id
stringlengths
1
5
tokens
sequence
ner_tags
sequence
3972
[ "These", "results", "indicate", "that", "the", "BCL-6", "protein", "can", "function", "as", "a", "sequence-specific", "transcriptional", "repressor", "and", "have", "implications", "for", "the", "role", "of", "BCL6", "in", "normal", "lymphoid", "development", "and", "lymphomagenesis", "." ]
[ 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 9, 10, 10, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0 ]
15572
[ "Binding", "of", "125I-labeled", "aldosterone", "to", "plasma", "membranes", "of", "HML", "shares", "important", "features", "with", "these", "functional", "data", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 7, 0, 0, 0, 0, 0, 0, 0, 0 ]
3324
[ "T", "cell", "response", "to", "Epstein-Barr", "virus", "transactivators", "in", "chronic", "rheumatoid", "arthritis", "." ]
[ 0, 0, 0, 0, 9, 10, 10, 0, 0, 0, 0, 0 ]
3802
[ "Glucocorticoids", "and", "interferon-alpha", "in", "the", "acquired", "immunodeficiency", "syndrome", "." ]
[ 0, 0, 9, 0, 0, 0, 0, 0, 0 ]
15943
[ "Nonetheless", "transcription", "of", "both", "the", "endogenous", "and", "the", "transfected", "gene", "was", "inducible", "by", "PMA", "treatment", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
11700
[ "The", "transcription", "factor", "Pax-5", "is", "expressed", "during", "the", "early", "stages", "of", "B-cell", "differentiation", "and", "influences", "the", "expression", "of", "several", "B-cell-specific", "genes", "." ]
[ 0, 9, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0 ]
1557
[ "Induction", "of", "TaxI", "in", "a", "human", "T-cell", "line", "Jurkat", "carrying", "the", "TaxI", "gene", "under", "the", "metallothionein", "promoter", "led", "to", "increases", "in", "mRNA", "and", "surface", "expression", "of", "ICAM-I", "." ]
[ 0, 0, 9, 0, 0, 5, 6, 6, 6, 0, 0, 1, 2, 0, 0, 1, 2, 0, 0, 0, 0, 3, 0, 0, 0, 0, 9, 0 ]
9376
[ "Similar", "transfection", "analysis", "of", "the", "-66", "to", "-59", "region", "of", "the", "CD11b", "promoter", "showed", "Sp3", "-dependent", "expression", "." ]
[ 0, 0, 0, 0, 0, 1, 2, 2, 2, 0, 0, 1, 2, 0, 9, 0, 0, 0 ]
4957
[ "IL-1alpha", "promoter", "constructs", "drive", "transcription", "of", "the", "chloramphenicol", "acetyltransferase", "(", "CAT", ")", "reporter", "gene", "in", "HTLV-I-positive", "MT-2", "cells", ",", "which", "constitutively", "produce", "IL-1alpha", "." ]
[ 1, 2, 2, 0, 0, 0, 0, 1, 2, 2, 2, 2, 2, 2, 0, 5, 6, 6, 0, 0, 0, 0, 9, 0 ]
17445
[ "In", "contrast", ",", "other", "viral", "and", "cellular", "products", "have", "not", "been", "influenced", "by", "the", "level", "of", "H-7", "used", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
6938
[ "Finally", ",", "PPARalpha", "activators", "significantly", "reduced", "adhesion", "of", "U937", "cells", "to", "cultured", "human", "ECs", "." ]
[ 0, 0, 9, 0, 0, 0, 0, 0, 5, 6, 0, 7, 8, 8, 0 ]
16434
[ "CONCLUSIONS", ":", "These", "results", "provide", "further", "evidence", "for", "a", "dysregulation", "of", "the", "HPA", "axis", "in", "PTSD", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
2374
[ "There", "was", "no", "apparent", "correlation", "between", "serum", "testosterone", "concentrations", "and", "androgen", "binding", "sites", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0 ]
11218
[ "Taken", "together", ",", "these", "data", "indicate", "that", "Tax1", "interacts", "with", "NF-Y", "through", "the", "B", "subunit", "and", "that", "this", "interaction", "results", "in", "activation", "of", "the", "major", "histocompatibility", "complex", "class", "II", "promoter", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 9, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 2, 2, 2, 0 ]
13648
[ "IL-7", "also", "delayed", "the", "decreases", "in", "the", "levels", "of", "c-Myc", ",", "Bcl-2", ",", "and", "Bcl-xL", "that", "occur", "upon", "loss", "of", "v-Abl", "kinase", "activity", "." ]
[ 9, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 9, 0, 0, 9, 0, 0, 0, 0, 0, 9, 0, 0, 0 ]
17159
[ "(", "ABSTRACT", "TRUNCATED", "AT", "250", "WORDS", ")" ]
[ 0, 0, 0, 0, 0, 0, 0 ]
14044
