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the cells actively incorporated 14c ( 1 ) -labeled free fatty acids into glycerolipids [ ( 1-14c ] acetate was utilized for both fatty acid and cholesterol synthesis ) , while [ 14c ( u ) ] glucose label was found in cholesterol and in the glycerol moiety of glycerolipids , but not in fatty acids . | NA | {
"id": "C0015688",
"name": "free fatty acids",
"pos": [
51,
67
]
} | {
"id": "C0015684",
"name": "fatty acids",
"pos": [
286,
297
]
} |
no significant increase was detected in the serum ck-bb ( ck-1 ) or ck-mb ( ck-2 ) activity whereas a pronounced elevation of the ck-mm ( ck-3 ) activity was found , particularly in the stress-sensitive animals . | NA | {
"id": "C0010291",
"name": "ck-mm",
"pos": [
130,
135
]
} | {
"id": "C0010287",
"name": "ck",
"pos": [
138,
140
]
} |
pargyline , a monoamine oxidase inhibitor , led to a marked increase in serotonin and a decrease of 5-hydroxyindoleacetic acid while p-chlorophenylalanine , by blocking the conversion of tryptophan to 5-hydroxytryptophan , selectively depleted 5-hydroxytryptophan , serotonin , and 5-hydroxyindoleacetic acid . | NA | {
"id": "C0041249",
"name": "tryptophan",
"pos": [
187,
197
]
} | {
"id": "C0000578",
"name": "5-hydroxytryptophan",
"pos": [
244,
263
]
} |
coproporphyrin was the major porphyrin to accumulate in response to allylisopropylacetamide , aromatic amides , and steroids , a result suggesting inhibition of coproporphyrinogen oxidase . | NA | {
"id": "C0009988",
"name": "coproporphyrin",
"pos": [
0,
14
]
} | {
"id": "C0032712",
"name": "porphyrin",
"pos": [
166,
175
]
} |
however , this difference was less for noradrenaline and adrenaline which were therefore tension selective relative to isoproterenol . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
39,
52
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
57,
67
]
} |
the efficacies ( er ) of noradrenaline and adrenaline were greater than isoproterenol for tension , but smaller for rate responses , which may explain their relative tension selectivity . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
25,
38
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
43,
53
]
} |
the crude extracellular enzyme readily hydrolyzed acid-swollen cellulose with the production of glucose and cellobiose . | NA | {
"id": "C0007648",
"name": "cellulose",
"pos": [
63,
72
]
} | {
"id": "C0007630",
"name": "cellobiose",
"pos": [
108,
118
]
} |
on the other hand , the location of the tumor showed a significant relation to gastritis : the progression of gastritis was more rapid ( high mean aas value ) and the prevalence of atrophic gastritis was higher in the tumor-affected area ( i.e. , in the antrum in patients with antral [ distal ] tumors ; in the body in patients with body [ proximal ] tumors ) , than in the general population , but were similar in the tumor-free area in both gc patients and controls . | NA | {
"id": "C0017152",
"name": "gastritis",
"pos": [
79,
88
]
} | {
"id": "C0017154",
"name": "atrophic gastritis",
"pos": [
181,
199
]
} |
the results suggest that tumor histologic type is not a useful prognostic indicator in small cell carcinoma , and that atypical tumors resembling small cell carcinoma appear to respond similarly to classical small cell carcinoma and should probably be treated as such . | NA | {
"id": "C0027652",
"name": "tumor",
"pos": [
25,
30
]
} | {
"id": "C0027651",
"name": "tumors",
"pos": [
128,
134
]
} |
the sensitivity of membrane immunofluorescence assays for the antigen was increased by using a mixture of antibodies to several epitopes of p97 . | NA | {
"id": "C0003320",
"name": "antigen",
"pos": [
62,
69
]
} | {
"id": "C0003316",
"name": "epitopes",
"pos": [
128,
136
]
} |
the study also demonstrated that a modified histologic classification of anaplastic astrocytoma versus glioblastoma provided better prognostic information than the astrocytoma grading system of kernohan . | NA | {
"id": "C0017636",
"name": "glioblastoma",
"pos": [
103,
115
]
} | {
"id": "C0004114",
"name": "astrocytoma",
"pos": [
164,
175
]
} |
in 13 npc patients , the carcinoma had invaded cervical lymph nodes , and their sera revealed , in addition to high igg anti-vca titers , elevated levels of iga antibodies to vca , of igg antibodies to d , and most also had iga anti-d . | NA | {
