id
stringlengths
1
5
tokens
sequence
ner_tags
sequence
85
[ "The", "cell", "cycle-dependent", "transcription", "factor", ",", "E2F-1", ",", "regulates", "the", "cyclin", "-like", "species", "of", "the", "DNA", "repair", "enzyme", "uracil-DNA", "glycosylase", "(", "UDG", ")", "gene", "in", "human", "osteosarcoma", "(", "Saos-2", ")", "cells", "." ]
[ 0, 9, 10, 10, 10, 0, 9, 0, 0, 0, 9, 0, 0, 0, 0, 9, 10, 10, 1, 2, 2, 2, 2, 2, 0, 5, 6, 6, 6, 6, 6, 0 ]
13523
[ "We", "show", "that", "increased", "transcription", "of", "the", "NF-IL6", "gene", "is", "responsible", ",", "at", "least", "in", "part", ",", "for", "induction", "of", "NF-IL6", "mRNA", "following", "activation", "of", "U937", "promonocytic", "cells", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 4, 0, 0, 0, 5, 6, 6, 0 ]
12260
[ "The", "discrepancy", "in", "the", "degree", "of", "inhibition", "by", "membrane", "extracts", "and", "NK", "cells", "with", "mutant", "TNFRI", "suggests", "that", "additional", "pathways", "are", "utilized", "by", "NK", "cells", "to", "activate", "EC" ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0, 0, 7 ]
9906
[ "While", "these", "compounds", "affect", "various", "cellular", "processes", ",", "current", "data", "do", "not", "fully", "explain", "how", "sesquiterpene", "lactones", "exert", "their", "anti-inflammatory", "effect", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
5551
[ "Copyright", "1999", "Wiley-Liss", ",", "Inc", "." ]
[ 0, 0, 0, 0, 0, 0 ]
1089
[ "Furthermore", ",", "we", "show", "that", "retinoic", "acid", "can", "also", "induce", "apoptosis", "in", "these", "cells", "through", "the", "retinoic", "acid", "receptor", ",", "whose", "repressive", "functions", "but", "not", "target", "site", "specificity", ",", "are", "similar", "to", "those", "of", "the", "glucocorticoid", "receptor", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0 ]
1059
[ "Human", "immunodeficiency", "virus", "type", "1", "(", "HIV-1", ")", "replication", "is", "controlled", "by", "a", "complex", "array", "of", "virally", "encoded", "and", "cellular", "proteins", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 10, 0 ]
10359
[ "In", "these", "cells", ",", "Stat6", "activation", "led", "to", "the", "induction", "of", "the", "beta-casein", "gene", "promoter", "." ]
[ 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 0 ]
4584
[ "IL-2", "production", "by", "CsA-treated", "cells", "is", "therefore", "dramatically", "reduced", "." ]
[ 9, 0, 0, 5, 6, 0, 0, 0, 0, 0 ]
13395
[ "We", "have", "tested", "this", "possibility", "directly", "using", "TAP-deficient", "cell", "lines", "lacking", "antigenic", "ER", "peptides", "derived", "from", "two", "model", "Ags", ",", "the", "human", "adenovirus", "type", "5", "early", "regions", "E1A", "and", "E1B", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 5, 6, 6, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 9, 10, 10, 10, 10, 10, 10, 10, 10, 0 ]
2069
[ "When", "cells", "were", "preincubated", "with", "dihydrolipoic", "acid", "(", "0.2", "mM", ")", "the", "expression", "of", "c-fos", "mRNA", "was", "suppressed", "at", "30", "min", "after", "stimulation", "of", "TPA", "(", "0.5", "microM", ")", "whereas", "in", "the", "case", "of", "preincubation", "of", "alpha-lipoic", "acid", "(", "0.2", "microM", ")", ",", "the", "expression", "was", "enhanced", "at", "30", "min", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 4, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
11202
[ "We", "have", "previously", "demonstrated", "an", "obligatory", "requirement", "for", "intracellular", "reactive", "oxygen", "species", "generation", "during", "T", "lymphocyte", "activation", ",", "and", "have", "proposed", "that", "intracellular", "reactive", "oxygen", "species", "may", "act", "as", "signalling", "agents", "in", "the", "regulation", "of", "certain", "cellular", "processes", ",", "for", "example", ",", "during", "cell", "cycle", "entry", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
7149
