-type Ca(2+) current by accelaration of Ca(2+) dependent inactivation of L-type Ca(2+) current. Our results suggest that complex changes in the Ca(2+) cycling can occur after selective pharmacological inhibition of the Na(+)/Ca(2+) exchanger.
Question: The small molecule SEA0400 is an inhibitor of which ion antiporter/exchanger? | [
"na(+)/ca(2+) exchanger",
"ncx"
] | task469-65cdb0240df342a1b3722bef637d5ddb | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: In the 1950s, a family that owned a farm near Beulah, Michigan kept a bull chained to an elm . The bull paced around the tree, dragging the heavy iron chain, which led to a groove in the bark . The groove deepened over the years. Though for whatever reason, it did not kill the tree. After some years, the family took their bull away. They cut the chain, leaving the loop around the tree and one link hanging down. Then one year, agricultural disaster struck Michigan in the form of Dutch Elm Disease. All of the elms lining the road leading to the farm became infected and died. Everyone thought that the old elm would be the next. The farm owners considered doing the safe thing: pulling it out and cutting it up into firewood before it died. But they simply could not bring themselves to do it. It was as if the old tree had become a family friend. So they decided to let nature take its course. Amazingly, the tree did not die. Nobody could understand why it was the only elm still standing in the county! Plant experts from Michigan State University came out to observe the tree. They observed the scar left by the iron chain, now almost completely covered by bark. The experts decided that it was the chain that saved the elm's life. They reasoned that the tree must have absorbed so much iron from the chain that it became immune to the virus. It's said that what doesn't kill you will make you stronger. Or, as Earnest Hemingway put it, "Life breaks us all, but afterwards, many of us are strongest at the broken places."
Question: What actually saved the elm? | [
"the iron chain."
] | task469-0ea20d5b4e4b409fa0f1250a7376f610 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: Einar Billing born 6 October 1871 in Lund, died 17 December 1939 in Vasteras, was a Swedish hymnwriter and theologian.
Question: What city did Einar Billing live when he died? | [
"västerås"
] | task469-6109c7cc222c4d60bca7e713139786ac | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: The Angels first take note of "Poet" (Jack Nicholson) after one of them inadvertently damages his motorcycle and breaks its headlight. Poet, with far more guts than brains, challenges the Angel that hit his motorcycle. This is an act that would traditionally result in every Angel present participating in a group beating of the attacker. "When a non-Angel hits an Angel, all Angels retaliate." But the leader of the Angels, Buddy (Adam Roarke), intervenes and tells Poet that the Angels will replace the headlight. In the meantime, he's welcome to ride with them while they take care of businesswhich turns out to be going to a bar and beating up the members of another club who previously beat an Angel. Poet is told to wait outside, but ends up helping the Angels. Later that night, the Angels return the favor by hunting down and beating four sailors who beat Poet four-against-one after he parted company with the group. Poet accidentally bumps into one of the sailors and speaks rudely to him before he realizes that the sailor has three other sailors with him. The four sailors then refuse to accept his apologybut the Angels only know that four sailors beat up Poet, and he doesn't tell them how the earlier fight started. One of the sailors pulls a knife on the Angels and is then killed accidentally in the fight that follows. Poet is allowed to ride with the Angels and is eventually elevated to "prospect" status. He is attracted to Buddy's some-time girlfriend (Sabrina Scharf) who toys with him while remaining hopelessly committed to Buddy. Much of the story that follows consists of scenes of the Angels partying or being provoked to violence by "squares." Although the Angels are shown as being loud and generally irreverent, they are never shown starting trouble except when taking revenge on members of other motorcycle clubs. Eventually, Buddy's girlfriend succeeds in provoking a confrontation between Buddy and Poet with only one surviving.
Question: Who loves the same woman as Poet? | [
"buddy"
] | task469-8269fb5300e84e69866b81a7ee0ff423 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: Our surroundings are being polluted faster than nature and man's present efforts cannot prevent it. Time is bringing us more people, and more people will bring us more industry, more cars, larger cities, and the growing use of man-made materials. What can explain and solve this problem? The fact is that pollution is caused by man--by his desire for a modern way of life. We make "increasing industrialization" our chief aim. So we are often ready to offer everything: clean air, pure water, good food, our health and the future of our children. There is a constant flow of people from the countryside into the cities, eager for the benefits of our modern society. But as our technological achievements have grown in the last twenty years, pollution has become a serious problem. Isn't it time we stopped to ask ourselves where we are going--and why? It makes one think of the story about the airline pilot who told his passengers over the loudspeaker, "I've some good news and some bad news. The good news is that we're making rapid progress at 530 miles per hour. The bad news is that we're lost and don't know where we're going." The sad fact is that this becomes a true story when spoken of our modern society.
Question: According to the passage, what does man value most? | [
"industry."
] | task469-4270b0c55b3948088082de7c61dac50c | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: When a new moon passes directly between the Earth and the Sun, it causes a solar eclipse (Figure 24.20). The Moon casts a shadow on the Earth and blocks our view of the Sun. This happens only all three are lined up and in the same plane. This plane is called the ecliptic. The ecliptic is the plane of Earths orbit around the Sun. The Moons shadow has two distinct parts. The umbra is the inner, cone-shaped part of the shadow. It is the part in which all of the light has been blocked. The penumbra is the outer part of Moons shadow. It is where the light is only partially blocked. When the Moons shadow completely blocks the Sun, it is a total solar eclipse (Figure 24.21). If only part of the Sun is out of view, it is a partial solar eclipse. Solar eclipses are rare events. They usually only last a few minutes. That is because the Moons shadow only covers a very small area on Earth and Earth is turning very rapidly. Solar eclipses are amazing to experience. It appears like night only strange. Birds may sing as they do at dusk. Stars become visible in the sky and it gets colder outside. Unlike at night, the Sun is out. So during a solar eclipse, its easy to see the Suns corona and solar prominences. This NASA page will inform you on when solar eclipses are expected: [Link] Sometimes a full moon moves through Earths shadow. This is a lunar eclipse (Figure 24.22). During a total lunar eclipse, the Moon travels completely in Earths umbra. During a partial lunar eclipse, only a portion of the Moon enters Earths umbra. When the Moon passes through Earths penumbra, it is a penumbral eclipse. Since Earths shadow is large, a lunar eclipse lasts for hours. Anyone with a view of the Moon can see a lunar eclipse. Partial lunar eclipses occur at least twice a year, but total lunar eclipses are less common. The Moon glows with a dull red coloring during a total lunar eclipse. The Moon does not produce any light of its own. It only reflects light from the Sun. As the Moon moves around the Earth, we see different parts of the Moon lit up by the Sun. This causes the phases of the Moon. As the Moon revolves around Earth, it changes from fully lit to completely dark and back again. A full moon occurs when the whole side facing Earth is lit. This happens when Earth is between the Moon and the Sun. About one week later, the Moon enters the quarter-moon phase. Only half of the Moons lit surface is visible from Earth, so it appears as a half circle. When the Moon moves between Earth and the Sun, the side facing Earth is completely dark. This is called the new moon phase. Sometimes you can just barely make out the outline of the new moon in the sky. This is because some sunlight reflects off the Earth and hits the Moon. Before and after the quarter-moon phases are the gibbous and crescent phases. During the crescent moon phase, the Moon is less than half lit. It is seen as only a sliver or crescent shape. During the gibbous moon phase, the Moon is more than half lit. It is not full. The Moon undergoes a complete cycle of phases about every 29.5 days.
Question: A total solar eclipse occurs when | [
"the moons shadow completely blocks the sun."
] | task469-fa41614f48ed410f9a1807fa9979c472 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: Filmed on location in the Los Angeles area and at the Universal Studios during March and April 1969, Change of Habit was released in the United States on November 10, 1969.
Question: What studio realeased the movie Change of Habit? | [
"universal studios"
] | task469-322a3386ca714ce9aec32ca3fa12caa9 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: In August 1962, Eva Hesse and Tom Doyle participated in an Allan Kaprow Happening at the Art Students League of New York in Woodstock, New York.
Question: What is the name of university that educated Eva Hesse? | [
"art students league of new york"
] | task469-632e1f719e1a4ca9b6ececfccf0d7e37 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: In 1749, Britain and France agreed to keep the island neutral, but Britain took control after 1763, prompting France to capture the island in 1781, then Britain to recapture the island in 1793. The population in 1771 was 5,084, of which only 243 were white and 4,716 were slaves. In 1791 the population was 15,020, of which 541 were white and 14,170 were slaves. There were then 37 sugar factories, 99 cotton factories, and 4 coffee factories. After nutmeg was discovered in 1768, 40 nutmeg plantations were started. The island became a British acquisition for good in 1802, with a ratified treaty in 1814.
Question: Which group was bigger, white or slaves? | [
"slaves"
] | task469-cdf0435166b64203a995cb2c17bb99e3 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: While the United States continued missions to the Moon in the early 1970s, the Soviets worked to build a space station. A space station is a large spacecraft. People can live on this craft for a long period of time. Between 1971 and 1982, the Soviets put a total of seven Salyut space stations into orbit. Figure 23.22 shows the last of these, Salyut 7. These were all temporary stations. They were launched and later inhabited by a human crew. Three of the Salyut stations were used for secret military purposes. The others were used to study the problems of living in space. Cosmonauts aboard the stations performed a variety of experiments in astronomy, biology, and Earth science. Salyut 6 and Salyut 7 each had two docking ports. One crew could dock a spacecraft to one end. A replacement crew could dock to the other end. The U.S. only launched one space station during this time. It was called Skylab. Skylab was launched in May 1973. Three crews visited Skylab, all within its first year in orbit. Skylab was used to study the effects of staying in space for long period. Devices on board were and for studying the Sun. Skylab reentered Earths atmosphere in 1979, sooner than expected. The first space station designed for long-term use was the Mir space station (Figure 23.23). Mir was launched in several separate pieces. These pieces were put together in space. Mir holds the current record for the longest continued presence in space. There were people living on Mir continuously for almost 10 years! Mir was the first major space project in which the United States and Russia worked together. American space shuttles transported supplies and people to and from Mir. American astronauts lived on Mir for many months. This cooperation allowed the two nations to learn from each other. The U.S. learned about Russias experiences with long-duration space flights. Mir was taken out of orbit in 2001. It fell into the Pacific Ocean. The International Space Station, shown in Figure 23.24 is a joint project between the space agencies of many nations These include the United States (NASA), Russia (RKA), Japan (JAXA), Canada (CSA), several European countries (ESA) and the Brazilian Space Agency. The International Space Station is a very large station. It has many different sections and is still being assembled. The station has had people on board since 2000. American space shuttles deliver most of the supplies and equipment to the station. Russian Soyuz spacecraft carry people. The primary purpose of the station is scientific research. This is important because the station has a microgravity environment. Experiments are done in the fields of biology, chemistry, physics, physiology and medicine. NASA wanted a new kind of space vehicle. This vehicle had to be reusable. It had to able to carry large pieces of equipment, such as satellites, space telescopes, or sections of a space station. The new vehicle was called a space shuttle, shown in Figure 23.25. There have been five space shuttles: Columbia, Challenger, Discovery, Atlantis, and Endeavor. A space shuttle has three main parts. You are probably most familiar with the orbiter. This part has wings like At the end of the mission, the orbiter re-enters Earths atmosphere. The outside heats up as it descends. Pilots have to steer the shuttle to the runway very precisely. Space shuttles usually land at Kennedy Space Center or at Edwards Air Force Base in California. The orbiter is later hauled back to Florida on the back of a jet airplane. The space shuttle program has been very successful. Over 100 mission have been flown. Space shuttle missions have made many scientific discoveries. Crews have launched many satellites. There have been other great achievements in space. However, the program has also had two tragic disasters. The first came just 73 seconds after launch, on January 28, 1986. The space shuttle Challenger disintegrated in mid-air, as shown in Figure 23.27. On board were seven crew members. All of them died. One of them was Christa McAuliffe, who was to be the first teacher in space.
Question: reusable space vehicle for carrying equipment and people to and from space | [
"space shuttle"
] | task469-06cc3cc44e4e47528b097e8e4d68acfe | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: The Paraul Malurilor is a tributary of the Dragan River in Romania.
Question: Which country is Paraul Malurilor in? | [
"romania"
] | task469-76b382842ce249b5bd7baa8350b4185a | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: In 1953, 10-year-old Larry Flynt is selling moonshine in Kentucky. Twenty years later, Flynt (Woody Harrelson) and his younger brother, Jimmy (Brett Harrelson) run the Hustler Go-Go club in Cincinnati. With profits down, Flynt decides to publish a newsletter for the club, the first Hustler magazine, with nude pictures of women working at the club. The newsletter soon becomes a full-fledged magazine, but sales are weak. In 1975, after Hustler publishes nude pictures of former first lady Jackie Kennedy Onassis, sales take off.Flynt becomes smitten with Althea Leasure (Courtney Love), a stripper who works at one of his clubs. With Althea and Jimmy's help, Flynt makes a fortune from sales of Hustler. With his success comes enemies - as he finds himself a hated figure of anti-pornography activists. He argues with the activists, saying that "murder is illegal, but if you take a picture of it you may get your name in a magazine or maybe win a Pulitzer Prize". "However", he continues, "sex is legal, but if you take a picture of that act, you can go to jail". He becomes involved in several prominent court cases, and befriends a young lawyer, Alan Isaacman (Edward Norton). In 1975, Flynt loses a smut-peddling court decision in Cincinnati but is released from jail soon afterwards on a technicality. Ruth Carter Stapleton (Hanover), a Christian activist and sister of President Jimmy Carter, seeks out Flynt and urges him to give his life to Jesus. Flynt seems moved and starts letting his newfound religion influence everything in his life, including Hustler content.In 1978, during another trial in Georgia, Flynt and Isaacman are both shot by a man with a rifle while they walk outside a courthouse. Isaacman recovers, but Flynt is paralyzed from the waist down and uses a wheelchair for the rest of his life. Wishing he was dead, Flynt renounces God. Because of the emotional and physical pain, he moves to Beverly Hills, California and spirals down into depression and drug use. During this time, Althea also becomes addicted to painkillers and morphine.In 1983, Flynt undergoes back surgery to deaden several nerves, and as a result, feels rejuvenated. He returns to an active role with the publication, which, in his absence, had been run by Althea and Jimmy. That same year, Flynt is soon in court again for leaking videos relating to the John DeLorean entrapment case, and during his courtroom antics, he fires Isaacman, then throws an orange at the judge. He later wears an American flag as an adult diaper along with an army helmet, and wears T-shirts with provocative messages such as "I Wish I Was Black" and "Fuck This Court." After spitting water at the judge Flynt is sent to a psychiatric ward, where he sinks into depression again. He is diagnosed with having bipolar disorder and forced to take treatment.During this time, Flynt publishes a satirical parody ad in which Christian fundamentalist preacher Jerry Falwell tells of a sexual encounter with his mother. Falwell sues for libel and emotional distress. Flynt countersues for copyright infringement, because Falwell copied his ad. The case goes to trial in December 1984, but the decision is mixed, as Flynt is found guilty of inflicting emotional distress but not libel.By that time, Althea has contracted HIV, which proceeds to AIDS. Some time later in 1987, Flynt finds her dead in the bathtub, having drowned. Flynt presses Isaacman to appeal the Falwell decision to the Supreme Court of the United States. Isaacman refuses, saying Flynt's courtroom antics humiliated him. Flynt pleads with him, saying that he "wants to be remembered for something meaningful". Isaacman agrees and argues the "emotional distress" decision in front of the Supreme Court, in the case Hustler Magazine v. Falwell in 1988. With Flynt in the courtroom, the court overturns the original verdict in a unanimous decision. After the trial, Flynt is alone in his bedroom watching old videotapes of a healthy Althea.
Question: What decision does Isaacman argue in front of the Supreme Court? | [
"emotional distress"
] | task469-5cde8dfb5249489e8d6668e6a0e19e2d | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: Viroids are small, circular, single-stranded RNA molecules that cause several infectious plant diseases. Viroids do not encode any pathogen-specific peptides but nonetheless, the subviral pathogens replicate autonomously and spread in the plant by recruiting host proteins via functional motifs encoded in their RNA genome. During the past couple of years, considerable progress has been made towards comprehending how viroids interact with their hosts. Here, we summarize recent findings on the structure-function relationships of viroids, their strategies and mechanisms of replication and trafficking, and the identification and characterization of interacting host proteins. We also describe the impact of the RNA silencing machinery of plants on viroid RNAs and how this has started to influence our models of viroid replication and pathogenicity.
Question: Which are the smallest known subviral pathogens of plants? | [
"viroids"
] | task469-3d72fd58929240a5965f4f70b580ee5d | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: Gravity has traditionally been defined as a force of attraction between two masses. According to this conception of gravity, anything that has mass, no matter how small, exerts gravity on other matter. The effect of gravity is that objects exert a pull on other objects. Unlike friction, which acts only between objects that are touching, gravity also acts between objects that are not touching. In fact, gravity can act over very long distances. You are already very familiar with Earths gravity. It constantly pulls you toward the center of the planet. It prevents you and everything else on Earth from being flung out into space as the planet spins on its axis. It also pulls objects above the surface, from meteors to skydivers, down to the ground. Gravity between Earth and the moon and between Earth and artificial satellites keeps all these objects circling around Earth. Gravity also keeps Earth moving around the sun. Weight measures the force of gravity pulling on an object. Because weight measures force, the SI unit for weight is the newton (N). On Earth, a mass of 1 kilogram has a weight of about 10 newtons because of the pull of Earths gravity On the moon, which has less gravity, the same mass would weigh less. Weight is measured with a scale, like the spring scale in Figure 13.16. The scale measures the force with which gravity pulls an object downward. People have known about gravity for thousands of years. After all, they constantly experienced gravity in their daily lives. They knew that things always fall toward the ground. However, it wasnt until Sir Isaac Newton developed his law of gravity in the late 1600s that people really began to understand gravity. Newton is pictured in Figure 13.17. Newton was the first one to suggest that gravity is universal and affects all objects in the universe. Thats why his law of gravity is called the law of universal gravitation. Universal gravitation means that the force that causes an apple to fall from a tree to the ground is the same force that causes the moon to keep moving around Earth. Universal gravitation also means that while Earth exerts a pull on you, you exert a pull on Earth. In fact, there is gravity between you and every mass around you your desk, your book, your pen. Even tiny molecules of gas are attracted to one another by the force of gravity. Newtons law had a huge impact on how people thought about the universe. It explains the motion of objects not only on Earth but in outer space as well. You can learn more about Newtons law of gravity in the video at this URL: Newtons law also states that the strength of gravity between any two objects depends on two factors: the masses of the objects and the distance between them. Objects with greater mass have a stronger force of gravity. For example, because Earth is so massive, it attracts you and your desk more strongly than you and your desk attract each other. Thats why you and the desk remain in place on the floor rather than moving toward one another. Objects that are closer together have a stronger force of gravity. For example, the moon is closer to Earth than it is to the more massive sun, so the force of gravity is greater between the moon and Earth than between the moon and the sun. Thats why the moon circles around Earth rather than the sun. This is illustrated in Figure You can apply these relationships among mass, distance, and gravity by designing your own roller coaster at this URL: . Newtons idea of gravity can predict the motion of most but not all objects. In the early 1900s, Albert Einstein came up with a theory of gravity that is better at predicting how all objects move. Einstein showed mathematically that gravity is not really a force in the sense that Newton thought. Instead, gravity is a result of the warping, or curving, of space and time. Imagine a bowling ball pressing down on a trampoline. The surface of the trampoline would curve downward instead of being flat. Einstein theorized that Earth and other very massive bodies affect space and time around them
Question: SI unit for weight | [
"newton"
] | task469-a5f487446451417289af2b82a47cf3ef | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: Udayananu Tharam (English: Udayan Is the Star) is a 2005 Malayalam black comedy film directed by Rosshan Andrrews and co-written by Sreenivasan.
Question: Who was Udayananu Tharam directed by? | [
"sreenivasan"
] | task469-9dcb48fd7b764f06be856618bbce5245 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: Pittosporum viridulatum is a critically endangered species of plant in the Pittosporaceae family.
Question: What is the conservation status of Pittosporum viridulatum? | [
"critically endangered"
] | task469-8e1c3f4d558d4a6cb9892d36243e451e | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: The Wii U (/wi ju/ WEE EW) is a home video game console created by Nintendo and the successor to the Wii.
Question: Which is the manufacturer of Wii U? | [
"nintendo"
] | task469-79b574eef49a47c2abc93a751e821f9b | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: Cameron Howat (born 30 January 1985) is a former Australian rules footballer who was selected in the 2005 AFL Rookie Draft by the Richmond Football Club and delisted after the 2008 season.
