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A 13-year-old boy was diagnosed as acute lymphoblastic leukemia following radiotherapy and chemotherapy for treatment of medulloblastoma.
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Representative cases illustrate the clinical manifestations of chemoradiation on the developing dentition.
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We report a case of a 32-year-old man who showed paradoxical enlargement of pathologically verified intracranial tuberculomas during a course of adequate antituberculous chemotherapy.
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She died 10 days after treatment was begun.
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Thus, tardive seizures in our cases are thought to be related to piperacillin and cefotiam.
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These observations have been reflected in postmarketing clinical experience, leading to recommendations that novel antipsychotics, such as sertindole, should be prescribed to first-episode patients.
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There are few reported findings of sexual dysfunction in men and none in women.
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Despite subsequent investigations, including analysis of urinary metabolites of organic and amino acids, measurement of serum carnitine and a muscle biopsy, we could not clarify the primary metabolic abnormalities in this girl.
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Unfortunately, the patient went to another hospital located in the small city where she lived, and all remaining doses of the total course of treatment were administered over the next 5 consecutive days, with no interruption in therapy.
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Range orders for the delivery of IV opioids give nurses the flexibility needed to treat patients' pain in a timely manner while allowing for differences in patient response to pain and to analgesia.
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Benzalkonium chloride poisoning in infant twins.
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Soon afterwards he developed cholestatic hepatitis and visual disturbance.
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To our knowledge, this is the only reported case of tularemia occurring in the post-transplant setting.
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After the withdrawal of TMP-SMX and the administration of high-dose steroid, these systemic symptoms gradually resolved.
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Epidural abscess and meningitis, a complication of spinal anesthesia in a bacteraemic patient.
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Disseminated cysticercosis.
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Less common adverse events to dapsone include the idiosyncratic reactions of leukopenia and agranulocytosis, cutaneous eruptions, peripheral neuropathy, psychosis, toxic hepatitis, cholestatic jaundice, nephrotic syndrome, renal papillary necrosis, severe hypoalbuminemia without proteinuria, an infectious mononucleosis-like syndrome, and minor neurological and gastrointestinal complaints.
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Complete physical recovery occurred after several days of supportive treatment.
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Differential diagnosis and treatment of this condition are discussed.
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The diagnosis of sepsis and submandibular phlegmon was confirmed by a positive blood culture for serotype III group B Streptococcus agalactiae.
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The patient experienced muscle twitches, tremulousness, and anxiety on day 17 of foscarnet therapy.
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After the institution of the combined therapy with corticosteroid, anticoagulant, and dipyridamole, urinary protein excretion was attenuated to less than 1.0 g/day.
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CASE SUMMARY: A 75-year-old man developed agitation, confusion, incoordination, and gait disturbance because of progressive rigidity.
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We report for the first time on a patient who had isolated aspergillosis of the small bowel after autologous stem cell transplantation.
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Sulfasalazine-induced lung disorder is an extremely rare entity which must be considered in all ulcerative colitis patients while on sulfasalazine therapy, despite the absence of pulmonary symptomatology.
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Case 2, a 29-year-old woman, developed bilateral optic neuritis combined with numbness of the lower extremities as well as bowel and bladder dysfunction after a 22-month use of recombinant interferon alpha-2b for chronic myelogenous leukemia.
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A dapsone hypersensitivity syndrome, consisting of fever, headache, nausea, vomiting, lymphadenopathy, hepatitis, hemolysis, leukopenia, and mononucleosis, has been described in patients treated with the drug for leprosy.
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Among these are an increased incidence of both gram-positive and gram-negative infections and an increased incidence of gastrointestinal symptoms.
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Clinical course of macular edema in two cases of interferon-associated retinopathy observed by optical coherence tomography.
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A 63-year-old woman with seropositive rheumatoid arthritis was successfully treated with auranofin for 12 months.
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Patients may not mention it among their medicines, since it is so commonly used and they regulate it themselves.
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Visual changes, headache, and elevated blood pressures were present on arrival to the emergency department.
