Datasets:

---

siddharthtumre

/

jnlpba-split

like 0

[ "Aims", "of", "the", "study", "were", "to", "(", "1", ")", "assess", "the", "potential", "role", "of", "the", "expression", "of", "these", "genes", "in", "the", "maintenance", "and", "expansion", "of", "the", "neoplastic", "clones", "and", "(", "2", ")", "search", "for", "constitutional", "losses", "or", "rearrangements", "of", "one", "allele", "followed", "by", "a", "deletion", "of", "the", "second", "allele", "of", "the", "same", "genes", "in", "the", "leukemic", "cells", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 6, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 7, 8, 0 ]

[ "We", "have", "developed", "a", "three-layer", "Percoll", "density", "gradient", "that", "allows", "separation", "of", "the", "different", "granules", "and", "vesicles", "from", "human", "neutrophils", ";", "in", "particular", ",", "it", "allows", "separation", "of", "specific", "and", "gelatinase", "granules", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Moreover", ",", "the", "effect", "of", "cell", "adhesion", "to", "fibronectin", "or", "laminin", "was", "studied", "to", "investigate", "mechanisms", "involved", "in", "STAT1", "activation", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0 ]

[ "Since", "the", "human", "GM-CSF", "promoter", "has", "a", "base", "difference", "within", "the", "GC-box", ",", "we", "speculate", "that", "this", "may", "explain", "why", "the", "human", "promoter", "is", "weak", "and", "that", "an", "upstream", "enhancer", "is", "required", "for", "the", "induction", "of", "the", "human", "GM-CSF", "gene", "." ]

[ 0, 0, 1, 2, 2, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 0 ]

[ "However", ",", "cotransfection", "studies", "with", "an", "NF-AT", "expression", "vector", "showed", "that", "NF-AT", "may", "confer", "a", "strong", "inducible", "activity", "to", "the", "CD95L", "promoter", "at", "this", "regulatory", "region", "." ]

[ 0, 0, 0, 0, 0, 0, 1, 2, 2, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 1, 2, 0 ]

[ "IFN", "alpha", "levels", "were", "increased", "in", "the", "AIDS-GR", "group", "(", "17", "+/-", "6", "vs", "." ]

[ 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "In", "chickens", ",", "estrogens", "stimulate", "outgrowth", "of", "bone", "marrow-derived", "erythroid", "progenitor", "cells", "and", "delay", "their", "maturation", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 7, 8, 8, 8, 8, 0, 0, 0, 0, 0 ]

[ "Resistance", "to", "glucocorticoid", "therapy", "has", "been", "observed", "in", "patients", "with", "autoimmune/inflammatory", "diseases", "and", "may", "be", "related", "to", "the", "inflammatory", "process", "itself", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "HL-60", "cells", "constitutively", "expressing", "an", "Egr-1", "transgene", "(", "HL-60Egr-1", ")", "could", "be", "induced", "for", "macrophage", ",", "but", "not", "granulocyte", ",", "differentiation", "." ]

[ 5, 6, 0, 0, 0, 1, 2, 0, 1, 0, 0, 0, 0, 0, 7, 0, 0, 0, 7, 0, 0, 0 ]

[ "Pretreatment", "with", "dexamethasone", "tapered", "NFkappaB", "translocation", "into", "the", "nucleus", "." ]

[ 0, 0, 0, 0, 9, 0, 0, 0, 0, 0 ]

[ "Glucocorticoid", "receptors", "in", "human", "peripheral", "blood", "mononuclear", "cells", "in", "relation", "to", "age", "and", "to", "sport", "activity", "." ]

[ 9, 10, 0, 7, 8, 8, 8, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "This", "analysis", "identified", "one", "such", "element", "repeated", "four", "times", "within", "the", "CD11b", "promoter", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0 ]

[ "Since", "the", "DSE", "and", "TRE", "sites", "can", "not", "bind", "CREB/ATF", "homodimers", ",", "we", "propose", "a", "mechanism", "in", "which", "the", "HIV-1", "DSE", "bind", "heterodimers", "composed", "of", "both", "AP-1", "and", "CREB/ATF", "proteins", "." ]

[ 0, 0, 1, 0, 1, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 9, 0, 0, 0, 9, 10, 10, 10, 0 ]

