topic
stringlengths 245
1.29k
| doc
stringlengths 52
16.9k
| label
stringclasses 3
values |
|---|---|---|
A 25-year-old woman presents to the clinic complaining of prolonged fatigue. She denies difficulty sleeping and sleeps an average of 8 hours a night. She also notes hair loss, a change in her voice and weight gain during the previous 6 months. She complains of cold intolerance. On examination she has a prominent, soft, uniform anterior cervical mass at the midline. | eligible ages (years): 18.0-999.0, Thyroid Cancer Differentiated thyroid cancer treated by thyroidectomy and at least 1 ablation with 131-I > 5 months ago TSH < 4 imU/L Pregnancy Known metastasis | 1 |
A 25-year-old woman presents to the clinic complaining of prolonged fatigue. She denies difficulty sleeping and sleeps an average of 8 hours a night. She also notes hair loss, a change in her voice and weight gain during the previous 6 months. She complains of cold intolerance. On examination she has a prominent, soft, uniform anterior cervical mass at the midline. | eligible ages (years): 40.0-75.0, Hypothyroidism Thyroid Diseases Endocrine System Diseases 75 years old Diagnosis of overt or subclinical hypothyroidism in two occasions with a minimum interval period of three months Pregnant or lactating women Severe hepatic or renal dysfunction Psychiatric disabilities, acute cardiovascular and cerebrovascular diseases, chronic respiratory diseases, familiar hypercholesterolemia, malignancy, cholelithiasis, pancreatitis, bowel diseases and other disorders influencing lipid and bile acid metabolism Taking lipid-lowering agents and other drugs influencing thyroid function, lipid and bile acid metabolism Obviously poor compliance | 0 |
A 25-year-old woman presents to the clinic complaining of prolonged fatigue. She denies difficulty sleeping and sleeps an average of 8 hours a night. She also notes hair loss, a change in her voice and weight gain during the previous 6 months. She complains of cold intolerance. On examination she has a prominent, soft, uniform anterior cervical mass at the midline. | eligible ages (years): 60.0-999.0, Biomarkers of Stress in Emergency Physicians emergency physician endocrine disease, pregnancy, recent extraprofessional deleterious life event (such as death of a near relative, divorce), any current illness, drugs used to modulate inflammatory diseases (corticosteroids, anti-inflammatory drugs, immunomodulatory drugs), or any drugs with a chronotropic effect taken over the previous six months (beta blockers, diltiazem, verapamil, anxiolytics or antidepressants) | 0 |
A 25-year-old woman presents to the clinic complaining of prolonged fatigue. She denies difficulty sleeping and sleeps an average of 8 hours a night. She also notes hair loss, a change in her voice and weight gain during the previous 6 months. She complains of cold intolerance. On examination she has a prominent, soft, uniform anterior cervical mass at the midline. | eligible ages (years): 18.0-999.0, Breast Cancer Alopecia New diagnosis of breast cancer stage 1-2 Planning to undergo neoadjuvant or adjuvant chemotherapy with curative intent Chemotherapy must be planned for at least 4 cycles of full-dose anthracycline or taxane based chemotherapy regimen Defined as one of the following regimens Adriamycin 60mg/m2 with cyclophosphamide 600mg/m2 Epirubicin 90-100mg/m2 with cyclophosphamide 600mg/m2 Paclitaxel 80mg-90/m2 weekly (every three weeks constitute a cycle), or 175 mg/m2 every 2-3 weeks as a single agent Docetaxel 100mg/m2 as a single agent Docetaxel 75mg/m2 with cyclophosphamide 600mg/m2 Docetaxel 75mg/m2 with carboplatin AUC of 6 and trastuzumab at standard doses Stage 3 or 4 breast cancer or any other concurrent malignancy including hematological malignancies (i.e. leukemia or lymphoma) Baseline alopecia (defined CTCAE v4.0 grade > 0, see appendix B for CTCAE v4.0 scale) Subjects with cold agglutinin disease or cold urticaria Subjects who are scheduled for bone marrow ablation chemotherapy Subjects receiving chemotherapy with concurrent anthracycline and taxane (AT or TAC) Male gender | 0 |
A 25-year-old woman presents to the clinic complaining of prolonged fatigue. She denies difficulty sleeping and sleeps an average of 8 hours a night. She also notes hair loss, a change in her voice and weight gain during the previous 6 months. She complains of cold intolerance. On examination she has a prominent, soft, uniform anterior cervical mass at the midline. | eligible ages (years): 18.0-999.0, Cancer have stage III or IV cancer diagnosis able to understand English have a Karnofsky Performance Status (KPS) score of 60% (able to care for most of the personal needs) have fatigue and/or two other target symptoms have been cleared by their provider to engage low to moderate intensity physical activities are hospitalized have lesion or metastasis of bone have a cardiac pacemaker have a history of seizure or loss of consciousness have been using a Wii Fit diagnosed cognitive impairment | 0 |
A 25-year-old woman presents to the clinic complaining of prolonged fatigue. She denies difficulty sleeping and sleeps an average of 8 hours a night. She also notes hair loss, a change in her voice and weight gain during the previous 6 months. She complains of cold intolerance. On examination she has a prominent, soft, uniform anterior cervical mass at the midline. | eligible ages (years): 25.0-65.0, Obesity Prevention of Weight Gain. Men and women between 25 and 65 years of age Overweight or Class I or Class II BMI Walk without assistance Commit to a schedule of assessment visits Physical impairment which would make the intervention very difficult, or unsafe according to the patient's physician including history of myocardial infarction, stroke, coronary bypass surgery or angioplasty in the last 6 months; peripheral artery disease, unstable angina or ischemia Enrolled within past year in a formal weight loss program Reported losing greater than 5% of current body weight in the previous 6 months Smoking Plans to move from the area Participating in another research study Clinically judged to be unsuitable for participation or adherence as determined by the participants physician Inability or unwillingness to provide informed consent | 0 |
A 25-year-old woman presents to the clinic complaining of prolonged fatigue. She denies difficulty sleeping and sleeps an average of 8 hours a night. She also notes hair loss, a change in her voice and weight gain during the previous 6 months. She complains of cold intolerance. On examination she has a prominent, soft, uniform anterior cervical mass at the midline. | eligible ages (years): 18.0-60.0, Asthma years of age or older Known Asthma The exacerbation is defined as moderate or severe Not currently enrolled as an active participant in another clinical trial of a medical therapy or device The patient or first degree family relative (in cases where the patient is intubated) has authorized his/her consent to participate in this trial. The patient will be asked to give his consent only after initial bronchodilator therapy years of age or older Known thyroid disorders Subject where thyrotoxicosis is suspected Known heart disease Heart rate > 140 | 0 |
A 25-year-old woman presents to the clinic complaining of prolonged fatigue. She denies difficulty sleeping and sleeps an average of 8 hours a night. She also notes hair loss, a change in her voice and weight gain during the previous 6 months. She complains of cold intolerance. On examination she has a prominent, soft, uniform anterior cervical mass at the midline. | eligible ages (years): 18.0-45.0, Hypothyroidism Consecutive pregnant women with L-T4 treated hypothyroidism followed at the outpatient clinic at the Endocrinology Unit, Herlev Hospital, Denmark during 2012 | 0 |
A 25-year-old woman presents to the clinic complaining of prolonged fatigue. She denies difficulty sleeping and sleeps an average of 8 hours a night. She also notes hair loss, a change in her voice and weight gain during the previous 6 months. She complains of cold intolerance. On examination she has a prominent, soft, uniform anterior cervical mass at the midline. | eligible ages (years): 18.0-35.0, Hashimoto's Thyroiditis Newly diagnosed (within 1 year) Hashimoto's thyroiditis by positive serum anti-TPO antibody or anti-thyroglobulin antibody Euthyroid state by serum free T4 and TSH level within normal limit Pregnant, planning pregnant within 1 year, or lactating women Renal insufficiency, abnormal liver function test Hematologic diseases: anemia, agranulocytosis, thrombocytopenia G6PD deficiency, porphyria cutaneous tarda Allergy to 4-aminoquinoline compounds Known retinopathy or visual field defect disorders Already receive immunosuppression therapy | 0 |
A 25-year-old woman presents to the clinic complaining of prolonged fatigue. She denies difficulty sleeping and sleeps an average of 8 hours a night. She also notes hair loss, a change in her voice and weight gain during the previous 6 months. She complains of cold intolerance. On examination she has a prominent, soft, uniform anterior cervical mass at the midline. | eligible ages (years): 18.0-999.0, Hypothyroidism Subclinical Hypothyroidism Hyperthyroidism Subclinical Hyperthyroidism Graves Disease Hashimoto's Thyroiditis Iodine Deficiency Genetic Susceptibility Aged equal or more than 18 years old at the time of sampling Malaysian citizen Respondents who did not give consent | 0 |
A 25-year-old woman presents to the clinic complaining of prolonged fatigue. She denies difficulty sleeping and sleeps an average of 8 hours a night. She also notes hair loss, a change in her voice and weight gain during the previous 6 months. She complains of cold intolerance. On examination she has a prominent, soft, uniform anterior cervical mass at the midline. | eligible ages (years): 21.0-100.0, Health Behavior adults age 21 and over referred by primary care physician for health coaching have telephone for follow-up English speaking pregnant or trying to become pregnant | 0 |
A 25-year-old woman presents to the clinic complaining of prolonged fatigue. She denies difficulty sleeping and sleeps an average of 8 hours a night. She also notes hair loss, a change in her voice and weight gain during the previous 6 months. She complains of cold intolerance. On examination she has a prominent, soft, uniform anterior cervical mass at the midline. | eligible ages (years): 21.0-80.0, Insomnia Primary Insomnia Chronic Insomnia to 80 years of age Insomnia sufferers enrolled, will meet Research Diagnostic for insomnia disorder score > 14 on the Insomnia Severity Index report insomnia for > 3 months have sleep difficulties > 3 nights per week score < 3 on the Epworth Sleepiness Scale (ESS) score > 40 on the Hyperarousal Scale and report an inability to nap in the daytime The normal sleepers enrolled will report general satisfaction with sleep and no sleep/wake complaints, score < 10 on the ESS, score < 35 on the Hyperarousal Scale, and deny a practice of routine daytime napping sleep-disruptive medical condition (e.g., rheumatoid arthritis) current major psychiatric (Axis I) condition on the basis of a Structured Clinical Interview for Psychiatric Disorders (SCID) sedative hypnotic dependence and unwillingness/inability to abstain from these medications while in the study use of anxiolytics, antidepressants, or any other psychotropic medication an apnea/hypopnea index (AHI) > 5 or a periodic limb movement-related arousal index > 5 during on screening PSG that includes a full sleep montage to allow for detection/diagnosis of sleep-disordered breathing and PLMD female participants who have tested positive on urine pregnancy tests or planing on becoming pregnant during the study Additionally, self-described NS who meet for any sleep disorder and those insomnia sufferers who meet for a comorbid sleep disorder in addition to insomnia disorder will also be excluded | 0 |
A 25-year-old woman presents to the clinic complaining of prolonged fatigue. She denies difficulty sleeping and sleeps an average of 8 hours a night. She also notes hair loss, a change in her voice and weight gain during the previous 6 months. She complains of cold intolerance. On examination she has a prominent, soft, uniform anterior cervical mass at the midline. | eligible ages (years): 19.0-999.0, Post Radiation/Chemotherapy Alopecia Presents With Hair Thinning. Post-burn Alopecia Presents With Hair Thinning. Cicatricial Alopecia Presents With Hair Thinning. Androgenetic Alopecia Presents With Hair Thinning Alopecia Due to Traumatic Injuries Presents With Hair Thinning. Alopecia Due to Skin Disease Presents With Hair Thinning. Subject is ≥ 19 years old Subject has hair thinning of any etiology and has chosen to undergo hair extensions treatment Subject has mental capacity to understand study guidelines and requirements (to maintain scalp hygiene, delicate combing, etc.) Subject has been evaluated by the investigator to have a scalp condition in the planned area of implantation that is acceptable for entering the study and currently is NOT suffering from skin problems at planned implantation site around it Subject has Good general health Woman of child bearing potential must have a negative pregnancy test Subject willing to sign a written informed consent form (ICF) and the post implantation maintenance protocol Previous other synthetic hair implants or hair transplantation in the past six months. Subjects with previous Hairstetics' implants implanted less than 6 month prior to screening are allowed, if the implants are located in a different location on the scalp Currently suffering from skin problems at planned implantation site or around it that might affect the procedure and/or success as clinically evaluated by the investigator Currently receiving or have within the past 3 months received radiation and/or chemotherapy Currently using steroid product with Immunosuppressive treatment Impaired coagulation Serious illness that may affect subject compliance to protocol Subject is using illegal drugs Participating in other clinical study Known allergy or hypersensitivity to Nitinol or Nickel or Titanium | 0 |
A 25-year-old woman presents to the clinic complaining of prolonged fatigue. She denies difficulty sleeping and sleeps an average of 8 hours a night. She also notes hair loss, a change in her voice and weight gain during the previous 6 months. She complains of cold intolerance. On examination she has a prominent, soft, uniform anterior cervical mass at the midline. | eligible ages (years): 18.0-35.0, Sleep Pregnancy Stillbirth Infant, Low Birth Weight Infant, Small for Gestational Age Infant, Very Low Birth Weight Fetal Growth Retardation Fetal Hypoxia ≥18 years old low-risk singleton pregnancy entering the last trimester of pregnancy (in range 26-30 weeks of gestation) residing in the Greater Accra Metropolitan Area or area served by the Korle Bu Teaching Hospital fluent in either English, Twi, or Ga BMI ≥ 35 at booking (first antenatal appointment for current pregnancy) pregnancy complicated by obstetric complications (hypertension [pre-eclampsia, gestational hypertension, chronic hypertension], diabetes [gestational or not], or intra-uterine growth restriction [<10th %ile for growth]) sleep complicated by medical conditions (known to get <4 hours of sleep per night due to insomnia, or musculoskeletal disorder that prevents sleeping on a certain side [e.g., arthritic shoulder]) multiple pregnancy known fetal abnormality maternal age >35 | 0 |
