Datasets:

---

siddharthtumre

/

jnlpba-split

like 0

[ "Locus", "control", "regions", "(", "LCRs", ")", "are", "powerful", "assemblies", "of", "cis", "elements", "that", "organize", "the", "actions", "of", "cell-type-specific", "trans-acting", "factors", "." ]

[ 1, 2, 2, 0, 1, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 9, 10, 10, 0 ]

[ "Activation", "of", "pp90rsk", "and", "early", "growth", "response-1", "gene", "expression", "by", "pokeweed", "mitogen", "in", "human", "B", "cells", "." ]

[ 0, 0, 9, 0, 1, 2, 2, 2, 0, 0, 9, 10, 0, 7, 8, 8, 0 ]

[ "To", "investigate", "whether", "the", "molar", "ratio", "of", "HSF2-alpha", "and", "HSF2-beta", "isoforms", "is", "crucial", "for", "the", "activation", "of", "HSF2", "and", "whether", "the", "HSF2", "isoforms", "play", "functionally", "distinct", "roles", "during", "the", "hemin-mediated", "erythroid", "differentiation", ",", "we", "generated", "cell", "clones", "expressing", "different", "levels", "of", "HSF2-alpha", "and", "HSF2-beta", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 9, 0, 9, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 9, 0 ]

[ "In", "addition", ",", "forced", "expression", "of", "GATA3", "potentiated", "the", "induction", "of", "RALDH2", "by", "TAL1", "and", "LMO", ",", "and", "these", "three", "factors", "formed", "a", "complex", "in", "vivo", "." ]

[ 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 9, 0, 9, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "We", "then", "investigated", "if", "HCMV", "binding", "also", "resulted", "in", "the", "translation", "and", "secretion", "of", "cytokines", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0 ]

[ "CD40", "induced", "not", "only", "nuclear", "translocation", "but", "also", "de", "novo", "synthesis", "of", "RelB", "RNA", "and", "protein", "." ]

[ 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 4, 0, 0, 0 ]

[ "Triggering", "of", "the", "human", "interleukin-6", "gene", "by", "interferon-gamma", "and", "tumor", "necrosis", "factor-alpha", "in", "monocytic", "cells", "involves", "cooperation", "between", "interferon", "regulatory", "factor-1", ",", "NF", "kappa", "B", ",", "and", "Sp1", "transcription", "factors", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 9, 10, 10, 0, 0, 9, 9, 10, 0 ]

[ "The", "activation", "of", "JNK", "by", "classical", "T", "cell", "stimuli", "was", "transient", ",", "whereas", "that", "mediated", "by", "PDTC", "and", "butylated", "hydroxyanisole", "(", "but", "not", "N-acetylcysteine", ")", "was", "sustained", "." ]

[ 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Our", "results", "suggest", "that", "the", "germline", "promoters", "and", "V", "region", "promoters", "differ", "in", "their", "dependence", "on", "octamer", "for", "activation", "and", "respond", "differently", "to", "enhancer", "activation", "." ]

[ 0, 0, 0, 0, 0, 1, 2, 0, 1, 2, 2, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Tyloxapol", "also", "reduces", "the", "viscosity", "of", "CF", "sputum", "(", "from", "463", "+/-", "133", "to", "128", "+/-", "52", "centipoise", ")", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Furthermore", ",", "PDTC", "differentially", "targeted", "both", "NFATp", "and", "NFATc", "family", "members", ",", "inhibiting", "the", "transactivation", "functions", "of", "NFATp", "and", "mRNA", "induction", "of", "NFATc", "." ]

[ 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 10, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 9, 0 ]

[ "Characterization", "of", "CD40", "signaling", "determinants", "regulating", "nuclear", "factor-kappa", "B", "activation", "in", "B", "lymphocytes", "." ]

[ 0, 0, 9, 0, 0, 0, 9, 10, 10, 0, 0, 7, 8, 0 ]

[ "Recent", "isolation", "of", "the", "CD11b", "promoter", "shows", "that", "92", "base", "pairs", "(", "bp", ")", "of", "5'-flanking", "DNA", "are", "sufficient", "to", "direct", "myeloid-specific", "expression", "of", "a", "reporter", "gene", "." ]