[ "The", "data", "obtained", "demonstrate", "that", "phorbol", "dibutyrate/calcium", "ionophore", "A23187", "(", "PDBu/iono", ")", "combination", "induced", "a", "clearly", "higher", "nuclear", "translocation", "of", "NF-kappa", "B", "in", "neonatal", "than", "adult", "T", "cells", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 7, 8, 8, 8, 8, 0 ]

[ "This", "effect", "is", "independent", "of", "differentiation", "and", "is", "mediated", "by", "RAR", "alpha", "in", "HL-60", "cells", ",", "suggesting", "a", "similar", "role", "for", "RAR", "alpha", "in", "CD38", "expression", "in", "other", "hematopoietic", "cells", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 7, 8, 0, 0, 0, 0, 0, 0, 9, 10, 0, 9, 0, 0, 0, 7, 8, 0 ]

[ "Western", "blot", "with", "an", "N-terminal", "antibody", "showed", "normal", "levels", "of", "immunoreactive", "GR", ",", "but", "quantitative", "analysis", "with", "isoform-specific", "C-terminal", "antibodies", "revealed", "a", "markedly", "reduced", "GRalpha", "expression", ",", "and", "high", "GRbeta", "expression", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 9, 0, 0, 0, 0, 9, 0, 0 ]

[ "As", "a", "consequence", "of", "its", "effect", "on", "junB", "mRNA", ",", "IL-6", "stimulated", ",", "in", "a", "biphasic", "fashion", ",", "the", "nuclear", "accumulation", "of", "the", "JunB", "protein", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 3, 4, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0 ]

[ "Briefly", ",", "we", "found", "that", "1", ")", "rheumatoid", "synovial", "cells", "highly", "expressed", "CD44", ";", "2", ")", "cross-linking", "of", "CD44", "markedly", "but", "transiently", "augmented", "VCAM-1", "expression", "and", "its", "mRNA", "transcription", "much", "more", "than", "did", "IL-1beta", "and", "TNF-alpha", ";", "3", ")", "hyaluronan", ",", "especially", "when", "fragmented", ",", "also", "up-regulated", "VCAM-1", ";", "4", ")", "CD44", "activated", "the", "transcription", "factor", "AP-1", ";", "and", "5", ")", "the", "integrin", "-dependent", "adhesive", "function", "of", "RA", "synovial", "cells", "to", "T", "cells", "was", "also", "amplified", "by", "CD44", "cross-linking", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 7, 8, 8, 0, 0, 9, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 7, 8, 8, 0, 7, 8, 0, 0, 0, 0, 9, 0, 0 ]

[ "In", "this", "report", ",", "we", "demonstrate", "that", "the", "supernatant", "from", "activated", "T-lymphocytes", "is", "able", "to", "induce", "the", "transcription", "of", "a", "potent", "cytokine", ",", "TGF-beta", "2", "in", "glial", "cells", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 9, 10, 0, 7, 8, 0 ]

[ "We", "developed", "eukaryotic", "vectors", "suitable", "to", "imitate", "the", "processes", "involved", "in", "lytic", "transition", "in", "cell", "culture", "systems", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "These", "data", "suggest", "that", "Tax", "stimulates", "RNA", "polymerase", "III-dependent", "gene", "expression", "by", "accelerating", "the", "rate", "and/or", "extent", "of", "transcription", "initiation", "complex", "assembly", "." ]

[ 0, 0, 0, 0, 9, 0, 1, 2, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 0 ]

[ "Analogs", "of", "1", "alpha", ",", "25-dihydroxyvitamin", "D3", "(", "1", "alpha", ",", "25-", "(", "OH", ")", "2D3", ")", "with", "substitutions", "on", "C-11", "were", "synthesized", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "CONCLUSION", "." ]

[ 0, 0 ]

[ "The", "expression", "of", "many", "genes", "for", "which", "products", "are", "involved", "in", "inflammation", "is", "controlled", "by", "the", "transcriptional", "regulator", "nuclear", "factor", "(", "NF", ")", "-kappa", "B", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 10, 10, 10, 10, 10, 0 ]

[ "Moreover", ",", "replacement", "of", "the", "DQB", "X2-box", "with", "the", "DRA", "X2-box", "markedly", "diminished", "the", "activity", "of", "the", "DQB", "promoter", "in", "the", "mutant", "cell", "." ]

[ 0, 0, 0, 0, 0, 1, 2, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 5, 6, 0 ]

[ "NF-kappa", "B", "is", "involved", "in", "the", "transcriptional", "control", "of", "various", "genes", "that", "act", "as", "extrinsic", "and", "intrinsic", "survival", "factors", "for", "T", "cells", "." ]

