Datasets:
siddharthtumre
/
jnlpba-split

Dataset card Data Studio Files Community
id
stringlengths
1
5
tokens
sequence
ner_tags
sequence
8002
[ "The", "plasma", "ANH", "level", "was", "38", "pmol/l", "(", "N", "supine", ":", "5-25", ")", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
11105
[ "There", "appears", "to", "be", "no", "relationship", "between", "the", "number", "of", "AML1/ETO", "transcripts", "found", "in", "the", "infused", "PBSC", "harvests", "and", "the", "incidence", "of", "leukemic", "relapse", "following", "autologous", "PBSCT", "in", "our", "study", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 4, 0, 0, 0, 0, 7, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
12090
[ "During", "fetal", "development", ",", "it", "is", "required", "at", "the", "earliest", "stage", "of", "T", "cell", "and", "B", "cell", "specification", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
13125
[ "ICAM-1", "and", "CD71", "are", "nevertheless", "up-regulated", "by", "LMP1", "in", "primary", "B", "cells", "and", "cell", "lines", "expressing", "the", "dominant", "IkappaB", "." ]
[ 9, 0, 9, 0, 0, 0, 0, 9, 0, 7, 8, 8, 0, 0, 0, 0, 0, 9, 10, 0 ]
1941
[ "The", "anti-inflammatory", "drugs", "sodium", "salicylate", "and", "aspirin", "inhibited", "the", "activation", "of", "NF-kappa", "B", ",", "which", "further", "explains", "the", "mechanism", "of", "action", "of", "these", "drugs", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
3840
[ "The", "downstream", "regulatory", "region", "contains", "a", "cyclic", "AMP-responsive", "element", "(", "CRE", ")", "." ]
[ 0, 0, 0, 0, 0, 0, 1, 2, 2, 0, 1, 0, 0 ]
12192
[ "This", "review", "will", "concentrate", "on", "this", "topic", "and", "on", "its", "role", "for", "the", "regulation", "of", "eosinophil", "apoptosis", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
5627
[ "Collectively", ",", "a", "unique", "mechanism", "involving", "NF-ATp", "appears", "to", "regulate", "the", "cell", "type-specific", "and", "activation-dependent", "expression", "of", "the", "SCM-1", "genes", "." ]
[ 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0 ]
8189
[ "In", "contrast", ",", "in", "the", "more", "immature", ",", "multipotent", "EML", "cells", "we", "observed", "that", "this", "RXR", "-specific", "agonist", "is", "inactive", "either", "in", "potentiating", "IL-3", "-mediated", "commitment", "of", "EML", "cells", "to", "the", "granulocyte", "lineage", "or", "in", "transactivating", "RAR-RXR", "response", "elements", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 7, 8, 0, 0, 7, 8, 0, 0, 0, 1, 2, 2, 0 ]
16353
[ "Northern", "blot", "experiments", "demonstrate", "further", "that", "TCF-1", "alpha", "mRNA", "is", "highly", "tissue", "specific", ",", "found", "primarily", "in", "the", "thymus", "or", "T", "cell", "lines", "." ]
[ 0, 0, 0, 0, 0, 0, 3, 4, 4, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 6, 6, 6, 6, 0 ]
5378
[ "More", "is", "known", "regarding", "signal", "transduction", "events", "that", "occur", "after", "ligation", "of", "the", "T-cell", "antigen", "receptor", "(", "TCR", ")", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 9, 0, 0 ]
2419
[ "We", "observed", "that", "RA", "did", "not", "induced", "neutrophil", "differentiation", "in", "serum-free", "grown", "HL60", "cells", "whereas", "50", "nM", "1", "alpha", ",", "25-dihydroxyvitamin", "D3", "(", "D3", ")", "induced", "maximal", "monocyte", "differentiation", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 6, 6, 6, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
4058
[ "Thus", ",", "this", "work", "presents", "the", "first", "detailed", "analysis", "of", "a", "naturally", "occurring", "mutation", "in", "a", "basal", "transcription", "factor", "and", "supports", "the", "concept", "that", "the", "combined", "XP/CS", "clinical", "entity", "is", "actually", "the", "result", "of", "a", "combined", "transcription/repair", "deficiency", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
6368
