id
stringlengths 1
5
| tokens
sequence | ner_tags
sequence |
---|---|---|
7712 | [
"Finally",
",",
"we",
"demonstrate",
"that",
"a",
"failure",
"to",
"degrade",
"IkappaB-alpha",
"in",
"cytosols",
"of",
"TNF-treated",
"T",
"cells",
"pretreated",
"with",
"PAO",
"is",
"due",
"to",
"its",
"interference",
"with",
"the",
"phosphorylation",
"of",
"IkappaB-alpha",
"and",
"not",
"due",
"to",
"its",
"inhibitory",
"effect",
"on",
"proteasomal",
"degradation",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
0,
0,
7,
8,
8,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
4827 | [
"Regulation",
"of",
"the",
"transcription",
"factor",
"NF-kappaB",
"involves",
"proteasome-mediated",
"processing",
"of",
"the",
"NF-kappaB1",
"p105",
"precursor",
"protein",
",",
"which",
"generates",
"the",
"p50",
"subunit",
"of",
"NF-kappaB",
"."
] | [
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
9,
10,
10,
10,
0,
0,
0,
0,
9,
10,
0,
9,
0
] |
9610 | [
"Other",
"variables",
",",
"including",
"plasma",
"hormone",
"and",
"electrolyte",
"values",
"and",
"binding",
"characteristics",
"for",
"dexamethasone",
",",
"were",
"not",
"different",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
16400 | [
"Formation",
"of",
"the",
"protein-DNA",
"complex",
"with",
"the",
"C26",
"subfragment",
"was",
"positively",
"affected",
"by",
"p40tax",
"."
] | [
0,
0,
0,
9,
10,
0,
0,
9,
10,
0,
0,
0,
0,
9,
0
] |
10799 | [
"A",
"large",
"amount",
"of",
"detailed",
"information",
"about",
"the",
"intracellular",
"proteins",
"regulating",
"NF-kappa",
"B",
"activation",
"and",
"the",
"cellular",
"response",
"to",
"NF-kappa",
"B",
"activation",
"has",
"emerged",
"recently",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
0,
9,
10,
0,
0,
0,
0,
0,
0,
9,
10,
0,
0,
0,
0,
0
] |
7089 | [
"Analogous",
"to",
"costimulation",
"via",
"CD28",
",",
"this",
"activity",
"is",
"mediated",
"through",
"activation",
"of",
"Rel/kappaB",
",",
"a",
"family",
"of",
"transcription",
"factors",
"known",
"to",
"regulate",
"IL-2",
"and",
"other",
"activation-inducible",
"proteins",
"."
] | [
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
9,
10,
0,
0,
0,
9,
0,
0,
9,
10,
0
] |
15973 | [
"HIV",
"enhancer",
"activity",
"perpetuated",
"by",
"NF-kappa",
"B",
"induction",
"on",
"infection",
"of",
"monocytes",
"[",
"see",
"comments",
"]"
] | [
1,
2,
0,
0,
0,
9,
10,
0,
0,
0,
0,
7,
0,
0,
0,
0
] |
11363 | [
"Jak3",
"is",
"constitutively",
"associated",
"with",
"CD40",
",",
"and",
"this",
"interaction",
"requires",
"a",
"proline-rich",
"sequence",
"in",
"the",
"membrane-proximal",
"region",
"of",
"CD40",
"."
] | [
9,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
9,
10,
0,
0,
9,
10,
0,
9,
0
] |
18122 | [
"Data",
"from",
"cell",
"culture",
"and",
"animal",
"studies",
"indicate",
"that",
"TR",
"expression",
"may",
"be",
"regulated",
"to",
"modulate",
"target",
"organ",
"responsiveness",
"to",
"thyroid",
"hormone",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
10426 | [
"Their",
"different",
"activities",
"on",
"the",
"RA",
"signalling",
"pathway",
"might",
"underlie",
"the",
"different",
"responses",
"of",
"PML-RAR",
"alpha",
"and",
"PLZF-RAR",
"alpha",
"APLs",
"to",
"RA",
"treatment",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
0,
9,
10,
0,
0,
0,
0,
0
] |
16360 | [
"Nucleotide",
"sequence",
"and",
"PCR",
"analyses",
"demonstrated",
"the",
"presence",
"of",
"novel",
"duplications",
"or",
"deletions",
"involving",
"the",
"NF-kappa",
"B",
"motif",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
2,
0
] |
11413 | [
"GATA-1",
"protein",
"and",
"mRNA",
"vary",
"in",
"a",
"similar",
"manner",
"through",
"the",
"cell",
"cycle",
",",
"suggesting",
"that",
"the",
"expression",
"of",
"the",
"gene",
"or",
"the",
"stability",
"of",
"its",
"message",
"is",
"regulated",
"."
] | [
9,
0,
0,
3,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
13127 | [
"It",
"was",
"concluded",
"that",
"even",
"when",
"LMP1",
"is",
"unable",
"to",
"activate",
"NF-kappaB",
",",
"it",
"is",
"still",
"capable",
"of",
"inducing",
"certain",
"characteristics",
"of",
"activated",
"B",
"cells",
",",
"strongly",
"suggesting",
"that",
"LMP1",
"can",
"also",
"activate",
"cells",
"independently",
"of",
"NF-kappaB",
"."
] | [
0,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
7,
8,
8,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
9,
0
] |
1643 | [
"Transcription",
"from",
"the",
"IL-2R",
"alpha",
"promoter",
"was",
"inhibited",
"when",
"either",
"the",
"Elf-1",
"or",
"the",
"HMG-I",
"(",
"Y",
")",
"binding",
"site",
"was",
"mutated",
"."