[ 9, 10, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0 ]

[ "One", "of", "the", "major", "objectives", "in", "the", "study", "of", "thrombogenesis", "is", "to", "determine", "the", "mechanisms", "by", "which", "a", "hematopoietic", "progenitor", "is", "activated", "and", "committed", "to", "the", "megakaryocytic", "lineage", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 7, 8, 0 ]

[ "It", "was", "evaluated", "whether", "any", "of", "the", "variables", "might", "be", "used", "as", "a", "biomarker", "of", "effects", "for", "this", "class", "of", "compounds", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "These", "in", "vivo", "anti-inflammatory", "effects", "of", "IL-11", "were", "associated", "with", "reduced", "NF-kappaB", "activation", "in", "lung", ",", "reduced", "levels", "of", "tumor", "necrosis", "factor", "alpha", "(", "TNF-alpha", ")", "in", "bronchoalveolar", "lavage", "(", "BAL", ")", "fluids", ",", "and", "diminished", "up-regulation", "of", "lung", "vascular", "ICAM-1", "." ]

[ 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0 ]

[ "The", "results", "from", "9", "healthy", "volunteers", "(", "average", "GR", "concentration", "7131", "+/-", "1256", "sites/cell", ")", "correlated", "excellently", "with", "those", "obtained", "by", "the", "Scatchard", "analysis", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "However", ",", "BRL49653", ",", "a", "PPARgamma", "ligand", ",", "failed", "to", "induce", "MCP-1", "secretion", "either", "alone", "or", "to", "modify", "the", "expression", "level", "induced", "by", "RA", "." ]

[ 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Although", "lymphokine", "genes", "are", "coordinately", "regulated", "upon", "antigen", "stimulation", ",", "they", "are", "regulated", "by", "the", "mechanisms", "common", "to", "all", "as", "well", "as", "those", "which", "are", "unique", "to", "each", "gene", "." ]

[ 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Closer", "examination", "using", "non-transformed", "murine", "Th1", "and", "Th2", "clones", "suggested", "that", "a", "balance", "between", "the", "activities", "of", "the", "two", "signaling", "pathways", "contributes", "to", "cytokine", "gene", "expression", "." ]

[ 0, 0, 0, 5, 6, 6, 6, 6, 6, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0 ]

[ "Notably", ",", "the", "lack", "of", "pRB", "in", "these", "U937-derived", "clones", "renders", "these", "p53-null", "cells", "highly", "resistant", "to", "apoptosis", "induced", "by", "serum", "withdrawal", ",", "calphostin", "C", ",", "and", "ceramide", "." ]

[ 0, 0, 0, 0, 0, 9, 0, 0, 5, 6, 0, 0, 5, 6, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "We", "report", "here", "that", "1", ",", "25", "(", "OH", ")", "2D3-mediated", "repression", "in", "Jurkat", "cells", "is", "cycloheximide", "resistant", ",", "suggesting", "that", "it", "is", "a", "direct", "transcriptional", "repressive", "effect", "on", "IL-2", "expression", "by", "the", "vitamin", "D3", "receptor", "(", "VDR", ")", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 6, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 9, 10, 10, 0, 9, 0, 0 ]

[ "Functional", "studies", "in", "extrarenal", ",", "non-epithelial", "cells", "such", "as", "smooth", "muscle", "cells", "and", "more", "recently", "circulating", "human", "lymphocytes", "have", "provided", "increasing", "evidence", "that", "aldosterone", "produces", "not", "only", "classical", "genomic", "effects", ",", "but", "also", "rapid", ",", "non-genomic", "effects", "on", "transmembrane", "electrolyte", "movements", "." ]

[ 0, 0, 0, 7, 8, 8, 8, 0, 0, 7, 8, 8, 0, 0, 0, 7, 8, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "The", "observed", "E1a", "reiterations", "provide", "a", "model", "to", "gain", "insight", "into", "understanding", "the", "evolutionary", "events", "of", "some", ",", "if", "not", "all", ",", "adenovirus", "types", "during", "many", "years", "of", "symbiotic", ",", "persistent", "relationship", "in", "human", "tonsils", "and", "adenoids", "and", "possibly", "other", "lymphoid", "organs", "." ]

[ 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Phosphorylation", "of", "the", "transcription", "factor", "NFATp", "inhibits", "its", "DNA", "binding", "activity", "in", "cyclosporin", "A-treated", "human", "B", "and", "T", "cells", "." ]