[ 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0 ]

[ "The", "human", "autosomal", "recessive", "disease", ",", "xeroderma", "pigmentosum", "(", "XP", ")", ",", "can", "result", "from", "mutations", "in", "any", "one", "of", "seven", "genes", ",", "designated", "XPA", "through", "XPG", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 1, 0 ]

[ "Adenovirus", "(", "Ad", ")", "infection", "and", "E1A", "transfection", "were", "used", "to", "model", "changes", "in", "susceptibility", "to", "NK", "cell", "killing", "caused", "by", "transient", "vs", "stable", "E1A", "expression", "in", "human", "cells", "." ]

[ 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 7, 8, 0 ]

[ "Thus", ",", "the", "translocation", "event", "per", "se", "occurs", "independently", "of", "PKC", "activation", "in", "these", "cells", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0 ]

[ "This", "effect", "was", "paralleled", "by", "a", "reduction", "in", "the", "expression", "of", "MSR", "protein", "and", "mRNA", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 3, 0 ]

[ "Transient", "transfection", "studies", "demonstrate", "further", "that", "TCR", "-stimulated", "activation", "of", "the", "Ras", "signaling", "pathway", "is", "required", "for", "optimal", "activation", "of", "CD95", "ligand", "." ]

[ 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0 ]

[ "In", "monocytes", ",", "the", "virus", "was", "bound", "to", "the", "surface", "without", "being", "internalized", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "BCL-6", "mRNA", "levels", "began", "to", "decrease", "8", "to", "16", "hours", "after", "stimulation", ",", "before", "cells", "entered", "S", "phase", "." ]

[ 3, 4, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Cotransfection", "of", "gamma", "B*CaM-K", "with", "the", "IL-2", "promoter", "construct", "downregulated", "its", "transcription", "in", "response", "to", "stimulation", "with", "ionomycin", "and", "phorbol", "myristate", "acetate", "(", "PMA", ")", "." ]

[ 0, 0, 9, 10, 0, 0, 1, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Spi-B", "is", "an", "Ets", "transcription", "factor", "related", "to", "the", "oncoprotein", "Spi-1/PU.1", "and", "highly", "expressed", "in", "B", "lymphoid", "cells", "." ]

[ 9, 0, 0, 9, 10, 10, 0, 0, 0, 9, 9, 0, 0, 0, 0, 7, 8, 8, 0 ]

[ "Nuclear", "transcription", "factor", "kB", "(", "NF-kappa", "B", ")", "is", "a", "ubiquitous", "transcription", "factor", "and", "pleiotropic", "regulator", "of", "numerous", "genes", "involved", "in", "the", "immune", "and", "inflammatory", "responses", "." ]

[ 9, 10, 10, 10, 0, 9, 10, 0, 0, 0, 9, 10, 10, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Removal", "of", "the", "upstream", "sequences", "located", "between", "positions", "-78", "and", "-38", "resulted", "in", "decreased", "promoter", "strength", "and", "abolished", "the", "response", "to", "phorbol", "12-myristate", "13-acetate", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "The", "retinoblastoma", "gene", "product", "(", "pRB", ")", "plays", "an", "important", "role", "in", "controlling", "both", "cell", "release", "from", "the", "G1", "phase", "and", "apoptosis", "." ]

[ 0, 9, 10, 10, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Analysis", "of", "the", "modulation", "of", "transcriptional", "activity", "in", "myelopoiesis", "and", "leukemogenesis", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Freshly", "isolated", "cells", "show", "high", "levels", "of", "FOSB/G0S3", "and", "FOS/G0S7", "mRNAs", ",", "which", "decline", "rapidly", "during", "incubation", "in", "culture", "medium", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 3, 4, 4, 4, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "The", "results", "obtained", "by", "transient", "transfection", "of", "fos", "-CAT", "constructs", "that", "contained", "serial", "5'-deletion", "mutations", "showed", "that", "the", "region", "between", "-3134", "and", "-3059", "appears", "to", "be", "required", "for", "the", "induction", "of", "transcription", "by", "LPS", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 1, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "BACKGROUND", ":", "Fibrin", "deposition", "and", "thrombosis", "have", "been", "implicated", "in", "both", "allograft", "rejection", "and", "vasculopathy", "after", "cardiac", "transplantation", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Propagation", "of", "signals", "from", "the", "T", "cell", "antigen", "receptor", "(", "TCR", ")", "involves", "a", "number", "of", "adaptor", "molecules", "." ]

