Datasets:

---

siddharthtumre

/

jnlpba-split

like 0

[ "An", "81", "%", "increment", "in", "promoter", "activity", "was", "obtained", "when", "a", "mutation", "was", "introduced", "in", "the", "GATA-3", "binding", "site", "of", "the", "bp", "-267", "to", "+12", "construct", ",", "which", "is", "comparable", "to", "that", "of", "the", "bp", "-245", "to", "+12", "construct", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 0, 0, 1, 2, 2, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 2, 2, 0 ]

[ "Over-expression", "of", "both", "genes", "was", "restricted", "to", "monocytes", "from", "II-2", "and", "was", "not", "observed", "in", "monocytes", "from", "the", "clinically", "unaffected", "family", "members", ",", "unlike", "that", "of", "SR", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 7, 0, 5, 0, 0, 0, 0, 0, 7, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0 ]

[ "These", "data", "are", "well", "in", "line", "with", "the", "long-standing", "notion", "that", "interindividual", "differences", "in", "platelet", "monoamine", "oxidase", "may", "represent", "differences", "in", "expression", "of", "the", "enzyme", "rather", "than", "genotypic", "variation", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Gel", "retardation", "assays", "with", "STAT-binding", "oligonucleotides", "showed", "that", "IL-7", "induces", "the", "formation", "of", "two", "major", "STAT", "complexes", "in", "BCP-ALL", "cells", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 9, 10, 0, 5, 6, 0 ]

[ "Here", "we", "show", "that", "Delta", "still", "utilizes", "the", "same", "pathways", "as", "wild-type", "ZAP-70", "to", "mediate", "NF-AT", "induction", "." ]

[ 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 9, 0, 0 ]

[ "In", "this", "study", ",", "we", "show", "that", "HLA", "class", "I", "-mediated", "induction", "of", "cell", "proliferation", "correlates", "with", "inactivation", "of", "the", "Rb", "protein", "in", "the", "T", "cell", "line", "Jurkat", "as", "well", "as", "human", "aortic", "endothelial", "cells", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 5, 6, 6, 6, 0, 0, 0, 7, 8, 8, 8, 0 ]

[ "Finally", ",", "the", "HTLV-I", "(", "+", ")", "T-cell", "lines", "(", "313", ")", "but", "not", "the", "control", ",", "HTLV-I", "(", "-", ")", "T-cell", "lines", "were", "resistant", "to", "rapamycin", "and", "its", "novel", "analog", "RAD", "." ]

[ 0, 0, 0, 5, 6, 6, 6, 6, 6, 0, 0, 0, 0, 0, 0, 0, 0, 5, 6, 6, 6, 6, 6, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "A", "second", "E2F-I", "binding", "protein", ",", "most", "likely", "DP-I", ",", "was", "also", "apparently", "normal", "in", "both", "class", "II-positive", "and", "-negative", "B-cell", "lines", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Incidentally", ",", "Grf40", "binds", "to", "linker", "for", "activation", "of", "T", "cells", "(", "LAT", ")", "possibly", "via", "its", "SH2", "domain", "." ]

[ 0, 0, 9, 0, 0, 9, 10, 10, 10, 10, 10, 0, 9, 0, 0, 0, 0, 9, 10, 0 ]

[ "A", "role", "for", "RanBP1", "in", "the", "release", "of", "CRM1", "from", "the", "nuclear", "pore", "complex", "in", "a", "terminal", "step", "of", "nuclear", "export", "." ]

[ 0, 0, 0, 9, 0, 0, 0, 0, 9, 0, 0, 9, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Cyclosporin", "A", "impaired", "not", "only", "early", "and", "late", ",", "but", "also", "immediate", "events", ";", "however", ",", "addition", "of", "TNF-alpha", "prevented", "all", "inhibition", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0 ]

[ "Cells", "pretreated", "with", "dimaprit", "showed", "a", "decrease", "in", "the", "cAMP", "response", "to", "subsequent", "addition", "of", "H2", "agonists", ",", "whereas", "the", "cAMP", "response", "to", "prostaglandin", "E2", "remained", "unaltered", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Addition", "of", "KCl", "resulted", "in", "less", "DNA", "binding", "either", "due", "to", "blockage", "of", "DNA-", "receptor", "complex", "formation", "or", "disruption", "of", "the", "complexes", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0 ]

[ "Tumor", "suppressor", "proteins", "as", "regulators", "of", "cell", "differentiation", "." ]