[ 0, 0, 0, 9, 10, 9, 0, 0, 0, 0, 0, 0, 5, 6, 6, 6, 0, 7, 8, 0 ]

[ "Among", "these", "subsets", ",", "Th1", "cells", "are", "known", "to", "activate", "cellular", "immunity", "resulting", "in", "inflammatory", "response", ",", "whereas", "Th2", "cells", "induce", "humoral", "and", "allergic", "responses", "and", "suppress", "inflammation", "." ]

[ 0, 0, 0, 0, 5, 6, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 6, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Electrophoretic", "mobility", "shift", "assay", "analysis", "showed", "that", "Tax", "increased", "the", "DNA", "binding", "activity", "of", "both", "Sp1", "and", "NGFI-A/Egr-1", "using", "a", "TRE1", "probe", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 9, 0, 9, 0, 0, 1, 2, 0 ]

[ "The", "enhancer", "activity", "of", "the", "PRE", "was", "completely", "suppressed", "when", "the", "NRE", "was", "present", "." ]

[ 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 1, 0, 0, 0 ]

[ "Activation", "of", "T", "cells", "results", "in", "the", "rapid", "calcineurin", "-dependent", "translocation", "of", "NFAT", "transcription", "factors", "from", "the", "cytoplasm", "to", "the", "nucleus", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 9, 9, 10, 0, 0, 0, 0, 0, 0, 0 ]

[ "In", "this", "study", "we", "identified", "a", "sequence", "element", "present", "in", "the", "most", "proximal", "region", "located", "between", "bases", "-214", "and", "-201", ",", "TTCTTCTAATTAA", ",", "which", "is", "important", "in", "the", "high", "constitutive", "expression", "of", "CD20", "in", "mature", "B", "cells", "and", "the", "induction", "of", "CD20", "in", "pre-B", "cells", "." ]

[ 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 7, 8, 0 ]

[ "Processing", "of", "the", "precursor", "of", "NF-kappa", "B", "by", "the", "HIV-1", "protease", "during", "acute", "infection", "." ]

[ 0, 0, 0, 0, 0, 9, 10, 0, 0, 9, 10, 0, 0, 0, 0 ]

[ "Tissue", "factor", "(", "TF", ")", "expression", "by", "peripheral", "blood", "monocytes", "during", "sepsis", "initiates", "intravascular", "thrombosis", "." ]

[ 9, 10, 0, 0, 0, 0, 0, 7, 8, 8, 0, 0, 0, 0, 0, 0 ]

[ "Recombinant", "MZF-1", "protein", "specifically", "binds", "to", "the", "consensus", "binding", "sites", "in", "the", "CD34", "promoter", "in", "mobility", "shift", "assays", "." ]

[ 9, 10, 10, 0, 0, 0, 0, 1, 2, 2, 0, 0, 1, 2, 0, 0, 0, 0, 0 ]

[ "Expression", "of", "the", "human", "immunodeficiency", "virus", "type", "1", "(", "HIV", ")", "protease", "in", "cultured", "cells", "leads", "to", "apoptosis", ",", "preceded", "by", "cleavage", "of", "bcl-2", ",", "a", "key", "negative", "regulator", "of", "cell", "death", "." ]

[ 0, 0, 0, 9, 10, 10, 10, 10, 10, 10, 10, 10, 0, 5, 6, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Gel", "mobility", "shift", "assays", "using", "a", "synthetic", "E6", "motif", "detected", "a", "B-cell-specific", "complex", "in", "addition", "to", "a", "ubiquitous", "band", "found", "also", "in", "T", "cells", "and", "HeLa", "cells", "." ]

[ 0, 0, 0, 0, 0, 0, 1, 2, 2, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0, 5, 6, 0 ]

[ "In", "a", "subject", "with", "primary", "cortisol", "resistance", "we", "have", "observed", "glucocorticoid", "receptors", "(", "hGR", ")", "with", "a", "decreased", "affinity", "for", "dexamethasone", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Furthermore", ",", "we", "propose", "that", "these", "putative", "CD", "peptides", "bind", "to", "oligosaccharide", "residues", "on", "HLA", "class", "II", "molecules", "distal", "to", "the", "peptide-binding", "groove", "invoking", "recognition", "and", "binding", "by", "specialized", "subsets", "of", "gamma", "delta", "T", "cell", "receptor-bearing", "lymphocytes", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 8, 8, 8, 8, 0 ]