[ 0, 0, 0, 0, 0, 9, 10, 10, 10, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Treatment", "of", "HL60", "cells", "with", "various", "combinations", "of", "retinoids", "and", "1", "alpha", ",", "25", "dihydroxyvitamin", "D3", "results", "in", "differentiation", "towards", "neutrophils", "or", "monocytes", "or", "a", "failure", "to", "differentiate", "and", "apoptosis", "." ]

[ 0, 0, 5, 6, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 0, 7, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Expression", "of", "the", "CD95", "(", "APO-1/Fas", ")", "ligand", "(", "CD95L", ")", "in", "activated", "T", "cells", "is", "a", "major", "cause", "of", "T", "cell", "activation-induced", "apoptosis", "." ]

[ 0, 0, 0, 9, 10, 10, 10, 10, 0, 9, 0, 0, 7, 8, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Induction", "of", "ICAM-1", "and", "LFA-3", "by", "Tax1", "of", "human", "T-cell", "leukemia", "virus", "type", "1", "and", "mechanism", "of", "down-regulation", "of", "ICAM-1", "or", "LFA-1", "in", "adult-T-cell-leukemia", "cell", "lines", "." ]

[ 0, 0, 9, 0, 9, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 9, 0, 5, 6, 6, 0 ]

[ "Here", "we", "report", "a", "real-time", "study", "of", "factor/DNA", "interactions", "using", "a", "surface", "plasmon", "resonance", "approach", "and", "further", "characterization", "of", "recovered", "proteins", "involved", "in", "this", "interaction", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0 ]

[ "An", "open", "reading", "frame", "of", "1206", "nucleotides", "is", "in", "frame", "with", "a", "diverged", "homeodomain", "." ]

[ 0, 1, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0 ]

[ "These", "findings", "strongly", "suggest", "that", "the", "mechanism", "for", "previously", "described", "upregulation", "of", "platelet", "thromboxane", "receptors", "after", "acute", "myocardial", "infarction", "is", "increased", "thromboxane", "receptor", "gene", "transcription", "in", "platelet-progenitor", "cells", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 0, 0, 0, 0, 0, 1, 2, 2, 0, 0, 7, 8, 0 ]

[ "Increased", "c-jun", ",", "jun-B", ",", "and", "jun-D", "expression", "above", "basal", "levels", "and", "increased", "transcriptional", "activity", "of", "AP-1/TPA", "responsive", "elements", "fused", "to", "chloramphenicol", "acetyl-transferase", "vectors", "were", "observed", "in", "T", "cells", "treated", "with", "TPA", "alone", "or", "in", "combination", "with", "dexamethasone", "." ]

[ 0, 9, 0, 9, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 0, 0, 1, 2, 2, 0, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Between", "12", "and", "14", "months", "of", "age", ",", "10", "%", "of", "them", "develop", "a", "form", "of", "acute", "leukemia", "with", "a", "differentiation", "block", "at", "the", "promyelocytic", "stage", "that", "closely", "mimics", "human", "APL", "even", "in", "its", "response", "to", "retinoic", "acid", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Interestingly", ",", "all", "those", "early", "and", "late", "events", ",", "but", "not", "the", "immediate", "ones", ",", "were", "inhibited", "by", "a", "neutralizing", "anti-tumor", "necrosis", "factor", "alpha", "(", "TNF-alpha", ")", "monoclonal", "antibody", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 10, 10, 10, 10, 10, 0 ]

[ "Heterodimerization", "and", "transcriptional", "activation", "in", "vitro", "by", "NF-kappa", "B", "proteins", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0 ]