A 25-year-old woman presents to the clinic complaining of prolonged fatigue. She denies difficulty sleeping and sleeps an average of 8 hours a night. She also notes hair loss, a change in her voice and weight gain during the previous 6 months. She complains of cold intolerance. On examination she has a prominent, soft, uniform anterior cervical mass at the midline. | eligible ages (years): 18.0-45.0, Diabetes Weight Gain Weight Loss Cardiovascular Disease Obesity Participants will be men of European (self-report of both parents of white European origin) or South Asian (self-report of both parents of Indian, Pakistani, Bangladeshi or Sri Lankan origin) with BMI <25 kg.m-2, who have been weight stable (± 2 kg) for >6 months will diabetes (physician diagnosed or HbA1c ≥6.5% on screening), history of cardiovascular disease, regular participation in vigorous physical activity, current smoking, taking drugs or supplements thought to affect carbohydrate or lipid metabolism, or other significant illness that would prevent full participation in the study | 0 |
A 25-year-old woman presents to the clinic complaining of prolonged fatigue. She denies difficulty sleeping and sleeps an average of 8 hours a night. She also notes hair loss, a change in her voice and weight gain during the previous 6 months. She complains of cold intolerance. On examination she has a prominent, soft, uniform anterior cervical mass at the midline. | eligible ages (years): 4.0-18.0, Hashimoto Thyroiditis Graves Disease For HT A positive titers of antithyroid peroxidase (anti-TPO) or antithyroglobulin (anti-Tg) antibodies and at least one of Abnormal thyroid function that requires substitution treatment with L-thyroxine (TSH > 5 μIU/ml and decreased or normal levels of fT4 or fT3) Increased volume of thyroid gland (goiter) Morphological changes on ultrasound of the thyroid gland For GD A positive titers of thyroid stimulating antibodies (anti-TSI) and Decreased TSH levels and increased levels of fT4 or fT3 For Controls Otherwise healthy children and adolescents, age Not Caucasian origin or affinity among participants Age of diagnosis above 18 years Disease duration below 3 months | 1 |
A 25-year-old woman presents to the clinic complaining of prolonged fatigue. She denies difficulty sleeping and sleeps an average of 8 hours a night. She also notes hair loss, a change in her voice and weight gain during the previous 6 months. She complains of cold intolerance. On examination she has a prominent, soft, uniform anterior cervical mass at the midline. | eligible ages (years): 18.0-80.0, Hypothyroidism Neoplasms Postoperative Complications Biopsy proven head and neck cancer, as defined by AJCC staging system Treated with surgery in Edmonton, Alberta Treated with curative intent Diagnosis of sub-clinical hypothyroidism after head and neck surgery (TSH 4-10mIU/L, and free T4 10-24pmol/L) Head and neck cancer of the thyroid gland, or other subsite involving the thyroid gland Underwent previous treatment for a different head and neck cancer History of radiation therapy and or chemotherapy to the head and neck History of thyroid disease as follows Hypothyroidism Hyperthyroidism Autoimmune thyroid disease including Grave's disease and Hashimoto's thyroiditis History of thyroiditis History of diabetes mellitus History of long term steroid usage | 0 |
A 25-year-old woman presents to the clinic complaining of prolonged fatigue. She denies difficulty sleeping and sleeps an average of 8 hours a night. She also notes hair loss, a change in her voice and weight gain during the previous 6 months. She complains of cold intolerance. On examination she has a prominent, soft, uniform anterior cervical mass at the midline. | eligible ages (years): 8.0-15.0, Type 1 Diabetes Stress Informed consent signed by a parent/legal guardian and informed assent signed by the study participant prior study entry Diagnosed with Type 1 DM/Hashimoto thyroiditis prior to signature of Patient Informed Consent (PIC) (for the T1D group) Age between 8-15 years old (inclusive) at signature of PIC Treated by the investigator's centre prior signature of PIC (For the T1D and HT group) Willing to undergo all study procedures Any documented concomitant chronic disease known to affect diabetes control (e.g. altered renal function, active cancer undergoing treatment, Crohn's disease, ulcerative colitis, Mb Addison disease) Any other medical, social or psychological condition that, in the investigator's opinion, makes the patient unable to comply with the study protocol (e.g. intellectual disability) | 0 |
A 25-year-old woman presents to the clinic complaining of prolonged fatigue. She denies difficulty sleeping and sleeps an average of 8 hours a night. She also notes hair loss, a change in her voice and weight gain during the previous 6 months. She complains of cold intolerance. On examination she has a prominent, soft, uniform anterior cervical mass at the midline. | eligible ages (years): 20.0-80.0, Head and Neck Neoplasms Patients aged 20 to 80 years scheduled to receive neck dissection due to head and neck cancer history of coagulation disorders prior radiation to the neck prior neck dissection declined to participate | 0 |
A 25-year-old woman presents to the clinic complaining of prolonged fatigue. She denies difficulty sleeping and sleeps an average of 8 hours a night. She also notes hair loss, a change in her voice and weight gain during the previous 6 months. She complains of cold intolerance. On examination she has a prominent, soft, uniform anterior cervical mass at the midline. | eligible ages (years): 2.0-18.0, Pediatric Sleep Apnea children (younger than 18 years old and older than 2 years old) with symptoms of snoring and then were confirmed to having obstructive sleep apnea/hypopnea syndrome by a comprehensive polysomnography patients with substance abuse problems or the long-term usage of medications known to affect sleep, craniofacial abnormalities or neuromuscular disorders, Down syndrome, cerebral palsy, mucopolysaccharidoses, Prader-Willi syndrome, history of psychosis, central sleep apnea syndrome, or previous airway surgery including tonsillectomy and/or adenoidectomy were excluded from the study | 0 |
A 30-year-old generally healthy woman presents with shortness of breath that had started 2 hours before admission. She has had no health problems in the past besides 2 natural abortions. She had given birth to a healthy child 3 weeks before. On examination, she is apprehensive, tachypneic and tachycardic, her blood pressure is 110/70 and her oxygen saturation 92%. Otherwise, physical examination is unremarkable. Her chest x-ray and CBC are normal. | eligible ages (years): 18.0-999.0, Lung Neoplasms Breast Neoplasms Diagnosis of local or metastatic breast or lung cancer Shortness of breath with onset after cancer diagnosis Life expectancy of at least 4 weeks Prior acupuncture Other conditions suspected of causing shortness of breath, such as congestive heart failure, sarcoid disease, pneumonia, or obesity No chest wall deformity Neuromuscular disorders Pulmonary vascular disease Anemia Uncontrolled pain or infection Heart valve dysfunction | 0 |
A 30-year-old generally healthy woman presents with shortness of breath that had started 2 hours before admission. She has had no health problems in the past besides 2 natural abortions. She had given birth to a healthy child 3 weeks before. On examination, she is apprehensive, tachypneic and tachycardic, her blood pressure is 110/70 and her oxygen saturation 92%. Otherwise, physical examination is unremarkable. Her chest x-ray and CBC are normal. | eligible ages (years): 40.0-999.0, Heart Failure, Congestive We plan to all patients presenting to the ED with shortness of breath that are over 40 years old and present with an emergency department triage category of 3 or higher Patients presenting with a traumatic cause of dyspnea, patients with severe renal disease (serum creatinine level of more than 250 micro mmol/L, patients with cardiogenic shock, and patients who have an early transfer to another hospital (within 24 hrs) will be excluded | 2 |
A 30-year-old generally healthy woman presents with shortness of breath that had started 2 hours before admission. She has had no health problems in the past besides 2 natural abortions. She had given birth to a healthy child 3 weeks before. On examination, she is apprehensive, tachypneic and tachycardic, her blood pressure is 110/70 and her oxygen saturation 92%. Otherwise, physical examination is unremarkable. Her chest x-ray and CBC are normal. | eligible ages (years): 18.0-999.0, Pulmonary Embolism Right Heart Strain Referred from clinical departments at Odense University Hospital Referred to the Departments of Nuclear Medicine or Radiology for diagnostic evaluation of suspected pulmonary embolism Referred for lung scintigraphy, spiral computer tomography, or pulmonary angiography Age below 18 Contrast allergy Pregnancy S-Creatinine above 200 micromol/L Metformin treatment Fibrinolytic or surgical therapy between examinations No informed consent Withdrawn consent Failed logistics (more than 24 hours between examinations) No conclusive pulmonary angiography | 1 |
A 30-year-old generally healthy woman presents with shortness of breath that had started 2 hours before admission. She has had no health problems in the past besides 2 natural abortions. She had given birth to a healthy child 3 weeks before. On examination, she is apprehensive, tachypneic and tachycardic, her blood pressure is 110/70 and her oxygen saturation 92%. Otherwise, physical examination is unremarkable. Her chest x-ray and CBC are normal. | eligible ages (years): 16.0-999.0, Adult Respiratory Distress Syndrome Pulmonary Hypertension After obtaining informed consent the following patients will be included All patients admitted to the ICU with pulmonary hypertension (mean PA > 35 mmHg) All patients in ICU with post operative pulmonary HTN (mean PA > 35 mm Hg) All patients with ARDS (PaO2/FiO2 < 200 arterial hypoxemia, bilateral infiltrates on Chest X-ray infiltrates on CXR and a wedge < 20 mm Hg on swan ganz parameters) or signs of heart failure Patients to be excluded will be those with Pulmonary embolus Cor pulmonale Ejection fraction of < 30%, wedge > 20 mm Hg Non-intubated patients Pediatric patients (< 16 yrs of age) | 0 |
A 30-year-old generally healthy woman presents with shortness of breath that had started 2 hours before admission. She has had no health problems in the past besides 2 natural abortions. She had given birth to a healthy child 3 weeks before. On examination, she is apprehensive, tachypneic and tachycardic, her blood pressure is 110/70 and her oxygen saturation 92%. Otherwise, physical examination is unremarkable. Her chest x-ray and CBC are normal. | eligible ages (years): 18.0-999.0, Ischemic Stroke Angiographically confirmed large vessel ischemic stroke (occlusion may the following: internal carotid artery (ICA), M1/M2, vertebral, or basilar arteries) Intervention is able to be performed within 8 hours of symptom onset Patients > 18 years of age NIHSS score 8+ Failed IV t-PA treatment or contraindicated for IV t-PA International Normalized Ratio (INR) > 3.0 Platelet count < 30,000 Heparin use in previous 24 hours with PTT > 2X normal Baseline bloog glucose < 50 mg/dL Baseline computed tomography (CT) showing mass effect with midline shift Severe sustained hypertension (SBP > 185 or DBP > 110) that cannot be controlled with medication Patient is pregnant, has anticipated life expectancy < 3 months, or has severe allergy to contrast medium Arterial stenosis > 50% proximal to embolus Excessive arterial tortuosity that precludes the study device from reaching the target area | 0 |
A 30-year-old generally healthy woman presents with shortness of breath that had started 2 hours before admission. She has had no health problems in the past besides 2 natural abortions. She had given birth to a healthy child 3 weeks before. On examination, she is apprehensive, tachypneic and tachycardic, her blood pressure is 110/70 and her oxygen saturation 92%. Otherwise, physical examination is unremarkable. Her chest x-ray and CBC are normal. | eligible ages (years): 18.0-45.0, Uterine Leiomyoma Participants in the Right From The Start Study must be 18 years old or older, pregnant, enrolled by 10 weeks of gestation, planning to carry pregnancy to term, no plans to move before delivery, and English speaking. Those who are found to have fibroids at either their 7-week, or 22-week ultrasound examination are eligible for this further postpregnancy study A small substudy of 30 women having MRIs to evaluate the sensitivity of the ultrasound imaging will only participants with a single fibroid found at the early pregnancy ultrasound FOR MRI for the MRI are weight greater than 250 pounds, currently pregnant, metal of specific types in the body (an artificial hip, a clip for brain aneurysm, a medical implant in the ear, metal fragment in the eye, or a pacemaker), history of claustrophobia, previous severe reaction to MRI contrast, and chronic kidney disease. A severe reaction would consist of bronchospasm (shortness of breath/difficulty breathing) or shock (sudden loss of blood pressure). Risk is less than 1/100,000 with Gd based contrast material. Any potential subject with a history of kidney disease will be excluded from the study | 0 |
A 30-year-old generally healthy woman presents with shortness of breath that had started 2 hours before admission. She has had no health problems in the past besides 2 natural abortions. She had given birth to a healthy child 3 weeks before. On examination, she is apprehensive, tachypneic and tachycardic, her blood pressure is 110/70 and her oxygen saturation 92%. Otherwise, physical examination is unremarkable. Her chest x-ray and CBC are normal. | eligible ages (years): 12.0-24.0, Substance Abuse Native American pregnant teens or young women ages 12-22 years old at the time of conception Women ages 20-22 years at the time of conception must be pregnant for the first time Partners of pregnant teens must be between the ages of 12-24 Pregnant <28 weeks gestation and able to meet the requirements for completing the program in a timely way An enrolled tribal member Reside in the Reservation Service Unit Catchment Area and within 60 mile of the Indian Health Service Unit Headquarters Severe mental illness schizophrenia, bipolar disorder, incapacitating depression, or Substance abuse/dependence in need of intensive and specific treatment Active legal problems – subjects will not be enrolled if they are incarcerated or if program participation has been made a condition of parole Ongoing social service involvement for abuse and neglect | 0 |