Question: What was Cameron Howat's team? | [
"richmond football club"
] | task469-97b0477936de478e9c1dda8c77d3a220 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: Recent evidence suggests that abnormal activation of cyclin-dependent kinase 5 (cdk5) is a critical prodeath signal in stroke. However, the mechanism(s) by which cdk5 promotes death is unclear. Complicating the role of cdk5 are the observations that cdk5 can exist in multiple cellular regions and possess both prosurvival and prodeath characteristics. In particular, the critical role of cytoplasmic or nuclear cdk5 in neuronal jury, in vivo, is unclear. Therefore, we determined where cdk5 was activated in models of ischemia and how manipulation of cdk5 in differing compartments may affect neuronal death. Here, we show a critical function for cytoplasmic cdk5 in both focal and global models of stroke, in vivo. Cdk5 is activated in the cytoplasm and expression of DNcdk5 localized to the cytoplasm is protective. Importantly, we also demonstrate the antioxidant enzyme Prx2 (peroxiredoxin 2) as a critical cytoplasmic target of cdk5. In contrast, the role of cdk5 in the nucleus is context-dependent. Following focal ischemia, nuclear cdk5 is activated and functionally relevant while there is no evidence for such activation following global ischemia. Importantly, myocyte enhancer factor 2D (MEF2D), a previously described nuclear target of cdk5 in vitro, is also phosphorylated by cdk5 following focal ischemia. In addition, MEF2D expression in this paradigm ameliorates death. Together, our results address the critical issue of cdk5 activity compartmentalization, as well as define critical substrates for both cytoplasmic and nuclear cdk5 activity in adult models of stroke.
Question: What type of enzyme is peroxiredoxin 2 (PRDX2)? | [
"antioxidant"
] | task469-c565efaa018b463eb00fff1211d62173 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: All rocks on Earth change, but these changes usually happen very slowly. Some changes happen below Earths surface. Some changes happen above ground. These changes are all part of the rock cycle. The rock cycle describes each of the main types of rocks, how they form and how they change. Figure 4.1 shows how the three main rock types are related to each other. The arrows within the circle show how one type of rock may change to rock of another type. For example, igneous rock may break down into small pieces of sediment and become sedimentary rock. Igneous rock may be buried within the Earth and become metamorphic rock. Igneous rock may also change back to molten material and re-cool into a new igneous rock. Rocks are made of minerals. The minerals may be so tiny that you can only see them with a microscope. The minerals may be really large. A rock may be made of only one type of mineral. More often rocks are made of a mixture of different minerals. Rocks are named for the combinations of minerals they are made of and the ways those minerals came together. Remember that different minerals form under different environmental conditions. So the minerals in a rock contain clues about the conditions in which the rock formed (Figure 4.2). Geologists group rocks based on how they were formed. The three main kinds of rocks are: 1. Igneous rocks form when magma cools below Earths surface or lava cools at the surface (Figure 4.3). 2. Sedimentary rocks form when sediments are compacted and cemented together (Figure 4.4). These sediments may be gravel, sand, silt or clay. Sedimentary rocks often have pieces of other rocks in them. Some sedimentary rocks form the solid minerals left behind after a liquid evaporates. 3. Metamorphic rocks form when an existing rock is changed by heat or pressure. The minerals in the rock change but do not melt (Figure 4.5). The rock experiences these changes within the Earth. Rocks can be changed from one type to another, and the rock cycle describes how this happens. Any type of rock can change and become a new type of rock. Magma can cool and crystallize. Existing rocks can be weathered and eroded to form sediments. Rock can change by heat or pressure deep in Earths crust. There are three main processes that can change rock: Cooling and forming crystals. Deep within the Earth, temperatures can get hot enough to melt rock. This molten material is called magma. As it cools, crystals grow, forming an igneous rock. The crystals will grow larger if the magma cools slowly, as it does if it remains deep within the Earth. If the magma cools quickly, the crystals will be very small. Weathering and erosion. Water, wind, ice, and even plants and animals all act to wear down rocks. Over time they can break larger rocks into smaller pieces called sediments. Moving water, wind, and glaciers then carry these pieces from one place to another. The sediments are eventually dropped, or deposited, somewhere. The sediments may then be compacted and cemented together. This forms a sedimentary rock. This whole process can take hundreds or thousands of years. Metamorphism. This long word means to change form. A rock undergoes metamorphism if it is exposed to extreme heat and pressure within the crust. With metamorphism, the rock does not melt all the way. The rock changes due to heat and pressure. A metamorphic rock may have a new mineral composition and/or texture. An interactive rock cycle diagram can be found here: The rock cycle really has no beginning or end. It just continues. The processes involved in the rock cycle take place over hundreds, thousands, or even millions of years. Even though for us rocks are solid and unchanging, they slowly change all the time.
Question: any mixture of minerals in the solid state | [
"rock"
] | task469-8eea67e6c2454af7ac121c951f548fd4 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: Jack Elgin is the European editor of The Economist, which is based in London, England. Jack has a wife named Maria and three kids named Joanne, Julia, and Andrew. Jack subtly changes the family vacation from a lazy week of Mediterranean fun and sun in Corfu, Greece, to a tour of India, because of a story he has to cover. Maria is not as impressed by this as the kids are. Jack himself envisioned a chance to simultaneously work an easy reporting assignment and spend a little quality time with his family. But on the way to India, the airplane, a 747 owned by AM Air, an American airline, makes an unscheduled stopover in Limassol Cyprus, because of a mechanical problem. After a while of waiting inside the Limassol airport, everyone gets back on the plane -- which is then hijacked by a group of terrorists known as the August 15th Movement, led by a Serbian man named Ivanic Loyvek and his right-hand man Karadan Maldic. The terrorists take a silver briefcase from an diplomatic courier, an older man, and it appears to be an important object of their hijack. And they are demanding $50,000,000 from the US State Department in one hour, or everyone on the airplane will die.The demand is met, and Loyvek and Maldic start releasing the women and children, with the men to go last. But as soon as a front passenger door is opened, the local police begins shooting. Inside the plane, the owner of the briefcase retrieves it, only to be killed the terrorists, who take it again.The flight attendants frantically open the rest of the airplane's doors and start getting passengers out, but the terrorists start killing passengers, leading to an explosion. Maria, Joanne, and Julia get out of the airplane, and then Jack, holding Andrew, gets out -- only to watch Maria, Joanne, and Julia get shot by the terrorists. Jack tries to hide Andrew's face so he can't see. Maria and Joanne are killed, but Julia burns to death while crying for help.Jack and Andrew survive. 15 passengers die, and Loyvek and Maldic, the surviving terrorists, escape, knowing that they now have the $50,000,000. Back in London, a devastated Jack is told that the terrorists were captured, but they were released and deported secretly, with no charges and no arrest, the result of some awfully compromised politics. Jack is understandably enraged that Loyvek and Maldic got off scot-free. While helping Andrew cope, Jack tries all the legal ways to ensure justice for his family, but to no avail.Jack even pays a visit to Henry Davidson, a CIA agent who works at the American Embassy in London. Davidson tells Jack that there's little that can be done. The American and British governments are completely impotent when it comes to going after Loyvek and Maldic. Jack decides he has no choice in the matter but to seek revenge. With the help of his ex-intelligence operative friend Kate Stockton, who is well-schooled in the finer points of international intelligence, Jack becomes a one-man anti-terrorist squadron, searching for Loyvek and Maldich. He finds a warehouse they apparently are using as a headquarters. Breaking in, he finds some papers which he takes, and some weapons. The terrorists return, find a flashlight Jack was using, and begin searching the warehouse. Jack returns upstairs, retrieves a machine pistol and loads it with a magazine. He kills three terrorists before escaping.He later breaks into the home of a friend at MI6 and steals a Walther PPK pistol from his home. He shows up at a theatre and makes a scene at the bar, to be sure he is noticed by the bartender. He then follows one of the terrorists in his taxicab, killing him with that weapon. He returns to the theatre and makes a point of apologizing to the bartender. The next day he goes pheasant hunting with his MI6 contact in case he is tested for gunpowder residue.Dogging Jack's trail is FBI agent Jules Bernard, who's cooperating with Scotland Yard on anti-terrorist activities, and who suspects
Question: Who is Jack's wife? | [
"maria"
] | task469-93afb072103a4eaea1ed7540208c30c0 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: The officials of a city unveil a new statue, only to find The Tramp sleeping on it. They shoo him away and he wanders the streets, destitute and homeless, and is soon tormented by two newsboys. He happens upon a beautiful Flower Girl (Virginia Cherrill), not realizing at first that she is blind, and buys a flower. Just when she is about to give him his change, a man gets into a nearby luxury car and is driven away, making her think that the Tramp has departed. The Tramp tiptoes away. That evening, the Tramp runs into a drunken Millionaire (Harry Myers) who is attempting suicide on the waterfront. (It is later mentioned that his wife has sent for her bags.) The Tramp eventually convinces The Millionaire he should live. He takes the Tramp back to his mansion and gives him a change of clothes. They go out for a night on the town, where the Tramp inadvertently causes much havoc. Early the next morning, they return to the mansion and encounter the Flower Girl en route to her vending spot. The Tramp asks The Millionaire for some money, which he uses to buy all the girl's flowers and then drives her home in the Millionaire's Rolls-Royce.After he leaves, the Flower Girl tells her Grandmother (Florence Lee) about her wealthy acquaintance. When the Tramp returns to the mansion, the Millionaire has sobered and does not remember him, so has the butler order him out. Later that day, the Millionaire meets the Tramp again while intoxicated, and invites him home for a lavish party. The next morning, having sobered again and planning to leave for a cruise, the Millionaire again has the Tramp tossed out.Returning to the Flower Girl's apartment, the Tramp spies her being attended by a doctor. Deciding to take a job to earn money for her, he becomes a street sweeper. Meanwhile, the Grandmother receives a notice that she and the girl will be evicted if they cannot pay their back rent by the next day, but hides it. The Tramp visits the girl on his lunch break, and sees a newspaper story about a Viennese doctor who has devised an operation that cures blindness. He then finds the eviction notice and reads it aloud at the girl's request. He reassures her that he will pay the rent. But he returns to work late and is fired.As he is walking away, a boxer persuades him to stage a fake fight, promising to split the $50 prize money. Just before the bout, however, the man receives a telegram warning him that the police are after him. He flees, leaving the Tramp a no-nonsense replacement opponent. Despite a valiant effort, the Tramp is knocked out.Some time later, he meets the drunken Millionaire who has just returned from Europe. The Millionaire takes him to the mansion and after he hears the girl's plight, gives the Tramp $1,000. Unbeknownst to the Millionaire and the Tramp, two burglars were hiding in the house when they entered. Upon hearing about the cash, they knock out the millionaire and take the rest of his money. The Tramp telephones for the police, but the robbers flee before they arrive, and the butler assumes he stole the money. The Millionaire cannot remember the Tramp or giving him the $1,000. The Tramp narrowly escapes and gives the money to the girl saying he will be going away for a while. Later, he is arrested in front of the newsboys who taunted him earlier, and jailed.Months later, the Tramp is released. Searching for the girl, he returns to her customary street corner but does not find her. With her sight restored, the girl has opened up a flourishing flower shop with her Grandmother. When a rich customer comes into the shop, the girl briefly wonders if he is her mysterious benefactor. But when he leaves with no acknowledgement, she realizes again she is wrong. While retrieving a flower from the gutter outside the shop, the Tramp is again tormented by the two newsboys. As he turns to leave, he finds himself staring at the girl
Question: What does the Tramp find and read aloud to the Flower girl? | [
"an eviction notice"
] | task469-2c2abec20b004343b9a2fcb61fdd3666 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: Flatworms are invertebrates that belong to Phylum Platyhelminthes. There are more than 25,000 species in the flatworm phylum. Not all flatworms are as long as tapeworms. Some are only about a millimeter in length. Flatworms have a flat body because they lack a fluid-filled body cavity. They also have an incomplete digestive system with a single opening. However, flatworms represent several evolutionary advances in invertebrates. They have the following adaptations: Flatworms have three embryonic cell layers. They have a mesoderm layer in addition to ectoderm and endoderm layers. The mesoderm layer allows flatworms to develop muscle tissues so they can move easily over solid surfaces. Flatworms have a concentration of nerve tissue in the head end. This was a major step in the evolution of a brain. It was also needed for bilateral symmetry. Flatworms have bilateral symmetry. This gives them a better sense of direction than radial symmetry would. Watch this amazing flatworm video to learn about some of the other firsts these simple animals achieved, including being the first hunters: [Link] MEDIA Click image to the left or use the URL below. URL: Flatworms reproduce sexually. In most species, the same individuals produce both eggs and sperm. After fertilization occurs, the fertilized eggs pass out of the adults body and hatch into larvae. There may be several different larval stages. The final larval stage develops into the adult form. Then the life cycle repeats. Some flatworms live in water or moist soil. They eat invertebrates and decaying animals. Other flatworms, such as tapeworms, are parasites that live inside vertebrate hosts. Usually, more than one type of host is needed to complete the parasites life cycle, as shown in Figure 12.12. Roundworms are invertebrates in Phylum Nematoda. This is a very diverse phylum. It has more than 80,000 known species. Roundworms range in length from less than 1 millimeter to over 7 meters in length. You can see an example of a roundworm in Figure 12.13. Roundworms have a round body because they have a partial fluid-filled body cavity (pseudocoelom). This is one way that roundworms differ from flatworms. Another way is their complete digestive system. It allows them to eat, digest food, and eliminate wastes all at the same time. Roundworms have a tough covering of cuticle on the surface of their body. It prevents their body from expanding. This allows the buildup of fluid pressure in their partial body cavity. The fluid pressure adds stiffness to the body. This provides a counterforce for the contraction of muscles, allowing roundworms to move easily over surfaces. Roundworms reproduce sexually. Sperm and eggs are produced by separate male and female adults. Fertilization takes place inside the female organism. Females lay huge numbers of eggs, sometimes as many as 100,000 per day! The eggs hatch into larvae, which develop into adults. Then the life cycle repeats. Roundworms may be free-living or parasitic organisms. Free-living worms are found mainly in freshwater habitats. Some live in moist soil. They generally feed on bacteria, fungi, protozoa, or decaying organic matter. By breaking down organic matter, they play an important role in the carbon cycle. Parasitic roundworms may have plant, invertebrate, or vertebrate hosts. Several roundworm species infect humans. Besides ascaris, they include hookworms. Hookworms are named for the hooks they use to grab onto the hosts intestines. You can see the hooks in Figure 12.14. Hookworm larvae enter the host through the skin. They migrate to the intestine, where they mature into adults. Female adults lay large quantities of eggs. Eggs pass out of the host in feces. Eggs hatch into larvae in the feces or soil. Then the cycle repeats. You can learn more about parasitic roundworms in humans by watching this short video: . MEDIA Click image to the left or use the URL below. URL:
Question: How many eggs can a single roundworm lay in a day? | [
"as many as 100,000"
] | task469-6543a086c53c4acd9c05a21209ffbb91 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: In 1991, the governments of the U.S. and China are on the verge of a major trade agreement, with the President of the United States due to visit China to seal the deal. The CIA learns that its asset Tom Bishop (Brad Pitt) has been captured trying to free a Briton, Elizabeth Hadley (Catherine McCormack), from a People's Liberation Army prison in Su Chou near Shanghai, China. Bishop is being questioned under torture and will be executed in 24 hours unless the U.S. government claims him. If the CIA claims Bishop as an agent, they risk jeopardizing the trade agreement. Exacerbating Bishop's situation is the fact that he was operating without permission from the Agency. Attempting to deal quickly with the situation, CIA executives call in Nathan Muir (Robert Redford), an aging mid-level case officer on his last day before retirement and the man who recruited Bishop. Although they tell Muir they simply need him to act as a "stop gap" to fill in some holes in their background files, the officials are hoping he will give them the pretext they need to justify letting Bishop die. The CIA executives are unaware that Muir had been tipped off about Bishop's capture prior to arriving at the CIA's headquarters, by fellow CIA veteran Harry Duncan (David Hemmings), for whom Bishop had been working an operation in Hong Kong before going rogue. Muir first attempts to save Bishop by leaking the story to CNN through a contact in Hong Kong, believing that public pressure would force the CIA to rescue Bishop. The tactic only stalls them, however, and is stymied when a phone call to the U.S. Federal Communications Commission from CIA Deputy Director Charles Harker (Stephen Dillane) results in CNN retracting the story. During the debriefing, Muir describes how he recruited Bishop for an operation when Bishop was a U.S. Marine scout sniper during the Vietnam War. Muir also discusses their 1976 tour of duty in Berlin, Germany, where Bishop was tasked with procuring East German assets, with Muir commanding, as well as Bishop's spy work in Beirut, Lebanon in 1985 during the War of the Camps, the latter being the last time the two saw each other. During the mission in Lebanon, Bishop met Hadley, and the two began developing romantic feelings for each other. However, it is revealed that Hadley was involved in a bombing of the Chinese embassy in Britain, causing her to flee the country. Fearing that Bishop's feelings for Hadley might compromise his cover and the mission, Muir tips off the Chinese to Hadley's location in return for freeing an arrested U.S. diplomat. Chinese agents kidnap Hadley, and Bishop cuts all ties to Muir when he discovers his involvement. After learning Hadley was the target of Bishop's rescue attempt, Muir finally realizes that he has greatly underestimated Bishop's feelings for her. Running out of time, Muir secretly creates a forged urgent operational directive from the CIA director to commence Operation Dinner Out, a rescue mission to be spearheaded by Commander Wiley's (Dale Dye) U.S. Navy SEAL team, for which Bishop had laid the groundwork as a "Plan B" for his own rescue attempt. Using US$282,000 of his life savings and a misappropriated file on Chinese coastline satellite imagery, Muir enlists Duncan's help in bribing a Chinese energy official to cut power to the prison for 30 minutes, during which time the SEAL rescue team retrieves Bishop and Hadley. Bishop, who is rescued at the end of the film 15 minutes before his scheduled execution, realizes Muir was behind his rescue when he recognizes the name of the plan to rescue him, Operation Dinner Out: a reference to a birthday gift that Bishop gave Muir while they were in Lebanon. When the CIA officials are belatedly informed of the rescue, Muir has already left the building and is seen driving off into the countryside.
Question: Whats the name of the English woman? | [
"elizabeth hadley"
] | task469-9393611a2b4249ebb57ec2b7706f7aba | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: In Egypt, circa 1290 BC, high priest Imhotep engages in an affair with Anck-su-Namun, the mistress of Pharaoh Seti, despite strict rules that other men are forbidden to touch her. When the Pharaoh discovers their tryst, Imhotep and Anck-su-Namun murder the monarch. Imhotep is dragged away by his priests before the Pharaoh's guards can discover his involvement; Anck-su-Namun then kills herself, intending for Imhotep to resurrect her. After Anck-su-Namun's burial, Imhotep breaks into her crypt and steals her corpse. He and his priests flee across the desert to Hamunaptra, the City of the Dead, where they begin the resurrection ceremony. However, they are caught by Seti's guards before the ritual could be completed, and Anck-su-Namun's soul is sent back to the Underworld. For their sacrilege, Imhotep's priests are mummified alive, and Imhotep himself is forced to endure the curse of Hom Dai: his tongue is cut out and he is buried alive with a swarm of flesh-eating scarabs. The ritual curses him to become an immortal walking plague if he were ever to be resurrected. He is buried under high security, sealed away in a sarcophagus below a statue of the Egyptian god Anubis, and kept under strict surveillance throughout the ages by the Medjai, descendants of Seti's palace guards. If Imhotep were ever to be released, the powers that made him immortal would allow him to unleash a wave of destruction and death upon the Earth.In 1923, soldiers from the French Foreign Legion, led by American Rick O'Connell, make a final stand at Hamunaptra against an overwhelming force of Medjai warriors. The soldiers are massacred and O'Connell makes a final retreat inside the city, only to be cornered by a group of Medjai. However, they flee when Imhotep's evil presence manifests itself, leaving him to die in the desert.In 1926, Cairo librarian and aspiring Egyptologist, Evelyn Carnahan is presented with an intricate box and map by her bumbling brother Jonathan, who says he found it in Thebes. The map seems to point the way to the lost city of Hamunaptra, where all of the wealth of Egypt was supposedly stored; however, the museum curator, Dr. Bey, dismisses Hamunaptra as a myth, and accidentally damages the map. Jonathan reveals he actually stole it from an American (revealed to be O'Connell), who is currently in prison, and may be able to tell more about Hamunaptra. Rick tells them that he knows the location of the city from his days in the Foreign Legion. He makes a deal with Evelyn to reveal the location of Hamunaptra, in exchange for Evelyn saving Rick from being hanged. Evelyn successfully negotiates his release from the prison warden by offering him 25% of the found treasure; however, the warden insist on coming along in order to protect his investment. They board a ship to start their expedition to the city, where they encounter a band of American treasure hunters led by the famed Egyptologist Dr. Allen Chamberlain, and guided by Beni Gabor, a cowardly former Legion soldier who served with Rick and also knows the location of the lost city.During the journey, the boat is invaded by Medjai soldiers who are looking for Evelyn's box and the map. The expedition manages to fight them off, but the map is lost and the boat goes up in flames, forcing the entire party to go ashore. Rick, Evelyn and Jonathan are separated from the other treasure hunters and procure camels at a nearby market. Since Rick knows the way to the city, they arrive at Hamunaptra at the same time as the other party, but due to tensions between the two groups, they start exploring the city in separate locations. The Americans discover a chest between the legs of the statue of Anubis. They have it opened by several of their carriers, but the chest is booby-trapped and the carriers die from an acid spray. In the meanwhile, Evelyn is looking for the Book of Amun-Ra, a solid gold book supposedly capable of taking life away. Her team discovers a tomb buried directly below the statue of Anubis
Question: Who calls Helen back to the world of the living? | [
"frank",
"imhotep"
] | task469-6be777bd1763483eadb418ea759eedfc | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: Salvador Sanchez Ceren (born 18 June 1944) is a Salvadoran politician and the current President of El Salvador.
