Datasets:

---

siddharthtumre

/

jnlpba-split

like 0

[ "Kinase", "activity", "was", "reduced", "in", "lysates", "preadsorbed", "using", "an", "antibody", "specific", "for", "CaM", "kinase", "II", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 9, 10, 10, 0 ]

[ "Furthermore", ",", "persistent", "HIV", "infection", "of", "monocytes", "and", "macrophages", "provides", "a", "useful", "model", "with", "which", "to", "study", "concomitant", "modifications", "of", "different", "I", "kappa", "B", "molecules", "." ]

[ 0, 0, 0, 0, 0, 0, 7, 0, 7, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 0 ]

[ "These", "results", "establish", "EKLF", "as", "a", "tissue-specific", "transcription", "factor", "that", "undergoes", "post-translational", "acetylation", "and", "suggest", "a", "mechanism", "by", "which", "EKLF", "is", "able", "to", "alter", "chromatin", "structure", "and", "induce", "beta-globin", "expression", "within", "the", "beta-like", "globin", "cluster", "." ]

[ 0, 0, 0, 9, 0, 0, 9, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 1, 0, 0, 0, 9, 0, 0, 0, 1, 2, 2, 0 ]

[ "Heparin", "is", "a", "polyanionic", "glycosaminoglycan", "(", "GAG", ")", "that", "can", "bind", "with", "high", "affinity", "to", "a", "range", "of", "cytokines", "including", "interferon-gamma", "(", "IFN-gamma", ")", "and", "members", "of", "the", "chemokine", "superfamily", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 9, 0, 9, 0, 0, 0, 0, 0, 9, 10, 0 ]

[ "Fos", "proteins", "are", "not", "needed", "for", "this", "reconstitution", ",", "and", "although", "JunB", "is", "not", "functional", ",", "it", "can", "participate", "in", "the", "NF-AT", "DNA", "binding", "complex", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 0 ]

[ "TNF-alpha", "was", "able", "to", "increase", "expression", "of", "the", "HIV", "LTR", "in", "T", "cells", ",", "but", "in", "monocytic", "cells", ",", "TNF-alpha", "did", "not", "induce", "the", "HIV", "LTR", "above", "a", "constitutive", "level", "of", "activity", "." ]

[ 9, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 7, 8, 0, 0, 0, 7, 8, 0, 9, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0 ]

[ "The", "CD19", "protein", "is", "expressed", "on", "the", "surface", "of", "all", "B-lymphoid", "cells", "with", "the", "exception", "of", "terminally", "differentiated", "plasma", "cells", "and", "has", "been", "implicated", "as", "a", "signal-transducing", "receptor", "in", "the", "control", "of", "proliferation", "and", "differentiation", "." ]

[ 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0, 0, 0, 0, 7, 8, 8, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Infection", "with", "Theileria", "annulata", "induces", "expression", "of", "matrix", "metalloproteinase", "9", "and", "transcription", "factor", "AP-1", "in", "bovine", "leucocytes", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 9, 10, 9, 0, 7, 8, 0 ]

[ "These", "results", "reveal", "that", "HSF3", "is", "negatively", "regulated", "in", "avian", "cells", "and", "acquires", "DNA-binding", "activity", "in", "certain", "cells", "upon", "heat", "shock", "." ]

[ 0, 0, 0, 0, 9, 0, 0, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "We", "have", "cloned", "the", "latent", "membrane", "protein", "1", "(", "LMP1", ")", "homologs", "from", "the", "simian", "EBV", "naturally", "infecting", "baboons", "(", "cercopithicine", "herpesvirus", "12", ",", "herpesvirus", "papio", ")", "and", "rhesus", "monkeys", "(", "cercopithicine", "herpesvirus", "15", ")", "for", "a", "comparative", "study", "with", "the", "human", "EBV", "oncogene", "." ]

[ 0, 0, 0, 0, 9, 10, 10, 10, 10, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Interaction", "between", "the", "stage", "selector", "element", "(", "SSE", ")", "in", "the", "proximal", "gamma-globin", "promoter", "and", "hypersensitivity", "site", "2", "in", "the", "locus", "control", "region", "partly", "mediates", "the", "competitive", "silencing", "of", "the", "beta-globin", "promoter", "in", "the", "fetal", "developmental", "stage", "." ]

