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"that",
"of",
"NF-kappa",
"B",
"but",
"is",
"unrelated",
"to",
"this",
"or",
"other",
"Rel",
"proteins",
"by",
"functional",
"and",
"biochemical",
"criteria",
"."
] | [
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10,
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15668 | [
"It",
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"also",
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"distinguished",
"from",
"other",
"previously",
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"lymphocyte-specific",
"DNA-binding",
"proteins",
"."
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0,
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15669 | [
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"Bcl-3",
"is",
"an",
"antagonist",
"of",
"p50/NF-kappa",
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"inhibition",
"."
] | [
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0,
9,
10,
0,
0,
0,
0,
9,
10,
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0,
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15670 | [
"The",
"candidate",
"oncogene",
"bcl-3",
"was",
"discovered",
"as",
"a",
"translocation",
"into",
"the",
"immunoglobulin",
"alpha-locus",
"in",
"some",
"cases",
"of",
"B-cell",
"chronic",
"lymphocytic",
"leukaemias",
"."
] | [
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0,
1,
2,
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1,
2,
0,
0,
0,
0,
7,
0,
0,
0,
0
] |
15671 | [
"The",
"protein",
"Bcl-3",
"contains",
"seven",
"so-called",
"ankyrin",
"repeats",
"."
] | [
0,
9,
10,
0,
0,
0,
9,
0,
0
] |
15672 | [
"Similar",
"repeat",
"motifs",
"are",
"found",
"in",
"a",
"number",
"of",
"diverse",
"regulatory",
"proteins",
"but",
"the",
"motifs",
"of",
"Bcl-3",
"are",
"most",
"closely",
"related",
"to",
"those",
"found",
"in",
"I",
"kappa",
"B",
"proteins",
"in",
"which",
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"thought",
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"directly",
"involved",
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"."
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0,
0,
0,
0,
0,
0,
9,
10,
0,
0
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15673 | [
"No",
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"function",
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"described",
"for",
"Bcl-3",
",",
"but",
"it",
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"noted",
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"."
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0,
9,
10,
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9,
10,
0,
0,
0
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15674 | [
"Here",
"we",
"demonstrate",
"that",
"Bcl-3",
"can",
"aid",
"kappa",
"B",
"site",
"-dependent",
"transcription",
"in",
"vivo",
"by",
"counteracting",
"the",
"inhibitory",
"effects",
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"homodimers",
"."
] | [
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2,
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0,
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0,
0,
0,
0,
0,
9,
10,
10,
0
] |
15675 | [
"Bcl-3",
"may",
"therefore",
"aid",
"activation",
"of",
"select",
"NF-kappa",
"B-regulated",
"genes",
",",
"including",
"those",
"of",
"the",
"human",
"immunodeficiency",
"virus",
"."
] | [
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0,
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0,
0,
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1,
2,
2,
0,
0,
0,
0,
0,
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0,
0,
0
] |
15676 | [
"[",
"Mechanism",
"of",
"action",
"of",
"steroid",
"hormones.",
"I.",
"Estrogens",
"]"
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
15677 | [
"The",
"steroid",
"hormone",
"are",
"very",
"versatile",
"molecules",
":",
"although",
"they",
"are",
"related",
"among",
"them",
"by",
"their",
"chemical",
"structure",
",",
"they",
"have",
"very",
"diverse",
"functions",
"and",
"including",
"antagonic",
"."
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0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
15678 | [
"Their",
"action",
"mechanism",
"is",
"not",
"completely",
"cleared",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0
] |
15679 | [
"The",
"estrogens",
"participate",
"in",
"the",
"regulation",
"of",
"practically",
"all",
"the",
"reproductive",
"and",
"sexual",
"events",
"of",
"the",
"female",
",",
"although",
"the",
"intracellular",
"actions",
"by",
"which",
"they",
"take",
"place",
"are",
"not",
"well",
"known",
"and",
"the",
"proposed",
"models",
"do",
"not",
"adequately",
"satisfy",
"the",
"questions",
"."