[ "These", "observations", "suggest", "a", "biological", "significance", "for", "different", "mechanisms", "of", "IL-2", "activation", "in", "initiation", "and", "maintenance", "of", "the", "cytokine", "repertoire", "found", "in", "the", "mucosa", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0 ]
3019
[ "The", "predicted", "amino", "acid", "sequence", "of", "the", "amino-terminal", "portion", "of", "Sp140", "was", "similar", "to", "Sp100", ",", "a", "previously", "identified", "NB", "protein", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 9, 0, 0, 0, 9, 0, 0, 0, 0, 9, 10, 0 ]
1075
[ "Whether", "virus-induced", "NF-kappa", "B", "activation", "is", "a", "mechanism", "that", "favors", "continuous", "viral", "replication", "in", "macrophages", "remains", "unknown", "." ]
[ 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 0, 0, 0 ]
9132
[ "A", "unique", "subclone", "of", "a", "bone", "marrow-derived", "stromal", "cell", "line", ",", "BMS2.4", ",", "produces", "soluble", "factors", "that", "inhibit", "proliferation", "of", "several", "types", "of", "hematopoietic", "cell", "lines", "." ]
[ 0, 0, 0, 0, 0, 5, 6, 6, 6, 6, 0, 5, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 5, 6, 6, 0 ]
1759
[ "We", "conclude", "that", "although", "neither", "of", "the", "two", "5'-most", "Ets", "sites", "alone", "binds", "nuclear", "protein", ",", "they", "appear", "to", "act", "as", "modulators", "which", "control", "the", "pattern", "of", "Ets", "proteins", "that", "bind", "the", "alpha", "4", "gene", "promoter", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 1, 2, 2, 2, 0 ]
4842
[ "An", "electrophoretic", "mobility", "shift", "assay", "(", "EMSA", ")", "with", "nuclear", "extract", "from", "activated", "T", "cells", "and", "an", "oligonucleotide", "of", "this", "binding", "site", "demonstrated", "a", "new", "protein-DNA", "complex", ",", "referred", "to", "as", "CMAT", "for", "c-myb", "in", "activated", "T", "cells", ";", "this", "complex", "was", "not", "present", "in", "unactivated", "T", "cells", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 9, 0, 9, 10, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 7, 8, 8, 0 ]
5535
[ "IkappaBalpha", "phosphorylation", "and", "degradation", "was", "analyzed", "by", "Western", "blot", "." ]
[ 9, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
11699
[ "The", "Pax-5", "gene", "is", "alternatively", "spliced", "during", "B-cell", "development", "." ]
[ 0, 1, 2, 0, 0, 0, 0, 0, 0, 0 ]
7430
[ "Cloning", "of", "the", "5", "'", "and", "3", "'", "untranslated", "region", "(", "UTR", ")", "of", "human", "keratinocyte", "PCD/DCoH", "revealed", "that", "it", "has", "53", "bp", "more", "of", "GC-rich", "5", "'", "untranslated", "sequence", "than", "the", "published", "liver", "PCD/DCoH", "." ]
[ 0, 0, 0, 1, 2, 2, 2, 2, 2, 2, 0, 1, 0, 0, 9, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 2, 2, 0, 0, 0, 9, 10, 0 ]
16924
[ "Retroviral", "mediated", "transfer", "and", "expression", "of", "exogenous", "genes", "in", "primary", "lymphoid", "cells", ":", "assaying", "for", "a", "viral", "transactivator", "activity", "in", "normal", "and", "malignant", "cells", "." ]
[ 0, 0, 0, 0, 0, 0, 1, 2, 0, 7, 8, 8, 0, 0, 0, 0, 0, 9, 0, 0, 7, 8, 8, 8, 0 ]
12979
[ "In", "both", "cases", ",", "peptide", "presentation", "to", "T", "cells", "via", "class", "II", "molecules", "was", "restricted", "to", "the", "basolateral", "surface", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 7, 8, 0, 9, 10, 10, 0, 0, 0, 0, 0, 0, 0 ]
5783
[ "This", "was", "not", "observed", "when", "the", "NFAT-1", "mutant", "LTR", "was", "activated", "by", "mitogen", "." ]
[ 0, 0, 0, 0, 0, 0, 1, 2, 2, 0, 0, 0, 9, 0 ]
12424
[ "Heterogeneous", "expression", "of", "the", "lipocalin", "NGAL", "in", "primary", "breast", "cancers", "." ]
[ 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0 ]
8396
[ "Expression", "studies", "revealed", "that", "HMG-I", "(", "Y", ")", "is", "ubiquitously", "expressed", "in", "human", "tissues", "that", "do", "not", "express", "beta-globin", ",", "being", "present", "in", "48", "of", "50", "tissues", "and", "six", "hematopoietic", "cell", "lines", "examined", "." ]
