id
stringlengths
1
5
tokens
sequence
ner_tags
sequence
3026
[ "Glucocorticoids", "(", "GCS", ")", "profoundly", "inhibit", "several", "aspects", "of", "T", "cell", "immunity", "largely", "through", "inhibition", "of", "cytokine", "expression", "at", "the", "transcriptional", "and", "posttranscriptional", "levels", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0 ]
15757
[ "Corticosteroids", "are", "the", "preeminent", "antiinflammatory", "agents", "although", "the", "molecular", "mechanisms", "that", "impart", "their", "efficacy", "have", "not", "been", "defined", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
6335
[ "Selenium-mediated", "inhibition", "of", "transcription", "factor", "NF-kappa", "B", "and", "HIV-1", "LTR", "promoter", "activity", "." ]
[ 0, 0, 0, 9, 10, 10, 10, 0, 1, 2, 2, 0, 0 ]
8701
[ "Surprisingly", ",", "overexpression", "of", "GRbeta", "in", "Jurkat", "cells", "did", "not", "cause", "significant", "inhibition", "of", "GRalpha", "-induced", "transactivation", "of", "a", "GRE-dependent", "luciferase", "reporter", "gene", "either", "." ]
[ 0, 0, 0, 0, 9, 0, 5, 6, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 1, 2, 2, 2, 0, 0 ]
17037
[ "Lymphocyte", "cell", "lines", "were", "established", "from", "five", "patients", "with", "vitamin", "D-dependent", "rickets", ",", "type", "II", "(", "VDDR-II", ")", "." ]
[ 5, 6, 6, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
11013
[ "These", "findings", "correlated", "with", "activation", "of", "the", "IkappaBalpha", "gene", "and", "blockade", "of", "the", "nuclear", "translocation", "of", "NFkappaB", "in", "the", "xenotransplanted", "tissue", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0 ]
15046
[ "However", ",", "Nef", "does", "not", "affect", "the", "DNA-binding", "activity", "of", "other", "transcription", "factors", "implicated", "in", "HIV-1", "regulation", ",", "including", "SP-1", ",", "USF", ",", "URS", ",", "and", "NF-AT", "." ]
[ 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 9, 0, 9, 0, 9, 0, 0, 9, 0 ]
9127
[ "Adhesion", "of", "monocytoid", "U937", "cells", "to", "LPS-treated", "endothelial", "cells", "was", "reduced", "concomitantly", "." ]
[ 0, 0, 5, 6, 6, 0, 0, 0, 0, 0, 0, 0, 0 ]
600
[ "We", "have", "identified", "an", "in", "vivo", "footprint", "over", "the", "PuF", "site", "on", "the", "translocated", "c-myc", "allele", "in", "Burkitt", "'s", "lymphoma", "cells", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0 ]
8897
[ "A", "Taq", "I", "polymorphism", "was", "identified", "which", "enabled", "chicken", "IL2", "to", "be", "mapped", "to", "chromosome", "4", ",", "linked", "to", "ANX5", ",", "with", "synteny", "with", "mouse", "chromosome", "3", "and", "human", "chromosome", "4", "." ]
[ 0, 1, 2, 2, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 1, 2, 0, 0, 0, 1, 0, 0, 0, 0, 1, 2, 2, 0, 1, 2, 2, 0 ]
2812
[ "Those", "cytokines", "may", "modulate", "the", "differentiation", "of", "monocytes", "by", "CSFs", "." ]
[ 0, 9, 0, 0, 0, 0, 0, 7, 0, 9, 0 ]
2457
[ "Thrombin", "and", "TRP", "also", "caused", "translocation", "of", "protein", "kinase", "C", "from", "the", "cytosol", "to", "the", "plasma", "membrane", "." ]
[ 9, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0 ]
14288
[ "Previously", ",", "we", "have", "reported", "that", "DHEA", "and", "synthetic", "analogs", "of", "DHEA", "can", "be", "modest", "inhibitors", "of", "HIV-1", "IIIB", "replication", "in", "phytohemagglutinin-stimulated", "peripheral", "blood", "lymphocyte", "cultures", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 6, 6, 6, 6, 0 ]
13056
[ "How", "important", "are", "the", "anti-inflammatory", "(", "non", "T", ")", "effects", "of", "CyA", ",", "and", "which", "cells", "do", "they", "operate", "in", "?" ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
3244
[ "When", "the", "promoter", "region", "was", "linked", "with", "a", "heterologous", "reporter", "gene", ",", "we", "found", "that", "the", "promoter", "region", "is", "inducible", "by", "both", "interferons", "(", "interferon-alpha", "and", "-gamma", ")", "and", "interferon", "regulatory", "factor", "1", "." ]