[ "CONCLUSION", ":", "Monocytes", ",", "T", "cells", ",", "and", "B", "cells", "in", "patients", "express", "transcripts", "of", "the", "normal", "wild", "type", "ER", "and", "the", "hormone", "binding", "domain", "variants", "in", "vivo", "." ]
[ 0, 0, 7, 0, 7, 8, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 0, 9, 10, 10, 10, 0, 0, 0 ]
2449
[ "Taken", "together", ",", "these", "data", "suggest", "that", "hypoxia", "constitutes", "a", "stimulus", "for", "leukocyte", "chemotaxis", "and", "tissue", "leukostasis", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
17409
[ "Despite", "their", "similar", "effects", "the", "drugs", "bind", "to", "two", "different", "cytosolic", "protein", ",", "cyclophilin", "and", "FKBP", "respectively", ",", "which", "raises", "the", "possibility", "that", "they", "have", "different", "modes", "of", "action", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 9, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
4714
[ "Therefore", ",", "we", "sought", "to", "determine", "whether", "MEK1", "and", "ERK", "activities", "also", "stimulate", "IL-2", "gene", "transcription", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 9, 0, 9, 0, 0, 0, 1, 2, 0, 0 ]
4462
[ "Several", "recent", "studies", "have", "suggested", "that", "interleukin", "(", "IL", ")", "-6", "may", "be", "used", "to", "detect", "both", "infection", "and", "rejection", "after", "lung", "transplantation", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
1347
[ "Furthermore", ",", "retinoic", "acid", "receptor", "(", "RAR", ")", "alpha", "is", "able", "to", "inhibit", "in", "vitro", "the", "formation", "of", "the", "complex", "between", "the", "nuclear", "AP-1", "/OAP", "and", "its", "specific", "binding", "site", ",", "resulting", "in", "the", "interference", "with", "Oct-2", "-dependent", "cis-regulatory", "function", "of", "this", "AP-1", "element", "." ]
[ 0, 0, 9, 10, 10, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 9, 0, 0 ]
17970
[ "The", "human", "activation", "antigen", "CD69", "is", "a", "member", "of", "the", "C-type", "animal", "lectin", "superfamily", "that", "functions", "as", "a", "signal-transmitting", "receptor", "." ]
[ 0, 9, 10, 10, 9, 0, 0, 0, 0, 0, 9, 10, 10, 10, 0, 0, 0, 0, 9, 10, 0 ]
16554
[ "The", "retrodifferentiated", "cells", "detached", "from", "the", "substrate", "and", "reinitiated", "proliferation", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
10015
[ "Taken", "together", ",", "these", "findings", "strongly", "suggest", "that", "SR-BP", "represents", "the", "molecular", "target", "for", "SR", "31747A", "in", "mammalian", "tissues", ",", "which", "could", "be", "critical", "for", "T", "cell", "proliferation", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
12675
[ "These", "results", "suggest", "that", "activation", "of", "Stat4", ",", "which", "is", "necessary", "for", "the", "differentiation", "of", "naive", "T", "cells", "into", "polarized", "Th1", "cells", ",", "is", "not", "sufficient", "to", "induce", "phenotype", "reversal", "of", "human", "Th2", "cells", "." ]
[ 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 8, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 8, 0 ]
14076
[ "These", "experiments", "are", "of", "prime", "importance", "considering", "that", "CD4-expressing", "T", "lymphocytes", "represent", "the", "major", "virus", "reservoir", "in", "the", "peripheral", "blood", "of", "infected", "individuals", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
10119
[ "Genomic", "organization", ",", "sequence", ",", "and", "transcriptional", "regulation", "of", "the", "human", "eotaxin", "gene", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 0 ]
15076
[ "Together", ",", "this", "evidence", "strongly", "implicates", "BSAP", "in", "the", "regulation", "of", "the", "CD19", "gene", "." ]
[ 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 1, 2, 0 ]
2728
[ "Ara-C", "activated", "JNKs", "only", "after", "prolonged", "incubation", "(", "90-120", "minutes", ")", "." ]
[ 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
14137
[ "Multiple", "TcR", "delta", "transcripts", "deriving", "from", "an", "unrearranged", "TcR", "delta", "gene", "were", "detected", "in", "both", "polyclonal", "and", "clonal", "CD3-CD16+", "natural", "killer", "(", "NK", ")", "cell", "lines", "." ]