[ 0, 0, 0, 0, 9, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 6, 6, 0, 0 ]
3517
[ "B", "lymphocytes", "from", "the", "peripheral", "blood", "of", "patients", "with", "chronic", "lymphocytic", "leukaemia", "(", "CLL", ")", "were", "analysed", "for", "the", "nuclear", "presence", "and", "DNA", "binding", "of", "a", "panel", "of", "transcription", "factors", "which", "are", "involved", "in", "the", "gene", "control", "of", "lymphoid", "cells", "." ]
[ 7, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0 ]
7231
[ "Additional", "signaling", "molecules", "that", "contribute", "to", "the", "formation", "of", "normal", "lymphoid", "tissue", "structure", "are", "being", "identified", "at", "an", "accelerating", "pace", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
13007
[ "To", "characterize", "further", "the", "function", "of", "the", "intracellular", "vitamin", "D", "receptor", "(", "VDR", ")", ",", "we", "have", "developed", "stable", "transfectant", "variants", "of", "a", "vitamin", "D-responsive", "cell", "line", "(", "U937", ")", "which", "express", "either", "decreased", "or", "increased", "numbers", "of", "VDR", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 0, 9, 0, 0, 0, 0, 0, 5, 6, 6, 0, 0, 5, 6, 6, 6, 0, 5, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0 ]
123
[ "alpha", "B", "is", "the", "mouse", "homologue", "of", "human", "AML1", "gene", "detected", "at", "the", "breakpoints", "of", "t", "(", "8", ";", "21", ")", "and", "t", "(", "3", ";", "21", ")", "myeloid", "leukemias", "." ]
[ 1, 2, 0, 0, 1, 2, 0, 1, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
9528
[ "Transcriptional", "activation", "of", "the", "vascular", "cell", "adhesion", "molecule-1", "gene", "in", "T", "lymphocytes", "expressing", "human", "T-cell", "leukemia", "virus", "type", "1", "Tax", "protein", "." ]
[ 0, 0, 0, 0, 1, 2, 2, 2, 2, 0, 7, 8, 0, 9, 10, 10, 10, 10, 10, 10, 10, 0 ]
10949
[ "Clonal", "analysis", "revealed", "individual", "responses", "to", "the", "two", "immediate", "early", "proteins", "BZLF1", "and", "BRLF1", ",", "and", "to", "three", "(", "BMLF1", ",", "BMRF1", ",", "and", "BALF2", ")", "of", "the", "six", "early", "proteins", "tested", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 9, 0, 9, 0, 0, 0, 0, 0, 9, 0, 9, 0, 0, 9, 0, 0, 0, 0, 9, 10, 0, 0 ]
4736
[ "Triplex", "formation", "by", "GM3", "blocked", "recombinant", "and", "nuclear", "NF-kappaB", "proteins", "binding", "to", "the", "GM-CSF", "element", "." ]
[ 0, 0, 0, 0, 0, 9, 10, 10, 10, 10, 0, 0, 0, 1, 2, 0 ]
15706
[ "The", "proto-oncoprotein", "c-Rel", "is", "a", "member", "of", "the", "nuclear", "factor", "kappa", "B", "transcription", "factor", "family", ",", "which", "includes", "the", "p50", "and", "p65", "subunits", "of", "nuclear", "factor", "kappa", "B", "." ]
[ 0, 9, 10, 0, 0, 0, 0, 0, 9, 10, 10, 10, 10, 10, 10, 0, 0, 0, 0, 9, 0, 9, 10, 0, 9, 10, 10, 10, 0 ]
14934
[ "These", "observations", "indicate", "that", "expression", "of", "Egr-1", "is", "essential", "for", "and", "restricts", "differentiation", "of", "myeloblasts", "along", "the", "macrophage", "lineage", "." ]
[ 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 7, 0, 0, 7, 8, 0 ]
358
[ "Induction", "of", "VCAM-1", "and", "E-selectin", "surface", "expression", "by", "TNF", "was", "dose-dependently", "reduced", "by", "aspirin", "over", "the", "same", "range", ",", "while", "induction", "of", "intercellular", "adhesion", "molecule-1", "(", "ICAM-1", ")", "was", "hardly", "affected", "." ]
[ 0, 0, 9, 0, 9, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 9, 0, 0, 0, 0, 0 ]
519
[ "Here", ",", "we", "demonstrate", "that", "CIITA", "is", "an", "MHC", "class", "II", "gene-specific", "transcription", "activator", "." ]
[ 0, 0, 0, 0, 0, 1, 0, 0, 1, 2, 2, 2, 2, 2, 0 ]
3209
[ "PRRIII", "contains", "a", "Stat", "protein", "binding", "site", "that", "overlaps", "with", "an", "EBS", "motif", "(", "GASd/EBSd", ")", "." ]