A 30-year-old generally healthy woman presents with shortness of breath that had started 2 hours before admission. She has had no health problems in the past besides 2 natural abortions. She had given birth to a healthy child 3 weeks before. On examination, she is apprehensive, tachypneic and tachycardic, her blood pressure is 110/70 and her oxygen saturation 92%. Otherwise, physical examination is unremarkable. Her chest x-ray and CBC are normal. | eligible ages (years): 0.0-999.0, Pregnancy Healthy women First trimester of a normal pregnancy Normal baseline echocardiogram Pregnancy with more than one fetus Any hemodynamically significant cardiac condition Any known systemic disease Poor quality echocardiogram | 0 |
A 30-year-old generally healthy woman presents with shortness of breath that had started 2 hours before admission. She has had no health problems in the past besides 2 natural abortions. She had given birth to a healthy child 3 weeks before. On examination, she is apprehensive, tachypneic and tachycardic, her blood pressure is 110/70 and her oxygen saturation 92%. Otherwise, physical examination is unremarkable. Her chest x-ray and CBC are normal. | eligible ages (years): 0.0-0.192, Development of Control of Breathing Gestational age 23 0/7 6/7 weeks Enrolled in the COT trial at the Health Sciences Centre and the St. Boniface General Hospital in Winnipeg Postnatal age between 21 days and 70 days Informed written consent obtained from at least one of the parents Need for mechanical ventilation, NCPAP or O2 Sepsis or other known causes of apnea | 0 |
A 30-year-old generally healthy woman presents with shortness of breath that had started 2 hours before admission. She has had no health problems in the past besides 2 natural abortions. She had given birth to a healthy child 3 weeks before. On examination, she is apprehensive, tachypneic and tachycardic, her blood pressure is 110/70 and her oxygen saturation 92%. Otherwise, physical examination is unremarkable. Her chest x-ray and CBC are normal. | eligible ages (years): 40.0-999.0, Chronic Obstructive Pulmonary Disease Age at least 40 years COPD Dyspnea, determined by Modified Medical Research Council (MMRC) scale of at least 1 Dyspnea and lung disease process dominated by COPD in judgment of the study physician Participant must meet one of the following Post-bronchodilator forced expiratory volume in 1 second (FEV1) percent less than or equal to 70% predicted Post-bronchodilator forced expiratory volume in 1 second (FEV1) percent >70% predicted and LOTT study physician determines that there is radiologic evidence of emphysema Post-bronchodilator FEV1/forced vital capacity (FVC) less then 0.70 Participant must meet either of the following oxygen saturation Oxygen saturation of at least 89% and no greater than 93% after sitting quietly on room air, without hyperventilation and without pursed lips breathing during oximetry Less than 30 days post treatment for acute exacerbation of COPD as of initiating evaluation (less than 30 days from last dose of antibiotics or since a new or increased dose of systemic corticosteroids was initiated); chronic use of systemic corticosteroids while health is stable is not exclusionary COPD exacerbation requiring antibiotics, new or increased dose of systemic corticosteroids, or oxygen treatment after screening starts and prior to randomization (chronic use of corticosteroids while health is stable is not exclusionary) Less than 30 days post discharge from an acute care hospital after acute care hospitalization for COPD or other condition, as of initiating evaluation (participant may be in a rehab hospital at time of screening) New prescription of supplemental oxygen after screening starts and before randomization Thoracotomy, sternotomy, major cardiopulmonary intervention (e.g., lung resection, open heart surgery, etc.), or other procedure in the 6 months before study entry likely to cause instability of pulmonary status Non-COPD lung disease that affects oxygenation or survival Epworth Sleepiness Scale score greater than 15 Desaturation below 80% for at least 1 minute during the 6-minute walk test Disease or condition expected to cause death, inability to perform procedures for the trial, or inability to comply with therapy within 6 months of random assignment, as judged by the study physician Participation in another intervention study | 0 |
A 30-year-old generally healthy woman presents with shortness of breath that had started 2 hours before admission. She has had no health problems in the past besides 2 natural abortions. She had given birth to a healthy child 3 weeks before. On examination, she is apprehensive, tachypneic and tachycardic, her blood pressure is 110/70 and her oxygen saturation 92%. Otherwise, physical examination is unremarkable. Her chest x-ray and CBC are normal. | eligible ages (years): 50.0-70.0, Healthy Participants of health check program at our hospital who will receive a scheduled X-ray computed tomography examination for either lung (20 cases) or heart (20 cases) Those whose age are under 50 or above 70 year-olds will be excluded | 0 |
A 30-year-old generally healthy woman presents with shortness of breath that had started 2 hours before admission. She has had no health problems in the past besides 2 natural abortions. She had given birth to a healthy child 3 weeks before. On examination, she is apprehensive, tachypneic and tachycardic, her blood pressure is 110/70 and her oxygen saturation 92%. Otherwise, physical examination is unremarkable. Her chest x-ray and CBC are normal. | eligible ages (years): 0.0-999.0, Postpartum Depression Women after term elective cesarean section age < 16 years, preterm (< 37 weeks) delivery, multiple gestation, symptomatic anemia necessitating blood transfusion, significant fetal anomalies or infant not discharged with mother for other reason, preexisting severe chronic maternal illness, preexisting maternal depression and/or current use of antidepressants, other psychiatric illness (e.g. bipolar disease, schizophrenia) or preexisting hemoglobinopathy | 1 |
A 30-year-old generally healthy woman presents with shortness of breath that had started 2 hours before admission. She has had no health problems in the past besides 2 natural abortions. She had given birth to a healthy child 3 weeks before. On examination, she is apprehensive, tachypneic and tachycardic, her blood pressure is 110/70 and her oxygen saturation 92%. Otherwise, physical examination is unremarkable. Her chest x-ray and CBC are normal. | eligible ages (years): 18.0-50.0, Asthma Hypersensitivity for healthy controls Normal lung function, defined as (Knudson 1976/1984 predicted set) FVC of > 80 % of that predicted for gender, ethnicity, age and height FEV1 of > 80 % of that predicted for gender, ethnicity, age and height FEV1/FVC ratio of > .75 Oxygen saturation of > 94 % and normal blood pressure (Systolic between 150 Diastolic between 90-60 mm Hg) Symptom Score no greater than 6 (out of a possible 24) for total symptom score with a value no greater than 2 for any one score Negative methacholine inhalation challenge as performed in the screening protocol. (Less than a 20% decrease in FEV1 at a maximum methacholine concentration of 10 mg/ml) --Negative pregnancy test for females Negative allergy skin test (AST) for allergic asthmatics also Any chronic medical condition considered by the PI as a contraindication to the exposure study including significant cardiovascular disease, diabetes requiring medication, chronic renal disease, or chronic thyroid disease Physician directed emergency treatment for an asthma exacerbation within the preceding 12 months Use of systemic steroid therapy within the preceding 12 months for an asthma exacerbation. All use of systemic steroids in the last year will be reviewed by a study physician Use of inhaled steroids, cromolyn or leukotriene inhibitors (montelukast or zafirlukast) except for use of cromolyn exclusively prior to exercise Use of daily theophylline within the past month Use of tricyclics and MAO inhibitors Pregnancy or nursing a baby Cigarette smoking > 1 pack per month Nighttime symptoms of cough or wheeze greater than 1x/week at baseline (not during a clearly recognized viral induced asthma exacerbation) which would be characteristic of a person of moderate or severe persistent asthma as outlined in the current NHLBI guidelines for diagnosis and management of asthma Exacerbation of asthma more than 2x/week which would be characteristic of a person of moderate or severe persistent asthma as outlined in the current NHLBI guidelines for diagnosis and management of asthma | 0 |
A 30-year-old generally healthy woman presents with shortness of breath that had started 2 hours before admission. She has had no health problems in the past besides 2 natural abortions. She had given birth to a healthy child 3 weeks before. On examination, she is apprehensive, tachypneic and tachycardic, her blood pressure is 110/70 and her oxygen saturation 92%. Otherwise, physical examination is unremarkable. Her chest x-ray and CBC are normal. | eligible ages (years): 18.0-999.0, Pulmonary Embolism Diagnosis of acute PE requires symptoms of PE present <14 days with CT angiography interpreted as positive for acute PE. Initial evaluation for PE must be predicated upon the investigation of new or unexplained cardiopulmonary or chest-related clinical features consistent with PE, including shortness of breath, chest pain, respiratory distress, dizziness, unexplained tachypnea, tachycardia, syncope, cough or hemoptysis. All patients must have CT chest angiography with <2 mm collimation,(36) with or without indirect venography. Pulmonary arterial opacification will be achieved with power injection of non-ionic, low osmolar contrast in an antecubital vein with a timing run; the pitch, voltage, gantry speed and other technical details appropriate for each scanner.(37;38) Images will be interpreted as positive for intrapulmonary arterial filling defect consistent with acute PE using our published definitions(37;38) by a board-certified radiologist with specialty training in body CT or emergency medicine imaging in all cases SBP (SBP)> 89 mm Hg at the time of enrollment. We will allow enrollment for a patient with an SBP < 90 mm Hg prior to enrollment, or a patient with a SBP>80 mm Hg, if the patient has a documented or patient-identified history of low blood pressure and has no symptoms of shock, as described by Jones et al.(39) SaO2% >80% at time of enrollment Patients must have a Borg score greater than 4/10 Altered mental status such that they are unable to provide consent Inability to use a nasal cannula or face mask (e.g., anatomic defect) Supplemental oxygen requirement greater than can be administered via nasal cannula or face mask in order to maintain SaO2 >80% Pregnancy Pneumothorax with decompression A serum mtHb greater than 10% Concurrent therapies including Viagra® (sildenafil) use within the past 24 hours Levitra® (vardenafil) use within the past 24 hours Cialis® (tadalafil) use within the past 72 hours | 1 |
A 30-year-old generally healthy woman presents with shortness of breath that had started 2 hours before admission. She has had no health problems in the past besides 2 natural abortions. She had given birth to a healthy child 3 weeks before. On examination, she is apprehensive, tachypneic and tachycardic, her blood pressure is 110/70 and her oxygen saturation 92%. Otherwise, physical examination is unremarkable. Her chest x-ray and CBC are normal. | eligible ages (years): 0.0-0.019, Adrenal Insufficiency All preterm (28 to 34 week gestation) very low birth weight (birth weight 750-1500grams.) infants born at AIIMS would be eligible for enrollment in the study. Of these infants, those who meet the following would be enrolled Cases: Preterm (28 to 34 week gestation) infants with birth weight between 750 and 1500 grams with shock in the first week of life requiring vasopressor therapy (dopamine or dobutamine or both in a dose of > 10 mcg/kg/min) Controls: Stable preterm (28 to 34 week gestation) infants with birth weight between 750 and 1500 grams who are matched for gestational age, birth weight, postnatal-age Major congenital malformations Mother receiving anticonvulsant / anti-tubercular drugs (rifampicin, isoniazid) Postnatal corticosteroid treatment Refusal to give consent | 0 |
A 30-year-old generally healthy woman presents with shortness of breath that had started 2 hours before admission. She has had no health problems in the past besides 2 natural abortions. She had given birth to a healthy child 3 weeks before. On examination, she is apprehensive, tachypneic and tachycardic, her blood pressure is 110/70 and her oxygen saturation 92%. Otherwise, physical examination is unremarkable. Her chest x-ray and CBC are normal. | eligible ages (years): 0.0-999.0, Thromboembolism Venous Thromboembolism Patients who were treated with fondaparinux pre-, peri and/or postpartum for more than 7 days for VTE prophylaxis or treatment, especially those with a history of abortion, and/or stillbirth, VTE, severe fetal and maternal complications during pregnancy, severe inherited or acquired thrombophilias, long-term anticoagulation (e. g. patients with mechanical heart valves) and/or intolerance to heparins or heparinoids or heparin-induced thrombocytopenia (HIT) Patients who were treated with fondaparinux for less than 7 days Patient who were treated with fondaparinux only postpartum | 0 |