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Clinicians should monitor patients closely for a decreased VPA effect when these medications are given concomitantly.
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It is important that nurses understand potential side effects of these agents, know of possible interventions, and participate in research to identify effective interventions.
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In this report the case of a 58-year-old female with neuropathic pain using increasing transdermal (TTS) fentanyl dosages to a maximum dose of 3400 microg/h resulting in fentanyl plasma levels of 173 ng/ml is described.
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The main objective of this report is to compare and contrast the type and frequency of neuropathological findings following liver, heart, lung, heart-lung, kidney and bone marrow transplantation and to provide an overview of the major systemic complications in patients that received allografts.
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It is suggested this relationship is causal rather than coincidental and mediated through cerebral arterial vasodilatation.
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Early recognition of this condition and initiation of effective treatment can improve outcome.
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Side effects associated with this medication are usually minor; serious complications are most often due to the delivery system required for continuous infusion.
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RESULTS: Visual loss was mild and generally nonprogressive.
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Here we report a patient with newly diagnosed acute promyelocytic leukemia who developed acute focal myositis, synovitis, and possible vasculitis, after receiving all-trans retinoic acid therapy.
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Drug induced polymyositis secondary to leuprolide acetate (Lupron) therapy for prostate carcinoma.
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The cystic larval forms (coenuri) are found in hares, rabbits, squirrels, and, rarely, in humans.
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2-Chloro-deoxyadenosine induces durable complete remission in Castleman's disease but may accelerate its transformation to non-Hodgkin's lymphoma.
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In our patient, symptoms were most acute during the infusion, when whole blood cyclosporine concentrations were likely to be the highest.
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One patient developed large intramural esophageal hematoma as a complication of heparin therapy.
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In patients with inflammatory bowel disease cytomegalovirus infection has been described in both immunocompetent and immunocompromised individuals.
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The main clinical features of this 58-year-old female patient were laboratory evidence of leucopenia and cholestasis, and biopsy features of fatty liver parenchyma degeneration with granulocytic portal infiltration and bile stasis, demonstrated 20 days after the initiation of antithyroid therapy with 20 mg methimazole daily.
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Potential interaction between azithromycin and warfarin.
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Colchicine-induced rhabdomyolysis.
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Pulmonary lymphohistiocytic reactions temporally related to etanercept therapy.
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PURPOSE: To determine the cause of spontaneous choroidal hemorrhage in a 67-year-old man after a myocardial infarction and administration of tissue plasminogen activator.
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A well-recognized complication of ethambutol use is optic neuropathy, but the potential ocular toxicity of isoniazid is often overlooked.
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In particular, this adverse effect has never been described with mefloquine (Lariam).
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DESIGN: Morphologic, immunophenotypic, and cytogenetic analyses were performed on the 3 patients at the time of initial diagnosis, during imatinib therapy, and at blast crisis.
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Upon admission, all drugs were continued except metoclopramide.
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Features of both de novo AML [FAB M2 morphology, t(8;21), and "secondary leukemia" (additional cytogenetic changes, resistance to chemotherapy) were present.
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A 57-year-old man developed morphea while taking bromocriptine.
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Gold nephropathy due to auranofin obscured by tolmetin pseudoproteinuria.
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The possible causes of this previously unreported early complication are discussed.
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No hematologic or blood chemistry abnormalities related to L-AmpB treatment were observed.
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A macrophage activation syndrome, possibly related to methotrexate toxicity, developed in a boy with systemic juvenile rheumatoid arthritis.
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In one patient, APL developed 21 months after liver transplantation for ornithine transcarbamylase deficiency.
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Other related symptoms presented by our patient were mood fluctuation and increased writing activity suggestive of punding.
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The case illustrates the classic features of the syndrome and its dramatic response to corticosteroid treatment.
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A 36-year-old man being treated with cisplatinum, vinblastine, and bleomycin for testicular carcinoma developed a dense left homonymous hemianopsia, encephalopathy, and a partial nondominant parietal lobe syndrome.