[ 9, 10, 10, 0, 0, 0, 0, 0, 0 ]

[ "Interaction", "of", "sickle", "erythrocytes", "with", "endothelial", "cells", "in", "the", "presence", "of", "endothelial", "cell", "conditioned", "medium", "induces", "oxidant", "stress", "leading", "to", "transendothelial", "migration", "of", "monocytes", "." ]

[ 0, 0, 7, 8, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 0 ]

[ "The", "drug", "exhibited", "distinct", "normalizing", "effect", "on", "patterns", "of", "calcium", "metabolism", ":", "increase", "of", "total", "and", "ionized", "Ca2+", "and", "of", "25-OHD", ",", "decrease", "in", "concentration", "of", "parath", "hormone", "and", "osteocalcine", "in", "blood", "serum", "as", "well", "as", "on", "immunological", "parameters", ":", "restoration", "of", "decreased", "content", "of", "T-", "and", "0-lymphocytes", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 8, 0 ]

[ "One", "of", "the", "proteins", "that", "binds", "to", "these", "sites", "is", "TRAF2", ",", "a", "signal", "transduction", "molecule", "that", "is", "also", "utilized", "by", "TNFR1", "to", "mediate", "the", "activation", "of", "several", "downstream", "kinases", "and", "transcription", "factors", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 9, 10, 10, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 9, 0, 9, 10, 0 ]

[ "In", "this", "study", ",", "we", "demonstrate", "the", "effects", "of", "DZA", "on", "nuclear", "factor-kappaB", "(", "NF-kappaB", ")", "regulation", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 9, 0, 0, 0 ]

[ "Thyroid", "hormones", "act", "by", "binding", "to", "nuclear", "receptor", "proteins", ",", "the", "thyroid", "hormone", "receptors", "(", "TR", ")", "alpha", "and", "beta", "." ]

[ 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 0, 9, 10, 10, 10, 10, 10, 10, 10, 10, 0 ]

[ "Indeed", ",", "IL-10", ",", "like", "IFN-gamma", ",", "was", "able", "to", "significantly", "reduce", "the", "amount", "of", "B-CLL", "cell", "death", "caused", "by", "hydrocortisone-induced", "apoptosis", "." ]

[ 0, 0, 9, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Correlation", "with", "an", "increased", "kappa", "B", "binding", "activity", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Thus", ",", "both", "copies", "of", "BRCA1", "were", "retained", "in", "tumor", "." ]

[ 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0 ]

[ "These", "observations", "suggest", "that", "resynthesis", "of", "I", "kappa", "B", "alpha", "and", "removal", "of", "the", "stimulus", "are", "obligatory", "steps", "for", "the", "inactivation", "of", "nuclear", "NF", "kappa", "B", "." ]

[ 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 0 ]

[ "We", "have", "used", "Western", "blotting", "to", "investigate", "the", "presence", "of", "these", "proteins", "during", "the", "cell", "cycles", "of", "two", "different", "cellular", "systems", ":", "a", "continuously", "growing", "myeloid", "leukemic", "cell", "line", ",", "HL60", ",", "and", "normal", "cells", "stimulated", "into", "cycle", ",", "phyto-", "hemagglutinin", "(", "PHA", ")", "-stimulated", "normal", "human", "peripheral", "blood", "lymphocytes", "(", "PBL", ")", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 6, 0, 0, 5, 6, 6, 6, 6, 6, 0, 5, 0, 0, 7, 8, 0, 0, 0, 0, 5, 6, 6, 6, 6, 6, 6, 6, 6, 6, 6, 0, 7, 0, 0 ]

[ "In", "contrast", ",", "neither", "the", "RA-stimulated", ",", "RARE", "-mediated", "transcription", "nor", "the", "induced", "RAR-beta", "expression", "was", "suppressed", "by", "VitD3", ",", "suggesting", "that", "VitD3", "selectively", "inhibited", "the", "retinoid-induced", "differentiation", "program", "but", "not", "the", "RARE", "-mediated", "signal", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0 ]