] | [
0,
0,
0,
1,
2,
2,
0,
0,
0,
0,
0,
1,
2,
2,
2,
2,
2,
2,
2,
2,
0,
0,
0
] |
3997 | [
"Receptors",
"were",
"measured",
"by",
"radioreceptor",
"assay",
"."
] | [
0,
0,
0,
0,
0,
0,
0
] |
709 | [
"Neutrophils",
"and",
"monocytes",
"express",
"high",
"levels",
"of",
"PU.1",
"(",
"Spi-1",
")",
"but",
"not",
"Spi-B",
"."
] | [
7,
0,
7,
0,
0,
0,
0,
9,
0,
9,
0,
0,
0,
9,
0
] |
8590 | [
"The",
"inhibition",
"of",
"IL-2",
"production",
"was",
"observed",
"in",
"the",
"CD3",
"(",
"+",
")",
"T-lymphocyte",
"cytoplasm",
"as",
"early",
"as",
"4",
"h",
"after",
"activation",
"by",
"PMA+ionomycin",
"."
] | [
0,
0,
0,
9,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
10512 | [
"TCP",
"succinate",
"(",
"20",
"microM",
",",
"72",
"h",
")",
",",
"but",
"not",
"TCP",
"(",
"200",
"microM",
",",
"72",
"h",
")",
",",
"reduced",
"U-937",
"cell",
"adhesion",
"to",
"TNF-alpha-stimulated",
"(",
"10",
"U/ml",
",",
"6",
"h",
")",
"HUVEC",
"by",
"30",
"%",
"(",
"P",
"<",
"0.025",
")",
"and",
"to",
"IL-1",
"beta-stimulated",
"HUVEC",
"by",
"56",
"%",
"(",
"P",
"<",
"0.010",
")",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
5,
6,
0,
0,
5,
6,
6,
6,
6,
6,
6,
6,
6,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
5,
6,
6,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
9181 | [
"Only",
"FMS",
"patients",
"displayed",
"lower",
"CBG",
"and",
"basal",
"serum",
"cortisol",
"concentrations",
"when",
"compared",
"to",
"controls",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
13620 | [
"Copyright",
"1998",
"by",
"The",
"American",
"Society",
"of",
"Hematology",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
2007 | [
"CD14",
",",
"a",
"monocyte/macrophage",
"receptor",
"for",
"the",
"complex",
"of",
"LPS",
"and",
"LPS",
"binding",
"protein",
",",
"is",
"a",
"differentiation",
"marker",
"for",
"the",
"monocyte/macrophage",
"lineage",
"."
] | [
9,
0,
0,
9,
10,
0,
0,
0,
0,
0,
0,
9,
10,
10,
0,
0,
0,
0,
0,
0,
0,
7,
8,
0
] |
16784 | [
"Furthermore",
",",
"we",
"found",
"that",
"cytoplasmic",
"acidification",
"facilitated",
"NF-kappa",
"B",
"activation",
"by",
"both",
"TNF",
"alpha",
"and",
"PKC",
",",
"by",
"a",
"mechanism",
"that",
"increases",
"NF-kappa",
"B",
"/I",
"kappa",
"B",
"dissociation",
"without",
"affecting",
"the",
"NF-kappa",
"B",
"translocation",
"step",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
0,
0,
0,
9,
10,
0,
9,
0,
0,
0,
0,
0,
0,
9,
10,
9,
10,
10,
0,
0,
0,
0,
9,
10,
0,
0,
0
] |
1273 | [
"This",
"function",
"was",
"a",
"result",
"of",
"the",
"interaction",
"of",
"EBV",
"with",
"its",
"receptor",
",",
"CD21",
",",
"but",
"was",
"caused",
"by",
"infection",
"rather",
"than",
"surface",
"signaling",
",",
"because",
"neither",
"specific",
"mAb",
"nor",
"the",
"P3HR-1",
"strain",
"of",
"virus",
"mimicked",
"the",
"effect",
"of",
"B95-8",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
13338 | [
"The",
"Fy",
"(",
"a-b-",
")",
"phenotype",
"has",
"been",
"associated",
"with",
"a",
"mutation",
"in",
"the",
"FY*B",
"promoter",
"at",
"the",
"GATA",
"box",
"that",
"abolishes",
"the",
"expression",
"of",
"erythrocyte",
"Duffy",
"protein",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
0,
0,
1,
2,
0,
0,
0,
0,
0,
9,
10,
10,
0
] |
7516 | [
"Acute",
"inflammatory",
"injury",
"in",
"rat",
"lung",
"induced",
"by",
"deposition",
"of",
"immunoglobulin",
"G",
"immune",
"complexes",
"requires",
"expression",
"of",
"cytokines",
"and",
"chemokines",
"as",
"well",
"as",
"activation",
"of",
"the",
"transcription",
"factor",
"nuclear",
"factor",
"(",
"NF",
")",
"-kappaB",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
10,
10,
0,
0,
0,
9,
0,
9,
0,
0,
0,
0,
0,
0,
9,
10,
9,
10,
10,
10,
10,
10,
0
] |
11037 | [
"The",
"SRG3",
"protein",
"is",
"expressed",
"about",
"three",
"times",
"higher",
"in",
"thymocytes",
"than",
"in",
"peripheral",
"lymphocytes",
"."
] | [
0,
9,
10,
0,
0,
0,
0,
0,
0,
0,
7,
0,
0,
7,
8,
0
] |
15338 | [
"Blockade",
"of",
"the",
"DNA-binding",
"complexes",
"with",
"an",
"anti-Fos",
"mAb",
"demonstrated",
"a",
"direct",
"participation",
"of",
"c-Fos",
"in",
"the",
"AP-1",
"complexes",
"induced",
"by",
"anti-AIM",
"mAb",
"."
