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Context: Transcription factors of the NFAT (nuclear factor of activated T cells) family are expressed in most immune system cells and in a range of other cell types. Signaling through NFAT is implicated in the regulation of transcription for the immune response and other processes, including differentiation and apoptosis. NFAT normally resides in the cytoplasm, and a key aspect of the NFAT activation pathway is the regulation of its nuclear import by the Ca(2+)/calmodulin-dependent phosphatase calcineurin. In a cell line stably expressing green fluorescent protein (GFP)-NFAT, this import can be triggered by elevation of intracellular calcium and visualized in live cells. Here we show that the inducible nuclear import of GFP-NFAT is efficiently blocked at early stages of herpes simplex virus (HSV) infection. This is a specific effect, since we observed abundant nuclear accumulation of a test viral protein and no impediment to general nuclear localization signal-dependent nuclear import and retention in infected cells. We show that virus binding at the cell surface is not itself sufficient to inhibit the signaling that induces NFAT nuclear translocation. Since the block occurs following infection in the presence of phosphonoacetic acid but not cycloheximide, we infer that the entry of the virion and early gene transcription are required but the effect is independent of DNA replication or late virus gene expression. A consequence of the block to GFP-NFAT import is a reduction in NFAT-dependent transcriptional activation from the interleukin-2 promoter in infected cells. This HSV-mediated repression of the NFAT pathway may constitute an immune evasion strategy or subversion of other NFAT-dependent cellular processes to promote viral replication.
Question: Which calcium/calmodulin dependent protein phosphatase is involved in the activation of the family of NFAT transcription factors (Nuclear Factors of Activated T cells)? | [
"can",
"calcineurin",
"phosphatase 2b"
] | task469-0d05d6f2dbde42309f5d78496a1715a3 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: Ataxin-3 (AT3) is the protein that triggers the inherited neurodegenerative disorder spinocerebellar ataxia type 3 when its polyglutamine (polyQ) stretch close to the C-terminus exceeds a critical length. AT3 consists of the N-terminal globular Josephin domain (JD) and the C-terminal disordered one. It cleaves isopeptide bonds between ubiquitin monomers, an event involved in protein quality control mechanisms. AT3 has been implicated in the pathway that sorts aggregated protein to aggresomes via microtubules, in which dynein and histone deacetylase 6 (HDAC6) also seem to be involved. By taking advantage of small angle X-ray scattering (SAXS) and surface plasmon resonance (SPR), we have investigated the interaction of AT3 with tubulin and HDAC6. Based on SAXS results, the AT3 oligomer, consisting of 6-7 subunits, tightly binds to the tubulin hexameric oligomer in a "parallel" fashion. By SPR analysis we have demonstrated that AT3 binds to tubulin dimer with a 50nM affinity. Binding fits with a Langmuir 1:1 model and involves a single binding interface. Nevertheless, the interaction surface consists of three distinct, discontinuous tubulin-binding regions (TBR), one located in the JD, and the two others in the disordered domain, upstream and downstream of the polyQ stretch. In the absence of any of the three TBRs, the affinity is drastically reduced. By SPR we have also provided the first evidence of direct binding of AT3 to HDAC6, with affinity in the range 0.1-1M. These results shed light on the interactions among the components of the transport machinery that sorts aggregate protein to the aggresome, and pave the way to in vivo studies aimed at further clarifying their roles.
Question: Which is the protein implicated in Spinocerebellar ataxia type 3? | [
"ataxin-3"
] | task469-c6bb68467d6b4a03b7ce495d34036b2c | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: Can you name some fossils? How about dinosaur bones or dinosaur footprints? Animal skeletons, teeth, shells, coprolites (otherwise known as feces), or any other remains or traces from a living creature that becomes rock is a fossil. The same processes that formed these fossils also created some of our most important energy resources, fossil fuels. Coal, oil, and natural gas are fossil fuels. Fossil fuels come from living matter starting about 500 million years ago. Millions of years ago, plants used energy from the Sun to form sugars, carbohydrates, and other energy-rich carbon compounds. As plants and animals died, their remains settled on the ground on land and in swamps, lakes, and seas (Figure 1.1). Over time, layer upon layer of these remains accumulated. Eventually, the layers were buried so deeply that they were crushed by an enormous mass of earth. The weight of this earth pressing down on these plant and animal remains created intense heat and pressure. After millions of years of heat and pressure, the material in these layers turned into chemicals called hydrocarbons (Figure 1.2). Hydrocarbons are made of carbon and hydrogen atoms. This molecule with one carbon and four hydrogen atoms is methane. Hydrocarbons can be solid, liquid, or gaseous. The solid form is what we know as coal. The liquid form is petroleum, or crude oil. Natural gas is the gaseous form. The solar energy stored in fossil fuels is a rich source of energy. Although fossil fuels provide very high quality energy, they are non-renewable. Click image to the left or use the URL below. URL:
Question: what is the biggest downside our dependence on fossil fuels for energy? | [
"they are non-renewable."
