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A 58-year-old African-American woman presents to the ER with episodic pressing/burning anterior chest pain that began two days earlier for the first time in her life. The pain started while she was walking, radiates to the back, and is accompanied by nausea, diaphoresis and mild dyspnea, but is not increased on inspiration. The latest episode of pain ended half an hour prior to her arrival. She is known to have hypertension and obesity. She denies smoking, diabetes, hypercholesterolemia, or a family history of heart disease. She currently takes no medications. Physical examination is normal. The EKG shows nonspecific changes. | eligible ages (years): 18.0-999.0, Acute Renal Failure all ICU patients requiring renal replacement therapy patient denies informed consent patient not requiring intensive care therapy kidney transplanted patients chronic renal failure (serum creatinine > 3mg/dl) | 0 |
A 58-year-old African-American woman presents to the ER with episodic pressing/burning anterior chest pain that began two days earlier for the first time in her life. The pain started while she was walking, radiates to the back, and is accompanied by nausea, diaphoresis and mild dyspnea, but is not increased on inspiration. The latest episode of pain ended half an hour prior to her arrival. She is known to have hypertension and obesity. She denies smoking, diabetes, hypercholesterolemia, or a family history of heart disease. She currently takes no medications. Physical examination is normal. The EKG shows nonspecific changes. | eligible ages (years): 35.0-75.0, Coronary Heart Disease Male or female; age 35-75 years having angina (Canada Cardiovascular Society Class II-IV) Essential Hypertension defined as taking at least 1 anti-hypertensive medication, or average systolic blood pressure ≥140 mm Hg, or diastolic blood pressure ≥90 mmHg ST-T changes of LVH (Romhilt-Estes or Framingham Heart Study with typical LV strain pattern, or isoelectric, inverted or biphasic T waves) ST-T changes of ischemia in resting ECG (ST depression, isoelectric, biphasic, negative or inverted T-waves) Serum potassium < 5.0 mmol/L prior to randomization Negative pregnancy test in child-bearing potential women Willing to comply with scheduled visits Informed consent form signed by the subject Resistance hypertension despite 3-drugs treatment Myocardial infarction in past 90 days Coronary artery bypass graft surgery in past 90 days Atrial fibrillation with a resting heart rate > 90 bpm Percutaneous coronary intervention in past 30 days Implanted Pacemaker Stroke in past 90 days Left or Right Ventricular Branch Block Aldosterone antagonist or K sparing drug in last 7 days Intolerance to amiloride | 1 |
A 58-year-old African-American woman presents to the ER with episodic pressing/burning anterior chest pain that began two days earlier for the first time in her life. The pain started while she was walking, radiates to the back, and is accompanied by nausea, diaphoresis and mild dyspnea, but is not increased on inspiration. The latest episode of pain ended half an hour prior to her arrival. She is known to have hypertension and obesity. She denies smoking, diabetes, hypercholesterolemia, or a family history of heart disease. She currently takes no medications. Physical examination is normal. The EKG shows nonspecific changes. | eligible ages (years): 60.0-85.0, Low Back Pain Obesity chronic low back pain for >6 months >3 pain episodes per week waist circumferences ≥102 cm for men waist circumferences ≥ 88 cm for women willing and able to participate in regular exercise for 14 weeks using pain medications to control low back pain free of abnormal cardiovascular responses during a screening graded maximal walk test unable to walk participating in regular resistance exercise training (>3X week) in the past 6 months pain symptoms are too severe and prevent strength testing or walking acute back injury spinal stenosis that precludes walking one block due to neurogenic claudication back surgery within the past 2 years current use of weight loss interventions (drugs; exercise interventions) | 0 |
A 58-year-old African-American woman presents to the ER with episodic pressing/burning anterior chest pain that began two days earlier for the first time in her life. The pain started while she was walking, radiates to the back, and is accompanied by nausea, diaphoresis and mild dyspnea, but is not increased on inspiration. The latest episode of pain ended half an hour prior to her arrival. She is known to have hypertension and obesity. She denies smoking, diabetes, hypercholesterolemia, or a family history of heart disease. She currently takes no medications. Physical examination is normal. The EKG shows nonspecific changes. | eligible ages (years): 0.0-70.0, Ischemic Heart Disease Obesity obesity Ischemic Heart disease Signed informed consent Visual or manual limitations that preclude reading and writing Unwilling to participate | 2 |
A 58-year-old African-American woman presents to the ER with episodic pressing/burning anterior chest pain that began two days earlier for the first time in her life. The pain started while she was walking, radiates to the back, and is accompanied by nausea, diaphoresis and mild dyspnea, but is not increased on inspiration. The latest episode of pain ended half an hour prior to her arrival. She is known to have hypertension and obesity. She denies smoking, diabetes, hypercholesterolemia, or a family history of heart disease. She currently takes no medications. Physical examination is normal. The EKG shows nonspecific changes. | eligible ages (years): 18.0-999.0, Ovarian Cancer Subjects who aged 18 years or older Subjects whose written informed consent was obtained complying with the local regulatory requirements prior to their participation in the trial Subjects who have histologically or cytologically confirmed unresectable or metastatic epithelial cancer of the exocrine pancreas. High-quality contrast-enhanced CT scanning is required to evaluate resectability. Measurable disease is not required Subjects who have received prior radiation therapy (XRT) for pancreatic cancer unless progression was documented after XRT and 6 weeks have elapsed between completion of XRT and start of trial medication Subjects who have had systemic treatment such as chemotherapy or immunotherapy, for pancreatic cancer. However, prior use of chemotherapy, e.g. 5-FU or capecitabine, for radiation sensitization is allowed. If gemcitabine was given in the adjuvant setting, only subjects relapsed with cancer after 6 months of completing the last dose of gemcitabine can participate in the trial Subjects who have had a major surgery within 2 weeks prior to the screening/baseline visit | 0 |
A 58-year-old African-American woman presents to the ER with episodic pressing/burning anterior chest pain that began two days earlier for the first time in her life. The pain started while she was walking, radiates to the back, and is accompanied by nausea, diaphoresis and mild dyspnea, but is not increased on inspiration. The latest episode of pain ended half an hour prior to her arrival. She is known to have hypertension and obesity. She denies smoking, diabetes, hypercholesterolemia, or a family history of heart disease. She currently takes no medications. Physical examination is normal. The EKG shows nonspecific changes. | eligible ages (years): 18.0-80.0, Functional Chest Pain Age 18 to 80, male or female Patients must fulfill the Rome III for Functional Chest Pain of Presumed Esophageal Origin for the previous 3 months (with symptom onset at least 6 months before diagnosis), including all of the following Midline chest pain or discomfort that is not of burning quality Absence of evidence that gastroesophageal reflux is the cause of the symptom Absence of histopathology-based esophageal motility disorders Persistent symptoms despite a trial of antidepressant therapy, as defined by either chest pain despite at least a continuous 4-week trial of at least one antidepressant within the last 6 months; or intolerance of at least one antidepressant within the last 6 months Negative cardiac evaluation (negative cardiac stress test or negative coronary angiogram) Negative gastrointestinal evaluation for cause of the pain, defined by absence of Los Angeles grade C or D erosive esophagitis on endoscopy, persistent chest pain on PPI therapy, and no association of chest pain with reflux episodes on an ambulatory pH or pH-impedance study, defined as a symptom index <50% or symptom association probability <95% for chest pain Severe co-morbid illness (cardiac, pulmonary, renal, hematologic, hepatic) Prior treatment with hypnosis/hypnotherapy for a medical condition Prior major thoracic surgery Prior diagnosis of or treatment for dissociative disorders, post-traumatic stress disorder, borderline personality disorder, or other psychiatric disorders that psychotic features Pregnancy or planned pregnancy within the upcoming 3 months Inability or unwillingness to give informed consent | 0 |
A 58-year-old African-American woman presents to the ER with episodic pressing/burning anterior chest pain that began two days earlier for the first time in her life. The pain started while she was walking, radiates to the back, and is accompanied by nausea, diaphoresis and mild dyspnea, but is not increased on inspiration. The latest episode of pain ended half an hour prior to her arrival. She is known to have hypertension and obesity. She denies smoking, diabetes, hypercholesterolemia, or a family history of heart disease. She currently takes no medications. Physical examination is normal. The EKG shows nonspecific changes. | eligible ages (years): 18.0-999.0, Atherosclerosis Major Men Obese BMI>30 No aspirin treatment before Coronary exploration: coronary angiography or tomography coronary angiography Chest pain like stable angina Women Severe hepatic insufficiency Inflammatory disease Neoplasia Protein S deficiency Aspirin treatment 10 days before Oral anticoagulant treatment at Heparin or low molecular weight heparin treatment at | 0 |
A 58-year-old African-American woman presents to the ER with episodic pressing/burning anterior chest pain that began two days earlier for the first time in her life. The pain started while she was walking, radiates to the back, and is accompanied by nausea, diaphoresis and mild dyspnea, but is not increased on inspiration. The latest episode of pain ended half an hour prior to her arrival. She is known to have hypertension and obesity. She denies smoking, diabetes, hypercholesterolemia, or a family history of heart disease. She currently takes no medications. Physical examination is normal. The EKG shows nonspecific changes. | eligible ages (years): 18.0-999.0, Cystic Fibrosis Back Pain Neck Pain Chest Pain Diagnosis of cystic fibrosis ( positive sweat test and / or presence of 2 disease causing mutations in the CFTR gene Age > 18 years Patient with chronic chest , neck or back pain Written Informed Consent with health insurance regular follow-up by an osteopathic physician in the previous 3 months patients awaiting lung transplantation history of lung transplantation pregnancy understanding disorders preventing the patient to apply the study participation in another clinical interventional study protocol | 0 |
A 58-year-old African-American woman presents to the ER with episodic pressing/burning anterior chest pain that began two days earlier for the first time in her life. The pain started while she was walking, radiates to the back, and is accompanied by nausea, diaphoresis and mild dyspnea, but is not increased on inspiration. The latest episode of pain ended half an hour prior to her arrival. She is known to have hypertension and obesity. She denies smoking, diabetes, hypercholesterolemia, or a family history of heart disease. She currently takes no medications. Physical examination is normal. The EKG shows nonspecific changes. | eligible ages (years): 10.0-999.0, Allergic Conjunctivitis Positive bilateral conjunctival allergen challenge (CAC) reaction Known contraindications or sensitivities to the study medication or its components Any ocular condition that, in the opinion of the investigator, could affect the subjects safety or trial parameters Use of disallowed medications during the period indicated prior to the study enrollment or during the study | 0 |
A 58-year-old African-American woman presents to the ER with episodic pressing/burning anterior chest pain that began two days earlier for the first time in her life. The pain started while she was walking, radiates to the back, and is accompanied by nausea, diaphoresis and mild dyspnea, but is not increased on inspiration. The latest episode of pain ended half an hour prior to her arrival. She is known to have hypertension and obesity. She denies smoking, diabetes, hypercholesterolemia, or a family history of heart disease. She currently takes no medications. Physical examination is normal. The EKG shows nonspecific changes. | eligible ages (years): 18.0-79.0, Angina Pectoris Coronary Artery Disease Type 2 Diabetes Mellitus Written informed consent Males and females aged 18 to 79 years Able to perform a Sheffield Modified Bruce Treadmill Exercise Protocol At least a 3-months history of chronic stable angina triggered by physical effort and relieved by rest and/or sublingual nitroglycerin Coronary artery disease documented by one or more of the following Angiographic evidence of ≥ 50% stenosis of one or more major coronary arteries History of myocardial infarction (MI) documented by positive CK-MB enzymes, troponins, or ECG changes Cardiac nuclear scan studies diagnostic of CAD, e.g., thallium scan or ECHO with stress or pharmacologic interventions (adenosine, dipyridamole, etc.) Stable treatment with one of the following antianginal medications for at least 4 weeks prior to Screening beta-blocker (atenolol up to 50 mg daily or metoprolol up to 100 mg daily) Inability to exercise or having exercise limitation due to other co-morbidities that may interfere with ability to perform required ETT (e.g., morbid obesity, significant chronic lung disease, prior hospitalization for acute exacerbation of chronic lung disease or home oxygen use, chronic oral steroid therapy that can limit exercise capacity, osteoarthritis, peripheral artery disease, etc.) Any absolute contraindication to ETT Presence of electrocardiographic or other abnormalities that interfere with ECG interpretation or may cause a false positive stress test (e.g., ≥ 1 mm horizontal or down-sloping ST segment depression at rest in any standard ECG lead, Lown-Ganong-Levine syndrome, Wolff-Parkinson-White syndrome, left bundle branch block, left ventricular hypertrophy with repolarization abnormality, ventricular pacemaker, etc.) Decompensated heart failure Clinically significant valvular heart disease or congenital cardiac defects Acute coronary syndrome in the prior 2 months or coronary revascularization within the prior 6 months or planned coronary revascularization during the study period Stroke or transient ischemic attack within 6 months prior to Screening History of serious ventricular dysrhythmias or a history of life-threatening ventricular arrhythmia Atrial fibrillation QTc > 0.5 seconds | 0 |
A 58-year-old African-American woman presents to the ER with episodic pressing/burning anterior chest pain that began two days earlier for the first time in her life. The pain started while she was walking, radiates to the back, and is accompanied by nausea, diaphoresis and mild dyspnea, but is not increased on inspiration. The latest episode of pain ended half an hour prior to her arrival. She is known to have hypertension and obesity. She denies smoking, diabetes, hypercholesterolemia, or a family history of heart disease. She currently takes no medications. Physical examination is normal. The EKG shows nonspecific changes. | eligible ages (years): 18.0-75.0, Asthma, Chronic Obstructive Pulmonary Disease (COPD) documented diagnosis of asthma or COPD in accordance with guidelines stable condition, defined as a disease without exacerbation for at least 1 month prior to study enrolment mean HR in holter ECG recording of ≥ 60 bpm disease exacerbation in previous month inability to understand instructions on study procedures | 0 |
A 58-year-old African-American woman presents to the ER with episodic pressing/burning anterior chest pain that began two days earlier for the first time in her life. The pain started while she was walking, radiates to the back, and is accompanied by nausea, diaphoresis and mild dyspnea, but is not increased on inspiration. The latest episode of pain ended half an hour prior to her arrival. She is known to have hypertension and obesity. She denies smoking, diabetes, hypercholesterolemia, or a family history of heart disease. She currently takes no medications. Physical examination is normal. The EKG shows nonspecific changes. | eligible ages (years): 25.0-65.0, Chronic Stable Angina Patients of chronic stable angina with abnormal Exercise Myocardial Perfusion Spect Scan with reversible and partially reversible ischemic changes Male and female Age 25 to 65 years Patient must understand and be willing, able and likely to comply with all study procedures and restrictions and comprehends the diary cards Patient must be able to give voluntary written informed consent Hypertension of > 170/100 mm of Hg Valvular heart disease and cardiomyopathy Myocardial infarction in < 6 months Unstable angina Congestive cardiac failure Severe anemia (Hb 7G/dl) Cardiac arrhythmias or II or III degree AV block Significant liver or renal dysfunction IDDM (Type-1 diabetes mellitus) Systolic blood pressure < 100 mm Hg | 1 |
