text
stringlengths 57
1.72k
| relation
stringclasses 125
values | h
dict | t
dict |
|---|---|---|---|
[ tolerance and effectiveness of oral erythromycin ethyl succinate , intravenous lactobionate and erythromycin base in infants and small children ] . | NA | {
"id": "C0014810",
"name": "erythromycin ethyl succinate",
"pos": [
38,
66
]
} | {
"id": "C0014806",
"name": "erythromycin base",
"pos": [
98,
115
]
} |
however , our isotope determinations suggest it will be impossible to resolve the problem as to whether the dinosaurs were warm-or cold-blooded from the oxygen and carbon isotopes content of their shells . | NA | {
"id": "C0022262",
"name": "isotope",
"pos": [
14,
21
]
} | {
"id": "C0007017",
"name": "carbon",
"pos": [
164,
170
]
} |
hybridization of radioactive nucleic acids with the dna of cytological preparations shows that the sequences of mouse satellite dna are located in the centromeric heterochromatin of the mouse chromosomes . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
52,
55
]
} | {
"id": "C0012934",
"name": "satellite dna",
"pos": [
118,
131
]
} |
[ effect of ee fatty acids ( ffa ) on free thyroxine fraction ( ft4f ) ( effects on thyroxine-binding protein ) ] . | NA | {
"id": "C0015684",
"name": "fatty acids",
"pos": [
15,
26
]
} | {
"id": "C0015688",
"name": "ffa",
"pos": [
29,
32
]
} |
[ the use of pyrimidine nucleosides ( cytidine and uridine ) in the therapy of cerebrl vascular disorders ] . | NA | {
"id": "C0034287",
"name": "pyrimidine nucleosides",
"pos": [
13,
35
]
} | {
"id": "C0010715",
"name": "cytidine",
"pos": [
38,
46
]
} |
[ the use of pyrimidine nucleosides ( cytidine and uridine ) in the therapy of cerebrl vascular disorders ] . | NA | {
"id": "C0034287",
"name": "pyrimidine nucleosides",
"pos": [
13,
35
]
} | {
"id": "C0041984",
"name": "uridine",
"pos": [
51,
58
]
} |
a diploid population of the polyploid amphibian odontophrynus americanus and an artificial intraspecific triploid hybrid . | NA | {
"id": "C0032578",
"name": "polyploid",
"pos": [
28,
37
]
} | {
"id": "C0333693",
"name": "triploid",
"pos": [
105,
113
]
} |
the prekallikrein obtained was functionally pure in that it had no kallikrein inhibiting or activating activity . | NA | {
"id": "C0033024",
"name": "prekallikrein",
"pos": [
4,
17
]
} | {
"id": "C0022478",
"name": "kallikrein",
"pos": [
67,
77
]
} |
d-amphetamine is markedly more potent an inhibitor of catecholamine uptake by norepinephrine neurons in the brain than is 1-amphetamine , whereas the two isomers are equally active in inhibiting catecholamine uptake by the dopamine neurons of the corpus striatum . | NA | {
"id": "C0011812",
"name": "d-amphetamine",
"pos": [
0,
13
]
} | {
"id": "C0002658",
"name": "amphetamine",
"pos": [
124,
135
]
} |
[ adrenocortical inhibition and urinary excretion of estriol , estrone and estradiol and of 17-ketosteroid fractions in full-term normal pregnancy ] . | NA | {
"id": "C0014942",
"name": "estrone",
"pos": [
63,
70
]
} | {
"id": "C0000167",
"name": "17-ketosteroid",
"pos": [
92,
106
]
} |
importance of sulphated acid muco-polysaccharides for fibrillogenesis in carrageenin granulomata of rats at different ages . | NA | {
"id": "C0032594",
"name": "polysaccharides",
"pos": [
34,
49
]
} | {
"id": "C0007289",
"name": "carrageenin",
"pos": [
73,
84
]
} |
a specific method for the estimation through a chromogen produced with concentrated hydrochloric acid of 11 beta-hydroxy-steroids of the pregnane series . | NA | {
"id": "C0038317",
"name": "steroids",
"pos": [
121,
129
]
} | {
"id": "C0033006",
"name": "pregnane",
"pos": [
137,
145
]
} |
hexosaminidase and percent hexosaminidase a ( hex a ) and other lysosomal enzymes were normal in cultured skin fibroblasts , liver , and brain . | NA | {
"id": "C0005270",
"name": "hexosaminidase",
"pos": [
0,
14
]
} | {
"id": "C0162330",
"name": "hexosaminidase a",
"pos": [
27,
43
]
} |
excluding specimen contamination , bacteriuria indicates either urinary colonization ( replication of bacteria in urine without evidence of tissue invasion ) or urinary tract infection ( bacteriuria associated with clinical , histologic , or immunologic evidence of host injury ) . | NA | {
"id": "C0042029",
"name": "urinary tract infection",
"pos": [
161,
184
]
} | {
"id": "C0004659",
"name": "bacteriuria",
"pos": [
187,
198
]
} |