[ 0, 0, 1, 2, 0, 0, 0, 0, 1, 2, 2, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 9, 0, 9, 10, 10, 0, 0, 9, 10, 10, 10, 0 ]
17990
[ "Estrogen", "receptor", "concentration", "and", "social", "factors", "as", "predictors", "of", "natural", "killer", "cell", "activity", "in", "early-stage", "breast", "cancer", "patients", "." ]
[ 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
12612
[ "TPO", "is", "a", "hormone", "constitutively", "produced", "mainly", "by", "the", "liver", "and", "kidney", "." ]
[ 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
15601
[ "The", "mechanism", "of", "action", "of", "cyclosporin", "A", "and", "FK506", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
10584
[ "The", "strategy", "described", "here", "provides", "a", "new", "approach", "for", "studying", "protein-protein", "interactions", "that", "govern", "the", "complex", "regulation", "of", "gene", "expression", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
5266
[ "Histologic", "examination", "showed", "an", "extensive", "inflammatory", "cell", "infiltration", "around", "the", "airways", ",", "with", "epithelial", "necrosis", "and", "an", "alveolar", "exudate", "that", "caused", "localized", "alveolar", "collapse", "in", "the", "infected", "areas", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
13757
[ "Uncoupling", "of", "nonreceptor", "tyrosine", "kinases", "from", "PLC-gamma1", "in", "an", "SLP-76-deficient", "T", "cell", "." ]
[ 0, 0, 0, 9, 10, 0, 9, 0, 0, 0, 0, 0, 0 ]
2511
[ "However", ",", "all", "20", "cases", "lacked", "the", "t", "(", "15", ";", "17", ")", "and", "17", "cases", "tested", "lacked", "the", "promyelocytic/retinoic", "acid", "receptor", "alpha", "(", "RAR", "alpha", ")", "fusion", "transcript", "in", "RT-PCR", "assays", ";", "12", "cases", "had", "46", ",", "XX", "or", "46", ",", "XY", "karyotypes", ",", "whereas", "2", "cases", "had", "abnormalities", "of", "chromosome", "17q", ":", "1", "with", "del", "(", "17", ")", "(", "q25", ")", "and", "the", "other", "with", "t", "(", "11", ";", "17", ")", "(", "q23", ";", "q21", ")", "and", "the", "promyelocytic", "leukemia", "zinc", "finger/RAR", "alpha", "fusion", "transcript", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 4, 4, 4, 4, 4, 4, 4, 4, 4, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 1, 2, 2, 2, 2, 2, 2, 0, 0, 0, 0, 1, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 0, 0, 3, 4, 4, 4, 4, 4, 4, 0 ]
5870
[ "Here", "we", "demonstrate", "the", "binding", "of", "NFATp", "from", "lysates", "of", "T", "cells", "to", "immobilized", "calcineurin", "." ]
[ 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 7, 8, 0, 0, 9, 0 ]
15303
[ "Differential", "binding", "affinities", "were", "also", "obtained", "with", "p50-", "and", "c-Rel-selected", "sequences", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 2, 0 ]
11662
[ "During", "the", "course", "of", "serious", "bacterial", "infections", ",", "lipopolysaccharide", "(", "LPS", ")", "interacts", "with", "monocyte/macrophage", "receptors", ",", "resulting", "in", "the", "generation", "of", "inflammatory", "cytokines", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 9, 10, 0 ]
1985
[ "The", "approximate", "locations", "of", "the", "HSV-2", "genes", "encoding", "HSV-2", "type-specific", "CD4+", "antigens", "have", "been", "determined", "by", "using", "HSV-1", "x", "HSV-2", "intertypic", "recombinant", "virus", "and", "include", "the", "approximate", "map", "regions", "0.30", "to", "0.46", ",", "0.59", "to", "0.67", ",", "0.67", "to", "0.73", ",", "and", "0.82", "to", "1.0", "units", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
12902
[ "Progesterone", "acts", "distally", "to", "the", "initial", "steps", "of", "T", "cell", "receptor", "(", "TCR", ")", "-mediated", "signal", "transduction", ",", "since", "it", "blocks", "sustained", "Ca2+", "signals", "after", "thapsigargin", "stimulation", ",", "as", "well", "as", "oscillatory", "Ca2+", "signals", ",", "but", "not", "the", "Ca2+", "transient", "after", "TCR", "stimulation", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0 ]