[ 0, 9, 10, 10, 0, 0, 0, 0, 1, 2, 2, 0, 0, 0, 0, 5, 6, 6, 6, 6, 6, 6, 6, 6, 6, 6, 0 ]
17028
[ "However", ",", "one", "palindrome", ",", "either", "alone", "or", "duplicated", ",", "or", "the", "overlapping", "palindromes", "did", "not", "respond", "to", "R", "." ]
[ 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0 ]
4094
[ "Instead", ",", "ATF-2", "and", "Jun", "proteins", "bind", "to", "the", "composite", "kappa", "3/CRE", "site", "and", "NFATp", "binds", "to", "a", "newly", "identified", "second", "NFAT", "site", "centered", "at", "-76", "nucleotides", "relative", "to", "the", "TNF-alpha", "transcription", "start", "site", "." ]
[ 0, 0, 9, 0, 9, 10, 0, 0, 0, 1, 2, 2, 2, 0, 9, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 1, 2, 0, 0, 0, 1, 2, 2, 2, 0 ]
12252
[ "Forty-eight", "hours", "after", "transfection", ",", "EC", "were", "stimulated", "with", "NK", "cells", "or", "NK", "cell", "membrane", "extracts", "for", "7", "hr", "and", "activation", "was", "measured", "by", "a", "luciferase", "assay", "." ]
[ 0, 0, 0, 0, 0, 7, 0, 0, 0, 7, 8, 0, 7, 8, 8, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0 ]
3803
[ "Some", "patients", "with", "acquired", "immunodeficiency", "syndrome", "(", "AIDS", ")", "develop", "glucocorticoid", "resistance", "characterized", "by", "low", "receptor", "affinity", "(", "Kd", ")", "for", "glucocorticoids", "in", "mononuclear", ",", "cells", "and", "high", "values", "of", "ACTH", "and", "cortisol", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
10906
[ "Taken", "together", ",", "these", "data", "suggest", "that", "EBF", "and", "E47", "synergize", "to", "activate", "expression", "of", "a", "subset", "of", "genes", "that", "define", "an", "early", "stage", "of", "the", "B", "cell", "lineage", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 9, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 8, 0 ]
17195
[ "A", "small", "95-bp", "fragment", "of", "the", "TCR", "alpha", "control", "region", "that", "contains", "the", "TCF-1", "alpha", "binding", "site", "juxtaposed", "between", "a", "cAMP-response", "element", "(", "the", "CRE", "or", "T", "alpha", "1", "motif", ")", "and", "the", "binding", "site", "for", "a", "distinct", "lymphoid-specific", "protein", "(", "TCF-2", "alpha", ")", "behaved", "as", "a", "potent", "T-cell-specific", "enhancer", "in", "vivo", "." ]
[ 0, 0, 0, 0, 0, 0, 1, 2, 2, 2, 0, 0, 0, 1, 2, 2, 2, 0, 0, 0, 1, 2, 0, 0, 1, 0, 1, 2, 2, 2, 0, 0, 0, 1, 2, 0, 0, 0, 9, 10, 0, 9, 10, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0 ]
16475
[ "Thus", "the", "inhibitory", "effect", "of", "insulin", "on", "the", "GR", "binding", "power", "is", "both", "dose-", "and", "time-dependent", ",", "which", "strongly", "suggests", "that", "GR", "is", "tonically", "controlled", "by", "insulin", "concentration", "change", "under", "physiological", "conditions", "." ]
[ 0, 0, 0, 0, 0, 9, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0 ]
13221
[ "However", ",", "retroviral", "transduction", "of", "GATA-3", "into", "developing", "T", "cells", "induced", "IL-5", "to", "full", "Th2", "levels", ",", "but", "only", "partially", "restored", "IL-4", "production", "." ]
[ 0, 0, 0, 0, 0, 9, 0, 7, 8, 8, 0, 9, 0, 0, 9, 0, 0, 0, 0, 0, 0, 9, 0, 0 ]
7339
[ "This", "was", "not", "the", "case", "when", "PBMC", "were", "pre-cultured", "in", "plastic", "multidishes", "in", "the", "presence", "of", "IL-10", "." ]
[ 0, 0, 0, 0, 0, 0, 7, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0 ]
9790
[ "Many", "of", "these", "events", "are", "dependent", "upon", "the", "ability", "of", "CD40", "to", "activate", "the", "transcription", "factor", "NF-kappa", "B", "(", "NF-kappa", "B", ")", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 9, 10, 0, 9, 10, 0, 0 ]
4377
[ "Dexamethasone", "inhibited", "LPS-induced", "bioactive", "IL-12", "production", "in", "a", "dose-dependent", "fashion", "and", "at", "physiologically", "relevant", "concentrations", ";", "it", "had", "no", "effect", "on", "IL-10", "secretion", "." ]
[ 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0 ]
2582