[ "cDNA", "cloning", "of", "a", "NGFI-B/nur77-related", "transcription", "factor", "from", "an", "apoptotic", "human", "T", "cell", "line", "." ]

[ 1, 0, 0, 0, 9, 10, 10, 0, 0, 5, 6, 6, 6, 6, 0 ]

[ "Regulatory", "effects", "of", "interleukin-11", "during", "acute", "lung", "inflammatory", "injury", "." ]

[ 0, 0, 0, 9, 0, 0, 0, 0, 0, 0 ]

[ "Clusters", "of", "genes", "with", "coherent", "expression", "patterns", "in", "cultured", "cells", "and", "in", "the", "breast", "tumors", "samples", "could", "be", "related", "to", "specific", "features", "of", "biological", "variation", "among", "the", "samples", "." ]

[ 0, 0, 1, 0, 0, 0, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "These", "cellular", "responses", "require", "intracellular", "signalling", "pathways", ",", "such", "as", "the", "four", "MAP", "kinase", "(", "MAPK", ")", "pathways", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 9, 0, 0, 0 ]

[ "Activation", "of", "the", "human", "delta-globin", "gene", "promoter", "in", "primary", "adult", "erythroid", "cells", "." ]

[ 0, 0, 0, 1, 2, 2, 2, 0, 7, 8, 8, 8, 0 ]

[ "Therefore", "oxygen", "therapy", "is", "helpful", "in", "raising", "the", "activity", "of", "glucocorticoid", "receptors", "and", "controlling", "the", "development", "of", "the", "disease", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Cell-cycle", "analysis", "showed", "that", "the", "growth-inhibitory", "effect", "of", "DES", ",", "TAM", "or", "quercetin", "was", "due", "to", "a", "blocking", "effect", "in", "the", "G0-G1", "phases", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "The", "present", "study", "shows", "that", "BCL-6", "expression", "is", "regulated", "in", "lymphocytes", "during", "mitogenic", "stimulation", "." ]

[ 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 7, 0, 0, 0, 0 ]

[ "The", "control", "of", "lytic", "replication", "of", "Epstein-Barr", "virus", "in", "B", "lymphocytes", "(", "Review", ")", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0, 0, 0, 0 ]

[ "It", "encodes", "a", "protein", "predicted", "to", "contain", "688", "amino", "acid", "residues", ",", "including", "11", "zinc", "finger", "motifs", "of", "the", "C2H2", "type", "in", "the", "C-terminal", "region", ",", "that", "are", "Kruppel-like", "in", "the", "conservation", "of", "the", "H/C", "link", "sequence", "connecting", "them", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 0, 9, 10, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 0, 0 ]

[ "SLP-76", "(", "SH2", "domain", "leukocyte", "protein", "of", "76", "kDa", ")", "is", "a", "recently", "identified", "substrate", "of", "the", "TCR-stimulated", "protein", "tyrosine", "kinases", "that", "functions", "in", "the", "signal", "transduction", "cascade", "linking", "the", "TCR", "with", "IL-2", "gene", "expression", "." ]

[ 9, 0, 9, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 9, 0, 0, 0 ]

[ "In", "situ", "hybridization", "to", "viral", "DNA", "and", "immunocytochemistry", "for", "Ad5", "E1A", "protein", "localized", "the", "virus", "to", "airway", "and", "alveolar", "epithelial", "cells", "." ]

[ 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 7, 8, 8, 0 ]

[ "Under", "these", "conditions", ",", "etoposide", "produced", "a", "biphasic", "activation", "of", "protein", "kinase", "C", ",", "which", "consisted", "in", "an", "early", "transient", "activation", "(", "from", "hours", "1", "to", "6", ")", "of", "the", "membrane-bound", "enzyme", "followed", "by", "a", "later", "activation", "(", "hour", "48", ")", "of", "the", "total", ",", "membrane-bound", "and", "cytosolic", "enzyme", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 0 ]

[ "Upon", "activation", "by", "antigens", ",", "helper", "T", "cells", "differentiate", "into", "one", "of", "several", "subsets", ",", "characterized", "by", "their", "distinct", "cytokine", "-production", "patterns", "." ]

[ 0, 0, 0, 9, 0, 7, 8, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0 ]

[ "These", "latter", "effects", "were", "due", "to", "increases", "in", "the", "nuclear", "localization", "of", "GR", ",", "not", "to", "reduced", "amounts", "of", "the", "other", "transcription", "factors", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0 ]