9760
[ "Furthermore", ",", "we", "investigated", "the", "processes", "involved", "in", "persistent", "activation", "of", "NF-kappa", "B", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0 ]
9481
[ "Cyclosporin", "A", "inhibits", "early", "mRNA", "expression", "of", "G0/G1", "switch", "gene", "2", "(", "G0S2", ")", "in", "cultured", "human", "blood", "mononuclear", "cells", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 2, 0, 1, 0, 0, 5, 6, 6, 6, 6, 0 ]
10257
[ "Furthermore", ",", "prolonged", "degradation", "of", "IkappaB-alpha", "and", "activation", "of", "NF-kappaB", "were", "demonstrated", "in", "THP-1", "cells", "exposed", "to", "anti-E.", "chaffeensis", "serum", "and", "E.", "chaffeensis", "." ]
[ 0, 0, 0, 0, 0, 9, 0, 0, 0, 9, 0, 0, 0, 5, 6, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
5307
[ "Although", "there", "have", "been", "a", "number", "of", "reports", "demonstrating", "that", "glucocorticoids", "(", "in", "particular", "dexamethasone", ")", "antagonize", "the", "eosinophil", "life-prolonging", "effects", "of", "hemopoietins", ",", "direct", "effects", "of", "dexamethasone", "on", "eosinophil", "apoptosis", "have", "not", "been", "documented", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
9622
[ "Glucocorticoids", "and", "the", "immune", "function", "in", "the", "human", "immunodeficiency", "virus", "infection", ":", "a", "study", "in", "hypercortisolemic", "and", "cortisol-resistant", "patients", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
7371
[ "A", "PMA", "responsive", "element", "was", "localized", "to", "a", "region", "between", "-319", "and", "-219", "bp", "upstream", "of", "the", "initiation", "codon", "and", "co-transfections", "with", "transcription", "factor", "expression", "plasmids", "for", "AP-2", "and", "Sp1", "resulted", "in", "augmented", "ASM", "promoter", "activity", ",", "which", "was", "abolished", "when", "the", "binding", "sites", "for", "these", "two", "factors", "were", "deleted", "." ]
[ 0, 1, 2, 2, 0, 0, 0, 0, 0, 0, 1, 2, 2, 2, 2, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 2, 0, 9, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0 ]
17512
[ "(", "iv", ")", "No", "other", "EBV", "genes", "were", "required", "for", "EBNA-2", "transactivation", "of", "LMP1", "since", "cotransfection", "of", "recombinant", "EBNA-2", "expression", "vectors", "and", "genomic", "LMP1", "DNA", "fragments", "enhanced", "LMP1", "expression", "in", "the", "EBV-negative", "B-lymphoma", "cell", "lines", "BJAB", ",", "Louckes", ",", "and", "BL30", "." ]
[ 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 9, 0, 0, 9, 0, 0, 0, 1, 2, 2, 2, 0, 0, 1, 2, 2, 0, 9, 0, 0, 0, 5, 6, 6, 6, 5, 0, 5, 0, 0, 5, 0 ]
9
[ "HIV-1", "and", "HIV-2", "display", "significant", "differences", "in", "nucleic", "acid", "sequence", "and", "in", "the", "natural", "history", "of", "clinical", "disease", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
14427
[ "Phorbol", "ester", "and", "tumor", "necrosis", "factor-alpha", "induction", "of", "nuclear", "NF-kappa", "B", "is", "associated", "with", "both", "the", "degradation", "of", "performed", "I", "kappa", "B", "alpha", "and", "the", "activation", "of", "I", "kappa", "B", "alpha", "gene", "expression", "." ]
[ 0, 0, 0, 9, 10, 10, 0, 0, 9, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 0, 0, 0, 0, 9, 10, 10, 0, 0, 0, 0 ]
11319
[ "These", "results", "provide", "evidence", "that", "AML1", "proteins", "play", "a", "role", "in", "erythroid", "and", "megakaryocytic", "differentiation", "." ]
[ 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
16961
[ "Absent", "or", "greatly", "diminished", "type", "I", "aldosterone", "receptors", "in", "peripheral", "mononuclear", "leucocytes", "have", "been", "recently", "demonstrated", "and", "explain", "the", "lack", "of", "response", "to", "mineralocorticoids", "." ]
[ 0, 0, 0, 0, 0, 9, 10, 10, 0, 7, 8, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