[ 0, 0, 0, 1, 2, 2, 0, 0, 0, 0, 0, 1, 2, 2, 0, 1, 2, 2, 0, 0, 1, 2, 2, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0 ]

[ "The", "role", "of", "PtdIns", "3-kinase", "in", "Ras", "signaling", "in", "T", "cells", "has", "not", "been", "explored", "." ]

[ 0, 0, 0, 9, 10, 0, 9, 0, 0, 7, 8, 0, 0, 0, 0, 0 ]

[ "Using", "the", "technique", "of", "reverse", "transcription-polymerase", "chain", "reaction", "(", "PCR", ")", "with", "RNA", "isolated", "from", "lymphoid", "cell", "lines", "of", "the", "patient", "and", "of", "controls", ",", "no", "evidence", "was", "found", "that", "IVS1-10TC", "abnormally", "disrupted", "mRNA", "splicing", "or", "caused", "the", "absence", "of", "BRCA1", "mRNA", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 6, 6, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 0, 0, 0, 0, 0, 0, 3, 4, 0 ]

[ "In", "this", "report", "we", "describe", "how", "signals", "initiated", "through", "the", "type", "I", "IL-1R", "interact", "with", "signals", "from", "the", "antigen", "receptor", "to", "synergistically", "augment", "the", "transactivating", "properties", "of", "NF-kappa", "B", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0 ]

[ "Production", "of", "IL-2", "requires", "the", "formation", "of", "transcription", "factors", "involved", "in", "the", "IL-2-gene", "regulation", "." ]

[ 0, 0, 9, 0, 0, 0, 0, 9, 10, 0, 0, 0, 1, 0, 0 ]

[ "However", ",", "the", "events", "leading", "from", "the", "activated", "receptor", "to", "cell", "lysis", "are", "not", "understood", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Immunophenotype", "of", "intraductal", "carcinoma", "." ]

[ 0, 0, 0, 0, 0 ]

[ "The", "Sp1", "transcription", "factor", "bound", "to", "three", "different", "regions", "in", "the", "CD14", "promoter", "." ]

[ 0, 9, 9, 10, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0 ]

[ "This", "work", "aims", "at", "identifying", "the", "thymocyte", "subpopulation", "able", "to", "support", "human", "immunodeficiency", "virus", "(", "HIV", ")", "replication", "under", "the", "biological", "stimuli", "of", "the", "thymic", "microenvironment", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Lethality", "was", "associated", "with", "more", "severe", "leukopenia", "in", "transgenic", "versus", "control", "mice", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "The", "signal", "is", "subsequently", "propagated", "through", "the", "activation", "of", "Raf-1", ",", "MEK", ",", "and", "MAP", "kinases", "as", "shown", "by", "their", "increased", "autophosphorylation", "in", "vitro", "and", "phosphorylation", "in", "situ", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 9, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Using", "this", "antibody", ",", "we", "isolated", "and", "sequenced", "a", "human", "cDNA", "clone", "encoding", "a", "protein", "that", "was", "identical", "to", "the", "mammalian", "27-kDa", "heat", "shock", "protein", "(", "HSP27", ")", ",", "a", "protein", "of", "uncertain", "function", "that", "is", "known", "to", "be", "phosphorylated", "to", "several", "forms", "and", "to", "be", "transcriptionally", "induced", "by", "estrogen", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 10, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Therefore", ",", "monokine", "induction", "is", "a", "zinc-specific", "effect", "influenced", "by", "the", "physicochemical", "properties", "of", "the", "ion", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "A", "5.5-kilobase", "genomic", "clone", "contained", "the", "full-length", "CD14", "coding", "sequence", "and", "4.2", "kilobases", "of", "5'-upstream", "sequence", "." ]

[ 0, 1, 2, 2, 0, 0, 0, 1, 2, 2, 0, 1, 2, 2, 2, 2, 0 ]