[ "Risk", "factors", "for", "local", "failure", "were", "evaluated", "for", "496", "clinical", "Stage", "I-II", "patients", "with", "infiltrating", "ductal", "carcinomas", "(", "median", "follow-up", ",", "71", "months", ")", "treated", "by", "conservative", "surgery", "and", "radiotherapy", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Using", "a", "modified", "sperm", "typing", "protocol", ",", "the", "mutation", "frequency", "of", "the", "CAG", "repeat", "region", "at", "the", "androgen", "receptor", "locus", "has", "been", "measured", "using", "a", "rare", "semen", "sample", "from", "an", "individual", "with", "spinal", "and", "bulbar", "muscular", "atrophy", "(", "SBMA", ")", "." ]

[ 0, 0, 0, 7, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 0, 0, 1, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "We", "also", "studied", "blasts", "from", "18", "patients", "with", "acute", "myeloid", "leukaemia", "(", "AML", ")", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "It", "was", "inhibited", "at", "1", "hr", ",", "reached", "a", "nadir", "at", "2-4", "hr", ",", "started", "to", "increase", "at", "8", "hr", ",", "and", "returned", "to", "basal", "levels", "at", "24", "hr", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "PI3-kinase", "activity", "was", "an", "upstream", "activator", "of", "PKB/Akt", "because", "the", "PI3-kinase", "inhibitor", "LY294002", "blocked", "both", "constitutive", "PKB/Akt", "and", "factor-dependent", "PKB/Akt", "activity", "." ]

[ 9, 0, 0, 0, 0, 0, 0, 9, 0, 0, 9, 0, 0, 0, 0, 0, 9, 0, 0, 9, 0, 0 ]

[ "Indeed", ",", "transient", "transfection", "of", "HLA-DRA", "and", "DQB", "reporter", "constructs", "indicated", "that", "the", "affected", "factor", "operates", "via", "cis-elements", "located", "between", "-141", "base", "pairs", "and", "the", "transcription", "initiation", "site", "." ]

[ 0, 0, 0, 0, 0, 1, 2, 2, 2, 2, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 1, 2, 2, 0, 0, 1, 2, 2, 0 ]

[ "Tumor", "necrosis", "factor", "(", "TNF", ")", "mediates", "a", "wide", "variety", "of", "disease", "states", "including", "septic", "shock", ",", "acute", "and", "chronic", "inflammation", ",", "and", "cachexia", "." ]

[ 9, 10, 10, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Activation", "of", "the", "transcription", "factor", "nuclear", "factor-kappaB", "(", "NFkappaB", ")", "is", "impaired", "in", "T", "cells", "from", "patients", "with", "renal", "cell", "carcinomas", "(", "RCCs", ")", "." ]

[ 0, 0, 0, 9, 10, 10, 10, 0, 9, 0, 0, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "However", ",", "this", "mutated", "NF", "kappa", "B", "promoter", "was", "not", "transactivated", "during", "HHV-6", "(", "GS", ")", "infection", "or", "after", "cotransfection", "with", "pZVB70", "or", "pZVB10", "." ]

[ 0, 0, 0, 1, 2, 2, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 1, 0 ]

[ "Furthermore", ",", "p50", "protein", "was", "detected", "in", "the", "cytoplasm", "of", "all", "lymphocytes", "." ]

[ 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 7, 0 ]

[ "Expression", "of", "Ah", "receptor", "(", "TCDD", "receptor", ")", "during", "human", "monocytic", "differentiation", "." ]

[ 0, 0, 9, 10, 0, 9, 10, 0, 0, 0, 0, 0, 0 ]

[ "Cytomegalovirus", "(", "CMV", ")", "infection", "is", "nonpermissive", "or", "persistent", "in", "many", "lymphoid", "and", "myeloid", "cell", "types", "but", "can", "be", "activated", "in", "differentiated", "macrophages", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 8, 8, 8, 0, 0, 0, 0, 0, 7, 8, 0 ]

[ "Nasal", "NK-", "and", "T-cell", "lymphomas", "share", "the", "same", "type", "of", "Epstein-Barr", "virus", "latency", "as", "nasopharyngeal", "carcinoma", "and", "Hodgkin", "'s", "disease", "." ]

[ 7, 8, 8, 8, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "At", "the", "level", "of", "the", "genomic", "TNF", "gene", ",", "a", "DNase", "I", "hypersensitive", "site", "is", "detected", "within", "the", "TNF", "promoter", "between", "-200", "to", "-100", "bp", "relative", "to", "the", "transcription", "initiation", "site", "." ]