] | [
0,
0,
0,
9,
10,
0,
0,
9,
10,
0,
0,
0,
0,
0,
9,
0,
0,
9,
10,
0,
0,
9,
10,
0
] |
16252 | [
"The",
"cloning",
"of",
"the",
"complementary",
"DNA",
"for",
"the",
"50K",
"subunit",
"helped",
"to",
"identify",
"an",
"exclusively",
"cytoplasmic",
"105K",
"precursor",
"(",
"p105",
")",
"(",
"V.B.",
",",
"P.K.",
"and",
"A.I.",
",",
"manuscript",
"submitted",
")",
"."
] | [
0,
0,
0,
0,
1,
2,
0,
0,
9,
10,
0,
0,
0,
0,
0,
9,
10,
10,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
17933 | [
"Functional",
"studies",
"with",
"IL-6",
"promoter",
"demonstrated",
"that",
"three",
"regions",
"are",
"the",
"targets",
"of",
"the",
"IFN-gamma",
"and/or",
"TNF-alpha",
"action",
",",
"whereas",
"only",
"one",
"of",
"these",
"regions",
"seemed",
"to",
"be",
"implicated",
"in",
"LPS",
"activation",
"."
] | [
0,
0,
0,
1,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
13193 | [
"Abnormal",
"NFkappaB",
"activation",
"after",
"stimulation",
"with",
"phorbol",
"myristate",
"acetate/ionomycin",
"and/or",
"anti-CD3",
"monoclonal",
"antibody",
"was",
"found",
"in",
"59",
"%",
"of",
"patients",
"(",
"17",
"of",
"28",
")",
"and",
"was",
"not",
"accounted",
"for",
"by",
"the",
"advanced",
"age",
"of",
"the",
"study",
"cohort",
"."
] | [
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
10,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
1045 | [
"Thus",
",",
"erythroid",
"development",
"of",
"M-TAT",
"cells",
"is",
"promoted",
"by",
"EPO",
"and",
"suppressed",
"by",
"GM-CSF",
"."
] | [
0,
0,
0,
0,
0,
5,
6,
0,
0,
0,
9,
0,
0,
0,
9,
0
] |
1712 | [
"Taken",
"together",
",",
"these",
"data",
"indicated",
"that",
"inhibiting",
"nuclear",
"translocation",
"of",
"c-Rel/p65",
"heterodimers",
"prevented",
"LPS",
"induction",
"of",
"TF",
"gene",
"transcription",
"in",
"monocytic",
"cells",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
0,
0,
0,
0,
9,
0,
0,
0,
7,
8,
0
] |
1989 | [
"Human",
"T-cell",
"clones",
"reactive",
"with",
"gC",
"and",
"VP16",
"are",
"reported",
"here",
"for",
"the",
"first",
"time",
"."
] | [
5,
6,
6,
0,
0,
9,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0
] |
14519 | [
"Transcriptional",
"activation",
"of",
"the",
"HIV",
"enhancer",
"was",
"also",
"subject",
"to",
"regulation",
"by",
"recently",
"cloned",
"I",
"kappa",
"B-alpha",
"(",
"MAD-3",
")",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
10,
0,
9,
0,
0
] |
16695 | [
"The",
"HB24",
"mRNA",
"was",
"absent",
"or",
"present",
"at",
"low",
"levels",
"in",
"normal",
"B",
"and",
"T",
"lymphocytes",
";",
"however",
",",
"with",
"the",
"appropriate",
"activation",
"signal",
"HB24",
"mRNA",
"was",
"induced",
"within",
"several",
"hours",
"even",
"in",
"the",
"presence",
"of",
"cycloheximide",
"."
] | [
0,
3,
4,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
7,
8,
0,
0,
0,
0,
0,
0,
0,
0,
3,
4,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
12082 | [
"Carboxylesterases",
"play",
"an",
"important",
"role",
"in",
"defense",
"and",
"clearance",
"mechanisms",
"of",
"the",
"monocyte/macrophage",
"system",
"."
] | [
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
3949 | [
"Functional",
"studies",
"demonstrated",
"that",
"transcriptional",
"activation",
"of",
"a",
"plasmid",
"containing",
"multimerized",
"kappaB",
"sites",
"by",
"p65",
"was",
"inhibited",
"by",
"agents",
"that",
"elevate",
"cAMP",
"and",
"by",
"overexpression",
"of",
"the",
"catalytic",
"subunit",
"of",
"PKA",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
1,
0,
1,
2,
2,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
0,
9,
0
] |
12207 | [
"The",
"upstream",
"regions",
"UAS3",
"(",
"-1168",
"to",
"-440",
")",
"and",
"UAS2",
"(",
"-352",
"to",
"-264",
")",
"both",
"functioned",
"in",
"a",
"cell",
"lineage-independent",
"manner",
"and",
"were",
"together",
"responsible",
"for",
"the",
"bulk",
"of",
"Wp",
"activity",
"in",
"non-B",
"cells",
";",
"mutational",
"analysis",
"indicated",
"the",
"importance",
"of",
"a",
"YY1",
"binding",
"site",
"in",
"UAS2",
"in",
"that",
"context",
"."
] | [
0,
0,
0,
1,
0,
1,
2,
2,
0,
0,
1,
0,
1,
2,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
7,
8,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
2,
0,
1,
0,
0,
0,
0
] |
8677 | [
"Human",
"T-cell",
"leukemia",
"virus",
"type",
"1",
"tax",
"protein",
"abrogates",
"interleukin-2",
"dependence",
"in",
"a",
"mouse",
"T-cell",
"line",
"."