[ "CD14", "-mediated", "translocation", "of", "nuclear", "factor-kappa", "B", "induced", "by", "lipopolysaccharide", "does", "not", "require", "tyrosine", "kinase", "activity", "." ]
[ 9, 0, 0, 0, 9, 10, 10, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0 ]
174
[ "Our", "results", "suggest", "that", "SP1", "phosphorylation", "induced", "by", "OKA", ",", "a", "selective", "inhibitor", "of", "the", "serine-threonine", "phosphatase", "PP2A", ",", "facilitates", "the", "formation", "of", "a", "transcription", "complex", "involving", "general", "transcription", "factors", ",", "HIV", "Tat", ",", "and", "Sp1", "proteins", "." ]
[ 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 9, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 9, 10, 0, 9, 10, 0, 0, 9, 10, 0 ]
13075
[ "Transcriptional", "regulation", "of", "lysosomal", "acid", "lipase", "in", "differentiating", "monocytes", "is", "mediated", "by", "transcription", "factors", "Sp1", "and", "AP-2", "." ]
[ 0, 0, 0, 9, 10, 10, 0, 0, 0, 0, 0, 0, 9, 10, 9, 0, 9, 0 ]
15549
[ "Our", "results", "indicate", "that", "the", "AP-1", "site", "at", "-150", "bp", "represents", "a", "major", ",", "if", "not", "the", "only", ",", "site", "of", "PKC", "responsiveness", "in", "the", "IL-2", "promoter", "." ]
[ 0, 0, 0, 0, 0, 1, 2, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 1, 2, 0 ]
17169
[ "A", "group", "of", "coordinately", "induced", "protooncogenes", ",", "cytoskeletal", ",", "and", "extracellular", "matrix", "genes", "have", "been", "termed", "immediate", "early", "response", "genes", ",", "and", "their", "induction", "has", "been", "associated", "with", "growth", "factor", "-stimulated", "cell", "proliferation", "." ]
[ 0, 0, 0, 0, 0, 1, 0, 1, 2, 2, 2, 2, 2, 0, 0, 0, 1, 2, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0 ]
1689
[ "Sequencing", "of", "the", "genomic", "region", "between", "the", "exons", "1", "and", "2", "showed", "that", "the", "alternative", "5'-end", "is", "a", "part", "of", "the", "intron", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 2, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 1, 0 ]
18433
[ "Order", "of", "addition", "and", "off-rate", "experiments", "indicate", "that", "the", "VDR-retinoid", "X", "receptor", "heterodimer", "blocks", "NFATp/AP-1", "complex", "formation", "and", "then", "stably", "associates", "with", "the", "NF-AT-1", "element", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0 ]
13512
[ "The", "transition", "of", "Epstein-Barr", "virus", "(", "EBV", ")", "from", "latency", "into", "the", "lytic", "cycle", "is", "associated", "with", "the", "expression", "of", "two", "immediate-early", "viral", "genes", ",", "BZLF1", "and", "BRLF1", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 0, 1, 0, 1, 0 ]
11850
[ "The", "ferritin", "H-chain", "gene", "promoter", "regulation", "was", "analyzed", "in", "heme-treated", "Friend", "leukemia", "cells", "(", "FLCs", ")", "and", "during", "monocyte-to-macrophage", "differentiation", "." ]
[ 0, 1, 2, 2, 2, 0, 0, 0, 0, 5, 6, 6, 6, 0, 5, 0, 0, 0, 0, 0, 0 ]
9865
[ "Peripheral", "blood", "mononuclear", "cells", "from", "atopic", "asthma", "patients", "both", "proliferated", "and", "produced", "IL-5", "after", "incubation", "with", "mite", "allergen", ",", "suggesting", "that", "mite-specific", "helper", "T", "cells", "were", "involved", "in", "the", "eosinophilic", "inflammation", "of", "atopic", "asthma", "." ]
[ 7, 8, 8, 8, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 8, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
5398
[ "The", "resultant", "cell", "line", ",", "DH42", ",", "was", "hygromycin", "resistant", ",", "contained", "VDR", "cDNA", ",", "expressed", "fewer", "VDRs", "than", "controls", ",", "and", "showed", "a", "substantial", "decrease", "in", "antiproliferative", "response", "to", "1", ",", "25", "(", "OH", ")", "2D3", "." ]
[ 0, 5, 6, 6, 0, 5, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
5135
[ "We", "suggest", "that", "these", "phosphoproteins", "may", "be", "directly", "involved", "in", "regulating", "the", "transcriptional", "response", "to", "cellular", "activation", "by", "external", "stimuli", "." ]
[ 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