[ "Immunohistochemically", ",", "the", "immunoreaction", "against", "5", "steroid", "hormone", "anti-sera", "(", "estradiol", ",", "estriol", ",", "cortisol", ",", "progesterone", "and", "testosterone", ")", "was", "examined", "in", "39", "cases", "with", "the", "malignant", "soft", "tissue", "tumors", "(", "fibrosarcoma", ":", "8", ",", "malignant", "fibrous", "histiocytoma", ":", "6", ",", "rhabdomyosarcoma", ":", "10", ",", "leiomyosarcoma", ":", "10", ",", "liposarcoma", ":", "5", ")", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 8, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Enhanced", "activity", "of", "topoisomerases", "in", "nuclear", "extracts", "upon", "translocation", "of", "VDR", "might", "reflect", "interaction", "of", "both", "within", "the", "nuclear", "compartment", ",", "thus", "initiating", "DNA-unwinding", ",", "a", "prerequisite", "of", "transcription", "initiation", "." ]

[ 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "M.", "tuberculosis", "ManLAM", "resulted", "in", "clear", "induction", "of", "the", "luciferase", "gene", "placed", "under", "the", "control", "of", "the", "wild-type", ",", "but", "not", "the", "kappaB-mutated", ",", "HIV-1", "LTR", "region", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 1, 2, 2, 2, 2, 2, 2, 2, 2, 2, 0 ]

[ "We", "interpret", "this", "as", "a", "reflection", "of", "a", "low", "threshold", "for", "activation", "of", "the", "T", "cell", "clone", ",", "in", "which", "peptide-", "MHC", "avidity", "is", "the", "over-riding", "determinant", "of", "the", "strength", "of", "ligand", "signal", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 6, 6, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Glucocorticoid-mediated", "inhibition", "of", "interleukin-2", "receptor", "alpha", "and", "-beta", "subunit", "expression", "by", "human", "T", "cells", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "In", "contrast", ",", "CD19", "cross-linking", "in", "BLIN-1", "cells", "resulted", "in", "the", "induction", "of", "NF-kappaB", ",", "but", "had", "no", "apparent", "effect", "on", "AP-1", "-binding", "activity", "." ]

[ 0, 0, 0, 9, 0, 0, 5, 6, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0 ]

[ "Enhanced", "NF-kappa", "B", "binding", "activity", "is", "followed", "by", "functional", "activation", "in", "that", "inducibility", "of", "the", "IL-2", "receptor", "alpha", "chain", "is", "mediated", "by", "enhanced", "NF-kappa", "B", "binding", "and", "that", "a", "heterologous", "promoter", "containing", "the", "NF-kappa", "B", "consensus", "sequence", "(", "-291", "to", "-245", ")", "of", "the", "IL-2", "receptor", "alpha", "chain", "gene", "is", "activated", "." ]

[ 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 2, 0, 1, 2, 2, 0, 0, 0, 1, 2, 2, 2, 2, 0, 0, 0 ]

[ "However", ",", "the", "percentage", "of", "asymmetric", "molecules", "produced", "by", "the", "hybridoma", "remained", "unaltered", "." ]

[ 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 5, 0, 0, 0 ]

[ "This", "growth", "modulator", "was", "semipurified", "and", "had", "an", "estimated", "molecular", "weight", "13", ",", "000", "to", "24", ",", "000", "Da", "." ]

[ 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "In", "this", "study", ",", "we", "investigated", "the", "effects", "of", "IL-10", "on", "the", "activation", "of", "HIV-1", "from", "infected", "monocytes", "and", "macrophages", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 7, 8, 0, 7, 0 ]

[ "In", "an", "extended", "family", "we", "were", "able", "to", "study", "an", "aunt", "and", "her", "newborn", "daughter", ",", "who", "were", "both", "also", "biochemically", "affected", "but", "clinically", "asymptomatic", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "C-myb", "and", "B-myb", "were", "expressed", "in", "all", "neoplastic", "groups", ",", "except", "in", "CLL", "cells", "." ]

[ 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 6, 0 ]

[ "In", "epithelial", "cells", ",", "the", "Z", "transactivator", "alone", "produced", "maximal", "stimulation", "of", "the", "EA-D", "promoter", ";", "the", "effect", "of", "R", "and", "Z", "together", "was", "no", "greater", "than", "that", "of", "Z", "alone", "." ]

[ 0, 7, 8, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 9, 0, 9, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0 ]

[ "This", "study", "demonstrates", "that", "a", "T", "cell-mediated", "immune", "response", "as", "well", "as", "an", "endotoxic", "challenge", "during", "pregnancy", "can", "induce", "anomalies", "in", "HPA", "axis", "function", "in", "adulthood", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Authentic", "NFAT", "and", "NF-kappaB", "targets", "did", "not", "compete", "for", "the", "META", "(", "D+", ")", "binding", "factor", "(", "s", ")", "." ]