[ "IkappaB", "further", "reduces", "the", "translocation", "of", "NF-kappaB", "into", "the", "nucleus", "thus", "preventing", "the", "expression", "of", "proinflammatory", "genes", "." ]
[ 9, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0 ]
13421
[ "These", "observations", "demonstrate", "that", "CD4", "signaling", "mediates", "HIV-induced", "apoptosis", "by", "a", "mechanism", "independent", "of", "Fas", "-Fas", "ligand", "interaction", ",", "does", "not", "require", "p56", "(", "lck", ")", "signaling", ",", "and", "may", "involve", "a", "critical", "region", "for", "CD4", "dimerization", "." ]
[ 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 9, 10, 0, 0, 0, 0, 0, 9, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0 ]
13869
[ "Crkl", ",", "an", "SH2/SH3", "adapter", "protein", ",", "becomes", "coimmunoprecipitated", "specifically", "with", "STAT5", "from", "erythropoietin-stimulated", "erythroid", "cells", ";", "although", "it", "was", "shown", "to", "become", "associated", "with", "c-Cbl", "in", "the", "studies", "using", "cell", "lines", "." ]
[ 9, 0, 0, 9, 10, 10, 0, 0, 0, 0, 0, 9, 0, 7, 8, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 5, 6, 0 ]
9415
[ "Ctx", "combined", "with", "TNFalpha", "or", "IL-1beta", "to", "produce", "a", "synergistic", "increase", "in", "p24", "antigen", "production", "in", "U1", "promonocytic", "cells", "." ]
[ 9, 0, 0, 9, 0, 9, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 5, 6, 6, 0 ]
18144
[ "Functional", "specificity", "for", "repression", "matches", "the", "DNA", "binding", "specificity", "of", "complex", "3", ";", "both", "repressor", "activity", "and", "complex", "3", "binding", "require", "the", "consensus", "sequence", "CTCACNTNC", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 1, 2, 0, 0 ]
14875
[ "Southern", "blot", "analysis", "of", "in", "situ", "lysing", "gels", "revealed", "that", "the", "cellular", "content", "of", "linear", "EBV", "DNA", "was", "also", "increased", "significantly", "after", "the", "initiation", "of", "the", "viral", "lytic", "cycle", ",", "while", "the", "amount", "of", "circular", "DNA", "remained", "approximately", "constant", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
10076
[ "Our", "results", "demonstrate", "that", "short-term", "incubation", "of", "these", "cells", "with", "oxLDL", "activated", "p50/p65", "containing", "NF-kappa", "B", "dimers", "and", "induced", "the", "expression", "of", "the", "target", "gene", "IL-8", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 9, 10, 10, 0, 0, 0, 0, 0, 0, 1, 2, 2, 0 ]
5148
[ "The", "role", "of", "alterations", "of", "the", "MTS1", "tumor", "suppressor", "gene", "on", "chromosome", "9p21", ",", "which", "encodes", "p16", ",", "the", "inhibitor", "of", "cyclin-dependent-kinase-4", "and", "6", ",", "in", "tumorigenesis", "is", "not", "yet", "clear", "." ]
[ 0, 0, 0, 0, 0, 0, 1, 2, 2, 2, 0, 1, 2, 0, 0, 0, 9, 0, 0, 0, 0, 9, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0 ]
1683
[ "Functional", "analysis", "of", "the", "promoter", "1", "with", "a", "transient", "expression", "assay", "using", "chloramphenicol", "acetyltransferase", "(", "CAT", ")", "gene", "as", "a", "reporter", "showed", "that", "both", "PAF", "and", "TPA", "activated", "the", "promoter", "1", "but", "not", "the", "deleted", "promoter", "lacking", "the", "three", "consensus", "binding", "sites", "for", "NF-kappa", "B", "located", "from", "-571", "bp", "to", "-459", "bp", "." ]
[ 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 1, 2, 2, 2, 2, 2, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0 ]
10361
[ "The", "glucocorticoid", "receptor", "was", "able", "to", "further", "enhance", "IL-4", "-induced", "gene", "transcription", "through", "the", "action", "of", "Stat6", "." ]
[ 0, 9, 10, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 9, 0 ]
2001
[ "Both", "LAM", "-and", "LPS-inducible", "IL-6", "promoter", "activity", "was", "localized", "to", "a", "DNA", "fragment", ",", "positions", "-158", "to", "-49", ",", "by", "deletion", "analysis", "and", "chloramphenicol", "acetyltransferase", "assay", "." ]