A 58-year-old African-American woman presents to the ER with episodic pressing/burning anterior chest pain that began two days earlier for the first time in her life. The pain started while she was walking, radiates to the back, and is accompanied by nausea, diaphoresis and mild dyspnea, but is not increased on inspiration. The latest episode of pain ended half an hour prior to her arrival. She is known to have hypertension and obesity. She denies smoking, diabetes, hypercholesterolemia, or a family history of heart disease. She currently takes no medications. Physical examination is normal. The EKG shows nonspecific changes. | eligible ages (years): 21.0-999.0, Acute Myocardial Infarction Heart Attack Acute Coronary Syndrome Unstable Angina Acute myocardial infarction, acute coronary syndrome, unstable angina, men & women, all races & ethnicities age < 21 years | 1 |
A 58-year-old African-American woman presents to the ER with episodic pressing/burning anterior chest pain that began two days earlier for the first time in her life. The pain started while she was walking, radiates to the back, and is accompanied by nausea, diaphoresis and mild dyspnea, but is not increased on inspiration. The latest episode of pain ended half an hour prior to her arrival. She is known to have hypertension and obesity. She denies smoking, diabetes, hypercholesterolemia, or a family history of heart disease. She currently takes no medications. Physical examination is normal. The EKG shows nonspecific changes. | eligible ages (years): 18.0-50.0, Obesity Subject, male or female, is age 18 to 50 years of age Subject must be able to understand and be willing to sign an informed consent document Subject must be willing and able to participate in all aspects of the study and agree to comply with all study requirements for the duration of the study. This includes availability of reliable transportation and sufficient time to attend all follow-up visits Subject has a BMI of 40 or 30 to 39.9 plus one or more co-morbid diseases expected to improve with weight loss, including but not limited to hypertension, dyslipidemia, obstructive sleep apnea, or diabetes mellitus Subject must be fully ambulatory, without chronic reliance on walking aids such as crutches, walkers or a wheelchair Subject must be of sufficient and stable medical health, as evaluated by the Principal Investigator Subject must have a primary care physician that will manage the subject for any co-morbid conditions throughout the study Subject must have failed standard obesity therapy of diet, exercise, behavior modification, and pharmacologic agents either alone or in combination, as assessed by an interview with a member of the study team at baseline Subject agrees to refrain from any type of reconstructive surgery that may affect body weight such as mammoplasty or abdominal lipoplasty or liposuction, during the trial Subject has history of/or signs and/or symptoms of gastro-duodenal ulcer disease Subject has poorly controlled diabetes as indicated by the lack of stable diabetes medications and doses over the last month, or has a history of diabetes for greater than 10 years Subject has had significant weight loss in the last 3 months, or between baseline and the study procedure Subject has a history or is diagnosed with eating disorders Subject has history of peptic ulcer and tests positive for H. pylori, unless treated before the procedure Subject has symptomatic congestive heart failure, cardiac arrhythmia or unstable coronary artery disease Subject has pre-existing respiratory disease such as chronic obstructive pulmonary disease (COPD), pneumonia or cancer Subject has significant esophageal disease including Zenker's diverticulum, grade 3-4 reflux esophagitis, stricture, Barrett's esophagus, esophageal cancer, esophageal diverticulum, dysphagia, achalasia, or symptoms of dysmotility Subject is observed during EGD to have heavily scarred, malignant or poor quality/friable tissue in areas of the stomach where plications are to be placed | 1 |
A 58-year-old African-American woman presents to the ER with episodic pressing/burning anterior chest pain that began two days earlier for the first time in her life. The pain started while she was walking, radiates to the back, and is accompanied by nausea, diaphoresis and mild dyspnea, but is not increased on inspiration. The latest episode of pain ended half an hour prior to her arrival. She is known to have hypertension and obesity. She denies smoking, diabetes, hypercholesterolemia, or a family history of heart disease. She currently takes no medications. Physical examination is normal. The EKG shows nonspecific changes. | eligible ages (years): 25.0-50.0, Hypertension essential hypertension ACE inhibitors diabetes mellitus endocrinopathies no smokers | 0 |
A 58-year-old African-American woman presents to the ER with episodic pressing/burning anterior chest pain that began two days earlier for the first time in her life. The pain started while she was walking, radiates to the back, and is accompanied by nausea, diaphoresis and mild dyspnea, but is not increased on inspiration. The latest episode of pain ended half an hour prior to her arrival. She is known to have hypertension and obesity. She denies smoking, diabetes, hypercholesterolemia, or a family history of heart disease. She currently takes no medications. Physical examination is normal. The EKG shows nonspecific changes. | eligible ages (years): 18.0-999.0, Breast Cancer TRIAL Patient age 18 years or older who self-identifies as African-American In early survivorship phase, defined as being 1-12 months post completion of treatment for stage 0-3 breast cancer Receiving health care primarily through an health maintenance organization (HMO) Patients with metastatic cancer or a second primary cancer, because their medical characteristics (e.g. disease progression) are significantly different Breast cancer survivors (BCS) with other major disabling medical, psychiatric, or substance abuse conditions (e.g., anxiety, depression, alcohol/tobacco problems) will be excluded PEER At least 25 years of age who self-identifies as African-American Previously participated in any type of research study Has at least high school education | 0 |
A 58-year-old African-American woman presents to the ER with episodic pressing/burning anterior chest pain that began two days earlier for the first time in her life. The pain started while she was walking, radiates to the back, and is accompanied by nausea, diaphoresis and mild dyspnea, but is not increased on inspiration. The latest episode of pain ended half an hour prior to her arrival. She is known to have hypertension and obesity. She denies smoking, diabetes, hypercholesterolemia, or a family history of heart disease. She currently takes no medications. Physical examination is normal. The EKG shows nonspecific changes. | eligible ages (years): 20.0-999.0, Chronic Stable Angina Male or female aged > 20 Patients who had effort-induced angina which was relieved by rest or nitroglycerin, or who had catheterization-documented coronary artery disease or previous myocardial infarction ≥ 3 months before screening Patients who manifested positive ETT (exercise tolerance testing) (defined as ST-segment depression ≥ 1 mm compared with at rest, with or without limiting angina) at screening (Day -7) Patients who manifested positive ETT (exercise tolerance testing) (defined as ST-segment depression ≥ 1 mm compared with at rest, with or without limiting angina) on the day of enrollment (Day 0). ETT performance between Day -7 and Day 0 were required not differ by >20% in total exercise time Female patient who was in the post-menopausal stage or of childbearing potential who used adequate contraception since last menstruation and no plan for conception during the study was non-lactating had negative pregnancy test (urine) within 14 days prior to the study Able to provide written informed consent Patients with pre-excitation, conduction abnormalities, pacemaker rhythm, unstable angina or myocardial infarction within the preceding 3 months Patients with heart failure (New York Heart Association class III or IV), uncorrected valvular or congenital heart disease, patients who needed digoxin, isosorbide mononitrate, nitroglycerin sustained release preparation, theophylline, class I antiarrhythmic agents, digitalis, or monoamine oxidase inhibitors, as judged by the investigator Patients with any EKG abnormalities preventing the interpretation of ischemia (complete left bundle branch block) Patients with Chronic Obstructive Pulmonary Disease (COPD) requiring bronchodilators Patients with hepatic failure (defined as aspartate transaminase (AST) and/or alanine transaminase (ALT) > 3X the upper limit of normal values), and/or renal failure (defined as serum creatinine > 3 mg/dL) Patients with severe gastrointestinal illness as judged by the investigator Patient with any conditions that interfered the performance of exercise tolerance test as judged by investigator (e.g., knee/ankle arthropathy, Parkinsonism, stroke) | 0 |
A 58-year-old African-American woman presents to the ER with episodic pressing/burning anterior chest pain that began two days earlier for the first time in her life. The pain started while she was walking, radiates to the back, and is accompanied by nausea, diaphoresis and mild dyspnea, but is not increased on inspiration. The latest episode of pain ended half an hour prior to her arrival. She is known to have hypertension and obesity. She denies smoking, diabetes, hypercholesterolemia, or a family history of heart disease. She currently takes no medications. Physical examination is normal. The EKG shows nonspecific changes. | eligible ages (years): 18.0-75.0, Acute Coronary Syndrome Age 18 years Ischemic discomfort (ie, ischemic chest pain or equivalent) at rest ≥20 minutes within previous 24 hours Any (new, presumably new, or old) LBBB on the prehospital (ambulance) or admission ECG Urgent coronary angiography (followed, when indicated, by PCI), ideally within 90 minutes after admission all-comers design | 0 |
A 58-year-old African-American woman presents to the ER with episodic pressing/burning anterior chest pain that began two days earlier for the first time in her life. The pain started while she was walking, radiates to the back, and is accompanied by nausea, diaphoresis and mild dyspnea, but is not increased on inspiration. The latest episode of pain ended half an hour prior to her arrival. She is known to have hypertension and obesity. She denies smoking, diabetes, hypercholesterolemia, or a family history of heart disease. She currently takes no medications. Physical examination is normal. The EKG shows nonspecific changes. | eligible ages (years): 18.0-75.0, Angina Pectoris Myocardial Infarction Coronary Disease Myocardial Ischemia Acute Coronary Syndrome Patients affected by history of IHD with a non-fatal evolution(angina or AMI as first manifestation),age at the onset of the disease (<50 o >60 years Patients with acute coronary syndrome as first manifestation of coronary disease, admitted to the coronary unit within 6 hours from the onset of symptoms Age>75 Pregnancy Recent(< 6 months) cerebral ischemic attack Active cancer Inability to provide an informed consent | 0 |
A 58-year-old African-American woman presents to the ER with episodic pressing/burning anterior chest pain that began two days earlier for the first time in her life. The pain started while she was walking, radiates to the back, and is accompanied by nausea, diaphoresis and mild dyspnea, but is not increased on inspiration. The latest episode of pain ended half an hour prior to her arrival. She is known to have hypertension and obesity. She denies smoking, diabetes, hypercholesterolemia, or a family history of heart disease. She currently takes no medications. Physical examination is normal. The EKG shows nonspecific changes. | eligible ages (years): 18.0-65.0, Low Back Pain unilateral pain near the sacroiliac joint that does not extend pass the knee positive result on 2 of 6 sacroiliac joint provocation tests compression test distraction test posterior shear test Gaenslens' test (left and right) sacral thrust test current pregnancy or pregnancy in the last 6 months history of surgery to lumbar spine, pelvis, chest, abdomen history of congenital lumbar or pelvic anomalies any neurological signs in the lower extremity | 0 |
A 58-year-old African-American woman presents to the ER with episodic pressing/burning anterior chest pain that began two days earlier for the first time in her life. The pain started while she was walking, radiates to the back, and is accompanied by nausea, diaphoresis and mild dyspnea, but is not increased on inspiration. The latest episode of pain ended half an hour prior to her arrival. She is known to have hypertension and obesity. She denies smoking, diabetes, hypercholesterolemia, or a family history of heart disease. She currently takes no medications. Physical examination is normal. The EKG shows nonspecific changes. | eligible ages (years): 18.0-999.0, Primary Open Angle Glaucoma Diagnosis of POAG Documented glaucomatous VF damage with mean defect (MD) > 3 dB Progressing glaucomatous damage justifying a DSCI Aged ≥18 years, of either sex Not more than 4 diopters spherical equivalent on the study eye Not more than 2 diopters cylinder equivalent on the study eye Have given written informed consent, prior to any investigational procedures Corneal or conjunctival abnormality precluding contact lens adaptation Severe dry eye syndrome Patients with allergy to corneal anesthetic Patients with contraindications for silicone contact lens wear Patients not able to understand the character and individual consequences of the investigation Participation in other clinical research within the last 4 weeks | 0 |
A 58-year-old African-American woman presents to the ER with episodic pressing/burning anterior chest pain that began two days earlier for the first time in her life. The pain started while she was walking, radiates to the back, and is accompanied by nausea, diaphoresis and mild dyspnea, but is not increased on inspiration. The latest episode of pain ended half an hour prior to her arrival. She is known to have hypertension and obesity. She denies smoking, diabetes, hypercholesterolemia, or a family history of heart disease. She currently takes no medications. Physical examination is normal. The EKG shows nonspecific changes. | eligible ages (years): 18.0-45.0, LUMBAR BACK PAIN PELVIC PAIN PREGNANCY Lower back pain and / or posterior pelvic pain when completing the interview. Gestational age greater than or equal to 12 weeks Twin pregnancy. Medical restrictions on the exercise. Be doing physical therapy for the symptom of back pain and / or posterior pelvic | 0 |
A 58-year-old African-American woman presents to the ER with episodic pressing/burning anterior chest pain that began two days earlier for the first time in her life. The pain started while she was walking, radiates to the back, and is accompanied by nausea, diaphoresis and mild dyspnea, but is not increased on inspiration. The latest episode of pain ended half an hour prior to her arrival. She is known to have hypertension and obesity. She denies smoking, diabetes, hypercholesterolemia, or a family history of heart disease. She currently takes no medications. Physical examination is normal. The EKG shows nonspecific changes. | eligible ages (years): 18.0-999.0, Inappropriate Sinus Tachycardia Inappropriate sinus tachycardia (HR >100 bpm at rest ECG and/or medium Holter ECG HR >90 bpm) Age > 18 years Secondary causes of sinus tachycardia Structural heart diseases Postural orthostatic tachycardia syndrome Sinus nodal reentrant tachycardia Contraindications to beta-blockers Administration of beta-blockers, non-di-hydropiridinic calcium channels antagonists, class I and III anti-arrhythmic drugs or digitalis at the time of enrollment Age < 18 years Inability of giving informed consent | 0 |
A 58-year-old African-American woman presents to the ER with episodic pressing/burning anterior chest pain that began two days earlier for the first time in her life. The pain started while she was walking, radiates to the back, and is accompanied by nausea, diaphoresis and mild dyspnea, but is not increased on inspiration. The latest episode of pain ended half an hour prior to her arrival. She is known to have hypertension and obesity. She denies smoking, diabetes, hypercholesterolemia, or a family history of heart disease. She currently takes no medications. Physical examination is normal. The EKG shows nonspecific changes. | eligible ages (years): 18.0-75.0, Metastatic Breast Cancer age>=18years Eastern Cooperative Oncology Group (ECOG) performance status (PS) <=2 and a life expectancy >= 12 weeks histological-proven, HER-2 negative measurable stage IV disease exposure to anthracyclines, taxanes either in the neoadjuvant/adjuvant or in the metastatic setting and had documented disease progression after the firstline or secondline treatment Patients previously treated with radiotherapy were eligible for the study, provided that measurable disease existed outside the radiation field At least 3 weeks from the prior chemotherapy or radiotherapy. At least 2 weeks from the prior endocrine therapy Patients with active infection or other serious underlying medical conditions Patients had prior treatment with 5-FU infusion and/or oxaliplatin therapy Inadequate bone marrow, liver, renal, medullary, and cardiac functions Evidence of spinal cord compression or brain metastasis History of another malignancy within the last five years except cured basal cell carcinoma of skin and carcinoma in-situ of uterine cervix or a contralateral breast cancer Pregnant or lactating women Serious uncontrolled intercurrent infection History or evidence of inherited bleeding diathesis or coagulopathy with the risk of bleeding Serious non-bleeding wound, peptic ulcer or bone fracture Prior dihypopyrimidine dehydrogenase deficiency | 0 |