[ 1, 0, 0, 1, 2, 2, 2, 0, 0, 0, 0, 1, 2, 0, 1, 0, 0 ]
4073
[ "DNase", "I", "hypersensitive", "site", "(", "DHS", ")", "mapping", "revealed", "that", "the", "perforin", "locus", "contained", "six", "DHS", "within", "7.0", "kb", "of", "the", "5", "'", "upstream", "sequence", "(", "-7.0", "kb", ")", "and", "two", "DHS", "in", "intron", "2", "." ]
[ 1, 2, 2, 2, 0, 1, 0, 0, 0, 0, 0, 1, 2, 0, 0, 1, 0, 0, 0, 0, 0, 1, 2, 2, 2, 0, 0, 0, 0, 0, 0, 1, 0, 1, 2, 0 ]
4169
[ "Sialoadhesin", "is", "a", "macrophage-restricted", "member", "of", "the", "Ig", "superfamily", "that", "mediates", "adhesion", "with", "lymphoid", "and", "myeloid", "cells", "." ]
[ 9, 0, 0, 9, 10, 0, 0, 9, 10, 0, 0, 0, 0, 7, 8, 8, 8, 0 ]
1159
[ "RESULTS", ":", "The", "results", "showed", "high", "GATA-1", "binding", "activity", "and", "very", "low", "SP1", "activity", "in", "the", "fetal", "liver", "cultures", "." ]
[ 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 9, 0, 0, 0, 5, 6, 6, 0 ]
5991
[ "MCP-1", "RNA", "level", "was", "also", "increased", "in", "RA-treated", "cells", "." ]
[ 3, 4, 0, 0, 0, 0, 0, 0, 0, 0 ]
12313
[ "In", "addition", ",", "X-ray", "activation", "of", "HIV-1", "LTR", "in", "transiently", "or", "stably", "transfected", "cell", "lines", "is", "inhibited", "by", "a", "potent", "antioxidant", "drug", ",", "pyrrolidine", "dithiocarbamate", "and", "by", "another", "drug", ",", "known", "for", "its", "role", "in", "the", "trapping", "of", "growth", "factors", ",", "suramin", "." ]
[ 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 5, 6, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0 ]
14527
[ "This", "intracellular", "signaling", "complex", "potently", "stimulates", "kappa", "B-directed", "transcription", "from", "either", "the", "HIV-1", "LTR", "or", "the", "IL-2R", "alpha", "promoter", "via", "the", "strong", "transactivation", "domain", "present", "in", "p65", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 1, 2, 2, 0, 0, 0, 0, 0, 0, 0, 9, 0 ]
13877
[ "The", "lymphocytes", "exhibited", "lipid", "peroxidation", "only", "upon", "exposure", "to", "the", "lowest", "level", "of", "hydrogen", "peroxide", "used", "(", "20", "microM", ")", "." ]
[ 0, 7, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
8128
[ "Taken", "together", ",", "these", "results", "suggest", "that", "NF-kappa", "B", "plays", "a", "crucial", "role", "in", "ensuring", "the", "differentiation", "and", "survival", "of", "thymocytes", "in", "the", "early", "stages", "of", "their", "development", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 0, 0, 0, 0, 0, 0, 0, 0 ]
998
[ "During", "the", "induction", "of", "anergy", ",", "T", "cells", "are", "phenotypically", "similar", "to", "cells", "responding", "to", "an", "immunogenic", "stimulus", "." ]
[ 0, 0, 0, 0, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
18287
[ "Human", "IL4", "promoter", "-mediated", "transcription", "is", "downregulated", "in", "Jurkat", "cells", "stimulated", "with", "the", "NF-kappa", "B-activating", "cytokine", "tumor", "necrosis", "factor", "alpha", "and", "suppressed", "in", "RelA-overexpressing", "cells", "." ]
[ 1, 2, 2, 0, 0, 0, 0, 0, 5, 6, 0, 0, 0, 9, 10, 10, 9, 10, 10, 10, 0, 0, 0, 5, 6, 0 ]
11844
[ "T-lymphocytes", "from", "individuals", "with", "filarial", "inflammatory", "disease", "have", "increased", "transendothelial", "migration", "in", "vitro", "." ]
[ 7, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
14302
[ "The", "presence", "of", "mRNA", "for", "these", "proteins", "in", "eosinophils", "and", "basophils", "suggests", "that", "gene", "transcription", "in", "these", "lineages", "may", "be", "regulated", "by", "GATA-binding", "proteins", "." ]
[ 0, 0, 0, 3, 0, 0, 0, 0, 7, 0, 7, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0 ]
9445
[ "Results", "were", "expressed", "as", "a", "median", "(", "interquartile", "range", ")", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
10332