[ 0, 1, 2, 2, 2, 0, 0, 0, 0, 0, 9, 10, 10, 10, 10, 10, 0, 0, 0, 0 ]

[ "HLA-DMA", "and", "HLA-DMB", "gene", "expression", "functions", "through", "the", "conserved", "S-X-Y", "region", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0 ]

[ "Evaluation", "of", "the", "respiratory", "epithelium", "of", "normals", "and", "individuals", "with", "cystic", "fibrosis", "for", "the", "presence", "of", "adenovirus", "E1a", "sequences", "relevant", "to", "the", "use", "of", "E1a-", "adenovirus", "vectors", "for", "gene", "therapy", "for", "the", "respiratory", "manifestations", "of", "cystic", "fibrosis", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Northern", "blot", "analysis", "revealed", "that", "BLR2", "mRNA", "could", "be", "highly", "stimulated", "in", "mitogen-", "and", "anti-CD3-treated", "peripheral", "blood", "lymphocytes", "." ]

[ 0, 0, 0, 0, 0, 3, 4, 0, 0, 0, 0, 0, 5, 6, 6, 6, 6, 6, 0 ]

[ "Surprisingly", ",", "the", "PMA-ionomycin-induced", "synthesis", "of", "NFATc", "that", "was", "detected", "by", "immunoprecipitation", "was", "not", "mirrored", "in", "the", "DNA", "binding", "assays", ":", "nearly", "all", "of", "the", "activity", "was", "due", "to", "NFATp", "." ]

[ 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0 ]

[ "Freshly", "isolated", "monocytes", "constitutively", "expressed", "high", "levels", "of", "transcriptionally", "inactive", "p50", "homodimer", "which", "decreased", "with", "time", "in", "culture", "in", "favor", "of", "the", "transcriptionally", "active", "p50/p65", "and", "p50/RelB", "heterodimers", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 0 ]

[ "Nuclear", "factors", "from", "unstimulated", ",", "but", "not", "from", "activated", "cells", ",", "bound", "a", "site", ",", "META", "(", "D-", ")", ",", "adjacent", "to", "META", "(", "D+", ")", "." ]

[ 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 2, 0, 0, 0, 1, 2, 2, 2, 0 ]

[ "In", "contrast", ",", "gp41", "failed", "to", "stimulate", "NF-kappaB", "binding", "activity", "in", "as", "much", "as", "no", "NF-kappaB", "bound", "to", "the", "main", "NF-kappaB-binding", "site", "2", "of", "the", "IL-10", "promoter", "after", "addition", "of", "gp41", "." ]

[ 0, 0, 0, 9, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 1, 2, 2, 0, 0, 0, 1, 2, 0, 0, 0, 9, 0 ]

[ "Modulation", "of", "the", "immune", "response", "and", "tumor", "growth", "by", "activated", "Ras", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0 ]

[ "Tax", "-mediated", "transformation", "of", "T", "cells", "likely", "involves", "the", "deregulated", "expression", "of", "various", "cellular", "genes", "that", "normally", "regulate", "lymphocyte", "growth", "produced", "by", "altered", "activity", "of", "various", "endogenous", "host", "transcription", "factors", "." ]

[ 9, 0, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 7, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0 ]

[ "(", "2", ")", "Intrafollicular", "CD3+", "T", "cells", ",", "many", "of", "which", "were", "also", "positive", "for", "Bcl-6", ",", "were", "markedly", "depleted", "in", "AITL/GC", ",", "with", "increased", "interfollicular", "Bcl-6+/CD3+", "cells", ",", "suggesting", "an", "outward", "migration", "of", "intrafollicular", "T", "cells", "in", "this", "condition", "." ]

[ 0, 0, 0, 7, 8, 8, 8, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 7, 8, 8, 0, 0, 0, 0 ]

[ "Pharmacologic", "control", "of", "trans-gene", "expression", "in", "gene-modified", "T", "cells", "will", "not", "only", "facilitate", "new", "approaches", "to", "the", "study", "of", "different", "aspects", "of", "T", "cell", "biology", ",", "but", "will", "also", "provide", "the", "basis", "for", "new", "gene", "therapy", "strategies", "." ]

[ 0, 0, 0, 0, 0, 0, 5, 6, 6, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Tissue", "factor", "expression", "of", "human", "monocytes", "is", "suppressed", "by", "lysophosphatidylcholine", "." ]