[ "Because", "of", "cell", "type-specific", "alternative", "messenger", "RNA", "splicing", ",", "B-cell", "Fc", "gamma", "RII", "contains", "an", "insertion", "of", "47", "amino", "acids", "that", "participates", "in", "determining", "receptor", "function", "in", "these", "cells", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "We", "also", "examined", "the", "function", "of", "the", "IL-3", "CK-1/CK-2", "elements", "that", "are", "present", "in", "many", "cytokine", "genes", "and", "found", "that", "they", "acted", "as", "a", "repressor", "of", "basal", "level", "expression", "when", "cloned", "upstream", "of", "a", "heterologous", "promoter", "but", "were", "also", "inducible", "by", "PMA", "/PHA", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 9, 0 ]

[ "We", "show", "that", "PNU156804", "does", "not", "inhibit", "c-myc", "and", "bcl-2", "mRNA", "induction", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "A", "hydrophobic", "domain", "of", "Ca2+-modulating", "cyclophilin", "ligand", "modulates", "calcium", "influx", "signaling", "in", "T", "lymphocytes", "." ]

[ 0, 0, 0, 0, 9, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Various", "antioxidants", ",", "such", "as", "pyrrolidine", "dithiocarbamate", ",", "p-bromophenacyl-bromide", "and", "nordihydroguaiaretic", "acid", "could", "strongly", "reduce", "NF-kappaB", "translocation", ",", "demonstrating", "the", "importance", "of", "oxidative", "species", "in", "the", "transduction", "mechanism", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "For", "this", "purpose", ",", "we", "used", "three", "main", "approaches", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "All-trans", "retinoic", "acid", "(", "ATRA", ")", "is", "successfully", "used", "in", "the", "cyto-differentiating", "treatment", "of", "acute", "promyelocytic", "leukemia", "(", "APL", ")", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "The", "mechanism", "(", "s", ")", "of", "action", "of", "GCH", "is", "under", "investigation", ",", "but", "is", "has", "been", "noted", "that", "they", "exert", "immune", "activity", "via", "the", "genomic", "pathway", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Here", "we", "show", "that", "contrary", "to", "previous", "reports", ",", "PU.1", "and", "Spi-B", "have", "very", "different", "expression", "patterns", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 9, 0, 0, 0, 0, 0, 0 ]

[ "Two", "tyrosine", "phosphoproteins", "of", "38", "and", "63", "kD", "bind", "to", "the", "SH2", "domain", "of", "Grb2", "following", "Fc", "gamma", "RIIA", "stimulation", "of", "platelets", "." ]

[ 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 9, 0, 9, 10, 10, 0, 0, 7, 0 ]

[ "The", "resolution", "of", "immune", "responses", "is", "characterized", "by", "extensive", "apoptosis", "of", "activated", "T", "cells", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0 ]

[ "In", "contrast", ",", "formation", "of", "the", "B1", "complex", ",", "reflecting", "the", "binding", "of", "p75", "and", "p85", ",", "critically", "depends", "upon", "the", "more", "3", "'", "sequences", "of", "this", "enhancer", "element", "." ]

[ 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 9, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0 ]

[ "The", "TCR", "alpha", "beta", "or", "-gamma", "delta", "chains", "bind", "the", "peptide", "ligand", ",", "whereas", "the", "associated", "CD3", "delta", "epsilon", "gamma", "and", "TCR", "zeta", "subunits", "couple", "the", "TCR", "to", "intracellular", "signal", "transduction", "components", "." ]

[ 0, 9, 10, 10, 10, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 0, 9, 10, 10, 0, 0, 9, 0, 0, 0, 0, 0, 0 ]

[ "Signals", "leading", "to", "the", "activation", "of", "NF-kappa", "B", "transcription", "factor", "are", "stronger", "in", "neonatal", "than", "adult", "T", "lymphocytes", "." ]

[ 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 0, 0, 0, 7, 8, 8, 8, 8, 0 ]

[ "A", "DNA", "fragment", "containing", "128", "bp", "of", "upstream", "sequence", "had", "strong", ",", "monocyte-specific", "promoter", "activity", "in", "the", "CD14", "positive", "monocytic", "cell", "line", "Mono", "Mac", "6", "as", "compared", "to", "the", "nonmonocytic", "cell", "lines", "HeLa", "and", "REX", "." ]

[ 0, 1, 2, 0, 1, 2, 2, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0, 5, 6, 6, 6, 6, 5, 6, 6, 0, 0, 0, 0, 5, 6, 6, 5, 0, 5, 0 ]