2697
[ "Since", "these", "hybrids", "preferentially", "segregate", "human", "chromosomes", ",", "these", "results", "indicate", "the", "existence", "of", "a", "non-syntenic", "trans-active", "locus", ",", "or", "loci", ",", "positively", "controlling", "the", "expression", "of", "the", "human", "CD5", "gene", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 0 ]
14079
[ "It", "was", "also", "determined", ",", "using", "electrophoresis", "mobility", "shift", "assays", ",", "that", "M.", "tuberculosis", "ManLAM", "led", "to", "the", "nuclear", "translocation", "of", "the", "transcription", "factor", "NF-kappaB", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0 ]
6678
[ "We", "had", "previously", "shown", "that", "the", "drug", "undecylprodigiosin", "(", "UP", ")", "blocks", "human", "lymphocyte", "proliferation", "in", "vitro", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0, 0, 0, 0 ]
1756
[ "Deletion", "of", "the", "5'-most", "Ets", "site", "had", "no", "effect", "on", "binding", "to", "GABP", "alpha/GABP", "beta", ",", "but", "it", "eliminated", "a", "." ]
[ 0, 0, 0, 1, 2, 2, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 0, 0, 0, 0, 0 ]
7452
[ "In", "the", "human", ",", "this", "may", "also", "occur", "via", "IFN-alpha", ",", "which", "is", "able", "to", "activate", "Stat4", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 9, 0 ]
2827
[ "Tepoxalin", "also", "inhibited", "the", "secretion", "of", "a", "NF-kappa", "B", "regulated", "chemokine", ",", "IL-8", ",", "a", "known", "inducer", "of", "CD11b/CD18", "expression", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 0, 9, 0, 0, 0, 0, 0, 9, 0, 0 ]
15598
[ "It", "has", "been", "found", "that", "the", "number", "of", "glucocorticoid", "receptors", "in", "lymphocytes", "of", "the", "peripheral", "blood", "of", "healthy", "elderly", "subjects", "increases", ",", "while", "the", "number", "of", "mineralocorticoid", "receptors", "decreases", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 7, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
5354
[ "While", "partial", "variable", "monosomy", "of", "loci", "on", "chromosome", "17p", "can", "not", "be", "excluded", "as", "contributing", "to", "the", "phenotype", "in", "this", "patient", ",", "it", "is", "argued", "that", "the", "major", "likely", "factor", "is", "partial", "functional", "disomy", "of", "sequences", "on", "Xp", "in", "cell", "lineages", "that", "have", "failed", "to", "inactivate", "the", "intact", "X", "chromosome", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0 ]
17030
[ "The", "clinical", "implications", "of", "nuclear", "T3R", "alterations", "of", "circulating", "lymphocytes", "in", "hyperthyroidism", ",", "hypothyroidism", "and", "nonthyroidal", "diseases", "were", "investigated", "." ]
[ 0, 0, 0, 0, 0, 9, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
119
[ "Taken", "together", ",", "our", "data", "suggest", "that", "p95vav", "plays", "an", "important", "role", "at", "an", "yet", "unidentified", "proximal", "position", "in", "the", "TCR", "signaling", "cascade", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0 ]
4173
[ "Sialoadhesin", "expression", "was", "functional", "as", "shown", "by", "cell", "adhesion", "assays", "with", "human", "RBCs", "." ]
[ 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0 ]
17150
[ "TAR", "independent", "activation", "of", "the", "human", "immunodeficiency", "virus", "in", "phorbol", "ester", "stimulated", "T", "lymphocytes", "." ]
[ 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0 ]
552
[ "However", ",", "B", "cells", "can", "also", "synthesize", "IL-2", "." ]
[ 0, 0, 7, 8, 0, 0, 0, 9, 0 ]
11974
[ "The", "ligand-binding", "domain", "(", "amino", "acids", "528-777", ")", "of", "the", "squirrel", "monkey", "glucocorticoid", "receptor", "contains", "four", "amino", "acid", "differences", "(", "Ser551", "to", "Thr", ",", "Ser616", "to", "Ala", ",", "Ala618", "to", "Ser", ",", "and", "Ile761", "to", "Leu", ")", ",", "all", "of", "which", "are", "present", "in", "owl", "monkey", "and", "cotton-top", "tamarin", "receptors", "." ]
[ 0, 9, 10, 0, 9, 10, 10, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 10, 10, 0 ]