] | [
9,
10,
10,
10,
10,
10,
10,
10,
0,
9,
0,
0,
0,
5,
6,
6,
0
] |
1370 | [
"Characterization",
"of",
"the",
"CD48",
"gene",
"demonstrates",
"a",
"positive",
"element",
"that",
"is",
"specific",
"to",
"Epstein-Barr",
"virus-immortalized",
"B-cell",
"lines",
"and",
"contains",
"an",
"essential",
"NF-kappa",
"B",
"site",
"."
] | [
0,
0,
0,
1,
2,
0,
0,
0,
0,
0,
0,
0,
0,
7,
8,
8,
8,
0,
0,
0,
0,
1,
2,
2,
0
] |
13796 | [
"To",
"investigate",
"the",
"function",
"of",
"the",
"activated",
"Stat-3",
",",
"Jurkat",
"T",
"cells",
"were",
"transiently",
"transfected",
"with",
"a",
"Stat-3",
"isoform",
"lacking",
"the",
"transactivating",
"domain",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
9,
0,
5,
6,
6,
0,
0,
0,
0,
0,
9,
10,
0,
0,
9,
10,
0
] |
28 | [
"Lack",
"of",
"full",
"activation",
"of",
"NF-AT",
"could",
"be",
"correlated",
"to",
"a",
"dramatically",
"reduced",
"capacity",
"to",
"induce",
"calcium",
"flux",
"and",
"could",
"be",
"complemented",
"with",
"a",
"calcium",
"ionophore",
"."
] | [
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
9913 | [
"Rather",
",",
"helenalin",
"modifies",
"the",
"NF-kappaB/IkappaB",
"complex",
",",
"preventing",
"the",
"release",
"of",
"IkappaB",
"."
] | [
0,
0,
0,
0,
0,
9,
10,
0,
0,
0,
0,
0,
9,
0
] |
18270 | [
"Recently",
"the",
"MHC",
"class",
"II",
"transactivator",
"(",
"CIITA",
")",
"has",
"been",
"reported",
"to",
"be",
"a",
"major",
"regulatory",
"factor",
"for",
"both",
"the",
"constitutive",
"and",
"IFN",
"inducible",
"expression",
"of",
"MHC",
"class",
"II",
"genes",
"."
] | [
0,
0,
9,
10,
10,
10,
0,
9,
0,
0,
0,
0,
0,
0,
0,
9,
10,
10,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
2,
2,
0
] |
7075 | [
"Copyright",
"1999",
"Academic",
"Press",
"."
] | [
0,
0,
0,
0,
0
] |
13186 | [
"Relative",
"levels",
"were",
"then",
"correlated",
"with",
"a",
"series",
"of",
"clinical",
"variables",
"including",
"response",
"to",
"therapy",
",",
"performance",
"status",
",",
"survival",
",",
"disease",
"sites",
",",
"age",
",",
"and",
"others",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
12065 | [
"Furthermore",
",",
"TIMP-1",
"upregulation",
"induced",
"expression",
"of",
"Bcl-XL",
"but",
"not",
"Bcl-2",
"as",
"well",
"as",
"decreased",
"NF-kappaB",
"activity",
"as",
"compared",
"with",
"controls",
"."
] | [
0,
0,
9,
0,
0,
0,
0,
9,
0,
0,
9,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0
] |
14495 | [
"The",
"transactivator",
"HTLV-I",
"Tax",
"activates",
"the",
"promoter",
"of",
"the",
"gene",
"coding",
"for",
"the",
"interleukin",
"2",
"alpha-chain",
"receptor",
"(",
"IL-2R",
"alpha",
")",
"via",
"a",
"kappa",
"B",
"site",
"that",
"can",
"bind",
"several",
"protein",
"species",
"of",
"the",
"rel",
"family",
"."
] | [
0,
0,
9,
10,
0,
0,
1,
0,
0,
0,
0,
0,
0,
9,
10,
10,
10,
0,
9,
10,
0,
0,
0,
1,
2,
2,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
0
] |
1801 | [
"The",
"GM-kappa",
"B",
"sequence",
"is",
"recognized",
"by",
"NF-kappa",
"B",
",",
"which",
"is",
"mainly",
"induced",
"by",
"PMA",
"."
] | [
0,
1,
2,
2,
0,
0,
0,
9,
10,
0,
0,
0,
0,
0,
0,
0,
0
] |
1358 | [
"Posttranscriptional",
"regulation",
"of",
"macrophage",
"tissue",
"factor",
"expression",
"by",
"antioxidants",
"."
] | [
0,
0,
0,
0,
9,
10,
0,
0,
0,
0
] |
13394 | [
"It",
"has",
"been",
"proposed",
"that",
"the",
"cross-priming",
"of",
"CTL",
"responses",
"in",
"vivo",
"involves",
"the",
"transfer",
"to",
"host",
"APCs",
"of",
"heat",
"shock",
"protein",
"glycoprotein",
"96",
"-chaperoned",
"antigenic",
"peptides",
"released",
"from",
"the",
"endoplasmic",
"reticulum",
"(",
"ER",
")",
"of",
"dying",
"or",
"infected",
"cells",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
7,
0,
9,
10,
10,
10,
10,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
7,
8,
8,
8,
0
] |
2207 | [
"Reverse",
"transcriptase-polymerase",
"chain",
"reaction",
"was",
"used",
"to",
"examine",
"HB9",
"RNA",
"transcripts",
"in",
"hematopoietic",
"cell",
"lines",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
3,
4,
4,
0,
5,
6,
6,
0
] |
10788 | [
"However",
",",
"the",
"progression",
"to",
"subsequent",
"events",
"which",
"comprise",
"terminal",
"differentiation",
"and",
"cell",
"cycle",
"arrest",
"is",
"halted",
"during",
"the",
"adaptation",
"to",
"the",
"presence",
"of",
"1",
",",
"25D3",
"in",
"these",
"cells",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
10421 | [
"Opposite",
"effects",
"of",
"the",
"acute",
"promyelocytic",
"leukemia",
"PML-retinoic",
"acid",
"receptor",
"alpha",
"(",
"RAR",
"alpha",
")",
"and",
"PLZF-RAR",
"alpha",
"fusion",
"proteins",
"on",
"retinoic",
"acid",
"signalling",
"."