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The condition should be suspected in patients who develop unexplained abdominal pain or collapse following vasopressin treatment.
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RESULTS: Parathyroid hormone, parathyroid hormone-related peptide and 1,25-dihydroxyvitamin D levels were suppressed, suggesting that hypercalcemia was mediated through alternative mechanisms.
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We report the case of a young man, affected by rheumatoid arthritis who developed a rapid-onset short-of-breath, hemoptysis, and severe weakness, about 2 weeks after the administration of leflunomide.
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Fournier's gangrene is a fulminant necrotizing fasciitis of the scrotum and penis, often with an infectious etiology.
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A new sodium homoeostasis was established with a higher dose of DDAVP.
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Photochemotherapy with psoralens and UVA (PUVA) is widely used in the treatment of psoriasis and many other skin conditions.
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A 33-year-old man with a history of recreational benztropine abuse presented to the emergency department with confusion, abdominal pain, and distention.
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High-density lipoprotein levels increased in both patients.
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We report the case of an elderly patient who developed this unusual occurrence following an uneventful pars plana vitrectomy for a posteriorly dislocated IOL.
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A cytogenetic study showed del (3)(q11.1).
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The cyst can rupture and with the pre-existing steroid induced immune-suppression, the calf abscess will be hard to control.
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The other patient was treated with amphotericin B and discharged, with a central venous catheter, after recovery from neutropenia.
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A 67-year-old man on long-term carbamazepine therapy underwent elective coronary artery bypass grafting.
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Semiselective intra-arterial chemotherapy with compression of the femoral arteries at the time of injection.
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CT scan of the brain was unremarkable.
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Most often the myeloblastic form of acute leukemia was diagnosed.
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Subsequently he had severe hyperphosphatemia (29.3 and 14.1 mg/dl; 9.46 and 4.55 mmol/L), hypocalcemia, hyperuricemia, hyperkalemia, and azotemia.
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Our results suggest that rituximab and possibly irradiated DLI played an important role in controlling early EBV-LPD in these two patients and may be an effective alternative therapeutic strategy for patients who develop EBV-LPD post transplant and are unable to receive unmanipulated DLI.
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Intraocular infection due to Blastomyces dermatitidis is rare, and only 10 cases have previously been reported.
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Repeat courses may be needed to eradicate infection.
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A case of acute pleuropericarditis, which occurred after apparently successful percutaneous coronary intervention (PCI) for chronic total occlusion of the right coronary artery, is reported.
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Chronic, low-grade endophthalmitis after cataract surgery with intraocular lens (IOL) implantation is often unresponsive to antibiotic therapy, probably because of low drug penetration into the capsular bag.
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Lithium-induced Creutzfeldt-Jakob syndrome.
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Complications of extensive adhesion formation after intraperitoneal chemotherapy.
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Tigecycline-induced acute pancreatitis: case report and literature review.
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The patient, a paraplegic, was treated with dantrolene and made a full recovery.
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Furthermore, the dystonia may resolve following the disappearance of the brainstem and thalamic lesions.
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Amiodarone was approved to treat recurrent ventricular fibrillation or sustained ventricular tachyarrhythmia that has been resistant to other medications since 1986.
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Injury of the inferior alveolar nerve after overfilling of the root canal with endodontic cement: a case report.
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Acyclovir was discontinued.
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The patient was hospitalized in October, 1974, with signs and symptoms of right ventricular outflow obstruction and arrhythmia, and cardiac workup established the presence of a right ventricular tumor.
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As part of the comprehensive treatment, strict reverse isolation and granulocyte-macrophage colony-stimulating factor (GM-CSF) therapy were applied.
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The clinical course suggested that recombinant alpha-2b peginterferon plus ribavirin provoked type 1 diabetes mellitus, therefore, in patients who are candidates for interferon therapy the presence of pancreatic autoantibodies and the fasting plasma glucose level should be investigated before and during treatment.
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Six months before cessation of therapy discrete radiological signs of apical fibrosis appeared.
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