A 58-year-old African-American woman presents to the ER with episodic pressing/burning anterior chest pain that began two days earlier for the first time in her life. The pain started while she was walking, radiates to the back, and is accompanied by nausea, diaphoresis and mild dyspnea, but is not increased on inspiration. The latest episode of pain ended half an hour prior to her arrival. She is known to have hypertension and obesity. She denies smoking, diabetes, hypercholesterolemia, or a family history of heart disease. She currently takes no medications. Physical examination is normal. The EKG shows nonspecific changes. | eligible ages (years): 40.0-80.0, Coronary Disease non-acute chest pain those who underwent CT calcium scoring availability of all relevant risk factor information previous coronary disease i.e., myocardial infarction or revascularization | 1 |
A 58-year-old African-American woman presents to the ER with episodic pressing/burning anterior chest pain that began two days earlier for the first time in her life. The pain started while she was walking, radiates to the back, and is accompanied by nausea, diaphoresis and mild dyspnea, but is not increased on inspiration. The latest episode of pain ended half an hour prior to her arrival. She is known to have hypertension and obesity. She denies smoking, diabetes, hypercholesterolemia, or a family history of heart disease. She currently takes no medications. Physical examination is normal. The EKG shows nonspecific changes. | eligible ages (years): 18.0-60.0, Kidney Calculi Well functioning kidney (serum creatinine <1.2 mg/dl) Solitary renal stone Size: 25 mm or less in the largest diameter Contraindications to ESWL Previous surgical treatment of renal stones Congenital renal anomalies Pediatric patients (age <18 years) Patients with Diabetes or hypertension | 0 |
A 58-year-old African-American woman presents to the ER with episodic pressing/burning anterior chest pain that began two days earlier for the first time in her life. The pain started while she was walking, radiates to the back, and is accompanied by nausea, diaphoresis and mild dyspnea, but is not increased on inspiration. The latest episode of pain ended half an hour prior to her arrival. She is known to have hypertension and obesity. She denies smoking, diabetes, hypercholesterolemia, or a family history of heart disease. She currently takes no medications. Physical examination is normal. The EKG shows nonspecific changes. | eligible ages (years): 18.0-85.0, Hypertension Diagnosis of severe hypertension must be made on the basis of current findings, medical history, and physical examination Any serious medical condition that may adversely affect the patient's safety, limit the subject's ability to participate in the study, comply with follow-up requirements or impact the scientific integrity of the study | 1 |
A 58-year-old African-American woman presents to the ER with episodic pressing/burning anterior chest pain that began two days earlier for the first time in her life. The pain started while she was walking, radiates to the back, and is accompanied by nausea, diaphoresis and mild dyspnea, but is not increased on inspiration. The latest episode of pain ended half an hour prior to her arrival. She is known to have hypertension and obesity. She denies smoking, diabetes, hypercholesterolemia, or a family history of heart disease. She currently takes no medications. Physical examination is normal. The EKG shows nonspecific changes. | eligible ages (years): 18.0-50.0, Pregnancy Related Anaesthesia Viable, singleton pregnancy ≥ 37 weeks gestation undergoing EL LSCS Low risk for post-partum hemorrhage, such as no proven abruptio placentae, placenta previa, multiple pregnancy, pre-eclampsia / gestational hypertension, previous PPH, obesity (based on BMI pre pregnancy which is ≥ 30 kg/m2), big baby Ability to provide informed consent Emergency caesarean section Preterm Labour Grandmultipara Multiple Pregnancy Placenta Previa Previous PPH Maternal Obesity ( BMI pre pregnancy ≥ 30 kg/m2)) Have co-morbidity illness such as hypertension/pre-eclampsia, established cardiac diseases, history or evidence of liver, renal, vascular, or endocrine disease and bleeding disorder Contraindication to carbetocin and oxytocin Language Barrier | 0 |
A 58-year-old African-American woman presents to the ER with episodic pressing/burning anterior chest pain that began two days earlier for the first time in her life. The pain started while she was walking, radiates to the back, and is accompanied by nausea, diaphoresis and mild dyspnea, but is not increased on inspiration. The latest episode of pain ended half an hour prior to her arrival. She is known to have hypertension and obesity. She denies smoking, diabetes, hypercholesterolemia, or a family history of heart disease. She currently takes no medications. Physical examination is normal. The EKG shows nonspecific changes. | eligible ages (years): 45.0-75.0, Ischemic Heart Disease Obesity Stable Ischemic Heart Disease BMI 28 kg/m2 Known Diabetes Mellitus Repeated Fasting plasma glucose ≥ 7 mmol/L or Hba1c > 7 % Severe or moderate valve disease Main stem stenosis Severe heart failure, Ejection Fraction < 35 % Physical or mental disability which are expected to prevent completion of intervention Severe Chronic obstructive Pulmonary Disease (COPD) (FEV1 < 50 % of expected) or asthma Active cancer Severe kidney (GFR < 40 ml/hour) or severe liver disease Severe ischemia or arrhythmias during exercise test | 2 |
A 58-year-old African-American woman presents to the ER with episodic pressing/burning anterior chest pain that began two days earlier for the first time in her life. The pain started while she was walking, radiates to the back, and is accompanied by nausea, diaphoresis and mild dyspnea, but is not increased on inspiration. The latest episode of pain ended half an hour prior to her arrival. She is known to have hypertension and obesity. She denies smoking, diabetes, hypercholesterolemia, or a family history of heart disease. She currently takes no medications. Physical examination is normal. The EKG shows nonspecific changes. | eligible ages (years): 16.0-999.0, Chest Pain All patients over the age of 18 years presenting with the leading symptom of first time or recurrent acute chest pain in the emergency room of the Department of Internal Medicine, University Hospital of Zurich Missing informed consent Cardiopulmonary unstable patients No self reported chest pain Recent thoracic surgery within1 year, inflammatory joint disease, fibromyalgia, cardiogenic shock | 0 |
A 58-year-old African-American woman presents to the ER with episodic pressing/burning anterior chest pain that began two days earlier for the first time in her life. The pain started while she was walking, radiates to the back, and is accompanied by nausea, diaphoresis and mild dyspnea, but is not increased on inspiration. The latest episode of pain ended half an hour prior to her arrival. She is known to have hypertension and obesity. She denies smoking, diabetes, hypercholesterolemia, or a family history of heart disease. She currently takes no medications. Physical examination is normal. The EKG shows nonspecific changes. | eligible ages (years): 10.0-50.0, Breast Cancer Any woman who identifies as African American, Black, or African Currently nursing a baby Able and willing to sign written informed consent Willing to be contacted by study personnel for follow-up to determine whether a biopsy took place Willing to have her milk sample archived for future analyses The woman does not consider herself to be of African American, Black, or African. These women may participate in the other ongoing Breast Milk Study at University of Massachusetts Unable to sign written Informed Consent or Assent Form Unwilling to be contacted by study personnel | 0 |
A 58-year-old African-American woman presents to the ER with episodic pressing/burning anterior chest pain that began two days earlier for the first time in her life. The pain started while she was walking, radiates to the back, and is accompanied by nausea, diaphoresis and mild dyspnea, but is not increased on inspiration. The latest episode of pain ended half an hour prior to her arrival. She is known to have hypertension and obesity. She denies smoking, diabetes, hypercholesterolemia, or a family history of heart disease. She currently takes no medications. Physical examination is normal. The EKG shows nonspecific changes. | eligible ages (years): 18.0-65.0, Episodic Tension-Type Headache Male and female patients from 18 years onwards History of ETTH for at least one year. The number of days with such a headache is ≥2 per month Onset of TTH below 65 years of age At least 10 previous headache attacks fulfilling the following four Patients with headache attacks lasting from 30 minutes to 7 days At least two of the following pain characteristics are present Pressing or tightening (non-pulsating) quality Intensity of pain: moderate = unable to ignore (pain may inhibit, but does not prohibit activities) Bilateral location No aggravation by walking stairs or similar routine physical activity Headaches other than TTH: (e.g. migraine, cluster headache, hypertension headache, drug-related headache,analgesic-induced headache,post-traumatic headache; associated migraine attacks are permitted if they are well recognized by the patient and if their frequency during the preceding year has not exceeded one per month) Presence of oromandibular dysfunction History of facial or cranial surgery Use of prophylactic drugs for headache within one month prior to enrolment Use of drugs for acute TTH treatment for ≥ 10 days of headache per month Anticipated problems in adhering to the self-observation procedure (e.g. because of work) Abuse of alcohol, narcotics or other drugs Serious illnesses within the last 3 months (e.g. myocardial infarction, cardiac insufficiency NYHA III and IV, low blood pressure, cerebral insult, diabetes mellitus, neuropathy, changes in the skin or neoplasms in the head) Epilepsy Intake of anti-psychotic, anti-depressant or anti-epileptic medication during the previous month | 0 |
A 58-year-old African-American woman presents to the ER with episodic pressing/burning anterior chest pain that began two days earlier for the first time in her life. The pain started while she was walking, radiates to the back, and is accompanied by nausea, diaphoresis and mild dyspnea, but is not increased on inspiration. The latest episode of pain ended half an hour prior to her arrival. She is known to have hypertension and obesity. She denies smoking, diabetes, hypercholesterolemia, or a family history of heart disease. She currently takes no medications. Physical examination is normal. The EKG shows nonspecific changes. | eligible ages (years): 18.0-999.0, Acute Coronary Syndrome Female (post menopausal or surgically sterile) and/or male aged 18 years or older Presenting with ACS fulfilling the following Symptoms or new ECG changes (ST segment elevation or depression of at least 1 mm in 2 or more contiguous leads on EKG) Elevation of biomarkers (CK-MB ≥2 ULN or troponin ≥ ULN) Self-identified as African-American Treatment with 75-100mg ASA daily Any indication (atrial fibrillation, mitral stenosis or prosthetic heart valve, PE, DVT) for antithrombotic treatment during study period Fibrinolytic therapy within 48 hours before randomization Concomitant therapy with a drug having possible interaction with ticagrelor. (concomitant therapy with a strong cytochrome P-450 3A inhibitor or inducer) Increased bleeding risk including: recent (<30 days) GI bleeding, any history of intracranial, intraocular, retroperitoneal, or spinal bleeding, recent (<30 days of dosing) major trauma, sustained uncontrolled hypertension (systolic blood pressure [SBP]>180mmHg or diastolic blood pressure [DBP]>100mmHg), history of hemorrhagic disorders that can increase the risk of bleeding, platelet count less than 100,000 mm3 or hemoglobin <10 g/dL Any history of hemorrhagic stroke Contraindication or other reason that ASA or ticagrelor should not be administered (e.g., hypersensitivity, active bleeding, major surgery within 30 days of dosing) Severe renal failure (creatinine clearance <30mL/min or patient requires dialysis) History of moderate or severe hepatic impairment with aspartate amino transferace, alanine amino transferase or total bilirubin > 1.5 x upper limit of the reference range Pregnant or lactating women Patients receiving any glycoprotein IIb/IIIa inhibitors <8 hours before platelet reactivity testing | 1 |
A 58-year-old African-American woman presents to the ER with episodic pressing/burning anterior chest pain that began two days earlier for the first time in her life. The pain started while she was walking, radiates to the back, and is accompanied by nausea, diaphoresis and mild dyspnea, but is not increased on inspiration. The latest episode of pain ended half an hour prior to her arrival. She is known to have hypertension and obesity. She denies smoking, diabetes, hypercholesterolemia, or a family history of heart disease. She currently takes no medications. Physical examination is normal. The EKG shows nonspecific changes. | eligible ages (years): 18.0-999.0, Back Pain Low Back Pain Neuropathic Pain Informed consent signed Male or female 18 years of age or older Women of childbearing potential must have a negative pregnancy test at the Enrollment Visit Women of childbearing potential must practice medically acceptable methods of birth control during the trial Participant must be appropriately communicative and able to differentiate with regard to location and intensity of the pain, and to complete the questionnaires used in this trial Participants must have a diagnosis of chronic low back pain; chronic pain defined as pain lasting for at least 3 months prior to enrollment Participant's pain must require a strong analgesic (defined as World Health Organization Step III) as judged by the investigator Participants who require a washout of co-analgesics at enrolment must have an average pain score (NRS-3) of 5 points or higher. Participants who do not require a washout of co-analgesics at enrollment must have an average pain intensity score (NRS-3) during the last 3 days of 6 points or higher The painDETECT diagnostic screening questionnaire must be either "positive" (score of 19 to 38 inclusive) or "unclear" (score of 13 to 18 inclusive). If the participant is being treated with a stable regimen of centrally acting co-analgesics, a "negative" painDETECT score (score 9 points or higher) prior to allocation to treatment Presence of a clinically significant disease or clinical laboratory values that in the investigator's opinion may affect effectiveness, quality of life, or safety/tolerability assessments Presence of active systemic or local infections that may, in the opinion of the investigator, affect the effectiveness, quality of life, or safety/tolerability assessments Employees of the investigator or trial site, with direct involvement in this trial or other trials under the direction of the investigator or trial site, as well as family members of employees of the investigator Participation in another trial concurrently, or within 4 weeks prior to the Enrollment Visit Known to or suspected of not being able to comply with the protocol and/or appropriate use of the Investigational Medicinal Products Any painful procedures (e.g., major surgery) scheduled during the trial duration (Enrollment Visit until Final Evaluation Visit) that may, in the opinion of the investigator, affect the effectiveness, quality of life, or safety assessments Pending litigation or application for insurance/governmental benefits due to chronic pain or disability and/or if the granted benefits might be influenced by a successful participation in the trial Low back pain caused by cancer and/or metastatic diseases History of alcohol or drug abuse, or suspicion thereof in the investigator's judgment Presence of concomitant autoimmune inflammatory conditions | 0 |
A 58-year-old African-American woman presents to the ER with episodic pressing/burning anterior chest pain that began two days earlier for the first time in her life. The pain started while she was walking, radiates to the back, and is accompanied by nausea, diaphoresis and mild dyspnea, but is not increased on inspiration. The latest episode of pain ended half an hour prior to her arrival. She is known to have hypertension and obesity. She denies smoking, diabetes, hypercholesterolemia, or a family history of heart disease. She currently takes no medications. Physical examination is normal. The EKG shows nonspecific changes. | eligible ages (years): 18.0-80.0, Pulmonary Arterial Hypertension Signed informed consent prior to any study-mandated procedure Patients with PAH who completed study AC-055-401 Women of childbearing potential must Have a negative urine pregnancy test at Visit 1 and agree to perform monthly serum pregnancy tests Agree to use two methods of contraception from Visit 1 until 1 month after study drug discontinuation Patients who prematurely discontinued study drug in study AC-055-401 Females who are lactating or pregnant (positive Visit 1 pregnancy test) or plan to become pregnant during the study Known hypersensitivity to macitentan or its excipients or drugs of the same class | 0 |