although there are insufficient numbers of pretreatment scans to allow any conclusions , our data suggest that newer approaches to gallium scanning in treated patients are ( 1 ) highly specific in all lymphomas and most sensitive in high-grade non-hodgkin 's lymphoma and hodgkin 's disease ; | NA | {
"id": "C0024299",
"name": "lymphomas",
"pos": [
201,
210
]
} | {
"id": "C0024305",
"name": "non-hodgkin 's",
"pos": [
244,
258
]
} |
although there are insufficient numbers of pretreatment scans to allow any conclusions , our data suggest that newer approaches to gallium scanning in treated patients are ( 1 ) highly specific in all lymphomas and most sensitive in high-grade non-hodgkin 's lymphoma and hodgkin 's disease ; | NA | {
"id": "C0024299",
"name": "lymphomas",
"pos": [
201,
210
]
} | {
"id": "C0019829",
"name": "hodgkin 's disease",
"pos": [
272,
290
]
} |
after a meal consisting of fat , chylomicrons in which apolipoprotein b-48 was virtually the only apolipoprotein b present appeared in the urine , while apolipoprotein b-100 was the only apolipoprotein b present in the plasma very low-density lipoproteins . | NA | {
"id": "C0103839",
"name": "chylomicrons",
"pos": [
33,
45
]
} | {
"id": "C0003593",
"name": "apolipoprotein b",
"pos": [
187,
203
]
} |
after a meal consisting of fat , chylomicrons in which apolipoprotein b-48 was virtually the only apolipoprotein b present appeared in the urine , while apolipoprotein b-100 was the only apolipoprotein b present in the plasma very low-density lipoproteins . | NA | {
"id": "C0205666",
"name": "apolipoprotein b-100",
"pos": [
153,
173
]
} | {
"id": "C0003593",
"name": "apolipoprotein b",
"pos": [
187,
203
]
} |
because of the presence of chyluria , it was also demonstrated that chylomicrons in which apolipoprotein b-48 is virtually the only apolipoprotein b present are a physiologically normal product of the intestine . | NA | {
"id": "C0103839",
"name": "chylomicrons",
"pos": [
68,
80
]
} | {
"id": "C0003593",
"name": "apolipoprotein b",
"pos": [
132,
148
]
} |
the term retinoids has been used in recent years to include both natural and synthetic analogs of vitamin a . | NA | {
"id": "C0035339",
"name": "retinoids",
"pos": [
9,
18
]
} | {
"id": "C0042839",
"name": "vitamin a",
"pos": [
98,
107
]
} |
following a brief historical account of vitamin a and description of dietary information this article focuses on the chemistry and physiology of retinoids . | NA | {
"id": "C0042839",
"name": "a",
"pos": [
10,
11
]
} | {
"id": "C0035339",
"name": "retinoids",
"pos": [
145,
154
]
} |
the overall complication rate was 14.5 % and the most common complication was infection ( 13.3 % ) , in particular , endometritis ( 6.6 % ) , urinary tract infection ( 3.1 % ) , and wound infection ( 1.6 % ) . | NA | {
"id": "C0009450",
"name": "infection",
"pos": [
78,
87
]
} | {
"id": "C0042029",
"name": "urinary tract infection",
"pos": [
142,
165
]
} |
the overall complication rate was 14.5 % and the most common complication was infection ( 13.3 % ) , in particular , endometritis ( 6.6 % ) , urinary tract infection ( 3.1 % ) , and wound infection ( 1.6 % ) . | NA | {
"id": "C0009450",
"name": "infection",
"pos": [
78,
87
]
} | {
"id": "C0043241",
"name": "wound infection",
"pos": [
182,
197
]
} |
sodium restriction did not alter mean arterial pressure , but did increase plasma norepinephrine ( p less than 0.05 ) and epinephrine ( p less than 0.02 ) . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
82,
96
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
122,
133
]
} |
we conducted a clinicopathologic study of eight cases of angiolymphoid hyperplasia with eosinophilia ( kimura 's disease ) . | NA | {
"id": "C0002989",
"name": "angiolymphoid",
"pos": [
57,
70
]
} | {
"id": "C0014457",
"name": "eosinophilia",
"pos": [
88,
100
]
} |
six chordomas , nine chondrosarcomas , and three myxopapillary ependymomas of the filum terminale were evaluated immunohistochemically for the expression of intermediate filament proteins by the use of monospecific antibodies against intermediate filament proteins of keratin , vimentin , and glial fibrillary acidic protein ( gfap ) type . | NA | {
"id": "C0021769",
"name": "intermediate filament proteins",
"pos": [
157,
187
]
} | {
"id": "C0010803",
"name": "keratin",
"pos": [
268,
275
]
} |