Question: Which was the position that Salvador Sanchez Ceren held? | [
"president of el salvador"
] | task469-ba1b15ee7d604bfeb747a8b487d75c9f | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: Sightseeing Tours in Germany Germany has a variety of cities each with its own characteristics, from the busy city of Berlin, to the ancient city of Cologne, to the Bavarian capital of Munich. Thankfully, these major German cities offer sightseeing tours that offer the opportunity to better explore the surrounding regions and the country's most historic sites. Berlin on Bike Berlin on Bike takes visitors through the German capital via five bicycle tours, all with guides. Regular tours include the Wall Tour and Berlin's Best, with stops at some of the city's most famous landmarks, such as the Reichstag explores what life was like in East Berlin under Communist Rule. The cost of the tour includes the bike and helmet rental, and tourists may choose to continue renting their bikes once the tour has ended. Berlinonbike.de/English/index.php Munich City Sightseeing Tour The Munich City Sightseeing Tour transports travelers throughout the city via an open-air, double-decker bus. Passengers can hop on and off at various stops throughout the day. This tour includes stops at such sites as the Munich central train station, the 1972 Olympic Stadium Park, Munich's opera house and Karlsplatz, the gate to the historic city. The bus features a narrated tour guide and offers an English-language option. Raileurope.com/activities/munich-city-sightseeing-tour/index.html Nice City Tours- Cologne Nice City Tours offers three tours of Cologne, available to private or business groups in a variety of languages. The old Town Tour runs for two hours and includes a guided tour of the Cologne Cathedral and some of the city's old squares. The Brewery Pub Tour explores some of the city's most beloved breweries and pubs, and details the history behind Kolsch, Cologne's resident beer. Finally, the Old Town and Rhine Tour begins by visiting some of old town's most historic sites and ends with a ride down the Rhine River. Nicecitytours.con/tours.htm
Question: If you take a great interest in beer, which tour might be suitable for you? | [
"the brewery pub tour"
] | task469-a986fff4b0294c90ba4ea2ac1094a672 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: The modern world is full of useful objects that were invented by someone, from spoons and chopsticks in our kitchens to the Ipads in our handbags. Each invention is an example of the creative power of the human mind. Where do inventors get their inspirations ? The inspiration behind each of these inventions varies. Take the shopping cart as an example. Sylvan Goldman was a grocery store owner. Like most businessmen, he wished that his customers would buy more so that he could make more money. He knew what if they could carry more goods easily as they were shopping, when his sales would go up. While thinking about the problem one night, he had an idea. Working with a local handyman named Fred Young, he designed the first shopping cart. Today, retailers who use shopping carts sell more goods and make more profits. Nature has also inspired inventors throughout history. This is what happened to George de Mestral one day. While hunting with his dog in the Swiss Alps, he noticed how the burs of certain plants stuck to his clothing and to his dog' s fur. After examining them under a microscope, he found they had tiny hooks that could easily stick to the fibers of clothing or animal hide. For the next ten years, George de Mestral searched for the hest way to produce his idea. The result of his original inspiration was Velcro, which is used in many modem objects, including sportswear, shoes, automobiles, and even space suits. These examples show us that there are at least two possible inspirations for human creativity in the world of inventions -- profit and nature. No doubt, the future will continue to breathe new life into the economies of the world with fresh ideas and inventions. How many of their creations will be inspired by natural phenomena? The world's problems require creativity and we can expect best solutions from future generations.
Question: According to the article, which invention shows how nature inspires us? | [
"velcro."
] | task469-f920b499ab554d5a977eff98a45ef7e4 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: Reactive oxygen species are involved in ovulation. The aim of this study was to examine gonadotropin regulation of antioxidant enzyme sulfiredoxin (Srx) and peroxiredoxin 2 (PRDX2) expressions and modification during the ovulatory process in rats. Administration of antioxidants in vivo reduced ovulation rate and cumulus expansion. LH treatment increased H(2)O(2) levels within 15 min, which, in turn, induced Srx gene expression in cultured preovulatory follicles. Treatment of preovulatory follicles with catalase suppressed the stimulatory effect of LH on Akt phosphorylation. LH- or H(2)O(2)-stimulated Srx mRNA levels were suppressed by inhibitors of antioxidant agents and MAPK kinase. An in vivo injection of equine chorionic gonadotropin-human chorionic gonadotropin (hCG) stimulated Srx mRNA within 1 h in granulosa but not thecal cells of preovulatory follicles. Srx protein levels were stimulated from 3 h post-hCG injection. Immunofluorescence analysis revealed that oocytes expressed the Srx protein. Furthermore, hCG treatment increased Srx expression in mural granulosa, theca and cumulus cells, but the Srx protein was not detected in corpora lutea. Gene expression of PRDX2, identified as an Srx-dependent modified enzyme, was stimulated by gonadotropins. In situ hybridization analysis demonstrated that PRDX2 mRNA was detected in oocytes and theca cells as well as granulosa cells of some antral and preovulatory follicles. High levels of PRDX2 mRNA were detected in corpora lutea. Total levels of PRDX2 protein were not changed by gonadotropins. However, levels of hyperoxidized PRDX2 increased within 2-3 h after the hCG injection. Taken together, gonadotropin stimulation of Srx expression and PRDX2 modification in the ovary suggest the existence of an antioxidant system to maintain H(2)O(2) production and elimination during the periovulatory period.
Question: What type of enzyme is peroxiredoxin 2 (PRDX2)? | [
"antioxidant"
] | task469-5490846bb0204a9faa8f0571f4dad16c | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: Joanna of Julich (died 1394) was the youngest daughter of Duke William II and his wife, Marie of Guelders.
Question: Who is Joanna of Julich's mother? | [
"marie of guelders"
] | task469-4fa217f0e65d44efaa8de32597773e8f | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: Saturday, October 8, 120 miles northeast of Blainsworth, Nebraska; 1:16 p.m.Bob Irisin, a metrologist for the Kansas City weather bureau, is riding in his Bronco truck when he stops and radios to his friend Stan in Kansas City, that he is witnessing a sudden change in weather patterns in the area. Then a tornado suddenly touches down near a farm where Bob sees a family of a man, woman and their little girl standing in front of the house, unaware of the tornado approaching behind them. Bob drives as near as he can go and manages to yell out a warning to the family seconds before they see the twister coming. The family runs into their storm shelter just in time before the twister destroys their house. Bob drives away from harms way just in time.Meanwhile, in Blainsworth, there is the annual fall Bike-a-thon race for the high school kids. 13-year-old Dan Hatch gets a flat tire and doesnt come in at all. Dans stern father, Jack, is arguing with a banker who's asking to foreclose on his hardware shop since a new mall has opened in the nearby town. Jack refuses to sell the shop at any price. Dan walks his bike into the town square where his best friend, Arthur, talks with him about getting "crashed and burned" during the race. Jack walks over and becomes hard on Dan for not finishing the race like a man should. Dan yells at his father for being so demanding and that he can't expect anything from anyone. Dan's mother, Laura, with her new baby Ryan and her friend Jenny, walk by and never less tell him he did okay anyway. Just then, Dan is called to the square podium for he is has been chosen by a lottery to be the winner of a new Schwinn Voyager bicycle, much to his father and mother's delight.75 miles northeast of Blainsworth; 3:37 p.m. Bob sits in his Bronco truck and radios in of rogue weather patterns, while observing another tornado rip through a nearby trailer park. Bob tells Stan that the front is moving south instead of north and the atmospheric activity is the most bizarre he has ever seen. Bob decides to travel to Blainsworth to see if anything will happen.Outside of Blainsworth, Dan and Arthur sit in the woods looking up at the clear sky. Dan tell Arthur about his fathers demanding which is a driving force that he cant stand. Then Arthur's two younger sisters, Stacey and Ronnie Vae, appear and want Arthur to come home since their parents are out of town for the weekend. Arthur and Dan watch as clouds begin to roll in and they decide to get indoors. At Arthurs house, the boys play a game of pool, in which Dan forgets he's suppose to take his grandmother's dog for a walk.Six miles northeast of Blainsworth 4:30 p.m.; Dan arrives at his grandmother Goldie's house where his father is already there taking her dog to the vet, for it has a bad leg. Jack yells at Dan for not being responsible for anything, and Dan rides on his new bike home.Arthur arrives at the Hatch house, were Laura is getting ready to leave for work for the evening. Jenny arrives at the house to pick Laura up, were they talk about Jack being so domineering on Dan for he doesn't want Dan to end up a loser like him.Nightfall. Arthur and Dan play with musical instruments, while checking every few minutes if baby Ryan in the next room is all right. Jack then arrives and tells Dan and Arthur to bring their bicycles in for its raining. Going out, they find that its raining hard and the winds are picking up speed. Arthur tells Dan that since hes originally from Los Angeles, he enjoys the rain, while Dan sees little amusement in it, for he tells Arthur that rain and hailstorms can get bad.At the local diner in town, Laura is waitressing when Bob walks in asking for some coffee. Bob overhears a farmer named Gus talk about the storm and of tornados reported in the area. Bob tells Gus that most people killed by tornados
Question: Who was the station wagon loaned to? | [
"jack"
] | task469-450207e70de04382b3fb8c9740abc2f4 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: Space wizard hires interplanetary mercenaries to kidnap alien smurf rock stars. Said rock stars are held captive using brainwashing, cognitive implants, and cosmetic surgery; guarded by cyborgs. Super fan-boy jumps into his space guitar and follows mercenaries to Earth, and lives amongst the downtrodden as he waits for a chance to rescue them. Chance comes in a super concert funded by the space wizard, in which the fan-boy glides down in a jet glider and shoots cognitive implants off the alien smurf rock stars. All but the female are saved and the band runs off, (Space wizard holds up a super arm to block the shot of the fan-boy, and keeps the device from being William Tell'd off of her). As the band escapes they are pursued and shot at by the cyborgs. A stray lazer bullet is deflected by one of the aliens, and hits the fan-boy. Cyborgs can't drive and run into a semi, kersploding their car, and causing them to survive all Terminator style. The female is then whisked away and forced to dress pretty at various events. She is saved by the rock stars while the artists of the soundtrack are defeated in musical kombat. Being taken to their alien hideout, she is introduced to the fan-boy, and he shows off toys of their alien smurf rock star selves. Alien smurf rock stars are all WTF, and his psychotropic blood causes a hallucination, in which he and the female trip out and shows what a date would have been like (enter best song on the album). Fan-boy dies, and sadness ensues. They go out into the world, free from the space wizard, and bury the fan-boy under a tree. Fan-boy evolves into naked ghost fan-boy. Driving along she finds a clear card invitation to an address not far from where they are. The go inside and discover it's the space wizards house. Inside they find the story of the space wizard, and realize he's all super evil, and old. They are captured, and taken to the basement, where they find the machine he was going to use to gain control of the universe. Placing the female into the machine, as well as their number one gold record, (the one they defeated the soundtrack artists with), the space wizard prepares to He-man it up. Luckily the rest of the band fights back and overpowers their old cyborg guards, causing the space wizard to fall down a big hole, and them to be able to escape. They learn where their old identities are, and send the black guy in to steal them back for everyone. He's stopped by the security guards of the building the identity discs are in, and hospitalized. He re-blues, and the nice record exec helps him and the rest of the band to find out who they are. The people of Earth love the alien smurf rock stars, and send them to space. As they are going through the wormhole (no Morgan Freeman) they are attacked by a pissed off space wizard spirit. Naked ghost fan-boy counter attacks, and defeats the space wizard in immortal kombat. Alien smurf rock stars make it to their part of space, but being alien smurf rock stars, and not smurfstronauts, they don't know where to go. They say "fuck this" and proceed to do the only thing they know how to do, and rock out. Alien smurf space traffic control overhears their jam session, and go to rescue them. Happiness reigns supreme.
Question: Why the band travel backs to the record company? | [
"earth"
] | task469-dafb43b7df324b5c9c82f13acd4e7abb | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: Rose Elliot (Irene Miracle), a poet living alone in New York City, discovers an ancient book called The Three Mothers. It tells of the existence of three evil sisters who rule the world with sorrow, tears, and darkness. The book, written by an architect named Varelli, reveals that the three dwell inside separate homes that had been specially designed and built for them by the architect in Rome, Freiburg, and New York. Rose suspects that she is living in one of the buildings and writes to her brother Mark (Leigh McCloskey), a music student in Rome, urging him to visit her. Using clues provided in Varelli's book as a guide, Rose searches the cellar of her building and discovers a hole in the floor which leads to a water-filled ballroom. After accidentally dropping her keys into the water, she enters the flooded room. Swimming under the surface, she sees a portrait bearing the words "Mater Tenebrarum" and is able to reclaim the keys. A putrid corpse suddenly rises from the depths, frightening her. She escapes, although a shadowy figure watches her leave the basement.In Rome, Mark attempts to read Rose's letter during class. He is distracted by the intense gaze of a beautiful student (Ania Pieroni). When the class ends she leaves suddenly; Mark follows, leaving the letter behind. His friend Sara (Eleonora Giorgi) picks up the letter, and eventually reads it. Horrified by the letter's contents, she takes a taxi to a library and locates a copy of The Three Mothers. While looking for an exit, Sara is attacked by a monstrous figure who recognizes the book. She throws the book to the ground and escapes. Later that night, she seeks the company of a neighbor named Carlo (Gabriele Lavia) and both are stabbed to death by a gloved killer. Mark discovers the bodies and two torn fragments from Rose's letter. After the police arrive, he walks out of Sara's apartment and sees a taxi slowly driving by. In it is the music student, staring at him intently once again.Mark telephones Rose but is unable to hear her clearly. He promises to visit just before the connection fails. Cut off, Rose sees two shadowy figures preparing to enter her apartment. She leaves through a back door, but is followed. In a decrepit room, she is grabbed from behind by a clawed assailant and brutally murdered.Upon arriving in New York, Mark meets some of the residents of Rose's building, including a nurse (Veronica Lazar) who is caring for the elderly Professor Arnold (Feodor Chaliapin, Jr.), a wheelchair-bound mute. Mark learns from the sickly Countess Elise (Daria Nicolodi) that Rose has disappeared. Elise explains how Rose had been acting strangely. After the two find blood on the carpet outside Rose's room, Mark follows the stains. He suddenly becomes ill and falls unconscious. Elise sees a black-robed figure dragging Mark away, but the figure suddenly stops and gives chase to Elise. She is attacked by dozens of cats, who bite and claw at her flesh. The hooded figure then stabs her to death. Mark staggers to the house's foyer where the nurse and caretaker (Alida Valli) put him to bed.The next day, Mark asks Kazanian (Sacha Pitoeff), the antique dealer who sold Rose the Three Mothers book, about Rose. However, the man provides no information. That night, Kazanian drowns several cats in a Central Park pond and accidentally falls into the water. Hundreds of rats from a nearby drain crawl all over him, gnawing his flesh. A hot dog vendor hears Kazanian's cries and rushes over. The man kills Kazanian with a knife.Carol, the caretaker, discovers the horribly mutilated corpse of Elise's butler (Leopoldo Mastelloni) in the Countess' apartment. Shocked, she drops a lit candle which starts a fire. Attempting to put out the flames, she becomes entangled in burning draperies and falls from a window to her death.Meanwhile, Mark uses a clue from Rose's letter to discover that beneath each floor is a secret
Question: Who is Rose grabbed by? | [
"clawed assailant"
] | task469-f13b0574e2194579ab94ac140266b457 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: The son of Sir William James Bull, MP (1863--1931), who was created a Baronet in 1922, and his wife Lillian Hester Brandon, Anthony Bull was educated at Gresham's School, Holt (1922--1926), and Magdalene College, Cambridge (1926--1929).
Question: What is the name university that educated Anthony Bull? | [
"magdalene college"
] | task469-636af9b5e65b4da08dc08314dfbdafbd | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: In the county, the population was spread out with 23.5% under the age of 18, 7.8% from 18 to 24, 28.5% from 25 to 44, 25.9% from 45 to 64, and 14.2% who were 65 years of age or older. The median age was 40 years. For every 100 females, there were 93.8 males. For every 100 females age 18 and over, there were 90.5 males.
Question: Were there more of the population aged 65 and older or between age 45 to 64? | [
"from 45 to 64"
] | task469-378ec579f12d47fd859ee1ba4a1b5c23 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: In a few states where racial prejudice is serious, violence has so come to be taken for granted as a means of solving differences, that it is not even questioned. There are states where the white man imposes his rule by force; there are states where the black man protests by setting fire to cities and by looting and pillaging. Important people on both sides, who would in other respects appear to be reasonable men, get up and calmly argue in favor of violence - as if it were a legitimate solution, like any other. What is really frightening, what really fills you with despair, is the realization that when it comes to the crunch, we have made no actual progress at all. We may wear collars and ties instead of war-paint, but our instincts remain basically unchanged. The whole of the recorded history of the human race, that tedious documentation of violence, has taught us absolutely nothing. We have still not learnt that violence never solves a problem but makes it more serious. The sheer horror, the bloodshed, the suffering mean nothing. No solution ever comes to light the morning after when we dismally contemplate the smoking ruins and wonder what hit us. The truly reasonable men who know where the solutions lie are finding it harder and harder to get a hearing. They are despised, mistrusted and even persecuted by their own kind because they advocate such apparently outrageous things as law enforcement. If half the energy that goes into violent acts were put to good use, if our efforts were directed at cleaning up the shabby houses at improving living-standards and providing education and employment for all, we would have gone a long way to arriving at a solution. Our strength is weakened by having to mop up the mess that violence leaves in its wake. In a well-directed effort, it would not be impossible to fulfill the ideals of a stable social programme. The benefits that can be derived from constructive solutions are everywhere apparent in the world around us. Genuine and lasting solutions are always possible, providing we work within the framework of the law. Before we can even begin to reflect on peaceful co-existence between the races, we must appreciate each other's problems. And to do this, we must learn about them: it is a simple exercise in communication, in exchanging information. "Talk, talk, talk," the advocates of violence say, "all you ever do is talk, and we are none the wiser." It's rather like the story of the famous lawyer who carefully explained his case to the judge. After listening to a lengthy argument the judge complained that after all this talk, he was none the wiser. "Possible, my lord," the lawyer replied, "none the wiser, but surely far better informed." Knowledge is the necessary prerequisite to wisdom: the knowledge that violence creates the evils it pretends to solve.
Question: According the author the best way to solve race prejudice is | [
"law enforcement."
] | task469-cdfdfe66c3ed4e369f4a758ff2920cb5 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: A solar eclipse occurs when the new Moon passes directly between the Earth and the Sun (Figure 1.1). This casts a shadow on the Earth and blocks Earths view of the Sun. A total solar eclipse occurs when the Moons shadow completely blocks the Sun (Figure 1.2). When only a portion of the Sun is out of view, it is called a partial solar eclipse. Solar eclipses are rare and usually only last a few minutes because the Moon casts only a small shadow (Figure 1.3). As the Sun is covered by the Moons shadow, it will actually get cooler outside. Birds may begin to sing, and stars will become visible in the sky. During a solar eclipse, the corona and solar prominences can be seen. A solar eclipse occurs when the Moon passes between Earth and the Sun in such a way that the Sun is either partially or totally hidden from view. Some people, including some scientists, chase eclipses all over the world to learn or just observe this amazing phenomenon. A solar eclipse shown as a series of pho- tos. Click image to the left or use the URL below. URL: A lunar eclipse occurs when the full moon moves through Earths shadow, which only happens when Earth is between the Moon and the Sun and all three are lined up in the same plane, called the ecliptic (Figure 1.4). In an eclipse, Earths shadow has two distinct parts: the umbra and the penumbra. The umbra is the inner, cone-shaped part of the shadow, in which all of the light has been blocked. The penumbra is the outer part of Earths shadow where only part of the light is blocked. In the penumbra, the light is dimmed but not totally absent. A total lunar eclipse occurs when the Moon travels completely in Earths umbra. During a partial lunar eclipse, only a portion of the Moon enters Earths umbra. Earths shadow is large enough that a lunar eclipse lasts for hours and can be seen by any part of Earth with a view of the Moon at the time of the eclipse (Figure 1.5). A lunar eclipse does not occur every month because Moons orbit is inclined 5-degrees to Earths orbit, so the two bodies are not in the same plane every month.
Question: the inner, cone-shaped part of the shadow, in which all of the light has been blocked. | [
"umbra"
] | task469-7e58722d6ee8462da2fe3eff6e2b68a5 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: The Quarrymen (also written as ''the Quarry Men'') are a British skiffle/rock and roll group, formed by John Lennon in Liverpool in 1956, which eventually evolved into the Beatles in 1960.