[ 0, 0, 0, 0, 7, 8, 0, 0, 0, 0, 0 ]

[ "The", "generation", "of", "genomic", "diversity", "during", "the", "course", "of", "infection", "has", "the", "potential", "to", "affect", "all", "aspects", "of", "HIV-1", "replication", ",", "including", "expression", "of", "the", "proviral", "genome", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0 ]

[ "Transcription", "factor", "IID", "(", "TFIID", ")", "binds", "to", "the", "TATA", "box", "promoter", "element", "and", "regulates", "the", "expression", "of", "most", "eukaryotic", "genes", "transcribed", "by", "RNA", "polymerase", "II", "." ]

[ 9, 10, 10, 0, 9, 0, 0, 0, 0, 1, 2, 2, 2, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 9, 10, 10, 0 ]

[ "We", "have", "pursued", "our", "investigation", "of", "the", "role", "of", "the", "CD4", "transduction", "pathway", "in", "HIV-induced", "apoptosis", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0 ]

[ "The", "AP-1", "mutant", "constructs", "also", "showed", "delayed", "transcriptional", "activation", "in", "PMA-treated", "fibroblasts", "." ]

[ 0, 1, 2, 2, 0, 0, 0, 0, 0, 0, 5, 6, 0 ]

[ "These", "mutations", "paralleled", "those", "in", "other", "viral", "strains", "passaged", "in", "vitro", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Immuno-histochemical", "analysis", "confirmed", "the", "presence", "of", "NGAL", "within", "breast", "carcinoma", "cells", "but", "detected", "only", "low", "levels", "of", "this", "protein", "in", "normal", "ductal", "epithelium", "." ]

[ 0, 0, 0, 0, 0, 0, 9, 0, 7, 8, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "The", "latter", "class", "of", "events", "is", "blocked", "in", "lymphocytes", "by", "the", "immunosuppressive", "drugs", "cyclosporin", "A", "and", "FK506", ",", "which", "inhibit", "calcineurin", ",", "a", "Ca2+-activated", "serine/threonine", "phosphatase", "necessary", "for", "the", "nuclear", "import", "of", "NF-AT", "transcription", "factors", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 7, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 9, 10, 10, 0, 0, 0, 0, 0, 0, 9, 9, 10, 0 ]

[ "This", "sequence", "is", "well", "conserved", "in", "various", "HIV-1", "isolates", "and", "partial", "homology", "was", "found", "with", "the", "promoter", "region", "of", "the", "human", "retinoblastoma", "gene", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 1, 2, 2, 0 ]

[ "Estrogen", "may", "modify", "the", "activity", "of", "neutrophils", "during", "the", "normal", "menstrual", "cycle", ",", "not", "only", "during", "pregnancy", ",", "and", "influence", "inflammation", "." ]

[ 0, 0, 0, 0, 0, 0, 7, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Immunoblotting", "experiments", "with", "U937", "cells", "demonstrate", "that", "PKC-zeta", "is", "present", "in", "these", "cells", ",", "and", "its", "expression", "can", "be", "downmodulated", "by", "antisense", "oligonucleotides", "(", "AO", ")", "." ]

[ 0, 0, 0, 5, 6, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "DNA-swap", "experiments", "using", "chloramphenicol", "acetyl-transferase", "assay", "demonstrated", "that", "androgen", "can", "suppress", "the", "transcriptional", "activities", "of", "SV40", "early", "promoter", "via", "the", "interaction", "between", "this", "TR2RE-SV40", "and", "the", "chimeric", "receptor", "AR/TR2/AR", "with", "the", "DNA-binding", "domain", "of", "the", "TR2", "orphan", "receptor", "flanked", "by", "the", "N-terminal", "and", "androgen-binding", "domains", "of", "the", "androgen", "receptor", "." ]

[ 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 0, 0, 0, 0, 0, 1, 0, 0, 9, 10, 10, 0, 0, 9, 10, 0, 0, 9, 10, 10, 0, 0, 0, 9, 10, 10, 10, 0, 0, 9, 10, 0 ]

[ "Signalling", "into", "the", "T-cell", "nucleus", ":", "NFAT", "regulation", "." ]

[ 0, 0, 0, 0, 0, 0, 9, 0, 0 ]