A 58-year-old African-American woman presents to the ER with episodic pressing/burning anterior chest pain that began two days earlier for the first time in her life. The pain started while she was walking, radiates to the back, and is accompanied by nausea, diaphoresis and mild dyspnea, but is not increased on inspiration. The latest episode of pain ended half an hour prior to her arrival. She is known to have hypertension and obesity. She denies smoking, diabetes, hypercholesterolemia, or a family history of heart disease. She currently takes no medications. Physical examination is normal. The EKG shows nonspecific changes. | eligible ages (years): 40.0-70.0, Left Ventriclar Mass They had to have normal glucose tolerance They had to have either angiographically documented coronary artery disease or a previous history of myocardial infarction They were required to have an office BP < 130/80 mm Hg The presence of LVH on echocardiography (American Society of Echocardiography LVM index [LVMI] > 115 g/m2 for men and > 95 g/m2 for women) They were currently prescribed metformin They had renal and liver dysfunction, heart failure, or malignancy, or were unable to give informed consent Patients with contraindications to cardiac magnetic resonance (CMR) (pacemakers, claustrophobia) were also excluded, as were pregnant or lactating women | 0 |
A 58-year-old African-American woman presents to the ER with episodic pressing/burning anterior chest pain that began two days earlier for the first time in her life. The pain started while she was walking, radiates to the back, and is accompanied by nausea, diaphoresis and mild dyspnea, but is not increased on inspiration. The latest episode of pain ended half an hour prior to her arrival. She is known to have hypertension and obesity. She denies smoking, diabetes, hypercholesterolemia, or a family history of heart disease. She currently takes no medications. Physical examination is normal. The EKG shows nonspecific changes. | eligible ages (years): 18.0-70.0, Primary Hypertension Hypertension, Resistant to Conventional Therapy Essential hypertension subjects, aged 18-70 years, blood pressure > 140/90 mm Hg even used to be on 3 or more medications for a month and diagnosed as Phlegm and Stasis Syndrome will be included Patients will be excluded for the following conditions: with secondary resistant hypertension because of other disease like renal disease or pheochromocytoma; included in other clinical trial in one month; pregnant or breast-feed or preparing for pregnancy female; combined with disease like stroke, coronary atherosclerotic heart disease, diabetes, chronic renal failure or mental disease | 0 |
A 58-year-old African-American woman presents to the ER with episodic pressing/burning anterior chest pain that began two days earlier for the first time in her life. The pain started while she was walking, radiates to the back, and is accompanied by nausea, diaphoresis and mild dyspnea, but is not increased on inspiration. The latest episode of pain ended half an hour prior to her arrival. She is known to have hypertension and obesity. She denies smoking, diabetes, hypercholesterolemia, or a family history of heart disease. She currently takes no medications. Physical examination is normal. The EKG shows nonspecific changes. | eligible ages (years): 18.0-999.0, Acute Coronary Syndrome Provision of subject informed consent Patients hospitalized and diagnosed with STEMI or Hospitalized within 24 hours of onset of symptoms or transferred from another hospital within 24 hours of the onset of symptoms STEMI and precipitated by or as a complication of surgery, trauma, or GI bleeding or post-PCI STEMI and occurring in patients already hospitalized for other reasons Presence of any condition/circumstance which in the opinion of the investigator could significantly limit the complete follow up of the patient (e.g. tourist, non-native speaker or does not understand the local language, psychiatric disturbances) | 1 |
A 58-year-old African-American woman presents to the ER with episodic pressing/burning anterior chest pain that began two days earlier for the first time in her life. The pain started while she was walking, radiates to the back, and is accompanied by nausea, diaphoresis and mild dyspnea, but is not increased on inspiration. The latest episode of pain ended half an hour prior to her arrival. She is known to have hypertension and obesity. She denies smoking, diabetes, hypercholesterolemia, or a family history of heart disease. She currently takes no medications. Physical examination is normal. The EKG shows nonspecific changes. | eligible ages (years): 12.0-24.0, Obesity ≥ 12 years old Body image concerns Sub-threshold Eating disorder symptomatology Overweight but not obese (BMI between the 85th and 95th percentile for children/adolescents and BMI between 25 and 30 kg/m2 for adults 21-24) Be able to commit to weekly 1-hour sessions for six weeks and 3 separate assessment visits to the MSAHC Current eating disorder (anorexia nervosa, bulimia nervosa or binge eating disorder) absence of body image concerns normal or obese body weight (< 85th or ≥ 95th BMI percentile) | 0 |
A 58-year-old African-American woman presents to the ER with episodic pressing/burning anterior chest pain that began two days earlier for the first time in her life. The pain started while she was walking, radiates to the back, and is accompanied by nausea, diaphoresis and mild dyspnea, but is not increased on inspiration. The latest episode of pain ended half an hour prior to her arrival. She is known to have hypertension and obesity. She denies smoking, diabetes, hypercholesterolemia, or a family history of heart disease. She currently takes no medications. Physical examination is normal. The EKG shows nonspecific changes. | eligible ages (years): 18.0-75.0, Chest Pain patients undergoing removal of a chest tube after lung surgery patients able to indicate the pain score pregnancy, lactation insulin-dependent diabetes with dysautonomia central or peripheral neurological disease, agitation inability to understand the protocol inability to use the Pain Monitor: skin abnormalities at the site of measurement, pacemaker or implantable defibrillator, condition affecting the sympathetic nervous system, tremor of the extremities contra-indication to oral morphine respiratory failure, severe hepatic insufficiency, intracranial hypertension, epilepsy associations recent administration of neostigmine or of atropine | 0 |
A 58-year-old African-American woman presents to the ER with episodic pressing/burning anterior chest pain that began two days earlier for the first time in her life. The pain started while she was walking, radiates to the back, and is accompanied by nausea, diaphoresis and mild dyspnea, but is not increased on inspiration. The latest episode of pain ended half an hour prior to her arrival. She is known to have hypertension and obesity. She denies smoking, diabetes, hypercholesterolemia, or a family history of heart disease. She currently takes no medications. Physical examination is normal. The EKG shows nonspecific changes. | eligible ages (years): 30.0-65.0, Ischemic Heart Disease healthy men and women aged 30 to 65 years who has one or more self-assessed ischemic heart disease risk factors at screening: physical inactivity, overweight or obese (BMI ≥ 25/m2 ), waist circumference (≥ 80 cm for women, ≥ 94 cm for men). In addition, the participants should have the motivation and willingness to be randomized to any of the three groups, and to do their best to follow the given protocol no internet access or no access to a computer, smoking, pregnancy, or breast-feeding or planning to become pregnant within the next 12 months, a history of cardiovascular disease, type 2 diabetes, chronic disease / disorders that may affect the results of the study, substance abuse within the past 12 months, regular alcohol consumption > 21 units / week for men or > 14 units/ week for women, allergy or intolerance to food groups in the dietary guidelines, supplements with mega doses of nutrients that can have potential impact on ischemic heart disease risk markers (eg . fish oils) | 1 |
A 58-year-old African-American woman presents to the ER with episodic pressing/burning anterior chest pain that began two days earlier for the first time in her life. The pain started while she was walking, radiates to the back, and is accompanied by nausea, diaphoresis and mild dyspnea, but is not increased on inspiration. The latest episode of pain ended half an hour prior to her arrival. She is known to have hypertension and obesity. She denies smoking, diabetes, hypercholesterolemia, or a family history of heart disease. She currently takes no medications. Physical examination is normal. The EKG shows nonspecific changes. | eligible ages (years): 18.0-40.0, Obesity Live in Ribeirão Preto, São Paulo Brazil Age between 18 and 40 years old Female gender Regular menses Weight inferior than 120 Kg and body mass index (BMI) between 30 and 40 kg/m2, for the group with obesity BMI between 18,5 and 24,9 kg/m2, for the group without obesity High blood pressure, diabetes, glucose intolerance or impaired fasting glycemia, metabolic syndrome, hypothyroidism and any kidney, liver, heart or neurologic disease Psychiatric disorders, alcoholism, smoking or illicit drug abuse Pregnancy or desire to be pregnant Use of medications, excluding contraceptives Contraindication for magnetic resonance imaging Be in treatment for obesity | 0 |
A 58-year-old African-American woman presents to the ER with episodic pressing/burning anterior chest pain that began two days earlier for the first time in her life. The pain started while she was walking, radiates to the back, and is accompanied by nausea, diaphoresis and mild dyspnea, but is not increased on inspiration. The latest episode of pain ended half an hour prior to her arrival. She is known to have hypertension and obesity. She denies smoking, diabetes, hypercholesterolemia, or a family history of heart disease. She currently takes no medications. Physical examination is normal. The EKG shows nonspecific changes. | eligible ages (years): 18.0-999.0, Chronic Stable Angina Patients aged 18 and over with chronic stable angina (≥2 months duration) Following screening visit A positive exercise ECG (1mmSTD at J+0.08 seconds) on a modified Bruce protocol treadmill exercise test A positive dobutamine stress echocardiogram and/or a positive myocardial perfusion scan (MPI) and/or a positive coronary angiogram Unable to do exercise test Women of child bearing potential If of a racial origin at risk of glucose-6-phosphate dehydrogenase (G6PD) deficiency, G6PD will be excluded prior to in the study Resting STD>=1mm NYHA 3 or 4 HF or LVEF<45% Myocardial infarction or revascularisation within the last two months Left bundle branch block (LBBB) | 0 |
A 58-year-old African-American woman presents to the ER with episodic pressing/burning anterior chest pain that began two days earlier for the first time in her life. The pain started while she was walking, radiates to the back, and is accompanied by nausea, diaphoresis and mild dyspnea, but is not increased on inspiration. The latest episode of pain ended half an hour prior to her arrival. She is known to have hypertension and obesity. She denies smoking, diabetes, hypercholesterolemia, or a family history of heart disease. She currently takes no medications. Physical examination is normal. The EKG shows nonspecific changes. | eligible ages (years): 18.0-999.0, Obesity Intra-Abdominal Hypertension years or older Requiring intubation and mechanical ventilation BMI≥40 kg/m2 or IAP≥12 mmHg Known presence esophageal varices Recent esophageal trauma or surgery Severe thrombocytopenia (PTL≤10,000/mm3) Severe coagulopathy (INR≥2) Presence of pneumothorax Pregnancy Patients with diagnosed moderate to severe ARDS or with poor oxygenation index (PaO2/FiO2 < 200 mmHg) | 0 |
A 58-year-old African-American woman presents to the ER with episodic pressing/burning anterior chest pain that began two days earlier for the first time in her life. The pain started while she was walking, radiates to the back, and is accompanied by nausea, diaphoresis and mild dyspnea, but is not increased on inspiration. The latest episode of pain ended half an hour prior to her arrival. She is known to have hypertension and obesity. She denies smoking, diabetes, hypercholesterolemia, or a family history of heart disease. She currently takes no medications. Physical examination is normal. The EKG shows nonspecific changes. | eligible ages (years): 21.0-65.0, Obesity Subjects aged between 21 -65 years Subjects with BMI > 23 Kg/m2 Subjects aged between 21 -65 years Subjects with BMI > 23 Kg/m2 Diabetes (type 1 and type 2) Known or documented coronary heart disease (CHD) (including ECG consistent with prior myocardial infraction), cerebrovascular accident (including transient ischemic attack), peripheral vascular disease (including symptoms of claudication) Angina or other chest pain that may indicate CHD by history Clinically significant neoplastic, cardiovascular, hepatic, renal, metabolic, endocrine (untreated or unstable), or psychiatric (untreated or unstable) by history Medications: Lipid lowering therapy, daily NSAID or greater than 325 mg ASA (PRN use ok), clopidogrel (or equivalent), Coumadin, other investigational drugs within 30 days of study entry Pregnancy or planning pregnancy during the study period by history Uncontrolled hypertension Uncontrolled hypothyroidism | 1 |
A 58-year-old African-American woman presents to the ER with episodic pressing/burning anterior chest pain that began two days earlier for the first time in her life. The pain started while she was walking, radiates to the back, and is accompanied by nausea, diaphoresis and mild dyspnea, but is not increased on inspiration. The latest episode of pain ended half an hour prior to her arrival. She is known to have hypertension and obesity. She denies smoking, diabetes, hypercholesterolemia, or a family history of heart disease. She currently takes no medications. Physical examination is normal. The EKG shows nonspecific changes. | eligible ages (years): 0.0-999.0, Chronic Obstructive Pulmonary Disease Information consenting out-patients with a previous physician diagnosis of COPD Clinically stable Ambulatory Subjects who required supplemental oxygen for exercise Subjects with pulmonary hypertension and angina Intolerant to beetroot Insulin dependent diabetes Thyroid disease | 0 |
A 58-year-old African-American woman presents to the ER with episodic pressing/burning anterior chest pain that began two days earlier for the first time in her life. The pain started while she was walking, radiates to the back, and is accompanied by nausea, diaphoresis and mild dyspnea, but is not increased on inspiration. The latest episode of pain ended half an hour prior to her arrival. She is known to have hypertension and obesity. She denies smoking, diabetes, hypercholesterolemia, or a family history of heart disease. She currently takes no medications. Physical examination is normal. The EKG shows nonspecific changes. | eligible ages (years): 18.0-44.0, Domestic Violence Domestic Abuse Woman: African American/ African Caribbean/African heritage/Mixed Age 18 ‐ 44 (A.1) Abused (physical, sexual emotional abuse) by an intimate male partner based on responses to screening questions Has had an intimate male partner in the last 2 years Resident of the US Virgin Islands and plans to remain for next two years Woman: Not African American/African Caribbean or African Heritage/Mixed Under or over age limit No intimate partner in the last two years No history of physical, sexual or emotional abuse by an intimate partner Non resident of US Virgin Islands | 0 |
A 58-year-old African-American woman presents to the ER with episodic pressing/burning anterior chest pain that began two days earlier for the first time in her life. The pain started while she was walking, radiates to the back, and is accompanied by nausea, diaphoresis and mild dyspnea, but is not increased on inspiration. The latest episode of pain ended half an hour prior to her arrival. She is known to have hypertension and obesity. She denies smoking, diabetes, hypercholesterolemia, or a family history of heart disease. She currently takes no medications. Physical examination is normal. The EKG shows nonspecific changes. | eligible ages (years): 18.0-999.0, Intradialytic Hypotension Must be able to give informed consent for participation in this study Age ≥ 18 years A body weight > 100 lb or a body mass index > 18.5 End-stage renal disease with hemodialysis in-center three times per week Not missing any treatments in the preceding two weeks and in compliance with instructions from the health care provider In the last month had at least two episodes of IDH (defined as having hypotensive symptoms such as dizziness, fainting, headache, nausea, vomiting, cramping, weakness, blurry vision and/or a decrease in systolic blood pressure (SBP) of more than 20 mmHg) Hemoglobin greater than or equal to 9.0 g/dL (hematocrit 27%) to hemoglobin of 15.0 g/dL (hematocrit 45%) • Pregnancy (self-reported) Allergic to nylon, polyesters and latex Not able to understand the English language Not able to disengage the ACES from compression Having an excessively low systolic blood pressure (SBP which is less than 90 mmHg) Hemoglobin less than 9.0 g/dL or greater than 15 g/dL Excessive intra-abdominal fluid pressure Respiratory distress Bleeding in the chest and abdomen Bleeding dyscrasia causing serious coagulation problem | 0 |