Question: From what city is the band The Quarrymen? | [
"liverpool"
] | task469-155078b66e3f41389e5e6df566a0c4c2 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: Henoch-Schonlein purpura (HSP) is the most common form of childhood vasculitis. Various viral and bacterial infections, drugs, vaccines, food allergy and even insect bites have been considered as triggering factors in pathogenesis of HSP. Epstein-Barr virus (EBV) infection, which is associated with HSP, have been rarely reported. Herein we present HSP patient possibly caused by EBV infection. A 8-year old boy was admitted to our department with fever, rashes on legs and arms and intermittent mild abdominal pain. Multiple purpuric rashes were on his extremities, abdomen and buttock. Laboratory investigations revealed that monospot test was positive, EBV serology tests; Anti-EA-D Ig G: 3+, Anti-VCA gp125 Ig G: 3+, Anti-VCA p19 Ig M: 2+, Anti EBNA-1 Ig M: negative, Anti EBNA-1 Ig M: negative, Anti EBNA-1 Ig G: negative. The patient was interpreted as the primary active acute EBV infection. A skin biopsy showed leucocytoclastic vasculitis. The other viral and bacterial investigations were negative. The patient was diagnosed as HSP vasculitis according to EULAR criteria and treated with intravenous hydration and ibuprofen. He was discharged after 15 days with normal laboratory findings and physical examination. We think that EBV infection may be stimulant factor for autoimmune reactions and may cause HSP vasculitis. Hence, it may be useful to investigate the EBV infection in etiology of HSP cases.
Question: Which virus can be diagnosed with the monospot test? | [
"epstein-barr virus"
] | task469-3ce3e83b4db940e7bce3ddbe92ed6b10 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: Josef Barta, also Josef Bartha, (1744 in Prague - 13 June 1787 in Vienna ) was a Czech composer.
Question: Where did Josef Barta live when he died? | [
"vienna"
] | task469-cbfc88139a644f23bb446122752c68d4 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: Many life science discoveries would not have been possible without the microscope. For example: Cells are the tiny building blocks of living things. They couldnt be discovered until the microscope was invented. The discovery of cells led to the cell theory. This is one of the most important theories in life science. Bacteria are among the most numerous living things on the planet. They also cause many diseases. However, no one knew bacteria even existed until they could be seen with a microscope. The invention of the microscope allowed scientists to see cells, bacteria, and many other structures that are too small to be seen with the unaided eye. It gave them a direct view into the unseen world of the extremely tiny. You can get a glimpse of that world in Figure 1.10. The microscope was invented more than four centuries ago. In the late 1500s, two Dutch eyeglass makers, Zacharias Jansen and his father Hans, built the first microscope. They put several magnifying lenses in a tube. They discovered that using more than one lens magnified objects more than a single lens. Their simple microscope could make small objects appear nine times bigger than they really were. In the mid-1600s, the English scientist Robert Hooke was one of the first scientists to observe living things with a microscope. He published the first book of microscopic studies, called Micrographia. It includes wonderful drawings of microscopic organisms and other objects. One of Hookes most important discoveries came when he viewed thin slices of cork under a microscope. Cork is made from the bark of a tree. When Hooke viewed it under a microscope, he saw many tiny compartments that he called cells. He made the drawing in Figure 1.11 to show what he observed. Hooke was the first person to observe the cells from a once-living organism. In the late 1600s, Anton van Leeuwenhoek, a Dutch lens maker and scientist, started making much stronger microscopes. His microscopes could magnify objects as much as 270 times their actual size. Van Leeuwenhoek made many scientific discoveries using his microscopes. He was the first to see and describe bacteria. He observed them in a sample of plaque that he had scraped off his own teeth. He also saw yeast cells, human sperm cells, and the microscopic life teeming in a drop of pond water. He even saw blood cells circulating in tiny blood vessels called capillaries. The drawings in Figure 1.12 show some of tiny organisms and living cells that van Leeuwenhoek viewed with his microscopes. He called them animalcules. These early microscopes used lenses to refract light and create magnified images. This type of microscope is called a light microscope. Light microscopes continued to improve and are still used today. The microscope you might use in science class is a light microscope. The most powerful light microscopes now available can make objects look up to 2000 times their actual size. You can learn how to use a light microscope by watching this short video: http MEDIA Click image to the left or use the URL below. URL: To see what you might observe with a light microscope, watch the following video. It shows some amazing creatures in a drop of stagnant water from an old boat. What do you think the creatures might be? Do they look like any of van Leeuwenhoeks animalcules in Figure 1.12? MEDIA Click image to the left or use the URL below. URL: For an object to be visible with a light microscope, it cant be smaller than the wavelength of visible light (about 550 nanometers). To view smaller objects, a different type of microscope, such as an electron microscope, must be used. Electron microscopes pass beams of electrons through or across an object. They can make a very clear image that is up to 2 million times bigger than the actual object. An electron microscope was used to make the image of the ant head in Figure 1.10.
Question: __________type of microscope that uses lenses to refract visible light | [
"light microscope"
] | task469-5e3ccecec7544074bd70dcce2bf34670 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: The tumorigenesis of sporadic endocrine tumors is still not fully understood. It is well known that patients with von Recklinghausen syndrome (NF-1) (OMIM 162200) carrying NF1 germline mutations are predisposed to endocrine tumors including pheochromocytomas and duodenal somatostatinomas. It is unclear, however, whether the rarely reported occurrence of pancreatic insulinomas in NF-1 patients represents a coincidental finding or whether insulinomas are a rare manifestation of the NF-1 syndrome. To determine the potential association between the NF-1 syndrome and pancreatic endocrine tumors, we analyzed a NF-1 patient with a well-differentiated pancreatic endocrine carcinoma for NF1 mutation, allelic loss of the NF1 gene and its expression in peripheral blood and tumor cells. The germline mutation c. 499 del TGTT known in the family was confirmed by polymerase chain reaction (PCR) and direct sequencing of exon 4 in DNA extracted from peripheral blood. Loss of heterozygosity (LOH) analysis of the NF1 gene was carried out using 3 intragenic microsatellite markers on 17q11.2. RNA expression was examined by reverse transcription and a consecutive PCR spanning intron 3 of the NF1 gene including the mutated site in exon 4. Immunohistochemistry was used to analyze NF-1 protein expression. Mutation analysis of peripheral blood leukocytes confirmed the 4 base pair deletion in exon 4 starting at codon 167 (499 del TGTT). LOH analysis of tumor tissue revealed retention of both NF1 alleles. While reverse transcriptase-PCR of peripheral blood showed bi-allelic expression of both the wild-type NF1 and the mutated form, reverse transcriptase-PCR of tumor extracts demonstrated expression of the mutated but not the wild-type NF1 allele. Additionally, neurofibromin, the NF1 gene product, was absent in the tumor tissue of the NF-1 patient. These results show that the wild-type NF1 transcrips and protein are reduced, in the reported insulinoma, supposedly by epigenetic mechanisms. This provides strong evidence that there is a relationship between von Recklinghausen disease and the patient's insulinoma. In this line, insulinomas may be viewed as a rare manifestation of the NF-1 syndrome. Furthermore, the NF1 gene must be considered as a candidate tumor suppressor gene for sporadic insulinomas and probably other pancreatic endocrine tumors.
Question: Which is the gene mutated in type 1 neurofibromatosis? | [
"nf1"
] | task469-8256ffc6af4d49218c212014004e3bea | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: The discovery of the Hippo pathway can be traced back to two areas of research. Genetic screens in fruit flies led to the identification of the Hippo pathway kinases and scaffolding proteins that function together to suppress cell proliferation and tumor growth. Independent research, often in the context of muscle biology, described Tead (TEA domain) transcription factors, which bind CATTCC DNA motifs to regulate gene expression. These two research areas were joined by the finding that the Hippo pathway regulates the activity of Tead transcription factors mainly through phosphorylation of the transcriptional coactivators Yap and Taz, which bind to and activate Teads. Additionally, many other signal transduction proteins crosstalk to members of the Hippo pathway forming a Hippo signal transduction network. We discuss evidence that the Hippo signal transduction network plays important roles in myogenesis, regeneration, muscular dystrophy, and rhabdomyosarcoma in skeletal muscle, as well as in myogenesis, organ size control, and regeneration of the heart. Understanding the role of Hippo kinases in skeletal and heart muscle physiology could have important implications for translational research.
Question: Which are the coactivators of the Yes-associated protein (yap)? | [
"tead (tea domain) transcription factors."
] | task469-a4784effc7f4471c9ba0cb99f9ca2d10 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: Weathering changes solid rock into sediments. Sediments are different sizes of rock particles. Boulders are sedi- ments; so is gravel. At the other end, silt and clay are also sediments. Weathering causes rocks at the Earths surface to change form. The new minerals that form are stable at the Earths surface. It takes a long time for a rock or mountain to weather. But a road can do so much more quickly. If you live in a part of the world that has cold winters, you may only have to wait one year to see a new road start to weather (Figure Mechanical weathering breaks rock into smaller pieces. These smaller pieces are just like the bigger rock; they are just smaller! The rock has broken without changing its composition. The smaller pieces have the same minerals in the same proportions. You could use the expression a chip off the old block to describe mechanical weathering! The main agents of mechanical weathering are water, ice, and wind. Rocks can break apart into smaller pieces in many ways. Ice wedging is common where water goes above and below its freezing point (Figure 9.2). This can happen in winter in the mid-latitudes or in colder climates in summer. Ice wedging is common in mountainous regions. This is how ice wedging works. When liquid water changes into solid ice, it increases in volume. You see this when you fill an ice cube tray with water and put it in the freezer. The ice cubes go to a higher level in the tray than the water. You also may have seen this if you put a can of soda into the freezer so that it cools down quickly. If you leave the can in the freezer too long, the liquid expands so much that it bends or pops the can. (For the record, water is very unusual. Most substances get smaller when they change from a liquid to a solid.) Abrasion is another type of mechanical weathering. With abrasion, one rock bumps against another rock. Gravity causes abrasion as a rock tumbles down a slope. Moving water causes abrasion it moves rocks so that they bump against one another (Figure 9.3). Strong winds cause abrasion by blasting sand against rock surfaces. Finally, the ice in glaciers cause abrasion. Pieces of rock embedded in ice at the bottom of a glacier scrape against the rock below. If you have ever collected beach glass or pebbles from a stream, you have witnessed the work of abrasion. Sometimes biological elements cause mechanical weathering. This can happen slowly. A plants roots grow into a crack in rock. As the roots grow larger, they wedge open the crack. Burrowing animals can also cause weathering. By digging for food or creating a hole to live in the animal may break apart rock. Today, human beings do a lot of mechanical weathering whenever we dig or blast into rock. This is common when we build homes, roads, and subways, or quarry stone for construction or other uses. Mechanical weathering increases the rate of chemical weathering. As rock breaks into smaller pieces, the surface area of the pieces increases. With more surfaces exposed, there are more places for chemical weathering to occur. Lets say you wanted to make some hot chocolate on a cold day. It would be hard to get a big chunk of chocolate to dissolve in your milk or hot water. Maybe you could make hot chocolate from some smaller pieces like chocolate chips, but it is much easier to add a powder to your milk. This is because the smaller the pieces are, the more surface area they have. Smaller pieces dissolve more easily. Chemical weathering is different than mechanical weathering. The minerals in the rock change. The rock changes composition and becomes a different type of rock. Most minerals form at high pressure or high temperatures deep within Earth. But at Earths surface, temperatures and pressures are much lower. Minerals that were stable deeper in the crust are not stable at the surface. Thats why chemical weathering happens. Minerals that formed at higher temperature and pressure change into minerals that are stable at the surface. Chemical weathering is important. It
Question: weathering process that occurs when water freezes in cracks in rocks | [
"ice wedging"
] | task469-1ded1990bdee4e3a93cb59b42260a14e | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: Haiti is the mountain range ''Hait'', and New York City becomes the ruins of ''Niourk''.
Question: Which place does Niourk exist in? | [
"new york city"
] | task469-2db45b29cd86473a896682d8e83e8ee2 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: Back at home, the Dallas Cowboys traveled to Nashville to face off against the Titans. The Titans started their rookie quarterback Vince Young after veteran Kerry Collins produced dismal results after the first 3 games of the season. The Titans were able to score with a field goal on their opening drive making it the first time this season that they were able to score in the first quarter. The Titans were held to two field goals in the first half while the Cowboys had a lead at halftime with two 13-yard TD passes from Drew Bledsoe to WR Terry Glenn to put them up 14-6. The Cowboys continued to drive up the score during the 3rd quarter with a 5-yard touchdown run by RB Julius Jones. During this play Titans' DT Albert Haynesworth stepped on the face of Cowboys center Andre Gurode. Haynesworth was flagged for Unsportsmanlike Conduct and ejected from the game. He protested his ejection by taking off his helmet and throwing it on the ground. He was then flagged again with another Unsportsmanlike Conduct penalty. Gurode left the field with an ice pack to his face and required stitched above his left eye. He did not return to the field. Head Coach Jeff Fisher as well as Haynesworth later apologized for his actions. Vince Young connected for his second touchdown of the year to TE Ben Troupe. During the 4th quarter, the Cowboys scored on a field goal by Mike Vanderjagt. LB Brady James intercepted Vince Young's pass intended for Ben Troupe and returned it for a touchdown. The Cowboys sealed the win with a 7-yard TD run by Tyson Thompson with a final score of 45 to 14. The Cowboys moved to 2 and 1 while the Titans continued to losing streak dropping to 0-4.
Question: Who caught the most touchdown passes in the first half? | [
"terry glenn"
] | task469-a1c03fe14d264aeeae676950528b393d | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: Mutations in FOXP2 cause developmental verbal dyspraxia (DVD), but only a few cases have been described. We characterize 13 patients with DVD--5 with hemizygous paternal deletions spanning the FOXP2 gene, 1 with a translocation interrupting FOXP2, and the remaining 7 with maternal uniparental disomy of chromosome 7 (UPD7), who were also given a diagnosis of Silver-Russell Syndrome (SRS). Of these individuals with DVD, all 12 for whom parental DNA was available showed absence of a paternal copy of FOXP2. Five other individuals with deletions of paternally inherited FOXP2 but with incomplete clinical information or phenotypes too complex to properly assess are also described. Four of the patients with DVD also meet criteria for autism spectrum disorder. Individuals with paternal UPD7 or with partial maternal UPD7 or deletion starting downstream of FOXP2 do not have DVD. Using quantitative real-time polymerase chain reaction, we show the maternally inherited FOXP2 to be comparatively underexpressed. Our results indicate that absence of paternal FOXP2 is the cause of DVD in patients with SRS with maternal UPD7. The data also point to a role for differential parent-of-origin expression of FOXP2 in human speech development.
Question: Which gene is responsible for proper speech development? | [
"foxp2"
] | task469-0f95ab5d1fad4453830c372cd3dc83c1 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: Paris, 1966...Monsieur Charles Bonnet (Hugh Griffin), the current head of the Bonnet family, custodian of the family's legendary collection of fine art, and a noted collector in his own right, is offering one of his prized paintings at auction. A Cezanne, it sells for a fabulous $515,000, the high point of the auction. When Bonnet's daughter, Nicole (Audrey Hepburn), hears the news on her car radio on her way home from work, she is shocked...and dismayed. The moment she arrives at their elegant old chateau, she runs upstairs calling her father. In his bedroom on the second floor, she opens the door to an antique wardrobe and steps inside, opens a false panel at the back of the wardrobe and climbs a hidden spiral staircase to her father's secret studio in the attic.Bonnet, it turns out, is a forger of fine art...cheerful and charming, but an unrepentant scoundrel. He is putting the finishing touches on his latest project, a flawless rendition of a famous lost Van Gogh. He has even found another painting from the same period, by an unknown artist, and has brushed dirt from the back of that canvas to transfer to his forgery. "I doubt if even Van Gogh himself would have gone to such pains with his work," he boasts. "He didn't have to, Papa," Nicole retorts, "he WAS Van Gogh!" She tells him in a tired voice (for what must surely be the thousandth time) that it's a crime to sell fake masterpieces. He replies that he only sells them to wealthy, private buyers, who get an undeniably fine painting in return.A noise in the driveway sends them both to the window: An armored car, a police van, a black limousine and half a dozen motorcycles have arrived and parked in front of the house. Nicole is terrified that the authorities have at last discovered Bonnet's hobby, but Bonnet explains that he has simply agreed to let the Claver-Lafayette Museum display their exquisite statuette of Venus, purportedly carved by 16th Century sculptor Benvenuto Cellini, in their latest exhibit. Nicole is not reassured: Their Cellini Venus is also a forgery...carved at the end of the 19th century by Bonnet's father, using Bonnet's mother as a model. Unlike paintings, she tells her father, it's an easy matter to detect forged sculptures. Bonnet brushes aside her concerns: since he's merely lending the statue, not selling it, there will be no reason to test its authenticity.He runs downstairs (followed closely by Nicole) to greet Monsieur Grammont (Ferdinand Gravey), the museum director, who is here with his assistants and an armed escort to transport the Venus. Bonnet shows him into the library, where the Venus stands in solitary splendor in its own special niche. Grammont is moved almost to tears by the sight of it...he congratulates Bonnet for keeping this fine piece in France, though he must have had many lucrative offers to buy it. Bonnet smiles modestly, and says, "Well, after all, one is still a Frenchman." The Venus is handed over, secured in a heavily padded case, Grammont thanks Bonnet effusively and leaves. Bonnet is jubilant, but Nicole is still worried. He waves off her concern, saying that her basic trouble is that she's honest...."but I don't tell you that to hurt your feelings," he adds kindly. "I get dizzy spells when we have these conversations, Papa," she complains. He invites her to attend the gala opening at the museum that night...she firmly declines.The Cellini Venus is the star of the exhibit, and Bonnet the most celebrated guest at the gala. Davis Leland (Eli Wallach), a wealthy American industrialist, is also present. He has recently taken up art collecting, and is pursuing it as obssessively as he pursued the acquisition of his millions. He is so taken with the Venus that he determines to find out all about Bonnet and his family...with the goal of somehow acquiring the Venus.The Bonnet chateau
Question: What does Nicole want Simon to steal? | [
"to use his burglary skills to steal the venus",
"the cellini venus statuette",
"the venus",
"the statue",
"venus"
] | task469-d582a0f516e34d618d5dec5f2847d0af | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: Coming off their bye week, the Saints stayed at home for their Week 8 fight with the visiting Baltimore Ravens. From the get-go, New Orleans trailed as quarterback Steve McNair got a 5-yard touchdown run for the only score of the quarter. In the second quarter, things only got worse for the Saints, as McNair completed a 4-yard touchdown pass to WR Clarence Moore, while rookie DB Ronnie Prude returned an interception 12 yards for a touchdown. New Orleans would get on the board, as quarterback Drew Brees completed a 32-yard touchdown pass to WR Joe Horn, yet Baltimore would increase their lead with McNair completing a 6-yard touchdown pass to TE Todd Heap. In the third quarter, the Ravens got another 12-yard touchdown interception return with rookie Strong Safety Dawan Landry making the pick for the only score of the period. In the fourth quarter, the Saints tried to mount a comeback, as Brees completed a 47-yard touchdown pass and a 25-yard touchdown pass to rookie WR Marques Colston. However, the Saints comeback drive would end there, as New Orleans fell to 5-2.
Question: Who scored the only points in the third quarter? | [
"dawan landry"
] | task469-bd23f6cf1df248a39f6c7076597a98d8 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: The Dolphins' eighth game was an AFC duel with the Ravens. The Dolphins trailed early after QB Joe Flacco completed a 32-yard TD pass to RB Willis McGahee. They replied with RB Ronnie Brown getting a 12-yard TD run. The Ravens got the lead back after kicker Billy Cundiff made a 26 and a 39-yard field goal. The Dolphins narrowed the lead with kicker Dan Carpenter nailing a 19-yard field goal. The Dolphins fell further behind after Flacco found WR Derrick Mason on a 12-yard TD pass. This was followed in the 4th quarter by Cundiff hitting a 20 and a 24-yard field goal.