six chordomas , nine chondrosarcomas , and three myxopapillary ependymomas of the filum terminale were evaluated immunohistochemically for the expression of intermediate filament proteins by the use of monospecific antibodies against intermediate filament proteins of keratin , vimentin , and glial fibrillary acidic protein ( gfap ) type . | NA | {
"id": "C0021769",
"name": "intermediate filament proteins",
"pos": [
157,
187
]
} | {
"id": "C0042666",
"name": "vimentin",
"pos": [
278,
286
]
} |
six chordomas , nine chondrosarcomas , and three myxopapillary ependymomas of the filum terminale were evaluated immunohistochemically for the expression of intermediate filament proteins by the use of monospecific antibodies against intermediate filament proteins of keratin , vimentin , and glial fibrillary acidic protein ( gfap ) type . | NA | {
"id": "C0021769",
"name": "intermediate filament proteins",
"pos": [
157,
187
]
} | {
"id": "C0017626",
"name": "glial fibrillary acidic",
"pos": [
293,
316
]
} |
to address this point , the authors carried out the following chemical modifications on soluble monomeric collagen and preformed fibrillar collagen in parallel : 1 ) n-and o-acetylation , 2 ) esterification of the carboxyl groups , 3 ) succinylation of the free amino groups , 4 ) esterification of succinylated collagen . | NA | {
"id": "C0969669",
"name": "fibrillar collagen",
"pos": [
129,
147
]
} | {
"id": "C0009325",
"name": "collagen",
"pos": [
312,
320
]
} |
neutralization of polar groups by 1 ) totally abolished aggregation and secretion by both collagens , while blocking acidic groups 2 ) resulted in enhanced aggregation and secretion by both soluble and fibrillar collagen . | NA | {
"id": "C0009325",
"name": "collagens",
"pos": [
90,
99
]
} | {
"id": "C0969669",
"name": "fibrillar collagen",
"pos": [
202,
220
]
} |
ordinarily , human material is obtained from cadavers at autopsy as soon as possible after death , and postmortem changes are evident . | NA | {
"id": "C0006629",
"name": "cadavers",
"pos": [
45,
53
]
} | {
"id": "C0011065",
"name": "death",
"pos": [
91,
96
]
} |
ordinarily , human material is obtained from cadavers at autopsy as soon as possible after death , and postmortem changes are evident . | NA | {
"id": "C0006629",
"name": "cadavers",
"pos": [
45,
53
]
} | {
"id": "C0032780",
"name": "postmortem changes",
"pos": [
103,
121
]
} |
in contrast , 1 mm alanine uptake was not modified by acidosis , greater intracellular metabolism lowering the cellular concentration of this amino acid . | NA | {
"id": "C0001898",
"name": "alanine",
"pos": [
19,
26
]
} | {
"id": "C0002520",
"name": "amino acid",
"pos": [
142,
152
]
} |
administration of hydrocortisone to normal fed rats increased renal net glucose release from 0.93 +/- 0.25 to 2.27 +/- 0.21 mg . dl-1 . min-1 and increased its contribution to blood glucose from 27.0 +/- 4.5 to 46.6 +/- 4.0 % . | NA | {
"id": "C0017725",
"name": "glucose",
"pos": [
72,
79
]
} | {
"id": "C0005802",
"name": "blood glucose",
"pos": [
176,
189
]
} |
the renal net glucose release and its contribution to blood glucose in adrenalectomized rats were 0.40 +/- 0.06 mg . dl-1 . min-1 and 16.3 +/- 1.4 % , respectively , significantly less than those of normal control rats , and these parameters were raised to the levels of normal control rats by the administration of hydrocortisone . | NA | {
"id": "C0017725",
"name": "glucose",
"pos": [
14,
21
]
} | {
"id": "C0005802",
"name": "blood glucose",
"pos": [
54,
67
]
} |
in rats with streptozotocin-induced diabetes , the renal net glucose release and its contribution to blood glucose were significantly increased to 2.22 +/- 0.51 mg . dl-1 . min-1 and 46.7 +/- 4.9 % , respectively , and these parameters were normalized by adrenalectomy . | NA | {
"id": "C0017725",
"name": "glucose",
"pos": [
61,
68
]
} | {
"id": "C0005802",
"name": "blood glucose",
"pos": [
101,
114
]
} |
these data indicate that glucocorticoids play an important role in regulation of renal net glucose release and its contribution to blood glucose in both normal and diabetic rats . | NA | {
"id": "C0017725",
"name": "glucose",
"pos": [
91,
98
]
} | {
"id": "C0005802",
"name": "blood glucose",
"pos": [
131,
144
]
} |
in contrast , a marked 26 % fall in absolute proximal chloride reabsorption occurred ( from 1,601 +/- 147 to 1,180 +/- 149 peq/min , p less than 0.005 ) , attributed to alteration in transcellular rather than passive sodium chloride transport . | NA | {