] | [
0,
0,
0,
0,
9,
10,
10,
10,
10,
10,
10,
0,
9,
10,
0,
0,
9,
10,
10,
10,
0,
0,
0,
0,
0
] |
8339 | [
"The",
"overlapping",
"expression",
"patterns",
"and",
"similar",
"in",
"vitro",
"binding",
"and",
"trans-activation",
"activities",
"on",
"various",
"promoter",
"elements",
"of",
"NF-AT-regulated",
"genes",
"suggest",
"some",
"redundancy",
"in",
"the",
"function",
"of",
"these",
"proteins",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
0,
1,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
8939 | [
"We",
"evaluated",
"two",
"cytokine",
"systems",
",",
"IL-2",
"and",
"IFNgamma",
",",
"and",
"demonstrate",
"that",
"Nmi",
"augments",
"STAT",
"-mediated",
"transcription",
"in",
"response",
"to",
"these",
"cytokines",
"."
] | [
0,
0,
0,
0,
0,
0,
9,
0,
9,
0,
0,
0,
0,
9,
0,
9,
0,
0,
0,
0,
0,
0,
9,
0
] |
14760 | [
"Antibody",
"cross-linking",
"of",
"TR55",
",",
"in",
"the",
"absence",
"of",
"exogenous",
"TNF-alpha",
",",
"induced",
"maximal",
"HIV-1",
"expression",
",",
"an",
"up-modulation",
"of",
"surface",
"TR75",
",",
"and",
"nuclear",
"NF-kappa",
"B",
"activity",
"in",
"OM-10.1",
"cultures",
"."
] | [
0,
0,
0,
9,
0,
0,
0,
0,
0,
9,
10,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
0,
0,
9,
10,
0,
0,
0,
0,
0
] |
8746 | [
"We",
"also",
"showed",
"that",
"tumor",
"necrosis",
"factor",
"(",
"TNF",
")",
"and",
"to",
"a",
"lesser",
"extent",
"interleukin-1",
"(",
"IL-1",
")",
",",
"secreted",
"within",
"the",
"coculture",
",",
"induce",
"NF-kappaB",
"activity",
"and",
"a",
"correlative",
"LTR",
"transactivation",
"."
] | [
0,
0,
0,
0,
9,
10,
10,
0,
9,
0,
0,
0,
0,
0,
0,
9,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
1,
0,
0
] |
3392 | [
"After",
"a",
"2-day",
"incubation",
"in",
"LDL",
",",
"the",
"binding",
"of",
"NF-kappa",
"B",
",",
"which",
"is",
"believed",
"to",
"be",
"a",
"key",
"oxidative-stress",
"sensor",
"for",
"VCAM",
"regulation",
",",
"remains",
"at",
"basal",
"level",
"."
] | [
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
9,
10,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0
] |
198 | [
"These",
"data",
"suggest",
"that",
"while",
"GATA-1",
"can",
"transactivate",
"the",
"EpoR",
"promoter",
",",
"the",
"level",
"of",
"hEpoR",
"gene",
"expression",
"does",
"not",
"depend",
"on",
"GATA-1",
"alone",
"."
] | [
0,
0,
0,
0,
0,
9,
0,
0,
0,
1,
2,
0,
0,
0,
0,
1,
2,
0,
0,
0,
0,
0,
9,
0,
0
] |
17689 | [
"In",
"this",
"manner",
",",
"the",
"paired",
"box",
"containing",
"gene",
"Pax-5",
",",
"encoding",
"the",
"B",
"cell",
"specific",
"transcription",
"factor",
"BSAP",
",",
"has",
"been",
"shown",
"to",
"play",
"a",
"key",
"role",
"in",
"early",
"B",
"lymphopoiesis",
"."
] | [
0,
0,
0,
0,
0,
1,
2,
2,
2,
1,
0,
0,
0,
9,
10,
10,
10,
10,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
13377 | [
"YM268",
"and",
"pioglitazone",
"dose-dependently",
"increased",
"the",
"2-deoxyglucose",
"uptake",
"in",
"3T3-L1",
"cells",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
5,
6,
0
] |
8559 | [
"Following",
"integration",
"into",
"the",
"host",
"cell",
"genome",
",",
"HTLV-I",
"replication",
"is",
"regulated",
"by",
"both",
"host",
"and",
"viral",
"mechanisms",
"that",
"control",
"transcription",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
15430 | [
"The",
"human",
"IL-4",
"gene",
",",
"of",
"10",
"kilobases",
",",
"is",
"composed",
"of",
"four",
"exons",
"and",
"three",
"introns",
"."
] | [
0,
1,
2,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
0,
0,
1,
0
] |
39 | [
"In",
"coimmunoprecipitation",
"experiments",
"using",
"transfected",
"COS",
"cells",
",",
"GATA-1",
"and",
"ER",
"associate",
"in",
"a",
"ligand-dependent",
"manner",
"."
] | [
0,
0,
0,
0,
0,
5,
6,
0,
9,
0,
9,
0,
0,
0,
0,
0,
0
] |
15003 | [
"Induction",
"by",
"hemin",
"increases",
",",
"while",
"induction",
"with",
"12-O-tetradecanoylphorbol-13-acetate",
"(",
"TPA",
")",
"represses",
",",
"erythroid-specific",
"gene",
"expression",
"in",
"the",
"human",
"cell",
"line",
"K562",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
0,
0,
0,
5,
6,
6,
6,
0
] |
292 | [
"In",
"this",
"report",
"we",
"demonstrate",
"that",
"IL-12",
"induces",
"tyrosine",
"phosphorylation",
"of",
"a",
"recently",
"identified",
"STAT",
"family",
"member",
",",
"STAT4",
",",
"and",
"show",
"that",
"STAT4",
"expression",
"is",
"regulated",
"by",
"T-cell",
"activation",
"."