"id": "C0003320",
"name": "vca",
"pos": [
125,
128
]
} | {
"id": "C0003342",
"name": "vca",
"pos": [
175,
178
]
} |
the cytosol from chick liver and brain contains specific high affinity binding sites for the phorbol ester 12-o-tetradecanoyl-phorbol-13-acetate ( tpa ) . | NA | {
"id": "C0031586",
"name": "phorbol ester",
"pos": [
93,
106
]
} | {
"id": "C0039654",
"name": "phorbol",
"pos": [
126,
133
]
} |
nitrosodi-n-propylamine , nitrosodi-n-butylamine and the ketone nitrosobis ( 2-oxopropyl ) amine were administered by gavage to f344 rats at doses of 1 and 2 mmol for 30 weeks . | NA | {
"id": "C0033504",
"name": "propylamine",
"pos": [
12,
23
]
} | {
"id": "C0002508",
"name": "amine",
"pos": [
91,
96
]
} |
membrane glycoprotein synthesis was studied in non-tumorigenic and tumor cells treated with the lymphokine hormone , lymphotoxin , to define the biochemical mechanisms by which lymphotoxin prevents carcinogenesis and inhibits growth of tumor cells . | NA | {
"id": "C0024297",
"name": "lymphokine",
"pos": [
96,
106
]
} | {
"id": "C0024320",
"name": "lymphotoxin",
"pos": [
177,
188
]
} |
superoxide formation by nadh dehydrogenase after anthracycline treatment appeared to follow saturation kinetics with an apparent km of 167.3 , 73.3 , 64.0 , or 47.6 microm for doxorubicin , daunorubicin , rubidazone , or aclacinomycin a , respectively . | NA | {
"id": "C0013089",
"name": "doxorubicin",
"pos": [
176,
187
]
} | {
"id": "C0011015",
"name": "daunorubicin",
"pos": [
190,
202
]
} |
superoxide formation by nadh dehydrogenase after doxorubicin treatment occurred with a ph optimum of 7.6 and was accompanied by the production of hydrogen peroxide . | NA | {
"id": "C0038836",
"name": "superoxide",
"pos": [
0,
10
]
} | {
"id": "C0031180",
"name": "peroxide",
"pos": [
155,
163
]
} |
calcium and magnesium acetates were administered as 3 % dietary supplements for 2 weeks prior to and 2 weeks after the cdcl2 injection , or as three daily s.c. injections ( 0.16 mmol calcium acetate per kg , 4 mmol magnesium acetate per kg ; 0.9 % nacl solutions ) at the same site as cdcl2 on the day before , the day of , and the day after cdcl2 dosing . | NA | {
"id": "C0006675",
"name": "calcium",
"pos": [
0,
7
]
} | {
"id": "C0717537",
"name": "calcium acetate",
"pos": [
183,
198
]
} |
monoclonal antibodies were produced against mm46 , an mm antigen-positive , ascitic mouse mammary tumor of c3h/he mice , and 14 clones were found to produce antibodies reactive with mm46 , but not with an mm antigen-negative mm48 tumor . | NA | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
0,
21
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
157,
167
]
} |
the immunoglobulin class of eight antibodies detecting the same antigenic determinant on mm1 was examined and was found to cover major classes of mouse immunoglobulin ( mu , gamma 1 , gamma 2a , gamma 2b , gamma 3 , and alpha ) . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
34,
44
]
} | {
"id": "C0021017",
"name": "classes",
"pos": [
135,
142
]
} |
phosphorylation of ara-a , adenosine , and tubercidin , but not deoxyadenosine or deoxycytidine , was greatly reduced in intact l1210/ara-a cells , relative to l1210/c2 cells , and adenosine kinase activity in extracts of l1210/ara-a cells was negligible . | NA | {
"id": "C0001443",
"name": "adenosine",
"pos": [
27,
36
]
} | {
"id": "C0042646",
"name": "ara-a",
"pos": [
228,
233
]
} |
the results show that while tumors of the same histological type had similar 5-methylcytosine values , discrepancies existed between values obtained for fresh tumors and their corresponding cell lines . | NA | {
"id": "C0027652",
"name": "tumors of",
"pos": [
28,
37
]
} | {
"id": "C0027651",
"name": "tumors",
"pos": [
159,
165
]
} |
in the present study , these fibroblasts were completely removed by incubating the cells with antiserum raised against nude mouse spleen cells . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
29,
40
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
137,
142
]
} |
this receptor modulating potency of dihydroteleocidin b , was 10 times that of a phorbol ester tumor promoter 12-o-tetradecanoylphorbol-13-acetate ( tpa ) . | NA | {
"id": "C0031586",
"name": "phorbol ester",
"pos": [
81,
94
]
} | {
"id": "C0039654",
"name": "12-o-tetradecanoylphorbol-13-acetate",
"pos": [