[ 0, 0, 0, 0, 0, 1, 2, 2, 0, 0, 1, 2, 2, 2, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 0 ]

[ "These", "findings", "show", "that", "nuclear", "NF-kappa", "B", "is", "necessary", "to", "activate", "the", "kappa", "B", "enhancer", ",", "while", "KBF1", "by", "itself", "is", "not", "sufficient", "." ]

[ 0, 0, 0, 0, 9, 10, 10, 0, 0, 0, 0, 0, 1, 2, 2, 0, 0, 9, 0, 0, 0, 0, 0, 0 ]

[ "The", "results", "show", "that", "the", "CYP1A1", "mRNA", "level", "induced", "by", "UV", "in", "the", "presence", "of", "tryptophan", "was", "higher", "than", "that", "induced", "by", "UV", "alone", "in", "both", "HaCaT", "cells", "and", "lymphocytes", "after", "3", "h", "of", "incubation", "post-UV", "irradiation", "." ]

[ 0, 0, 0, 0, 0, 3, 4, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 6, 0, 7, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "In", "this", "report", ",", "we", "describe", "the", "cloning", "of", "human", "GATA-4", "(", "hGATA-4", ")", "and", "show", "that", "hGATA-4", "selectively", "interacts", "with", "the", "-70", "GATA", "site", "within", "the", "IL-5", "proximal", "promoter", "region", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 9, 0, 0, 0, 0, 9, 0, 0, 0, 0, 1, 2, 2, 0, 0, 1, 2, 2, 2, 0 ]

[ "Activation", "of", "NF-kappa", "B", "by", "phosphatase", "inhibitors", "involves", "the", "phosphorylation", "of", "I", "kappa", "B", "alpha", "at", "phosphatase", "2A-sensitive", "sites", "." ]

[ 0, 0, 9, 10, 0, 9, 0, 0, 0, 0, 0, 9, 10, 10, 10, 0, 9, 10, 10, 0 ]

[ "These", "results", "suggest", "that", "suppression", "of", "calcineurin", "and", "NFAT", "activation", "is", "a", "mechanism", "by", "which", "oxidative", "stress", "inhibits", "FasL", "induction", "in", "activated", "NK", "cells", "and", "further", "support", "the", "hypothesis", "that", "thiol-reducing", "compounds", "might", "be", "required", "for", "maintenance", "of", "optimal", "NK", "functions", "under", "physiologic", "oxidative", "conditions", "." ]

[ 0, 0, 0, 0, 0, 0, 9, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 7, 8, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Finally", ",", "by", "studying", "a", "further", "series", "of", "patients", ",", "we", "could", "confirm", "that", "the", "decrease", "in", "Rap1", "protein", "expression", "in", "heart", "failure", ",", "whatever", "its", "extent", ",", "was", "variable", ",", "and", "could", "strictly", "correlate", "the", "expression", "of", "Rap1", "protein", "with", "the", "stimulatory", "effect", "of", "C.", "Sub", ".", "on", "Ca2+", "transport", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 9, 10, 10, 0, 0, 0, 0 ]

[ "Thus", ",", "overall", ",", "our", "results", "demonstrate", "that", "a", "PTPase", "is", "involved", "either", "directly", "or", "indirectly", "in", "the", "pathway", "leading", "to", "the", "induction", "of", "endothelial", "cell", "adhesion", "molecules", "by", "TNF", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 0, 9, 0 ]

[ "These", "data", "indicate", "that", "an", "unidentified", "cellular", "factor", "is", "needed", "to", "mediate", "signaling", "by", "the", "EPOR", "." ]

[ 0, 0, 0, 0, 0, 9, 10, 10, 0, 0, 0, 0, 0, 0, 0, 9, 0 ]

[ "In", "Jurkat", "T", "cells", "activated", "by", "phorbol-12-myristate-13-acetate", "and", "phytohemagglutinin", ",", "CCK-8", "induced", "IL-2", "expression", "." ]

[ 0, 5, 6, 6, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0 ]