] | [
0,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
9,
10,
10,
0,
9,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0
] |
12284 | [
"We",
"previously",
"reported",
"that",
"monocyte",
"adhesion",
"to",
"tumor",
"necrosis",
"factor-alpha",
"(",
"TNF-alpha",
")",
"-treated",
"endothelial",
"cells",
"increased",
"expression",
"of",
"tissue",
"factor",
"and",
"CD36",
"on",
"monocytes",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
5,
6,
6,
6,
6,
6,
6,
6,
6,
0,
0,
0,
0,
0,
0,
9,
0,
0,
0
] |
7172 | [
"CONCLUSIONS",
":",
"Substantial",
"growth",
"inhibition",
"and",
"apoptosis",
"without",
"evidence",
"of",
"differentiation",
"were",
"induced",
"in",
"most",
"malignant",
"lymphocytic",
"cells",
"treated",
"with",
"1-2",
"microM",
"As2O3",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
7,
8,
8,
0,
0,
0,
0,
0,
0
] |
5030 | [
"Although",
"GABP",
"expression",
"is",
"not",
"restricted",
"to",
"the",
"hematopoietic",
"lineage",
",",
"its",
"interaction",
"with",
"other",
"specific",
"factors",
"may",
"contribute",
"to",
"the",
"tissue-specific",
"expression",
"of",
"the",
"gammac",
"gene",
"."
] | [
0,
9,
0,
0,
0,
0,
0,
0,
7,
8,
0,
0,
0,
0,
0,
9,
10,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
0
] |
86 | [
"We",
"demonstrate",
",",
"through",
"the",
"deletion",
"of",
"the",
"human",
"UDG",
"promoter",
"sequences",
",",
"that",
"expression",
"of",
"E2F-1",
"activates",
"the",
"UDG",
"promoter",
"through",
"several",
"E2F",
"sites",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
2,
2,
0,
0,
0,
0,
9,
0,
0,
1,
2,
0,
0,
1,
2,
0
] |
13504 | [
"Altered",
"DNA-binding",
"specificity",
"mutants",
"of",
"EKLF",
"and",
"Sp1",
"show",
"that",
"EKLF",
"is",
"an",
"activator",
"of",
"the",
"beta-globin",
"locus",
"control",
"region",
"in",
"vivo",
"."
] | [
9,
10,
10,
10,
0,
9,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
1,
2,
2,
2,
0,
0,
0
] |
11977 | [
"None",
"of",
"the",
"substitutions",
"in",
"the",
"ligand-binding",
"domain",
"matched",
"mutations",
"known",
"to",
"influence",
"binding",
"affinity",
"in",
"other",
"species",
"."
] | [
0,
0,
0,
0,
0,
0,
9,
10,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
17295 | [
"We",
"demonstrate",
"that",
"the",
"NF-microB-binding",
"site",
"plays",
"a",
"critical",
"role",
"in",
"the",
"IgH",
"enhancer",
",",
"because",
"mutation",
"of",
"the",
"microB",
"DNA",
"motif",
"decreased",
"transcriptional",
"activity",
"of",
"the",
"IgH",
"enhancer",
"in",
"cells",
"of",
"the",
"B-cell",
"lineage",
"but",
"not",
"in",
"nonlymphoid",
"cells",
"."
] | [
0,
0,
0,
0,
1,
2,
0,
0,
0,
0,
0,
0,
1,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
0,
0,
0,
0,
7,
8,
0,
0,
0,
7,
8,
0
] |
504 | [
"Yet",
",",
"the",
"levels",
"of",
"the",
"activating",
"NF-AT",
"complex",
"never",
"reach",
"those",
"observed",
"in",
"similarly",
"stimulated",
"normal",
"T",
"cells",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
9,
10,
0,
0,
0,
0,
0,
0,
0,
0,
7,
8,
0
] |
3638 | [
"E3",
"transcripts",
"were",
"RA-inducible",
"in",
"HL60",
"cells",
",",
"but",
"not",
"in",
"an",
"RA-resistant",
"subclone",
",",
"HL60R",
",",
"that",
"harbors",
"a",
"mutated",
"RAR",
"alpha",
"gene",
"."
] | [
9,
10,
0,
0,
0,
5,
6,
0,
0,
0,
0,
0,
5,
6,
0,
5,
0,
0,
0,
0,
0,
1,
2,
2,
0
] |
12872 | [
"Regulation",
"of",
"the",
"vitellogenin",
"gene",
"B1",
"promoter",
"after",
"transfer",
"into",
"hepatocytes",
"in",
"primary",
"cultures",
"."
] | [
0,
0,
0,
1,
2,
2,
2,
0,
0,
0,
7,
0,
0,
0,
0
] |
16205 | [
"This",
"induction",
"of",
"CAT",
"activity",
"was",
"sensitive",
"to",
"dexamethasone",
"."