"id": "C0008203",
"name": "chloride",
"pos": [
54,
62
]
} | {
"id": "C0037494",
"name": "sodium chloride",
"pos": [
217,
232
]
} |
these results suggest that systemic ph affects a sodium chloride absorptive process and that the plasma bicarbonate concentration affects a chloride absorptive-bicarbonate secretory exchange process in the rat ileum . | NA | {
"id": "C0037494",
"name": "sodium chloride",
"pos": [
49,
64
]
} | {
"id": "C0008203",
"name": "chloride",
"pos": [
140,
148
]
} |
calculations also revealed that the contribution of glucose to overall atp production rose from 8 % in the absence of tolbutamide to about 30 % in the presence of the sulfonylurea . | NA | {
"id": "C0040374",
"name": "tolbutamide",
"pos": [
118,
129
]
} | {
"id": "C0038766",
"name": "sulfonylurea",
"pos": [
167,
179
]
} |
since in the stomach-empty and the stomach-distended conditions of each experiment the postpyloric compartments ( small intestine , portal , and systemic circulations ) were exposed to identical and physiological amounts of glucose , the difference in consumption must be ascribed to the distension of the stomach . | NA | {
"id": "C0038354",
"name": "the stomach",
"pos": [
9,
20
]
} | {
"id": "C0038353",
"name": "distension of",
"pos": [
288,
301
]
} |
the second method defines the prevalence of anemia as the proportion of women whose hemoglobin values are shifted downwards relative to a distribution of hemoglobin values of non-anemic women . | NA | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
84,
94
]
} | {
"id": "C0019016",
"name": "a",
"pos": [
179,
180
]
} |
the attachment and entry of plasmodium berghei sporozoites to cultured human lung fibroblast ( wi38 ) or hepatoma ( hepg2-a16 ) cells in vitro has been visualized using an immunoperoxidase technique coupled with light microscopy . | NA | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
82,
92
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
128,
133
]
} |
the data reported here are consistent with previously reported cae data , but suggest that isozyme analysis of leishmania isolates leading to identification should be based on data from many enzyme systems rather than just a few . | NA | {
"id": "C0022173",
"name": "isozyme",
"pos": [
91,
98
]
} | {
"id": "C0014442",
"name": "enzyme",
"pos": [
191,
197
]
} |
[ meniere 's vertigo . iv . statistical analysis of the use and effectiveness of drugs in the treatment of endolymphatic hydrops ] . | NA | {
"id": "C0025281",
"name": "meniere 's vertigo",
"pos": [
2,
20
]
} | {
"id": "C0206586",
"name": "endolymphatic hydrops",
"pos": [
107,
128
]
} |
[ biotransformation of fentanyl . iii . effect of chronic drug exposure on the distribution , metabolism and excretion in the rat ] . | NA | {
"id": "C0025519",
"name": "metabolism",
"pos": [
94,
104
]
} | {
"id": "C0221102",
"name": "excretion",
"pos": [
109,
118
]
} |
cryostat sections from the mesonephros of various pig embryos with a crown-rump-length of between 17 and 95 mm were used for light microscopical assays of acid hydrolases ( acid phosphatase , beta-d-n-acetylglucosaminidase , beta-d-glucuronidase ) , oxidoreductases ( succinic dehydrogenase , nadh- and nadph-tetrazolium reductase ) and adenosine triphosphatases ( mg2+- and na+ -- k+-atpase ) . | NA | {
"id": "C0001473",
"name": "adenosine triphosphatases",
"pos": [
337,
362
]
} | {
"id": "C0001479",
"name": "na",
"pos": [
375,
377
]
} |
organic extracts with methanol , ethanol , chloroform , ethyl acetate , and benzene were ineffective in removing the toxin from the seeds . | NA | {
"id": "C0001963",
"name": "methanol",
"pos": [
22,
30
]
} | {
"id": "C0001962",
"name": "ethanol",
"pos": [
33,
40
]
} |
the ec50 values in milligrams of sulfate per cubic meter for cupric sulfate , zinc sulfate , ferric sulfate , and zinc ammonium sulfate were 2.7 , 4.5 , 7.5 , and 17.9 , respectively . | NA | {
"id": "C0038720",
"name": "sulfate",
"pos": [
33,
40
]
} | {
"id": "C0056301",
"name": "cupric sulfate",
"pos": [
61,
75
]
} |
the ec50 values in milligrams of sulfate per cubic meter for cupric sulfate , zinc sulfate , ferric sulfate , and zinc ammonium sulfate were 2.7 , 4.5 , 7.5 , and 17.9 , respectively . | NA | {
"id": "C0038720",
"name": "sulfate",
"pos": [
33,
40
]
} | {
"id": "C0078794",
"name": "zinc",
"pos": [
114,
118
]
} |