110,
146
]
} |
short-term cultures of tumor cells , used to confirm that tumors had dna content indistinguishable from diploid , demonstrated a single near-diploid peak on repeat dna analysis with or without the addition of diploid lymphocytes and internal dna standards . | NA | {
"id": "C0000702",
"name": "a",
"pos": [
55,
56
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
242,
245
]
} |
gallium nitrate was evaluated by the southwest oncology group in 38 patients with malignant lymphoma , both hodgkin 's disease and non-hodgkin 's lymphoma . | NA | {
"id": "C0024299",
"name": "malignant lymphoma",
"pos": [
82,
100
]
} | {
"id": "C0019829",
"name": "hodgkin 's disease",
"pos": [
108,
126
]
} |
gallium nitrate was evaluated by the southwest oncology group in 38 patients with malignant lymphoma , both hodgkin 's disease and non-hodgkin 's lymphoma . | NA | {
"id": "C0024299",
"name": "malignant lymphoma",
"pos": [
82,
100
]
} | {
"id": "C0024305",
"name": "non-hodgkin 's lymphoma",
"pos": [
131,
154
]
} |
histologic diagnoses were glioblastoma ( eight patients ) , medulloblastoma ( one ) , ependymoma ( one ) , ependymoblastoma ( one ) , pontine glioma ( one ) , and astrocytoma ( one ) . | NA | {
"id": "C0017636",
"name": "glioblastoma",
"pos": [
26,
38
]
} | {
"id": "C0004114",
"name": "astrocytoma",
"pos": [
163,
174
]
} |
histologic diagnoses were glioblastoma ( eight patients ) , medulloblastoma ( one ) , ependymoma ( one ) , ependymoblastoma ( one ) , pontine glioma ( one ) , and astrocytoma ( one ) . | NA | {
"id": "C0025149",
"name": "medulloblastoma",
"pos": [
60,
75
]
} | {
"id": "C0017638",
"name": "glioma",
"pos": [
142,
148
]
} |
histologic diagnoses were glioblastoma ( eight patients ) , medulloblastoma ( one ) , ependymoma ( one ) , ependymoblastoma ( one ) , pontine glioma ( one ) , and astrocytoma ( one ) . | NA | {
"id": "C0014474",
"name": "ependymoma",
"pos": [
86,
96
]
} | {
"id": "C0017638",
"name": "glioma",
"pos": [
142,
148
]
} |
a new method for covalent coupling of heparin and other glycosaminoglycans to substances containing primary amino groups . | NA | {
"id": "C0019134",
"name": "heparin",
"pos": [
38,
45
]
} | {
"id": "C0017973",
"name": "glycosaminoglycans",
"pos": [
56,
74
]
} |
the immunoperoxidase technique was applied on the following kind of tissues : normal parotid glands , morbus sjogren , cystadenolymphomas , pleomorphic adenomas , adenocarcinomas , adenoid cystic carcinomas , salivary duct carcinomas , mucoepidermoid tumors , squamous cell carcinomas , and anaplastic carcinomas . | NA | {
"id": "C0001418",
"name": "adenocarcinomas",
"pos": [
163,
178
]
} | {
"id": "C0010606",
"name": "adenoid",
"pos": [
181,
188
]
} |
in addition , antiserum against neuron-specific enolase ( nse ) was applied to these tumors , in order to demonstrate their neuroendocrine nature , alpha-hcg-immunoreactive cells were present in 42/56 ( 75 % ) functioning malignant pancreatic endocrine tumors , but in only 1 , possibly benign , glucagonoma out of 67 functioning benign tumors , in only 1/17 nonfunctioning malignant , and in 0/17 nonfunctioning benign tumors . | NA | {
"id": "C1328479",
"name": "malignant",
"pos": [
222,
231
]
} | {
"id": "C0017689",
"name": "glucagonoma",
"pos": [
296,
307
]
} |
the four antigens ( adeno taa and taa epitope , squamous taa and taa epitope ) did not react in vcs-tli with coded sera from preselected normal individuals with known medical histories . | NA | {
"id": "C0003320",
"name": "antigens",
"pos": [
9,
17
]
} | {
"id": "C0003316",
"name": "epitope",
"pos": [
69,
76
]
} |
cross-reacting ( with other non-lung cancers ) and specific peptide sequences of taa were indicated in the comparative tests with the corresponding taa epitopes , suggesting the tests for probing and analyzing portions of the antigens . | NA | {
"id": "C0003316",
"name": "epitopes",
"pos": [
152,
160
]
} | {
"id": "C0003320",
"name": "antigens",
"pos": [
226,
234
]
} |
opiate drugs and peptides inhibited the dopamine binding in the presence of both gtp and gpp ( nh ) p . | NA | {
"id": "C0018353",
"name": "gtp",
"pos": [
81,
84
]
} | {
"id": "C0018366",
"name": "gpp ( nh ) p",
"pos": [
89,
101
]
} |
epidermal keratinocyte growth in the higher dose of 20 mm alpha-dfmo , however , did not decrease the cellular levels of putrescine . | NA | {