A 58-year-old African-American woman presents to the ER with episodic pressing/burning anterior chest pain that began two days earlier for the first time in her life. The pain started while she was walking, radiates to the back, and is accompanied by nausea, diaphoresis and mild dyspnea, but is not increased on inspiration. The latest episode of pain ended half an hour prior to her arrival. She is known to have hypertension and obesity. She denies smoking, diabetes, hypercholesterolemia, or a family history of heart disease. She currently takes no medications. Physical examination is normal. The EKG shows nonspecific changes. | eligible ages (years): 18.0-999.0, Treatment of Acute Coronary Syndrome (ACS). The patient population that will be observed in the NIS must fulfil all of the following Female or male aged ≥18 years A patient information letter has been sent by the Investigator to the patient Patient discharged alive from this hospital to home following ACS (diagnosed with STEMI, or UA) ACS is either UA or myocardial infarction of Type 1 (spontaneous myocardial infarction related to ischemia due to a primary coronary event such as plaque erosion and/or rupture, fissuring, or dissection) ACS after 1st July 2012 and before 1st June 2013 Patient on ticagrelor, prasugrel or clopidogrel treatment at discharge following an ACS Patients will not be eligible to participate if any of the following are present Patient who participated in any interventional clinical study during the observation period Patient with ACS precipitated by or as complication of surgery, trauma, gastrointestinal bleeding or after Percutaneous Coronary Intervention (PCI) Patient with ACS occurring during a stay in the hospital | 0 |
A 58-year-old African-American woman presents to the ER with episodic pressing/burning anterior chest pain that began two days earlier for the first time in her life. The pain started while she was walking, radiates to the back, and is accompanied by nausea, diaphoresis and mild dyspnea, but is not increased on inspiration. The latest episode of pain ended half an hour prior to her arrival. She is known to have hypertension and obesity. She denies smoking, diabetes, hypercholesterolemia, or a family history of heart disease. She currently takes no medications. Physical examination is normal. The EKG shows nonspecific changes. | eligible ages (years): 18.0-999.0, Left Ventricular Hypertrophy Insulin Resistance Coronary Artery Disease Aged 18 years or over Participant willing and able to give informed consent Documented Ischaemic Heart Disease: either angio-graphically documented coronary artery disease or a previous history of myocardial infarction/angina Screening echocardiography based diagnosis of LVH based on ASE (males >115g/m2, females >95g/m2) Fasting insulin resistance index ≥ 2.7 AND/OR HbA1c >5.6 and less than 6.5 at screening Blood pressure < 140/85 mm Hg or 24hr BP <135/85 daytime average in screening Able (in the Investigators opinion) and willing to comply with all study requirements Cognitive impairment Type 1 or 2 Diabetes mellitus Chronic Heart Failure as evidenced by echocardiogram or documented diagnosis of CHF Left Ventricular Ejection Fraction <45% on screening echocardiography Contraindications to cardiac MRI (pacemakers, claustrophobia, metal implants, history of penetrative eye injury or exposure to metal fragments in eye requiring medical attention) Malignancy (receiving active treatment) or other life threatening disease, renal disease (CKD class 3B or worse) Pregnancy/lactating females Any other reason considered inappropriate by a study physician Participants who have participated in any other clinical trial within the previous 30 days | 0 |
A 58-year-old African-American woman presents to the ER with episodic pressing/burning anterior chest pain that began two days earlier for the first time in her life. The pain started while she was walking, radiates to the back, and is accompanied by nausea, diaphoresis and mild dyspnea, but is not increased on inspiration. The latest episode of pain ended half an hour prior to her arrival. She is known to have hypertension and obesity. She denies smoking, diabetes, hypercholesterolemia, or a family history of heart disease. She currently takes no medications. Physical examination is normal. The EKG shows nonspecific changes. | eligible ages (years): 18.0-80.0, Angina Pectoris Age 18 to 80 years History of stable, exertional angina pectoris (Canadian Cardiovascular Society functional class II to III) for at least 3 months duration prior to enrolment in the study Patients not currently receiving treatment with antianginal medication (other than short-acting nitrates) Between visits 2 and 3 two treadmill exercise tests, demonstrating ≥ 0.1 mV of horizontal or down sloping ST-segment depression, must be carried out. The difference in symptom-limited exercise duration between these two tests must not exceed 20% Total treadmill exercise duration > 3 minutes (i.e. stage 2 or above on a standard Bruce protocol) Coronary artery disease, preferably (not mandatory) documented by a history of proven myocardial infarction and/or coronary angiography indicating ≥ 50% reduction in luminal diameter of one or more coronary arteries or their primary branches Myocardial infarction within 3 months prior to enrolment in the study Percutaneous transluminal coronary angioplasty (PTCA) or coronary artery bypass surgery within 6 months Other types of angina (variant, unstable) Uncontrolled hypertension (systolic blood pressure > 180 mmHg or diastolic blood pressure > 100 mmHg) Resting heart rate < 50 bpm or > 100 bpm Significant valvular heart disease Heart failure New York Heart Association Class III or IV Chronic obstructive pulmonary disease and/or asthma with clinical symptoms requiring regular medication Significant arrhythmia (since this may interfere with the interpretation of the electrocardiogram) including Wolff Parkinson-White syndrome, atrial fibrillation, atrial flutter, sick sinus syndrome, significant Atrio-Ventricular heart block, intraventricular conduction defect (QRS > 0.12 seconds) ventricular pre-excitation, bundle branch block, the presence of a pace-maker, the presence of an implanted automatic defibrillator, uncorrected hypokalaemia (potassium < 3.5 mmol/litre) Insulin dependent diabetes mellitus | 0 |
A 58-year-old African-American woman presents to the ER with episodic pressing/burning anterior chest pain that began two days earlier for the first time in her life. The pain started while she was walking, radiates to the back, and is accompanied by nausea, diaphoresis and mild dyspnea, but is not increased on inspiration. The latest episode of pain ended half an hour prior to her arrival. She is known to have hypertension and obesity. She denies smoking, diabetes, hypercholesterolemia, or a family history of heart disease. She currently takes no medications. Physical examination is normal. The EKG shows nonspecific changes. | eligible ages (years): 18.0-60.0, Obesity Metabolic Syndrome Morbid obesity (BMI>30) patients with one of comorbidity (type 2 diabetes, dyslipidemia, or hypertension) Morbid obese patients (BMI>35) Prior bariatric surgery Malignancy (any type) End stage renal disease | 1 |
A 58-year-old African-American woman presents to the ER with episodic pressing/burning anterior chest pain that began two days earlier for the first time in her life. The pain started while she was walking, radiates to the back, and is accompanied by nausea, diaphoresis and mild dyspnea, but is not increased on inspiration. The latest episode of pain ended half an hour prior to her arrival. She is known to have hypertension and obesity. She denies smoking, diabetes, hypercholesterolemia, or a family history of heart disease. She currently takes no medications. Physical examination is normal. The EKG shows nonspecific changes. | eligible ages (years): 18.0-80.0, Hypertension Acute Myocardial Infarction Provision of informed consent prior to any study specific procedures Female and/or male aged 18-80 years Patients with ACS, i.e. STEMI, non-STEMI, treated with PCI Medical history of treated (ongoing) hypertension, or hypertension discovered at the time of ACS, and office SBP >140 despite treatment with three antihypertensive drugs Ejection fraction >40% Increased risk of pathological bleedings Office systolic blood pressure <120 Renal artery abnormalities eGFR <30 mL/min ICD or pacemaker, or any other metallic implant not compatible with MRI Estimated survival time <1 year Not oriented to person, place and time Inability to understand given information about the study Fertile female | 1 |
A 58-year-old African-American woman presents to the ER with episodic pressing/burning anterior chest pain that began two days earlier for the first time in her life. The pain started while she was walking, radiates to the back, and is accompanied by nausea, diaphoresis and mild dyspnea, but is not increased on inspiration. The latest episode of pain ended half an hour prior to her arrival. She is known to have hypertension and obesity. She denies smoking, diabetes, hypercholesterolemia, or a family history of heart disease. She currently takes no medications. Physical examination is normal. The EKG shows nonspecific changes. | eligible ages (years): 45.0-55.0, Hypertension Patients operated due to carpal tunnel syndrome under intravenous regional anesthesia betweem January 2009 and January 2010 The patients that the files could not be reached | 0 |
A 58-year-old African-American woman presents to the ER with episodic pressing/burning anterior chest pain that began two days earlier for the first time in her life. The pain started while she was walking, radiates to the back, and is accompanied by nausea, diaphoresis and mild dyspnea, but is not increased on inspiration. The latest episode of pain ended half an hour prior to her arrival. She is known to have hypertension and obesity. She denies smoking, diabetes, hypercholesterolemia, or a family history of heart disease. She currently takes no medications. Physical examination is normal. The EKG shows nonspecific changes. | eligible ages (years): 18.0-999.0, Atrial Fibrillation Caucasians ≥ 18 years of age History of typical or lone symptomatic AF AF symptoms present at least once per month ECG that was recorded within 12 months of randomization showing AF Starting a Class I or Class III AAD In sinus rhythm at enrollment Able to give informed consent Permanent AF or isolated atrial flutter Cardiac or thoracic surgery within the previous 6 months Previous use of amiodarone other than short-term use (e.g. for an acute arrhythmia in hospital) Medical condition that is likely to be fatal in less than one year Received 2 or more AADs in past Creatinine clearance <40 ml/min Contra-indication to a class I AAD e.g., structural heart disease, or history of MI Contra-indication to a class III AAD, e.g., congenital or acquired long QT syndrome with QTc>450 ms at baseline A reversible cause of AF (e.g., thyrotoxicosis) Previously treated with class I and class III antiarrhythmic drugs | 0 |
A 58-year-old African-American woman presents to the ER with episodic pressing/burning anterior chest pain that began two days earlier for the first time in her life. The pain started while she was walking, radiates to the back, and is accompanied by nausea, diaphoresis and mild dyspnea, but is not increased on inspiration. The latest episode of pain ended half an hour prior to her arrival. She is known to have hypertension and obesity. She denies smoking, diabetes, hypercholesterolemia, or a family history of heart disease. She currently takes no medications. Physical examination is normal. The EKG shows nonspecific changes. | eligible ages (years): 18.0-999.0, Acute Coronary Syndrome Women age 18 years or older Non-ST-elevation acute coronary syndrome (defined as new onset chest discomfort that occurs at rest or with low levels of activity/or emotion within the preceding 48 hours) with either elevated troponin T (≥ 0.03 ng per milliliter) elevated creatinine kinase MB-isoenzyme (≥ 5.0 ng per milliliter) elevated NT-pro-BNP (≥ 450 pg per milliliter) ST-segment depression (≥ 0.5 mm) or TIMI risk score (> 2) women who have elevated cardiac enzymes after non-cardiac surgery will also be considered ST-elevation myocardial infarction cardiogenic shock congestive heart failure hemodynamic instability use of fibrinolytic therapy in the last 96 hours current bleeding or bleeding disorder within the last 3 months that required transfusion pregnancy contraindication to any study medication. i.e.heparin, clopidogrel, or glycoprotein IIb/III inhibitor PCI in the last 6 months prior CABG | 1 |
A 58-year-old African-American woman presents to the ER with episodic pressing/burning anterior chest pain that began two days earlier for the first time in her life. The pain started while she was walking, radiates to the back, and is accompanied by nausea, diaphoresis and mild dyspnea, but is not increased on inspiration. The latest episode of pain ended half an hour prior to her arrival. She is known to have hypertension and obesity. She denies smoking, diabetes, hypercholesterolemia, or a family history of heart disease. She currently takes no medications. Physical examination is normal. The EKG shows nonspecific changes. | eligible ages (years): 18.0-50.0, Obesity for in main ACE stapling study Subject must be able to understand and be willing to sign an informed consent document Subject must be willing and able to participate in all aspects of the study and agree to comply with all study requirements for the duration of the study. This includes availability of reliable transportation and sufficient time to attend all follow-up visits Subject has a BMI of 40 or 30 to 39.9 plus one or more co-morbid diseases expected to improve with weight loss, including but not limited to hypertension, dyslipidemia, obstructive sleep apnea, or diabetes mellitus Subject must be fully ambulatory, without chronic reliance on walking aids such as crutches, walkers or a wheelchair Subject must be of sufficient and stable medical health, as evaluated by the Principal Investigator Subject must have a primary care physician that will manage the subject for any co-morbid conditions throughout the study Subject must have failed standard obesity therapy of diet, exercise, behaviour modification, and pharmacologic agents either alone or in combination, as assessed by an interview with a member of the study team at baseline Subject agrees to refrain from any type of reconstructive surgery that may affect body weight such as mammoplasty or abdominal lipoplasty or liposuction, during the trial Main study Subject has history of/or signs and/or symptoms of gastro-duodenal ulcer disease Subject has poorly controlled diabetes as indicated by the lack of stable diabetes medications and doses over the last month, or has a history of diabetes for greater than 10 years Subject has had significant weight loss in the last 3 months, or between baseline and the study procedure Subject has a history or is diagnosed with eating disorders Subject has history of peptic ulcer and tests positive for H. pylori, unless treated before the procedure Subject has symptomatic congestive heart failure, cardiac arrhythmia or unstable coronary artery disease Subject has pre-existing respiratory disease such as chronic obstructive pulmonary disease (COPD), pneumonia or cancer Subject has significant esophageal disease including Zenker's diverticulum, grade 3-4 reflux esophagitis, stricture, Barrett's esophagus, esophageal cancer, esophageal diverticulum, dysphagia, achalasia, or symptoms of dysmotility Subject is observed during EGD to have heavily scarred, malignant or poor quality/friable tissue in areas of the stomach where plications are to be placed | 2 |
A 58-year-old African-American woman presents to the ER with episodic pressing/burning anterior chest pain that began two days earlier for the first time in her life. The pain started while she was walking, radiates to the back, and is accompanied by nausea, diaphoresis and mild dyspnea, but is not increased on inspiration. The latest episode of pain ended half an hour prior to her arrival. She is known to have hypertension and obesity. She denies smoking, diabetes, hypercholesterolemia, or a family history of heart disease. She currently takes no medications. Physical examination is normal. The EKG shows nonspecific changes. | eligible ages (years): 18.0-999.0, Nerve; Disorder, Sympathetic Patients presenting for sympathetic block of the lower extremity (lumbar sympathetic block) Ages 18-99 Patients with pacemakers or cardiac defibrillators Age <18 IV sedation for anxiolysis or analgesia Burn patients or patients with severe dermatologic conditions (as defined by skin conditions causing further pain to patients that actively has to be treated) Allergy to adhesive tape Patient with diagnosis of: Dysautonomia, Sympathetic dysfunction (e.g.,Raynaud disease, Buerger disease) or Disorders of sweating (e.g.,Acquired idiopathic generalized anhidrosis) Patients on vasoactive drugs | 0 |
A 58-year-old African-American woman presents to the ER with episodic pressing/burning anterior chest pain that began two days earlier for the first time in her life. The pain started while she was walking, radiates to the back, and is accompanied by nausea, diaphoresis and mild dyspnea, but is not increased on inspiration. The latest episode of pain ended half an hour prior to her arrival. She is known to have hypertension and obesity. She denies smoking, diabetes, hypercholesterolemia, or a family history of heart disease. She currently takes no medications. Physical examination is normal. The EKG shows nonspecific changes. | eligible ages (years): 18.0-85.0, Postoperative Pain Patients undergoing unilateral THR and TKR who are between the ages of 18 and 85 regardless of the anesthesia and postoperative analgesia type Patients participating in other studies may participate in this study as well Patients with Motor Activity Assessment Scale (MAAS) Score of 3 and 4 Age <18, >85 History of chronic pain as defined by use of long acting opioid medication > 6 months duration MAAS Score of <3 and >4 Anticholinergic agent use Patients with the following conditions Autonomic neuropathy Pacemaker/AICD Burn patients or patients with severe dermatologic conditions (as defined by skin conditions causing further pain to patients that actively has to be treated) Allergy to adhesive tape Communication barriers | 0 |