14436
[ "One", "of", "the", "essential", "proteins", "which", "bound", "to", "the", "enhancer", "was", "similar", "or", "identical", "to", "members", "of", "the", "C/EBP", "family", "of", "transcription", "factors", "required", "for", "both", "IL-1", "-and", "LPS-specific", "induction", "of", "the", "IL-6", "gene", "(", "i.e.", ",", "the", "NF-IL6", "proteins", ")", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 9, 10, 0, 0, 0, 9, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 1, 2, 0, 0 ]
10321
[ "We", "conclude", "that", "NF-kappa", "B", "activation", "could", "constitute", "one", "of", "the", "mechanisms", "whereby", "the", "expression", "of", "kappa", "B-responsive", "genes", "is", "enhanced", "in", "phagocytosing", "neutrophils", "." ]
[ 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 0, 0, 0, 7, 8, 0 ]
14403
[ "Nuclear", "factor", "NF-kB", ",", "activation", "protein", "1", "(", "AP-1", ")", ",", "OCT-1", ",", "and", "NF-IL-2B", "binding", "activity", "were", "normal", "." ]
[ 9, 10, 10, 0, 9, 10, 10, 0, 9, 0, 0, 9, 0, 0, 9, 0, 0, 0, 0, 0 ]
17996
[ "If", ",", "as", "the", "literature", "suggests", ",", "NK", "activity", "is", "relevant", "to", "breast", "cancer", "control", ",", "and", "since", "ER", "-tumors", "have", "a", "worse", "prognosis", ",", "we", "suggest", "here", "that", "perhaps", "such", "tumors", "are", "resistant", "to", "control", "by", "NK", "cells", "because", "they", "lack", "the", "ability", "to", "attract", "an", "accumulation", "of", "effector", "cells", "to", "the", "tumor", "site", ",", "or", "because", "blocking", "factors", "at", "the", "site", "of", "the", "tumor", "prevent", "local", "tumor", "control", "at", "the", "site", "of", "action", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
10707
[ "For", "this", "purpose", ",", "we", "transiently", "transfected", "Jurkat", "T", "cells", "with", "the", "reporter", "plasmid", "p", "[", "(", "TRE", ")", "3-tk-Luc", "]", "and", "found", "that", "CCK-8", "was", "able", "to", "dose-dependently", "induce", "luciferase", "expression", "related", "to", "activator", "protein-1", "(", "AP-1", ")", "activation", "with", "a", "maximal", "response", "identical", "to", "that", "obtained", "with", "compounds", "known", "to", "activate", "AP-1", "complex", "(", "quantitatively", ",", "the", "same", "level", "of", "induction", "was", "obtained", "with", "1", "nM", "12-O-tetradecanoylphorbol-13-acetate", ",", "100", "microM", "diacylglycerol", ",", "or", "4", "nM", "epidermal", "growth", "factor", ")", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 5, 6, 6, 0, 0, 1, 2, 2, 2, 2, 2, 2, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 9, 10, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
5746
[ "In", "many", "circumstances", "it", "is", "difficult", "to", "distinguish", "the", "effects", "of", "CD28", "from", "subsequent", "actions", "of", "cytokines", ",", "such", "as", "IL-2", ",", "on", "T", "cell", "proliferation", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 9, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0 ]
11743
[ "On", "electromobility", "shift", "assays", "(", "EMSA", ")", "a", "single", "E2F-DNA", "binding", "complex", "was", "detected", "in", "T", "cells", ",", "B", "cells", "and", "monocytes", "which", "was", "shown", "to", "contain", "E2F-4", ",", "DP-1", "and", "p130", ",", "indicating", "that", "all", "quiescent", "haemopoietic", "cells", "have", "the", "same", "complex", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 0, 0, 7, 8, 0, 7, 8, 0, 7, 0, 0, 0, 0, 0, 9, 0, 9, 0, 9, 0, 0, 0, 0, 7, 8, 8, 0, 0, 0, 0, 0 ]
3025
[ "Regulation", "of", "cytokine", "and", "cytokine", "receptor", "expression", "by", "glucocorticoids", "." ]
[ 0, 0, 9, 0, 9, 10, 0, 0, 0, 0 ]
5662
[ "In", "contrast", ",", "APC", "pulsed", "with", "Ala-substituted", "peptides", "430-444", ",", "442A", "or", "433-442A", "at", "neutral", "pH", "failed", "to", "stimulate", "the", "T", "cell", "clone", ",", "while", "APC", "pulsed", "at", "acidic", "pH", "and", "subsequently", "washed", "led", "to", "successful", "T", "cell", "activation", "." ]