[ "Delayed", "administration", "of", "rBPI21", "also", "affected", "LPS-mediated", "activation", "of", "the", "nuclear", "factor", ",", "NF-kappa", "B", "." ]

[ 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 9, 10, 0, 9, 10, 0 ]

[ "Granulocyte", "colony-stimulating", "factor", "activates", "a", "72-kDa", "isoform", "of", "STAT3", "in", "human", "neutrophils", "." ]

[ 9, 10, 10, 0, 0, 9, 10, 0, 9, 0, 7, 8, 0 ]

[ "Production", "of", "IL-8", "by", "hypoxic", "ECs", "occurred", "concomitantly", "with", "both", "increased", "levels", "of", "IL-8", "mRNA", ",", "based", "on", "polymerase", "chain", "reaction", "analysis", ",", "and", "increased", "IL-8", "transcription", ",", "based", "on", "nuclear", "run-on", "assays", "." ]

[ 0, 0, 9, 0, 0, 7, 0, 0, 0, 0, 0, 0, 0, 3, 4, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Our", "results", "strongly", "suggest", "that", "this", "NF-AT", "/DNA", "binding", "defect", "is", "responsible", "for", "the", "multiple", "cytokine", "deficiency", "and", "the", "SCID", "phenotype", "observed", "in", "the", "two", "infant", "brothers", "." ]

[ 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Using", "flow", "cytometry", ",", "we", "detected", "surrogate", "TG", "receptors", "on", "non-T", "(", "but", "not", "on", "T", ")", "cells", "from", "11", "of", "11", "individuals", "studied", "(", "5", "Hashimoto", "patients", "and", "6", "control", "donors", ")", "." ]

[ 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 7, 8, 8, 8, 8, 8, 8, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "The", "gp160-mediated", "activation", "of", "NF-kappa", "B", "in", "CD4", "positive", "T", "cells", "may", "be", "involved", "in", "biological", "effects", ",", "e.g.", ",", "enhanced", "HIV", "replication", ",", "hypergammaglobulinemia", ",", "increased", "cytokine", "secretion", ",", "hypercellularity", "in", "bone", "marrow", "and", "apoptosis", "." ]

[ 0, 0, 0, 0, 9, 10, 0, 7, 8, 8, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Induction", "of", "DNA", "binding", "activity", "was", "associated", "temporally", "with", "Epo", "-induced", "phosphorylation", "of", "nuclear", "TAL1", "protein", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 9, 10, 10, 0 ]

[ "In", "the", "locus", "control", "region", "(", "LCR", ")", "of", "the", "beta-globin", "locus", ",", "in", "vivo", "footprints", "on", "NF-E2", "(", "or", "AP-1", ")", "and", "GATA-1", "motifs", "remained", "the", "same", "regardless", "of", "whether", "the", "fetal", "or", "the", "adult", "globin", "genes", "are", "expressed", "." ]

[ 0, 0, 1, 2, 2, 0, 1, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 9, 0, 0, 9, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 0, 0, 0 ]

[ "This", "suppressive", "effect", "was", "also", "seen", "in", "IL-2", "-driven", "cell", "growth", "of", "CD8-positive", "lymphocytes", "purified", "from", "7-day", "PHA-blasts", ",", "indicating", "that", "CD4", "molecules", "were", "not", "required", "for", "the", "suppression", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 7, 8, 0, 0, 7, 8, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0 ]

[ "Proerythroblasts", "and", "megakaryocytes", "massively", "accumulated", "in", "the", "spleens", "of", "the", "heterozygotes", ",", "and", "we", "showed", "that", "the", "neomycin", "resistance", "gene", "(", "which", "is", "the", "positive", "selection", "marker", "in", "ES", "cells", ")", "was", "expressed", "profusely", "in", "the", "abnormally", "abundant", "cells", "generated", "in", "the", "GATA-1.05", "mutant", "females", "." ]

[ 7, 0, 7, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0 ]

[ "By", "comparison", ",", "an", "isotype-matched", "antibody", "had", "no", "effect", "on", "NF-kappa", "B", "activation", "." ]

[ 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 9, 10, 0, 0 ]