"id": "C0022567",
"name": "growth",
"pos": [
23,
29
]
} | {
"id": "C0007634",
"name": "cellular",
"pos": [
102,
110
]
} |
polyamine analyses of the spent medium showed that growth in 10 mm alpha-dfmo decreased the normal epidermal cell transport of putrescine and spermidine into the medium . | NA | {
"id": "C0034170",
"name": "putrescine",
"pos": [
127,
137
]
} | {
"id": "C0037871",
"name": "medium",
"pos": [
162,
168
]
} |
thyroid-stimulating hormone , the catecholamine isoproterenol , and prostaglandins e1 and e2 , all substances known to increase camp concentration in thyroid tissue , accelerate the formation of follicular cavities in explanted thyroid of 15-day-old rat foetuses . | NA | {
"id": "C0007412",
"name": "catecholamine",
"pos": [
34,
47
]
} | {
"id": "C0022245",
"name": "isoproterenol",
"pos": [
48,
61
]
} |
furthermore , unlike the other mabs , the prevalence of hemocytes staining with iid7.1-bg antibodies differed between two strains of b. glabrata . | NA | {
"id": "C0003250",
"name": "mabs",
"pos": [
31,
35
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
90,
100
]
} |
features of this preparation are 1 ) the very high yield of viable endothelial cells , 2 ) the absence of contamination by fibroblasts and smooth muscle cells and a very low contamination by erythrocytes and 3 ) the fine dispersion of the isolated cells . | NA | {
"id": "C0007634",
"name": "the",
"pos": [
37,
40
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
123,
134
]
} |
when the cells are left in diluted coelomic fluid , they exhibit a fibroblast-like mode of translocation across the substrate . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
9,
14
]
} | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
67,
77
]
} |
fibroblasts were seeded into dishes containing colloidal gold-coated cover glasses [ albrecht-buehler , 1977 ] , incubated for 24h at 37 degrees c , and the area of cell `` '' phagokinetic '' '' tracks determined . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
0,
11
]
} | {
"id": "C0007634",
"name": "the",
"pos": [
153,
156
]
} |
the mean track area ( +/- se ) for all control cells studied was 14.6 +/- 0.5 x 10 ( 3 ) micron2 whereas for ks fibroblasts was 8.7 +/- 0.4 x 10 ( 3 ) micron2 ( p less than 0.001 ) . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
47,
52
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
112,
123
]
} |
the viral sequences show no obvious rearrangements in these clones , but integration can be associated with deletions in the viral dna and also apparently in the host dna . | NA | {
"id": "C0012939",
"name": "viral dna",
"pos": [
125,
134
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
167,
170
]
} |
capping of cell surface antigen with okt4 , followed by staining with okt4 , 4a , 4b , 4c , or 4d , indicated that the epitopes for all five antibodies co-cap . | NA | {
"id": "C0003320",
"name": "antigen",
"pos": [
24,
31
]
} | {
"id": "C0003316",
"name": "epitopes",
"pos": [
119,
127
]
} |
the bx chickens also lacked both natural antibodies to phosphorylcholine , fecal bacteria , rabbit red blood cells ( rrbc ) , and mhc antigens and autoantibodies to the liver , kidney , and thyroidea . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
41,
51
]
} | {
"id": "C0004358",
"name": "autoantibodies",
"pos": [
147,
161
]
} |
this data represent the morphological counterpart of the abnormal fibroblast-fibrin interaction shown in a tridimensional model , where transformed cells were found unable to induce the retraction of a fibrin clot ( fcr ) . | NA | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
66,
76
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
148,
153
]
} |
the major bp-deoxyribonucleoside adduct detected in each skin sample appeared to be formed from the reaction of r-7 , t-8-dihydroxy-t-9,10-oxy-7,8,9,10-tetrahydrobenzo [ a ] pyrene ( anti-bp-7,8-diol 9,10-oxide ) with deoxyguanosine residues in dna . | NA | {
"id": "C0011528",
"name": "deoxyribonucleoside",
"pos": [
13,
32
]
} | {
"id": "C0011503",
"name": "deoxyguanosine",
"pos": [
218,
232
]
} |
[ a brief account of clinical research reported at the national seminars on deficiency syndrome and the prevention and treatment of gerontal diseases ] . | NA | {
"id": "C0039082",
"name": "syndrome",
"pos": [
87,
95
]
} | {