common respiratory infections occurring in a wide range of mammals are summarized , and procedures for detection of spontaneous infectious diseases affecting experimental studies are described . | NA | {
"id": "C0035243",
"name": "respiratory",
"pos": [
7,
18
]
} | {
"id": "C0009450",
"name": "infectious diseases",
"pos": [
128,
147
]
} |
cardiac anomalies which predispose to this type of compression include ventricular septal defect , patent ductus arteriosus , interruption of the aortic arch , and tetralogy of fallot . | NA | {
"id": "C0018798",
"name": "cardiac",
"pos": [
0,
7
]
} | {
"id": "C0013274",
"name": "patent ductus arteriosus",
"pos": [
99,
123
]
} |
cardiac anomalies which predispose to this type of compression include ventricular septal defect , patent ductus arteriosus , interruption of the aortic arch , and tetralogy of fallot . | NA | {
"id": "C0018798",
"name": "cardiac",
"pos": [
0,
7
]
} | {
"id": "C0039685",
"name": "tetralogy of fallot",
"pos": [
164,
183
]
} |
birth weight , placental weight and gestation time of 26258 single births at ramathibodi hospital during 1973-7 were studied in relation to natural selection by fitting quadratic function to natural log of survivors-to-nonsurvivors ratios . | NA | {
"id": "C0005612",
"name": "birth weight",
"pos": [
0,
12
]
} | {
"id": "C0005910",
"name": "weight",
"pos": [
25,
31
]
} |
the estimated optimal values of birth weight and placental weight were 0.62 and 0.90 standard deviations , respectively , above the corresponding arithmetic means . | NA | {
"id": "C0005612",
"name": "birth weight",
"pos": [
32,
44
]
} | {
"id": "C0005910",
"name": "weight",
"pos": [
59,
65
]
} |
selection on birth weight and placental weight was asymmetrical about the optima , being more intense among the lower than the higher values . | NA | {
"id": "C0005612",
"name": "birth weight",
"pos": [
13,
25
]
} | {
"id": "C0005910",
"name": "weight",
"pos": [
40,
46
]
} |
na+- and k+-dependent adenosine triphosphatase [ ( na+ + k+ ) -atpase ] was studied in microdissected samples from sections of histologically active and inactive plaques of multiple sclerosis . | NA | {
"id": "C0001473",
"name": "adenosine triphosphatase",
"pos": [
22,
46
]
} | {
"id": "C0001479",
"name": "na",
"pos": [
154,
156
]
} |
combined use of benzylpenicillin or ampicillin with sulfalen or sulfadimethoxine resulted in a decreased binding of the antibiotics to the blood serum proteins and slower elimination of penicillins from the experimental rabbits . | NA | {
"id": "C0030827",
"name": "benzylpenicillin",
"pos": [
16,
32
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
36,
46
]
} |
[ comparative clinical efficacy of cephotaxim and cefuroxime against the pathogens of inflammation in obstetrics and gynecology ] . | NA | {
"id": "C0007554",
"name": "cephotaxim",
"pos": [
35,
45
]
} | {
"id": "C0007562",
"name": "cefuroxime",
"pos": [
50,
60
]
} |
the isolates did not reduce sulfate , sulfur , thiosulfate , or nitrate and were independent of growth factors . | NA | {
"id": "C0038720",
"name": "sulfate",
"pos": [
28,
35
]
} | {
"id": "C0039950",
"name": "thiosulfate",
"pos": [
47,
58
]
} |
a mycotoxin , ( e ) -ascladiol , was established as a direct precursor of patulin in cell-free preparations of penicillium urticae patulin-minus mutants j1 and s11 , but not s15 . | NA | {
"id": "C0026955",
"name": "mycotoxin",
"pos": [
2,
11
]
} | {
"id": "C0030710",
"name": "patulin",
"pos": [
131,
138
]
} |
the patients consisted of 12 acute myelocytic leukemias , 4 acute monocytic leukemias , 2 acute lymphocytic leukemias , one erythroleukemia , one malignant lymphoma and one chronic monocytic leukemia . | NA | {
"id": "C0023467",
"name": "acute myelocytic leukemias",
"pos": [
29,
55
]
} | {
"id": "C0023465",
"name": "acute monocytic leukemias",
"pos": [
60,
85
]
} |
anticancer agents , mitomycin c and adriamycin , were immobilized on absorbable gelatin materials , respectively with a blood clotting factor , factor xiii and thrombin with a special technique we have developed . | NA | {
"id": "C0005789",
"name": "blood clotting factor",
"pos": [
120,
141
]
} | {
"id": "C0015528",
"name": "factor xiii",
"pos": [
144,
155
]
} |
anticancer agents , mitomycin c and adriamycin , were immobilized on absorbable gelatin materials , respectively with a blood clotting factor , factor xiii and thrombin with a special technique we have developed . | NA | {