[ "Nitric", "oxide", "subserves", "diverse", "physiologic", "roles", "in", "the", "nervous", "system", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "The", "effect", "of", "dexamethasone", "on", "both", "cell", "types", "was", "mediated", "through", "the", "glucocorticoid", "receptor", ",", "i.e.", ",", "it", "was", "abolished", "by", "the", "glucocorticoid", "receptor", "antagonist", "RU38486", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0 ]

[ "In", "addition", "to", "NB4", "cells", ",", "ATRA", "also", "activated", "IRF-1", "gene", "expression", "in", "HL-60", ",", "U937", ",", "and", "THP-1", "cells", ",", "which", "all", "respond", "to", "ATRA", "by", "growth", "inhibition", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 5, 0, 5, 0, 0, 5, 6, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Similar", "to", "the", "E2", "response", ",", "the", "slope", "factors", "for", "alpha-zearalenol", ",", "zearalenone", ",", "and", "genistein", "were", "close", "to", "3.0", ",", "suggesting", "positive", "cooperativity", "in", "the", "estrogenic", "response", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "On", "the", "contrary", ",", "other", "steroid", "hormones", "such", "as", "Tx", ",", "progesterone", ",", "and", "testosterone", "had", "no", "effect", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "This", "rhythmic", "differentiation", "disappeared", "after", "the", "patients", "had", "been", "given", "the", "antiandrogen", "drug", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "We", "propose", "from", "these", "results", "that", "the", "source", "of", "the", "fused", "fragment", "encompassing", "both", "ends", "of", "EBV", "DNA", "is", "a", "concatenated", "linear", "EBV", "DNA", "molecule", ",", "and", "that", "such", "a", "concatenated", "molecule", "most", "likely", "represents", "a", "replicative", "form", "of", "EBV", "DNA", "in", "productively", "infected", "cells", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 1, 2, 2, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0 ]

[ "Using", "these", "T", "cells", "as", "a", "model", "of", "IL-12", "signal", "transduction", ",", "we", "confirmed", "that", "these", "events", "involve", "members", "of", "the", "Janus", "kinase", "family", "of", "nonreceptor", "tyrosine", "kinases", "JAK2", ",", "TYK2", ",", "and", "signal", "transducer", "and", "activator", "of", "transcription", "4", "." ]

[ 0, 0, 7, 8, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 9, 10, 10, 9, 0, 9, 0, 0, 9, 10, 10, 10, 10, 10, 10, 0 ]

[ "IL-8", "secretion", "was", "accompanied", "by", "accumulation", "of", "IL-8", "mRNA", "in", "the", "cytosol", "and", "by", "nuclear", "expression", "of", "a", "kappaB", "DNA", "binding", "activity", "within", "30", "minutes", "." ]

[ 9, 0, 0, 0, 0, 0, 0, 3, 4, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0 ]

[ "These", "results", "provide", "evidence", "for", "differential", "regulation", "of", "the", "promoter", "function", "of", "CPO", "gene", "between", "erythroid", "and", "nonerythroid", "cells", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 7, 8, 8, 8, 0 ]

[ "These", "results", "demonstrated", "that", "LPS-mediated", "SAA", "gene", "induction", "in", "monocyte/macrophage", "cells", "is", "primarily", "due", "to", "the", "induction", "of", "SAF", "activity", "." ]

[ 0, 0, 0, 0, 0, 9, 0, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0 ]

[ "Consistent", "with", "a", "role", "for", "bcl-xL", "in", "mediating", "GATA-1", "-induced", "erythroid", "cell", "survival", ",", "in", "vitro-differentiated", "bcl-xL-/-", "embryonic", "stem", "cells", "fail", "to", "generate", "viable", "mature", "definitive", "erythroid", "cells", ",", "a", "phenotype", "resembling", "that", "of", "GATA-1", "gene", "disruption", "." ]

[ 0, 0, 0, 0, 0, 9, 0, 0, 9, 0, 0, 0, 0, 0, 0, 5, 6, 6, 6, 6, 0, 0, 0, 0, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0 ]