] | task469-b1f7db82f0aa4294bc9e6318e31352e3 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: Sir Lionel is the younger son of King Bors of Gaunnes (or Gaul) and Evaine and brother of Bors the Younger in Arthurian legend.
Question: Who was the brother of Sir Lionel? | [
"bors"
] | task469-ddcc8b1c21d148ad95ddc8a98144c72d | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: The company "Spacely Sprockets and Spindles" is in dire trouble. Their latest project, dubbed the 'Orbiting Ore Asteroid,' has had numerous technical setbacks, doing only 3 days of work in over 6 months. To make matters worse, the vice-president in charge of operations, Alexander Throttle-bottom, has run off, making this the fourth vice-president that the operation has lost. Matters are further compounded when the site's assistant refuses to press the start button to activate the factory, or accept Spacely's offer for a promotion or raise.Using his secretarial computer, Spacely pegs George Jetson to be the new vice-president, sending George home to pack and tell his family. However, the news is met with with sadness, as the move will interfere with Jane's recycling program, Elroy's spaceball tournament, and Judy's date with rock star Cosmic Cosmo.Even so, the family manages to come together (with the exception of Judy who is sad about her missed date), and the family arrives at the 'Orbiting Ore Asteroid,' which not only houses the factory, but a shopping center and housing complex. The Jetsons meet their new neighbors, including Lucy-2, whose husband Rudy-2 works at the factory, and son Teddy-2 plays on the local spaceball team. They also meet the Furbolo family, including their mischievous daughter, Fergie.The next day, George arrives at work and meets Rudy-2. Rudy verses George on the factory equipment, and they prepare for the official start-up of the factory. Meanwhile, Jane and Judy go shopping with Lucy-2. Still feeling depressed, Judy goes off on her own, and meets a boy named Apollo Blue, whom she quickly develops a crush on.Later on that day, everyone turns out for the re-opening of the plant, with George activating the controls. However, the machine malfunctions again, irritating Spacely. Shortly thereafter, Rudy-2 reveals to George about previous technical issues with the plant, and cautions that it may be safer if George were to go home. George refuses, not wanting to give up on being vice-president. The next day, repairs appear to be made but the factory again malfunctions. Spacely blames George for the technical glitches, and leaves Earth to check on the factory.After inspecting the factory again, Rudy-2 reveals that the incidents do not appear to be accidents, but 'warnings' to shut down the plant. Rudy then explains about the factory's troubles, and of the 4 previous vice-presidents. George decides to stay overnight at the plant, and figure out just what is happening.Elroy and Teddy-2 sneak off to follow him. However, when their disappearance is found out, Jane asks Judy and Apollo Blue to try and find them. Judy and Apollo find both Elroy and Teddy-2 at the plant, along with Fergie, who tagged along. They also find a strange little creature, whose species Fergie identifies as a Grungee. The Grungee leads them into the core of the asteroid, where it is revealed why the factory keeps being sabotaged: The factory's enormous drill is destroying the Grungee's habitat in the base of the asteroid. The Grungees have been making the plant malfunction to keep their homes from being destroyed.Jane and Astro soon make their way into the factory, along with Rudy-2. Rudy stays in the factory, as Jane and Astro go below. Soon afterwards, they all find George, who had been bound and gagged by the Grungees. George has no idea why this has happened to him, untill Jane and the others explain.Shortly after this revelation, Mr Spacely arrives, and against Rudy-2's protestations, reactivates the drill, almost killing Elroy when it's actions cause a large amount of rock to collapse. The other Grungees manage to help him, and they all head top-side. After Mr Spacely refuses to stop the drill, George manage to make the system malfunction. When Spacely demands an explanation, George explains about the Grungees, and Spacely is soon found to have ignored reports that the asteroid was inhabited.A deal is made by which the Grungees operate the plant,
Question: who is Teddy-2's father? | [
"rudy-2"
] | task469-0564e3e0ff904d66bf29c3b2ba297762 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: The Panthers went into the fourth quarter with a 17-3 lead over the Chiefs but things changed when Cairo Santos kicked a field goal, and Eric Berry had a pick six. Santos makes another field goal, tying the game at 17. In the Panthers' last possession of the game, the ball was stripped out of Kelvin Benjamin's hands and Kansas City gets the ball back. Santos makes the game-winning field goal for the Chiefs, and the Panthers fall to 3-6.