Question: Who scored the longest touchdown? | [
"willis mcgahee"
] | task469-ba023d2816c14362908113c0efd3a078 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: In the 19th century, a Grande Dame (Jeanne Moreau) summons The Brothers Grimm to her palace, where the brothers discuss their interpretation of the Cinderella story and notice a painting displayed in the room. The Grande Dame shows the brothers a glass slipper and tells them the story of Danielle de Barbarac, the true story of Cinderella. In 16th-century France, widower Auguste de Barbarac (Jeroen Krabbe), father of eight-year-old Danielle, marries Rodmilla de Ghent (Anjelica Huston), a wealthy baroness with two young daughters, Marguerite and Jacqueline, but he dies of a heart attack shortly afterwards. Before dying, Auguste's last words are directed to Danielle, which causes the Baroness to envy Danielle and treat her miserably for the next ten years. While Marguerite (Megan Dodds) is hostile and cruel to Danielle, Jacqueline (Melanie Lynskey) is kinder and more respectful to her, though she often stays out of the crossfires to keep the peace. By the time Danielle (Drew Barrymore) is eighteen, the estate has fallen into decline, as the Baroness has no interest in farming and wishes to get back to court as soon as possible. Danielle has been reduced to a servant in her own home, waiting on her stepmother and stepsisters, and clinging to her father's last gift, a copy of Thomas More's Utopia. While collecting apples, Danielle sees a man stealing her father's horse and unseats him with an apple. When she recognizes he is Prince Henry (Dougray Scott), she abases herself. He gives her a bag of gold in exchange for her silence. She decides to use the money to rescue their servant, Maurice (Walter Sparrow), whom the Baroness has sold to pay her debts. Henry's escape from the duties of court is foiled when he encounters a band of gypsies robbing an old man. He learns that the old man is Leonardo da Vinci (Patrick Godfrey), who has been summoned to court. Henry chases a thief and returns the Mona Lisa to da Vinci, then returns with him. Meanwhile, Danielle dresses as a noblewoman and leaves to buy back Maurice, but the guards refuse, saying he is being deported to the Americas. She argues for his release and, when Henry overhears, he orders Maurice's release. Intrigued by Danielle's mysterious identity, and amazed by her eloquence and passionate pleas, he begs for her name. Danielle gives Henry the name of her mother, "Comtesse Nicole de Lancret", who died giving birth to Danielle. King Francis (Timothy West) and Queen Marie (Judy Parfitt) tell Henry that he must choose a bride before the upcoming masquerade ball, or he will have to wed the Spanish princess Gabriella. All the noble families receive an invitation and Danielle initially believes she is included. When collecting truffles, she meets Henry by the river in the company of da Vinci. Henry and Danielle engage in a lively debate before Danielle runs off after she notices Jacqueline searching for her. Henry invites her to visit the library of a nearby monastery. On the way home, they are ambushed by the gypsies, who are amused by Danielle's outrage and agree to release her with whatever she can carry. When she picks up Henry and begins to walk away, the gypsies offer them a horse. Henry and Danielle spend the night at the gypsy camp, sharing their first kiss and arranging to meet again. The next morning, Danielle catches the Baroness and Marguerite stealing her mother's dress and slippers for Marguerite to wear to the ball. After Marguerite insults Danielle about her mother's death, she punches Marguerite in the face and chases her around the manor until Marguerite threatens to throw Utopia into the fireplace. Danielle returns her mother's slippers to the Baroness in exchange for the book but Marguerite burns it in the fire anyway in an act of spite. After Danielle is punished by whipping, Jacqueline tends to her wounds and condemns Marguerite for insulting Danielle's deceased mother. When Danielle meets Henry later, she wishes to tell him the truth, but is afraid he will reject her after he confesses his love. During
Question: what is henry? | [
"he is prince"
] | task469-6f9361e962da4910988b2519704a1811 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: C.D. "Charlie" Bales, the fire chief of the small American ski town of Nelson, Washington, is intelligent, humorous, charismatic, athletic and skilled. Bales is sensitive about his large nose, which many in town have learned to not mention. He is unable to have it surgically altered because of a dangerous allergy to anesthetics. He is close to many in town, especially his godsister, Dixie, who owns the town diner and several rental homes. He becomes immediately attracted to beautiful newcomer Roxanne Kowalski, an astronomy student renting from Dixie while searching for a new comet. She adores Bales, but only as a friend, preferring Chris, a handsome but dim fireman. Roxanne goes to Bales for help when Chris fails to advance their relationship further than curious glances. Through a turn of events, she falsely believes Chris is deeply intelligent. When Bales informs Chris of Roxanne's interest, Chris gets sick, intimidated by intelligent women. Chris starts to write her a letter, but takes all day with little result. He convinces Bales to write the letter, with prose that soon bowls over Roxanne. When informed that Roxanne wants to meet him, Chris again gets sick and refuses to meet until Bales comes up with a plan to allow him to be as brilliant as his letter makes him appear. Chris arrives at Roxanne's house with a hunter's cap on, hiding the earphones that relay Bales' words. When the equipment fails, Chris bungles the meeting by speaking his own crass thoughts. After Roxanne storms back into the house furious, Chris begs Bales to fix his mess again. At first he repeats what he is told from under a tree beneath Roxanne's window, but soon also ruins that. Then they switch jackets and hats so Bales can speak the words as Chris. They achieve their goal, and she invites Chris in to make love. Roxanne gets word about the comet and has to go out of town for a week. Since she can't find Chris, she gives Bales the address of her hotel and asks him to tell Chris to write to her. Bales writes her several times a day, each letter more incredible than the last. They affect Roxanne so deeply that she returns early. Bales is writing a new letter to her in Dixie's diner when he finds out that Chris (who knows nothing about the letters) is on his way to see Roxanne. He arrives at her home and warns Chris that Roxanne would be mentioning some letters that he supposedly wrote. She tries to get Chris to be the man in the letters, revealing that his looks are only secondary to her. Knowing that his looks are all he has, Chris runs out, leaving her confused. Dixie puts the last letter under her door and after reading it, Roxanne calls Bales over. Chris prepares to leave town with a bartender, Sandy, whom he met while Roxanne was away. When she asks if he has told Roxanne (the women are acquaintances), he replies that he will write her a letter since he has a history of it. Bales arrives, unaware that Roxanne knows the truth. She asks him to read one of the letters and then to look at the back, which shows that Dixie revealed its true author. She explodes in anger that he lied to her. He retorts that he simply wanted to tell her how he felt about her, but she was only interested in Chris's face and body. When he reminds her that it only took a few nice words for Chris to get her into bed, she punches him in the face and throws him out. As he prepares to say more he stops and sniffs the air. He slowly walks back to the firehouse and alerts his team, who then "follow his nose" until they find and extinguish the fire. During their celebration afterwards, someone mentions his nose and although everyone thinks he will get upset, he doesn't. Back home, sitting on his roof, Bales hears someone speaking his words to him. It's Roxanne, declaring that she realizes that it was everything from Bales that she loved, not Chris'
Question: Whom does C.D. Bales love? | [
"roxanne kowalski",
"roxanne"
] | task469-f803d3f2274d4f94ab1c092275d28823 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: Evaluate efficacy and safety of tanezumab, a humanized monoclonal antibody against nerve growth factor, in neuropathic pain. Two randomized controlled trials. Patients with pain due to diabetic peripheral neuropathy (DPN) or postherpetic neuralgia (PHN). In the DPN study, patients received subcutaneous tanezumab 20 mg or placebo on Day 1 and Week 8. Evaluations included change from baseline in average DPN pain (primary endpoint), Patient's Global Assessment of DPN, and safety (including neuropathy assessments). Due to a partial clinical hold limiting enrollment and treatment duration, the prespecified landmark analysis was modified post hoc from Week 16 to Week 8. In the PHN study, patients received intravenous tanezumab 50 g/kg, tanezumab 200 g/kg, or placebo on Day 1. Evaluations included change from baseline in average daily pain (primary endpoint), Brief Pain Inventory-short form, Patient's Global Assessment of pain from PHN, and safety. Mean DPN pain reduction from baseline to Week 8 was greater with tanezumab vs placebo (P = 0.009); differences in Patient's Global Assessment of DPN were not significant (P > 0.05). Neither tanezumab dose resulted in significant differences vs placebo in efficacy in PHN (P > 0.05), although tanezumab 200 g/kg provided some benefit. Neuropathy assessments showed no meaningful changes. Tanezumab provided effective pain reduction in DPN. In PHN, only the highest tanezumab dose reduced pain; treatment differences were not significant. No new safety concerns were observed despite preexisting neuropathy.
Question: What is the target of tanezumab? | [
"ngf",
"nerve growth factor"
] | task469-48970aad8f5641d5ae4ac06b14de8334 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: Nestin is an intermediate filament protein expressed in neuroepithelial stem cells during development and it is later replaced by cell specific neuronal or glial filaments. Nevertheless, nestin cells remain within adult tissues and they can be regarded as potential neural stem cell (NSC). Nestin cells have been detected in Schwann cells related with sensory corpuscles of rodent and they have been demonstrated to be NSC. We have investigated the existence of nestin in human cutaneous cells Meissner and Pacinian corpuscles through the use of immunohistochemistry techniques and in situ hybridization. S100 protein (also regarded as a marker for NSC) and vimentin (the intermediate filament of mature Schwann cells in sensory corpuscles) were also investigated. The results show that the adult human cutaneous sensory Meissner and Pacinian corpuscles contains a small population of Schwann-related cells (vimentin) which on the basis of their basic immunohistochemical characteristics (S100 protein, nestin) can be potential NSCs. Cells sharing identical immunohistochemical profile were also found in the close vicinity of Meissner corpuscles. Because their localization they are easily accessible and may represent a peripheral niche of NSC to be used for therapeutic goals.
Question: Which intermediate filament (IF) protein can be used as a non-specific marker of the neuronal precursor cells of the subventricular zone? | [
"nestin"
] | task469-e793ad491a434e26920304c843219f68 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: Francesco Maria Schiaffino (1688 -- January 3, 1763) was an Italian sculptor of the Rococo or late-Baroque, mainly active in his native city of Genoa.
Question: What city did Francesco Maria Schiaffino live when he died? | [
"genoa"
] | task469-8d7a216f502642a988207f0791cc80a3 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: Siltuximab is a chimeric, anti-interleukin-6 monoclonal antibody with potential therapeutic benefit in castration-resistant prostate cancer (CRPC) patients. We assessed the safety and tolerability of siltuximab in combination with docetaxel, the pharmacokinetics of docetaxel alone and with siltuximab, and the efficacy and pharmacodynamics of siltuximab plus docetaxel. In an open-label, dose-escalation, multicenter, phase 1 study, patients with metastatic, progressive CRPC received docetaxel 75 mg/m(2) q3w plus siltuximab 6 mg/kg q2w (n=12), 9 mg/kg q3w (n=12), or 12 mg/kg q3w (n=15). Dose-limiting toxicity (DLT), PSA, and radiologic response according to WHO criteria were evaluated. DLT was reported in 1 of 11 patients receiving 6 mg/kg, 1 of 12 receiving 9 mg/kg, and in 1 of 14 receiving 12 mg/kg. Common Grade 3 adverse events were neutropenia (73 %), leukopenia (60 %), lymphopenia (30 %), dyspnea (19 %), and fatigue (14 %). Toxicities were not dose dependent. Siltuximab did not affect docetaxel pharmacokinetics. The pharmacokinetic profile for siltuximab in combination was similar to single-agent siltuximab pharmacokinetics. Twenty-three (62 %; 95 % CI 45 %, 78 %) of 37 combination-treated patients achieved a confirmed 50 % PSA decline. Of 17 patients with measurable disease at baseline, 2 confirmed and 2 unconfirmed radiologic partial responses ranging 190 to 193 days were achieved with 9- and 12-mg/kg siltuximab. C-reactive protein concentrations were suppressed throughout treatment in all patients. These results suggest that siltuximab in combination with docetaxel is safe and shows preliminary efficacy in patients with CRPC, although alternative siltuximab schedules may be better tolerated for future studies.
Question: Which interleukin is blocked by Siltuximab? | [
"interleukin-6"
] | task469-ad0165651ed140fca998f63803cd7098 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: According to 2011 census of India, Kumbakonam had a population of 140,156 with a sex-ratio of 1,021 females for every 1,000 males, much above the national average of 929. A total of 12,791 were under the age of six, constituting 6,495 males and 6,296 females.The average literacy of the city was 83.21%, compared to the national average of 72.99%. There were a total of 9,519 workers, comprising 32 cultivators, 83 main agricultural labourers, 1,206 in house hold industries, 7,169 other workers, 1,029 marginal workers, 24 marginal cultivators, 45 marginal agricultural labourers, 212 marginal workers in household industries and 0 other marginal workers.
Question: Which gender under the age of six populated more of Kumbakonam, males or females? | [
"males"
] | task469-7c4c5f0978c14ea482b63de763ad03b0 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: One Saturday morning Ann was going on business. Before starting, she took her son Sam to her friends, Bill and Kate, and asked them to look after him for the day. Sam, an independent boy of six years old, had black hair and was wearing a pair of jeans and a bright yellow shirt. At eleven o'clock Bill took Sam into town. Sam walked along behind Bill, looking at the windows of all the shops they passed. After lunch they went to the park and walked about. The whole place was very crowded. Bill stopped to buy some chocolate. When he turned round to give some to Sam, the boy wasn't there. Bill ran round calling Sam, but he couldn't find him. About an hour later, just in front of a shop, he saw the black hair, the pair of jeans and the bright yellow shirt. The boy looked as if he was waiting for someone to come out of the shop. Bill ran across the road, took the boy by the hand and hurried off, as it was quite late. The boy began to cry and pull hard, but Bill, who didn't know much about children, couldn't understand a word the boy was saying. All the boy made was a lot of noise. When they got home at last, Bill went straight to the kitchen, with the boy still crying. At the door Bill stopped with an amazed look. There, sitting at the kitchen table with Kate, was a small boy with black hair, in a pair of jeans and a bright yellow shirt.
Question: What did Bill buy for Sam? | [
"chocolate."
] | task469-fa17a53fac404fc89d951e5aa97cda16 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: Applying to Stellinga College Why Stellinga? Thank you for your interest in Stellinga International College. As an international student, we are sure you will find our college an exciting place to study, with like-minded and ambitious people. Preparing and submitting your application We have tried to make the application process as easy as possible for you, but there are a number of procedures you must follow. All our courses are taught in English, so first of all you will probably need to submit evidence of your English language ability. We require an IELTS score of 6.5. You will also have to send us your secondary school diploma, so that we can evaluated it. We will also require a personal statement. This is a text of up to 1,000 words in which you introduce yourself, explain your interest in our college, and why you want to study your chosen course. If you are from outside the European Union(EU), it is important that you have an entrance visa before you come to study in the Netherlands, but we will apply for this for you. We now only accept online applications, so please ensure that you have all your documents ready to upload before you begin. Any documents that are not in English originally will also need to be translated and the translation also uploaded. You will need a passport photograph; a copy of your passport; copies of all your certificates and diplomas; your proof of language ability; and your personal statement in English. What happens next? Your application will then be considered. If your initial application is successful, you will be invited for an interview. This will be conducted in English via skype, over the phone or on site. You will talk to two or three members of staff for up to 30 minutes. We aim to inform you of our decision in writing, within 4 weeks. There are several possible outcomes: you may not have been successful; you may be offered a place on the waiting list. You will need to reply to any offers within two weeks, otherwise your place may be offered to somebody else. Good luck with your application.
Question: Which is unnecessary for people inside the EU when submitting applications? | [
"an entrance visa."
] | task469-3fb7b0a38b374b44a6ad780bf9b5f1ec | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: Gas station attendant Clint Ramsey, who works at Martin Bormann's Super Service in the desert, finds himself too irresistible to a series of girls, all of whom have the word "Super" in their given names. In the beginning, he is married to the hypersexual, demanding, and jealous SuperAngel (Shari Eubank), who constantly harasses him at work. She orders him home at once when she calls Clint and overhears a female customer, SuperLorna (Christy Hartburg), hitting on him at work. Clint finds SuperAngel's constant accusations and arguing a turnoff and, back at home, they fight after he rejects her aggressive advances. A neighbor calls the police as Clint leaves for a local bar, where the bartender is the very scantily clad SuperHaji (Haji). Meanwhile, SuperAngel seduces Harry Sledge (Charles Napier), the cop who responded to the police call. He is impotent and unable to perform. She repeatedly taunts and insults him over this, which finally results in him killing her by stomping her brutally in a bathtub, then throwing a radio in the water which was plugged into the wall socket. Sledge burns down the house, then tries to pin the murder on Clint. Clint claims being in the pub all night, but SuperHaji has her revenge on him (from insulting her breast size earlier) by refusing to confirm his alibi. Clint is then forced to flee. In his rush to escape, Clint hitchhikes a ride from a boy (John LaZar) and his girlfriend SuperCherry (Colleen Brennan). During the drive, SuperCherry comes on to him and puts his hand over her breast, but then pulls it back. She then tries to give him a handjob over his pants, but he continues to resist her advances. The driver takes offense to Clint rejecting his girlfriend, but she says he probably just wants a closer contact. She again attempts and fails to seduce him and he asks the driver to let him get out. The driver follows him out and beats and robs him. Clint is found by an old farmer who takes him to his farm to heal from his injuries and Clint agrees to work for the farmer for a week to repay him. The farmer has a younger Austrian mail-order bride, SuperSoul (Uschi Digard), who is hypersexual. After energetically satisfying her husband, she comes knocking on Clint's door at night. She immediately pushes him into his bed where she proceeds to mount and rape him, until he manages to overpower her. However, she does the same the following day and this time overpowering him after jumping him from behind in the barn. Looking for SuperSoul, the farmer finds them in the barn, then chases Clint away and punches SuperSoul. Fleeing from the farm, Clint meets a motel owner and his deaf daughter, SuperEula (Deborah McGuire), who convinces him to take a ride with her in her dune buggy to have sex in the desert. They are caught by her father and chased out of town. Clint eventually meets up with SuperVixen (also played by Shari Eubank) at Supervixen's Oasis, a roadside diner. SuperVixen is (inexplicably) a friendly and giving reincarnation of SuperAngel, whose ghost now appears nude between scenes to comment on the plot from atop a bedspring balanced on a mesa. Clint and SuperVixen fall in love and are inseparable, although their common nemesis, Harry Sledge, arrives on the scene and plots ending the lives of the now happy couple.
Question: Who takes Clint in after he runs from being set up by Clint? | [
"the old farmer"
] | task469-c57c549abdfb4236bb0e30cff06e628a | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: Michael Jackson is one of the world's best singers. Michael Jackson was born in the middle west of the city of Gary, Indiana, in 1958. He began singing with his four brothers. They called the group "The Jackson Five". The group became very popular after appearing on a television program. They started singing in 1965, and became popular soon. In 1970 the group made their first record with the name of "I Want You Back". It was very popular. One of their hit records was "Never Say Goodbye". Michael was good at dancing as well as singing, such as his dance moves and moon walking. He was asked to act in a film in 1978 for the first time, and in the same year he made a record on his own, which sold eight million _ all over the world. Michael nearly didn't go out because he was too famous. Once his fans went off in a faint when they saw him at the concert. No one can do it by now. He lived in a large house and kept lots of animals. He never ate meat. He often raised money for Charity. This made him win the Guinness World Records in 2006. He died on June 25th, 2009, but he would live in our heart forever.
Question: What's the name of their first record? | [
"\"i want you back\""
] | task469-3d8de3c44e4d463aabc72a0b6a785a37 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: An infectious disease is a disease that is caused by a pathogen. A pathogen is an organism or virus that causes disease in another living thing. Pathogens are commonly called germs. Watch this dramatic video for an historic perspective on infectious diseases and their causes: . MEDIA Click image to the left or use the URL below. URL: There are several types of pathogens that cause diseases in human beings. They include bacteria, viruses, fungi, and protozoa. The different types are described in Table 21.1. The table also lists several diseases caused by each type of pathogen. Many infectious diseases caused by these pathogens can be cured with medicines. For example, antibiotic drugs can cure most diseases caused by bacteria. Different pathogens spread in different ways. Some are easy to catch. Others are much less contagious. Some pathogens spread through food or water. When harmful bacteria contaminate food, they cause foodborne illness, commonly called food poisoning. An example of a pathogen that spreads through water is the protozoan named Giardia lamblia, described in Table 21.1. It causes a disease called giardiasis. Some pathogens spread through sexual contact. In the U.S., the pathogen most commonly spread this way is HPV, or human papillomavirus. It may cause genital warts and certain types of cancer. A vaccine can prevent the spread of this pathogen. Many pathogens spread by droplets in the air. Droplets are released when a person coughs or sneezes, as you can see in Figure 21.2. The droplets may be loaded with pathogens. Other people may get sick if they breathe in the pathogens on the droplets. Viruses that cause colds and flu can spread this way. Other pathogens spread when they are deposited on objects or surfaces. The fungus that causes athletes food spreads this way. For example, you might pick up the fungus from the floor of a public shower. You can also pick up viruses for colds and flu from doorknobs and other commonly touched surfaces. Still other pathogens are spread by vectors. A vector is an organism that carries pathogens from one person or animal to another. Most vectors are insects such as ticks or mosquitoes. They pick up pathogens when they bite an infected animal and then transmit the pathogens to the next animal they bite. Ticks spread the bacteria that cause Lyme disease. Mosquitoes spread the protozoa that cause malaria. What can you do to avoid infectious diseases? Eating well and getting plenty of sleep are a good start. These habits will help keep your immune system healthy. With a healthy immune system, you will be able to fight off many pathogens. Vaccines are available for some infectious diseases. For example, there are vaccines to prevent measles, mumps, whooping cough, and chicken pox. These vaccines are recommended for infants and young children. You can also take the following steps to avoid picking up pathogens or spreading them to others. Watch this video for additional information on preventing the spread of infectious diseases: MEDIA Click image to the left or use the URL below. URL: Wash your hands often with soap and water. Spend at least 20 seconds scrubbing with soap. See Figure 21.3 for effective hand washing tips. Avoid touching your eyes, nose, or mouth with unwashed hands. Avoid close contact with people who are sick. This includes kissing, hugging, shaking hands, and sharing cups or eating utensils. Cover your coughs and sneezes with a tissue or shirt sleeve, not your hands. Disinfect frequently touched surfaces, such as keyboards and doorknobs, especially if someone is sick. Stay home when you are sick. The best way to prevent diseases spread by vectors is to avoid contact with the vectors. For example, you can wear long sleeves and long pants to avoid tick and mosquito bites. Using insect repellent can also reduce your risk of insect bites.