A 30-year-old generally healthy woman presents with shortness of breath that had started 2 hours before admission. She has had no health problems in the past besides 2 natural abortions. She had given birth to a healthy child 3 weeks before. On examination, she is apprehensive, tachypneic and tachycardic, her blood pressure is 110/70 and her oxygen saturation 92%. Otherwise, physical examination is unremarkable. Her chest x-ray and CBC are normal. | eligible ages (years): 0.0-18.0, Mechanical Ventilation Weaning Phase in Children An eligible subject will be considered for into this clinical trial if the attending physician is ready to begin weaning from mechanical ventilation and if the patient fulfils all the following The attending physician thinks that the patient will be able to breathe spontaneously or the patient is already breathing spontaneously No vasopressor or inotropic medication, unless the patient is receiving some digitalin or small doses of dopamine or dobutamine (≤ 5 µg/kg/min) Slight or no endotracheal tube gas-leakage ((Vti Vte)/Vti ≤ 20%) Mechanical ventilation with a plateau pressure ≤ 25 cmH2O over PEEP PEEP ≤ 8 cmH2O FiO2 ≤ 60% in order to obtain pulse oxymetry ≥ 95% PaCO2 < 70 mmHg on the last blood gases Extubation not expected the day of A patient will be excluded from this study a priori if he/she presents one or many of the following The patient fails the pressure-support test (this test is described below in the section entitled "Intervention") Invasive or non invasive mechanical ventilation at home or on hospital ward before PICU admission Child with a tracheotomy Child with an history of mechanical ventilation > 2 months Contemplate withdrawing mechanical ventilation for palliative care Child with tracheobronchomalacia responsible for chronic respiratory failure Child with a severe neuromuscular disease prior to admission or acquired in the PICU and unable to generate a negative pressure of at least cmH20 during inspiration Child with a "do not resuscitate order" and/or "do not reintubate order" is prescribed | 1 |
A 30-year-old generally healthy woman presents with shortness of breath that had started 2 hours before admission. She has had no health problems in the past besides 2 natural abortions. She had given birth to a healthy child 3 weeks before. On examination, she is apprehensive, tachypneic and tachycardic, her blood pressure is 110/70 and her oxygen saturation 92%. Otherwise, physical examination is unremarkable. Her chest x-ray and CBC are normal. | eligible ages (years): 18.0-999.0, Pulmonary Embolism Must be Age greater than or equal to 18 Obtain informed written consent Diagnosed with acute pulmonary embolism (PE) (< 14 days) Catheter-directed therapy (CDT) was performed to treat acute PE | 1 |
A 30-year-old generally healthy woman presents with shortness of breath that had started 2 hours before admission. She has had no health problems in the past besides 2 natural abortions. She had given birth to a healthy child 3 weeks before. On examination, she is apprehensive, tachypneic and tachycardic, her blood pressure is 110/70 and her oxygen saturation 92%. Otherwise, physical examination is unremarkable. Her chest x-ray and CBC are normal. | eligible ages (years): 21.0-999.0, Sleep Apnea, Obstructive Age greater than 21 years Patients scheduled for a procedure that requires analgesia and/or sedation by any route (intravenous, intramuscular, oral, epidural or intrathecal) Patients with an anticipated length of sedation greater than or equal to one hour Patients in the ASA category I through III Patients who only receive propofol, benzodiazepines, and opioids Age less than 21 years Patients whose room air oxygen saturation is <90% Patients receiving post-operative positive airway pressure support Previous allergic/contact reactions to adhesives CHF Moderate or severe valvular disease TIA/CVA Carotid stenosis or endarterectomy Anemia (HCT if available < 30%) Pulmonary hypertension | 0 |
A 30-year-old generally healthy woman presents with shortness of breath that had started 2 hours before admission. She has had no health problems in the past besides 2 natural abortions. She had given birth to a healthy child 3 weeks before. On examination, she is apprehensive, tachypneic and tachycardic, her blood pressure is 110/70 and her oxygen saturation 92%. Otherwise, physical examination is unremarkable. Her chest x-ray and CBC are normal. | eligible ages (years): 0.0-60.0, Fetomaternal Hemorrhage Neonatal Anemia Women admitted for term delivery (delivery between 37 0/7 and 41 6/7 weeks from the last menstrual period) to the Mount Sinai Medical Center Women carrying fetuses with known fetal anomaly Women unable to complete the consent process due to likely precipitous delivery, severe labor discomfort, or fetal distress requiring immediate intervention | 0 |
A 30-year-old generally healthy woman presents with shortness of breath that had started 2 hours before admission. She has had no health problems in the past besides 2 natural abortions. She had given birth to a healthy child 3 weeks before. On examination, she is apprehensive, tachypneic and tachycardic, her blood pressure is 110/70 and her oxygen saturation 92%. Otherwise, physical examination is unremarkable. Her chest x-ray and CBC are normal. | eligible ages (years): 18.0-50.0, Postpartum Hemorrhage All patients planned for elective cesarean delivery under spinal anesthesia All patients who gave written informed consent to participate in this study All patients who refuse to give written informed consent All patients who claim allergy or hypersensitivity to carbetocin or oxytocin All patients with conditions that predispose to uterine atony and postpartum hemorrhage such as placenta previa, multiple gestation, preeclampsia, eclampsia, macrosomia, polyhydramnios, uterine fibroids, previous history of uterine atony and postpartum bleeding, or bleeding diathesis All patients with hepatic, renal, and vascular disease All patients requiring general anesthesia prior to the administration of the study drug | 0 |
A 30-year-old generally healthy woman presents with shortness of breath that had started 2 hours before admission. She has had no health problems in the past besides 2 natural abortions. She had given birth to a healthy child 3 weeks before. On examination, she is apprehensive, tachypneic and tachycardic, her blood pressure is 110/70 and her oxygen saturation 92%. Otherwise, physical examination is unremarkable. Her chest x-ray and CBC are normal. | eligible ages (years): 18.0-999.0, Venous Thromboembolism Postpartum Women must be at high risk for thromboembolism for one of the following reasons Known low risk thrombophilia (Known = diagnosed prior to enrollment and low risk thrombophilia includes heterozygous factor V Leiden or prothrombin gene variant or protein C deficiency or protein S deficiency. If not previously tested then assumed not to have thrombophilia) Immobilization (defined as >90% of waking hours in bed, of a week or more at any point in the antepartum period) OR any two of the following reasons Postpartum infection (fever (temperature>38.5oC) and clinical signs/symptoms of infection and elevated neutrophil count (higher than local lab normal)) Postpartum hemorrhage (Estimated blood loss >1000 ml during delivery and postpartum) Pre-pregnancy BMI >25 kg/m2 Emergency cesarean birth (emergency = not planned prior to onset of labour) Smoking >5 cigarettes per day prior to pregnancy Preeclampsia (blood pressure ≥ 140mmHG systolic and/or ≥90 mmHg diastolic on at least one occasion and proteinuria (1+ on urine dipstick or 300mg/dl or total excretion of 300mg/24 hours) or typical end-organ dysfunction Less than 6 hours or more than 36 hours since delivery at the time of randomization Need for anticoagulation as judged by the local investigator, may but not limited to Personal history of previous provoked or unprovoked VTE (DVT or PE) Continuation of LMWH that was started in the antenatal period for VTE prophylaxis Mechanical heart valve Known high-risk thrombophilia (Known = diagnosed prior to enrolment and high-risk thrombophilia includes deficiency of antithrombin (at least 1 abnormal lab result), persistently positive anticardiolipin antibodies (> 30U/ml on two measurements a minimum of six weeks apart), persistently positive Anti B2 glycoprotein antibodies (> 20U/ml on two measurements a minimum of six weeks apart), persistently positive lupus anticoagulant (positive on two measurements a minimum of six weeks apart), homozygous factor V Leiden (FVL), homozygous prothrombin gene mutation (PGM), compound heterozygosity factor V Leiden (FVL) and prothrombin gene mutations (PGM), more than 1 thrombophilia (any combination of 2 or more: FVL, PGM, protein C deficiency, protein S deficiency). If not previously tested then assumed not to have thrombophilia) Contraindication to heparin therapy, including History of heparin induced thrombocytopenia (HIT) Platelet count of less than 80,000 x 106/L on postpartum Complete Blood Count(CBC) Hemoglobin ≤ 75 g/L on postpartum CBC | 0 |
A 30-year-old generally healthy woman presents with shortness of breath that had started 2 hours before admission. She has had no health problems in the past besides 2 natural abortions. She had given birth to a healthy child 3 weeks before. On examination, she is apprehensive, tachypneic and tachycardic, her blood pressure is 110/70 and her oxygen saturation 92%. Otherwise, physical examination is unremarkable. Her chest x-ray and CBC are normal. | eligible ages (years): 18.0-35.0, Bleeding Venous Thromboembolism Age > 18 years old Delivered by cesarean section (emergency or planned) Signed, informed consent Ready access to a local health service Capable of using Tinzaparin at high risk for thromboembolism (any one of the following) age more than 35 years old obesity (more than 80 kg) parity more than 4 gross varicose veins current infection pre-eclampsia immobility prior to surgery (more than 4 days) Major current disease: including heart or lung disease, cancer,inflammatory bowel disease and nephrotic syndrome Extended major pelvic or abdominal surgery (e.g. cesarean hysterectomy) | 0 |
A 30-year-old generally healthy woman presents with shortness of breath that had started 2 hours before admission. She has had no health problems in the past besides 2 natural abortions. She had given birth to a healthy child 3 weeks before. On examination, she is apprehensive, tachypneic and tachycardic, her blood pressure is 110/70 and her oxygen saturation 92%. Otherwise, physical examination is unremarkable. Her chest x-ray and CBC are normal. | eligible ages (years): 18.0-55.0, Postpartum Hemorrhage All patients planned for elective cesarean delivery under spinal anesthesia All patients who give written informed consent to participate in this study All patients who refuse to give written informed consent All patients who claim allergy or hypersensitivity to carbetocin or oxytocin All patients with conditions that predispose to uterine atony and postpartum hemorrhage such as placenta previa, multiple gestation, preeclampsia, eclampsia, macrosomia, polyhydramnios, uterine fibroids, previous history of uterine atony and postpartum bleeding, or bleeding diathesis All patients with hepatic, renal, and vascular disease All patients requiring general anesthesia prior to the administration of the study drug | 0 |
A 30-year-old generally healthy woman presents with shortness of breath that had started 2 hours before admission. She has had no health problems in the past besides 2 natural abortions. She had given birth to a healthy child 3 weeks before. On examination, she is apprehensive, tachypneic and tachycardic, her blood pressure is 110/70 and her oxygen saturation 92%. Otherwise, physical examination is unremarkable. Her chest x-ray and CBC are normal. | eligible ages (years): 18.0-999.0, Contraception Postpartum Depression Lactation Age > 18 years old and > 24 0/7 weeks pregnant at time of enrollment Planning to deliver at Magee-Womens Hospital and to breastfeed Plans to use DMPA for postpartum contraception for at least 6 months Willing and able to provide informed consent in English and to comply with study protocol Intolerance of irregular vaginal bleeding Severe coagulation disorder Severe liver disease (LFTs >2x upper limits of normal at time of randomization) Contraindications to breastfeeding: maternal HIV infection; active herpes simplex with breast lesions; active varicella; active, untreated tuberculosis; antineoplastic, thyrotoxic, or immunosuppressive medications; concern that the infant may have galactosemia History of breast cancer, reduction or augmentation surgery History of severe clinical depression Multiple gestation | 0 |
A 30-year-old generally healthy woman presents with shortness of breath that had started 2 hours before admission. She has had no health problems in the past besides 2 natural abortions. She had given birth to a healthy child 3 weeks before. On examination, she is apprehensive, tachypneic and tachycardic, her blood pressure is 110/70 and her oxygen saturation 92%. Otherwise, physical examination is unremarkable. Her chest x-ray and CBC are normal. | eligible ages (years): 18.0-999.0, Acute Mountain Sickness acute clinically significant inter-current diseases | 0 |
A 30-year-old generally healthy woman presents with shortness of breath that had started 2 hours before admission. She has had no health problems in the past besides 2 natural abortions. She had given birth to a healthy child 3 weeks before. On examination, she is apprehensive, tachypneic and tachycardic, her blood pressure is 110/70 and her oxygen saturation 92%. Otherwise, physical examination is unremarkable. Her chest x-ray and CBC are normal. | eligible ages (years): 0.0-1.5, Bronchiolitis All children under 18 months of age with a clinical diagnosis of bronchiolitis requiring admission to hospital for observation and oxygen Infants admitted directly to ICU from Emergency Prior positive pressure home ventilation Tracheostomy Nasogastric tubes in situ on admission Upper airway abnormality Congenital heart disease | 0 |
A 30-year-old generally healthy woman presents with shortness of breath that had started 2 hours before admission. She has had no health problems in the past besides 2 natural abortions. She had given birth to a healthy child 3 weeks before. On examination, she is apprehensive, tachypneic and tachycardic, her blood pressure is 110/70 and her oxygen saturation 92%. Otherwise, physical examination is unremarkable. Her chest x-ray and CBC are normal. | eligible ages (years): 19.0-999.0, Air Embolism as A Complication of Medical Care Subject is undergoing ERCP as part of their medical care Subject will be of age 19 or older Subject positioning for the ERCP is prone, thereby inhibiting the performance of the TTE Subject intolerance of the pressure of the TTE probe Subject body habitus interferes with obtaining adequate images to assess for intra-cardiac air | 0 |
A 30-year-old generally healthy woman presents with shortness of breath that had started 2 hours before admission. She has had no health problems in the past besides 2 natural abortions. She had given birth to a healthy child 3 weeks before. On examination, she is apprehensive, tachypneic and tachycardic, her blood pressure is 110/70 and her oxygen saturation 92%. Otherwise, physical examination is unremarkable. Her chest x-ray and CBC are normal. | eligible ages (years): 18.0-999.0, Stress Disorders, Post-Traumatic Anxiety The patient must have given his/her informed and signed consent The patient must be insured or beneficiary of a health insurance plan The patient is available for 12 months of follow up The patient has given birth this day to a premature child (< 36 weeks of gestation and/or < 2 kg birthweight) Separation of child and mother since birth The patient or baby is participating in another study, excepting the studies "OASIS" or "PROM8736" The patient or baby is in an period determined by a previous study The patient is under judicial protection, under tutorship or curatorship The patient or father refuses to sign the consent It is impossible to correctly inform the patient Preexisting maternal psychiatric pathology Major or lethal poly-malformation syndrome Severe pathologies that threaten child survival: pulmonary hypertension, septic shock, anoxic-ischemic brain Any emergency situation preventing patient involvement Mother and/or child not hospitalized at the Nîmes University Hospital | 1 |