[ "Nuclei", "from", "GATA-1", "-mutant", "embryonic", "stem", "cells", "can", "still", "be", "reprogrammed", "to", "express", "their", "globin", "genes", "in", "erythroid", "heterokaryons", ",", "indicating", "that", "de", "novo", "induction", "of", "GATA-1", "is", "not", "required", "for", "globin", "gene", "activation", "following", "cell", "fusion", "." ]

[ 0, 0, 5, 6, 6, 6, 6, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0 ]

[ "Viral", "gene", "expression", "may", "be", "reactivated", "by", "stimulation", "of", "the", "cells", "with", "LPS", "or", "cytokines", "such", "as", "TNF-alpha", "in", "vitro", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 9, 0, 0, 0 ]

[ "Despite", "a", "wide", "range", ",", "the", "mean", "GR", "count", "and", "affinity", "in", "MNC", "from", "septic", "patients", "did", "not", "differ", "from", "those", "in", "normal", "controls", ",", "suggesting", "that", "glucocorticoids", "could", "still", "be", "effective", "in", "the", "hemodynamic", "compensatory", "phase", "of", "sepsis", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 7, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Nuclear", "translocation", "of", "NF-kappaB", "subunits", "may", "ultimately", "increase", "the", "intracellular", "pool", "of", "NF-kappaB/IkappaBalpha", "by", "an", "autoregulatory", "mechanism", "." ]

[ 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0 ]

[ "However", ",", "MAPK", "activation", "was", "easily", "detected", "by", "in", "vitro", "kinase", "assays", ",", "after", "FcR", "cross-linking", "with", "immune", "complexes", "." ]

[ 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 9, 10, 0 ]

[ "A", "previously", "unrecognized", "element", ",", "located", "downstream", "of", "the", "start", "site", "of", "transcription", "in", "the", "first", "exon", "of", "the", "DR", "alpha", "gene", ",", "has", "been", "defined", "that", "enhances", "promoter", "activity", "up", "to", "eightfold", "in", "a", "position-dependent", "manner", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 2, 0, 0, 0, 1, 0, 0, 1, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "We", "investigated", "the", "role", "of", "this", "G", "+", "C-rich", "region", "in", "augmenting", "alpha-globin", "promoter", "activity", "in", "the", "presence", "of", "the", "far-upstream", "alpha-globin", "enhancer", ",", "HS-40", "." ]

[ 0, 0, 0, 0, 0, 0, 1, 2, 2, 2, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 1, 2, 2, 0, 1, 0 ]

[ "Run-on", "analysis", "demonstrated", "detectable", "levels", "of", "c-jun", "transcription", "in", "U-937", "cells", "and", "that", "this", "rate", "is", "increased", "approximately", "40-fold", "following", "okadaic", "acid", "exposure", "." ]

[ 0, 0, 0, 0, 0, 0, 1, 0, 0, 5, 6, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "The", "class", "II", "trans-activator", "(", "CIITA", ")", "is", "a", "bi-", "or", "multi-functional", "domain", "protein", "which", "plays", "a", "critical", "role", "in", "the", "expression", "of", "MHC", "class", "II", "genes", "." ]

[ 0, 9, 10, 10, 0, 9, 0, 0, 0, 9, 10, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 2, 0 ]

[ "Study", "of", "Aldh1", "gene", "expression", "during", "spleen", "development", "showed", "that", "the", "presence", "of", "Aldh1", "mRNA", "inversely", "correlated", "with", "Hox11", "." ]

[ 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 4, 0, 0, 0, 9, 0 ]

[ "The", "ras", "mutation", "frequency", "varies", "between", "95", "%", "in", "pancreatic", "cancer", "and", "5", "%", "in", "breast", "cancer", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "These", "results", "suggest", "that", "in", "human", "T", "lymphocytes", "both", "Dex", "and", "CsA", "inhibited", "IL-2", "gene", "transcription", "through", "interference", "with", "transcription", "factors", "AP-1", "and", "NF-AT", "." ]

[ 0, 0, 0, 0, 0, 7, 8, 8, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 9, 10, 9, 0, 9, 0 ]