[ 0, 9, 0, 1, 2, 2, 0, 0, 0, 0, 0, 1, 2, 0, 0, 1, 2, 2, 0, 0, 0, 0, 0, 9, 10, 0, 0 ]
3164
[ "Furthermore", ",", "PU.1", "transactivates", "the", "M-CSF", "receptor", "promoter", "in", "nonmacrophage", "cells", "." ]
[ 0, 0, 9, 0, 0, 1, 2, 2, 0, 7, 8, 0 ]
5685
[ "Atopy", ",", "which", "predisposes", "individuals", "to", "develop", "asthma", ",", "severe", "systemic", "anaphylaxis", ",", "and", "atopic", "dermatitis", ",", "is", "usually", "associated", "with", "dramatically", "elevated", "total", "serum", "IgE", "levels", "and", "is", "thought", "to", "be", "controlled", "by", "a", "major", "susceptibility", "gene", "and", "multiple", "minor", "susceptibility", "genes", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 1, 2, 0 ]
13484
[ "OBJECTIVE", ":", "We", "hypothesized", "that", "in", "extrinsic", "asthma", "or", "in", "cases", "of", "markedly", "elevated", "IgE", "(", "ie", ",", "hyperimmunoglobulin", "E", "[", "HIE", "]", ")", "increased", "levels", "of", "IgE", "may", "be", "associated", "with", "alterations", "in", "the", "cytokine", "levels", "or", "the", "activation", "of", "Stat6", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 9, 0 ]
3402
[ "Although", "inhibition", "of", "IL-4-driven", "germline", "C", "epsilon", "transcription", "by", "NAC", "was", "not", "sufficient", ",", "the", "agent", "remarkably", "diminished", "anti-CD40", "mAb", "-mediated", "up-regulation", "of", "germline", "C", "epsilon", "transcription", "." ]
[ 0, 0, 0, 5, 6, 6, 6, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 1, 0, 0, 0, 0 ]
16514
[ "Kappa", "B", "binding", "proteins", "are", "constitutively", "expressed", "in", "an", "IL-2", "autocrine", "human", "T", "cell", "line", "." ]
[ 9, 10, 10, 10, 0, 0, 0, 0, 0, 5, 6, 6, 6, 6, 6, 0 ]
14269
[ "Furthermore", ",", "68", "triple-labellings", "with", "mAbs", "were", "performed", "on", "the", "cells", "of", "each", "volunteer", "to", "possibly", "generate", "further", "hypotheses", "." ]
[ 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
3479
[ "We", "found", "a", "correlation", "between", "the", "uptake", "of", "dexamethasone", "by", "the", "ghost", "membranes", "and", "the", "decrease", "in", "the", "structural", "order", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
3570
[ "We", "here", "summarize", "evidence", "that", "thymic", "atrophy", "induced", "by", "2", ",", "3", ",", "7", ",", "8-tetrachlorodibenzo-p-dioxin", "(", "TCDD", ")", "can", "be", "mediated", ",", "at", "least", "in", "part", ",", "by", "damage", "to", "extrathymic", "T-cell", "precursors", "in", "bone", "marrow", "and", "fetal", "liver", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 8, 0, 0, 0, 0, 0, 0, 0 ]
15550
[ "[", "Effect", "of", "antihypertensive", "therapy", "with", "captopril", "on", "gluco-", "and", "mineralocorticoid", "receptors", "of", "peripheral", "blood", "lymphocytes", "in", "hypertensive", "patients", "of", "various", "age", "]" ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 0, 7, 8, 8, 0, 0, 0, 0, 0, 0, 0 ]
5106
[ "However", ",", "in", "the", "presence", "of", "PML-RAR", ",", "the", "synthetic", "retinoid", "is", "a", "much", "better", "transactivator", "of", "retinoic", "acid-responsive", "element-containing", "promoters", "than", "the", "natural", "retinoid", ",", "whereas", ",", "in", "the", "presence", "of", "RAR", "alpha", ",", "AM580", "and", "ATRA", "have", "similar", "activity", "." ]
[ 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0 ]
8650
[ "The", "substitution", "of", "Ile", "for", "Val", "augmented", "STAT6", "activation", ",", "proliferation", ",", "and", "transcription", "activity", "of", "the", "Iepsilon", "promoter", "by", "IL-4", ",", "whereas", "that", "of", "Arg", "for", "Gln", "did", "not", "change", "these", "IL-4", "signals", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0 ]
9230