A 30-year-old generally healthy woman presents with shortness of breath that had started 2 hours before admission. She has had no health problems in the past besides 2 natural abortions. She had given birth to a healthy child 3 weeks before. On examination, she is apprehensive, tachypneic and tachycardic, her blood pressure is 110/70 and her oxygen saturation 92%. Otherwise, physical examination is unremarkable. Her chest x-ray and CBC are normal. | eligible ages (years): 0.0-999.0, Breastfeeding pregnant women (gestational week 35-36) women with known physical, psychological and/or social illness/problem that result in hospitalization more than 50 hours after delivery women with known pregnancy related illness that result in hospitalization more than 50 hours after delivery Women not understanding or speaking Danish women expecting multiple babies women having decided not to breastfeed women expecting to deliver at another hospital than the one she has been visiting during pregnancy | 0 |
A 30-year-old generally healthy woman presents with shortness of breath that had started 2 hours before admission. She has had no health problems in the past besides 2 natural abortions. She had given birth to a healthy child 3 weeks before. On examination, she is apprehensive, tachypneic and tachycardic, her blood pressure is 110/70 and her oxygen saturation 92%. Otherwise, physical examination is unremarkable. Her chest x-ray and CBC are normal. | eligible ages (years): 19.0-92.0, COPD Men of ages 18 and 30 (Dates of birth 1973-1985) or 55-92 years old (Dates of birth 1911-1948) Must not currently be a cigarette smoker. If an ex-smoker then has not smoked for at least 10 years and consumption were no more than 10 pack years Agrees to volunteers for the study and willing to sign the informed consent form There were negative/normal screening tests for the following Responses to the questionnaire deny current and prior respiratory diseases (including asthma, emphysema, chronic bronchitis, sinusitis and interstitial lung d9sase) and no current respiratory complaints (e.g., cough, wheezing, shortness of breath, allergic rhinitis, and sinusitis). Subjects must not be taking any cardiac medications or admit to a physician-diagnosed cardiac condition "Normal" spirometry measurements with FEV1 & FVC greater than 75% predicted and FEV1/FVC more than 69% Impedance oscillometry were within normal limits "Negative" physical examination of the chest with absence of wheezing and crackles on auscultation of the chest Exhaled nitric oxide concentration is less than 35 ppb for younger and less than 65 ppb for older groups men of: ages < 18, 31-54 and >92 years old current cigarette smokers or exsmokers who have smoked within the past 10 years and/or smoked more than 10 pack/years refusal to volunteer for the study and not willing to sign the informed consent form screening test not considered "normal" by physician/PI and showing one or more of the following one or more positive response to the questionnaire(e.g., current or past respiratory diseases including asthma, emphysema, chronic bronchitis, sinusitis and interstitial lung disease; and/or; current respiratory complaints (e.g., cough, wheezing, shortness of breath, allergic rhinitis, and sinusitis) and/or; admitting to taking a cardiac medication and/or; or physician-diagnosed cardiac condition (e.g., coronary heart disease, angina, myocardial infarction, valvular heart disease, cardiomyopathy, etc.) Abnormal spirometry measurements (FEV1 &/or FVC <75% predicted and FEV1/FVC <69%) "Positive" physical examination (performed by Physician/PI) with presence of wheezing and/or crackles on auscultation of the chest Impulse oscillometry >4 times normal limits Exhaled nitric oxide of >35ppb for younger group and >65 ppb for older group. - | 0 |
A 30-year-old generally healthy woman presents with shortness of breath that had started 2 hours before admission. She has had no health problems in the past besides 2 natural abortions. She had given birth to a healthy child 3 weeks before. On examination, she is apprehensive, tachypneic and tachycardic, her blood pressure is 110/70 and her oxygen saturation 92%. Otherwise, physical examination is unremarkable. Her chest x-ray and CBC are normal. | eligible ages (years): 18.0-50.0, Healthy Healthy males within the age range of 18 to 50 years A body mass index within 18-25 Kg/m2 Given written informed consent to participate in the study Absence of diseases markers of HIV 1 & 2, Hepatitis B & C virus and RPR Absence of significant disease or clinically significant abnormal laboratory values on laboratory evaluation, medical history and physical examination during the screening A normal 12-lead ECG A normal chest X-Ray Comprehension of the nature and purpose of the study and compliance with the requirements of the entire protocol No history or no evidence of hypersensitivity or idiosyncratic reactions to other nitrates or nitrites Blood pressure Systolic> 140 mm Hg and < 110 mm Hg Diastolic< 70 mm Hg > 90 mm Hg History of seizures History of alcohol consumption for more than 2 units/day High caffeine or tobacco consumption History of difficulty with donating blood or difficulty in accessibility of veins Any unusual or abnormal diet, for whatever reason e.g. fasting due to religious reasons Used any pharmacological agents known to significantly induce or inhibit drug metabolizing enzymes within 14 days of the start of the study | 0 |
A 30-year-old generally healthy woman presents with shortness of breath that had started 2 hours before admission. She has had no health problems in the past besides 2 natural abortions. She had given birth to a healthy child 3 weeks before. On examination, she is apprehensive, tachypneic and tachycardic, her blood pressure is 110/70 and her oxygen saturation 92%. Otherwise, physical examination is unremarkable. Her chest x-ray and CBC are normal. | eligible ages (years): 18.0-999.0, Smoking Cessation Pregnancy first or second trimester of pregnancy age 18 or older self-reported tobacco use in the past 90 days or nicotine-dependence in the past year intend to terminate their pregnancy intend to move out of the city within the next 12 months are unable to provide informed consent and participate in English | 0 |
A 30-year-old generally healthy woman presents with shortness of breath that had started 2 hours before admission. She has had no health problems in the past besides 2 natural abortions. She had given birth to a healthy child 3 weeks before. On examination, she is apprehensive, tachypneic and tachycardic, her blood pressure is 110/70 and her oxygen saturation 92%. Otherwise, physical examination is unremarkable. Her chest x-ray and CBC are normal. | eligible ages (years): 18.0-60.0, Pregnancy Complications Weight Gain Healthy pregnant females > 18 years of age with singleton pregnancies (either nulliparous or multiparous) less than 15 weeks gestation a pre pregnancy BMI < 40 kg/m2 (owing to the fact that severe obesity with BMI> 40 may have limitations with respect to physical activity) plans to deliver at a Hamilton or London regional hospital or by home birth and willing to attend research visits at the community site where they were recruited able to tolerate dairy foods approval of primary care provider able to provide signed informed consent unable to understand some English type 1 or type 2 diabetes breastfeeding during current pregnancy pregnancy resulting from in vitro fertilization known contraindications to exercise as recommended by the Canadian clinical practice guidelines for pregnancy severe gastrointestinal diseases or conditions any significant heart, kidney, liver or pancreatic diseases pre-existing diabetes currently smoking a depression score above 10 on the validated Edinburgh depression questionnaire | 0 |
A 30-year-old generally healthy woman presents with shortness of breath that had started 2 hours before admission. She has had no health problems in the past besides 2 natural abortions. She had given birth to a healthy child 3 weeks before. On examination, she is apprehensive, tachypneic and tachycardic, her blood pressure is 110/70 and her oxygen saturation 92%. Otherwise, physical examination is unremarkable. Her chest x-ray and CBC are normal. | eligible ages (years): 18.0-35.0, Retinal Oxygenation Retinal Blood Flow Men and women aged between 18 and 35 years Nonsmokers Normal findings in the medical history and physical examination unless the investigator considers an abnormality to be clinically irrelevant Normal laboratory values unless the investigator considers an abnormality to be clinically irrelevant Normal ophthalmic findings, ametropy < 3 Dpt Regular use of medication, abuse of alcoholic beverages, participation in a clinical trial in the 3 weeks preceding the study (except oral contraceptive) Symptoms of a clinically relevant illness in the 3 weeks before the first study day Presence of any form of anemia Blood donation during the previous 3 weeks Pregnancy | 1 |
A 30-year-old generally healthy woman presents with shortness of breath that had started 2 hours before admission. She has had no health problems in the past besides 2 natural abortions. She had given birth to a healthy child 3 weeks before. On examination, she is apprehensive, tachypneic and tachycardic, her blood pressure is 110/70 and her oxygen saturation 92%. Otherwise, physical examination is unremarkable. Her chest x-ray and CBC are normal. | eligible ages (years): 18.0-999.0, Deep Vein Thrombosis Pulmonary Embolus ≥ 18 years Investigator judges caval filtration clinically indicated for prevention of pulmonary embolism in patient with venous thromboembolic disease or at high risk for venous thromboembolic disease. Patient must meet at least one of the following Anticoagulant therapy is contraindicated, has failed, cannot be achieved or maintained, must be interrupted, resulted in complication, or places the patient at high risk of complication and the patient has Pulmonary embolus Iliocaval deep vein thrombosis (DVT) Severe trauma with high risk of venous thromboembolism including closed head injury, spinal cord injury, or multiple long bone or pelvic fractures Surgery planned with high risk of venous thromboembolism including procedures such as bariatric, orthopedic, or pelvic surgery Past history of thromboembolic disease undergoing surgery Therapeutic anticoagulation can be achieved, but the patient has Venous thromboembolism such as pulmonary embolism or DVT with limited cardiopulmonary reserve Condition that inhibits radiographic visualization of the IVC Known inadequate venous anatomy to allow insertion or retrieval of the filter from the IVC including occlusion of the SVC or jugular veins Known IVC transverse diameter at target implant site > 28 mm Known obstructing abdominal mass or anatomy that is not suitable for infra-renal placement of IVC filter Known duplication of IVC or left-sided IVC Severe kyphosis or scoliosis Known IVC thrombosis extending to renal veins, or renal or gonadal vein thrombosis Risk for septic pulmonary embolism Confirmed bacteremia Estimated Glomerular Filtration Rate (eGFR) < 30 ml/min, or dialysis dependent | 1 |
A 30-year-old generally healthy woman presents with shortness of breath that had started 2 hours before admission. She has had no health problems in the past besides 2 natural abortions. She had given birth to a healthy child 3 weeks before. On examination, she is apprehensive, tachypneic and tachycardic, her blood pressure is 110/70 and her oxygen saturation 92%. Otherwise, physical examination is unremarkable. Her chest x-ray and CBC are normal. | eligible ages (years): 18.0-50.0, Deep Venous Thrombosis Pulmonary Embolism Age: 18 years or older, and Pregnancy confirmed by urinary pregnancy test, and Gestational age < 14 weeks, and Previous objectively confirmed VTE, either unprovoked, in the presence of use of oral contraceptives or estrogen/progestagen use, or related to pregnancy or the postpartum period, or minor risk factors (e.g. long distance travel, minor trauma) Previous VTE related to a major provoking risk factor (e.g. surgery, major trauma or plaster cast immobilisation in the 3 months prior to VTE) as the sole risk factor, or Indication for treatment with therapeutic dose anticoagulant therapy (e.g. treatment of acute VTE; permanent use of therapeutic anticoagulants outside of pregnancy), or Inability to provide informed consent, or Any contraindication listed in the local labelling of LMWH | 0 |
A 30-year-old generally healthy woman presents with shortness of breath that had started 2 hours before admission. She has had no health problems in the past besides 2 natural abortions. She had given birth to a healthy child 3 weeks before. On examination, she is apprehensive, tachypneic and tachycardic, her blood pressure is 110/70 and her oxygen saturation 92%. Otherwise, physical examination is unremarkable. Her chest x-ray and CBC are normal. | eligible ages (years): 0.0-6.0, Transient Tachypnea of the Newborn Late preterm and term infants (post-menstrual age ≥ 34 weeks) delivered by cesarean section or vaginal delivery Diagnosis of TTN Parents signed informed consent Meconium aspiration syndrome Respiratory distress syndrome Congenital heart disease Non respiratory disorders causing tachypnea | 1 |
A 30-year-old generally healthy woman presents with shortness of breath that had started 2 hours before admission. She has had no health problems in the past besides 2 natural abortions. She had given birth to a healthy child 3 weeks before. On examination, she is apprehensive, tachypneic and tachycardic, her blood pressure is 110/70 and her oxygen saturation 92%. Otherwise, physical examination is unremarkable. Her chest x-ray and CBC are normal. | eligible ages (years): 18.0-75.0, Chronic Obstructive Pulmonary Disease chronic obstructive pulmonary disease (COPD), GOLD grade 2-3 residents at low altitude (<800 m) Unstable condition, COPD exacerbation Mild (GOLD 1) or very severe COPD (GOLD 4) requirement for oxygen therapy at low altitude residence hypoventilation pulmonary hypertension more than mild or unstable cardiovascular disease use of drugs that affect respiratory center drive internal, neurologic or psychiatric disease that interfere with protocol compliance including current heavy smoking (>20 cigarettes per day), inability to perform 6 min walk test previous intolerance to moderate altitude (<2600m) Exposure to altitudes >1500m for >2 days within the last 4 weeks before the study | 0 |