] | [
0,
0,
0,
9,
0,
0,
0,
0,
0,
0
] |
9625 | [
"As",
"cortisol",
"is",
"involved",
"in",
"the",
"physiological",
"regulation",
"of",
"cytokines",
",",
"a",
"study",
"was",
"conducted",
"to",
"examine",
"cytokine",
"patterns",
"in",
"two",
"groups",
"of",
"hypercortisolemic",
"patients",
",",
"one",
"with",
"normal",
"sensitivity",
"to",
"glucocorticoids",
"and",
"the",
"other",
"with",
"glucocorticoid",
"resistance",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
3501 | [
"The",
"mean",
"concentrations",
"necessary",
"to",
"cause",
"50",
"%",
"inhibition",
"of",
"lymphocyte",
"proliferation",
"(",
"IC50s",
")",
"for",
"the",
"steroid-sensitive",
"group",
"ranged",
"from",
"2",
"x",
"10",
"(",
"-10",
")",
"mol/L",
"for",
"budesonide",
"to",
"7",
"x",
"10",
"(",
"-8",
")",
"mol/L",
"for",
"hydrocortisone",
",",
"whereas",
"the",
"mean",
"IC50s",
"for",
"the",
"steroid-resistant",
"group",
"ranged",
"from",
"approximately",
"2",
"x",
"10",
"(",
"-8",
")",
"mol/L",
"for",
"budesonide",
"to",
"greater",
"than",
"10",
"(",
"-6",
")",
"mol/L",
"for",
"hydrocortisone",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
10017 | [
"Interferons",
"exert",
"their",
"antiviral",
",",
"antiproliferative",
"and",
"immunoregulatory",
"activities",
"by",
"stimulating",
"the",
"expression",
"of",
"several",
"genes",
"."
] | [
9,
0,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
5917 | [
"Circulating",
"dendritic",
"cells",
"(",
"DC",
")",
"are",
"phenotypically",
"and",
"functionally",
"identical",
"with",
"normal",
"peripheral",
"blood",
"(",
"PB",
")",
"DC",
"."
] | [
7,
8,
8,
0,
7,
0,
0,
0,
0,
0,
0,
0,
7,
8,
8,
8,
8,
8,
8,
0
] |
3058 | [
"The",
"current",
"study",
"examined",
"whether",
"alterations",
"in",
"glucocorticoid",
"receptor",
"(",
"GR",
")",
"binding",
"contribute",
"to",
"poor",
"response",
"to",
"glucocorticoid",
"therapy",
"in",
"asthma",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
9,
10,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
14772 | [
"A",
"reporter",
"gene",
"under",
"the",
"control",
"of",
"a",
"T-cell",
"antigen",
"receptor",
"element",
"was",
"activated",
"in",
"Jurkat",
"cells",
"by",
"antigen",
"receptor",
"triggering",
"or",
"by",
"a",
"combination",
"of",
"phorbol",
"myristate",
"acetate",
",",
"which",
"activates",
"protein",
"kinase",
"C",
",",
"and",
"a",
"calcium",
"ionophore",
"."
] | [
0,
1,
2,
0,
0,
0,
0,
0,
1,
2,
2,
2,
0,
0,
0,
5,
6,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
10,
0,
0,
0,
0,
0,
0
] |
13958 | [
"To",
"elucidate",
"the",
"contributions",
"of",
"GATA-1",
"to",
"definitive",
"hematopoiesis",
"in",
"vivo",
",",
"we",
"have",
"examined",
"adult",
"mice",
"that",
"were",
"rendered",
"genetically",
"defective",
"in",
"GATA-1",
"synthesis",
"(",
"Takahashi",
"et",
"al",
",",
"J",
"Biol",
"Chem",
"272",
":",
"12611",
",",
"1997",
")",
"."
] | [
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
17733 | [
"Results",
"indicated",
"that",
"(",
"i",
")",
"constitutive",
"c-fos",
"transcript",
"levels",
"are",
"significantly",
"higher",
"in",
"patients",
"subsequently",
"responding",
"to",
"IFN-alpha",
"therapy",
"(",
"p",
"<",
"0.01",
")",
"and",
"positively",
"correlated",
"with",
"the",
"proportion",
"of",
"lymphocytes",
"(",
"r",
"=",
"0.6895",
",",
"p",
"<",
"0.01",
")",
"and",
"negatively",
"with",
"the",
"proportion",
"of",
"immature",
"cells",
"(",
"r",
"=",
"-0.568",
",",
"p",
"<",
"0.01",
")",
"contained",
"in",
"the",
"pbmc",
"preparations",
"tested",
",",
"(",
"ii",
")",
"constitutive",
"mRNA",
"levels",
"of",
"the",
"hybrid",
"bcr/abl",
",",
"c-myc",
"and",
"p53",
"are",
"positively",
"correlated",
"with",
"each",
"other",
",",
"but",
"failed",
"to",
"relate",
"to",
"disease",
"parameters",
",",
"and",
"(",
"iii",
")",
"acute",
"and",
"chronic",
"in",
"vivo",
"exposure",
"to",
"IFN-alpha",
"is",
"accompanied",
"by",
"upregulation",
"of",
"c-fos",
"and",
"downregulation",
"of",
"c-myc",
"mRNA",
"levels",
"in",
"responder",
"patients",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
3,
4,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
7,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
7,
8,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
7,
0,
0,
0,
0,
0,
0,
3,
4,
0,
0,
0,
1,
2,
0,
1,
0,
1,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
1,
0,
0,
0,
3,
4,
0,
0,
0,
0,
0
] |
2619 | [
"Taken",
"together",
",",
"these",
"results",
"demonstrate",
"that",
"tolerance",
"to",
"LPS",
"is",
"determined",
"by",
"post-receptor",
"mechanisms",
"that",
"involve",
"an",
"altered",
"composition",
"of",
"the",
"NF-kappa",
"B",
"complex",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
10,
0
] |
15624 | [
"Low",
"dose",
"dexamethasone",
"therapy",
"(",
"1-1.5",
"mg/day",
")",
"was",
"of",
"clinical",
"benefit",
"in",
"these",
"patients",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
10201 | [
"Ad2",
"infection",
"induced",
"transient",
"increase",
"in",
"the",
"mRNA",
"levels",
"for",
"TNF-alpha",
"and",
"IL-1",
"beta",
"in",
"both",
"monocytes",
"and",
"in",
"macrophages",
",",
"although",
"the",
"kinetics",
"of",
"the",
"transcription",
"was",
"slightly",
"different",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
3,
0,
0,
9,
0,
9,
10,
0,
0,
7,
0,
0,
7,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
8622 | [
"Although",
"no",
"germ-line",
"BRCA1",
"mutation",
"was",
"observed",
",",
"6",
"of",
"the",
"18",
"male",
"breast",
"cancer",
"cases",
"(",
"33",
"%",
")",
"carried",
"truncating",
"mutations",
"in",
"the",
"BRCA2",
"gene",
"."