[ "We", "now", "find", "that", "mutating", "two", "tyrosines", "to", "an", "isoleucine", "at", "the", "carboxyl", "end", "of", "the", "cytoplasmic", "tail", "cripples", "the", "ability", "of", "EBV", "to", "cause", "lymphoblastoid", "cell", "outgrowth", ",", "thereby", "marking", "a", "second", "transformation", "effector", "site", ",", "TES2", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 9, 0 ]
7035
[ "Phorbol", "ester-induced", "mononuclear", "cell", "differentiation", "is", "blocked", "by", "the", "mitogen-activated", "protein", "kinase", "kinase", "(", "MEK", ")", "inhibitor", "PD98059", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 0, 9, 0, 0, 0, 0 ]
3528
[ "Now", "we", "have", "examined", "whether", "naive", "and", "memory", "T", "lymphocytes", "differ", "in", "their", "sensitivity", "to", "ROI-mediated", "signals", "." ]
[ 0, 0, 0, 0, 0, 7, 8, 8, 8, 8, 0, 0, 0, 0, 0, 0, 0, 0 ]
9942
[ "The", "process", "of", "apoptosis", "is", "used", "to", "eliminate", "unwanted", "cells", "from", "a", "wide", "variety", "of", "organisms", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0 ]
8521
[ "These", "target", "genes", "show", "quite", "distinct", "expression", "patterns", "demonstrating", "that", "transcription", "factors", "in", "addition", "to", "Oct2", "are", "involved", "in", "their", "regulation", "." ]
[ 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0 ]
11744
[ "Examination", "of", "18", "AML", "samples", "by", "EMSA", "revealed", "the", "presence", "of", "E2F", "binding", "and", "no", "gross", "abnormalities", "were", "detected", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0 ]
8875
[ "In", "conclusion", ",", "lysoPC", "markedly", "decreases", "LPS-mediated", "TF", "expression", "of", "human", "monocytes", ",", "the", "effect", "probably", "being", "mediated", "by", "both", "transcriptional", "and", "posttranscriptional", "mechanisms", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
2747
[ "Distinct", "patterns", "of", "chromosome", "1", "abnormalities", "were", "found", "among", "the", "histologic", "types", "of", "breast", "carcinoma", "." ]
[ 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
3817
[ "This", "activation", "differed", "substantially", "from", "that", "mediated", "by", "phorbol", "12-myristate", "13-acetate", "(", "PMA", ")", "and", "Ca2+", "ionophore", "or", "produced", "by", "costimulation", "with", "antibodies", "against", "the", "T", "cell", "receptor-CD3", "complex", "and", "to", "CD28", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 9, 10, 10, 10, 0, 0, 9, 0 ]
11053
[ "To", "evaluate", "the", "physiologic", "plausibility", "of", "these", "claims", ",", "we", "compared", "the", "abundance", "of", "the", "VDR", "mRNA", "in", "peripheral", "blood", "mononuclear", "cells", "(", "PBMCs", ")", "between", "different", "VDR", "genotypes", "using", "a", "quantitative", "reverse", "transcribed", "polymerase", "chain", "reaction-based", "method", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 4, 0, 7, 8, 8, 8, 0, 7, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
104
[ "In", "addition", ",", "IL-2", "but", "not", "IL-12", "induced", "nuclear", "factors", "NF-kappa", "B", "and", "AP1", ",", "and", "regulation", "of", "the", "nuclear", "levels", "of", "these", "two", "DNA", "binding", "protein", "complexes", "is", "correlated", "with", "IFN-gamma", "and", "GM-CSF", "gene", "expression", "." ]
[ 0, 0, 0, 9, 0, 0, 9, 0, 9, 10, 9, 10, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
16342
[ "We", "therefore", "investigated", "the", "effects", "of", "cysteine", "and", "related", "thiols", "on", "HIV-1", "replication", "and", "NF-kappa", "B", "expression", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0 ]
9190
[ "Here", "we", "summarize", "the", "importance", "of", "the", "IgH", "3'LCR", "and", "its", "putative", "functional", "role", "in", "IgH", "gene", "expression", "and", "compare", "it", "with", "the", "5'LCR", "regulatory", "region", "of", "the", "human", "beta-globin", "locus", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 1, 2, 2, 0, 0, 1, 2, 2, 0 ]
3588