A 30-year-old generally healthy woman presents with shortness of breath that had started 2 hours before admission. She has had no health problems in the past besides 2 natural abortions. She had given birth to a healthy child 3 weeks before. On examination, she is apprehensive, tachypneic and tachycardic, her blood pressure is 110/70 and her oxygen saturation 92%. Otherwise, physical examination is unremarkable. Her chest x-ray and CBC are normal. | eligible ages (years): 18.0-999.0, Multiple Pulmonary Emboli Patients referred for CT pulmonary angiogram to pulmonary embolus Class 3 or 4 Congestive Heart Failure Supraventricular tachycardia History of contrast allergy Unable to give informed consent Patients with serum creatinine >1.28 mg/dl without referring physician approval | 2 |
A 30-year-old generally healthy woman presents with shortness of breath that had started 2 hours before admission. She has had no health problems in the past besides 2 natural abortions. She had given birth to a healthy child 3 weeks before. On examination, she is apprehensive, tachypneic and tachycardic, her blood pressure is 110/70 and her oxygen saturation 92%. Otherwise, physical examination is unremarkable. Her chest x-ray and CBC are normal. | eligible ages (years): 0.462-0.846, Respiratory Distress Syndrome, Newborn Bronchopulmonary Dysplasia Ventilator Induced Lung Injury Infants at 24-36 weeks corrected gestational age Already ventilated with high frequency ventilation Requiring FiO2=21%-70% to maintain adequate oxygen saturation Clinical stable o i.e. ventilated on current settings for more than just a few hours with stable but not necessarily normalized blood gases or transcutaneous values and oxygen requirement Parent(s) or guardian able and willing to provide informed consent Major congenital cardiovascular or respiratory abnormalities The attending neonatologist responsible for the baby considers one of the ventilation modes unsuitable for the infant Poor skin integrity precluding use of transcutaneous monitoring Lack of parental signed written informed consent Parents under 18 years of age | 0 |
A 30-year-old generally healthy woman presents with shortness of breath that had started 2 hours before admission. She has had no health problems in the past besides 2 natural abortions. She had given birth to a healthy child 3 weeks before. On examination, she is apprehensive, tachypneic and tachycardic, her blood pressure is 110/70 and her oxygen saturation 92%. Otherwise, physical examination is unremarkable. Her chest x-ray and CBC are normal. | eligible ages (years): 0.462-0.577, Premature Birth Parental consent 0 to 30+0 weeks(agreed dates) gestation born alive Breathing spontaneously at birth or soon after with minimal resuscitation Oxygen saturations >90% by 5 minutes No parental consent Born in poor condition and unlikely to survive Needing resuscitation including intubation and/or chest compressions Not breathing and thus needing intubation Oxygen saturations <90% by 5 minutes <24 weeks gestation >30 weeks gestation | 0 |
A 30-year-old generally healthy woman presents with shortness of breath that had started 2 hours before admission. She has had no health problems in the past besides 2 natural abortions. She had given birth to a healthy child 3 weeks before. On examination, she is apprehensive, tachypneic and tachycardic, her blood pressure is 110/70 and her oxygen saturation 92%. Otherwise, physical examination is unremarkable. Her chest x-ray and CBC are normal. | eligible ages (years): 18.0-999.0, Pregnancy aged 18 or above first-time parents able to speak and read the Chinese language; and Hong Kong residents couples with past or family psychiatric history | 0 |
A 30-year-old generally healthy woman presents with shortness of breath that had started 2 hours before admission. She has had no health problems in the past besides 2 natural abortions. She had given birth to a healthy child 3 weeks before. On examination, she is apprehensive, tachypneic and tachycardic, her blood pressure is 110/70 and her oxygen saturation 92%. Otherwise, physical examination is unremarkable. Her chest x-ray and CBC are normal. | eligible ages (years): 18.0-32.0, Vitamin A Deficiency Pregnant women >-18 years of age with low-risk obstetric Pregnant women expecting a multiple birth Take vitamin A supplements during postpartum apart from study intervention Premature birth Newborn babies with birth defects and / or other serious diseases | 0 |
A 30-year-old generally healthy woman presents with shortness of breath that had started 2 hours before admission. She has had no health problems in the past besides 2 natural abortions. She had given birth to a healthy child 3 weeks before. On examination, she is apprehensive, tachypneic and tachycardic, her blood pressure is 110/70 and her oxygen saturation 92%. Otherwise, physical examination is unremarkable. Her chest x-ray and CBC are normal. | eligible ages (years): 0.0-0.164, Infant Development Full-term newborns (>37 weeks and <41 weeks gestation) Adequate birth weight for his gestational age (between 3-97 percentiles) age: from 0 to 2 months (60 days) Maximum 30 days of exclusive breastfeeding From 30 days on, exclusive or >70% infant formula Normal Apgar score: 7-10 Umbilical pH ≥ of 7.10 Availability to continue during the whole study period Informed consent signed ( parent/legal representative) Participating in other studies Nervous system disorders (hydrocephalic, perinatal hypoxia, intraventricular hemorrhage, neonatal meningitis, septic shock, West Sd...) Gastrointestinal disorders (cow's milk protein allergy, lactose intolerance) Mother's disease history or during pregnancy: neurological and metabolic diseases, diabetes mellitus type 1, hypothyroidism, undernutrition, infections TORCH complex Mothers receiving anxiolytic or antidepressant treatment during pregnancy or other potentially harmful drug treatments for infants' neurodevelopment Infant currently participating in another clinical study Infant's family who in the investigators assessment cannot be expected to comply with the protocol | 0 |
A 30-year-old generally healthy woman presents with shortness of breath that had started 2 hours before admission. She has had no health problems in the past besides 2 natural abortions. She had given birth to a healthy child 3 weeks before. On examination, she is apprehensive, tachypneic and tachycardic, her blood pressure is 110/70 and her oxygen saturation 92%. Otherwise, physical examination is unremarkable. Her chest x-ray and CBC are normal. | eligible ages (years): 18.0-75.0, Precapillary Pulmonary Hypertension Interstitial Lung Disease Precapillary pulmonary hypertension, or interstitial lung disease New York Heart Association class 2-3 Residence at low altitude (<800m) Unstable or exacerbated condition Very severe pulmonary hypertension or interstitial lung disease, New York Heart Association class 4 requirement for oxygen therapy at low altitude residence hypoventilation more than mild or unstable cardiovascular disease use of drugs that affect respiratory center drive internal, neurologic or psychiatric disease that interfere with protocol compliance including current heavy smoking (>20 cigarettes per day), inability to perform 6 min walk test previous intolerance to moderate altitude (<2600m) Exposure to altitudes >1500m for >2 days within the last 4 weeks before the study Pregnant or nursing patients | 0 |
A 30-year-old generally healthy woman presents with shortness of breath that had started 2 hours before admission. She has had no health problems in the past besides 2 natural abortions. She had given birth to a healthy child 3 weeks before. On examination, she is apprehensive, tachypneic and tachycardic, her blood pressure is 110/70 and her oxygen saturation 92%. Otherwise, physical examination is unremarkable. Her chest x-ray and CBC are normal. | eligible ages (years): 18.0-45.0, Postpartum Depressive Mood Postpartum Sexual Function 45 year old women who desire contraception postpartum for at least 6 weeks 45 year old women who choose not to use oral contraceptive medication postpartum for at least 6 weeks for the control group (Medication groups) Breastfeeding (although this may limit participant enrollment, combined oral contraceptives are contraindicated in this population) Delivery by cesarean section Previous history of depression, mood disorders, or psychiatric disorders Any condition (history or presence of) which contraindicates the use of combination OCs, including Thrombophlebitis or thromboembolic disorders, known or suspected clotting disorders, deep vein thrombosis, thrombogenic valvulopathies or rhythm disorders Pulmonary Embolism Cerebrovascular or coronary artery disease or myocardial infarction Diabetes mellitus Migraine headaches with focal, neurological symptoms | 0 |
A 30-year-old generally healthy woman presents with shortness of breath that had started 2 hours before admission. She has had no health problems in the past besides 2 natural abortions. She had given birth to a healthy child 3 weeks before. On examination, she is apprehensive, tachypneic and tachycardic, her blood pressure is 110/70 and her oxygen saturation 92%. Otherwise, physical examination is unremarkable. Her chest x-ray and CBC are normal. | eligible ages (years): 18.0-50.0, Pregnancy Breastfeeding Contraception Cervical Cancer Postpartum Depression Age 18 or above at time of delivery Delivery of live born infant at estimated gestational age (EGA) ≥37wk Postpartum primiparous patients within the first 48 hours after delivery Patient intent to breastfeed Breastfeeding initiated within the first 48 hours of delivery and/or prior to hospital discharge (whichever occurs first) Infant is continuously rooming in with mother from the time of delivery English-speaking Able to read and complete surveys No anticipated discharge from military system, Tricare benefits, or move planned in the upcoming 6 months Willing to render informed consent Patients delivered by the Family Medicine Department (relatively small number in our population who are not followed postpartum by the Department of Obstetrics and Gynecology) Any condition deemed by patient provider to be an absolute contraindication to breastfeeding Maternal HIV/AIDS Planned use of radioactive or chemotherapeutic medications or medication for other medical problems which is contraindicated for delivery Known fetal factor that would impair breastfeeding Fetal mid-facial defects Known fetal chromosomal abnormality Known fetal conditioning resulting in fetal hypotonia Labor and Delivery complications Maternal separation from infant during the first 48 hours postpartum (such as maternal ICU admission, infant NICU admission) | 1 |
A 30-year-old generally healthy woman presents with shortness of breath that had started 2 hours before admission. She has had no health problems in the past besides 2 natural abortions. She had given birth to a healthy child 3 weeks before. On examination, she is apprehensive, tachypneic and tachycardic, her blood pressure is 110/70 and her oxygen saturation 92%. Otherwise, physical examination is unremarkable. Her chest x-ray and CBC are normal. | eligible ages (years): 18.0-999.0, Pregnancy Complicated by Cardiovascular Disorders as Postpartum Condition, Delivered During Previous Episode Breathing-Related Sleep Disorder Interval Contact Agreed to contact for future studies during nuMoM2b and not subsequently withdrawn from the cohort Have pregnancy outcome data from the nuMoM2b study At least 18 years of age (to begin interval contact attempts once nuMoM2b participant reaches age 18) Provision of verbal consent for telephone interview or acknowledgement of consent with completion of the web-based self-administered questionnaire In-clinic Visit Consented for participation in interval contacts and not subsequently withdrawn Between 2 and 3.5 years after the nuMoM2b pregnancy ended Self-report at least 6 months postpartum from any subsequent pregnancy Self-report not currently pregnant Inability or refusal to provide informed consent for the study component | 0 |
A 30-year-old generally healthy woman presents with shortness of breath that had started 2 hours before admission. She has had no health problems in the past besides 2 natural abortions. She had given birth to a healthy child 3 weeks before. On examination, she is apprehensive, tachypneic and tachycardic, her blood pressure is 110/70 and her oxygen saturation 92%. Otherwise, physical examination is unremarkable. Her chest x-ray and CBC are normal. | eligible ages (years): 18.0-999.0, Venous Thrombosis Pulmonary Embolism Lung Neoplasms Patient At least 18 years of age Either gender Diagnosed with resectable lung cancer or metastatic lung disease eligible to complete metastasectomy Undergoing one of the following surgeries: Segmentectomy, wedge resection, lobectomy, bilobectomy or pneumonectomy Competent to understand and sign consent documents Patient Known allergic or anaphylactic reaction to contrast dye, heparin or low molecular weight heparin (LMWH) Under current anticoagulation for venous thromboembolism or other medical conditions Known renal impairment, defined as creatinine clearance value of less than 55ml/min/m2 as calculated by the Cockroft-Gault method History of, or ongoing liver disease, manifested as ascites or previous peritoneal tapping for ascites Pregnant or planning to become pregnant Diagnosed or treated for VTE in the past 3 months prior to surgery Present or previous increase risk of haemorrhage History of previous HIT (heparin induced thrombocytopenia) Platelet count must be below 75,000 Previously inserted Inferior Vena Cava Filter (IVC) filter | 0 |
A 30-year-old generally healthy woman presents with shortness of breath that had started 2 hours before admission. She has had no health problems in the past besides 2 natural abortions. She had given birth to a healthy child 3 weeks before. On examination, she is apprehensive, tachypneic and tachycardic, her blood pressure is 110/70 and her oxygen saturation 92%. Otherwise, physical examination is unremarkable. Her chest x-ray and CBC are normal. | eligible ages (years): 18.0-50.0, Postpartum Hemorrhage Elective cesarean delivery under spinal anesthesia Written informed consent to participate in this study Term pregnancy Refusal to give written informed consent Allergy or hypersensitivity to carbetocin or oxytocin Conditions that predispose to uterine atony and postpartum hemorrhage, such as placenta previa, multiple gestation, preeclampsia, eclampsia, macrosomia, polyhydramnios, uterine fibroids, previous history of uterine atony and postpartum bleeding, or bleeding diathesis Hepatic, renal, and vascular disease | 1 |