A 58-year-old African-American woman presents to the ER with episodic pressing/burning anterior chest pain that began two days earlier for the first time in her life. The pain started while she was walking, radiates to the back, and is accompanied by nausea, diaphoresis and mild dyspnea, but is not increased on inspiration. The latest episode of pain ended half an hour prior to her arrival. She is known to have hypertension and obesity. She denies smoking, diabetes, hypercholesterolemia, or a family history of heart disease. She currently takes no medications. Physical examination is normal. The EKG shows nonspecific changes. | eligible ages (years): 18.0-50.0, Relapsing Remitting Multiple Sclerosis To be eligible to participate in this study, candidates must meet all the following atthe Screening visit (V0)AND at baseline (V1) Ability to understand the purpose and risks of the study and provide signed and dated informed consent and authorization to use protected information in accordance with local subject privacy regulations Patients with RRMS (McDonald 2010) who do not accept current injectable firstline DMTs Age between 18 and 50 years at the time of informed consent MS onset within one year before enrolment ≥ 1 Gd+ lesions at a brain MRI scan performed within three months beforeenrolment No previous disease modifying and/or immunosuppressive treatments for MS Must have a baseline EDSS between 0.0 and 5.0, inclusive. · Women of childbearing potential (i.e. who are not post-menopausal for at least 1 year) and men must practice effective contraception (as defined by the Investigator) during the study and be willing and able to continue contraception for 30 days after their last dose of study treatment Candidates will be excluded from study entry if any of the following exists at Screening OR Baseline/Randomization Visit Primary progressive, secondary progressive, or progressive relapsing MS, as defined by Lublin and Reingold (Lublin and Reingold 1996) Previous disease modifying and/or immunosuppressive treatments for MS, including Tcell or T-cell receptor vaccination, any therapeutic monoclonal antibody, Mitoxantrone, Cyclophosphamide Previous treatment with Fumaderm®, dimethyl fumarate or other fumarates History of malignancy (except basal cell carcinoma that has been completely excised prior to study enrollment) History of severe allergic or anaphylactic reactions or known drug hypersensitivity.Known allergy/hypersensitivity to Gadolinium History of abnormal laboratory results indicative of any significant endocrinologic, hematologic, hepatic, immunologic, metabolic, urologic, renal, and/or other major disease that in the opinion of the Investigator would preclude participation in a clinical trial Uncontrolled intercurrent illness including, but not limited to: ongoing or active infection; symptomatic congestive heart failure; unstable angina pectoris; cardiac arrhythmia; serious or acute liver, kidney, or bone marrow dysfunction; uncontrolled diabetes; serious or acute psychiatric illness that would limit compliance with study requirements History of or positive test result at screening for human immunodeficiency virus (HIV).Positive for hepatitis C antibody and/or positive for hepatitis B surface antigen (HBsAg) at screening | 0 |
A 58-year-old African-American woman presents to the ER with episodic pressing/burning anterior chest pain that began two days earlier for the first time in her life. The pain started while she was walking, radiates to the back, and is accompanied by nausea, diaphoresis and mild dyspnea, but is not increased on inspiration. The latest episode of pain ended half an hour prior to her arrival. She is known to have hypertension and obesity. She denies smoking, diabetes, hypercholesterolemia, or a family history of heart disease. She currently takes no medications. Physical examination is normal. The EKG shows nonspecific changes. | eligible ages (years): 18.0-999.0, Coronary Artery Disease Angina Symptoms of Angina Pectoris Angiographic evidence of epicardial coronary artery stenosis referred for PCI Flow limiting lesion (Fractional Flow Reserve ≤0.80) in one of following locations (as defined in trial89) Proximal or mid left anterior descending artery (LAD) Proximal or mid dominant right coronary artery (RCA) Proximal left circumflex artery (LCx) or 1ST Obtuse marginal Vessel Existing beta blocker prescription Echocardiogram performed within preceding 12 months Patient consent Previous myocardial infarction (MI) in target vessel myocardial territory or any MI in preceding 12 months (defined by patient history, ECG changes and evidence of regional wall motion abnormalities on echocardiography) FFR>0.80 in target vessel at time of procedure Requirement for Multi-vessel intervention in a single procedure Any chronic total occlusion (100% epicardial occlusion) on angiography Distal coronary artery stenosis or that affecting non-dominant RCA Heart Rate <60 bpm at (assessed by 12 lead ECG after minimum 10 minutes rest period) Any rhythm other than sinus rhythm Sick sinus syndrome or high grade atrio-ventricular block Permanent Pacemaker in situ Congenital QT Syndrome | 0 |
A 58-year-old African-American woman presents to the ER with episodic pressing/burning anterior chest pain that began two days earlier for the first time in her life. The pain started while she was walking, radiates to the back, and is accompanied by nausea, diaphoresis and mild dyspnea, but is not increased on inspiration. The latest episode of pain ended half an hour prior to her arrival. She is known to have hypertension and obesity. She denies smoking, diabetes, hypercholesterolemia, or a family history of heart disease. She currently takes no medications. Physical examination is normal. The EKG shows nonspecific changes. | eligible ages (years): 18.0-55.0, Overweight Obesity All participants will be between the ages of 18-55 meeting for overweight, with a BMI between 25 and 45 Participants will provide written informed consent for study participation Participants will possess English language skills at the 5th grade reading level Participants will be free of major medical conditions such as a recent history of coronary heart disease; recent history of myocardial infarction; recent symptoms of angina, diabetes, recent stroke, orthopedic problems that would limit activity during the following twelve months; or any other serious medical condition that would make physical activity unsafe Participants will not have bulimia or anorexia, significant cognitive impairment, a known psychotic disorder, or unstable psychiatric illness (e.g., recent psychiatric hospitalization, acute suicidal ideation) as derived from their intake interview and questionnaires Participants will not be moving out of the San Diego area for the duration of their study enrollment (24 months) Participants will not be pregnant, planning to get pregnant in the 2 year study period or lactating Participants will not be taking medication for weight loss or that may impair physical activity tolerance or performance Participants with medical or psychological problems, or taking medications that could make adherence with the study protocol difficult or dangerous will not be included | 0 |
A 58-year-old African-American woman presents to the ER with episodic pressing/burning anterior chest pain that began two days earlier for the first time in her life. The pain started while she was walking, radiates to the back, and is accompanied by nausea, diaphoresis and mild dyspnea, but is not increased on inspiration. The latest episode of pain ended half an hour prior to her arrival. She is known to have hypertension and obesity. She denies smoking, diabetes, hypercholesterolemia, or a family history of heart disease. She currently takes no medications. Physical examination is normal. The EKG shows nonspecific changes. | eligible ages (years): 20.0-80.0, Hypertension Eligible subjects were untreated hypertensive men or women aged between 20 and 80 years old with SBP between 130 and 179 mmHg and/or DBP between 85 and 109 mmHg as measured in a sitting position Subjects were excluded if they had a history of major cardiovascular disease, severe liver dysfunction, insulin-dependent diabetes mellitus or stroke. They were also excluded if they routinely consumed alcohol, were pregnant or unable to comprehend study instructions | 2 |
A 58-year-old African-American woman presents to the ER with episodic pressing/burning anterior chest pain that began two days earlier for the first time in her life. The pain started while she was walking, radiates to the back, and is accompanied by nausea, diaphoresis and mild dyspnea, but is not increased on inspiration. The latest episode of pain ended half an hour prior to her arrival. She is known to have hypertension and obesity. She denies smoking, diabetes, hypercholesterolemia, or a family history of heart disease. She currently takes no medications. Physical examination is normal. The EKG shows nonspecific changes. | eligible ages (years): 18.0-999.0, Acute Coronary Syndrome Subject with compatible symptoms with an acute coronary syndrome, for at least 15 minutes and not older than 3 hours (eg discomfort, tightness or chest pain, pain radiating to the left arm or two arms, pain in the jaw, pain in the back / neck / stomach, breathlessness , cold sweats, nausea / vomiting , dizziness ) Man or woman Patient Did not receive heparin or low molecular weight heparin (LMWH ) before the initial blood sample Patient Agreeing to participate in the study and who signed an informed consent Minor or major patient trust Patient Not having signed informed consent (refusal , physical or mental disability ... ) Patient Who received anticoagulation before carrying blood samples Patient With a progressive septic processes , neoplasia undergoing treatment, dialyzed kidney failure, a history of surgery or coronary angioplasty less than six months Transplanted heart, renal or hepatic heart attack Subject Whose symptoms clearly eliminates acute coronary syndrome ( penetrating trauma, traumatic injury by crushing ... ) Patient Died between the time of and arrival in the cardiology intensive care ( SIC ) Patient Withdrawing consent under study | 1 |
A 58-year-old African-American woman presents to the ER with episodic pressing/burning anterior chest pain that began two days earlier for the first time in her life. The pain started while she was walking, radiates to the back, and is accompanied by nausea, diaphoresis and mild dyspnea, but is not increased on inspiration. The latest episode of pain ended half an hour prior to her arrival. She is known to have hypertension and obesity. She denies smoking, diabetes, hypercholesterolemia, or a family history of heart disease. She currently takes no medications. Physical examination is normal. The EKG shows nonspecific changes. | eligible ages (years): 18.0-999.0, Abdominal Obesity-Metabolic Syndrome Body mass index more than or equal to 25 kg/m2 Patients with metabolic syndrome Patients who are on anti-hypertensive drugs, oral hypoglycemic drugs and lipid lowering drugs Uncontrolled diabetes patients Patients with gastrointestinal abnormalities Patients with cardiovascular diseases Patients with hematologic disorders Patients with Glomerular filtration rate less than 60 ml/min/1.73m2 Patients with drug or alcohol abuse Pregnancy and lactation | 0 |
A physician is called to see a 67-year-old woman who underwent cardiac catheterization via the right femoral artery earlier in the morning. She is now complaining of a cool right foot. Upon examination she has a pulsatile mass in her right groin with loss of distal pulses, and auscultation reveals a bruit over the point at which the right femoral artery was entered. | eligible ages (years): 0.0-0.5, Thrombosis Parent/legal-guardian has provided written informed consent before initiation of any study related procedures Objectively confirmed thrombotic event by either doppler ultrasound, echocardiogram, CT scan, MRI, MR angiogram, MR venogram, venogram or arteriogram Age less than 6 months Gestational age greater than 35 weeks Expected life expectancy at least 14 days No contraindication to anticoagulation i.e. bleeding complications Active or recent (less than 7 days) bleeding Known allergy to Angiomax or hirudin, or known sensitivity to any component of the product Participation in other clinical research studies involving the evaluation of other investigational drugs or devices within 30 days of enrollment Refusal to undergo blood transfusion should it become necessary Any other disease or condition, which, in the judgment of the Investigator would place a patient at undue risk by being enrolled in the trial Baseline prolonged PT (>18 secs) or aPTT (>55 secs) Platelet count < 50,000 cells/mm3 Birth Trauma Planned or indicated surgery within 30 days Major or minor bleeding event | 0 |
A physician is called to see a 67-year-old woman who underwent cardiac catheterization via the right femoral artery earlier in the morning. She is now complaining of a cool right foot. Upon examination she has a pulsatile mass in her right groin with loss of distal pulses, and auscultation reveals a bruit over the point at which the right femoral artery was entered. | eligible ages (years): 15.0-70.0, Acquired Bleeding Disorder Spinal Fusion Elective spinal fusion surgery History of thrombotic disorders (myocardial infarction, deep vein thrombosis, pulmonary embolism, stroke, disseminated intravascular coagulation or peripheral artery thrombosis) Any trauma within the last 3 months leading to hospitalization > 24 hours Angina or known coronary artery disease | 0 |
A physician is called to see a 67-year-old woman who underwent cardiac catheterization via the right femoral artery earlier in the morning. She is now complaining of a cool right foot. Upon examination she has a pulsatile mass in her right groin with loss of distal pulses, and auscultation reveals a bruit over the point at which the right femoral artery was entered. | eligible ages (years): 18.0-78.0, Cardiac Arrest Non-traumatic collapsed patients, whose pulsation continues and persists more than 5 minutes after return of spontaneous circulation from cardiopulmonary resuscitation and consciousness level is less than GCS 5 points Age > 78 y/o or < 18 y/o 2. Core temperature< 34℃or > 38 ℃ after resuscitation 3. Pregnancy 4. Underline terminal malignancy disorder or refuse aggressive treatment cancer patient 5. Massive bleeding, known coagulopathy, or received regular anticoagulant medication 6. Persisted hypotension ( mean arterial BP < 60 mmHg) after resuscitation even under inotropic agents 7. No bed available in ICU | 0 |
A physician is called to see a 67-year-old woman who underwent cardiac catheterization via the right femoral artery earlier in the morning. She is now complaining of a cool right foot. Upon examination she has a pulsatile mass in her right groin with loss of distal pulses, and auscultation reveals a bruit over the point at which the right femoral artery was entered. | eligible ages (years): 50.0-75.0, Hypertension Postmenopausal women Mild to moderate hypertension Statin therapy or LDL≤ 4.1 mmol/L Severe hypertension LDL > 4.1 mmol/L if not taking anti-hyperlipidemic medication Certain hormonal therapy History of stroke, myocardial infarction, heart failure, chest pain, abnormal heart rhythm Liver, kidney, or pancreas disease Diabetes Raynaud's disease or any other significant peripheral vascular disease Allergy to certain medications used to treat high blood pressure Other protocol-defined inclusion/ | 0 |
A physician is called to see a 67-year-old woman who underwent cardiac catheterization via the right femoral artery earlier in the morning. She is now complaining of a cool right foot. Upon examination she has a pulsatile mass in her right groin with loss of distal pulses, and auscultation reveals a bruit over the point at which the right femoral artery was entered. | eligible ages (years): 18.0-999.0, Pulmonary Embolism Patients >= 18 years of age with pulmonary embolism and cardiogenic shock, defined as a systolic arterial pressure <= 90 mmHg, a drop in systolic arterial pressure >= 40 mmHg for >= 15 minutes, or ongoing administration of catecholamines for systemic arterial hypotension Subtotal or total filling defect in the left and/or right main pulmonary artery due to massive PE, as assessed by chest computed tomography or by conventional pulmonary angiography Right ventricular dysfunction on echocardiography: RV systolic hypokinesis and/or RV dilation (optional) Failed thrombolysis or at least one of the following contraindications to PE thrombolysis present Active bleeding History of intracranial bleeding Surgery, delivery, organ biopsy, puncture of a non-compressible vessel within 10 days History of stroke Gastrointestinal bleeding within 10 days Significant trauma within 15 days Systemic (paradoxical) embolism in the presence of an atrial septal defect or patent foramen ovale Free floating right heart thrombi, left heart thrombi Life expectancy due to underlying disease less than one month | 0 |
A physician is called to see a 67-year-old woman who underwent cardiac catheterization via the right femoral artery earlier in the morning. She is now complaining of a cool right foot. Upon examination she has a pulsatile mass in her right groin with loss of distal pulses, and auscultation reveals a bruit over the point at which the right femoral artery was entered. | eligible ages (years): 18.0-999.0, Healthy Male years and above A negative urine dip-stick Have signed informed written consent to participate The test participant has previous or current congenital deformity, diseases or operation in the lower urinary tract | 0 |