[ "Although", "phenotypically", "normal", ",", "the", "proliferative", "response", "of", "the", "childrens", "'", "T", "cells", "was", "strongly", "reduced", "but", "could", "be", "improved", "by", "the", "addition", "of", "interleukin-2", "(", "IL-2", ")", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 9, 0, 0 ]

[ "Phorbol", "ester", "treatment", "of", "a", "pre-B", "cell", "line", "up-regulated", "CD19", "expression", ",", "induced", "Egr-1", ",", "and", "enhanced", "the", "footprint", "over", "the", "GC", "box", "." ]

[ 0, 0, 0, 0, 0, 5, 6, 6, 0, 9, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Transient", "expression", "of", "HIV-1", "Tat", "induced", "a", "five-", "to", "eightfold", "increase", "in", "IL-2", "promoter", "activity", "in", "Jurkat", "T", "cells", "stimulated", "with", "phytohemagglutinin", "and", "phorbol", "myristate", "acetate", "." ]

[ 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 5, 6, 6, 0, 0, 9, 0, 0, 0, 0, 0 ]

[ "Recently", ",", "fibromyalgia", "(", "FMS", ")", "was", "shown", "to", "be", "a", "disorder", "associated", "with", "an", "altered", "functioning", "of", "the", "stress", "response", "system", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Human", "T-cell", "leukemia", "virus", "type", "I", "Tax", "activation", "of", "NF-kappa", "B/Rel", "involves", "phosphorylation", "and", "degradation", "of", "I", "kappa", "B", "alpha", "and", "RelA", "(", "p65", ")", "-mediated", "induction", "of", "the", "c-rel", "gene", "." ]

[ 0, 0, 0, 0, 0, 0, 9, 0, 0, 9, 10, 0, 0, 0, 0, 0, 9, 10, 10, 10, 0, 9, 0, 9, 0, 0, 0, 0, 0, 1, 2, 0 ]

[ "These", "results", "demonstrate", "distinct", "patterns", "of", "intracellular", "signaling", "for", "two", "chemoattractants", "and", "suggest", "that", "selective", "activation", "of", "intracellular", "signaling", "cascades", "may", "underlie", "different", "patterns", "of", "functional", "responses", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "CONCLUSION", "." ]

[ 0, 0 ]

[ "To", "investigate", "the", "role", "of", "Stat6", "in", "regulating", "IL-4", "transcription", ",", "we", "used", "Stat6", "-deficient", "Jurkat", "T", "cells", "with", "different", "intact", "IL-4", "promoter", "constructs", "in", "cotransfection", "assays", "." ]

[ 0, 0, 0, 0, 0, 9, 0, 0, 9, 0, 0, 0, 0, 9, 0, 0, 7, 8, 0, 0, 0, 1, 2, 2, 0, 0, 0, 0 ]

[ "The", "role", "of", "PPARgamma", "in", "human", "atherosclerosis", "is", "unexplored", "." ]

[ 0, 0, 0, 9, 0, 0, 0, 0, 0, 0 ]

[ "To", "examine", "the", "hypothesis", "that", "interleukin-6", "(", "IL-6", ")", "contributes", "to", "PMN", "infiltration", "and", "lung", "damage", "in", "HS", ",", "we", "examined", "the", "lungs", "of", "rats", "subjected", "to", "unresuscitated", "and", "resuscitated", "HS", "for", "the", "production", "of", "IL-6", "and", "activation", "of", "Stat3", "." ]

[ 0, 0, 0, 0, 0, 9, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 9, 0 ]

[ "In", "contrast", "to", "the", "purely", "enhancer-dependent", "effect", "of", "cytokines", "such", "as", "TNF", "on", "the", "activity", "of", "the", "HIV", "regulatory", "region", "(", "LTR", ")", ",", "we", "observed", "that", "okadaic", "acid", "(", "OKA", ")", "activates", "HIV", "transcription", "through", "both", "the", "enhancer", ",", "responding", "to", "the", "factor", "NF-kappa", "B", ",", "and", "the", "promoter", "domain", "of", "the", "LTR", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 9, 0, 0, 0, 0, 0, 1, 2, 2, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 1, 2, 0, 0, 1, 0 ]

[ "In", "contrast", ",", "ligand", "activation", "of", "c-Kit", "was", "unable", "to", "induce", "any", "of", "these", "effects", "in", "the", "same", "cells", "." ]