A 30-year-old generally healthy woman presents with shortness of breath that had started 2 hours before admission. She has had no health problems in the past besides 2 natural abortions. She had given birth to a healthy child 3 weeks before. On examination, she is apprehensive, tachypneic and tachycardic, her blood pressure is 110/70 and her oxygen saturation 92%. Otherwise, physical examination is unremarkable. Her chest x-ray and CBC are normal. | eligible ages (years): 14.0-44.0, Severe Pre-eclampsia Postpartum. Severe preeclampsia or severe preeclampsia aggregated to chronic hypertension with > 24 weeks of gestation treated with 4-6 grams of magnesium sulfate for impregnation with a minimum of 8 hours continuous of magnesium sulfate before delivery The study begins to terminate pregnancy HELLP syndrome Eclampsia Renal insufficiency Diabetes mellitus Disease of collagen Heart disease | 0 |
A 30-year-old generally healthy woman presents with shortness of breath that had started 2 hours before admission. She has had no health problems in the past besides 2 natural abortions. She had given birth to a healthy child 3 weeks before. On examination, she is apprehensive, tachypneic and tachycardic, her blood pressure is 110/70 and her oxygen saturation 92%. Otherwise, physical examination is unremarkable. Her chest x-ray and CBC are normal. | eligible ages (years): 16.0-999.0, Postpartum Period Age 16-18, married, or Age 18+, in a co-habiting relationship Pregnant 24-36 weeks No obstetric risk factors requiring hospital delivery Lives no more than one hour away on foot, not planning to move from the city Gives informed consent Not meeting Declines to participate | 0 |
A 30-year-old generally healthy woman presents with shortness of breath that had started 2 hours before admission. She has had no health problems in the past besides 2 natural abortions. She had given birth to a healthy child 3 weeks before. On examination, she is apprehensive, tachypneic and tachycardic, her blood pressure is 110/70 and her oxygen saturation 92%. Otherwise, physical examination is unremarkable. Her chest x-ray and CBC are normal. | eligible ages (years): 0.167-4.917, Pneumonia Tachypnea History of cough or difficult breathing < 14 days (observed or reported) AND Respiratory rate ≥ 50 breaths per minute in children 2 to <12 months (on two consecutive readings by independent physicians) OR respiratory rate ≥ 40 breaths per minute in children12 months (on two consecutive readings by independent physicians) AND Written informed consent by a legal guardian Previously enrolled in study Pedal edema History of hospitalization in last two weeks With severe lower chest wall in-drawing Known asthmatics,TB or other severe illness Antibiotics taken in last 48 hours Bulging fontanel Congenital heart disease Any surgical condition requiring hospitalization Out of catchment area | 0 |
A 30-year-old generally healthy woman presents with shortness of breath that had started 2 hours before admission. She has had no health problems in the past besides 2 natural abortions. She had given birth to a healthy child 3 weeks before. On examination, she is apprehensive, tachypneic and tachycardic, her blood pressure is 110/70 and her oxygen saturation 92%. Otherwise, physical examination is unremarkable. Her chest x-ray and CBC are normal. | eligible ages (years): 18.0-45.0, Breastfeeding Maternal age 18-45 years Normal vital signs Contraindications for breastfeeding Significant systemic disease that cause pain or require chronic pain relief | 0 |
A 30-year-old generally healthy woman presents with shortness of breath that had started 2 hours before admission. She has had no health problems in the past besides 2 natural abortions. She had given birth to a healthy child 3 weeks before. On examination, she is apprehensive, tachypneic and tachycardic, her blood pressure is 110/70 and her oxygen saturation 92%. Otherwise, physical examination is unremarkable. Her chest x-ray and CBC are normal. | eligible ages (years): 21.0-59.0, Respiratory Failure Healthy male or female volunteers in the age group Any acute or chronic cardiopulmonary disorder including a simple common cold | 0 |
A 30-year-old generally healthy woman presents with shortness of breath that had started 2 hours before admission. She has had no health problems in the past besides 2 natural abortions. She had given birth to a healthy child 3 weeks before. On examination, she is apprehensive, tachypneic and tachycardic, her blood pressure is 110/70 and her oxygen saturation 92%. Otherwise, physical examination is unremarkable. Her chest x-ray and CBC are normal. | eligible ages (years): 18.0-999.0, Severe Sepsis With Septic Shock Lactate diagnosis in patients with septic shock pregnant women and nursing mothers severe liver failure with child class C using Linezolid pheochromocytoma hematologic malignancy using epinephrine during CVVH treatment | 0 |
A 30-year-old generally healthy woman presents with shortness of breath that had started 2 hours before admission. She has had no health problems in the past besides 2 natural abortions. She had given birth to a healthy child 3 weeks before. On examination, she is apprehensive, tachypneic and tachycardic, her blood pressure is 110/70 and her oxygen saturation 92%. Otherwise, physical examination is unremarkable. Her chest x-ray and CBC are normal. | eligible ages (years): 18.0-999.0, Postpartum Anemia Women above 18 years old after giving birth Women who suffer from iron deficiency anemia, defined as hemoglobin< 10 g/dl without one of the conditions that are described in the Women who suffer from known allergy for iron supplements Women who suffer from anemia not due to iron deficiency Women who suffer from acute infection Women who suffer from liver failure or viral hepatitis Women who suffer from thalassemia or hemoglobinopathies Women who suffer from renal failure Women who suffer from unbalanced thyroid disorder | 1 |
A 30-year-old generally healthy woman presents with shortness of breath that had started 2 hours before admission. She has had no health problems in the past besides 2 natural abortions. She had given birth to a healthy child 3 weeks before. On examination, she is apprehensive, tachypneic and tachycardic, her blood pressure is 110/70 and her oxygen saturation 92%. Otherwise, physical examination is unremarkable. Her chest x-ray and CBC are normal. | eligible ages (years): 18.0-70.0, Hypoxemia Trauma Acute Myocardial Infarction to 70 years of age Male and female volunteers ASA physical status I, II and III Capable and willing to provide written informed consent in English Acute cardiopulmonary disease, as defined by blood pressure greater than 150/90, HR greater than 120 and room air oxygen saturation less than 92 Allergy to lidocaine or adhesive tape History or physical exam finding of nasal polyps Currently taking oral or parenteral anticoagulant medications (other than aspirin) History of frequent nose bleeds Current symptoms of nasal congestion Physical examination findings of rales or wheezing Facial hair that prevents forming a seal with an anesthesia mask | 1 |
A 30-year-old generally healthy woman presents with shortness of breath that had started 2 hours before admission. She has had no health problems in the past besides 2 natural abortions. She had given birth to a healthy child 3 weeks before. On examination, she is apprehensive, tachypneic and tachycardic, her blood pressure is 110/70 and her oxygen saturation 92%. Otherwise, physical examination is unremarkable. Her chest x-ray and CBC are normal. | eligible ages (years): 18.0-999.0, Depression, Postpartum Women who are more than 26 weeks pregnant OR up to 9 months post-birth Outside the limits of the number of weeks pregnant/post birth Living outside England Refusal to participate | 2 |
A 30-year-old generally healthy woman presents with shortness of breath that had started 2 hours before admission. She has had no health problems in the past besides 2 natural abortions. She had given birth to a healthy child 3 weeks before. On examination, she is apprehensive, tachypneic and tachycardic, her blood pressure is 110/70 and her oxygen saturation 92%. Otherwise, physical examination is unremarkable. Her chest x-ray and CBC are normal. | eligible ages (years): 0.0-999.0, Thrombophilia Associated With Pregnancy Perioperative/Postoperative Complications Venous Thrombosis Pulmonary Embolism Other Specified Risk Factors in Pregnancy Deep Vein Thrombosis All pregnant women hospitalized Previous use of anticoagulation | 0 |
A 30-year-old generally healthy woman presents with shortness of breath that had started 2 hours before admission. She has had no health problems in the past besides 2 natural abortions. She had given birth to a healthy child 3 weeks before. On examination, she is apprehensive, tachypneic and tachycardic, her blood pressure is 110/70 and her oxygen saturation 92%. Otherwise, physical examination is unremarkable. Her chest x-ray and CBC are normal. | eligible ages (years): 1.0-18.0, Noninvasive Ventilation All pediatric patients between one and 18 year of age Requirement for insertion of an endotracheal tube American Society of Anesthesiologists (ASA) class I to III Failure to obtain parental consent or patient assent when appropriate (in general, children over 6 years of age) ASA IV Patients with any cardiac pathology Patients with any respiratory pathology Patients with any form of chest deformity, for example, pectus excavatum, pectus carinatum, scoliosis Patients who had previous cardiac or thoracic surgery | 0 |
A 30-year-old generally healthy woman presents with shortness of breath that had started 2 hours before admission. She has had no health problems in the past besides 2 natural abortions. She had given birth to a healthy child 3 weeks before. On examination, she is apprehensive, tachypneic and tachycardic, her blood pressure is 110/70 and her oxygen saturation 92%. Otherwise, physical examination is unremarkable. Her chest x-ray and CBC are normal. | eligible ages (years): 18.0-999.0, Pulmonary Thromboembolism Women with clinically suspected pulmonary embolism (PE) during the first 6 weeks postpartum, without any sign of severe PE (shock, hypotension), referred for CT angiography Absence of contraindication to iodinated contrast medium injection Age > 18 years Health insurance Possibility to have 3-month follow-up Obtention of written informed consent (ability to give consent) Anticoagulation at therapeutic dosage for another reason than the suspicion of PE New pregnancy (βHCG positive before CT angiography) Contrast medium extravasation during injection CTA or CTV not performed according to the study requirements | 1 |
An 85-year-old man is brought to the ER because of gradual decrease in his level of consciousness. In the last 3 days he stopped walking and eating by himself. He has had no fever, cough, rash or diarrhea. His daughter recalls that he had been involved in a car accident 3 weeks prior to his admission and had a normal head CT at that time. | eligible ages (years): 25.0-75.0, Osteoporosis females 25-75 years of age with no known bone disorders history of vertebral fractures or nonvertebral fractures without trauma prescription medications for prevention of osteoporosis (including vitamin D other than multivitamin and estrogen) history of malignancy other than basal cell or squamous cell cancer of the skin use of steroids or anticonvulsants in the 6 months prior to enrollment | 0 |
An 85-year-old man is brought to the ER because of gradual decrease in his level of consciousness. In the last 3 days he stopped walking and eating by himself. He has had no fever, cough, rash or diarrhea. His daughter recalls that he had been involved in a car accident 3 weeks prior to his admission and had a normal head CT at that time. | eligible ages (years): 60.0-80.0, Alzheimer's Disease Individuals of either sex, with a high school education, and between the ages of 60 and 80 years living in the New York City metropolitan area Minimum of 12 years education Participants will be classified as within normal limits on medical, psychiatric and neuropsychological examinations (performance that is better than -1.5 sd of the NYU norm based WMS-R delayed memory index) Participants will have a global deterioration scale (GDS)=1 or 2. Those enrolled in the High-Risk group will have a GDS=2 and have a score of >25 on the Memory Complaint Questionnaire (MCQ). In high risk memory loss cases, an informed family member or caregiver will be interviewed to confirm that the participant can perform specific tasks Past history or MRI evidence of brain damage including significant trauma, stroke, hydrocephalus, lacunar infarcts, seizures, mental retardation or serious neurological disorder Significant history of alcoholism or drug abuse History of psychiatric illness (e.g., schizophrenia, mania, Post-Traumatic Stress Disorder [PTSD], or depression) Any focal neurological signs or significant neuropathology A score of 4 or greater on the Modified Hachinski Ischemia Scale, indicative of cerebrovascular disease A total score of 16 or more on the Hamilton Depression Scale to possible cases of primary depression Evidence of clinically relevant and uncontrolled hypertensive, cardiac, pulmonary, vascular, metabolic or hematologic conditions Physical impairment of such severity as to adversely affect the validity of psychological testing Hostility or refusal to cooperate Any prosthetic devices (e.g., pacemaker or surgical clips) that could be affected by the magnetic field employed during MRI imaging | 0 |
An 85-year-old man is brought to the ER because of gradual decrease in his level of consciousness. In the last 3 days he stopped walking and eating by himself. He has had no fever, cough, rash or diarrhea. His daughter recalls that he had been involved in a car accident 3 weeks prior to his admission and had a normal head CT at that time. | eligible ages (years): 65.0-999.0, Postoperative Complications Delirium Community-dwelling individuals aged 65 or older Admitted to Methodist Hospital for surgical repair of hip fracture No evidence of delirium at admission to hospital MMSE total score below 24 points after adjustment for education and age Consent to participate in the study Severely demented as defined by MMSE score below 10 Metastatic cancer or other comorbid illnesses likely to reduce life expectancy to under 6 months Multiple trauma or pathological fractures Aphasic, legally blind, or deaf Use of Donepezil or other cholinesterase inhibitors within one month prior to surgery Allergy to Donepezil | 0 |