[ "In", "this", "report", "we", "present", "the", "characterisation", "of", "NF-kappaB", "subunits", "engaged", "in", "complexes", "binding", "to", "the", "HIV-1", "NF-kappaB", "site", "in", "human", "8e51", "T-cells", ",", "that", "harbour", "a", "defective", "HIV-1", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 1, 2, 2, 0, 5, 6, 6, 0, 0, 0, 0, 0, 0, 0 ]
17908
[ "Flutamide", "affects", "androgen", "receptor", "behavior", "during", "the", "menstrual", "cycle", "." ]
[ 0, 0, 9, 10, 0, 0, 0, 0, 0, 0 ]
11990
[ "Nonetheless", ",", "only", "a", "limited", "portion", "of", "the", "cytoplasmic", "domain", "of", "gamma", "(", "c", ")", "is", "necessary", "for", "IL-7R", "signal", "transduction", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 9, 10, 10, 10, 0, 0, 0, 9, 0, 0, 0 ]
9693
[ "Intragenic", "TSG101", "deletions", "in", "RNA", "transcripts", "were", "frequently", "found", "in", "all", "types", "of", "samples", "." ]
[ 0, 1, 0, 0, 3, 4, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
300
[ "The", "control", "group", "consisted", "of", "24", "healthy", "laboratory", "employees", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
10393
[ "Biphasic", "control", "of", "NF-kappa", "B", "activation", "induced", "by", "the", "triggering", "of", "HLA-DR", "antigens", "expressed", "on", "B", "cells", "." ]
[ 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 7, 8, 0 ]
5260
[ "Investigation", "of", "these", "factors", "promises", "to", "shed", "light", "on", "the", "complex", "development", "pathways", "involved", "in", "the", "regulation", "of", "haematopoiesis", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
5373
[ "In", "contrast", ",", "anergic", "CD4+", "T", "cells", "contained", "severely", "reduced", "levels", "of", "AP-1", "and", "Fos/Jun-containing", "NF-AT", "complexes", "but", "expressed", "significant", "amounts", "of", "NF-kappa", "B", "and", "Oct", "binding", "proteins", "after", "SEA", "stimulation", "." ]
[ 0, 0, 0, 7, 8, 8, 8, 0, 0, 0, 0, 0, 9, 0, 9, 10, 10, 0, 0, 0, 0, 0, 9, 10, 0, 9, 10, 10, 0, 9, 0, 0 ]
9153
[ "In", "this", "study", "we", "investigated", "the", "effects", "of", "C3a", "and", "C3a", "(", "desArg", ")", "on", "gene", "expression", "and", "protein", "secretion", "of", "IL-6", "in", "human", "PBMCs", ",", "either", "alone", "or", "in", "combination", "with", "LPS", "or", "IL-1beta", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 9, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 7, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0 ]
14476
[ "LPS", "activation", "of", "THP-1", "cells", "resulted", "in", "phosphorylation", "of", "MAD3", "(", "an", "I", "kappa", "B", "-like", "protein", ")", ",", "a", "rapid", "increase", "in", "MAD3", "mRNA", ",", "and", "an", "increase", "in", "MAD3", "protein", "by", "2", "h", "." ]
[ 0, 0, 0, 5, 6, 0, 0, 0, 0, 9, 0, 0, 9, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 3, 4, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0 ]
15741
[ "It", "is", "also", "evident", "that", "the", "TF.VIIa", "complex", "is", "proteolytically", "active", "and", "can", "activate", "the", "zymogen", "plasma", "factor", "X", "to", "the", "serine", "protease", "Xa", "in", "free", "solution", ",", "inferring", "that", "extended", "substrate", "recognition", "by", "induced", "structural", "loci", "of", "the", "TF.VIIa", "complex", "are", "created", "from", "either", "or", "both", "proteins", "to", "constitute", "a", "new", "recognition", "structure", "." ]
[ 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 0, 0, 9, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0 ]
2993
[ "Since", "APL", "cells", "do", "not", "express", "HLA", "class", "II", "molecules", ",", "we", "tested", "in", "two", "donors", "(", "D.E.", "and", "C.H.R.", ")", "and", "in", "patients", "S.R.and", "P.G.whether", "the", "use", "of", "9-mer", "peptides", "(", "BCR1/9", ")", "would", "generate", "a", "CD8", "/HLA", "class", "I", "-restricted", "response", "." ]
[ 0, 5, 6, 0, 0, 0, 9, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 9, 10, 10, 0, 0, 0 ]
3642