Question: __any disease that is caused by pathogens | [
"infectious disease"
] | task469-7adcb109ba234c3385afda12ba85b228 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: The similarities of the larval and nymph stages of the tick and louse (Pthirus pubis) may lead to misdiagnosis in rare cases of infestation of the eyelashes. The most frequent manifestations of tick in the eye are conjunctivitis, uveitis, keratitis, and vasculitis. Tick inoculation of the skin can locally lead to formation of granuloma and abscess. More concerning is the potential systemic sequelae that can result from transmission of zoonoses such as Lyme disease. P. pubis can cause pruritic eyelid margins or unusual blepharoconjunctivitis. We present a case of phthiriasis palpebrarum in a 4-year-old boy.
Question: What is the cause of Phthiriasis Palpebrarum? | [
"pthirus pubis"
] | task469-9867e37ab7b846d59e03f1aa3ccda2d1 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: at the Georgia Dome, Atlanta, Georgia Trying to end a three-game skid, the Falcons returned home for an NFC South rematch with the New Orleans Saints. From the get-go, the Falcons trailed as in the first quarter, QB Drew Brees completed a 76-yard TD pass to WR Devery Henderson, while RB Deuce McAllister got a 1-yard TD run. Atlanta would respond with kicker Morten Andersen kicking a 22-yard field goal. In the second quarter, Andersen gave the Falcons a 30-yard field goal, yet New Orleans continued dominating with Brees completing an incredible 48-yard TD pass to WR Terrance Copper on the very last offensive play of the half. In the third quarter, RB Warrick Dunn gave Atlanta some room to operate, as he a 1-yard TD run for the only score of the half. However, in the fourth quarter, the Saints wrapped up the game with kicker John Carney getting a 25-yard field goal, while McAllister got a 9-yard TD run. After the game, as QB Michael Vick was leaving the field, he flicked off an insulting fan with both hands. He was fined $10,000 from the NFL and had to donate another $10,000 to charity. With their fourth-straight loss, the Falcons fell to 5-6.
Question: Which team got on the board first? | [
"saints"
] | task469-de6fb194e29b4ff980b6eb05778e4eff | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: Coming off their come-from-behind win over the Dolphins, the Broncos traveled to Arrowhead Stadium for an AFC West rematch with the Kansas City Chiefs. The Broncos jumped out to a 14-0 lead on their first two possessions in the first quarter, with quarterback Peyton Manning throwing a pair of touchdown passes a 23-yarder to wide receiver Demaryius Thomas and a 15-yarder to running back C. J. Anderson. A 22-yard field goal by placekicker Connor Barth increased the Broncos' lead to 17-0 early in the second quarter. The scoring play occurred after the Broncos' special teams fooled the Chiefs with a fake punt run by safety David Bruton and a fourth-down conversion by Anderson. The Chiefs got on the scoreboard later in the second quarter, with quarterback Alex Smith connecting on a 20-yard touchdown pass to tight end Anthony Fasano. The Broncos' offense subsequently marched down the field, but had to settle on a 24-yard field goal by Barth just before halftime. The Chiefs' defense forced a fumble off Manning deep in Broncos' territory on the Broncos' first possession of the second half, but had to settle on a 39-yard field goal by placekicker Cairo Santos. Barth added two more field goals a 30-yarder midway through the third quarter and a 33-yarder early in the fourth quarter to increase the Broncos' lead to 26-10. The first field goal came after a DeMarcus Ware interception of Smith on a deflected pass, while the second field goal came after Chiefs' cornerback Marcus Cooper muffed a punt. The Chiefs narrowed the Broncos' lead, with Smith throwing a 12-yard touchdown pass to running back Jamaal Charles. However, Broncos' safety T. J. Ward knocked away a two-point conversion pass from Smith intended for Fasano that would have brought the Chiefs to within a one-score deficit. Barth added one more field goal a 37-yarder midway through the fourth quarter. The Broncos' defense subdued the Chiefs for the remainder of the game. With the win, the Broncos swept the Chiefs for a third consecutive season. Peyton Manning improved his personal record to 11-1 all-time in games against the Chiefs.
Question: What quarter did Barth add the 37 yard field goal? | [
"the fourth quarter"
] | task469-6151112676d4450da6099bbf7c4a0ba0 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: Rudolf Teschner (16 February 1922, Potsdam -- 23 July 2006, Berlin-Steglitz) was a German chess master and writer.
Question: What nationality of Rudolf Teschner? | [
"german"
] | task469-34ee9d6255aa4d678f568986b0b69bba | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: Earth formed at the same time as the other planets. The history of Earth is part of the history of the Solar System. Earth came together (accreted) from the cloud of dust and gas known as the solar nebula nearly 4.6 billion years ago, the same time the Sun and the rest of the solar system formed. Gravity caused small bodies of rock and metal orbiting the proto-Sun to smash together to create larger bodies. Over time, the planetoids got larger and larger until they became planets. When Earth first came together it was really hot, hot enough to melt the metal elements that it contained. Earth was so hot for three reasons: Gravitational contraction: As small bodies of rock and metal accreted, the planet grew larger and more massive. Gravity within such an enormous body squeezes the material in its interior so hard that the pressure swells. As Earths internal pressure grew, its temperature also rose. Radioactive decay: Radioactive decay releases heat, and early in the planets history there were many ra- dioactive elements with short half lives. These elements long ago decayed into stable materials, but they were responsible for the release of enormous amounts of heat in the beginning. Bombardment: Ancient impact craters found on the Moon and inner planets indicate that asteroid impacts were common in the early solar system. Earth was struck so much in its first 500 million years that the heat was intense. Very few large objects have struck the planet in the past many hundreds of millions of year. When Earth was entirely molten, gravity drew denser elements to the center and lighter elements rose to the surface. The separation of Earth into layers based on density is known as differentiation. The densest material moved to the center to create the planets dense metallic core. Materials that are intermediate in density became part of the mantle (Figure 1.1). Lighter materials accumulated at the surface of the mantle to become the earliest crust. The first crust was probably basaltic, like the oceanic crust is today. Intense heat from the early core drove rapid and vigorous mantle convection so that crust quickly recycled into the mantle. The recycling of basaltic crust was so effective that no remnants of it are found today. There is not much material to let us know about the earliest days of our planet Earth. What there is comes from three sources: (1) zircon crystals, the oldest materials found on Earth, which show that the age of the earliest crust formed at least 4.4 billion years ago; (2) meteorites that date from the beginning of the solar system, to nearly 4.6 billion years ago (Figure 1.2); and (3) lunar rocks, which represent the early days of the Earth-Moon system as far back as 4.5 billion years ago.
Question: which is not a reason why earth was molten in its early days? | [
"the sun"
] | task469-4eb4d5f60aa74228bd3a5e0a02d050ff | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: Somharuthai Jaroensiri is a retired female badminton player from Thailand.
Question: What is Somharuthai Jaroensiri's gender? | [
"female"
] | task469-ccbfa2e2e89648dfb8e08752af06af7d | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: Bob and Doug McKenzie (Rick Moranis and Dave Thomas) are two dim-witted and unemployed "hosers" living in Toronto, Ontario who find themselves in a bind when they squander their father's beer money and then run out of beer. The brothers place a live mouse in a beer bottle in an attempt to blackmail the local beer store into giving them free Elsinore beer, but are told to take up the matter at the Elsinore brewery instead. After presenting the mouse to management at the brewery, the brothers are given jobs on the bottling line inspecting the bottles for mice. They take this opportunity to drink lots of free beer off the line; later, they present their parents with a van full of free Elsinore beer products as part of their payment with their new jobs.Meanwhile, the evil owner of the brewery, Brewmeister "B.M." Smith (Max von Sydow), is perfecting a secret plan to take over the world by placing a mind-control drug in Elsinore beer which, while rendering the consumer docile, also makes him or her attack others when stimulated by certain musical tones. Smith tests this adulterated beer on patients of the conveniently located Royal Canadian Institute for the Mentally Insane, which is connected by underground tunnels to the brewery. The effects of the tainted beer are demonstrated in an extended sequence during which the mental patients don armored Star Wars-style hockey garb and, after consuming the beer, respond to synthesizer music by variously playing hockey, skating together in sync, and brawling on the ice.It seems the former brewery owner John Elsinore has recently died under mysterious circumstances and his daughter, Pam (Lynne Griffin), having recently turned 21, has been given full control of the Elsinore brewery. Pam's incompetent uncle Claude (Paul Dooley), in the interim, had married her widowed mother and is reluctant to give up his recently-gained control of the brewery. The reason for this is further revealed to be that the bumbling Claude is collaborating with Brewmeister Smith, for whom he is a buffoonish toady, providing a cover for the Brewmeister's nefarious plans. Bob and Doug blunder into the midst of these plans when they rescue Pam from a malfunctioning security gate and both become fast friends with her.While exploring the massive brewery, Bob and Doug find a shuttered cafeteria containing an old Galactic Border Patrol video game that supernaturally reveals that Brewmeister Smith murdered John Elsinore and that Uncle Claude was deeply involved. Additionally, while poking around the brewery, Bob and Doug meet a one time hockey great, Jean "Rosie" LeRose (Angus MacInnes), whom Bob recognizes from the hockey card he has back home at his parents' house. Having suffered a career-ending nervous breakdown and fallen under Smith's control, Rosie gets locked up at the insane asylum but is determined to fight against the Brewmeister's plot for world domination.Eventually, Bob and Doug wander into Brewmeister's operations room while he is away, and Doug takes a record disk of John Elsinore's murder, believing that it is a New Wave bootleg record. Immediately afterward, Brewmeister and Claude shoot the brothers with tranquilizers. They then dress up in the brothers clothes where they are shown on security camera shooting tranquilizer darts at Pam and a friendly associate, named Henry Green, and put their unconcious bodies in kegs.When Bob and Doug wake up, they are back in their van, convinced that their suspicious discoveries were all just dreams, and they are instructed by Claude to deliver two kegs of beer (actually containing an unconscious Pam and her father's friend, Henry Green) to a party at the bottom of a big hill. However, the brakes have been modified to only allow two stops before giving out altogether.Nevertheless, as Bob and Doug drive, they soon get distracted and decide to stop off at their house to feed their dog. They also leave behind the incriminating record disk of Brewmeister and Claude's actions at their house. Having wasted one stop prior, they find themselves unable to stop the now-speeding vehicle and eventually wind up jumping off of the Toronto pier into Lake Ontario. Rosie arrives and tries to rescue Pam who
Question: Who killed John? | [
"brewmeister smith"
] | task469-8f462ede5e6945d4bd8fd1cdb4ffbcd0 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: PITTSBURGH - For most people, snakes seem unpleasant or even threatening. But Howie Choset sees in their delicate movements a way to save lives. The 37-year-old Carnegie Mellon University professor has spent years developing snake-like robots he hopes will eventually slide through fallen buildings in search of victims trapped after natural disasters or other emergencies. Dan Kara is president of Robotics Trends, a Northboro, Mass.-based company that publishes an online industry magazine and runs robotics trade shows. He said there are other snake-like robots being developed, mainly at universities, but didn't know of one that could climb pipes. The Carnegie Mellon machines are designed to carry cameras and electronic sensors and can be controlled with a joystick . They move smoothly with the help of small electric motors, or servos, commonly used by hobbyists in model airplanes. Built from lightweight materials, the robots are about the size of a human arm or smaller. They can sense which way is up, but are only as good as their human operators, Choset added. Sam Stover, a search term manager with the Federal Emergency Management Agency based in Indiana, said snake-type robots would offer greater mobility than equipment currently available, such as cameras attached to extendable roles. "It just allows us to do something we've not been able to do before," Stover said, "We needed them yesterday." He said snifter dogs are still the best search tool for rescue workers, but that they can only be used effectively when workers have access to damaged building. Stover, among the rescue workers who handled the aftermath of Hurricane Katrina, said snake robots would have helped rescuers search flooded houses in that disaster. Choset said the robots may not be ready for use for another five to ten years, depending on funding.
Question: Which institution is responsible for the development of Choset's robots? | [
"carnegie mellon university."
] | task469-153d478032c2480eae6e636d67957778 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: Harvey Marlatt (born August 26, 1948) was a professional basketball player for the Detroit Pistons from 1970-1972.
Question: Player Harvey Marlatt played for which team? | [
"detroit pistons"
] | task469-5c532ebd7c5f43b78ee9de821b3981a1 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: To evaluate the long-term impact of successive interventions on rates of methicillin-resistant Staphylococcus aureus (MRSA) colonization or infection and MRSA bacteremia in an endemic hospital-wide situation. Quasi-experimental, interrupted time-series analysis. The impact of the interventions was analyzed by use of segmented regression. Representative MRSA isolates were typed by use of pulsed-field gel electrophoresis. A 950-bed teaching hospital in Seville, Spain. All patients admitted to the hospital during the period from 1995 through 2008. Three successive interventions were studied: (1) contact precautions, with no active surveillance for MRSA; (2) targeted active surveillance for MRSA in patients and healthcare workers in specific wards, prioritized according to clinical epidemiology data; and (3) targeted active surveillance for MRSA in patients admitted from other medical centers. Neither the preintervention rate of MRSA colonization or infection (0.56 cases per 1,000 patient-days [95% confidence interval {CI}, 0.49-0.62 cases per 1,000 patient-days]) nor the slope for the rate of MRSA colonization or infection changed significantly after the first intervention. The rate decreased significantly to 0.28 cases per 1,000 patient-days (95% CI, 0.17-0.40 cases per 1,000 patient-days) after the second intervention and to 0.07 cases per 1,000 patient-days (95% CI, 0.06-0.08 cases per 1,000 patient-days) after the third intervention, and the rate remained at a similar level for 8 years. The MRSA bacteremia rate decreased by 80%, whereas the rate of bacteremia due to methicillin-susceptible S. aureus did not change. Eighty-three percent of the MRSA isolates identified were clonally related. All MRSA isolates obtained from healthcare workers were clonally related to those recovered from patients who were in their care. Our data indicate that long-term control of endemic MRSA is feasible in tertiary care centers. The use of targeted active surveillance for MRSA in patients and healthcare workers in specific wards (identified by means of analysis of clinical epidemiology data) and the use of decolonization were key to the success of the program.
Question: What is MRSA? | [
"mrsa",
"methicillin-resistant s. aureus"
] | task469-fdb4a027a432435bb6038fe98b09af15 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: When a new moon passes directly between the Earth and the Sun, it causes a solar eclipse (Figure 24.20). The Moon casts a shadow on the Earth and blocks our view of the Sun. This happens only all three are lined up and in the same plane. This plane is called the ecliptic. The ecliptic is the plane of Earths orbit around the Sun. The Moons shadow has two distinct parts. The umbra is the inner, cone-shaped part of the shadow. It is the part in which all of the light has been blocked. The penumbra is the outer part of Moons shadow. It is where the light is only partially blocked. When the Moons shadow completely blocks the Sun, it is a total solar eclipse (Figure 24.21). If only part of the Sun is out of view, it is a partial solar eclipse. Solar eclipses are rare events. They usually only last a few minutes. That is because the Moons shadow only covers a very small area on Earth and Earth is turning very rapidly. Solar eclipses are amazing to experience. It appears like night only strange. Birds may sing as they do at dusk. Stars become visible in the sky and it gets colder outside. Unlike at night, the Sun is out. So during a solar eclipse, its easy to see the Suns corona and solar prominences. This NASA page will inform you on when solar eclipses are expected: [Link] Sometimes a full moon moves through Earths shadow. This is a lunar eclipse (Figure 24.22). During a total lunar eclipse, the Moon travels completely in Earths umbra. During a partial lunar eclipse, only a portion of the Moon enters Earths umbra. When the Moon passes through Earths penumbra, it is a penumbral eclipse. Since Earths shadow is large, a lunar eclipse lasts for hours. Anyone with a view of the Moon can see a lunar eclipse. Partial lunar eclipses occur at least twice a year, but total lunar eclipses are less common. The Moon glows with a dull red coloring during a total lunar eclipse. The Moon does not produce any light of its own. It only reflects light from the Sun. As the Moon moves around the Earth, we see different parts of the Moon lit up by the Sun. This causes the phases of the Moon. As the Moon revolves around Earth, it changes from fully lit to completely dark and back again. A full moon occurs when the whole side facing Earth is lit. This happens when Earth is between the Moon and the Sun. About one week later, the Moon enters the quarter-moon phase. Only half of the Moons lit surface is visible from Earth, so it appears as a half circle. When the Moon moves between Earth and the Sun, the side facing Earth is completely dark. This is called the new moon phase. Sometimes you can just barely make out the outline of the new moon in the sky. This is because some sunlight reflects off the Earth and hits the Moon. Before and after the quarter-moon phases are the gibbous and crescent phases. During the crescent moon phase, the Moon is less than half lit. It is seen as only a sliver or crescent shape. During the gibbous moon phase, the Moon is more than half lit. It is not full. The Moon undergoes a complete cycle of phases about every 29.5 days.
Question: inner part of the moons shadow during an eclipse | [
"umbra"
] | task469-aa045bda5d3b44c28f1ea57689214e89 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: Coming off their win over the Browns, the Bears stayed at home for a Week 9 duel with the Arizona Cardinals. Chicago would trail early in the first quarter as Cardinals quarterback Kurt Warner hooked up with wide receiver Larry Fitzgerald on an 11-yard touchdown pass. The Bears would answer as quarterback Jay Cutler competed a 33-yard touchdown pass to tight end Greg Olsen, but Arizona came right back as Warner hooked up with tight end Ben Patrick on a 6-yard touchdown pass. Chicago would find themselves in a huge deficit in the second quarter as Warner completed a 17-yard touchdown pass to Fitzpatrick and a 15-yard touchdown pass to tight end Anthony Becht, followed by kicker Neil Rackers nailing a 43-yard field goal. The Cardinals would add onto their lead as Rackers booted a 30-yard field goal in the third quarter. The Bears tried to rally in the fourth quarter as Cutler connected with Olsen on a 3-yard and a 20-yard touchdown pass, but Arizona pulled away with Warner completing a 4-yard touchdown pass to wide receiver Steve Breaston.
Question: Who threw the longest touchdown pass of the game? | [
"jay cutler"
] | task469-84bf03a4697c4d8cacf84b4cf5f28ee2 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: A solenoid is a coil of wire with electric current flowing through it, giving it a magnetic field (see Figure 25.5). Recall that current flowing through a straight wire produces a weak electromagnetic field that circles around the wire. Current flowing through a coil of wire, in contrast, produces a magnetic field that has north and south poles like a bar magnet. The magnetic field around a coiled wire is also stronger than the magnetic field around a straight wire because each turn of the wire has its own magnetic field. Adding more turns increases the strength of the field, as does increasing the amount of current flowing through the coil. You can see an actual solenoid with a compass showing its magnetic north pole at this URL: . Solenoids are the basis of electromagnets. An electromagnet is a solenoid wrapped around a bar of iron or other ferromagnetic material (see Figure 25.6). The electromagnetic field of the solenoid magnetizes the iron bar by aligning its magnetic domains. The combined magnetic force of the magnetized iron bar and the wire coil makes an electromagnet very strong. In fact, electromagnets are the strongest magnets made. Some of them are strong enough to lift a train. The maglev train described earlier, in the lesson "Electricity and Magnetism," contains permanent magnets. Strong electromagnets in the track repel the train magnets, causing the train to levitate above the track. Like a solenoid, an electromagnet is stronger if there are more turns in the coil or more current is flowing through it. A bigger bar or one made of material that is easier to magnetize also increases an electromagnets strength. You can see how to make a simple electromagnet at this URL: (4:57). MEDIA Click image to the left or use the URL below. URL: Many common electric devices contain electromagnets. Some examples include hair dryers, fans, CD players, telephones, and doorbells. Most electric devices that have moving parts contain electric motors. You can read below how doorbells and electric motors use electromagnets. Figure 25.7 shows a diagram of a simple doorbell. Like most doorbells, it has a button located by the front door. Pressing the button causes two electric contacts to come together and complete an electric circuit. In other words, the button is a switch. The circuit is also connected to a voltage source, an electromagnet, and the clapper of a bell. When current flows through the circuit, the electromagnet turns on, and its magnetic field attracts the clapper. This causes the clapper to hit the bell, making it ring. Because the clapper is part of the circuit, when it moves to strike the bell, it breaks the circuit. Without current flowing through the circuit, the electromagnet turns off. The clapper returns to its original position, which closes the circuit again and turns the electromagnet back on. The electromagnet again attracts the clapper, which hits the bell once more. This sequence of events keeps repeating as long as the button by the front door is being pressed. An electric motor is a device that uses an electromagnet to change electrical energy to kinetic energy. Figure 25.8 shows a simple diagram of an electric motor. The motor contains an electromagnet that is connected to a shaft. When current flows through the motor, the electromagnet turns, causing the shaft to turn as well. The rotating shaft moves other parts of the device. Why does the motors electromagnet turn? Notice that the electromagnet is located between the north and south poles of two permanent magnets. When current flows through the electromagnet, it becomes magnetized, and its poles are repelled by the like poles of the permanent magnets. This causes the electromagnet to turn toward the unlike poles of the permanent magnets. A device called a commutator then changes the direction of the current so the poles of the electromagnet are reversed. The reversed poles are once again repelled by the like poles of the permanent magnets. This causes the electromagnet to continue to turn. These events keep repeating, so the electromagnet rotates continuously. You can make a very simple electric motor with a battery, wire, and magnet following instructions at this URL: .