"id": "C0012634",
"name": "diseases",
"pos": [
141,
149
]
} |
naloxone 0.16 % ophthalmic drops or placebo drops were self-administered to one eye by 13 runners 250 times in a double-blind fashion over three weeks of various intensities and durations of running . | NA | {
"id": "C0015399",
"name": "ophthalmic drops",
"pos": [
16,
32
]
} | {
"id": "C0991568",
"name": "drops",
"pos": [
44,
49
]
} |
dimethylnitrosamine given after partial hepatectomy reduces the synthesis of dna , histone , and , to a lesser extent , of nonhistone proteins , the inhibition being general rather than for specific nuclear proteins . | NA | {
"id": "C0019652",
"name": "histone",
"pos": [
83,
90
]
} | {
"id": "C0028589",
"name": "nuclear proteins",
"pos": [
199,
215
]
} |
dimethylnitrosamine given after partial hepatectomy reduces the synthesis of dna , histone , and , to a lesser extent , of nonhistone proteins , the inhibition being general rather than for specific nuclear proteins . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
134,
142
]
} | {
"id": "C0028589",
"name": "nuclear proteins",
"pos": [
199,
215
]
} |
electrophoretic analysis of non-histone proteins revealed two reproducible effects of feeding the carcinogenic diet : relative to the bulk of nuclear non-histone protein , there was a reduction in the amount of a slightly basic 65000 mol . wt . polypeptide , and an increase in the level of a high molecular weight protein that was almost undetectable in material from normal rats . | NA | {
"id": "C0028589",
"name": "nuclear",
"pos": [
142,
149
]
} | {
"id": "C0019652",
"name": "histone",
"pos": [
154,
161
]
} |
cytosolic and contractile protein synthesis measured by [ 35s ] methionine incorporation into proteins was blocked 70 % overall in each fraction after 6 hours of incubation with 2 microm adriamycin . | NA | {
"id": "C0009915",
"name": "contractile protein",
"pos": [
14,
33
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
94,
102
]
} |
therefore , the calculated pk ' for the bicarbonate buffer system , which is derived from solutions lacking proteins , is not solely determined by the concentrations of bicarbonate , dissolved co2 , carbonate and carbonic acid when albumin is present . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
108,
116
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
232,
239
]
} |
therefore , the calculated pk ' for the bicarbonate buffer system , which is derived from solutions lacking proteins , is not solely determined by the concentrations of bicarbonate , dissolved co2 , carbonate and carbonic acid when albumin is present . | NA | {
"id": "C0005367",
"name": "bicarbonate",
"pos": [
40,
51
]
} | {
"id": "C0007026",
"name": "carbonate",
"pos": [
199,
208
]
} |
in dilutions of normal sera the liposome membranes undergo a rearrangement when divalent cations are added , resulting in the release of the encapsulated dye and the rapid formation of a stable blue cation-dye complex . | NA | {
"id": "C0007448",
"name": "divalent cations",
"pos": [
80,
96
]
} | {
"id": "C0007447",
"name": "cation",
"pos": [
199,
205
]
} |
we have evaluated the performance of optimate substrate-labeled fluorescent immunoassays for gentamicin , tobramycin , amikacin , theophylline , phenytoin , phenobarbital , primidone , carbamazepine , and quinidine with this automated system . | NA | {
"id": "C0031412",
"name": "phenobarbital",
"pos": [
157,
170
]
} | {
"id": "C0033148",
"name": "primidone",
"pos": [
173,
182
]
} |
the second new tool is one for detecting anions or cations separated by ion chromatography . | NA | {
"id": "C0003075",
"name": "anions",
"pos": [
41,
47
]
} | {
"id": "C0022023",
"name": "ion",
"pos": [
72,
75
]
} |
the second new tool is one for detecting anions or cations separated by ion chromatography . | NA | {
"id": "C0007447",
"name": "cations",
"pos": [
51,
58
]
} | {
"id": "C0022023",
"name": "ion",
"pos": [
72,
75
]
} |
urinary putrescine and spermidine concentrations in samples of morning spot urine were similar to those in 24-hour urine samples , and they were significantly increased in patients with various types of cancer . | NA | {
"id": "C0034170",
"name": "putrescine",
"pos": [
8,
18
]
} | {
"id": "C0037871",
"name": "concentrations",
"pos": [
34,
48
]
} |