[ "RelB", "protein", "and", "mRNA", "were", "detected", "constitutively", "in", "lymphocytes", "and", "in", "activated", "monocytes", ",", "differentiated", "DC", ",", "and", "monocyte-derived", "DC", "." ]

[ 9, 0, 0, 3, 0, 0, 0, 0, 7, 0, 0, 7, 8, 0, 7, 8, 0, 0, 5, 6, 0 ]

[ "Thus", ",", "Smad6", "and", "Smad7", "exhibit", "differential", "inhibitory", "effects", "in", "bone", "morphogenetic", "protein-2-", "and", "activin", "A-mediated", "signaling", "in", "B", "lineage", "cells", "." ]

[ 0, 0, 9, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 8, 0 ]

[ "These", "results", "indicate", "that", "in", "monocytic", "cell", "lineage", ",", "HIV-1", "could", "mimic", "some", "differentiation/activation", "stimuli", "allowing", "nuclear", "NF-KB", "expression", "." ]

[ 0, 0, 0, 0, 0, 5, 6, 6, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0 ]

[ "The", "ability", "of", "BHRF1", "to", "inhibit", "apoptosis", "is", "dependent", "on", "stimulus", "and", "cell", "type", "." ]

[ 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Direct", "activation", "of", "PKC", "with", "PMA", "induced", "both", "NF-kappaB", "activation", "and", "TNF-alpha", "production", "by", "human", "monocytes", "." ]

[ 0, 0, 0, 9, 0, 0, 0, 0, 9, 0, 0, 9, 0, 0, 7, 8, 0 ]

[ "DMDTC", "does", "not", "appear", "to", "alter", "NF-kappaB", "directly", "as", "pre-incubation", "of", "nuclear", "extracts", "with", "DMDTC", "does", "not", "diminish", "binding", "activity", "of", "this", "protein", "." ]

[ 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "We", "molecularly", "cloned", "a", "new", "Grb2", "family", "member", ",", "named", "Grf40", ",", "containing", "the", "common", "SH3-SH2-SH3", "motif", "." ]

[ 0, 0, 0, 0, 0, 9, 10, 10, 0, 0, 9, 0, 0, 0, 0, 9, 10, 0 ]

[ "Immature", "thymocytes", "were", "infected", "by", "EBV", ",", "as", "determined", "by", "the", "internalization", "of", "the", "viral", "genome", "and", "its", "transcriptional", "activity", "." ]

[ 0, 7, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0 ]

[ "Thus", ",", "the", "regulation", "of", "the", "gene", "coding", "for", "the", "main", "T", "cell", "growth", "factor", "changes", "irreversibly", "after", "the", "first", "encounter", "of", "T", "cells", "with", "antigen", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Furthermore", ",", "GcR", "were", "unaltered", "after", "these", "patients", "received", "ketoconazole", ",", "in", "spite", "of", "a", "marked", "reduction", "in", "morning", "plasma", "cortisol", "and", "urinary", "free", "cortisol", "." ]

[ 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Pretreatment", "of", "cells", "with", "protein", "tyrosine", "kinase", "inhibitors", "and", "the", "dominant", "negative", "allele", "of", "c-Raf-1", "(", "Raf", "301", ")", "inhibited", "I", "kappa", "B", "alpha", "degradation", ",", "NF-kappa", "B", "binding", ",", "and", "transactivation", "of", "kappa", "B", "reporter", "constructs", "by", "hypoxia", "." ]

[ 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 1, 2, 2, 0, 1, 0, 9, 10, 0, 0, 9, 10, 10, 10, 0, 0, 9, 10, 0, 0, 0, 0, 0, 1, 2, 2, 2, 0, 0, 0 ]

[ "In", "this", "report", ",", "we", "describe", "the", "transcriptional", "regulation", "of", "the", "beta-casein", "gene", "by", "cytokines", "in", "T", "cells", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 9, 0, 7, 8, 0 ]

[ "The", "gene", "expression", "of", "interferon", "(", "IFN", ")", "-inducible", "protein", "10", "(", "IP-10", ")", "(", "a", "CXC", "chemokine", ")", "was", "markedly", "augmented", "by", "the", "IFNgamma", "treatment", "in", "PMA", "-or", "RA-differentiated", "U937", "cells", ",", "but", "only", "marginally", "in", "undifferentiated", "or", "VitD3-treated", "cells", "." ]

[ 0, 0, 0, 0, 9, 10, 10, 10, 10, 10, 10, 0, 9, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 5, 6, 0, 0, 0, 0, 0, 0, 0, 5, 6, 0 ]