11451
[ "All", "cases", "of", "follicular", ",", "mixed", "small", "and", "large", "cell", "lymphomas", "showed", "LAZ3/BCL6", "expression", "confined", "to", "the", "neoplastic", "follicles", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0 ]
1586
[ "Growth", "arrest", "occurred", "at", "G1", "and", "G2", "stages", "of", "the", "cell", "cycle", ",", "indicating", "that", "functional", "EBNA2", "is", "required", "at", "different", "restriction", "points", "of", "the", "cell", "cycle", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
17974
[ "Transient", "expression", "of", "CD69", "promoter-based", "reporter", "gene", "constructs", "in", "K562", "cells", "indicated", "that", "the", "proximal", "promoter", "region", "spanning", "positions", "-78", "to", "+16", "contained", "the", "cis-acting", "sequences", "necessary", "for", "basal", "and", "phorbol", "12-myristate", "13-acetate-inducible", "transcription", "of", "the", "CD69", "gene", "." ]
[ 0, 0, 0, 1, 2, 2, 2, 2, 0, 5, 6, 0, 0, 0, 1, 2, 2, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0 ]
2705
[ "Electrophoretic", "mobility", "shift", "assays", "indicate", "that", "MS-2beta", "and", "MS-2gamma", "interact", "with", "nuclear", "factors", "that", "are", "induced", "during", "U937", "differentiation", "." ]
[ 0, 0, 0, 0, 0, 0, 9, 0, 9, 0, 0, 9, 10, 0, 0, 0, 0, 5, 0, 0 ]
10341
[ "ZEB", ",", "a", "vertebrate", "homolog", "of", "Zfh-1", ",", "binds", "a", "subset", "of", "E", "boxes", "and", "blocks", "myogenesis", "through", "transcriptional", "repression", "of", "muscle", "genes", "." ]
[ 9, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0 ]
7229
[ "Although", "a", "substantial", "amount", "is", "known", "about", "the", "cellular", "elements", "that", "compose", "the", "lymphoid", "and", "nonlymphoid", "components", "of", "the", "secondary", "lymphoid", "tissues", ",", "information", "concerning", "the", "signals", "that", "control", "the", "development", "of", "the", "tissues", "and", "that", "maintain", "the", "organized", "tissue", "microenvironment", "remain", "undefined", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
6314
[ "All", "bacterial", "pathogens", "produce", "lipoproteins", "(", "BLPs", ")", ",", "which", "trigger", "the", "innate", "immune", "response", "." ]
[ 0, 0, 0, 0, 9, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0 ]
17647
[ "Proteins", "exist", "in", "leukocytes", "able", "to", "modify", "GTP-binding", "protein", "function", "in", "this", "manner", ",", "and", "their", "activity", "may", "be", "regulated", "by", "signals", "generated", "on", "phagocyte", "stimulation", "." ]
[ 0, 0, 0, 7, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
11247
[ "Furthermore", ",", "the", "nuclear", "protein", "complexes", "binding", "the", "SRE", "motif", "induced", "in", "activated", "T", "cells", "of", "young", "and", "elderly", "subjects", "contained", "serum", "response", "factor", "and", "Elk-1", "pointing", "toward", "age-related", "defects", "in", "the", "activation", "of", "transcriptional", "regulatory", "proteins", "distinct", "from", "c-jun/AP-1", "." ]
[ 0, 0, 0, 9, 10, 10, 0, 0, 1, 2, 0, 0, 7, 8, 8, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 0, 9, 0 ]
17059
[ "Treatment", "of", "HL-60", "cells", "with", "both", "TPA", "and", "cycloheximide", "had", "no", "effect", "on", "the", "rates", "of", "c-jun", "transcription", "." ]
[ 0, 0, 5, 6, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0 ]
6266
[ "Although", "the", "mechanism", "of", "HIV-1", "activation", "with", "heat", "shock", "has", "not", "been", "fully", "elucidated", "yet", ",", "it", "is", "presumed", "PKC", "plays", "an", "important", "role", "in", "HIV-1", "activation", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0 ]
3424
[ "The", "viral", "transcriptional", "pattern", "similar", "to", "that", "of", "nasopharyngeal", "carcinoma", "and", "Hodgkin", "'s", "disease", "suggests", "that", "EBV", "can", "exploit", "common", "regulatory", "mechanisms", "for", "gene", "transcription", "in", "diverse", "host", "cell", "types", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