[ "To", "investigate", "the", "mechanisms", "of", "transcriptional", "activation", "of", "interleukin-1beta", "(", "IL-1beta", ")", "in", "non-monocytic", "cells", ",", "we", "constructed", "a", "series", "of", "reporter", "plasmids", "with", "the", "bacterial", "chloramphenicol", "acetyltransferase", "gene", "linked", "to", "various", "parts", "of", "the", "human", "IL-1beta", "promoter", "and", "performed", "transient", "transfection", "experiments", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 0, 0, 0, 0, 0, 0 ]
11790
[ "Higher-molecular-weight", "species", "of", "NFATc", "(", "of", "110", "and", "140", "kDa", ")", "were", "also", "detected", "." ]
[ 9, 10, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
10983
[ "One", "of", "the", "cDNA", "fragments", "expressed", "specifically", "in", "CD3", "-and", "CD28", "-activated", "T", "cells", "was", "designated", "RP1", "." ]
[ 0, 0, 0, 1, 2, 0, 0, 0, 9, 0, 9, 7, 8, 8, 0, 0, 1, 0 ]
6050
[ "By", "functionally", "expressing", "receptor", "mutants", "in", "the", "murine", "pro-B", "cell", "line", "Ba/F3", ",", "we", "could", "show", "that", "phosphorylated", "tyrosine", "residues", "within", "the", "IL-4R", "alpha", "chain", "are", "dispensable", "for", "IL-4", "-induced", "STAT5", "activity", "." ]
[ 0, 0, 0, 9, 10, 0, 0, 5, 6, 6, 6, 5, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 0, 0, 9, 0, 9, 0, 0 ]
8334
[ "Here", "we", "describe", "methods", "to", "investigate", "whether", "and", "how", "signaling", "agonists", "induce", "myeloid", "differentiation", "and", "how", "oncoproteins", "might", "cause", "AML", "by", "modulating", "the", "activity", "of", "transcription", "factors", "that", "are", "pivotal", "for", "normal", "myeloid", "development", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0 ]
16046
[ "ROI", "appear", "to", "serve", "as", "messengers", "mediating", "directly", "or", "indirectly", "the", "release", "of", "the", "inhibitory", "subunit", "I", "kappa", "B", "from", "NF-kappa", "B", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 9, 10, 10, 0, 9, 10, 0 ]
11678
[ "The", "greater", "selectivity", "of", "PF", ",", "compared", "with", "FK506", ",", "at", "both", "the", "molecular", "and", "cellular", "levels", "may", "prove", "advantageous", "in", "manipulating", "T", "cell", "responses", "in", "vivo", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
6572
[ "We", "have", "constructed", "an", "HIV-1", "genome", "carrying", "the", "cDNA", "of", "a", "proteolysis-resistant", "nuclear", "factor-kappaB", "inhibitor", "(", "IkappaB-alphaS32/36A", ")", "in", "the", "nef", "region", "." ]
[ 0, 0, 0, 0, 1, 2, 0, 0, 1, 0, 0, 9, 10, 10, 10, 0, 9, 0, 0, 0, 1, 2, 0 ]
1193
[ "We", "found", "that", "ALD", "induce", "a", "transient", "activation", "of", "protein", "kinase", "(", "PKC", ")", "but", "have", "no", "effect", "(", "in", "comparison", "to", "anti-CD3", "antibodies", ")", "on", "protein", "tyrosine", "phosphorylation", "nor", "on", "PCL", "gamma", "1", "tyrosine", "phosphorylation", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
1523
[ "Steel", "factor", "is", "one", "of", "the", "growth", "factors", "that", "controls", "the", "proliferation", "and", "differentiation", "of", "hematopoietic", "cells", "and", "SCL", ",", "also", "known", "as", "Tcl-5", "or", "Tal-1", ",", "is", "a", "transcription", "factor", "involved", "in", "erythropoiesis", "." ]
[ 9, 10, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0, 9, 0, 0, 0, 0, 9, 0, 9, 0, 0, 0, 9, 10, 0, 0, 0, 0 ]
5905
[ "A", "role", "for", "retinoic", "acid", "during", "neutrophil", "maturation", "has", "been", "suggested", "from", "a", "variety", "of", "sources.", "Here", "we", "present", "a", "review", "of", "the", "mechanism", "of", "retinoic", "acid", "receptor", "action", "and", "the", "major", "evidence", "showing", "that", "normal", "retinoid", "signaling", "is", "required", "for", "neutrophil", "maturation", "." ]
[ 0, 0, 0, 0, 0, 0, 7, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 0, 0 ]
6240
[ "The", "minimal", "promoter", "of", "the", "human", "B29", "gene", "is", "contained", "within", "a", "193-bp", "region", "5", "'", "of", "these", "multiple", "start", "sites", "." ]