A physician is called to see a 67-year-old woman who underwent cardiac catheterization via the right femoral artery earlier in the morning. She is now complaining of a cool right foot. Upon examination she has a pulsatile mass in her right groin with loss of distal pulses, and auscultation reveals a bruit over the point at which the right femoral artery was entered. | eligible ages (years): 18.0-79.0, Hypothermia Heart Arrest Age between 18 and 79 years old Out-of-hospital cardiac arrest (OH-CA) due to a presumed cardiac etiology Delay between OH-CA and return of spontaneous circulation (ROSC) < 60 minutes Delay between ROSC and starting cooling < 240 minutes Patient not obeying verbal command after ROSC and prior to starting cooling Availability of the "CoolGard" device (ALSIUS product) Do not reanimate order or terminal disease before Known pregnancy Clinical hemorrhagic syndrome or known coagulopathy Contra-indication to device usage (such as femoral venous access impossible) Hypothermia at admission < 30°C Etiology of OH-CA thought to be extra-cardiac (trauma, bleeding or anoxia) In hospital cardiac arrest Refractory shock (need for extra-corporeal life support) | 0 |
A physician is called to see a 67-year-old woman who underwent cardiac catheterization via the right femoral artery earlier in the morning. She is now complaining of a cool right foot. Upon examination she has a pulsatile mass in her right groin with loss of distal pulses, and auscultation reveals a bruit over the point at which the right femoral artery was entered. | eligible ages (years): 18.0-999.0, Peripheral Vascular Disease Written informed consent Age > 18 years If female patient with child bearing potential, patient may not be pregnant at the study entry and must utilize reliable birth control for the duration of her participation into the study Patient is willing and able to comply with the specified follow-up evaluation Critical Limb Ischaemia, this is Fontaine stage III (ischaemic rest pain) and IV (ischaemic ulcers or gangrene) or Rutherford category 4 (ischaemic rest pain), 5 (minor tissue loss) or 6 (major tissue loss) Stenotic (>50% luminal loss) or occluded infrapopliteal artery, including the tibiofibular trunk, the anterior tibial artery, the posterior tibial artery and the peroneal artery, with a lesion length ≤ 60 mm Artery to be treated with a diameter more tham or equal to 2mm and less than or equal to 4mm Patent common iliac, external iliac, superficial femoral and popliteal artery on the ipsilateral side prior to randomisation, possibly after treatment during the same session At least one patent crural (anterior tibial, posterior tibial or peroneal) artery with expected unobstructed runoff to ankle level after treatment Acute limb ischaemia Subacute limb ischaemia which requires thrombolysis as first treatment modality Active bleeding or bleeding diathesis Recent (less than 3 months) hemorrhagic stroke or other any other CNS abnormality with increased risk of haemorrhage, such as intracranial neoplasm, arteriovenous malformation, intracranial aneurysm or aneurysm repair Gastrointestinal or genitourinary bleeding of clinical significance within the previous 6 weeks before treatment Aneurysm in common femoral, superficial femoral or popliteal artery on the ipsilateral side Revascularization involving the same limb within 30 days prior to the index procedure or planned revascularization of the same limb within 30 days of the index procedure Previous implanted stent at the index site Life expectancy of less than 6 months or other factors making clinical follow-up difficult Known allergy to acetylsalicylic acid (aspirin), clopidogrel, heparin or paclitaxel | 0 |
A physician is called to see a 67-year-old woman who underwent cardiac catheterization via the right femoral artery earlier in the morning. She is now complaining of a cool right foot. Upon examination she has a pulsatile mass in her right groin with loss of distal pulses, and auscultation reveals a bruit over the point at which the right femoral artery was entered. | eligible ages (years): 0.0-999.0, Asymptomatic Artery Atherosclerosis is the underlying disease Patients with an asymptomatic stenosis >80% (NASCET) with a documented progression of the degree of stenosis to >80% within 6 months with a very tight stenosis ≥90% at initial presentation with a >80% stenosis plus silent ipsilateral ischemia documented by CCT or MRI with ipsilateral >80% stenosis plus contralateral >80% stenosis or occlusion with >80% stenosis plus planned major surgery Neurologist´s explicit consent to potentially perform CAS Inability to provide informed consent Underlying disease other than atherosclerosis (inflammatory or autoimmune disease) Traumatic or spontaneous carotid dissections Life expectancy <6 months Advanced dementia Advanced renal failure (serum creatinine >2.5 mg/dL) Unstable severe cardiovascular comorbidities (e.g. unstable angina, heart failure) Restenosis after prior CAS or CEA Allergy or contraindications to study medications (clopidogrel, statins, ASA) | 0 |
A physician is called to see a 67-year-old woman who underwent cardiac catheterization via the right femoral artery earlier in the morning. She is now complaining of a cool right foot. Upon examination she has a pulsatile mass in her right groin with loss of distal pulses, and auscultation reveals a bruit over the point at which the right femoral artery was entered. | eligible ages (years): 18.0-85.0, Angioplasty, Transluminal, Percutaneous Coronary Coronary Arteriosclerosis Scheduled for a coronary diagnostic or interventional procedure Able to undergo emergent vascular surgery if a complication requires it arterial puncture located in the common femoral artery Femoral artery has a lumen diameter of at least 5 mm Arterial puncture in the femoral artery of both legs Prior target artery closure with any vascular closure device, or closure with manual compression within 30 days prior to catheterization Patients who bruise or bleed easily or with a history of significant bleeding or platelet disorders Acute ST-elevation myocardial infarction within 48 hours prior to catheterization Uncontrolled hypertension at time of vessel closure Elevated Activated Clotting Time at time of vessel closure Ineligible for in-catheterization lab introducer sheath removal Concurrent participation in another investigational device or drug trial Thrombolytic therapy, bivalirudin, other thrombin-specific anticoagulants, or low molecular weight heparin within 24 hours prior to catheterization Preexisting hematoma, arteriovenous fistula, or pseudoaneurysm at the vessel access site prior to femoral artery closure | 1 |
A physician is called to see a 67-year-old woman who underwent cardiac catheterization via the right femoral artery earlier in the morning. She is now complaining of a cool right foot. Upon examination she has a pulsatile mass in her right groin with loss of distal pulses, and auscultation reveals a bruit over the point at which the right femoral artery was entered. | eligible ages (years): 18.0-999.0, Reconstructive Surgical Procedures Tissue Transplantation Adult patients planned to undergo reconstructive surgery using either a pedicle or free tissue transfer flap seen by The Plastic Surgery Service on either an in-patient or outpatient bases Adult patients that are planned to undergo reconstructive surgery as above and able to receive information regarding the study and provide informed consent to enrollment in the study All emergency reconstructive surgery patients Patients planned to undergo radiation therapy in the region of the reconstructive surgery within 6 months after surgery Patients who develop hypotension requiring the administration of vasopressors either intra-operatively or during the post-operative period prior to discharge from the hospital Patients who develop clinical signs of a surgical site infection at the location of the tissue transfer flap(s) Patients with the development of post-operative anemia requiring a blood transfusion during the first 72 hours after surgery Patients with tattooing or pigmented lesions on the tissue transfer flap Patients who incur injury to the flaps secondary to trauma within 6 months of the reconstructive surgery; with trauma defined as either accidental major trauma resulting in injury to the tissue transfer flap or surgical trauma as a result of further oncologic resection of tissues in close proximity to the tissue transfer flap Minor under the age of 18 years of age Patients deemed unable to comprehend and provide informed consent to enrollment into study due to either a cognitive deficit or medical condition | 0 |
A physician is called to see a 67-year-old woman who underwent cardiac catheterization via the right femoral artery earlier in the morning. She is now complaining of a cool right foot. Upon examination she has a pulsatile mass in her right groin with loss of distal pulses, and auscultation reveals a bruit over the point at which the right femoral artery was entered. | eligible ages (years): 18.0-999.0, Vascular Access Complications Cardiac Catheterization Peripheral Vascular Disease Adults age 18 and over Patients undergoing left heart catheterization or peripheral arterial angiography from the retrograde femoral approach Willingness and ability to sign consent form Scheduled to have procedure performed by operator trained in the ultrasound technique Access from a site other than the common femoral artery Nonpalpable femoral pulses Creatinine > 3.0 mg/dl, unless already on dialysis Prisoners Pregnant women Unable or refusal to sign consent form Patients undergoing emergent cardiac catheterization for ST segment elevation myocardial infarction or unstable acute coronary syndrome Equipment unavailable | 1 |
A physician is called to see a 67-year-old woman who underwent cardiac catheterization via the right femoral artery earlier in the morning. She is now complaining of a cool right foot. Upon examination she has a pulsatile mass in her right groin with loss of distal pulses, and auscultation reveals a bruit over the point at which the right femoral artery was entered. | eligible ages (years): 0.0-999.0, Postoperative Hemorrhages All patients undergoing any percutaneous cardiovascular procedure Patients already enrolled in other clinical trials | 1 |
A physician is called to see a 67-year-old woman who underwent cardiac catheterization via the right femoral artery earlier in the morning. She is now complaining of a cool right foot. Upon examination she has a pulsatile mass in her right groin with loss of distal pulses, and auscultation reveals a bruit over the point at which the right femoral artery was entered. | eligible ages (years): 18.0-85.0, Peripheral Vascular Disease Cardiovascular Disease Subject must be 18-85 Subject must be an acceptable candidate for an elective,non-emergent diagnostic procedure performed percutaneously via the common femoral artery through either a 5F or 6F procedural sheath Subject is an acceptable candidate for emergent vascular surgery Subject agrees to follow-up evaluations to assess for complications related to femoral access site If among the 50 ultrasound sub-study Subjects enrolled,Subject agrees to have an ultrasound of femoral artery performed post-procedure during the 30 ± 7 days follow-up visit Subject or legal representative has been informed of the nature of the study and agrees to provisions and has provided written informed consent as approved by the Institutional Review Board of respective clinical site History of bleeding diathesis or coagulopathy including hemophilia, von Willebrand's disease, and/or a current, known platelet count <100,000 cells/mm3, or baseline INR > 1.7 Body Mass Index (BMI) ³ 35 kg/m2 Presence of significant anemia (Hgb < 10 g/dL, Hct < 30%) Advanced Subject refusal of blood transfusions, should transfusion become necessary | 1 |
A physician is called to see a 67-year-old woman who underwent cardiac catheterization via the right femoral artery earlier in the morning. She is now complaining of a cool right foot. Upon examination she has a pulsatile mass in her right groin with loss of distal pulses, and auscultation reveals a bruit over the point at which the right femoral artery was entered. | eligible ages (years): 1.0-18.0, Hypertension Significant pulmonary arterial hypertension (mean pulmonary artery pressure > 25 mm Hg) Patients aged 4-18 years Routine cardiac catheterization clinically indicated for deciding therapeutic treatment Informed assent/consent from patient/parent Suprasystemic pulmonary artery pressures Evidence of right heart failure History of ventricular arrhythmia Known vascular access arrhythmia Contraindication to Sildenafil Concurrent inotropic / PDE administration Other medical, psychological or social circumstances which complicate a regular participation in the study, and/or increase the risk for the patients themselves No consent/assent Pregnancy or unwillingness to comply with contraceptive advice | 0 |
A physician is called to see a 67-year-old woman who underwent cardiac catheterization via the right femoral artery earlier in the morning. She is now complaining of a cool right foot. Upon examination she has a pulsatile mass in her right groin with loss of distal pulses, and auscultation reveals a bruit over the point at which the right femoral artery was entered. | eligible ages (years): 18.0-80.0, Cardiac Arrest Sustained return of spontaneous circulation (ROSC) after cardiac arrest, for more than 30 min Patients aged between 18 to 80 years Patients who are hemodynamically stable, with a systolic BP > 90 mmHg with or without inotropic support Patients comatose or unresponsive post-resuscitation Hypotension despite fluid and/or vasopressor support Positive pregnancy test in women below 50 years Premorbid status bedbound and uncommunicative | 0 |
A physician is called to see a 67-year-old woman who underwent cardiac catheterization via the right femoral artery earlier in the morning. She is now complaining of a cool right foot. Upon examination she has a pulsatile mass in her right groin with loss of distal pulses, and auscultation reveals a bruit over the point at which the right femoral artery was entered. | eligible ages (years): 18.0-999.0, Cardiac Catheterization All consented pts. over the age of 18 who received sutured mediated femoral vein following catheterization Pt.s who are unable to give consent Pts. whose participation in research is contraindicated for medical reasons are excluded | 0 |
A physician is called to see a 67-year-old woman who underwent cardiac catheterization via the right femoral artery earlier in the morning. She is now complaining of a cool right foot. Upon examination she has a pulsatile mass in her right groin with loss of distal pulses, and auscultation reveals a bruit over the point at which the right femoral artery was entered. | eligible ages (years): 0.0-999.0, Cardiac Arrest Hypothermia ROSC after SCA due to VF/VT or PEA/Asystolia GCS 3 Non-cardiac SCA Pregnancy Unstable Circulation instead of High-dose Inotropics Life-expectancy reducing concomitant illness | 0 |
A physician is called to see a 67-year-old woman who underwent cardiac catheterization via the right femoral artery earlier in the morning. She is now complaining of a cool right foot. Upon examination she has a pulsatile mass in her right groin with loss of distal pulses, and auscultation reveals a bruit over the point at which the right femoral artery was entered. | eligible ages (years): 18.0-999.0, Coronary Artery Disease, Autosomal Dominant, 1 Patient is > 18 years of age (or minimum age as required by local regulations) The patient or patient's legal representative has consented to participate and has authorized the collection and release of his medical information by signing the "Patient Informed Consent Form" All lesions requiring interventions (target lesions one to a maximum of four) in one or more native coronary arteries are amendable for implantation of one or more Endeavor® Zotarolimus Eluting Coronary Stent System Patient indication, lesion length and vessel diameter of the target lesion(s) are according to the 'Indications for Use' as mentioned in the 'Instructions for Use' that comes with every Endeavor® Zotarolimus Eluting Coronary Stent System. Please check the 'Instructions for Use' that comes with the product. Please be aware that the 'Instructions for Use' may be subject to change during the course of the study The patient is willing and able to cooperate with study procedures and required follow up visits Women with known pregnancy or who are lactating Planned elective surgery necessitating discontinuation of clopidogrel within the regular planned period of clopidogrel administration Patients expected not to be compliant with the anti-platelet and/or anticoagulation therapy regimen Previous brachytherapy Previous implantation of a drug eluting stent Previous implantation of a bare metal stent in the preceding year Simultaneous or planned intervention other non cardiac vessels including but not limited to renal artery or carotid artery Current medical condition with a life expectancy of less than 3 years Manifest acute severe heart failure (Killip class III-IV) The patient is currently, and during the first 3 years of the trial, participating in another investigational device or drug study that clinically interferes with the endpoints; or requires coronary angiography or other coronary artery imaging procedures. The patient may only be enrolled in the once | 0 |