[ "Administration", "of", "dexamethasone", "to", "temporal", "artery-SCID", "chimeras", "for", "1", "wk", "induced", "a", "partial", "suppression", "of", "T", "cell", "and", "macrophage", "function", "as", "indicated", "by", "the", "reduced", "tissue", "concentrations", "of", "IL-2", ",", "IL-1beta", ",", "and", "IL-6", "mRNA", ",", "and", "by", "the", "diminished", "expression", "of", "inducible", "NO", "synthase", "." ]

[ 0, 0, 0, 0, 5, 6, 6, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 4, 4, 4, 4, 4, 4, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0 ]

[ "In", "this", "report", ",", "we", "show", "that", "Mycoplasma", "fermentans", "lipid-associated", "membrane", "proteins", "(", "LAMPf", ")", "induce", "the", "production", "of", "high", "levels", "of", "IL-8", "by", "THP-1", "(", "human", "monocyte", ")", "cells", "and", "PMN", "at", "the", "same", "extent", "as", "LPS", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 10, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 5, 6, 6, 6, 6, 6, 0, 7, 0, 0, 0, 0, 0, 0, 0 ]

[ "These", "data", "suggest", "that", "EA-D", "(", "BMRF1", ")", "promoter", "regulation", "by", "Z", "and", "R", "is", "cell", "type", "specific", "and", "appears", "to", "involve", "different", "mechanisms", "in", "each", "cell", "type", "." ]

[ 0, 0, 0, 0, 1, 2, 2, 2, 2, 0, 0, 9, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "GDSP", "significantly", "inhibited", "edema", "formation", ",", "neutrophil", "infiltration", ",", "acinar", "cell", "damage", ",", "and", "plasma", "lipase", "and", "amylase", "increases", "caused", "by", "cerulein", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 9, 0, 0, 0, 0, 0 ]

[ "Intracellular", "ILs", "were", "analyzed", "by", "flow", "cytometry", "." ]

[ 0, 9, 0, 0, 0, 0, 0, 0 ]

[ "However", ",", "only", "that", "located", "at", "the", "3", "'", "end", "appeared", "to", "be", "utilized", "in", "the", "2.3-kb", "cDNA", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0 ]

[ "These", "binding", "activities", "are", "expressed", "only", "in", "activated", "T", "cells", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 7, 8, 8, 0 ]

[ "The", "binding", "of", "E2F", "at", "this", "region", "was", "detected", "by", "a", "gel-retardation", "assay", "and", "DNaseI", "footprinting", "in", "phytohemagglutinin-stimulated", "T-lymphocytes", ",", "which", "was", "coincident", "with", "the", "expression", "of", "cdc2", "mRNA", "." ]

[ 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 5, 6, 0, 0, 0, 0, 0, 0, 0, 0, 3, 4, 0 ]

[ "The", "repetitive", "activation", "of", "T", "cells", "(", "priming", ")", "enhances", "the", "expression", "of", "many", "cytokines", ",", "such", "as", "IL-4", ",", "but", "not", "others", ",", "such", "as", "IL-2", "." ]

[ 0, 0, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0 ]

[ "NLS", "peptide-mediated", "disruption", "of", "the", "nuclear", "import", "of", "these", "transcription", "factors", "results", "in", "inhibition", "of", "I", "kappa", "B", "alpha", "and", "IL-2", "gene", "expression", ",", "processes", "dependent", "on", "NF-kappa", "B", "or", "the", "combination", "of", "NF-kappa", "B", ",", "AP-1", ",", "and", "NFAT", "." ]

[ 9, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 9, 10, 0, 9, 0, 0, 9, 0 ]

[ "Patients", "with", "AD", "(", "n", "=", "15", ")", "exhibited", "significantly", "more", "glucocorticoid", "receptors", "(", "GR", ")", "per", "cell", "than", "the", "control", "group", "(", "n", "=", "22", ")", ",", "while", "the", "GR", "affinity", "did", "not", "differ", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0 ]

[ "PU.1", "is", "completely", "absent", "from", "peripheral", "T", "cells", "and", "most", "T", "cell", "lines", "based", "on", "sensitive", "RT-PCR", "assays", "." ]

[ 9, 0, 0, 0, 0, 7, 8, 8, 0, 0, 5, 6, 6, 0, 0, 0, 0, 0, 0 ]

[ "PKC-epsilon", ",", "but", "not", "PKC-alpha", "nor", "activated", "p21ras", ",", "was", "able", "to", "induce", "NF-KB", "activity", "." ]