[ "The", "specificity", "of", "HePTP", "correlated", "with", "its", "physical", "association", "through", "its", "noncatalytic", "N", "terminus", "with", "Erk", "and", "another", "MAP", "kinase", ",", "p38", ",", "but", "not", "Jnk", "or", "other", "proteins", "." ]

[ 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 9, 0, 0, 9, 10, 0, 9, 0, 0, 0, 9, 0, 0, 0, 0 ]

[ "Upon", "cellular", "activation", ",", "expression", "of", "the", "L-selectin", "gene", "is", "downregulated", "at", "both", "the", "protein", "and", "mRNA", "levels", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Human", "T", "cell", "lymphotropic", "virus", "type", "I", "(", "HTLV-I", ")", "encodes", "the", "transactivator", "protein", ",", "Tax", ",", "which", "facilitates", "viral", "transcription", "from", "three", "21", "bp", "repeated", "elements", "within", "the", "U3", "region", "of", "the", "long", "terminal", "repeat", "(", "LTR", ")", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 9, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 2, 0, 0, 1, 2, 0, 0, 1, 2, 2, 0, 1, 0, 0 ]

[ "Activation", "of", "human", "macrophages", "by", "mechanical", "ventilation", "in", "vitro", "." ]

[ 0, 0, 7, 8, 0, 0, 0, 0, 0, 0 ]

[ "These", "effects", "were", "blocked", "by", "mAbs", "against", "endothelial", "and/or", "leukocyte", "adhesion", "molecules", "(", "beta1", "and", "beta2", "integrins", ")", "." ]

[ 0, 0, 0, 0, 0, 9, 0, 9, 10, 10, 10, 10, 0, 9, 10, 10, 10, 0, 0 ]

[ "The", "long-term", "exposure", "of", "Jurkat", "cells", "to", "hormone", "eventually", "results", "in", "a", "selection", "of", "cell", "clones", "that", "have", "lost", "Tax", "activity", "." ]

[ 0, 0, 0, 0, 5, 6, 0, 0, 0, 0, 0, 0, 0, 0, 5, 6, 0, 0, 0, 9, 0, 0 ]

[ "PHA", "-induced", "proliferation", "of", "PBMCs", "dropped", "significantly", "in", "patients", "who", "received", "adjuvant", "chemotherapy", "consisting", "of", "cyclophosphamide", ",", "methotrexate", "and", "fluorouracil", "(", "CMF", ")", "after", "an", "observation", "period", "of", "6", "months", "(", "P", "<", "0.01", ")", ",", "but", "not", "in", "patients", "under", "adjuvant", "treatment", "with", "tamoxifen", "only", "." ]

[ 9, 0, 0, 0, 7, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Electrophoretic", "mobility", "shift", "assays", "demonstrated", "no", "difference", "in", "the", "pattern", "of", "TNF", "-stimulated", "nuclear", "factor-kappaB", "activation", "between", "HUVECs", "and", "HUAECs", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 9, 10, 0, 0, 7, 0, 7, 0 ]

[ "The", "transcription", "factors", "PU.1", "and", "C/EBPalpha", "are", "responsible", "for", "normal", "myeloid", "differentiation", "from", "stem", "cells", "to", "monocytes", "or", "granulocytes", "." ]

[ 0, 9, 10, 9, 0, 9, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0, 7, 0, 0, 0 ]

[ "Staphylococcal", "enterotoxins", "(", "SE", ")", "stimulate", "T", "cells", "expressing", "the", "appropriate", "variable", "region", "beta", "chain", "of", "(", "V", "beta", ")", "T-cell", "receptors", "and", "have", "been", "implicated", "in", "the", "pathogenesis", "of", "several", "autoimmune", "diseases", "." ]

[ 9, 10, 0, 9, 0, 0, 7, 8, 0, 0, 0, 9, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "The", "CD2", "T", "lymphocyte", "glycoprotein", "surface", "molecule", "mediates", "both", "cell", "to", "cell", "adhesion", "and", "T", "cell", "activation", ",", "two", "processes", "that", "are", "involved", "in", "the", "spread", "of", "HIV", "infection", "." ]

[ 0, 9, 10, 10, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "IL-10", "effected", "dose-dependent", "inhibition", "of", "tumor", "necrosis", "factor", "alpha", "(", "TNF-alpha", ")", "release", "in", "PBMC", "stimulated", "by", "LPS", "and", "C.", "neoformans", ",", "with", "significant", "inhibition", "seen", "with", "0.1", "U/ml", "and", "greater", "than", "90", "%", "inhibition", "noted", "with", "10", "U/ml", "." ]