"id": "C0005789",
"name": "blood clotting factor",
"pos": [
120,
141
]
} | {
"id": "C0040018",
"name": "thrombin",
"pos": [
160,
168
]
} |
administration condition of lnt for gastrointestinal cancer was designed as the following : lnt was administered intravenously at doses of 1 mg/person/day twice a week or 2 mg/person/day once a week in combination with mitomycine c + 5-fu ( mf ) or tegafur ( ft ) . | NA | {
"id": "C0016360",
"name": "fu",
"pos": [
236,
238
]
} | {
"id": "C0016778",
"name": "tegafur",
"pos": [
249,
256
]
} |
cea , nfa-2 and nca-2 were very similar to each other physiochemically and antigenically , but cea-distinctive and nfa-2-distinctive determinants were detected by using specifically prepared antisera . | NA | {
"id": "C0003320",
"name": "nfa",
"pos": [
6,
9
]
} | {
"id": "C0003316",
"name": "nfa",
"pos": [
115,
118
]
} |
from these results , it was concluded that cea and nfa-2 could be divided into four antigenic moieties , that is , nca-common , nfca-common , nfa-1-common determinant and cea-distinctive or nfa-2-distinctive determinant . | NA | {
"id": "C0003320",
"name": "antigenic",
"pos": [
84,
93
]
} | {
"id": "C0003316",
"name": "nfa",
"pos": [
190,
193
]
} |
73 percent of 199 non hodgkins ' lymphomas were of t-cell origin , and 58 percent of these t-cell lymphomas were atl in nagasaki , japan . | NA | {
"id": "C0024305",
"name": "non hodgkins",
"pos": [
18,
30
]
} | {
"id": "C0079772",
"name": "t-cell lymphomas",
"pos": [
91,
107
]
} |
seven patients had had irradiation and also had v-p shunt operation for hydrocephalus 5-fu concentration in csf was extremely high in fd-1 and tac-278 administration , but not in tegafur and hcfu administration . | NA | {
"id": "C0016360",
"name": "fu",
"pos": [
88,
90
]
} | {
"id": "C0016778",
"name": "tegafur",
"pos": [
179,
186
]
} |
in addition , tegafur and hcfu did not reveal any cumulative effects of 5-fu in csf by continuous prolonged systemic administration . | NA | {
"id": "C0016778",
"name": "tegafur",
"pos": [
14,
21
]
} | {
"id": "C0016360",
"name": "fu",
"pos": [
74,
76
]
} |
the patients were administrated tegafur preoperatively and tissue samples were obtained intraoperatively , 5-fu levels in tumor and lymph node were measured by gcmf . | NA | {
"id": "C0016778",
"name": "tegafur",
"pos": [
32,
39
]
} | {
"id": "C0016360",
"name": "fu",
"pos": [
109,
111
]
} |
the patients , being measured 5-fu uptake by tissue and received tegafur over 60 g as postoperative adjuvant chemotherapy , were divided into two groups ; | NA | {
"id": "C0016360",
"name": "5-fu",
"pos": [
30,
34
]
} | {
"id": "C0016778",
"name": "tegafur",
"pos": [
65,
72
]
} |
levels of futraful ( ft-207 ) , 5-fu and uracil in blood and tissue were measured on 11 cases of oral malignant tumors after administration of uft . | NA | {
"id": "C0016360",
"name": "5-fu",
"pos": [
32,
36
]
} | {
"id": "C0041917",
"name": "uracil",
"pos": [
41,
47
]
} |
3 ) there were significant regressions in levels of 5-fu and uracil in normal lymph node ( p less than 0.02 ) . | NA | {
"id": "C0016360",
"name": "fu",
"pos": [
54,
56
]
} | {
"id": "C0041917",
"name": "uracil",
"pos": [
61,
67
]
} |
faster recovery of granulopoiesis was observed by pretreating recipients with rbc hypertransfusion and/or ok-432 ( picibanil , biological products of beta-streptococci . ) | NA | {
"id": "C0031875",
"name": "picibanil",
"pos": [
115,
124
]
} | {
"id": "C0005522",
"name": "biological products",
"pos": [
127,
146
]
} |
two patients with rheumatoid arthritis without splenomegaly or felty 's syndrome developed spontaneous rupture of the spleen . | NA | {
"id": "C0003873",
"name": "rheumatoid arthritis",
"pos": [
18,
38
]
} | {
"id": "C0015773",
"name": "felty 's syndrome",
"pos": [
63,
80
]
} |
the order of activity of some standard 5-nitroimidazoles obtained on the basis of several mouse or hamster infections with trichomonads and e. histolytica , respectively , was : fexinidazole greater than tinidazole and ornidazole greater than metronidazole greater than nitrimidazine ( nimorazole ) , except that ornidazole had an amoebicidal effect close to that of fexinidazole . | NA | {
"id": "C0028179",
"name": "nitroimidazoles",
"pos": [
41,
56
]
} | {
"id": "C0025872",
"name": "metronidazole",
"pos": [
243,
256
]
} |