Question: Which player returned an interception for a touchdown? | [
"eric berry"
] | task469-c8ffeeed8ce640e8b498d27ed6ec5d51 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: John Fletcher Clews Harrison (usually cited as John Fletcher Clews Harrison or J. F. C. Harrison; born 28 February 1921) is Emeritus Professor of History at the University of Sussex and author of books on history, particularly relating to Victorian Britain.
Question: What is J. F. C. Harrison's place of employment? | [
"university of sussex"
] | task469-8c206a1b0c204b369336d851ffbea30d | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: The film opens with an animated prologue revealing the origins of leprechauns, stating that they were summoned by a king to protect his gold from those who would try to steal it. After the death of the king the Leprechauns returned to their places of origin, all except one (Warwick Davis) who remained in the mortal world and through the ages slowly became corrupted and obsessed with the treasure he still guarded. In the present Father Jacob (Willie C. Carpenter) is chased through the construction site of the youth center he had planned on building by the Leprechaun, whose gold Jacob had taken to fund the building project. Using four-leaf clover laced holy water Jacob manages to banish the Leprechaun, summoning demonic hands which drag him underground, but soon after drops dead of injuries inflicted by the Leprechaun during the fight.One year later two down on their luck friends Emily Woodrow (Tangi Miller) and Lisa Duncan (Sherrie Jackson) have their fortune told when the clairvoyant Esmeralda (Donzaleigh Abernathy) who warns them that they will attain great wealth soon, but it must be denied as it will come at a great price and summon a terrible evil. While having a barbecue at the abandoned youth center construction site with Lisa, their stoner friend Jamie Davis (Page Kennedy) and her ex-boyfriend turned drug dealer Rory Jackson (Laz Alonso) Emily falls through a hole and discovers the Leprechaun's gold in an old tunnel where it was hidden by Father Jacob. Splitting up the gold (which is produced in a never ending amount by the chest it was contained in) evenly the quartet of friends use it to fulfill their fantasies, unaware that by taking the gold they have released the Leprechaun, who begins stalking the group (killing a guest who takes one of his coins at a party held by Jamie, prompting the police to temporarily arrest him). At the salon where Emily works the Leprechaun sneaks in and, after killing a regular customer, Doria, on the massage table by breaking her neck, attacks Emily, who barely escapes and warns Rory and the recently released Jamie, who rush to get to Lisa's. In her house Lisa is attacked by the Leprechaun and manages to fight him off for a short while, but is killed when the Leprechaun claws her in the stomach, with her friends finding her body moments later.While Emily and Jamie want to return the gold Rory does not and takes off with it; shortly after realizing Rory is gone Emily is attacked and chased outside by the Leprechaun, but is saved when Rory has a change of heart and comes back for her. Searching for Rory the Leprechaun stops by his house and kills Rory's profligate girlfriend Chanel (Keesha Sharp) by tearing out her upper jaw, reclaiming the gold she used to make a tooth while Rory and Emily are stopped and harassed by Officers Thompson (Beau Billingslea) and Whitaker (Chris Murray). After the Leprechaun appears and kills the two officers Emily and Rory escape and regroup with Jamie, only to be confronted by a machine gun wielding group of Rory's drug dealing rivals, led by Watson (Shiek Mahmud-Bey) and Cedric (Sticky Fingaz). Planning on executing Rory for infringing on their territory Watson and his gang are all disposed of by the Leprechaun, (who kills Watson and Cedric while the other two members run off) while Emily, Rory and Jamie drive off in Watson's car (which the Leprechaun latches to the bottom of for a short while) and go looking for help from Esmeralda.Advised to use four-leaf clovers against the Leprechaun by Esmeralda, Rory laces the hollow-point bullets of his gun with clovers Jamie finds in the marijuana Rory had earlier sold him. When the Leprechaun arrives Rory shoots him several times with the clover bullets, only for his gun to jam before he can finish the Leprechaun off. Rory and Emily are given the chance to run with the gold when the Leprechaun is distracted by Jamie and Esmeralda (the latter dying in a magical duel with the Leprechaun). Followed to the roof of the building Rory tries fighting the Leprechaun and is knocked out, though before the Leprechaun can kill him
Question: Why does a machine gun wielding group of Rory's drug-dealing rivals confront the group? | [