[ 9, 0, 0, 0, 9, 0, 0, 9, 0, 0, 0, 0, 0, 9, 0, 0 ]

[ "The", "importance", "of", "the", "central", "nervous", "system-enriched", "kappa", "B", "transcription", "factor", "in", "the", "regulation", "of", "HIV-1", "expression", "is", "discussed", "." ]

[ 0, 0, 0, 0, 9, 10, 10, 10, 10, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "To", "investigate", "the", "presence", "of", "various", "isoforms", "of", "the", "estrogen", "receptor", "(", "ER", ")", "in", "SLE", "we", "isolated", "RNA", "from", "mononuclear", "cells", "of", "lupus", "patients", "and", "normal", "controls", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 9, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0 ]

[ "In", "both", "T", "cells", "and", "HeLa", "cells", "HIV-1", "Tat", "suppressed", "the", "expression", "of", "Mn-dependent", "superoxide", "dismutase", "(", "Mn-SOD", ")", ",", "a", "mitochondrial", "enzyme", "that", "is", "part", "of", "the", "cellular", "defense", "system", "against", "oxidative", "stress", "." ]

[ 0, 0, 7, 8, 0, 5, 6, 9, 10, 0, 0, 0, 0, 9, 10, 10, 0, 9, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "In", "both", "transformed", "and", "normal", "lymphocytes", ",", "OKA", "stimulation", "induced", "intense", "phosphorylation", "of", "the", "constitutively", "expressed", "Sp1", "protein", "in", "the", "nucleus", ",", "a", "property", "of", "OKA", "not", "shared", "by", "TNF", ",", "phorbol", "ester", ",", "or", "PHA", "and", "interleukin", "2", "." ]

[ 0, 0, 7, 8, 8, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 9, 0, 9, 10, 0 ]

[ "We", "show", "that", "inhibition", "is", "not", "due", "to", "a", "direct", "modification", "of", "the", "active", "NF-kappaB", "heterodimer", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0 ]

[ "A", "sucrose", "gradient", "analysis", "indicated", "the", "simultaneous", "presence", "of", "two", "kinds", "of", "receptor", "complexes", ":", "the", "steroid-MR", "complex", "and", "the", "antibody-MR", "complex", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 9, 10, 0 ]

[ "These", "findings", "establish", "a", "spectrum", "of", "binding", "site-specific", "transcriptional", "properties", "for", "E2A-HLF", "which", "may", "preferentially", "activate", "expression", "of", "select", "subordinate", "genes", "as", "a", "homodimer", "and", "potentially", "antagonize", "expression", "of", "others", "through", "heteromeric", "interactions", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Northern", "(", "RNA", ")", "blots", "and", "binding", "assays", "showed", "that", "NF-IL6", "is", "the", "only", "known", "C/EBP", "family", "member", "which", "is", "increased", "when", "U937", "cells", "are", "activated", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 9, 10, 10, 0, 0, 0, 0, 5, 6, 0, 0, 0 ]

[ "We", "have", "investigated", "the", "role", "that", "C/EBP", "proteins", "play", "in", "induction", "and", "replication", "of", "HIV-1", "." ]

[ 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "The", "aim", "of", "this", "study", "was", "to", "investigate", "whether", "mutations", "in", "the", "glucocorticoid", "receptor", "could", "account", "for", "the", "increasing", "unresponsiveness", "of", "patients", "with", "chronic", "lymphatic", "leukemia", "(", "CLL", ")", "to", "combination", "chemotherapy", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Composite", "elements", "are", "regulatory", "modules", "of", "promoters", "or", "enhancers", "that", "consist", "of", "binding", "sites", "of", "two", "different", "but", "synergizing", "transcription", "factors", "." ]

[ 1, 2, 0, 1, 2, 0, 1, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0 ]

[ "Truncation", "of", "TR", "alpha", "1", "at", "amino", "acid", "210", "prevented", "additional", "complex", "formation", "in", "the", "presence", "of", "NE", "without", "affecting", "DNA", "binding", ",", "suggesting", "that", "the", "carboxyl-terminus", "of", "the", "TRs", "is", "essential", "for", "interaction", "with", "nuclear", "proteins", "." ]