] | [
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0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
15680 | [
"Currently",
"it",
"is",
"accepted",
"the",
"existence",
"of",
"a",
"cytoplasmic",
"and/or",
"nuclear",
"receptor",
",",
"without",
"explaining",
"satisfactorily",
"how",
"the",
"hormones",
"come",
"to",
"the",
"nucleus",
"."
] | [
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0,
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0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
15681 | [
"The",
"endocrine",
"events",
"that",
"are",
"rapidly",
"expressed",
"(",
"seconds",
")",
"are",
"due",
"to",
"a",
"possible",
"interaction",
"with",
"cellular",
"membrane",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
15682 | [
"The",
"purpose",
"of",
"this",
"review",
"is",
"to",
"analyze",
"and",
"concilliate",
"the",
"reported",
"data",
"on",
"the",
"mechanism",
"of",
"action",
"of",
"estrogens",
"."
] | [
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0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
15683 | [
"Reduced",
"susceptibility",
"to",
"HIV-1",
"infection",
"of",
"ethyl-methanesulfonate-treated",
"CEM",
"subclones",
"correlates",
"with",
"a",
"blockade",
"in",
"their",
"protein",
"kinase",
"C",
"signaling",
"pathway",
"."
] | [
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6,
0,
0,
0,
0,
0,
0,
9,
10,
10,
0,
0,
0
] |
15684 | [
"We",
"have",
"described",
"the",
"isolation",
"of",
"chemically",
"induced",
"CEM",
"subclones",
"that",
"express",
"CD4",
"receptors",
"and",
"bind",
"soluble",
"gp120",
",",
"yet",
"show",
"a",
"markedly",
"reduced",
"susceptibility",
"to",
"infection",
"with",
"HIV-1",
"."
] | [
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0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
15685 | [
"Two",
"subclones",
"were",
"found",
"to",
"have",
"an",
"abnormal",
"response",
"to",
"the",
"protein",
"kinase",
"C",
"(",
"PKC",
")",
"activator",
"PMA",
"."
] | [
0,
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0,
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0,
0,
0,
0,
0,
0,
0,
9,
10,
10,
0,
9,
0,
0,
0,
0
] |
15686 | [
"PMA",
"treatment",
"induced",
"CD3",
"and",
"CD25",
"(",
"IL-2R",
")",
"receptors",
"on",
"the",
"parental",
"line",
"and",
"on",
"other",
"ethyl-methanesulfonate-derived",
"subclones",
",",
"but",
"not",
"on",
"these",
"two",
"mutants",
"."
] | [
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0,
0,
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0,
9,
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10,
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10,
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0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
15687 | [
"Direct",
"assays",
"of",
"PKC",
"activity",
"were",
"conducted",
"."
] | [
0,
0,
0,
9,
0,
0,
0,
0
] |
15688 | [
"Total",
"cellular",
"PKC",
"enzymatic",
"activity",
"was",
"found",
"to",
"be",
"normal",
"in",
"these",
"subclones",
"."
] | [
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
15689 | [
"PMA-induced",
"CD4",
"down-modulation",
"occurred",
"normally",
"."
] | [
0,
9,
0,
0,
0,
0
] |
15690 | [
"In",
"addition",
",",
"activation",
"of",
"c-raf",
"kinase",
"was",
"normal",
"."
] | [
0,
0,
0,
0,
0,
9,
10,
0,
0,
0
] |
15691 | [
"Since",
"HIV-1",
"long",
"terminal",
"repeat",
"contains",
"two",
"functional",
"nuclear",
"factor",
"kB",
"(",
"NF-kB",
")",
"regulatory",
"elements",
",",
"we",
"studied",
"the",
"ability",
"of",
"PMA",
"to",
"induce",
"NF-kB",
"binding",
"activity",
"by",
"different",
"assays",
"."
] | [
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1,
2,
2,
2,
0,
0,
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1,
2,
2,
2,
2,
2,
2,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0
] |
15692 | [
"Chloramphenicol",
"acetyl",
"transferase",
"(",
"CAT",
")",
"assays",
"using",
"the",
"HIV-1",
"(",
"-139",
")",
"long",
"terminal",
"repeat-CAT",
"construct",
"showed",
"no",
"PMA",
"induction",
"of",
"CAT",
"activity",
"in",
"these",
"subclones",
"(",
"unlike",
"the",
"parental",
"line",
"and",
"other",
"subclones",
")",
"."