A physician is called to see a 67-year-old woman who underwent cardiac catheterization via the right femoral artery earlier in the morning. She is now complaining of a cool right foot. Upon examination she has a pulsatile mass in her right groin with loss of distal pulses, and auscultation reveals a bruit over the point at which the right femoral artery was entered. | eligible ages (years): 19.0-999.0, Arterial Stiffness The patients receiving CRT are medically refractory, symptomatic, NYHA class III or IV disease and QRS duration of 130 m sec or greater, and a left ventricular ejection fraction of 30 percent or less All individuals are carefully selected after appropriate clinical evaluation as determined by the treating physicians to possible reversible causes of heart failure Patients with permanent atrial fibrillation and non-palpable carotid and/or femoral pulses will be excluded due to technical limitations of the procedure used for the measurement of arterial stiffness | 0 |
A physician is called to see a 67-year-old woman who underwent cardiac catheterization via the right femoral artery earlier in the morning. She is now complaining of a cool right foot. Upon examination she has a pulsatile mass in her right groin with loss of distal pulses, and auscultation reveals a bruit over the point at which the right femoral artery was entered. | eligible ages (years): 18.0-999.0, Coronary Angiography Via Femoral Artery Access The patient must be at least 18 years old Patients undergoing femoral access coronary angiography Patient must be competent for providing informed, written consent Only 6F sheath Percutaneous coronary intervention Intra coronary measurements (FFR, IVUS, OCT, NIR) Groin hematoma before closure Pseudoaneurysm or AV fistula Significant stenosis of ilial or femoral artery Prior peripheral artery surgery INR > 3,0 Platelet count < 120 million per millilitre blood Coagulopathy (bleeding disorder) Thrombolysis in the last 24h | 0 |
A physician is called to see a 67-year-old woman who underwent cardiac catheterization via the right femoral artery earlier in the morning. She is now complaining of a cool right foot. Upon examination she has a pulsatile mass in her right groin with loss of distal pulses, and auscultation reveals a bruit over the point at which the right femoral artery was entered. | eligible ages (years): 30.0-80.0, Diabetic Foot Ulcer diabetic foot ulcer < = 80 years old diabetic foot ulcer wegnar 2-4 stage Wagner grade 0,1 and grade 5 severe coronary, cerebral, renal vascular as well as severe liver diseases, malignant neoplasms bleeding individuals > 80 years old heart failure (NYHA 3,4) cancer | 0 |
A physician is called to see a 67-year-old woman who underwent cardiac catheterization via the right femoral artery earlier in the morning. She is now complaining of a cool right foot. Upon examination she has a pulsatile mass in her right groin with loss of distal pulses, and auscultation reveals a bruit over the point at which the right femoral artery was entered. | eligible ages (years): 18.0-85.0, Coagulation Therapeutic Uses Pharmacologic Actions patient/legal representative provides written informed consent Patient is scheduled for a coronary or peripheral diagnostic or interventional procedure Target vessel has a lumen diameter ≥ 6 mm Patient must be willing to comply with follow-up requirements Patient has a 5-7F arterial puncture located in the common femoral artery Arterial puncture in the femoral artery of both legs Manual compression has been preformed on the ipsilateral arterial site within the previous 6 weeks Any closure system has been used on the ipsilateral arterial site within the previous 180 days Any reentry of the ipsilateral site is planned within the next 6 weeks History of surgical repair of blood vessels of the ipsilateral arterial site Patient is unable to ambulate at baseline Significant bleeding diathesis or platelet dysfunction Thrombocytopenia (Plt count ≤ 100,000) Anemia (Hgb ≤ 10mg/dl and/or Hct ≤ 30mg/dl) Hemophilia | 1 |
A physician is called to see a 67-year-old woman who underwent cardiac catheterization via the right femoral artery earlier in the morning. She is now complaining of a cool right foot. Upon examination she has a pulsatile mass in her right groin with loss of distal pulses, and auscultation reveals a bruit over the point at which the right femoral artery was entered. | eligible ages (years): 7.0-18.0, Pain Ages 7-18 years Scheduled for cardiac catheterization through the femoral artery and/or vein under general anesthetic Ability to speak and understand English No apparent cognitive impairments Known allergies to bupivacaine Impaired renal function Impaired hepatic function | 1 |
A physician is called to see a 67-year-old woman who underwent cardiac catheterization via the right femoral artery earlier in the morning. She is now complaining of a cool right foot. Upon examination she has a pulsatile mass in her right groin with loss of distal pulses, and auscultation reveals a bruit over the point at which the right femoral artery was entered. | eligible ages (years): 18.0-999.0, Diabetes Critical Limb Ischemia Adult diabetic patients type 1 or 2 Chronic critical ischemia as defined by TASC 2007 (pain at rest, and/or ulcer or gangrene due to arteriopathy: transcutaneous oximetry < 30 mmHg or pressure on the ankle < 70 mmHg) Cancer with adverse prognosis in months, or chemotherapeutic treatment Ongoing or planned pregnancy Lack of consent to participate to the study | 0 |
A physician is called to see a 67-year-old woman who underwent cardiac catheterization via the right femoral artery earlier in the morning. She is now complaining of a cool right foot. Upon examination she has a pulsatile mass in her right groin with loss of distal pulses, and auscultation reveals a bruit over the point at which the right femoral artery was entered. | eligible ages (years): 18.0-999.0, Coronary Artery Disease Age > 19 years Subject is able to verbally confirm understanding of risks, benefits and treatment alternatives of receiving the drug-eluting stent(s) and he/she or his/her legally authorized representative provides written informed consent prior to any study related procedure Subject must have significant stenosis (>50% by visual estimate) on a native or in-stent coronary artery Subject must have evidence of myocardial ischemia (e.g., stable, unstable angina, recent infarction, acute myocardial infarction, positive functional study or a reversible changes in the ECG consistent with ischemia). In subjects with coronary artery stenosis >75%, evidence of myocardial ischemia does not have to be documented Subject has a known hypersensitivity or contraindication to any of the following medications: heparin, aspirin, clopidogrel, prasugrel, ticagrelor, biolimus A9, everolimus, zotarolimus, stainless steel, cobalt chromium, contrast media (Patients with documented sensitivity to contrast media, which can be effectively premedicated with steroid and diphenhydramine may be enrolled. However, those with true anaphylaxis to prior contrast media should not be enrolled.) Subject in use of systemic (intravenous) biolimus A9, everolimus or zotarolimus within 12 months Female subject of childbearing potential, unless a recent pregnancy test is negative, who possibly plans to become pregnant any time after enrollment into this study Subject planned an elective surgical procedure that would necessitate interruption of antiplatelet during the first 12 months post enrollment Subject with non-cardiac co-morbid condition with life expectancy < 2 year or that may result in protocol non-compliance (per site investigator's medical judgment) Subject with cardiogenic shock at presentation Subject who are actively participating in another drug or device investigational study, who have not completed the primary end point follow-up period | 0 |
A physician is called to see a 67-year-old woman who underwent cardiac catheterization via the right femoral artery earlier in the morning. She is now complaining of a cool right foot. Upon examination she has a pulsatile mass in her right groin with loss of distal pulses, and auscultation reveals a bruit over the point at which the right femoral artery was entered. | eligible ages (years): 18.0-999.0, Coronary Artery Disease Angina Pectoris Myocardial Infarction Age ≥18 years Symptomatic coronary artery disease including patients with chronic stable angina, silent ischemia, and acute coronary syndromes including NSTE-ACS and STE-ACS Presence of one or more coronary artery stenoses >50% in a native coronary artery or a saphenous bypass graft which can be treated with a stent ranging in diameter from 2.25 to 4.0 mm and can be covered with one or multiple stents No limitation on the number of treated lesions, and vessels, and lesion length Pregnancy Known intolerance to aspirin, clopidogrel, heparin, stainless steel, Sirolimus, Everolimus or contrast material Inability to provide informed consent Currently participating in another trial before reaching first endpoint Planned surgery within 6 months of PCI unless dual antiplatelet therapy is maintained throughout the peri-surgical period | 0 |
A physician is called to see a 67-year-old woman who underwent cardiac catheterization via the right femoral artery earlier in the morning. She is now complaining of a cool right foot. Upon examination she has a pulsatile mass in her right groin with loss of distal pulses, and auscultation reveals a bruit over the point at which the right femoral artery was entered. | eligible ages (years): 18.0-999.0, Critical Care Catheterization Patient admitted in the Intensive Care Unit Requiring Central Venous Catheterization Patients with only one site available | 0 |
A physician is called to see a 67-year-old woman who underwent cardiac catheterization via the right femoral artery earlier in the morning. She is now complaining of a cool right foot. Upon examination she has a pulsatile mass in her right groin with loss of distal pulses, and auscultation reveals a bruit over the point at which the right femoral artery was entered. | eligible ages (years): 18.0-999.0, Severe Sepsis Control group male or female aged at least 18 years, matched on age, sex and cardiovascular risk factors (smoking, hypertension, diabetes and treated dyslipidemia) with septic patients Normal clinical examination and normal 12-lead ECG Routines biological tests in the normal range of the laboratories Body mass index between 18 and 27 kg/m² Written informed consent Patients group Male or female aged at least 18 years Severe sepsis defined by the presence of a systemic inflammatory response syndrome Control group legal protection or persons deprived of liberty bacterial or viral infection in the month preceding current medication pregnancy or breastfeeding period stated on the national register for persons who participate to biomedical research Patients group legal protection or persons deprived of liberty vasopressor therapy bacterial or viral infection in the month preceding | 0 |
A physician is called to see a 67-year-old woman who underwent cardiac catheterization via the right femoral artery earlier in the morning. She is now complaining of a cool right foot. Upon examination she has a pulsatile mass in her right groin with loss of distal pulses, and auscultation reveals a bruit over the point at which the right femoral artery was entered. | eligible ages (years): 19.0-90.0, Carotid Stenosis Femoral Arterial Stenosis Carotid Bruit Asymptomatic Carotid Murmur age 19-90 years having clinical ultrasound evaluation of carotid or femoral artery under age 19; over age 90 years | 2 |
A physician is called to see a 67-year-old woman who underwent cardiac catheterization via the right femoral artery earlier in the morning. She is now complaining of a cool right foot. Upon examination she has a pulsatile mass in her right groin with loss of distal pulses, and auscultation reveals a bruit over the point at which the right femoral artery was entered. | eligible ages (years): 18.0-999.0, Cardiac Disease Coronary Artery Disease Over 18 years of age Each patient, or his or her guardian or legal representative, is willing to give informed consent Clinically indicated for an intra-arterial procedure involving access through the common femoral artery and conducted through an access sheath size of between 6F and 7F inclusive Patients with known allergy to any of the materials used in the device Severe acute non-cardiac systemic disease or terminal illness with a life expectancy of less than one year Evidence of systemic bacterial or cutaneous infection, including groin infection Patients suffering with definitive or potential coagulopathy or platelet count <100,000./µl Use of systemic thrombolytic agents within 24 hours prior to or during the catheterisation procedure which cause the concentration of fibrinogen to be < 100 mg/dl or if post-thrombolytic fibrinogen (in case of thrombolysis within 24 hours or intra-procedural) cannot be measured Patients in whom an introducer sheath smaller than 6F or greater than 7F have been used Currently participating in another investigational device or drug study Patients with severe claudication, iliac or femoral artery diameter stenosis greater than 50%, or previous bypass surgery or stent placement in the vicinity of the access site If puncture site is via a vascular graft If a palpable haematoma is observed during the procedure | 1 |
A physician is called to see a 67-year-old woman who underwent cardiac catheterization via the right femoral artery earlier in the morning. She is now complaining of a cool right foot. Upon examination she has a pulsatile mass in her right groin with loss of distal pulses, and auscultation reveals a bruit over the point at which the right femoral artery was entered. | eligible ages (years): 16.0-60.0, Vascular Postoperative Complications Urological System Complication of Procedure Lymphocele Postoperative Infection Patients candidates to renal transplantation Patients with known allergy to products of fibrin seal | 0 |
A physician is called to see a 67-year-old woman who underwent cardiac catheterization via the right femoral artery earlier in the morning. She is now complaining of a cool right foot. Upon examination she has a pulsatile mass in her right groin with loss of distal pulses, and auscultation reveals a bruit over the point at which the right femoral artery was entered. | eligible ages (years): 18.0-89.0, Cardiac Diseases All cardiac surgical patients Non cardiac surgery | 0 |
A physician is called to see a 67-year-old woman who underwent cardiac catheterization via the right femoral artery earlier in the morning. She is now complaining of a cool right foot. Upon examination she has a pulsatile mass in her right groin with loss of distal pulses, and auscultation reveals a bruit over the point at which the right femoral artery was entered. | eligible ages (years): 18.0-999.0, Abdominal Aortic Aneurysm Carotid Atherosclerosis Critical Lower Limb Ischaemia Age greater than 18 years patient willing to give full informed consent for participation Patients undergoing elective carotid endarterectomy or Patients undergoing open abdominal aortic aneurysm repair or Patients undergoing endovascular abdominal aneurysm repair or Patients undergoing surgical lower limb revascularisation (suprainguinal or infrainguinal) Patients less than 18 years of age Patients who are unable or unwilling to give full informed consent Pregnancy Significant upper limb peripheral arterial disease Patients on glibenclamide or nicorandil (these medications may interfere with remote ischaemic preconditioning) Patients with an estimated pre-operative glomerular filtration rate < 30mls/min/1.73m2 Patients with a history of myocarditis, pericarditis or amyloidosis Patients undergoing Fenestrated or branched EVAR | 2 |
A physician is called to see a 67-year-old woman who underwent cardiac catheterization via the right femoral artery earlier in the morning. She is now complaining of a cool right foot. Upon examination she has a pulsatile mass in her right groin with loss of distal pulses, and auscultation reveals a bruit over the point at which the right femoral artery was entered. | eligible ages (years): 18.0-999.0, Acute Ischaemic Stroke Clinical diagnosis of supratentorial acute ischaemic stroke Male or nonpregnant female ≥18 years of age Clinically significant neurological deficit and NIHSS score ≥6 Eligible for IV rtPA according to standard guidelines and able to be commenced on IV treatment <4.5h after symptom onset Enrolment, randomisation and procedure commencement (groin puncture) possible within 90 minutes of the start of IV rtPA treatment (groin puncture maximum 5.5h after stroke onset) Occlusion of the main middle cerebral artery (MCA) trunk, MCA bifurcation or intracranial internal carotid artery(carotidT, M1 or single proximal M2 branch) demonstrated on CTA, MRA, or DSA Interventional device delivery (guide catheter placed beyond aortic arch and angio obtained) can be achieved within 6 hours of onset of the stroke Consent of patient or representative Independent prior to the stroke (estimated mRS 02) Expected to be able to be followed up at 3 months CT evidence of intracranial haemorrhage, or evidence of extensive established hypodensity on CT Clinical history suggestive of subarachnoid haemorrhage even if CT normal Known vascular access contraindications e.g. femoral bypass surgery, tight ipsilateral carotid stenosis, unsuitable proximal vascular anatomy likely to render endovascular catheterisation difficult or impossible Extracranial ICA occlusion or basilar artery occlusion Alternative intracranial pathology potentially responsible for the new symptoms Medical comorbidities which would preclude safe cerebral vessel catheterisation or which are expected to limit life expectancy to <3 months (eg severe cardiac, renal or hepatic failure, significant coagulopathy, metastatic malignancy) Known allergy to radiological contrast | 0 |
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