there was a positive correlation between the degradative activity and indices of hepato-cellular synthetic function ( serum albumin , r = 0.77 ; serum prealbumin , r = 0.65 ) . | NA | {
"id": "C0036773",
"name": "serum albumin",
"pos": [
118,
131
]
} | {
"id": "C0032923",
"name": "prealbumin",
"pos": [
151,
161
]
} |
since reactive amyloidosis is extremely rare in liver cirrhosis , it seems obvious that a reduced amyloid degrading activity alone , in the absence of a markedly elevated saa level , does not predispose , at least in patients with liver disease , to amyloidosis . | NA | {
"id": "C0023890",
"name": "liver cirrhosis",
"pos": [
48,
63
]
} | {
"id": "C0023895",
"name": "liver disease",
"pos": [
231,
244
]
} |
this study indicates that the half-life of apo a-i seems not to be affected by the form in which the apoprotein is injected and that kinetics of apo a-i-phospholipid complexes may be used as a valid index of apoprotein a-i/hdl metabolism . | NA | {
"id": "C0018517",
"name": "half-life",
"pos": [
30,
39
]
} | {
"id": "C0022702",
"name": "kinetics",
"pos": [
133,
141
]
} |
although this process can be prevented by exchange of the hydroxyl group with sulphite , azide or nitrite ions , further separation of the respective cobalamin forms from the other endogenous cobalamins by hplc proved to be impossible . | NA | {
"id": "C0042845",
"name": "cobalamin",
"pos": [
150,
159
]
} | {
"id": "C0086024",
"name": "cobalamins",
"pos": [
192,
202
]
} |
the ratio between maximal and basal activity ( an expression of the degree of retention of the enzymes to lysosome ) of acid phosphatase was significantly decreased in patients with chronic active hepatitis and cirrhosis whereas that of cathepsin d did not show any significant changes between normal and various liver disorders . | NA | {
"id": "C0023890",
"name": "cirrhosis",
"pos": [
211,
220
]
} | {
"id": "C0023895",
"name": "liver disorders",
"pos": [
313,
328
]
} |
adrenal , thyroid , and growth-hormone insufficiency occurred as often in patients with an empty sella as in those with a solid pituitary tumour . | NA | {
"id": "C0014008",
"name": "empty sella",
"pos": [
91,
102
]
} | {
"id": "C0032002",
"name": "pituitary",
"pos": [
128,
137
]
} |
there was no difference in the mean androgen receptor content ( approximately 10 000 sites/cell ) or binding affinity ( approximately 1 nm ) between the patients ' fibroblasts and those of the normal subjects . | NA | {
"id": "C0007634",
"name": "cell",
"pos": [
91,
95
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
164,
175
]
} |
plasma cortisol , corticosterone , 11-deoxycorticosterone , 18-hydroxycorticosterone ( 18-ohb ) , and aldosterone responses to graded doses of angiotensin ii and acth were evaluated in six healthy male volunteers with and without treatment with the dopamine agonist bromocriptine ( bec ) . | NA | {
"id": "C0010124",
"name": "corticosterone",
"pos": [
18,
32
]
} | {
"id": "C0000172",
"name": "18-hydroxycorticosterone",
"pos": [
60,
84
]
} |
baseline norepinephrine , epinephrine , and dopamine were significantly higher in anephric versus intact animals and did not change significantly after b-blockade except for norepinephrine of the anephric rats which decreased . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
12,
23
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
174,
188
]
} |
however , the difference in serum phe concentration of the ph degrees and ph- groups reached statistical significance at 24 h postloading ( p less than 0.01 ) . | NA | {
"id": "C0020364",
"name": "ph",
"pos": [
34,
36
]
} | {
"id": "C0031456",
"name": "ph",
"pos": [
74,
76
]
} |
we conclude that agu may be more common in non-finnish populations than the number of reported cases would indicate and should be included in the differential diagnosis in patients with suspected lysosomal storage disorders regardless of their geographical or ethnic backgrounds . | NA | {
"id": "C0268225",
"name": "agu",
"pos": [
17,
20
]
} | {
"id": "C0085078",
"name": "lysosomal storage disorders",
"pos": [
196,
223
]
} |
removal of tg binding cells from pbm or b cell preparations resulted in greater than 85 % reduction in their ability to synthesize tg antibody when stimulated with pokeweed mitogen ( pwm ) or eb virus ( ebv ) ; | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
22,
27
]
} | {
"id": "C1321301",
"name": "pbm",
"pos": [