[ 0, 0, 9, 10, 10, 0, 9, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 9, 0, 0, 0, 0, 0, 9, 10, 0 ]

[ "Furthermore", ",", "these", "oxidative", "stresses", "inhibited", "activity", "of", "calcineurin", ",", "a", "serine/", "threonine", "phosphatase", "that", "regulates", "NFAT", "activation", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 9, 0, 0 ]

[ "Recent", "studies", "have", "suggested", "that", "the", "diversity", "of", "TCR", "repertoire", "after", "primary", "immunization", "is", "conserved", "in", "memory", "T", "cells", "and", "that", "a", "progressive", "narrowing", "of", "this", "repertoire", "may", "take", "place", "during", "recall", "infections", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 7, 8, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "In", "addition", "to", "these", "novel", "E2F", "complexes", ",", "three", "distinct", "forms", "of", "unbound", "(", "free", ")", "E2F", "were", "resolved", "in", "gel", "shift", "experiments", "." ]

[ 0, 0, 0, 0, 9, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0 ]

[ "We", "demonstrate", "in", "this", "report", "that", "the", "5", "'", "flanking", "DNA", "of", "the", "15-lox", "gene", "contains", "sequences", "which", "down-regulate", "its", "activity", "in", "a", "variety", "of", "non-erythroid", "cell", "lines", "but", "not", "in", "two", "erythroid", "cell", "lines", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 2, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 6, 6, 0, 0, 0, 0, 5, 6, 6, 0 ]

[ "Sucrose", "gradient", "assays", "performed", "with", "[", "3H", "]", "aldosterone-MBP-HBD", "revealed", "complex", "sedimenting", "at", "8.3S", "and", "4.9S", "with", "[", "3H", "]", "progesterone-MBP-HBD", "." ]

[ 0, 0, 0, 0, 0, 9, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 0 ]

[ "Conversely", ",", "several", "cytokines", "modulate", "the", "levels", "of", "HIV", "expression", "in", "infected", "cells", "of", "both", "T", "lymphocytic", "and", "mononuclear", "phagocytic", "lineage", "." ]

[ 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 8, 8, 8, 8, 0 ]

[ "Cytokine", "and", "growth", "factor", "receptor", "engagement", "leads", "to", "the", "rapid", "phosphorylation", "and", "activation", "of", "latent", ",", "cytosolic", "signal", "transducers", "and", "activators", "of", "transcription", "(", "STAT", ")", "proteins", ",", "which", "then", "translocate", "to", "the", "nucleus", "where", "they", "regulate", "transcriptional", "events", "from", "specific", "promoter", "sequences", "." ]

[ 9, 0, 9, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 0 ]

[ "In", "contrast", ",", "Spi-B", "is", "expressed", "exclusively", "in", "lymphoid", "cells", "and", "can", "be", "detected", "in", "early", "fetal", "thymus", "and", "spleen", "." ]

[ 0, 0, 0, 9, 0, 0, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "In", "contrast", ",", "synthesis", "of", "IFN-gamma", "mRNA", "was", "only", "slightly", "decreased", ",", "and", "expression", "of", "TGF-beta1", "was", "unaffected", "." ]

[ 0, 0, 0, 0, 0, 3, 4, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0 ]

[ "By", "paired", "t-test", ",", "Bmax", "decreased", "significantly", "in", "the", "control", "group", "but", "not", "in", "the", "depressed", "group", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Lineage-specific", "expression", "is", "controlled", "at", "the", "level", "of", "mRNA", "transcription", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Additional", "mapping", "studies", "indicated", "that", "defined", "deletions", "of", "C-terminal", "70Z/3", "sequences", "affected", "to", "a", "variable", "degree", "its", "ability", "to", "stimulate", "NFAT", "activity", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0 ]

[ "Interestingly", ",", "evidence", "for", "the", "presence", "of", "B", "cells", "that", "have", "already", "switched", "to", "IgE", "was", "seen", "in", "PBMCs", "of", "several", "patients", "with", "asthma", "or", "HIE", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 7, 8, 0, 0, 0, 0, 0, 9, 0, 0, 0, 7, 0, 0, 0, 0, 0, 0, 0, 0 ]