Question: coil of wire with electric current flowing through it, giving it a magnetic field | [
"solenoid"
] | task469-241fe727769c4008b6882fb875c3f332 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: Cellular respiration is the process of extracting energy in the form of ATP from the glucose in the food you eat. How does cellular respiration happen inside of the cell? Cellular respiration is a three step process. Briefly: 1. In stage one, glucose is broken down in the cytoplasm of the cell in a process called glycolysis. 2. In stage two, the pyruvate molecules are transported into the mitochondria. The mitochondria are the organelles known as the energy "powerhouses" of the cells (Figure 1.1). In the mitochondria, the pyruvate, which have been converted into a 2-carbon molecule, enter the Krebs cycle. Notice that mitochondria have an inner membrane with many folds, called cristae. These cristae greatly increase the membrane surface area where many of the cellular respiration reactions take place. 3. In stage three, the energy in the energy carriers enters an electron transport chain. During this step, this energy is used to produce ATP. Oxygen is needed to help the process of turning glucose into ATP. The initial step releases just two molecules of ATP for each glucose. The later steps release much more ATP. Most of the reactions of cellular respira- tion are carried out in the mitochondria. What goes into the cell? Oxygen and glucose are both reactants of cellular respiration. Oxygen enters the body when an organism breathes. Glucose enters the body when an organism eats. What does the cell produce? The products of cellular respiration are carbon dioxide and water. Carbon dioxide is transported from your mitochondria out of your cell, to your red blood cells, and back to your lungs to be exhaled. ATP is generated in the process. When one molecule of glucose is broken down, it can be converted to a net total of 36 or 38 molecules of ATP. This only occurs in the presence of oxygen. The overall chemical reaction for cellular respiration is one molecule of glucose (C6 H12 O6 ) and six molecules of oxygen (O2 ) yields six molecules of carbon dioxide (CO2 ) and six molecules of water (H2 O). Using chemical symbols the equation is represented as follows: C6 H12 O6 + 6O2 6CO2 + 6H2 O ATP is generated during the process. Though this equation may not seem that complicated, cellular respiration is a series of chemical reactions divided into three stages: glycolysis, the Krebs cycle, and the electron transport chain. Stage one of cellular respiration is glycolysis. Glycolysis is the splitting, or lysis of glucose. Glycolysis converts the 6-carbon glucose into two 3-carbon pyruvate molecules. This process occurs in the cytoplasm of the cell, and it occurs in the presence or absence of oxygen. During glycolysis a small amount of NADH is made as are four ATP. Two ATP are used during this process, leaving a net gain of two ATP from glycolysis. The NADH temporarily holds energy, which will be used in stage three. In the presence of oxygen, under aerobic conditions, pyruvate enters the mitochondria to proceed into the Krebs cycle. The second stage of cellular respiration is the transfer of the energy in pyruvate, which is the energy initially in glucose, into two energy carriers, NADH and FADH2 . A small amount of ATP is also made during this process. This process occurs in a continuous cycle, named after its discover, Hans Krebs. The Krebs cycle uses a 2-carbon molecule (acetyl-CoA) derived from pyruvate and produces carbon dioxide. Stage three of cellular respiration is the use of NADH and FADH2 to generate ATP. This occurs in two parts. First, the NADH and FADH2 enter an electron transport chain, where their energy is used to pump, by active transport, protons (H+ ) into the intermembrane space of mitochondria. This establishes a proton gradient across the inner membrane. These protons then flow down their concentration gradient, moving back into the matrix by facilitated diffusion. During this process, ATP is made by adding inorganic phosphate to ADP. Most of the ATP produced during cellular respiration is made during this stage. For each glucose that starts cellular respiration, in the presence of oxygen (aerobic conditions), 36-38 ATP are generated. Without oxygen, under
Question: how is atp made during the electron transport chain? | [
"by facilitated diffusion"
] | task469-c19125c5e64247928a797c2c2bf160b6 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: The major cause of outdoor air pollution is the burning of fossil fuels. Fossil fuels are burned in power plants, factories, motor vehicles, and home heating systems. Ranching and using chemicals such as fertilizers also cause outdoor air pollution. Erosion of soil in farm fields, mining activities, and construction sites adds dust particles to the air as well. Some specific outdoor air pollutants are described in Table 25.1. Air Pollutant Sulfur oxides Nitrogen oxides Carbon monoxide Carbon dioxide Particles (dust, smoke) Mercury Smog Ground-level ozone Source coal burning motor vehicle exhaust motor vehicle exhaust all fossil fuel burning wood and coal burning coal burning coal burning motor vehicle exhaust Problem acid rain acid rain poisoning global climate change respiratory problems nerve poisoning respiratory problems respiratory problems Outdoor air pollution causes serious human health problems. For example, pollutants in the air are major contributors to respiratory and cardiovascular diseases. Air pollution may trigger asthma attacks and heart attacks in people with underlying health problems. In fact, more people die each year from air pollution than automobile accidents. Air pollution may also cause acid rain. This is rain that is more acidic (has a lower pH) than normal rain. Acids form in the atmosphere when nitrogen and sulfur oxides mix with water in air. Nitrogen and sulfur oxides come mainly from motor vehicle exhaust and coal burning. If acid rain falls into lakes, it lowers the pH of the water and may kill aquatic organisms. If it falls on the ground, it may damage soil and soil organisms. If it falls on plants, it may make them sick or even kill them. Acid rain also damages stone buildings, bridges, and statues, like the one in Figure 25.1. Another major problem caused by air pollution is global climate change. Gases such as carbon dioxide from the burning of fossil fuels increase the greenhouse effect and raise Earths temperature. The greenhouse effect is a natural feature of Earths atmosphere. It occurs when certain gases in the atmosphere, including carbon dioxide, radiate the suns heat back down to Earths surface. Figure 25.2 shows how this happens. Without greenhouse gases in the atmosphere, the heat would escape into space. The natural greenhouse effect of Earths atmosphere keeps the planets temperature within a range that can support life. The rise in greenhouse gases due to human actions is too much of a good thing. It increases the greenhouse effect and causes Earths average temperature to rise. Rising global temperatures, in turn, are melting polar ice caps and glaciers. Figure 25.3 shows how much smaller the Arctic ice cap was in 2012 than it was in 1984. With more liquid water on Earths surface, sea levels are rising. Adding more heat energy to Earths atmosphere also causes more extreme weather and changes in precipitation patterns. Global warming is already causing food and water shortages and species extinctions. These problems will only grow worse unless steps are taken to curb greenhouse gases and global climate change. You may be able to avoid some of the health effects of outdoor air pollution by staying indoors on high-pollution days. However, some indoor air is just as polluted as outdoor air. One source of indoor air pollution is radon gas. Radon is a radioactive gas that may seep into buildings from rocks underground. Exposure to radon gas may cause lung cancer. Another potential poison in indoor air is carbon monoxide. It may be released by faulty or poorly vented furnaces or other fuel-burning appliances. Indoor furniture, carpets, and paints may release toxic compounds into the air as well. Other possible sources of indoor air pollution include dust, mold, and pet dander. Its easier to control the quality of indoor air than outdoor air. Steps home owners can take to improve indoor air quality include: keeping the home clean so it is as free as possible from dust, mold, and pet dander. choosing indoor furniture, flooring, and paints that are low in toxic compounds such as VOCs (volatile organic compounds). making sure that fuel-burning appliances are working correctly and venting properly. installing carbon monoxide alarms like the one in Figure 25.4 at every level of the home.
Question: Exposure to radon gas may cause cancer of the | [
"lung."
] | task469-20e0aa74f8c54a879b05e2556002f9ba | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: Satan's Circus is the fourth studio album by Death in Vegas, released on October 11, 2004 on Drone Records in the United Kingdom and on May 24, 2005 on Sanctuary Records in the United States.
Question: What is the name of the artist or group which originally performed Satan's Circus? | [
"death in vegas"
] | task469-aaf3b46c1ea6413ab00133130583f02c | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: Associacao Cultural e Desportiva Potyguar Seridoense play their home games at Estadio Municipal Coronel Jose Bezerra.
Question: What is the home venue of Associacao Cultural e Desportiva Potyguar Seridoense? | [
"estádio municipal coronel josé bezerra"
] | task469-12f981b79e254bc58993fbb977afaf54 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: DNA and RNA are nucleic acids. DNA stores genetic information. RNA helps build proteins. Proteins, in turn, determine the structure and function of all your cells. Proteins consist of chains of amino acids. A proteins structure and function depends on the sequence of its amino acids. Instructions for this sequence are encoded in DNA. In eukaryotic cells, chromosomes are contained within the nucleus. But proteins are made in the cytoplasm at structures called ribosomes. How do the instructions in DNA reach the ribosomes in the cytoplasm? RNA is needed for this task. RNA stands for ribonucleic acid. RNA is smaller than DNA. It can squeeze through pores in the membrane that encloses the nucleus. It copies instructions in DNA and carries them to a ribosome in the cytoplasm. Then it helps build the protein. RNA is not only smaller than DNA. It differs from DNA in other ways as well. It consists of one nucleotide chain rather than two chains as in DNA. It also contains the nitrogen base uracil (U) instead of thymine (T). In addition, it contains the sugar ribose instead of deoxyribose. You can see these differences in Figure 5.16. There are three different types of RNA. All three types are needed to make proteins. Messenger RNA (mRNA) copies genetic instructions from DNA in the nucleus. Then it carries the instructions to a ribosome in the cytoplasm. Ribosomal RNA (rRNA) helps form a ribosome. This is where the protein is made. Transfer RNA (tRNA) brings amino acids to the ribosome. The amino acids are then joined together to make the protein. How is the information for making proteins encoded in DNA? The answer is the genetic code. The genetic code is based on the sequence of nitrogen bases in DNA. The four bases make up the letters of the code. Groups of three bases each make up code words. These three-letter code words are called codons. Each codon stands for one amino acid or else for a start or stop signal. There are 20 amino acids that make up proteins. With three bases per codon, there are 64 possible codons. This is more than enough to code for the 20 amino acids plus start and stop signals. You can see how to translate the genetic code in Figure 5.17. Start at the center of the chart for the first base of each three-base codon. Then work your way out from the center for the second and third bases. Find the codon AUG in Figure 5.17. It codes for the amino acid methionine. It also codes for the start signal. After an AUG start codon, the next three letters are read as the second codon. The next three letters after that are read as the third codon, and so on. You can see how this works in Figure 5.18. The figure shows the bases in a molecule The genetic code has three other important characteristics. The genetic code is the same in all living things. This shows that all organisms are related by descent from a common ancestor. Each codon codes for just one amino acid (or start or stop). This is necessary so the correct amino acid is always selected. Most amino acids are encoded by more than one codon. This is helpful. It reduces the risk of the wrong amino acid being selected if there is a mistake in the code. The process in which proteins are made is called protein synthesis. It occurs in two main steps. The steps are transcription and translation. Watch this video for a good introduction to both steps of protein synthesis: [Link] MEDIA Click image to the left or use the URL below. URL: Transcription is the first step in protein synthesis. It takes place in the nucleus. During transcription, a strand of DNA is copied to make a strand of mRNA. How does this happen? It occurs by the following steps, as shown in Figure 5.19. 1. An enzyme binds to the DNA. It signals the DNA to unwind. 2. After the DNA unwinds, the enzyme can read the bases in one of the DNA strands. 3. Using this strand of DNA as
Question: _____any single-stranded nucleic acid | [
"rna"
] | task469-1204d24f0fa5497fad9072579cf53c3e | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: Your respiratory system is made up of the tissues and organs that allow oxygen to enter your body and carbon dioxide to leave your body. Organs in your respiratory system include your: Nose. Mouth. Larynx. Pharynx. Lungs. Diaphragm. The organs of the respiratory system move air into and out of the body. These structures are shown below (Figure 1.1). What do you think is the purpose of each of these organs? The nose and the nasal cavity filter, warm, and moisten the air you breathe. The nose hairs and the mucus produced by the cells in the nose catch particles in the air and keep them from entering the lungs. Behind the nasal cavity, air passes through the pharynx, a long tube. Both food and air pass through the pharynx. The larynx, also called the "voice box," is found just below the pharynx. Your voice comes from your larynx. Air from the lungs passes across thin tissues in the larynx and produces sound. The trachea, or windpipe, is a long tube that leads down to the lungs, where it divides into the right and left bronchi. The bronchi branch out into smaller bronchioles in each lung. There is small flap called the epiglottis that covers your trachea when you eat or drink. The muscle controlling the epiglottis is involuntary and prevents food from entering your lungs or wind pipe. The bronchioles lead to the alveoli. Alveoli are the little sacs at the end of the bronchioles (Figure 1.2). They look like little bunches of grapes. Oxygen is exchanged for carbon dioxide in the alveoli. That means oxygen enters the blood, and carbon dioxide moves out of the blood. The gases are exchanged between the blood and alveoli by simple diffusion. The diaphragm is a sheet of muscle that spreads across the bottom of the rib cage. When the diaphragm contracts, the chest volume gets larger, and the lungs take in air. When the diaphragm relaxes, the chest volume gets smaller, and air is pushed out of the lungs. "Grape-like" alveoli in the lungs.
Question: what part of the respiratory system serves as a filtering system, keeping certain particles out of the lungs? | [
"the nasal cavity"
] | task469-6410b65789bc4b85b453745dd2d10394 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: To compare the change of urethral mobility after midurethral sling procedures in stress urinary incontinence with hypermobile urethra and assess these findings with surgical outcomes. 141 women who agreed to undergo midurethral sling operations due to stress urinary incontinence with hypermobile urethra were enrolled in this non-randomized prospective observational study. Preoperatively, urethral mobility was measured by Q tip test. All women were asked to complete Urogenital Distress Inventory Short Form (UDI-6) and Incontinence Impact Questionnaire Short Form (IIQ-7) to assess the quality of life. Six months postoperatively, Q tip test and quality of life assessment were repeated. The primary surgical outcomes were classified as cure, improvement and failure. Transient urinary obstruction, de novo urgency, voiding dysfunction were secondary surgical outcomes. Of 141 women, 50 (35. 5%) women underwent TOT, 91 (64.5%) underwent TVT. In both TOT and TVT groups, postoperative Q tip test values, IIQ-7 and UDI-6 scores were statistically reduced when compared with preoperative values. Postoperative Q tip test value in TVT group was significantly smaller than in TOT group [25(15-45) and 20 (15-45), respectively]. When we compared the Q-tip test value, IIQ-7 and UDI-6 scores changes, there were no statistically significant changes between the groups. Postoperative urethral mobility was more frequent in TOT group than in TVT group (40% vs 23.1%, respectively). Postoperative primary and secondary outcomes were similar in both groups. Although midurethral slings decrease the urethtal hypermobility, postoperative mobility status of urethra does not effect surgical outcomes of midurethral slings in women with preoperative urethral hypermobility.
Question: Which type of urinary incontinence is diagnosed with the Q tip test? | [
"stress urinary incontinence"
] | task469-a9c18008458845e0b690b4cfad4c0495 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: After Alaungpaya's death, the new Burmese king Naungdawgyi was embroiled in several rebellions, including that of Gen. Minkhaung Nawrahta, and could not resume the war. The war was inconclusive. For all their work, the Burmese gained little of their original objectives. Siam very much remained a thorn to the stability of Burmese peripheral regions. In the following years, Siam continued to provide support to Mon rebels in the south who raised a major rebellion in 1762 as well as those in Lan Na in the north . The only lasting territorial gain the Burmese achieved was the upper Tenasserim coast, on which they previously had only a nominal claim. Although the Siamese troops no longer openly intruded the border, the Mon rebels continued to operate from the Siamese territory. In 1764, the Mon governor of Tavoy, who was made governor by Alaungpaya only four years earlier, revolted until it was put down in November 1764. Likewise, the instabilities in Lan Na resumed soon after the Burmese army left in February 1764, forcing the army to return again later in the year. The inconclusive nature of the war would lead to the next war in 1765.
Question: Which event happened first, the Burmese army left La Na, or the governor led a revolt? | [
"the burmese army left"
] | task469-72dc1b4cfda24bcea0f3d6035577a5e3 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: "Legend tells of a legendary warrior whose kung fu skills were the stuff of legend..." A mysterious panda donning a flowing cape and sedge hat walks through the Chinese landscape. Reputed to be a grand master of kung fu, he enters a tavern where he is immediately attacked by the local ruffians. However, they are no match for his skill and even the legendary kung fu masters, the Furious Five, bow down to the panda's skill, requesting to hang out with him and fight alongside him as......Po the giant panda (Jack Black) wakes up from his dream in his room. His goose father, Mr. Ping (James Hong) calls to him from the noodle restaurant below to help serve tables. Po admires his Furious Five action figures before going downstairs. An extreme fan of Kung Fu, Po dreams of one day becoming a master worthy of fighting alongside the Five but his girth and clumsiness makes this dream simply a dream and his kung fu talents reside only within his knowledge of moves and artifacts. He is hesitant to express his desires to his dad who is more interested in running his restaurant and advertising his famous 'secret ingredient soup'.Master Shifu (Dustin Hoffman), a red panda who resides at the Jade Palace temple, practices kung fu in the courtyard with his students, the Furious Five; Tigress (Angelina Jolie), Crane (David Cross), Monkey (Jackie Chan), Viper (Lucy Liu), and Mantis (Seth Rogen), before he is summoned to see tortoise Grand Master Oogway (Randall Duk Kim). Fearing something is wrong, Shifu rushes to find him meditating in the grand hall. Oogway doesn't deny bad news but calmly tells Shifu he's predicted that the snow leopard warrior Tai Lung (Ian McShane) will escape prison and return to the Valley of Peace to wreak destruction once again. Intent on never letting this happen, Shifu sends his goose messenger, Zeng (Dan Fogler), to fly to Chor-Gom Prison to ensure that security is increased. Oogway then proclaims that it is time to choose the Dragon Warrior; a master of great skill who will be granted the secrets of the universe by reading the Dragon Scroll, kept delicately out of reach on the temple ceiling. Assuming that one of the Furious Five will be chosen, Shifu prepares a competition to determine which one will qualify.Flyers for the competition are spread throughout town and the villagers flock to the temple. Excited to have the opportunity to see his idols in person, Po follows with his noodle cart in tow but struggles on the long staircase to the temple. He is the last to arrive at the gates and finds that they've shut him out. In a desperate bid to see the competition before it's over, Po fashions fireworks to his cart and blasts himself high into the air, only to come crashing down in the arena just as Oogway is preparing to choose out of the Five. Po opens his eyes to see Oogway's finger pointed right at him and is shocked, along with everyone else, when he is proclaimed to be the Dragon Warrior. Oogway's decision is final, despite Shifu's protests, and Po is carried (unsuccessfully) into the temple leaving Tigress greatly disappointed since it seemed Oogway would have chosen her if Po hadn't arrived.Inside the temple, Po examines, with awe, the many weaponry and valuable artifacts before Shifu approaches him and berates him for his obvious lack of skill. He deflates Po's excitement by grabbing his finger in what Po recognizes as the Wuxi Finger Hold, reputed to be extremely powerful. Shifu promises that Po will regret ever being chosen before taking him to the Fives training room where Po is promptly put to the test. Nervous, but excited to try some kung fu moves, Po accepts the challenge but is hurtled, flung, and beaten down to a now-existing Level 0.On the way to the dormitories, Po overhears the Five poke fun at his incompetence. He has an awkward conversation with Crane, opening up to his own doubts of being the Dragon Warrior. Tigress assures his doubts, calling him a disgrace to kung fu and tells
Question: What does Tai Lung use to defeat the Furious Five? | [
"wuxi finger hold",
"nerve strikes"
] | task469-1b5d1bd0bfa74592842dacf13d2e0cb8 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: When he was still a child, Iwatake's father was lost at sea off Hawaii. With no food, his family was forced to move to Japan, where Iwatake joined the army during the war. He lost a brother when the bomb fell on Hiroshima. But over all the time one thing has remained unchanged. His parents bought a Christmas tree in 1937, and his family brings it out every Christmas since then, even when doing so meat risking arrest. "This tree was a shining light, because it was a symbol of unity in my family," Iwatake said as he and his wife put the final touches on the tree, which is about 3 - foot - tall. They took it out once again this year, "We have put this tree up every year for 70 years." Though he considers himself Buddhist, Iwatake was raised in a Christian tradition. He still keeps a photo of the tiny wooden church in Mauri where he and his five brothers went to church services and Sunday school. Christmas was always a special time. His father worked at a store, and Iwatake remembers the day he came home with a tree. It was nothing all that special, just metal - and - plastic, the kind of decoration that can easily be placed on a table, or in a corner somewhere. He got a string of lights, too, the kind with the big bulbs . Soon after, his father died in a fishing accident. His body was never found. Iwatake's mother had s in Japan, and took Iwatake's younger brothers there. Iwatake stayed behind to graduate from high school. In 1941, six months before Pearl Harbor , he moved to Japan as well. "Things were bad," he said. "There were war clouds hanging everywhere."