"planning on executing rory for infringing on their territory"
] | task469-13418f5485ea4ee7aa10fdfcb862bb61 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: In late July, Danzig was re-inforced by a Dutch garrison, and a combined Danish and Dutch fleet broke the naval blockage imposed on Danzig by Charles X Gustav. On 28-30 July, a combined Brandenburgian-Swedish army was able to defeat the Polish-Lithuanian army in the Battle of Warsaw, forcing John II Casimir to retreat to Lublin. In August, Alexis' army took Livonian Kokenhausen , laid siege to Riga and Dorpat and raided Estonia, Ingria and Kexholm. On 4 October, John II Casimir stormed eczyca in Greater Poland before heading for Royal Prussia, and on 8 October, Wincenty Korwin Gosiewski with 12,000 to 13,000 Lithuanian and Crimean Tartar cavalry overran a Brandenburgian-Swedish force in the Battle of Prostken in Ducal Prussia. Gosiewski then ravaged Ducal Prussia, burning 13 towns and 250 villages, in a campaign that entered folklore because of the high death toll and the high number of captives deported to the Crimea. On 22 October, Gosiewski was defeated by Swedish forces in the Battle of Filipow and turned to Lithuania. Also on 22 October, besieged Dorpat surrendered to Alexis, while the Russian siege of Swedish-held Riga was lifted. John II Casimir meanwhile took Bromberg and Konitz in Royal Prussia, and from 15 November 1656 until February 1657 stayed in Danzig, where a Swedish siege had to be lifted due to Dutch intervention, just 55 kilometers away from Charles X Gustav's quarters in Elbing.
Question: Gosiewski ravaged Ducal Prussia for what reason? | [
"burning 13 towns"
] | task469-27c76bce65a54ab78efbeaf3a37d5122 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
Context: Energy from the Sun comes from the lightest element, hydrogen, fusing together to create the second lightest element, helium. Nuclear fusion on the Sun releases tremendous amounts of solar energy. The energy travels to the Earth, mostly as visible light. The light carries the energy through the empty space between the Sun and the Earth as radiation. Solar energy has been used for power on a small scale for hundreds of years, and plants have used it for billions of years. Unlike energy from fossil fuels, which almost always come from a central power plant or refinery, solar power can be harnessed locally (Figure 1.1). A set of solar panels on a homes rooftop can be used to heat water for a swimming pool or can provide electricity to the house. Societys use of solar power on a larger scale is just starting to increase. Scientists and engineers have very active, ongoing research into new ways to harness energy from the Sun more efficiently. Because of the tremendous amount of incoming sunlight, solar power is being developed in the United States in southeastern California, Nevada, and Arizona. Solar panels supply power to the Interna- tional Space Station. Solar power plants turn sunlight into electricity using a large group of mirrors to focus sunlight on one place, called a receiver (Figure 1.2). A liquid, such as oil or water, flows through this receiver and is heated to a high temperature by the focused sunlight. The heated liquid transfers its heat to a nearby object that is at a lower temperature through a process called conduction. The energy conducted by the heated liquid is used to make electricity. This solar power plant uses mirrors to focus sunlight on the tower in the center. The sunlight heats a liquid inside the tower to a very high temperature, producing energy to make electricity. Solar energy has many benefits. It is extremely abundant, widespread, and will never run out. But there are problems with the widespread use of solar power. Sunlight must be present. Solar power is not useful in locations that are often cloudy or dark. However, storage technology is being developed. The technology needed for solar power is still expensive. An increase in interested customers will provide incentive for companies to research and develop new technologies and to figure out how to mass-produce existing technologies (Figure 1.3). Solar panels require a lot of space. Fortunately, solar panels can be placed on any rooftop to supply at least some of the power required for a home or business. This experimental car is one example of the many uses that engineers have found for solar energy. Click image to the left or use the URL below. URL: Click image to the left or use the URL below. URL:
Question: the source of solar power is nuclear | [
"fusion."
] | task469-49599bdba9754cf8bfa012dce20f9a02 | question_answering | [
"Wikipedia",
"News",
"Natural Science"
] | mrqa | task469_mrqa_answer_generation | english |
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