the order of activity of some standard 5-nitroimidazoles obtained on the basis of several mouse or hamster infections with trichomonads and e. histolytica , respectively , was : fexinidazole greater than tinidazole and ornidazole greater than metronidazole greater than nitrimidazine ( nimorazole ) , except that ornidazole had an amoebicidal effect close to that of fexinidazole . | NA | {
"id": "C0028179",
"name": "nitroimidazoles",
"pos": [
41,
56
]
} | {
"id": "C0028095",
"name": "nimorazole",
"pos": [
286,
296
]
} |
the order of activity of some standard 5-nitroimidazoles obtained on the basis of several mouse or hamster infections with trichomonads and e. histolytica , respectively , was : fexinidazole greater than tinidazole and ornidazole greater than metronidazole greater than nitrimidazine ( nimorazole ) , except that ornidazole had an amoebicidal effect close to that of fexinidazole . | NA | {
"id": "C0028179",
"name": "nitroimidazoles",
"pos": [
41,
56
]
} | {
"id": "C0029274",
"name": "ornidazole",
"pos": [
313,
323
]
} |
the proportion of infected fibroblasts decreased in both the control and the irradiated cells , indicating that dilution of the parasites by cell multiplication was not the main factor in the observed decrease of the infection with time . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
27,
38
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
88,
93
]
} |
in these studies , total cell associated radioactivity as well as the total and tca precipitable radioactivity of the culture medium were similar for infected and non-infected fibroblasts during the course of infection . | NA | {
"id": "C0007634",
"name": "cell",
"pos": [
25,
29
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
176,
187
]
} |
human chorionic gonadotropin was detected in semen only after injection . beta-human chorionic gonadotropin in the semen represents a degradation product of circulating lh . | NA | {
"id": "C0018062",
"name": "human chorionic",
"pos": [
0,
15
]
} | {
"id": "C0106132",
"name": "beta-human chorionic",
"pos": [
74,
94
]
} |
1 tricuspid hypoplasia , 1 absent left pulmonary artery , 1 mitral valve prolapse , 1 obstructive cardiomyopathy , 10 coronary anomalies ( including 5 ectopic left anterior descending arteries arising from the right coronary artery ) , 8 patent ductus arteriosus ( arising from the left subclavian in 4 cases of right aortic arch ) , 3 retro oesophageal subclavian arteries and one congenital subclavian steal syndrome . | NA | {
"id": "C0018798",
"name": "coronary anomalies",
"pos": [
118,
136
]
} | {
"id": "C0013274",
"name": "patent ductus arteriosus",
"pos": [
238,
262
]
} |
we investigated the kinetics of the antral g cells in the hamster , g cells and s cells in the rat duodenum by the combined utilization of 3h-thymidine autoradiography with immunohistochemistry , and confirmed that these cells are derived from the same precursor cells as the other mucosal cells of the gastrointestinal tract . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
45,
50
]
} | {
"id": "C0018956",
"name": "precursor cells",
"pos": [
253,
268
]
} |
npnl have fine autoregulation mechanisms among which of special importance is the synthesis of biologically active substances : leukotrienes , including a slow acting anaphylaxis substance , prostaglandins , and prostacyclins . | NA | {
"id": "C0033554",
"name": "prostaglandins",
"pos": [
191,
205
]
} | {
"id": "C0205911",
"name": "prostacyclins",
"pos": [
212,
225
]
} |
group ii received mit 200 , as did group iv in which the sucrose was replaced by sugars in the same proportions as in dried apple . | NA | {
"id": "C0038636",
"name": "sucrose",
"pos": [
57,
64
]
} | {
"id": "C0242209",
"name": "sugars",
"pos": [
81,
87
]
} |
when compared with normal persons , those with optic nerve disease ( multiple sclerosis , optic neuritis , and optic atrophy ) showed an overall weakness for all colors ( enlarged neutral areas ) , with an additional specific defect in the orange-cyan ( greenish blue ) axis . | NA | {
"id": "C0029132",
"name": "optic nerve disease",
"pos": [
47,
66
]
} | {
"id": "C0029134",
"name": "optic neuritis",
"pos": [
90,
104
]
} |
when compared with normal persons , those with optic nerve disease ( multiple sclerosis , optic neuritis , and optic atrophy ) showed an overall weakness for all colors ( enlarged neutral areas ) , with an additional specific defect in the orange-cyan ( greenish blue ) axis . | NA | {