3162
[ "Here", "we", "demonstrate", "that", "both", "in", "vitro-translated", "PU.1", "and", "PU.1", "from", "nuclear", "extracts", "bind", "to", "a", "specific", "site", "in", "the", "M-CSF", "receptor", "promoter", "just", "upstream", "from", "the", "major", "transcription", "initiation", "site", "." ]
[ 0, 0, 0, 0, 0, 0, 9, 10, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 0, 0, 0, 0, 1, 2, 2, 2, 0 ]
4379
[ "Norepinephrine", "and", "epinephrine", "also", "suppressed", "IL-12", "production", "in", "a", "dose-dependent", "fashion", "and", "at", "physiological", "concentrations", ";", "both", "catecholamines", ",", "however", ",", "dose-dependently", "increased", "the", "production", "of", "IL-10", "." ]
[ 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0 ]
14596
[ "The", "NK-kappa", "B", "transcription", "factor", "complex", "is", "sequestered", "in", "the", "cytoplasm", "by", "the", "inhibitory", "protein", "I", "kappa", "B-alpha", "(", "MAD-3", ")", "." ]
[ 0, 9, 10, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 9, 0, 0 ]
11486
[ "To", "examine", "the", "factors", "controlling", "vascular-specific", "expression", "of", "PECAM-1", ",", "we", "cloned", "the", "5'-flanking", "region", "of", "the", "PECAM-1", "gene", "and", "analyzed", "its", "transcriptional", "activity", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 1, 2, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0 ]
5250
[ "In", "the", "nuclei", "of", "EBV-transformed", "lymphoblastoid", "cell", "lines", "EBNA-5", "is", "preferentially", "targetted", "to", "distinct", "nuclear", "foci", "." ]
[ 0, 0, 0, 0, 5, 6, 6, 6, 9, 0, 0, 0, 0, 0, 0, 0, 0 ]
17857
[ "Cloning", "a", "cDNA", "from", "human", "NK/T", "cells", "which", "codes", "for", "a", "protein", "with", "high", "proline", "content", "." ]
[ 0, 0, 1, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
1610
[ "This", "role", "for", "c-Myc", "in", "apoptosis", "is", "now", "confirmed", "in", "studies", "using", "a", "dominant", "negative", "form", "of", "its", "heterodimeric", "binding", "partner", ",", "Max", ",", "which", "we", "show", "here", "inhibits", "activation-induced", "apoptosis", "." ]
[ 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
15487
[ "1", "." ]
[ 0, 0 ]
12292
[ "Nuclear", "extracts", "of", "anti-", "CD15", "cross-linked", "cells", "demonstrated", "enhanced", "levels", "of", "the", "transcriptional", "factor", "activator", "protein-1", ",", "minimally", "changed", "nuclear", "factor-kappa", "B", ",", "and", "did", "not", "affect", "SV40", "promoter", "specific", "protein-1", "." ]
[ 0, 0, 0, 0, 7, 8, 8, 0, 0, 0, 0, 0, 9, 10, 10, 10, 0, 0, 0, 9, 10, 10, 0, 0, 0, 0, 0, 9, 10, 10, 10, 0 ]
5338
[ "The", "CD28RE", "sequence", "reveals", "similarity", "to", "the", "consensus", "kappaB", "binding", "motif", "." ]
[ 0, 1, 0, 0, 0, 0, 0, 1, 2, 2, 2, 0 ]
587
[ "Circumvention", "of", "tolerance", "for", "the", "nuclear", "T", "cell", "protein", "TCF-1", "by", "immunization", "of", "TCF-1", "knock-out", "mice", "." ]
[ 0, 0, 0, 0, 0, 9, 10, 10, 10, 9, 0, 0, 0, 9, 0, 0, 0 ]
12407
[ "IL-10", "pretreatment", "prevented", "LPS-induced", "decreases", "in", "IkappaB-alpha", "protein", "levels", "and", "attenuated", "NF-kappaB", "DNA", "binding", "." ]
[ 9, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 9, 0, 0, 0 ]
1865
[ "Only", "partial", "receptor", "occupancy", "accompanied", "complete", "lymphocyte", "suppression", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
15249
[ "Stronger", "c-myc", "mRNA", "expression", "was", "detected", "in", "labial", "salivary", "glands", "of", "patients", "with", "longer", "disease", "duration", "(", "p", "less", "than", "or", "equal", "to", "0.002", ")", "and", "more", "intense", "T", "lymphocyte", "infiltrates", "(", "p", "less", "than", "0.05", ")", "although", "these", "patients", "revealed", "no", "hypergammaglobulinemia", "." ]
[ 0, 3, 4, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
15090