[ "These", "results", "indicate", "that", "E3", "is", "a", "hematopoietic-specific", "gene", "that", "is", "an", "immediate", "target", "for", "the", "activated", "RAR", "alpha", "during", "myelopoiesis", "." ]
[ 0, 0, 0, 0, 9, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0 ]
8421
[ "The", "maximum", "(", "3H", ")", "-thymidine", "incorporation", "into", "DNA", "of", "cord", "blood", "lymphocytes", "from", "all", "preterms", ",", "with", "or", "without", "NRDS", "was", "suppressed", "when", "compared", "to", "that", "from", "term", "babies", "or", "adults", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
12410
[ "Dexamethasone", "inhibits", "binding", "to", "the", "Ikaros", "and", "AP-1", "regulatory", "elements", "of", "the", "granzyme", "B", "promoter", "." ]
[ 0, 0, 0, 0, 0, 9, 0, 1, 2, 2, 0, 0, 1, 2, 2, 0 ]
14225
[ "Transcription", "of", "the", "human", "beta-globin", "gene", "cluster", "depends", "upon", "upstream", "regulatory", "sequences", ",", "which", "are", "collectively", "termed", "the", "locus", "control", "region", "." ]
[ 0, 0, 0, 1, 2, 2, 2, 0, 0, 1, 2, 2, 0, 0, 0, 0, 0, 0, 1, 2, 2, 0 ]
4854
[ "However", ",", "synthesis", "of", "the", "26-kDa", "membrane", "form", "of", "TNF", "was", "effectively", "blocked", "by", "CNI-1493", "." ]
[ 0, 0, 0, 0, 0, 9, 10, 10, 0, 9, 0, 0, 0, 0, 0, 0 ]
6737
[ "The", "distribution", "of", "immunoglobulin", "M", "(", "IgM", ")", "-", ",", "IgD-", ",", "and", "IgG-positive", "cells", "and", "the", "expression", "patterns", "of", "Ki-67", ",", "CD23", ",", "or", "bcl-2", "and", "bcl-6", "gene", "products", "in", "the", "follicles", "with", "GC", "formation", "in", "the", "liver", "of", "patients", "with", "chronic", "hepatitis", "C", "were", "similar", "to", "those", "of", "lymph", "nodes", ",", "indicating", "that", "B", "cells", "are", "activated", ",", "proliferated", ",", "and", "differentiated", "in", "the", "ILFs", "with", "GC", "formation", "in", "patients", "with", "chronic", "hepatitis", "C", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
17772
[ "Add-back", "experiments", "with", "either", "cytokines", "(", "IL-2", "or", "IL-6", ")", ",", "LTB4", "or", "conditioned", "media", "failed", "to", "restore", "the", "proliferative", "response", "in", "the", "presence", "of", "tepoxalin", "." ]
[ 0, 0, 0, 0, 9, 0, 9, 0, 9, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
10914
[ "Treatment", "of", "cells", "expressing", "the", "chimeric", "receptor", "kit/IL-4R", "alpha", "with", "SCF", "induces", "activation", "of", "the", "IL-4R", "alpha-associated", "kinase", "JAK-1", "and", "the", "transcription", "factor", "STAT6", "." ]
[ 0, 0, 0, 0, 0, 9, 10, 9, 10, 0, 9, 0, 0, 0, 0, 9, 10, 10, 9, 0, 0, 9, 10, 9, 0 ]
7078
[ "In", "addition", "to", "activating", "transcription", "from", "the", "viral", "long", "terminal", "repeat", "(", "LTR", ")", "through", "the", "cyclic", "AMP", "response", "element", "binding", "protein/activating", "transcription", "factor", "(", "CREB/ATF", ")", "family", "of", "transcription", "factors", ",", "Tax", "activates", "the", "expression", "of", "multiple", "cellular", "promoters", "through", "the", "NF-kappaB", "pathway", "of", "transcriptional", "activation", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 2, 0, 1, 0, 0, 0, 9, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 0, 9, 10, 0, 9, 0, 0, 0, 0, 1, 2, 2, 0, 0, 9, 0, 0, 0, 0, 0 ]
681
[ "Does", "activation", "of", "the", "TAL1", "gene", "occur", "in", "a", "majority", "of", "patients", "with", "T-cell", "acute", "lymphoblastic", "leukemia", "?", "A", "pediatric", "oncology", "group", "study", "." ]
[ 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
6740
[ "Downregulation", "of", "Wilms", "'", "tumor", "gene", "(", "WT1", ")", "is", "not", "a", "prerequisite", "for", "erythroid", "or", "megakaryocytic", "differentiation", "of", "the", "leukemic", "cell", "line", "K562", "." ]
[ 0, 0, 1, 2, 2, 2, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 6, 6, 6, 0 ]
7949
[ "Glucocorticoid", "hormone", "suppression", "of", "human", "neutrophil", "-mediated", "tumor", "cell", "cytostasis", "." ]
[ 0, 0, 0, 0, 0, 7, 0, 0, 0, 0, 0 ]