An 85-year-old man is brought to the ER because of gradual decrease in his level of consciousness. In the last 3 days he stopped walking and eating by himself. He has had no fever, cough, rash or diarrhea. His daughter recalls that he had been involved in a car accident 3 weeks prior to his admission and had a normal head CT at that time. | eligible ages (years): 30.0-60.0, Chronic Pain age driving licence driving experience normal vision right-handed fluently Dutch speaking psychological or physical disorder drug or alcohol abuse psychotropic medication use excessive smoking, drinking | 0 |
An 85-year-old man is brought to the ER because of gradual decrease in his level of consciousness. In the last 3 days he stopped walking and eating by himself. He has had no fever, cough, rash or diarrhea. His daughter recalls that he had been involved in a car accident 3 weeks prior to his admission and had a normal head CT at that time. | eligible ages (years): 55.0-999.0, Multiple Trauma Cardiovascular Diseases Aged All trauma patients admitted to the ICU > 55 years of age with a primary diagnosis of injury will be screened on admission as study candidates Patients will be excluded if they have non-survivable injuries, are receiving comfort care only, have an advanced directive limiting aggressive care, heart block, severe asthma, bradycardia (< 60 bpm), are on beta-blocker therapy, or are having an acute or evolving myocardial infarction | 1 |
An 85-year-old man is brought to the ER because of gradual decrease in his level of consciousness. In the last 3 days he stopped walking and eating by himself. He has had no fever, cough, rash or diarrhea. His daughter recalls that he had been involved in a car accident 3 weeks prior to his admission and had a normal head CT at that time. | eligible ages (years): 16.0-75.0, Traumatic Brain Injury Cerebral Infarction Cerebral Hemorrhage One week following Traumatic Brain Injury Cerebro Vascular Accident Subsequent brain CT showed cerebral cortex injury A known ailment of the central nervous system Use of medications or illicit drugs that significantly affect the central nervous system tourist or temporary residents not available for follow-up For MRI examinations: heart pacemaker, metal implants, or metal shrapnel | 2 |
An 85-year-old man is brought to the ER because of gradual decrease in his level of consciousness. In the last 3 days he stopped walking and eating by himself. He has had no fever, cough, rash or diarrhea. His daughter recalls that he had been involved in a car accident 3 weeks prior to his admission and had a normal head CT at that time. | eligible ages (years): 0.083-15.0, Injuries and Wounds All asymptomatic trauma patients from 0 to 15 years old Any pediatric trauma patients with clinical indications for CT scan | 0 |
An 85-year-old man is brought to the ER because of gradual decrease in his level of consciousness. In the last 3 days he stopped walking and eating by himself. He has had no fever, cough, rash or diarrhea. His daughter recalls that he had been involved in a car accident 3 weeks prior to his admission and had a normal head CT at that time. | eligible ages (years): 65.0-999.0, Dementia 65 years of age or older Diagnosed with dementia by a physician Mini-Mental State Examination score of 23 points or less Capable of participating at least once a week for 6 weeks in succession Management of a medical risk required Impaired ability to pedal the ergometer because of an orthopedic or surgical disease of the lower extremities or central nerve paralysis Never having been on a bicycle, and incapable of pedaling well | 0 |
An 85-year-old man is brought to the ER because of gradual decrease in his level of consciousness. In the last 3 days he stopped walking and eating by himself. He has had no fever, cough, rash or diarrhea. His daughter recalls that he had been involved in a car accident 3 weeks prior to his admission and had a normal head CT at that time. | eligible ages (years): 65.0-85.0, Mental Health Geriatrics valid Ontario driver's license active driver (greater than or equal to three times per week) written, informed consent lives in Toronto/Thunder Bay healthy Male between 65-75 years old cognitive impairment psychiatric history sleep disorder history substance abuse neurological history medical illness ophthalmological disease psychoactive medications contra-indications to Donepezil experience car/motion sickness | 0 |
An 85-year-old man is brought to the ER because of gradual decrease in his level of consciousness. In the last 3 days he stopped walking and eating by himself. He has had no fever, cough, rash or diarrhea. His daughter recalls that he had been involved in a car accident 3 weeks prior to his admission and had a normal head CT at that time. | eligible ages (years): 18.0-999.0, Advanced Cancer Delirium Presence of advanced cancer, defined as local recurrent and/or metastatic History of an episode of delirium during the patient's current inpatient admission, diagnosis of delirium will be made by one of the palliative care specialists according to DSM-IV-TR criteria If the patient has a complete recovery from the episode of delirium, the patient must be approached within 3 days for the possibility of in study. "Complete recovery" will be defined as diagnosis of complete resolution of all symptoms of delirium according to DSM-IV-TR by one of the palliative care specialists Ability to communicate in the English language Caregiver who is 18 years of age or older (assessments used in this study have not been validated in pediatric population), is able to communicate in English and comprehend the assessment questionnaire, and is at the bedside for a significant length of time (approximately 4 hours) each day during the delirium episode. Both the patient and their caregiver must agree to participate for in the study Written informed consent signed by the patients and the participating caregivers MDAS [Memorial Delirium Assessment Scale] < 13 (Scores of 13 or above likely reflect the presence of delirium) Patients will be recruited from the palliative care mobile team or the inpatient palliative care unit Refusal of both the patient and their caregiver to complete assessments Inability to complete assessment due to sensorial deficits other than cognition; e.g. blindness, deafness, aphasia, etc., that might impact the patient's ability to recall the episode of delirium | 0 |
An 85-year-old man is brought to the ER because of gradual decrease in his level of consciousness. In the last 3 days he stopped walking and eating by himself. He has had no fever, cough, rash or diarrhea. His daughter recalls that he had been involved in a car accident 3 weeks prior to his admission and had a normal head CT at that time. | eligible ages (years): 0.0-999.0, Accidental Falls At least one fall in the last 6 months Living in their own home or in a home for the aged Availability of a primary caregiver caring for the patient at least once a week Ability to walk 15 meters independently (use of a walking aid is permitted) Life expectancy of more than 6 months, as judged by their geriatrician Dyads of patients and caregivers in whom outcome assessment is highly unlikely to succeed, for example because they proved not to be able to register falls in the three months before randomization, will be excluded MMSE score of less than 15 On the waiting list for a nursing home | 0 |
An 85-year-old man is brought to the ER because of gradual decrease in his level of consciousness. In the last 3 days he stopped walking and eating by himself. He has had no fever, cough, rash or diarrhea. His daughter recalls that he had been involved in a car accident 3 weeks prior to his admission and had a normal head CT at that time. | eligible ages (years): 18.0-999.0, Normal Pressure Hydrocephalus Walking difficulties in both legs which has developed gradually, not explained by other conditions, either in combination with mental impairment and urinary incontinence Brain CT or MRI findings of enlarged ventricles compared to established standards (minimum Evans ratio of 0.30 as measured by reviewing films) Mental impairment must be mild to moderate, emerging with or after the walking difficulties Age > or = 18 years old MMSE (Mini-mental status exam): < or = 10 Urinary incontinence No or only minimal walking difficulties combined with severe dementia Severe medical problems with limited life expectancy (less than six months) Contraindications to surgery Lack of informed consent | 0 |
An 85-year-old man is brought to the ER because of gradual decrease in his level of consciousness. In the last 3 days he stopped walking and eating by himself. He has had no fever, cough, rash or diarrhea. His daughter recalls that he had been involved in a car accident 3 weeks prior to his admission and had a normal head CT at that time. | eligible ages (years): 18.0-65.0, TBI (Traumatic Brain Injury) Post Concussion Syndrome Post Traumatic Stress Disorder Chronic Post Traumatic Stress Disorder Adults, 18-65 years old One or more mild-moderate TBI's characterized by loss of consciousness due to blast injury that is a minimum of one year old and occurred after 9/11/2001 Absence of acute cardiac arrest or hemorrhagic shock at time of TBI Absence of intracranial neurosurgery post-TBI Disability Rating Scale of 0-3 Negative Michigan Alcohol Screening Test (MAST) Negative Drug Abuse Screening Test (DAST) Negative urine toxicology screen for drugs of abuse Negative pregnancy test in females Otherwise good health Pulmonary disease that precludes HBOT Unstable medical conditions that are contraindicated in HBOT Severe confinement anxiety Pregnancy Other pre-TBI neurological diagnoses Pre or post TBI history of substance abuse Pre or post TBI history of alcoholism Participation in another experimental trial with active intervention High probability of inability to complete the experimental protocol Previous HBOT | 0 |
An 85-year-old man is brought to the ER because of gradual decrease in his level of consciousness. In the last 3 days he stopped walking and eating by himself. He has had no fever, cough, rash or diarrhea. His daughter recalls that he had been involved in a car accident 3 weeks prior to his admission and had a normal head CT at that time. | eligible ages (years): 10.0-85.0, Aging Absence of the basic pathology that interferes directly in the balance Neurological changes Cognitive impairment Orthopedic injury Use of orthoses for lower limb Obesity Exercise frequently (more than twice a week) The bearer of any commitment to stay in their standing position | 0 |
An 85-year-old man is brought to the ER because of gradual decrease in his level of consciousness. In the last 3 days he stopped walking and eating by himself. He has had no fever, cough, rash or diarrhea. His daughter recalls that he had been involved in a car accident 3 weeks prior to his admission and had a normal head CT at that time. | eligible ages (years): 18.0-999.0, Intracranial Hemorrhages Spontaneous ICH (intraparenchymal), subdural hematoma (SDH) diagnosed by CT scanning ≤ 12 hours after onset of symptoms. In case of unknown time of symptom onset: time between last seen in healthy condition and first CCT ≤ 12 hours Therapy receiving vitamin K antagonists (VKA) International Normalized Ratio (INR) ≥ 2 Signed informed consent form, or signed informed consent by a legal representative, judicial consent in cases where no legal representative is available in time, or consent of an independent physician familiar with the indication in cases where the first three possibilities can not be realized Patients with ICH not related to vitamin-K antagonist therapy or Patients with secondary ICH related to infarction, hemophilia or other coagulopathy, tumor, hemorrhagic infarction, cerebrovenous thrombosis, aneurysm, arteriovenous malformations (AVM) or severe trauma Deep Coma (GCS ≤ 5) at the time of admission or before intubation if intubated outside the hospital Known previous disability (mRS > 2 before stroke occurred) Acute myocardial ischemia, acute septicemia, acute crush injury, any history of acute hemorrhagic disseminated intravascular coagulation, acute thrombotic stroke Known history of intermittent claudication Known recent thrombotic event < 30 days Acute or known congestive heart failure (NYHA III, IV) Pulmonary edema Known liver failure (child-pugh-score C) | 0 |
An 85-year-old man is brought to the ER because of gradual decrease in his level of consciousness. In the last 3 days he stopped walking and eating by himself. He has had no fever, cough, rash or diarrhea. His daughter recalls that he had been involved in a car accident 3 weeks prior to his admission and had a normal head CT at that time. | eligible ages (years): 18.0-999.0, Post-Traumatic Stress Disorder OEF/OIF Veteran meets DSM-IV for PTSD control group does not meet for PTSD prior history of significant head injury (LOC > 30 minutes) or other neurological disorder (e.g., stroke, seizure, multiple sclerosis), learning disability or confirmed diagnosis of ADHD contraindication to MR imaging, failed malingering tests during testing, or a history of severe mental illness (i.e., Schizophrenia, Bipolar Disorder) individuals will be excluded if in the 30 days prior to the initial interview if they do not have stable housing (i.e., staying in same residence) have medication changes or have had a psychiatric hospitalization participants who meet DSM-IV for substance dependence will be excluded from the study individuals will also receive urine toxicology and Breathalyzer testing as the first procedure on the evaluation day (pre and post treatment and at 3 month follow up); participants who test positive for alcohol or recent substance use (e.g., methamphetamine) or report significant levels of drug or alcohol use if they are unable to abstain from substance use at three consecutive visits veterans who are currently engaged in therapy treatment for PTSD | 0 |
An 85-year-old man is brought to the ER because of gradual decrease in his level of consciousness. In the last 3 days he stopped walking and eating by himself. He has had no fever, cough, rash or diarrhea. His daughter recalls that he had been involved in a car accident 3 weeks prior to his admission and had a normal head CT at that time. | eligible ages (years): 18.0-999.0, Traumatic Brain Injury Post-Traumatic Stress Disorder At least 18 years of age and non-active duty Either Normal (no history of head injury) -OR- TBI (injury since Jan. 1, 2002) Incapable of informed consent or absence of legally authorized representative Incarcerated (or subject to court supervision) Known allergy to protocol contrast/imaging agent (or pregnant and unable to receive agent) MRI incompatible (i.e. implant, metal, > 300 lbs, severe claustrophobia) | 2 |
Subsets and Splits
No saved queries yet
Save your SQL queries to embed, download, and access them later. Queries will appear here once saved.