[ "Using", "electrophoretic", "mobility", "shift", "assays", ",", "we", "have", "studied", "these", "transcription", "factors", "in", "primary", "T", "cells", "from", "human", "blood", "to", "verify", "their", "presence", "in", "a", "physiologic", "setting", "and", "to", "identify", "the", "signals", "that", "stimulate", "factor", "activity", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 7, 8, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Thus", ",", "the", "GAS", "sequence", "in", "the", "CAEV", "LTR", "is", "essential", "for", "the", "response", "to", "IFN-gamma", "and", "a", "STAT1-like", "factor", "binds", "to", "this", "site", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 9, 0, 0, 9, 10, 0, 0, 0, 0, 0 ]

[ "Indeed", ",", "USA-derived", "PC2", "was", "found", "to", "act", "synergistically", "with", "PC4", "in", "reproducing", "the", "function", "of", "intact", "USA", "in", "the", "assay", "system", "." ]

[ 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Furthermore", ",", "it", "demonstrates", "that", "aging", "does", "not", "influence", "the", "sensitivity", "of", "this", "phosphatase", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0 ]

[ "However", ",", "TGF-beta", "1", "did", "not", "induce", "dephosphorylation", "of", "pRb", "in", "EBV", "(", "or", "LMP-1", ")", "-positive", "cells", "as", "opposed", "to", "EBV-negative", "cells", ",", "suggesting", "a", "dichotomy", "in", "the", "TGF-beta", "1", "signaling", "pathway", "leading", "to", "separable", "gene", "regulatory", "and", "growth", "inhibitory", "responses", "." ]

[ 0, 0, 9, 10, 0, 0, 0, 0, 0, 9, 0, 5, 6, 6, 6, 6, 6, 6, 0, 0, 0, 5, 6, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Lymphocyte", "infiltration", "of", "tumor", "was", "studied", "vis-a-vis", "hormone", "metabolic", "status", ",", "tumor", "tissue", "hormone", "sensitivity", "and", "tobacco", "smoking", ",", "in", "113", "breast", "cancer", "patients", ",", "aged", "25-77", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "HIV-1", "reactivation", "in", "resting", "peripheral", "blood", "mononuclear", "cells", "of", "infected", "adults", "upon", "in", "vitro", "CD4", "cross-linking", "by", "ligands", "of", "the", "CDR2-loop", "in", "extracellular", "domain", "1", "." ]

[ 0, 0, 0, 7, 8, 8, 8, 8, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 9, 0, 9, 10, 10, 0 ]

[ "In", "the", "same", "experiments", ",", "all", "three", "non-", "B-cell", "lines", "showed", "NF-kappa", "B", "activation", "and", "ICAM-1", "upregulation", "but", "never", "any", "effect", "upon", "Bcl-2", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 5, 6, 0, 9, 10, 0, 0, 9, 0, 0, 0, 0, 0, 0, 9, 0 ]

[ "Stimulation", "of", "DND39", "cells", "with", "IL-4", "or", "anti-CD40", "monoclonal", "antibody", "(", "mAb", ")", "activated", "phosphatidylinositol", "3-kinase", "and", "subsequently", "induced", "nuclear", "expression", "of", "NF-kappa", "B", ",", "which", "was", "identified", "by", "electrophoretic", "mobility", "shift", "assays", "." ]

[ 0, 0, 5, 6, 0, 9, 0, 9, 10, 10, 0, 9, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Activation", "of", "the", "Jak", "-Stat", "pathway", "correlates", "with", "proliferative", "signaling", "by", "the", "G-CSFR", "and", "requires", "the", "membrane-proximal", "box", "1", "PXP", "motif", ",", "which", "is", "conserved", "in", "members", "of", "the", "cytokine", "receptor", "superfamily", "." ]

[ 0, 0, 0, 9, 9, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 9, 10, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0 ]

[ "It", "is", "clear", "that", "sufficient", "numbers", "of", "functional", "glucocorticoid", "receptors", "are", "required", "to", "mediate", "lysis", ",", "but", "whether", "they", "do", "so", "through", "the", "classical", "model", "of", "steroid", "hormone", "activation", "and", "modulation", "of", "gene", "expression", "has", "not", "been", "established", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Since", "sequence", "variations", "in", "the", "3", "'", "UTR", "of", "VDR", "have", "been", "linked", "to", "the", "different", "haplotypes", ",", "investigators", "have", "proposed", "that", "the", "stability", "of", "VDR", "mRNA", "is", "influenced", "by", "allelic", "variations", "." ]