[ 0, 0, 0, 0, 0, 1, 2, 2, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 1, 2, 2, 0 ]
16137
[ "Previously", ",", "transcription", "of", "the", "c-fos", "gene", "has", "been", "reported", "to", "be", "transactivated", "by", "the", "viral", "transcription", "factor", ",", "Tax1", "." ]
[ 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 9, 0 ]
1787
[ "The", "ERP", "protein", "contains", "a", "region", "of", "high", "homology", "with", "the", "ETS", "DNA-binding", "domain", "common", "to", "all", "members", "of", "the", "ets", "transcription", "factor/oncoprotein", "family", "." ]
[ 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 0 ]
6273
[ "Activation", "of", "N-WASP", "by", "IcsA", "unmasks", "two", "domains", "acting", "together", "in", "insertional", "actin", "polymerization", "." ]
[ 0, 0, 9, 0, 9, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0 ]
8950
[ "T", "cell", "priming", "enhances", "IL-4", "gene", "expression", "by", "increasing", "nuclear", "factor", "of", "activated", "T", "cells", "." ]
[ 0, 0, 0, 0, 1, 2, 0, 0, 0, 9, 10, 10, 10, 10, 10, 0 ]
5729
[ "These", "data", "indicate", "that", "E1A", "induces", "susceptibility", "to", "killer", "cell-induced", "lysis", "through", "sensitization", "of", "cells", "to", "injury-induced", "apoptosis", "." ]
[ 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
3094
[ "Inhibition", "of", "RANTES", "expression", "did", "not", "appear", "to", "be", "secondary", "to", "IL-2", "inhibition", "and", "required", "binding", "to", "the", "intracellular", "glucocorticoid", "receptor", "." ]
[ 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0 ]
5776
[ "Protein", "tyrosine", "kinase", "activity", ",", "NF-kappaB", "activity", ",", "and", "the", "synthesis", "of", "cytokine-specific", "mRNA", "were", "inhibited", "by", "antioxidants", "." ]
[ 9, 10, 10, 0, 0, 9, 0, 0, 0, 0, 0, 0, 3, 4, 0, 0, 0, 0, 0 ]
7018
[ "In", "functional", "studies", ",", "PML", "expression", "was", "inhibited", "by", "addition", "of", "antisense", "oligomers", "targeting", "PML", "mRNA", "(", "alpha-PML", ")", "." ]
[ 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 4, 0, 9, 0, 0 ]
1082
[ "These", "results", "demonstrate", "the", "existence", "of", "a", "triple", "autoregulatory", "loop", "in", "monocytes", "and", "macrophages", "involving", "HIV", ",", "p105", "and", "p50", ",", "and", "MAD3", ",", "with", "the", "end", "result", "of", "persistent", "NF-kappa", "B", "activation", "and", "viral", "persistence", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 0, 7, 0, 0, 0, 9, 0, 9, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
1848
[ "JNK", "is", "involved", "in", "signal", "integration", "during", "costimulation", "of", "T", "lymphocytes", "." ]
[ 9, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0 ]
15872
[ "The", "function", "of", "a", "putative", "NFAT-1", "site", "in", "the", "human", "immunodeficiency", "virus", "type", "1", "enhancer", "has", "been", "analyzed", "." ]
[ 0, 0, 0, 0, 1, 2, 2, 0, 0, 1, 2, 2, 2, 2, 2, 0, 0, 0, 0 ]
16623
[ "It", "suggested", "that", "increase", "of", "ER", "levels", "play", "an", "important", "role", "in", "the", "pathogenesis", "of", "gynecomastia", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
3172
[ "RESULTS", "." ]
[ 0, 0 ]
5238
[ "Stimulation", "of", "the", "cAMP-dependent", "signaling", "pathway", "exerts", "an", "inhibitory", "effect", "on", "the", "proliferation", "and", "effector", "functions", "of", "T", "cells", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0 ]
10623
[ "Biosynthesis", "of", "tumor", "necrosis", "factor-alpha", "(", "TNF-alpha", ")", "is", "predominantly", "by", "cells", "of", "the", "monocytic", "lineage", "." ]
[ 0, 0, 9, 10, 10, 0, 9, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0 ]
5608
[ "However", ",", "the", "mechanism", "by", "which", "IFNs", "mediate", "this", "inhibition", "has", "not", "been", "defined", "." ]