[ "Furthermore", ",", "we", "evaluated", "the", "mineralocorticoid", "receptor", "(", "MR", ")", "status", "in", "mononuclear", "leukocytes", "in", "the", "2", "groups", "." ]
[ 0, 0, 0, 0, 0, 9, 10, 0, 9, 0, 0, 0, 7, 8, 0, 0, 0, 0, 0 ]
14314
[ "We", "have", "demonstrated", "earlier", "that", "the", "crosslinkage", "of", "the", "CD3/TCR", "complex", "with", "the", "CD2", "antigen", "results", "in", "the", "proliferation", "of", "normal", "human", "T", "cells", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 9, 10, 0, 0, 0, 0, 0, 7, 8, 8, 8, 0 ]
5182
[ "Western", "Blot", "analysis", "using", "antibodies", "against", "subunits", "of", "GTP-binding", "proteins", "indicated", "that", "Gq/G11", "richly", "existed", "in", "Jurkat", "cells", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 9, 0, 0, 0, 5, 6, 0 ]
1065
[ "As", "such", ",", "these", "data", "suggest", "that", "different", "proximal", "mechanisms", "may", "lead", "to", "restricted", "HIV-1", "replication", "in", "various", "cell", "types", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
10176
[ "Sequential", "development", "of", "structural", "and", "functional", "alterations", "in", "T", "cells", "from", "tumor-bearing", "mice", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0, 0, 0, 0 ]
2675
[ "This", "phenomenon", "is", "correlated", "with", "inhibition", "of", "GATA1", "induction", "in", "the", "early", "stages", "of", "erythropoietic", "differentiation", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
2590
[ "LPS-stimulated", "translocation", "of", "NF-kappa", "B", "in", "CHO/CD14", "cells", "resembled", "the", "same", "response", "in", "the", "murine", "macrophage-like", "cell", "line", "RAW", "264.7", "." ]
[ 0, 0, 0, 9, 10, 0, 5, 6, 0, 0, 0, 0, 0, 0, 5, 6, 6, 6, 5, 6, 0 ]
13429
[ "We", "conclude", "that", "although", "cell", "cycle", "arrest", "induced", "by", "alpha-IFN", "may", "be", "mediated", "in", "part", "by", "formation", "of", "a", "complex", "containing", "p130", "and", "E2F-4", ",", "alpha-IFN", "does", "not", "induce", "hyperphosphorylation", "of", "E2F-4", ",", "which", "characterizes", "primary", "hemopoietic", "cells", "in", "G0", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 9, 0, 9, 0, 0, 0, 0, 0, 9, 0, 0, 0, 7, 8, 8, 0, 0, 0 ]
5244
[ "Ca2+-modulating", "cyclophilin", "ligand", "(", "CAML", ")", "was", "originally", "described", "as", "a", "cyclophilin", "B-binding", "protein", "whose", "overexpression", "in", "T", "cells", "causes", "a", "rise", "in", "intracellular", "calcium", ",", "thus", "activating", "transcription", "factors", "responsible", "for", "the", "early", "immune", "response", "." ]
[ 9, 10, 10, 0, 9, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0 ]
15848
[ "TAR", "-independent", "transactivation", "by", "Tat", "in", "cells", "derived", "from", "the", "CNS", ":", "a", "novel", "mechanism", "of", "HIV-1", "gene", "regulation", "." ]
[ 1, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
10769
[ "Cyclin", "A", "was", "observed", "after", "4", "days", "of", "costimulation", "with", "anti", "CD2", "+", "CD28", "whereas", "stimulation", "by", "anti", "CD2", "or", "anti", "CD28", "alone", "was", "not", "effective", "." ]
[ 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 9, 0, 0, 0, 9, 10, 0, 9, 10, 0, 0, 0, 0, 0 ]
7315
[ "Moreover", ",", "anti-", "STAT3", "antibodies", "specifically", "precipitated", "a", "protein", "of", "92", "kDa", "that", "becomes", "phosphorylated", "on", "tyrosine", "upon", "lymphocyte", "treatment", "with", "H2O2", "." ]
[ 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
12087
[ "Taken", "together", "these", "data", "indicate", "that", "carboxylesterase", "gene", "transcription", "in", "THP-1", "cells", "starts", "at", "multiple", "initiation", "sites", "and", "that", "Sp1", "and", "IRBP", "may", "be", "critical", "factors", "for", "modulating", "the", "differentiation-dependent", "transcription", "of", "this", "human", "carboxylesterase", "gene", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 6, 0, 0, 0, 0, 0, 0, 0, 9, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 0 ]