[ 0, 1, 2, 0, 0, 1, 2, 2, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 4, 0, 0, 0, 0, 0, 0 ]

[ "The", "Legionella", "pneumophila", "rpoS", "gene", "is", "required", "for", "growth", "within", "Acanthamoeba", "castellanii", "." ]

[ 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "The", "nuclear", "body", "(", "NB", ")", "is", "a", "cellular", "organelle", "that", "is", "involved", "in", "the", "pathogenesis", "of", "acute", "promyelocytic", "leukemia", "and", "viral", "infection", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "This", "finding", "suggests", "that", "the", "BZLF1", "promoter", "may", "be", "regulated", "by", "the", "degree", "of", "squamous", "differentiation", "." ]

[ 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Whereas", "AP-1", ",", "NF-kappa", "B", ",", "Oct", ",", "CREB", "and", "SP1", "displayed", "normal", "binding", "activities", "in", "nuclear", "extracts", ",", "the", "binding", "of", "NF-AT", "to", "its", "IL-2", "promoter", "response", "element", "was", "barely", "detectable", "both", "before", "and", "after", "T", "cell", "stimulation", "." ]

[ 0, 9, 0, 0, 0, 0, 9, 0, 9, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "The", "development", "of", "improved", "glucocorticoid-based", "drugs", "will", "require", "the", "separation", "of", "beneficial", "from", "deleterious", "effects", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Furthermore", ",", "we", "confirmed", "the", "previous", "report", "that", "FK506", "suppressed", "the", "PMA/ionomycin-induced", "activation", "through", "authentic", "kappa", "B", "site", "of", "immunoglobulin", "(", "Ig", ")", "gene", ",", "to", "which", "NF-kappa", "B", "binding", "was", "also", "decreased", "by", "FK506", ",", "indicating", "that", "both", "IL-8", "kappa", "B-like", "site", "and", "Ig", "kappa", "B", "site", "are", "FK506-sensitive", "in", "spite", "of", "the", "difference", "of", "binding", "factors", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 0, 1, 2, 2, 2, 2, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 2, 0, 0, 1, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0 ]

[ "These", "results", "provided", "evidence", "that", "c-Myc", "and", "E1A", "activated", "the", "NK", "cell", "induced", "cytolysis", "at", "a", "post-triggering", "stage", "of", "NK", "cell-target", "cell", "interaction", "." ]

[ 0, 0, 0, 0, 0, 9, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Signal", "transducers", "and", "activators", "of", "transcription", "(", "STATs", ")", "are", "rapidly", "phosphorylated", "on", "tyrosine", "residues", "in", "response", "to", "cytokine", "and", "growth", "factor", "stimulation", "of", "cell", "surface", "receptors", "." ]

[ 9, 10, 10, 10, 10, 10, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 9, 10, 0, 0, 9, 10, 10, 0 ]

[ "We", "have", "found", "recently", "that", "okadaic", "acid-sensitive", "Ser/Thr", "phosphatases", "are", "involved", "in", "a", "cyclosporin", "A-insensitive", "pathway", "that", "selectively", "transmits", "costimulatory", "signals", "." ]

[ 0, 0, 0, 0, 0, 9, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Little", "is", "known", "about", "how", "the", "very", "early", "events", "induced", "by", "CD40", "cross-linking", "link", "to", "cellular", "responses", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0 ]

[ "Signal", "requirements", "and", "characterization", "by", "western", "blots", "and", "DNA", "sequencing", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "The", "degree", "of", "negative", "autoregulation", "in", "IM-9", "cells", "and", "positive", "autoregulation", "in", "6TG1.1", "cells", "was", "unaffected", "by", "inhibition", "of", "protein", "synthesis", "with", "cycloheximide", "." ]

[ 0, 0, 0, 0, 0, 0, 5, 6, 0, 0, 0, 0, 5, 6, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Severe", "5-fluorouracil", "toxicity", "secondary", "to", "dihydropyrimidine", "dehydrogenase", "deficiency", "." ]

[ 0, 0, 0, 0, 0, 9, 10, 0, 0 ]