[ 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "This", "study", "describes", "the", "characterization", "of", "two", "additional", "cis-acting", "elements", "that", "interact", "with", "members", "of", "the", "NF", "kappa", "B/rel", "transcription", "factor", "family", "in", "an", "IL-4", "-independent", "fashion", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 10, 10, 0, 0, 9, 0, 0, 0 ]

[ "Moreover", ",", "M-CSF", "-induced", "expression", "of", "the", "fos-related", "gene", ",", "fra-1", ",", "was", "delayed", "compared", "to", "that", "for", "both", "c-fos", "and", "fos-B", "." ]

[ 0, 0, 9, 0, 0, 0, 0, 1, 2, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 1, 0 ]

[ "These", "protoenhancers", "alone", "are", "weakly", "or", "not", "responsive", "to", "R", "." ]

[ 0, 1, 0, 0, 0, 0, 0, 0, 0, 9, 0 ]

[ "Taken", "together", ",", "these", "observations", "suggest", "that", "mitogenic", "activation", ",", "mediated", "primarily", "through", "the", "NF", "kappa", "B", "enhancer", ",", "is", "susceptible", "to", "CD8", "-mediated", "inhibition", ",", "however", ",", "inhibition", "of", "Tat", "-mediated", "activation", "may", "rely", "upon", "a", "different", "pathway", "that", "is", "NFAT-1", "dependent", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 2, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0 ]

[ "In", "addition", ",", "V3-BH10", "generated", "the", "arrest", "of", "Kit225", "cells", "and", "also", "purified", "CD8-positive", "lymphocytes", "in", "G1", "phase", "in", "the", "presence", "of", "IL-2", "." ]

[ 0, 0, 0, 9, 0, 0, 0, 0, 5, 6, 0, 0, 5, 6, 6, 0, 0, 0, 0, 0, 0, 0, 9, 0 ]

[ "Protein-DNA", "binding", "studies", "suggested", "that", "Sp1", "and", "two", "other", "CCGCCC", "binding", "proteins", "from", "erythroid", "and", "non-erythroid", "cells", "could", "bind", "to", "the", "Sp1", "binding", "motif", "." ]

[ 0, 0, 0, 0, 0, 9, 0, 0, 0, 9, 10, 10, 0, 7, 8, 8, 8, 0, 0, 0, 0, 1, 2, 2, 0 ]

[ "In", "vitro", "apoptosis", "induction", "in", "CLL", "cells", "was", "delayed", "in", "response", "to", "GCs", ",", "but", "not", "to", "other", "apoptosis", "inducers", "." ]

[ 0, 0, 0, 0, 0, 5, 6, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Increasing", "RA", "concentrations", "reduced", "the", "D3", "concentration", "required", "for", "monocyte", "differentiation", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "E-selectin", "is", "induced", "within", "1-2", "h", ",", "peaks", "at", "4-6", "h", ",", "and", "gradually", "returns", "to", "basal", "level", "by", "24", "h", "." ]

[ 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Although", "many", "second", "messengers", "have", "been", "shown", "to", "be", "necessary", "and", "sufficient", "for", "T", "cell", "activation", "in", "a", "number", "of", "model", "systems", ",", "the", "rate-limiting", "step", "in", "peripheral", "T", "cells", "has", "not", "been", "demonstrated", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 8, 0, 0, 0, 0, 0 ]

[ "METHODS", ":", "We", "compared", "hydrocortisone", ",", "beclomethasone", "dipropionate", ",", "triamcinolone", "acetonide", ",", "flunisolide", ",", "and", "budesonide", "with", "regard", "to", "their", "capacity", "to", "inhibit", "phytohemagglutinin", "-induced", "peripheral", "blood", "mononuclear", "cell", "proliferation", "from", "six", "patients", "with", "steroid-sensitive", "asthma", "and", "seven", "patients", "with", "steroid-resistant", "asthma", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 7, 8, 8, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "The", "mechanism", "by", "which", "progesterone", "causes", "localized", "suppression", "of", "the", "immune", "response", "during", "pregnancy", "has", "remained", "elusive", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Thus", ",", "the", "block", "of", "apoptosis", "imposed", "by", "E2A-HLF", "in", "pro-B", "lymphocytes", "depends", "critically", "on", "the", "transactivating", "regions", "of", "E2A", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 7, 8, 0, 0, 0, 0, 9, 10, 0, 9, 0 ]