[ 0, 0, 0, 7, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 6, 6, 0, 0, 7, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
370
[ "We", "further", "demonstrate", "that", "TNF-alpha-", "and", "calyculin", "A-induced", "I", "kappa", "B", "alpha", "degradation", "exhibits", "similar", "but", "not", "identical", "sensitivities", "to", "a", "proteasome", "inhibitor", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
12455
[ "The", "levels", "of", "ICAM-1", "mRNA", "expression", "of", "ATL", "cells", "were", "generally", "higher", "than", "those", "of", "T-lymphoid", "cells", "." ]
[ 0, 0, 0, 3, 4, 0, 0, 5, 6, 0, 0, 0, 0, 0, 0, 7, 8, 0 ]
5558
[ "The", "mechanism", "of", "this", "effect", "is", "that", "Bcl-2", "prevents", "the", "nuclear", "translocation", "of", "NFAT", "(", "nuclear", "factor", "of", "activated", "T", "lymphocytes", ",", "a", "transcription", "factor", "activated", "by", "microtubule", "damage", ")", "by", "binding", "and", "sequestering", "calcineurin", ",", "a", "calcium-dependent", "phosphatase", "that", "must", "dephosphorylate", "NFAT", "to", "move", "to", "the", "nucleus", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 9, 0, 9, 10, 10, 10, 10, 10, 0, 0, 9, 10, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0 ]
13366
[ "Examination", "of", "IkappaB", "alpha", "regulation", "revealed", "that", "TNF-alpha", "-mediated", "degradation", "of", "IkappaB", "alpha", "in", "both", "memory", "and", "naive", "T", "cells", "from", "the", "elderly", "was", "severely", "impaired", ",", "thus", "contributing", "to", "the", "lowered", "induction", "of", "the", "observed", "NFkappaB", "." ]
[ 0, 0, 9, 10, 0, 0, 0, 9, 0, 0, 0, 9, 10, 0, 0, 7, 8, 8, 8, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0 ]
3964
[ "Upon", "recurrence", ",", "however", ",", "the", "tumors", "sustained", "either", "deletion", "of", "p16", "alone", "or", "codeletion", "of", "both", "p16", "and", "p15", "or", "amplification", "of", "CDK4", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 9, 0, 9, 0, 0, 0, 9, 0 ]
5020
[ "It", "remains", "open", "whether", "the", "growth", "retarding", "property", "of", "the", "EBNA2-oestrogen", "receptor", "fusion", "protein", "in", "B", "cell", "lymphoma", "lines", "is", "due", "to", "unphysiologically", "high", "expression", "of", "the", "chimeric", "protein", "or", "to", "interference", "with", "a", "cellular", "programme", "driving", "proliferation", "in", "these", "cell", "lines", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 0, 5, 6, 6, 6, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 6, 0 ]
8881
[ "Inhibition", "of", "NF-kappaB", "activity", "in", "a", "T", "cell", "hybridoma", "leads", "to", "decreased", "FasL", "expression", "and", "apoptosis", "upon", "T", "cell", "receptor", "stimulation", "." ]
[ 0, 0, 9, 0, 0, 0, 5, 6, 6, 0, 0, 0, 9, 0, 0, 0, 0, 9, 10, 10, 0, 0 ]
15491
[ "During", "the", "inflammatory", "response", "increased", "levels", "of", "PGE2", "bind", "to", "their", "receptors", "on", "T", "cells", "and", "thus", "alter", "responsiveness", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0, 0, 0, 0, 0 ]
5041
[ "To", "achieve", "a", "better", "understanding", "of", "the", "mechanism", "of", "transactivation", "by", "Tax", "of", "human", "T-cell", "leukemia", "virus", "type", "1", "Tax-responsive", "element", "1", "(", "TRE-1", ")", ",", "we", "developed", "a", "genetic", "approach", "with", "Saccharomyces", "cerevisiae", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
120
[ "Positive", "and", "negative", "regulation", "of", "granulocyte-macrophage", "colony-stimulating", "factor", "promoter", "activity", "by", "AML1-related", "transcription", "factor", ",", "PEBP2", "." ]
[ 0, 0, 0, 0, 0, 9, 10, 10, 0, 0, 0, 9, 10, 10, 0, 9, 0 ]
7948
[ "This", "study", "demonstrates", "that", "changes", "in", "endothelial", "cell", "GSSG/GSH", "cause", "transcription-independent", "and", "transcription-dependent", "surface", "expression", "of", "different", "endothelial", "cell", "adhesion", "molecules", ",", "which", "leads", "to", "a", "2-phase", "neutrophil", "-endothelial", "adhesion", "response", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 0, 0, 0, 0, 0, 0, 7, 0, 0, 0, 0 ]