33,
36
]
} |
hashimoto lymphocytes ( pbm or b cells ) enriched for tg binding cells produced only small amounts of tg antibody when cultured with pwm even in the presence of irradiated t cells and monocytes ; | NA | {
"id": "C1321301",
"name": "pbm",
"pos": [
24,
27
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
174,
179
]
} |
the ability to isolate tg specific b cells from peripheral blood will facilitate the development of ebv transformed cell lines secreting monoclonal tg antibody and such antibodies will provide invaluable probes in the investigation of autoimmune thyroid disease . | NA | {
"id": "C0003250",
"name": "monoclonal",
"pos": [
137,
147
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
169,
179
]
} |
after doing a second culture for 6 days , we measured the suppressive influence of these cells on t lymphocyte proliferation rates stimulated with allogeneic mononuclear cells , and b lymphocyte proliferation rates stimulated with pokeweed mitogen . | NA | {
"id": "C0007634",
"name": "the",
"pos": [
54,
57
]
} | {
"id": "C3485979",
"name": "allogeneic",
"pos": [
147,
157
]
} |
furthermore , major suppressor activity was found in the okt8+ t-cell subpopulations in cbmc and three out of four cvh patients . | NA | {
"id": "C0007634",
"name": "cell",
"pos": [
65,
69
]
} | {
"id": "C1321301",
"name": "cbmc",
"pos": [
88,
92
]
} |
there was no significant difference in relative suppression by okt8+ cells from normal adults , cvh patients , or cbmc . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
69,
74
]
} | {
"id": "C1321301",
"name": "cbmc",
"pos": [
114,
118
]
} |
when non-e-rosetting cells from normal subjects , cvh , and cbmc were stimulated with ebv it was observed that normal adult b cells could be induced to secrete igg , igm , and ig-rf whereas cvh and cbmc could only produce igm and igm-rf but not igg . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
21,
26
]
} | {
"id": "C1321301",
"name": "cbmc",
"pos": [
198,
202
]
} |
the sm antigen had a mol . wt of 68,000 and was noted to 'co-purify ' with the nrnp antigen . | NA | {
"id": "C0003320",
"name": "antigen",
"pos": [
7,
14
]
} | {
"id": "C0069115",
"name": "nrnp antigen",
"pos": [
79,
91
]
} |
although the presence of free dna and antibodies to dna in the sera of patients on maintenance hemodialysis has been reported , we found only a low incidence of antibodies to single-stranded dna ( ss-dna ) and native dna ( n-dna ) using an improved detection technique . | NA | {
"id": "C0012935",
"name": "single-stranded dna",
"pos": [
175,
194
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
225,
228
]
} |
the major differences in electrolyte and albumin concns in airway fluid and plasma likely reflect a bidirectional transepithelial flux of these ions . | NA | {
"id": "C0013832",
"name": "electrolyte",
"pos": [
25,
36
]
} | {
"id": "C0022023",
"name": "ions",
"pos": [
144,
148
]
} |
for all degrees of comminution , group 1 includes the spiral fractures and groups 2 and 3 the nonspiral bending fractures . | NA | {
"id": "C0476171",
"name": "comminution",
"pos": [
19,
30
]
} | {
"id": "C0016658",
"name": "fractures",
"pos": [
112,
121
]
} |
sometimes this syndrome is part of a multisystemic disorder in which organomegaly , endocrine disturbances , skin changes and focal bone lesions may also occur . | NA | {
"id": "C0039082",
"name": "syndrome",
"pos": [
15,
23
]
} | {
"id": "C0012634",
"name": "disorder",
"pos": [
51,
59
]
} |
a comparative study was done in women and men of the effects of delta 9-tetrahydrocannabinol ( delta 9-thc ) , intravenously or orally , on dynamic activity , metabolism , excretion , and kinetics . | NA | {
"id": "C0025519",
"name": "metabolism",
"pos": [
159,
169
]
} | {
"id": "C0221102",
"name": "excretion",
"pos": [
172,
181
]
} |
the charcoal-broiled beef had little or no effect on the plasma-level profile of acetaminophen , acetaminophen glucuronide and acetaminophen sulfate , or on the urinary excretion of acetaminophen , acetaminophen glucuronide , acetaminophen sulfate , 3-methoxy-acetaminophen , or the cysteine and mercapturic acid conjugates of acetaminophen . | NA | {
"id": "C0010654",
"name": "cysteine",
"pos": [
283,
291
]
} | {
"id": "C0001047",
"name": "mercapturic acid",
"pos": [
296,
312
]
} |