[ 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0 ]
17928
[ "The", "evolutionarily", "conserved", "N-terminal", "half", "of", "IBR/F", "harbors", "the", "DNA-binding/dimerization", "domain", "(", "outer", "limits", ",", "127", "to", "283", ")", ",", "one", "or", "several", "casein", "kinase", "II", "sites", "(", "37", "to", "67", ")", ",", "and", "a", "bipartite", "nuclear", "localization", "signal", "(", "89", "to", "106", ")", "which", "appears", "to", "be", "necessary", "for", "nuclear", "targeting", "." ]
[ 0, 0, 0, 9, 10, 0, 9, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
11122
[ "This", "review", "outlines", "general", "features", "of", "signal", "transduction", "and", "several", "aspects", "of", "cytokine", "networks", "are", "discussed", "with", "emphasis", "on", ":", "transcriptional", "regulation", "of", "Th1", "and", "Th2-specific", "cytokine", "genes", "in", "T", "cells", ",", "the", "roles", "of", "cytokines", "and", "their", "receptors", "in", "growth", "and", "differentiation", "of", "hemopoietic", "cells", ",", "and", "the", "manipulation", "of", "cytokine", "networks", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 7, 8, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0, 0, 0, 0, 0, 9, 10, 0 ]
2772
[ "In", "some", "donors", ",", "increased", "IL-6", "and", "TNF-alpha", "activity", "also", "was", "detected", "after", "R24", "treatment", "." ]
[ 0, 0, 0, 0, 0, 9, 0, 9, 0, 0, 0, 0, 0, 9, 0, 0 ]
13605
[ "Since", "the", "inhibition", "of", "Ca2+", "redistribution", "by", "an", "inhibitor", "of", "intracellular", "Ca2+", "mobilization", ",", "8-", "(", "diethylamino", ")", "-octyl-3", ",", "4", ",", "5-trimethoxybenzoate", "hydrochloride", ",", "inhibited", "TCR-induced", "FasL", "but", "not", "Fas", ",", "the", "expression", "of", "Fas", "appears", "to", "be", "independent", "of", "Ca2+", "mobilization", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 9, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0 ]
12166
[ "Triptolide", "induces", "apoptotic", "death", "of", "T", "lymphocyte", "." ]
[ 0, 0, 0, 0, 0, 7, 8, 0 ]
17352
[ "The", "ability", "of", "both", "mitogens", "and", "cytokines", "to", "activate", "NF-kappa", "B", "was", "also", "blocked", "in", "Jurkat", "cells", "constitutively", "expressing", "Tax", "." ]
[ 0, 0, 0, 0, 0, 0, 9, 0, 0, 9, 10, 0, 0, 0, 0, 5, 6, 0, 0, 9, 0 ]
7213
[ "Moreover", ",", "following", "IL-2", "stimulation", "of", "T", "cells", ",", "SOCS-3", "was", "able", "to", "interact", "with", "the", "IL-2", "receptor", "complex", ",", "and", "in", "particular", "tyrosine", "phosphorylated", "Jak1", "and", "IL-2Rbeta", "." ]
[ 0, 0, 0, 9, 0, 0, 7, 8, 0, 9, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 0, 0, 0, 9, 10, 10, 0, 9, 0 ]
11787
[ "Using", "a", "panel", "of", "specific", "antisera", "in", "immunoprecipitation", "assays", ",", "we", "found", "that", "NFATp", "(", "135", "kDa", ")", "is", "constitutively", "expressed", "in", "normal", "human", "T", "cells", ",", "while", "synthesis", "of", "NFATc", "(", "predominant", "form", "of", "86", "kDa", ")", "is", "induced", "by", "ionomycin", "treatment", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 9, 10, 0, 0, 0, 0, 0, 7, 8, 8, 8, 0, 0, 0, 0, 9, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0 ]
5788
[ "Redox", "regulation", "of", "NF-kappa", "B", "has", "been", "implicated", "in", "the", "activation", "of", "the", "human", "immuno-deficiency", "virus", "(", "HIV", ")", "." ]
[ 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
452
[ "We", "have", "begun", "to", "examine", "the", "structure", "of", "the", "B2", "subunit", "promoter", "region", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 2, 0 ]
6441
[ "Intracellular", "deletion", "variants", "of", "TLR2", "lacking", "C-terminal", "13", "or", "141", "aa", "fail", "to", "recruit", "IRAK", ",", "which", "is", "consistent", "with", "the", "inability", "of", "these", "mutants", "to", "transmit", "LPS", "cellular", "signaling", "." ]
[ 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
17133