] | [
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10,
10,
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1,
2,
2,
2,
2,
2,
2,
2,
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0,
0,
0,
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0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
15693 | [
"Okadaic",
"acid",
",",
"an",
"inhibitor",
"of",
"phosphatases",
"1",
"and",
"2A",
",",
"did",
"not",
"overcome",
"the",
"defect",
"in",
"these",
"subclones",
"."
] | [
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0,
9,
10,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
15694 | [
"Gel",
"retardation",
"assays",
",",
"using",
"a",
"32P-probe",
"containing",
"the",
"HIV-1",
"NF-kB",
"probe",
"and",
"nuclear",
"extracts",
"from",
"PMA-treated",
"cells",
",",
"showed",
"significantly",
"reduced",
"induction",
"of",
"nuclear",
"NF-kB",
"binding",
"proteins",
"in",
"these",
"two",
"subclones",
"compared",
"with",
"wild",
"type",
"CEM",
"and",
"a",
"control",
"subclone",
"."
] | [
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0,
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0,
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1,
2,
2,
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0,
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0,
0,
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0,
0,
0,
0,
0,
0,
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9,
10,
10,
0,
0,
0,
0,
0,
0,
0,
0,
5,
0,
0,
0,
0,
0
] |
15695 | [
"Deoxycholate",
"treatment",
"of",
"cytoplasmic",
"extracts",
"from",
"these",
"subclones",
"released",
"much",
"reduced",
"NF-kB",
"binding",
"proteins",
"from",
"their",
"cytoplasmic",
"pools",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
10,
0,
0,
0,
0,
0
] |
15696 | [
"Thus",
",",
"reduced",
"levels",
"of",
"PKC",
"-induced",
"nuclear",
"NF-kB",
"activity",
"in",
"two",
"T",
"cell",
"subclones",
"did",
"not",
"affect",
"their",
"normal",
"cell",
"growth",
",",
"but",
"correlated",
"with",
"a",
"pronounced",
"reduction",
"in",
"their",
"susceptibility",
"to",
"HIV-1",
"infection",
"."
] | [
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0,
0,
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0,
9,
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0,
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6,
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0,
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0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
15697 | [
"Nuclear",
"factor",
"of",
"activated",
"T",
"cells",
"contains",
"Fos",
"and",
"Jun",
"."
] | [
9,
10,
10,
10,
10,
10,
0,
9,
0,
9,
0
] |
15698 | [
"The",
"nuclear",
"factor",
"NF-AT",
"(",
"ref.",
"1",
")",
"is",
"induced",
"in",
"T",
"cells",
"stimulated",
"through",
"the",
"T-cell",
"receptor/CD3",
"complex",
",",
"and",
"is",
"required",
"for",
"interleukin-2",
"(",
"IL-2",
")",
"gene",
"induction",
"."
] | [
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9,
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8,
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9,
10,
10,
0,
0,
0,
0,
0,
1,
2,
2,
2,
2,
0,
0
] |
15699 | [
"Although",
"NF-AT",
"has",
"not",
"been",
"cloned",
"or",
"purified",
",",
"there",
"is",
"evidence",
"that",
"it",
"is",
"a",
"major",
"target",
"for",
"immunosuppression",
"by",
"cyclosporin",
"A",
"(",
"CsA",
")",
"and",
"FK506",
"(",
"refs",
"2-7",
")",
"."
] | [
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0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
15700 | [
"NF-AT",
"induction",
"may",
"require",
"two",
"activation-dependent",
"events",
":",
"the",
"CsA-sensitive",
"translocation",
"of",
"a",
"pre-existing",
"component",
"and",
"the",
"CsA-resistant",
"synthesis",
"of",
"a",
"nuclear",
"component",
"."
] | [
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0,
0,
0,
0,
0,
0,
0
] |
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