13563
[ "Two", "pyrrole-imidazole", "polyamides", "were", "designed", "to", "bind", "DNA", "sequences", "immediately", "adjacent", "to", "binding", "sites", "for", "the", "transcription", "factors", "Ets-1", ",", "lymphoid-enhancer", "binding", "factor", "1", ",", "and", "TATA-box", "binding", "protein", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 9, 0, 9, 10, 10, 10, 0, 0, 9, 10, 10, 0 ]
9443
[ "MATERIALS", "AND", "METHODS", ":", "Eleven", "patients", "with", "ulcerative", "colitis", "(", "5", "who", "responded", "to", "intravenous", "glucocorticoids", "and", "6", "who", "did", "not", ")", "and", "ten", "control", "subjects", "were", "studied", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
3976
[ "The", "activity", "was", "tested", "by", "quantitating", "the", "nuclear", "proteins", "binding", "to", "an", "oligonucleotide", "containing", "the", "consensus", "kappa", "B", "binding", "sequence", "(", "electrophoretic", "mobility", "shift", "assay", ")", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 1, 2, 2, 2, 2, 0, 0, 0, 0, 0, 0, 0 ]
10717
[ "The", "T-cell", "receptor", "(", "TCR", ")", "beta-chain", "promoters", "have", "been", "characterized", "as", "nonstructured", "basal", "promoters", "that", "carry", "a", "single", "conserved", "ubiquitous", "cyclic", "AMP-responsive", "element", "." ]
[ 0, 1, 2, 2, 2, 2, 2, 2, 0, 0, 0, 0, 1, 2, 2, 0, 0, 0, 0, 0, 1, 2, 2, 2, 0 ]
9743
[ "Although", "the", "activating", "signals", "leading", "to", "Egr-1", "induction", "have", "been", "studied", "extensively", ",", "little", "is", "known", "about", "the", "genes", "that", "are", "placed", "further", "downstream", "within", "this", "activation", "cascade", "and", "that", "are", "transcriptionally", "regulated", "by", "Egr-1", "." ]
[ 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0 ]
18217
[ "Stimulation", "of", "cells", "with", "anti-IgM", "led", "to", "increased", "activity", "of", "a", "nuclear", "kinase", "that", "could", "phosphorylate", "the", "peptide", ",", "and", "this", "activity", "was", "reduced", "by", "10", "microM", "KN-62", "." ]
[ 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
15310
[ "Deletions", "in", "this", "promoter", "indicated", "that", "this", "upregulation", "was", "mediated", "through", "the", "NF-kappa", "B-", "but", "not", "the", "AP-1-binding", "motif", ",", "by", "bona", "fide", "p50/p65", "heterodimers", "." ]
[ 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 9, 10, 0 ]
16130
[ "The", "results", "suggested", "that", "GcR", "in", "hMNL", "are", "down-regulated", "by", "synthetic", "steroids", "given", "in", "vivo", ",", "but", "they", "showed", "very", "mild", "down-regulation", "in", "hypercortisolemic", "patients", "suffering", "from", "Cushing", "'s", "disease", "." ]
[ 0, 0, 0, 0, 9, 0, 7, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
2830
[ "Characterization", "of", "a", "CD43/leukosialin", "-mediated", "pathway", "for", "inducing", "apoptosis", "in", "human", "T-lymphoblastoid", "cells", "." ]
[ 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 7, 8, 8, 0 ]
10368
[ "Granulocyte-macrophage", "colony", "stimulating", "factor", "(", "GM-CSF", ")", "is", "one", "such", "cytokine", ",", "whose", "increased", "expression", "results", "mostly", "from", "increases", "in", "transcription", "." ]
[ 9, 10, 10, 10, 0, 9, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
238
[ "Therefore", ",", "it", "is", "important", "to", "understand", "the", "mechanisms", "which", "control", "the", "expression", "of", "MIP-1", "alpha", "/GOS19", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 9, 0 ]
4065
[ "In", "situ", "hybridizations", "of", "adult", "murine", "tissues", "demonstrate", "Spi-B", "mRNA", "in", "the", "medulla", "of", "the", "thymus", ",", "the", "white", "pulp", "of", "the", "spleen", ",", "and", "the", "germinal", "centers", "of", "lymph", "nodes", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 3, 4, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
2967