[ 9, 0, 0, 0, 0, 9, 10, 10, 10, 0, 9, 0, 0, 0, 7, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "In", "this", "study", ",", "we", "observed", "that", "curcumin", "(", "50", "microM", ")", "inhibited", "proliferation", "of", "rat", "thymocytes", "stimulated", "with", "concanavalin", "A", "(", "Con", "A", ")", "as", "well", "as", "that", "of", "human", "Jurkat", "lymphoblastoid", "cells", "in", "the", "logarithmic", "growth", "phase", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 8, 8, 0, 0, 0, 0, 0, 0 ]

[ "We", "recently", "identified", "the", "winged-helix", "transcription", "factor", "Trident", "and", "described", "its", "expression", "pattern", "in", "synchronized", "fibroblasts", "." ]

[ 0, 0, 0, 0, 9, 10, 10, 9, 0, 0, 0, 0, 0, 0, 7, 8, 0 ]

[ "Numerous", "studies", "have", "shown", "that", ",", "upon", "HIV1", "infection", ",", "human", "promonocytic", "U937", "cells", "were", "induced", "to", "differentiate", ",", "as", "indicated", ",", "for", "example", ",", "by", "increased", "expression", "of", "adhesion", "molecules", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 6, 6, 6, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0 ]

[ "Decreased", "concentration", "of", "1", ",", "25-dihydroxyvitamin", "D3", "receptors", "in", "peripheral", "mononuclear", "cells", "of", "patients", "with", "X-linked", "hypophosphatemic", "rickets", ":", "effect", "of", "phosphate", "supplementation", "." ]

[ 0, 0, 0, 9, 10, 10, 10, 10, 0, 7, 8, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Apoptosis", "is", "implicated", "in", "the", "generation", "and", "resolution", "of", "inflammation", "in", "response", "to", "bacterial", "pathogens", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Propylthiouracil", "(", "50", "mumol/L", ")", "did", "not", "affect", "the", "action", "of", "T3SO4", ",", "suggesting", "that", "deiodination", "was", "not", "important", "for", "this", "activity", "of", "T3SO4", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Strains", "with", "mutations", "in", "either", "gene", "of", "the", "regulatory", "pair", "(", "phoP", "[", "transcriptional", "activator", "]", "or", "phoQ", "[", "membrane", "sensor", "kinase", "]", ")", "had", "increased", "sensitivities", "to", "defensin", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 1, 0, 1, 2, 0, 0, 1, 0, 9, 10, 10, 0, 0, 0, 0, 0, 0, 9, 0 ]

[ "The", "available", "data", "suggest", "that", "the", "NF", "kappa", "B2", "nucleoprotein", "complex", "may", "cooperate", "with", "DNA-bound", "STAT6", "to", "achieve", "IL-4", "-dependent", "activation", "of", "the", "human", "IgE", "germline", "gene", "." ]

[ 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 10, 0, 0, 0, 9, 10, 0, 0, 9, 0, 0, 0, 0, 1, 2, 2, 2, 0 ]

[ "Estrogens", "and", "anti-estrogens", "enhance", "the", "number", "of", "immunoglobulin", "(", "Ig", ")", "-secreting", "cells", "in", "pokeweed", "mitogen", "(", "PWM", ")", "-stimulated", "lymphocyte", "cultures", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 7, 8, 8, 8, 8, 8, 0, 5, 6, 6, 6, 6, 6, 6, 6, 0 ]

[ "The", "response", "element", "for", "NF-AT", "is", "a", "sequence", "localized", "between", "-285/-254", "in", "the", "IL-2", "regulatory", "region", "." ]

[ 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 1, 0, 0, 1, 2, 2, 0 ]

[ "Inactive", "calcineurin", "is", "unable", "to", "activate", "the", "nuclear", "factor", "of", "activated", "T", "cells", "(", "NFAT", ")", ",", "a", "transcription", "factor", "required", "for", "expression", "of", "the", "interleukin", "2", "(", "IL-2", ")", "gene", "." ]

[ 0, 9, 0, 0, 0, 0, 0, 9, 10, 10, 10, 10, 10, 0, 9, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 1, 2, 2, 2, 2, 2, 0 ]