[ "We", "have", "investigated", "the", "effects", "of", "acetylsalicylic", "acid", "and", "sodium", "salicylate", "on", "the", "LPS-induced", "synthesis", "of", "the", "pro-coagulant", "protein", "tissue", "factor", "(", "TF", ")", "and", "the", "pro-inflammatory", "protein", "tumor", "necrosis", "factor-alpha", "(", "TNF-alpha", ")", ",", "as", "well", "as", "the", "prostaglandin", "PGE2", "in", "human", "monocytes", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 9, 10, 0, 7, 8, 0 ]

[ "We", "measured", "the", "number", "of", "glucocorticoid", "receptors", "(", "GR", ")", "in", "cord", "blood", "lymphocytes", "and", "the", "binding", "affinity", "(", "Kd", ")", "in", "15", "term", "and", "in", "20", "preterm", "babies", "." ]

[ 0, 0, 0, 0, 0, 9, 10, 0, 9, 0, 0, 7, 8, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "The", "independence", "of", "intracellular", "electrolytes", "from", "aldosterone", "despite", "a", "normal", "number", "of", "mineralocorticoid", "receptors", "may", "reflect", "an", "impairment", "of", "the", "mineralocorticoid", "effector", "mechanism", "in", "the", "HML", "of", "patients", "with", "essential", "hypertension", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 0, 0, 0, 0, 0, 0 ]

[ "The", "data", "obtained", "show", "that", "the", "three", "GCH", "molecules", "exert", "an", "immunosuppression", "on", "cytokine", "production", "by", "T", "lymphocytes", "and", "a", "strong", "decrease", "in", "the", "nuclear", "translocation", "of", "NF-kB", "in", "Jurkat", "cells", ";", "moreover", ",", "(", "a", ")", "not", "all", "the", "cytokines", "investigated", "were", "affected", ",", "and", "not", "with", "the", "same", "intensity", ",", "by", "the", "three", "GCH", "and", "(", "b", ")", "DXM", "inhibited", "the", "binding", "activity", "of", "NF-kB", "less", "than", "that", "of", "DFC", "and", "PDN", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 5, 6, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "The", "unique", "characteristics", "of", "this", "new", "pathway", "for", "steroid", "action", "include", "its", "rapid", "time", "course", ",", "10", ",", "000-fold", "selectivity", "for", "aldosterone", "over", "cortisol", "and", "the", "ineffectiveness", "of", "spironolactones", ",", "classical", "mineralocorticoid", "antagonists", ",", "as", "antagonists", "of", "the", "response", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "The", "adoptive", "transfer", "of", "tumor-draining", "lymph", "node", "(", "LN", ")", "T", "cells", "activated", "ex", "vivo", "with", "anti-CD3", "and", "interleukin", "2", "(", "IL-2", ")", "mediates", "the", "regression", "of", "the", "poorly", "immunogenic", "murine", "melanoma", "D5", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0, 0, 0, 0, 9, 0, 9, 10, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Transgenic", "expression", "of", "PML/RARalpha", "impairs", "myelopoiesis", "." ]

[ 0, 0, 0, 9, 0, 0, 0 ]

[ "Cross-linking", "of", "FcR", ",", "on", "the", "THP-1", "monocytic", "cell", "line", ",", "by", "immune", "complexes", "resulted", "in", "both", "activation", "of", "the", "transcription", "factor", "NF-kappaB", "and", "interleukin", "1", "production", "." ]

[ 0, 0, 9, 0, 0, 0, 5, 6, 6, 6, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 9, 10, 9, 0, 9, 10, 0, 0 ]

[ "Detection", "of", "oestrogen", "receptor", "variants", "in", "endometrium", ",", "myometrium", ",", "leiomyoma", "and", "peripheral", "blood", "mononuclear", "cells", ":", "comparison", "to", "variants", "present", "in", "breast", "cancer", "." ]

[ 0, 0, 9, 10, 10, 0, 0, 0, 0, 0, 0, 0, 7, 8, 8, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Constitutive", "binding", "of", "further", "factor", "proteins", "to", "DNA", ",", "such", "as", "JunD", ",", "c-Fos", "and", "FosB", ",", "was", "detected", "in", "several", "patients", "whereas", "the", "localisation", "and", "DNA", "binding", "of", "other", "factors", "such", "as", "c-Jun", ",", "RelA/p65", "and", "c-Rel", "was", "unaltered", "." ]

[ 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 9, 0, 9, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 9, 0, 9, 0, 0, 0 ]