3217
[ "DR3", "signal", "transduction", "is", "mediated", "by", "a", "complex", "of", "intracellular", "signaling", "molecules", "including", "TRADD", ",", "TRAF2", ",", "FADD", ",", "and", "FLICE", "." ]
[ 9, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 9, 0, 9, 0, 9, 0, 0, 9, 0 ]
17986
[ "Thromboxane", "receptor", "promoter", "activity", ",", "as", "assessed", "by", "CAT", "expression", ",", "was", "relatively", "weak", "but", "was", "significantly", "enhanced", "by", "phorbol", "ester", "treatment", "." ]
[ 0, 1, 2, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
13122
[ "LMP1", "contains", "two", "domains", "that", "activate", "the", "transcription", "factor", "NF-kappaB", ",", "one", "through", "interactions", "with", "TRAF", "proteins", "and", "the", "other", "with", "the", "TRADD", "protein", "." ]
[ 9, 0, 0, 0, 0, 0, 0, 9, 10, 9, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 9, 10, 0 ]
486
[ "In", "this", "report", ",", "we", "show", "that", "in", "monocytes", "and", "T", "cells", "IL-10", "stimulates", "tyrosine", "phosphorylation", "of", "the", "signal", "transducers", "and", "activators", "of", "transcription", ",", "STAT1", "alpha", "and", "STAT3", ",", "in", "a", "differential", "manner", "such", "that", "the", "relative", "formation", "of", "homo-", "and", "heterodimers", "varies", "between", "the", "two", "cell", "types", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 7, 0, 7, 8, 9, 0, 0, 0, 0, 0, 9, 10, 0, 9, 10, 10, 0, 9, 10, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 0, 0, 0, 0, 0, 0 ]
3814
[ "AP-1", "has", "been", "shown", "to", "behave", "as", "a", "redox-sensitive", "transcription", "factor", "that", "can", "be", "activated", "by", "both", "oxidant", "and", "antioxidant", "stimuli", "." ]
[ 9, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
10172
[ "We", "show", "that", "in", "parental", "K562", "cells", ",", "the", "HSF2-alpha", "isoform", "is", "predominantly", "expressed", "and", "HSF2", "can", "be", "activated", "upon", "hemin", "treatment", "." ]
[ 0, 0, 0, 0, 0, 5, 6, 0, 0, 9, 10, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0 ]
7427
[ "Importantly", ",", "it", "was", "also", "present", "in", "the", "nucleus", "of", "HeLa", "cells", ",", "which", "lack", "HNF1", ",", "and", "in", "the", "cytoplasm", "of", "fibroblasts", "that", "have", "little", "or", "no", "tetrahydrobiopterin", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 6, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 7, 0, 0, 0, 0, 0, 9, 0 ]
8925
[ "IL-12", "induced", "STAT4", "and", "IL-2", "and", "IL-15", "induced", "STAT5", "binding", "to", "the", "GAS", "elements", "." ]
[ 9, 0, 9, 0, 9, 0, 9, 0, 9, 0, 0, 0, 1, 2, 0 ]
18213
[ "As", "this", "phosphorylation", "was", "independent", "of", "protein", "kinase", "C", "activity", ",", "we", "tested", "whether", "a", "calcium/calmodulin-dependent", "protein", "kinase", "(", "CaM", "kinase", ")", "might", "phosphorylate", "the", "Ets-1", "protein", "after", "elevation", "of", "intracellular", "free", "calcium", "concentrations", "." ]
[ 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 9, 10, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0 ]
2418
[ "All-trans", "retinoic", "acid", "(", "RA", ")", "induces", "differentiation", "of", "HL60", "cells", "to", "neutrophils", "and", "is", "used", "to", "treat", "acute", "promyelocytic", "leukemia", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 6, 0, 7, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
10767
[ "To", "understand", "the", "mechanisms", "underlined", "in", "this", "regulation", "in", "normal", "human", "cells", ",", "we", "have", "analysed", "in", "vivo", "protein-DNA", "interactions", "at", "the", "Cyclin", "A", "locus", "in", "primary", "T", "lymphocytes", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 7, 8, 8, 0 ]
17032
[ "The", "results", "showed", "that", "in", "hyper-", "and", "hypothyroid", "patients", "the", "nuclear", "affinity", "(", "Ka", ")", "for", "T3", "was", "similar", "to", "that", "of", "normal", "subjects", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