whether amino acids were ingested as protein or in the free state , glycine , alanine and glutamine increased in the mucosa , suggesting these three incorporate nitrogen released from the others . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
8,
19
]
} | {
"id": "C0017890",
"name": "glycine",
"pos": [
68,
75
]
} |
whether amino acids were ingested as protein or in the free state , glycine , alanine and glutamine increased in the mucosa , suggesting these three incorporate nitrogen released from the others . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
8,
19
]
} | {
"id": "C0001898",
"name": "alanine",
"pos": [
78,
85
]
} |
the plasminogen-streptokinase complex is an activator of plasminogen and is rapidly converted to a plasmin-streptokinase complex which , in the human , is also an activator of plasminogen . | NA | {
"id": "C0038418",
"name": "streptokinase",
"pos": [
16,
29
]
} | {
"id": "C0032144",
"name": "activator",
"pos": [
163,
172
]
} |
like chicken albumin , smwp is more closely homologous with bovine albumin than with human albumin . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
13,
20
]
} | {
"id": "C0304925",
"name": "human albumin",
"pos": [
85,
98
]
} |
in all species the surface lipid mixtures consisted of giant-ring lactones , cholesterol , cholesteryl esters and minor amounts of wax diesters . | NA | {
"id": "C0023779",
"name": "lipid",
"pos": [
27,
32
]
} | {
"id": "C0043076",
"name": "wax",
"pos": [
131,
134
]
} |
in all species the surface lipid mixtures consisted of giant-ring lactones , cholesterol , cholesteryl esters and minor amounts of wax diesters . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
77,
88
]
} | {
"id": "C0008387",
"name": "cholesteryl esters",
"pos": [
91,
109
]
} |
rosette formation and decreased binding of the chemically modified ldl suggested that the intact protein moiety of lipoproteins was essential for the transfer of lipids from ldl to elastin . | NA | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
115,
127
]
} | {
"id": "C0023779",
"name": "lipids",
"pos": [
162,
168
]
} |
alfentanil has a shorter duration of action and is claimed to have less postoperative ventilatory depression than fentanyl . | NA | {
"id": "C0002026",
"name": "alfentanil",
"pos": [
0,
10
]
} | {
"id": "C0015846",
"name": "fentanyl",
"pos": [
114,
122
]
} |
based on the clinical impressions of our european colleagues , one can say that these agents should be as safe and as reliable as fentanyl , but any clinically significant advantages over their parent compound , especially in the case of sufentanil , will have to await more widespread use and controlled investigation . | NA | {
"id": "C0015846",
"name": "fentanyl",
"pos": [
130,
138
]
} | {
"id": "C0143993",
"name": "sufentanil",
"pos": [
238,
248
]
} |
plasma concentrations of ne and epi increased significantly ( p less than 0.01 ) as core temperature fell from 37 degrees to 31 degrees c , but as core temperature dropped from 31 degrees to 29 degrees c , plasma ne and epi levels decreased towards prehypothermic concentrations . | NA | {
"id": "C0014563",
"name": "epi",
"pos": [
32,
35
]
} | {
"id": "C0028351",
"name": "ne",
"pos": [
213,
215
]
} |
in contrast to earlier reports , all the cells studied were found to freeze at temperatures above that indicated for homogeneous nucleation of ice in undercooled liquid water . | NA | {
"id": "C0020746",
"name": "ice",
"pos": [
143,
146
]
} | {
"id": "C0043047",
"name": "water",
"pos": [
169,
174
]
} |
studies were conducted on the viability of micrococcus varians strain m95 and lactobacillus plantarum strain l4 upon freezing and freeze-drying using five cryoprotectants ( sucrose , lactose , sodium glutamate , peptone , dry nonfat milk ) singly or in combinations with gelatin , glutamic acid , and sodium acetate . | NA | {
"id": "C0037511",
"name": "sodium glutamate",
"pos": [
193,
209
]
} | {
"id": "C0061472",
"name": "glutamic acid",
"pos": [
281,
294
]
} |
single-breath carbon monoxide diffusing capacity ( dsb ) was measured before and during immersion of one hand in ice water ( cold pressor test ) in the following three groups of subjects : ( 1 ) normal subjects ; | NA | {
"id": "C0020746",
"name": "ice",
"pos": [
113,
116
]
} | {
"id": "C0043047",
"name": "water",
"pos": [
117,
122
]
} |
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