"id": "C0029132",
"name": "optic nerve disease",
"pos": [
47,
66
]
} | {
"id": "C0029124",
"name": "optic atrophy",
"pos": [
111,
124
]
} |
the effect of kanamycin on the cochlear sensory epithelium of albino guinea pig fetuses was studied histologically following the administration of 200 or 400 mg/kg body weight kanamycin sulfate to the pregnant mothers for 8 consecutive days at different stages of gestation . | NA | {
"id": "C0022487",
"name": "kanamycin",
"pos": [
14,
23
]
} | {
"id": "C0700540",
"name": "kanamycin sulfate",
"pos": [
176,
193
]
} |
these changes resulted in both a higher high density lipoprotein cholesterol/total cholesterol ratio ( p = 0.01 ) and a higher high density lipoprotein cholesterol/low density cholesterol ratio ( p = 0.02 ) in the insulin-infused group . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
65,
76
]
} | {
"id": "C0023822",
"name": "higher",
"pos": [
120,
126
]
} |
the functional neuroses and psychoses and the organic psychiatric diseases , together with personality and psychomatic disorders and drug dependence , are reviewed . | NA | {
"id": "C0004936",
"name": "psychoses",
"pos": [
28,
37
]
} | {
"id": "C0029227",
"name": "organic psychiatric diseases",
"pos": [
46,
74
]
} |
the purpose of this study was to investigate the relationship between hypoxia and heart rate ( hr ) , pulmonary ventilation , plasma epinephrine ( e ) and norepinephrine ( ne ) at rest and during exercise at 40 % of maximal oxygen uptake . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
133,
144
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
155,
169
]
} |
furthermore , the cathepsin-modified and native forms of aldolase were both resistant to extensive proteolysis by other purified cellular proteinases and lysosomal extracts at ph values of 4.8-8.0 . | NA | {
"id": "C0007428",
"name": "cathepsin",
"pos": [
18,
27
]
} | {
"id": "C0030940",
"name": "proteinases",
"pos": [
138,
149
]
} |
two non-identical subunits were isolated from the foetal intestinal isoenzyme , one having same molecular weight and isoelectric point as placental alkaline phosphatase , and the other corresponding to a glycosylated subunit of the adult intestinal enzyme . | NA | {
"id": "C0022173",
"name": "isoenzyme",
"pos": [
68,
77
]
} | {
"id": "C0014442",
"name": "enzyme",
"pos": [
249,
255
]
} |
the enzyme also degraded a series of dipeptides , alanine oligopeptides and some naturally occurring peptides . | NA | {
"id": "C0012512",
"name": "dipeptides",
"pos": [
37,
47
]
} | {
"id": "C0028954",
"name": "oligopeptides",
"pos": [
58,
71
]
} |
the enzyme also degraded a series of dipeptides , alanine oligopeptides and some naturally occurring peptides . | NA | {
"id": "C0028954",
"name": "oligopeptides",
"pos": [
58,
71
]
} | {
"id": "C0030956",
"name": "peptides",
"pos": [
101,
109
]
} |
hence , the alterations in glycan structure detected in bulk cellular glycoproteins of ricr cells are expressed also in cell surface glycoproteins and in fibronectin , a secreted glycoprotein . | NA | {
"id": "C0025248",
"name": "cell surface glycoproteins",
"pos": [
120,
146
]
} | {
"id": "C0017968",
"name": "glycoprotein",
"pos": [
179,
191
]
} |
the tendency of melittin to aggregate is dependent on the counter-anions present in solution , the effect being most marked with phosphate , decreasing in the order hpo4 ( 2- ) greater than so4 ( 2- ) greater than clo4- greater than cl- . | NA | {
"id": "C0003075",
"name": "anions",
"pos": [
66,
72
]
} | {
"id": "C0031603",
"name": "phosphate",
"pos": [
129,
138
]
} |
four peptidases , namely endopeptidase ( ec 3.4.24.11 ) , aminopeptidases n ( ec 3.4.11.2 ) and a ( ec 3.4.11.7 ) and dipeptidyl peptidase iv ( ec 3.4.14.5 ) , were shown to be reconstituted . | NA | {
"id": "C0030940",
"name": "peptidases",
"pos": [
5,
15
]
} | {
"id": "C0030946",
"name": "endopeptidase",
"pos": [
25,
38
]
} |
the present results indicate that the lactoferrin-clearance pathway is distinct from several pathways mediating glycoprotein clearance through recognition of terminal galactose , fucose , n-acetylglucosamine or mannose . | NA | {
"id": "C0022942",
"name": "lactoferrin",
"pos": [
38,
49
]
} | {
"id": "C0017968",
"name": "glycoprotein",
"pos": [
112,
124
]
} |
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