1993
[ "The", "RAR", "alpha", "rearranged", "band", "in", "the", "Southern", "blot", "analysis", "and", "a", "chimaeric", "product", "of", "PML-RAR", "alpha", "by", "polymerase", "chain", "reaction", "were", "strongly", "visible", "before", "ATRA", "treatment", ",", "but", "at", "the", "time", "of", "maximal", "basophilia", "both", "of", "them", "were", "markedly", "diminished", "." ]
[ 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
6159
[ "Anaerobic", "threshold", "(", "AT", ")", "was", "determined", "from", "the", "point", "of", "departure", "of", "the", "ventilatory", "response", "from", "linearity", "and", "from", "the", "sudden", "increase", "in", "venous", "blood", "lactate", "concentrations", "during", "MPE", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
16747
[ "Virus", "stocks", "obtained", "from", "these", "experiments", "exhibited", "a", "continuum", "of", "replicative", "capacities", "in", "different", "human", "T-cell", "types", "depending", "on", "which", "element", "(", "s", ")", "was", "present", "in", "the", "LTR", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 8, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 1, 0 ]
155
[ "Erythropoietin", "stimulates", "transcription", "of", "the", "TAL1/SCL", "gene", "and", "phosphorylation", "of", "its", "protein", "products", "." ]
[ 9, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 9, 10, 0 ]
15524
[ "It", "is", "suggested", "that", "danazol", "has", "an", "anti-estrogenic", "action", "to", "the", "monocytes", "through", "the", "competition", "and", "suppression", "of", "estrogen", "binding", "sites", "as", "seen", "in", "the", "estrogen", "target", "organ", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
16464
[ "Furthermore", ",", "our", "results", "indicated", "that", "thymocytes", "have", "a", "constitutively", "active", "form", "of", "NF-kB", ",", "suggesting", "that", "they", "are", "activated", "in", "vivo", "." ]
[ 0, 0, 0, 0, 0, 0, 7, 0, 0, 9, 10, 10, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
14736
[ "All", "of", "the", "radiation-induced", "signals", "were", "effectively", "prevented", "by", "the", "protein-tyrosine", "kinase", "inhibitors", "genistein", "and", "herbimycin", "A", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 10, 10, 10, 0 ]
16694
[ "When", "the", "homeodomain", "from", "HB24", "was", "compared", "to", "known", "mammalian", "and", "Drosophila", "homeodomains", "it", "was", "found", "to", "be", "only", "moderately", "conserved", ",", "but", "when", "it", "was", "compared", "to", "a", "highly", "diverged", "Drosophila", "homeodomain", ",", "H2.0", ",", "it", "was", "found", "to", "be", "80", "%", "identical", "." ]
[ 0, 0, 1, 0, 1, 0, 0, 0, 0, 1, 2, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
17015
[ "This", "inhibitor", "did", "not", "affect", "protein", "kinase", "C", "-mediated", "gene", "transcription", ",", "suggesting", "that", "cyclic", "AMP-dependent", "protein", "kinases", "are", "involved", "in", "the", "signal", "transduction", "pathway", "for", "IL-1", "in", "a", "number", "of", "responsive", "cell", "types", "." ]
[ 0, 0, 0, 0, 0, 9, 10, 10, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 7, 8, 8, 0 ]
11753
[ "We", "demonstrate", "that", "upon", "stimulation", "by", "lipopolysaccharide", ",", "Taxol", ",", "phorbol", "myristate", "acetate", ",", "interleukin-1", ",", "or", "double-stranded", "RNA", ",", "I", "kappaB", "alpha", "is", "not", "degraded", ",", "as", "a", "result", "of", "an", "absence", "of", "induced", "phosphorylation", "on", "serines", "32", "and", "36", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 3, 4, 0, 9, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
13430
[ "The", "transcription", "factors", "c-myb", "and", "C/EBP", "alpha", "regulate", "the", "monocytic/myeloic", "gene", "MRP14", "." ]
[ 0, 9, 10, 9, 0, 9, 10, 0, 0, 1, 2, 1, 0 ]
12217
[ "Following", "EBV", "infection", ",", "Epstein-Barr", "nuclear", "antigen", "(", "EBNA", ")", "expression", "could", "be", "detected", "in", "T", "rosetting", "CD4+", "and", "CD8+", "T", "lymphocytes", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 7, 8, 8, 8, 8, 8, 8, 0 ]