Question: What caused the death of Iwatake's father? | [
"an accident."
] | task469-2f56e22b1d3f4a03be561b92a4d763ae | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: Kirby Air Ride, known in Japan as Kirby's Airride ( Kabi no Earaido), is a 2003 racing game video game developed by HAL Laboratory and published by Nintendo for the Nintendo GameCube video game console starring Kirby, one of HAL's characters.
Question: By whom was Kirby Air Ride developed? | [
"hal laboratory"
] | task469-da1f89660a12474aae856e81b2d0e10a | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: Common cellular and molecular mechanisms including protein aggregation and inclusion body formation are involved in many neurodegenerative diseases. -Synuclein is a major component of Lewy bodies in Parkinson's disease (PD) as well as in glial cytoplasmic inclusions in multiple system atrophy (MSA). Tau is a principal component of neurofibrillary and glial tangles in tauopathies. Recently, TDP-43 was identified as a component of ubiquitinated inclusions in amyotrophic lateral sclerosis and frontotemporal lobar degeneration. PD is traditionally considered a movement disorder with hallmark lesions in the brainstem pigmented nuclei. However, pathological changes occur in widespread regions of the central and peripheral nervous systems in this disease. Furthermore, primary glial involvement ("gliodegeneration") can be observed in PD and MSA as well as in tauopathy. The present article reviews abnormal protein accumulation and inclusion body formation inside and outside the central nervous system.
Question: Which is the primary protein component of Lewy bodies? | [
"αsyn",
"α-synuclein",
"alpha-synuclein"
] | task469-f2f3b2d6609f4f18902782dbc2554056 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: Rick Riker (Drake Bell) is an unpopular student at Empire High with his only friend Trey (Kevin Hart), living with his uncle Albert (Leslie Nielsen) and Aunt Lucielle (Marion Ross). His crush Jill Johnson (Sara Paxton), who hardly notices him, is dating Rick's bully Lance Landers (Ryan Hansen). Rick and Trey are then shown to be on a school trip to an animal research lab. In the lab Rick meets Lou Landers (Christopher McDonald) who coughs up blood because he is terminally ill. Dr. Strom, the head researcher at the lab, then shows his seven mutated dragonflies, though there are only six there because one has escaped which then bites Rick, and causes his neck to swell.The scene then goes to Rick's house where his Aunt Lucille and Uncle Albert are talking on the couch when Rick comes in. He is very sick, and throws up in a fish tank because of his illness and goes up to his room. Albert and Lucille believe Rick is acting strange, so Albert proceeds to talk to Rick. Rick then passes out from the bite.He wakes up the next morning, with a strange video sent to him from a man wanting to speak to him, later adding Rick as a friend on Facebook. Meanwhile, Lou Landers gets into a scientific accident, transforming into the Hourglass who feeds on human life. At a science fair, with a comically rude and mean-spirited Stephen Hawking who gets physically hurt throughout the film, Rick gets into mishaps, such as becoming stuck to water fountains. He then realizes he has superpowers such as the ability to walk on walls, has incredible strength, but cannot fly. He tests his strength in an alleyway, then decides to test how he can walk up walls. He climbs up and begins to break dance, then has a lie-down on the wall and a cat walks up the wall beside him. He then sees an old woman about to be hit by a truck in the road, and just as she is about to get hit he pushes her out of the way and the truck collides with him stopping it.After his heroic feat he is congratulated by passers-by, but as they are congratulating him he looks to his right and sees he has accidentally pushed the woman into a woodchipper and the dog she was holding the lead of up is slowly getting pulled up into the machine as well. Trey offers to become his sidekick, but Rick resigns. His Uncle and he have a brief fight, which reminds Rick when he was younger and rich with his parents who die in a spoof of Batman Begins. His father urges him to invest of all his money in, not Google, but Enron.Rick later watches the girl of his dreams, Jill, who leaves with Lance in his car. Rick wants a car, and he sets out to get money from the bank. He fails though, with no credit or payment.After his uncle is quickly injured, Rick is met by Xavier (Tracy Morgan) at his school for mutants ala X-Men. Rick is told to make a costume, which he does (and later improves), and he becomes known as the Dragonfly. He quickly becomes a sensation, until his fight with the Hourglass, who ends up cutting him with little hourglass blades. The Hourglass then escapes.Jill is then seen walking in an alleyway and is attacked by thugs, but the Dragonfly saves her. The two then try to kiss, but encounter difficulties as Dragonfly is hanging upside down. They eventually kiss for the first time, and Jill thanks him.The scene then goes to a Thanksgiving dinner at Rick's house. During Thanksgiving Landers visits the family (everyone is unaware he is Hourglass). He nearly catches Rick dressed as the Dragonfly, but later manages to figure out his secret identity.Just as Rick and Jill are about to fall in love, the Hourglass comes in and murders Aunt Lucille. After a comical funeral, Rick decides to throw in the towel as a superhero.Trey and Uncle Albert find Rick after the funeral
Question: Where is Rick a student at? | [
"empire high"
] | task469-80e60210877c41a5b110dfa452d14939 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: If the outside environment of a cell is water-based, and the inside of the cell is also mostly water, something has to make sure the cell stays intact in this environment. What would happen if a cell dissolved in water, like sugar does? Obviously, the cell could not survive in such an environment. So something must protect the cell and allow it to survive in its water-based environment. All cells have a barrier around them that separates them from the environment and from other cells. This barrier is called the plasma membrane, or cell membrane. The plasma membrane ( Figure 1.1) is made of a double layer of special lipids, known as phospholipids. The phospholipid is a lipid molecule with a hydrophilic ("water-loving") head and two hydrophobic ("water-hating") tails. Because of the hydrophilic and hydrophobic nature of the phospholipid, the molecule must be arranged in a specific pattern as only certain parts of the molecule can physically be in contact with water. Remember that there is water outside the cell, and the cytoplasm inside the cell is mostly water as well. So the phospholipids are arranged in a double layer (a bilayer) to keep the cell separate from its environment. Lipids do not mix with water (recall that oil is a lipid), so the phospholipid bilayer of the cell membrane acts as a barrier, keeping water out of the cell, and keeping the cytoplasm inside the cell. The cell membrane allows the cell to stay structurally intact in its water-based environment. The function of the plasma membrane is to control what goes in and out of the cell. Some molecules can go through the cell membrane to enter and leave the cell, but some cannot. The cell is therefore not completely permeable. "Permeable" means that anything can cross a barrier. An open door is completely permeable to anything that wants to enter or exit through the door. The plasma membrane is semipermeable, meaning that some things can enter the cell, and some things cannot. The inside of all cells also contain a jelly-like substance called cytosol. Cytosol is composed of water and other molecules, including enzymes, which are proteins that speed up the cells chemical reactions. Everything in the cell sits in the cytosol, like fruit in a jello mold. The term cytoplasm refers to the cytosol and all of the organelles, the specialized compartments of the cell. The cytoplasm does not include the nucleus. As a prokaryotic cell does not have a nucleus, the DNA is in the cytoplasm.
Question: in a prokaryotic cell, the dna is located in the _________. | [
"cytoplasm"
] | task469-1769d020f4274e7aab196d4328fa6f01 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: Simao Rodrigues de Azevedo (1510, Vouzela, Portugal - 15 June 1579, Lisbon), was a Portuguese Jesuit priest, , one of the co-founders of the Society of Jesus.
Question: To which religious order did Simao Rodrigues belong? | [
"society of jesus"
] | task469-e7d9625304b44f0babc57d9dca3990c5 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: The genetic disorders xeroderma pigmentosum (XP) and Cockayne syndrome (CS) exhibit deficiencies in the repair of UV-induced DNA damage. CS fibroblasts retain proficient nucleotide excision repair (NER) of inactive (or bulk) DNA, but are deficient in the transcription-coupled repair (TCR) of active genes. In contrast, XP complementation group C (XP-C) fibroblasts retain proficient TCR, but are deficient in bulk DNA repair. The remaining NER-deficient XP groups exhibit deficiencies in both repair pathways. Ad5HCMVsp1lacZ is a recombinant adenovirus vector that is unable to replicate in human fibroblasts, but can efficiently infect and express the beta-galactosidase reporter gene in these cells. We have examined the host cell reactivation (HCR) of beta-galactosidase activity for UV-irradiated Ad5HCMVsp1lacZ in non-irradiated and UV-irradiated normal, XP-B, XP-C, XP-D, XP-F, XP-G, CS-A and CS-B fibroblasts. HCR of beta-galactosidase activity for UV-irradiated Ad5HCMVsp1lacZ was reduced in non-irradiated cells from each of the repair-deficient groups examined (including XP-C) relative to that in non-irradiated normal cells. Prior irradiation of cells with low UV fluences resulted in an enhancement of HCR for normal and XP-C strains, but not for the remaining XP and CS strains. HCR of the UV-damaged reporter gene in UV-irradiated XP and CS strains was similar to measurements of TCR reported previously for these cells. These results suggest that UV treatment results in an induced repair of UV-damaged DNA in the transcribed strand of an active gene in XP-C and normal cells through an enhancement of TCR or a mechanism which involves the TCR pathway.
Question: Which gene strand is targeted by transcription-coupled repair (TCR)? | [
"the transcribed strand"
] | task469-d92a3087f9a64b8a80ed1ac88afa4187 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: The Urban 13 was a research-sharing association originally between thirteen public urban universities, but eventually grew to include 22 institutions when it was succeeded by the Great Cities' Universities coalition in 1998.
Question: Which replaced the Urban 13? | [
"great cities' universities"
] | task469-0682bd638c674e48891d85b4fd622e1d | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: The Toi invasion was the invasion of northern Kyushu by Jurchen pirates in 1019. At the time, Toi meant "barbarian" in the Korean language. The Toi pirates sailed with about 50 ships from direction of Goryeo, then assaulted Tsushima and Iki, starting 27 March 1019. After the Iki Island garrison comprising 147 soldiers was wiped out, the pirates has proceed to Hakata Bay. For a week, using Noko Island in the Hakata Bay as a base, they sacked villages and kidnapped over 1,000 Japanese, mostly women and young girls, for use as slaves. The Dazaifu, the administrative center of Kyushu, then raised an army and successfully drove the pirates away. During the second failed raid to Matsuura 13 April 1019, three enemies were captured by the Japanese army. They were identified as Koreans. They said that they had guarded the borderland but had been captured by the Toi. However, this was unlikely, and the Japanese officers suspected them because there had been Korean pirates attacking Japan coasts during the Silla period. A few months later, the Goryeo delegate Jeong Jaryang reported that Goryeo forces attacked the pirates off Wonsan and rescued about 260 Japanese. The Korean government then repatriated them to Japan where they were thanked by the Dazaifu and given rewards. There remain detailed reports by two captive women, Kura no Iwame and Tajihi no Akomi. These Jurchen pirates lived in what is today Hamgyongdo, North Korea.
Question: Which happend first, the assult of Tsushima and Iki, or the second raid to Matsuura? | [
"assaulted tsushima and iki,"
] | task469-176f80e852ab4b3e97a9ead14ab2e280 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: Over the next year, however, the Polish forces were subject to attrition, as the Sejm again refused to raise taxes and pay the army, resulting in mass desertions of unpaid soldiery. The Polish problems were further aggravated by the incompetent leadership of hetman Micha Kazimierz Pac, who obstructed Sobieski's leadership, while the Ottomans continued to receive reinforcements. Nonetheless in 1674 the Commonwealth resumed the offensive, taking advantage of a new Muscovy-Ottoman conflict that year, and the Polish-Ottoman war remained undecided.:275 Sobieski's force of 6,000 defeated 20,000 Turks and Tatars under Ibrahim Shyshman in the battle of Lwow in August 1675.:653 Even after the Battle of Trembowla, the Sejm still refused his pleas for more funds and a larger army.:653 In 1676, after Sobieski's 16,000 withstood the two-week siege of Zurawno, by 100,000 men under Ibrahim Pasha, a new peace treaty was signed, the Treaty of Zurawno.:655 The peace treaty partially reversing those from Buczacz: the Ottomans kept approximately two thirds of the territories they gained in 1672, and the Commonwealth no longer was obliged to pay any kind of tribute to the Empire; a large number of Polish prisoners were released by the Ottomans.
Question: Which came first, the Battle of Trembowla or the siege of A"urawno? | [
"battle of trembowla",
"the battle of trembowla"
] | task469-31b42c7245f54b06b765dba5a5e30eb9 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: A dedicated excision repair pathway, termed transcription-coupled repair (TCR), targets the removal of DNA lesions from transcribed strands of expressed genes. Transcription arrest at the site of the lesion has been proposed as the first step for initiation of TCR. In support of this model, a strong correlation between arrest of transcription by a lesion in vitro and TCR of that lesion in vivo has been found in most cases analyzed. TCR has been reported for oxidative DNA damage; however, very little is known about how frequently occurring and spontaneous DNA damage, such as depurination and base deamination, affects progression of the transcription complex. We have previously determined that the oxidative lesion, thymine glycol, is a significant block to transcription by T7 RNA polymerase (T7 RNAP) but has no detectable effect on transcription by RNA polymerase II (RNAP II) in a reconstituted system with all of the required factors. Another oxidative lesion, 8-oxoguanine, only slightly blocked T7 RNAP and caused RNAP II to briefly pause at the lesion before bypassing it. Because an abasic site is an intermediate in the repair of oxidative damage, it was of interest to learn whether it arrested transcription. Using in vitro transcription assays and substrates containing a specifically positioned lesion, we found that an abasic site in the transcribed strand is a 60% block to transcription by T7 RNAP but nearly a complete block to transcription by mammalian RNAP II. An abasic site in the nontranscribed strand did not block either polymerase. Our results clearly indicate that an abasic site is a much stronger block to transcription than either a thymine glycol or an 8-oxoguanine. Because the predominant model for TCR postulates that only lesions that block RNAP will be subject to TCR, our findings suggest that the abasic site may be sufficient to initiate TCR in vivo.
Question: Which gene strand is targeted by transcription-coupled repair (TCR)? | [
"the transcribed strand"
] | task469-7bd09624ac0f40118d30eee3a04cd305 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: Athens will welcome the 2004 Olympic Games with open arms. Not only will the Games be returning to their birthplace, but they'll also be entering a new period of Olympic history. The International Olympic Committee (IOC) has been looking for ways to make the world's largest sporting event a bit smaller and easier for cities to host. Mexico is the only Latin American nation to have hosted the Olympics. And the games have never been held in Africa. It costs well over$4 billion to host the Olympic Games. And this is stopping many poorer countries from trying to win the bid. Cities in Africa and Latin America, with great social and money problems, cannot even begin to make the bid. So, the IOC has suggested 117 ways to make the Games smaller and easier for cities across the world. These ideas are to be put into practice soon---maybe in time for the Beijing 2008 Olympics. The IOC wants to save up to $400 million. The suggestions include limiting the number of sports to 28 and the number of athletes to 10,500. "Imagine a bus with 28 seats and some sports need to get off to give their places to other sports,"said an IOC official. Sports that might not appear in the 2008 Beijing Olympic Games included baseball, softball and the modern pentathlon (shooting, fencing, horse, jumping, swimming and running). "We think that the Olympic Games have to be made smaller, and the less costly so that they can be organized by all continents and subcontinents ,"said IOC president Jacques Rogge. "Our dream is that a continent such as Africa will be able to organize the Olympic Games."
Question: What's the main idea of the passage? | [
"the olympic games have to be made smaller and less costly"
] | task469-ec1a6589fa7c43a5a5e025e93a44b2c0 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: A sexually transmitted infection (STI) is a disease that spreads mainly through sexual contact. STIs are caused by pathogens that enter the body through the reproductive organs. Many STIs also spread through body fluids such as blood. For example, a shared tattoo needle is one way that some STIs can spread. Some STIs can also spread from a mother to her infant during birth. STIs are more common in teens and young adults than in older people. One reason is that young people are more likely to engage in risky behaviors. They also may not know how STIs spread. Instead, they may believe myths about STIs, like those in Table 22.1. Knowing the facts is important to prevent the spread of STIs. Myth If you are sexually active with just one person, then you cant get STIs. If you dont have any symptoms, then you dont have an STI. Getting STIs is no big deal, because they can be cured with medicines. Fact The only sure way to avoid getting STIs is to practice abstinence from sexual activity. Many STIs do not cause symptoms, especially in fe- males. Only some STIs can be cured with medicines; others cannot be cured. A number of STIs are caused by bacteria. Bacterial STIs can usually be cured with antibiotics. However, some people with bacterial STIs may not have symptoms so they fail to get treatment. Left untreated, these infections may damage reproductive organs and lead to an inability to have children. Three bacterial STIs are chlamydia, gonorrhea, and syphilis. Chlamydia is the most common bacterial STI in the U.S. Females are more likely to develop it than males. Symptoms may include burning during urination and a discharge from the vagina or penis. Gonorrhea is another common bacterial STI. Symptoms may include painful urination and a discharge from the vagina or penis. Syphilis is a very serious STI but somewhat less common than chlamydia or gonorrhea. It usually begins with a small sore on the genitals. This is followed a few months later by a rash and flu-like symptoms. If syphilis isnt treated, it can eventually damage the heart, brain, and other organs and even cause death. Several STIs are caused by viruses. Viral STIs cant be cured with antibiotics. Other drugs may help control the symptoms of viral STIs, but the infections usually last for life. Three viral STIs are genital warts, genital herpes, and AIDS. Genital herpes is a common STI caused by a herpes virus. The virus causes painful blisters on the penis or near the vaginal opening. The blisters generally go away on their own, but they may return repeatedly throughout life. There is no cure for genital herpes, but medicines can help prevent or shorten outbreaks. Acquired Immunodeficiency Syndrome (AIDS) is caused by human immunodeficiency virus (HIV). HIV destroys lymphocytes that normally fight infections. AIDS develops if the number of lymphocytes drops to a very low level. People with AIDS come down with diseasessuch as certain rare cancersthat almost never occur in people with a healthy immune system. Medicines can delay the progression of an HIV infection and may prevent AIDS from developing. Genital warts is an STI caused by human papilloma virus (HPV), which is pictured in Figure 22.15. This is one of the most common STIs in U.S. teens. Genital warts cant be cured, but a vaccine can prevent most HPV infections. The vaccine is recommended for boys and girls starting at 11 or 12 years of age. Its important to prevent HPV infections because they may lead to cancer later in life. Other reproductive system disorders include injuries and noninfectious diseases. These are different in males and females. Most common disorders of the male reproductive system involve the testes. They include injuries and cancer. Injuries to the testes are very common. In teens, such injuries occur most often while playing sports. Injuries to the testes are likely to be very painful and cause bruising and swelling. However, they generally subside fairly quickly. Cancer of the testes is most common in males aged 15 to 35. It occurs when cells in the testes grow out of control and form a tumor. If found early
Question: __viral STI that can be prevented with a vaccine | [
"genital warts"
] | task469-f720f9d6ed4b438586f1c163b1c4c83f | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: Research during the last 15 years has conclusively shown that viroids are not only fundamentally different from viruses at the molecular level, but that they are most likely not directly related to viruses in an evolutionary sense. Today, viroids are among the most thoroughly studied biological macromolecules. Their molecular structures have been elucidated to a large extent, but much needs to be learned regarding the correlation between molecular structure and biological function. The availability of the tools of recombinant DNA technology in viroid research promises rapid progress in these areas of inquiry.
Question: Which are the smallest known subviral pathogens of plants? | [
"viroids"
] | task469-bacd63503e2b4945b97e28b6c6ffa7e2 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: Peroxiredoxin 2 (Prx2) is an antioxidant enzyme that uses cysteine residues to decompose peroxides. Prx2 is the third most abundant protein in erythrocytes, and competes effectively with catalase and glutathione peroxidase to scavenge low levels of hydrogen peroxide, including that derived from hemoglobin autoxidation. Low thioredoxin reductase activity in the erythrocyte is able to keep up with this basal oxidation and maintain the Prx2 in its reduced form, but exposure to exogenous hydrogen peroxide causes accumulation of the disulfide-linked dimer. The high cellular concentration means that although turnover is slow, erythrocyte Prx2 can act as a noncatalytic scavenger of hydrogen peroxide and a sink for hydrogen peroxide before turnover becomes limiting. The consequences of Prx2 oxidation for the erythrocyte are not well characterized, but mice deficient in this protein develop severe hemolytic anemia associated with Heinz body formation. Prx2, also known as calpromotin, regulates ion transport by associating with the membrane and activating the Gardos channel. How Prx2 redox transformations are linked to membrane association and channel activation is yet to be established. In this review, we discuss the functional properties of Prx2 and its role as a major component of the erythrocyte antioxidant system.
Question: What type of enzyme is peroxiredoxin 2 (PRDX2)? | [
"antioxidant"
] | task469-474a9465391f416c85b6b52da388d960 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
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