[ "All", "three", "proteins", "show", "the", "same", "sequence", "specificity", "and", "binding", "affinity", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
11197
[ "Hypermethylation", "within", "the", "promoters", "of", "some", "genes", "appear", "to", "be", "an", "early", "event", "in", "the", "pathogenesis", "of", "neoplasia", "(", "ER", ",", "P15", ")", ",", "while", "other", "genes", "seem", "to", "become", "methylated", "during", "the", "progression", "of", "leukemias", "(", "HIC1", ",", "c-abl", ")", "." ]
[ 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
2548
[ "The", "results", "are", "the", "first", "to", "characterize", "the", "novel", "membrane", "receptor", "for", "aldosterone", "with", "regard", "to", "molecular", "weight", "and", "basic", "properties", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
11533
[ "We", "examined", "the", "relationship", "between", "GC-receptor", "(", "GC-R", ")", "parameters", "in", "peripheral-blood", "mononuclear", "cells", "(", "PBMC", ")", "and", "PBMC", "resistance", "to", "GC", "in", "21", "CRF", "patients", "and", "18", "healthy", "subjects", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 8, 0, 7, 0, 0, 7, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
12977
[ "Using", "tetanus", "toxoid", "specific", "and", "HLA-DR-restricted", "T", "lymphocytes", ",", "we", "show", "that", "polarized", "intestinal", "epithelial", "cells", "directed", "to", "express", "HLA-DR", "molecules", "are", "able", "to", "initiate", "class", "II", "processing", "only", "after", "internalization", "of", "antigen", "from", "their", "apical", "surface", "." ]
[ 0, 7, 8, 8, 8, 8, 8, 8, 0, 0, 0, 0, 7, 8, 8, 8, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
8117
[ "Low", "levels", "of", "nuclear", "I", "(", "kappa", ")", "B", "(", "alpha", ")", "were", "detected", "in", "resting", "cells", "whereas", "a", "superinduction", "was", "obtained", "after", "PMA", "activation", "." ]
[ 0, 0, 0, 0, 9, 10, 10, 10, 10, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
11750
[ "Upon", "stimulation", "by", "various", "agents", ",", "I", "kappaB", "is", "proteolyzed", "and", "NF-kappaB", "translocates", "to", "the", "nucleus", ",", "where", "it", "activates", "its", "target", "genes", "." ]
[ 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
16996
[ "This", "gene", "is", "yet", "another", "in", "a", "growing", "list", "of", "important", "regulatory", "molecules", "whose", "expression", "is", "transcriptionally", "induced", "upon", "cellular", "activation", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
11556
[ "Expression", "of", "the", "HIV-1", "transactivator", "Tat", "recapitulated", "this", "phenotype", "and", "was", "associated", "with", "increased", "IL-2", "secretion", "in", "response", "to", "costimulation", "with", "CD3", "plus", "CD28", "." ]
[ 0, 0, 0, 9, 10, 9, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 9, 0, 9, 0 ]
672
[ "Interleukin", "4", "activates", "a", "signal", "transducer", "and", "activator", "of", "transcription", "(", "Stat", ")", "protein", "which", "interacts", "with", "an", "interferon-gamma", "activation", "site-like", "sequence", "upstream", "of", "the", "I", "epsilon", "exon", "in", "a", "human", "B", "cell", "line", "." ]
[ 9, 10, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 10, 0, 0, 0, 0, 1, 2, 2, 2, 0, 0, 0, 1, 2, 2, 0, 0, 5, 6, 6, 6, 0 ]
17232
[ "PMA", "enhanced", "slightly", "the", "stimulatory", "effect", "of", "PHA", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 9, 0 ]
14354
[ "In", "cotransfection", "experiments", ",", "oncogenic", "rats", "obviated", "the", "need", "for", "PKC", "stimulation", "but", "did", "not", "replace", "either", "the", "calcium", "signal", "or", "interleukin-1", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0 ]
17841
[ "These", "syncytia", "lack", "activated", "cells", "as", "determined", "by", "an", "absence", "of", "staining", "for", "Ki-67", "cell", "cycle", "antigen", "." ]
[ 0, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]