16187
[ "A", "total", "of", "37", "chronic", ",", "severe", ",", "nonsmoking", "asthmatic", "patients", "with", "documented", "reversible", "airways", "obstruction", "were", "classified", "as", "glucocorticoid-sensitive", "or", "-resistant", "on", "the", "basis", "of", "changes", "in", "FEV1", ",", "FVC", ",", "and", "peak", "expiratory", "flow", "(", "PEF", ")", "after", "oral", "prednisolone", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
9663
[ "We", "have", "selected", "16", "sequences", "and", "confirmed", "their", "down-regulation", "along", "the", "TPA-induced", "monocytic", "differentiation", "of", "HL60", "cells", "." ]
[ 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 6, 0 ]
13711
[ "We", "studied", "the", "number", "of", "glucocorticoid", "receptors", "and", "dissociation", "constant", "in", "isolated", "human", "lymphocytes", "as", "well", "as", "blood", "concentrations", "of", "hormones", "produced", "by", "the", "hypothalamic-hypophyseal-adrenocortical", "system", "in", "three", "experimental", "series", ":", "at", "normal", "(", "17", "subjects", ")", ",", "decreased", "(", "10", "subjects", ",", "a", "360-d", "head-down", "bed", "rest", ")", "and", "increased", "(", "8", "subjects", ",", "physical", "exercise", "on", "bicycle", "ergometer", ")", "levels", "of", "motor", "activity", "." ]
[ 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 7, 8, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
5034
[ "To", "address", "this", "issue", ",", "we", "sought", "to", "utilize", "the", "nonhuman", "primate", "model", "to", "study", "intracellular", "signaling", "events", "in", "cells", "from", "disease-susceptible", "rhesus", "macaques", "and", "disease-resistant", "sooty", "mangabeys", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
3449
[ "The", "interleukin-2", "(", "IL-2", ")", "promoter", "consists", "of", "several", "independent", "T", "cell", "receptor", "(", "TcR", ")", "responsive", "elements", "." ]
[ 0, 1, 2, 2, 2, 2, 0, 0, 0, 0, 1, 2, 2, 2, 2, 2, 2, 2, 0 ]
9355
[ "A-myb", "is", "strongly", "expressed", "in", "Burkitt", "'s", "lymphomas", "(", "BL", ")", "and", "slg+", "B-acute", "lymphoblastic", "leukaemias", "(", "B-ALL", ")", "and", "not", "in", "all", "other", "leukaemias/lymphomas", "tested", ",", "with", "the", "exception", "of", "a", "subset", "of", "CLL", "(", "about", "25", "%", "of", "cases", ")", "." ]
[ 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
5667
[ "A", "reporter", "construct", "containing", "the", "5'-flanking", "region", "of", "the", "mouse", "TNF-alpha", "gene", "displayed", "weak", "activity", "when", "transfected", "into", "RAW264.7", "macrophage-like", "cells", "." ]
[ 0, 1, 2, 0, 0, 1, 2, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 5, 6, 6, 0 ]
18240
[ "Platelet", "glycoprotein", "(", "GP", ")", "Ib-IX-V", "is", "a", "multisubunit", "adhesion", "receptor", "that", "supports", "platelet", "attachment", "to", "thrombogenic", "surfaces", "at", "sites", "of", "vascular", "injury", "." ]
[ 9, 10, 0, 9, 0, 9, 0, 0, 9, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
7489
[ "Inhibition", "of", "T", "cell", "signaling", "by", "mitogen-activated", "protein", "kinase-targeted", "hematopoietic", "tyrosine", "phosphatase", "(", "HePTP", ")", "." ]
[ 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 10, 10, 0, 9, 0, 0 ]
10920
[ "Histamine", "modulates", "the", "expression", "of", "c-fos", "through", "cyclic", "AMP", "production", "via", "the", "H2", "receptor", "in", "the", "human", "promonocytic", "cell", "line", "U937", "." ]
[ 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 5, 6, 6, 6, 6, 0 ]
4493
[ "Therefore", ",", "activation", "of", "STAT5A", "predominates", "compared", "to", "STAT5B", "when", "assayed", "by", "direct", "immunoprecipitation", "and", "by", "evaluation", "of", "bound", "STATs", "to", "immobilized", "GRR", "." ]
[ 0, 0, 0, 0, 9, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 1, 0 ]