[ "We", "have", "found", "that", "the", "basic", "domains", "of", "all", "the", "myogenic", "factors", "remain", "unaltered", "in", "rhabdomyosarcomas", "." ]
[ 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0 ]
13925
[ "Furthermore", ",", "IL-18", "-induced", "activation", "of", "NF-kappaB", "and", "c-Jun", "N-terminal", "kinase", "(", "JNK", ")", "is", "blocked", "in", "MyD88-/-", "Th1-developing", "cells", "." ]
[ 0, 0, 9, 0, 0, 0, 9, 0, 9, 10, 10, 0, 9, 0, 0, 0, 0, 5, 6, 6, 0 ]
3915
[ "Thus", ",", "IL-2", "-induced", "IL-2R", "alpha", "promoter", "activity", "requires", "a", "complex", "upstream", "element", ",", "which", "appears", "to", "contain", "binding", "sites", "for", "both", "positive", "and", "negative", "regulatory", "factors", "." ]
[ 0, 0, 9, 0, 1, 2, 2, 0, 0, 0, 1, 2, 2, 0, 0, 0, 0, 0, 1, 2, 0, 0, 9, 10, 10, 10, 10, 0 ]
16324
[ "The", "proband", "had", "no", "detectable", "DPD", "activity", "." ]
[ 0, 0, 0, 0, 0, 9, 0, 0 ]
2136
[ "In", "vitro", "transcription", "studies", "demonstrate", "that", "astrocyte-derived", "kappa", "B-binding", "factors", "activate", "transcription", "of", "the", "HIV-1", "long", "terminal", "repeat", "and", "that", "this", "activation", "is", "dependent", "on", "the", "kappa", "B", "domain", "." ]
[ 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 0, 0, 0, 0, 1, 2, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 0 ]
133
[ "The", "induction", "of", "cytokine", "expression", "in", "monocytes", "/", "macrophages", "by", "bacterial", "endotoxin", "or", "lipopolysaccharide", "is", "a", "critical", ",", "highly", "regulated", "host", "defence", "response", "." ]
[ 0, 0, 0, 9, 0, 0, 7, 0, 7, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
18054
[ "Accessory", "molecules", "play", "a", "crucial", "role", "in", "the", "development", "of", "the", "T", "cell", "response", "to", "antigenic", "challenge", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
1054
[ "Transient", "chloramphenicol", "acetyltransferase", "assay", "revealed", "that", "the", "region", "containing", "E2F", "binding", "site", "had", "a", "strong", "promoter", "activity", ",", "and", "introduction", "of", "the", "mutation", "at", "the", "E2F", "binding", "site", "resulted", "in", "a", "significant", "loss", "of", "the", "activity", "." ]
[ 0, 9, 10, 0, 0, 0, 0, 0, 0, 1, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
5982
[ "A", "high-affinity", "calcineurin", "-binding", "peptide", "was", "selected", "from", "combinatorial", "peptide", "libraries", "based", "on", "the", "calcineurin", "docking", "motif", "of", "NFAT", "." ]
[ 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 9, 0 ]
14947
[ "We", "have", "previously", "shown", "that", "minimally", "oxidized", "LDL", "(", "MM-LDL", ")", "activated", "endothelial", "cells", "to", "increase", "their", "interaction", "with", "monocytes", "but", "not", "neutrophils", ",", "inducing", "monocyte", "but", "not", "neutrophil", "binding", "and", "synthesis", "of", "monocyte", "chemotactic", "protein-1", "and", "monocyte", "colony-stimulating", "factor", "(", "M-CSF", ")", "." ]
[ 0, 0, 0, 0, 0, 5, 6, 6, 6, 6, 6, 6, 6, 6, 0, 0, 0, 0, 0, 7, 0, 0, 7, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 9, 10, 10, 0, 9, 0, 0 ]
5781
[ "Mutagenesis", "of", "NF", "kappa", "B", "or", "Sp-1", "elements", "within", "the", "LTR", "resulted", "in", "no", "change", "in", "the", "ability", "of", "CD8+", "T", "cell", "supernatants", "to", "inhibit", "Tat-", "or", "mitogen-mediated", "LTR", "transcription", "." ]
[ 0, 0, 1, 2, 2, 2, 2, 2, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
4947
[ "Involvement", "of", "intracellular", "Ca2+", "in", "oxidant-induced", "NF-kappa", "B", "activation", "." ]
[ 0, 0, 0, 0, 0, 0, 9, 10, 0, 0 ]
3385
[ "Now", "that", "these", "proteins", "are", "purified", "and", "cloned", ",", "the", "major", "goals", "will", "be", "to", "understand", "their", "role", "and", "the", "roles", "of", "other", "family", "members", "in", "thymic", "development", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]