] | [
0,
0,
0,
1,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
0,
0
] |
6848 | [
"Through",
"systematic",
"DNA",
"footprinting",
"of",
"the",
"TNF",
"(",
"encoding",
"tumour",
"necrosis",
"factor",
",",
"TNF",
")",
"promoter",
"region",
",",
"we",
"have",
"identified",
"a",
"single",
"nucleotide",
"polymorphism",
"(",
"SNP",
")",
"that",
"causes",
"the",
"helix-turn-helix",
"transcription",
"factor",
"OCT-1",
"to",
"bind",
"to",
"a",
"novel",
"region",
"of",
"complex",
"protein-DNA",
"interactions",
"and",
"alters",
"gene",
"expression",
"in",
"human",
"monocytes",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
7,
8,
0
] |
14616 | [
"Although",
"the",
"assay",
"involves",
"the",
"dramatic",
"loss",
"of",
"red",
"cell",
"production",
",",
"it",
"should",
"be",
"possible",
"to",
"define",
"important",
"regulatory",
"domains",
"that",
"can",
"then",
"be",
"assayed",
"using",
"less",
"stringent",
"systems",
",",
"such",
"as",
"cell-free",
"extracts",
"for",
"in",
"vitro",
"transcription",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
636 | [
"From",
"these",
"cellular",
"changes",
",",
"we",
"can",
"infer",
"that",
"the",
"cell",
"growth",
"was",
"modulated",
"along",
"with",
"induction",
"of",
"terminal",
"differentiation",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
11457 | [
"In",
"the",
"present",
"study",
",",
"we",
"have",
"utilized",
"a",
"mutant",
"Jak1-deficient",
"HeLa",
"cell",
"line",
",",
"E1C3",
",",
"and",
"its",
"parental",
"Jak1-expressing",
"counterpart",
",",
"1D4",
",",
"to",
"analyze",
"the",
"role",
"of",
"Jak1",
"in",
"mediating",
"IL-4-induced",
"tyrosine",
"phosphorylation",
"events",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
5,
6,
6,
6,
6,
0,
5,
0,
0,
0,
5,
6,
6,
0,
5,
0,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0
] |
6998 | [
"The",
"pattern",
"of",
"kappaB",
"-binding",
"activity",
"in",
"T",
"cells",
"of",
"RCC",
"patient",
"was",
"altered",
"as",
"compared",
"to",
"that",
"seen",
"in",
"T",
"cells",
"obtained",
"from",
"normal",
"volunteers",
"."
] | [
0,
0,
0,
9,
0,
0,
0,
7,
8,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
7,
8,
0,
0,
0,
0,
0
] |
17334 | [
"In",
"an",
"exploration",
"of",
"the",
"potential",
"role",
"of",
"the",
"glucocorticoid",
"receptor",
"(",
"GR",
")",
"in",
"AD",
",",
"GR",
"density",
"and",
"affinity",
"were",
"assessed",
"on",
"mononuclear",
"leukocytes",
"of",
"12",
"AD",
"patients",
"and",
"12",
"healthy",
"controls",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
7,
8,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
4486 | [
"Granulocyte-macrophage",
"colony-stimulating",
"factor",
"(",
"GM-CSF",
")",
"induces",
"immediate",
"effects",
"in",
"monocytes",
"by",
"activation",
"of",
"the",
"Janus",
"kinase",
"(",
"JAK2",
")",
"and",
"STAT",
"transcription",
"factor",
"(",
"STAT5",
")",
"pathway",
"."
] | [
9,
10,
10,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
0,
9,
0,
0,
9,
10,
10,
0,
9,
0,
0,
0
] |
2885 | [
"The",
"regulatory",
"role",
"of",
"protein",
"tyrosine",
"phosphatases",
"(",
"PTPases",
")",
"in",
"this",
"process",
"was",
"explored",
"by",
"studying",
"the",
"effects",
"of",
"a",
"powerful",
"PTPase",
"inhibitor",
",",
"vanadate",
"peroxide",
"(",
"pervanadate",
")",
",",
"on",
"the",
"activation",
"cascade",
"of",
"Jurkat",
"human",
"leukaemic",
"T-cells",
"."
] | [
0,
0,
0,
0,
9,
10,
10,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
5,
6,
6,
6,
0
] |
17031 | [
"Nuclear",
"T3R",
"in",
"lymphocytes",
"was",
"determined",
"by",
"radio-ligand",
"binding",
"analysis",
"."
] | [
0,
9,
0,
7,
0,
0,
0,
0,
0,
0,
0
] |
15608 | [
"By",
"virtue",
"of",
"the",
"presence",
"of",
"CD4",
"on",
"the",
"cell",
"surface",
",",
"PLB-985",
"cells",
"were",
"chronically",
"infected",
"with",
"HIV-1",
"strain",
"IIIB",
"."
] | [
0,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
5,
6,
0,
0,
0,
0,
0,
0,
0,
0
] |
Subsets and Splits