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Identification, induction and localization of cytochrome P450s of the 3A-subfamily in mouse brain. Several cytochrome P450 subfamilies are inducible by specific exogenous compounds like the antiepileptic drug phenytoin. Some of these P450 enzymes are involved in the metabolism of gonadal hormones also contributing to neuronal differentiation. CYP3A enzymes have the capacity to catalyze the hydroxylation of testosterone and a wide variety of therapeutic agents, but little is known about the expression and potential function of this subfamily in mouse brain. Here, we report the identification of mouse CYP3A isoforms, their induction and localization in mouse brain. Western blot analysis with anti-CYP3A1 antibodies revealed the phenytoin-inducible expression of CYP3A in brain microsomes, and also a constitutive expression of members of this subfamily in brain mitochondria. Using RT-PCR with a consensus primer pair for known mouse liver CYP3A-isoforms we could demonstrate the expression of CYP3A11 and 3A13 mRNA in mouse brain. Finally, using double immunofluorescence labeling we analyzed the histoanatomical distribution of CYP3A throughout the brain with confocal laser scanning microscopy. We found strong immunoreactivity in neurons of hippocampus and hypothalamic areas which are sensitive to steroid hormones. CYP3A immunoreactivity was apparent also in neurons of the cerebellum, the thalamus and the olfactory bulb. Non-neuronal expression of CYP3A could be found in some astrocyte populations and in vascular as well as ventricular border lines. The presence of CYP3A predominantly in neurons but also in cells contributing to the blood-brain and blood-liquor barrier suggests important roles of this subfamily in mediation of steroid hormone action in mouse brain as well as in preventing the brain from potentially cytotoxic compounds. | High | [
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Q: telegram bot keyboard on chat field I want to click a button and have text shown in a chat field and not directly on the chat screen? For example: There is some buttons keyboard [1] [2] [3] When I press on [1] button then 1 is shown on chat field, not on chat screen When I click [3][2][1] then on chat field will be shown 321 When I press <enter> 321 is show on the screen. Question Is this possible on telegram bot? bot.on('ask.no', msg => { let markup = bot.keyboard([ ['9', '8','7','*'], ['6', '5','4','/'], ['3', '2','1','+'], ['.', '0','=','-'], ], { resize: true }); return bot.sendMessage(msg.from.id, 'please input key or number', { markup}); A: As official documentation says: Tapping any of the buttons will immediately send the respective command. No. You can't delay showing button values on chat screen. | Low | [
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<!--This file was generated from the python source Please edit the source to make changes --> CassandraJolokiaCollector ===== Collects Cassandra JMX metrics from the Jolokia Agent. Extends the JolokiaCollector to interpret Histogram beans with information about the distribution of request latencies. #### Example Configuration CassandraJolokiaCollector uses a regular expression to determine which attributes represent histograms. This regex can be overridden by providing a `histogram_regex` in your configuration. You can also override `percentiles` to collect specific percentiles from the histogram statistics. The format is shown below with the default values. CassandraJolokiaCollector.conf ``` percentiles '50,95,99' histogram_regex '.*HistogramMicros$' ``` #### Options Setting | Default | Description | Type --------|---------|-------------|----- byte_unit | byte | Default numeric output(s) | str domains | | Pipe delimited list of JMX domains from which to collect stats. If not provided, the list of all domains will be downloaded from jolokia. | enabled | False | Enable collecting these metrics | bool histogram_regex | .*HistogramMicros$ | Filter to only process attributes that match this regex | str host | localhost | Hostname | str jolokia_path | None | Path to jolokia. typically "jmx" or "jolokia". Defaults to the value of "path" variable. | NoneType mbeans | , | Pipe delimited list of MBeans for which to collect stats. If not provided, all stats will be collected. | list measure_collector_time | False | Collect the collector run time in ms | bool metrics_blacklist | None | Regex to match metrics to block. Mutually exclusive with metrics_whitelist | NoneType metrics_whitelist | None | Regex to match metrics to transmit. Mutually exclusive with metrics_blacklist | NoneType password | None | Password for authentication | NoneType path | jolokia | Path component of the reported metrics. | str percentiles | 50, 95, 99, | Comma separated list of percentiles to be collected (e.g., "50,95,99"). | list port | 8778 | Port | int regex | False | Contols if mbeans option matches with regex, False by default. | bool rewrite | , | This sub-section of the config contains pairs of from-to regex rewrites. | list use_canonical_names | True | Whether property keys of ObjectNames should be ordered in the canonical way or in the way that they are created. The allowed values are either "True" in which case the canonical key order (== alphabetical sorted) is used or "False" for getting the keys as registered. Default is "True | bool username | None | Username for authentication | NoneType #### Example Output ``` __EXAMPLESHERE__ ``` | Mid | [
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WIPP National Partner Karen Barbour Appointed Co-Chair of Governor’s Commission on Small Business The Barbour Group’s President Karen Barbour is Appointed Co-Chair of the Governor’s Commission on Small Business Champion for delivering surety bonding to small businesses joins Commission to represent and provide opportunities for growth to Maryland based small businesses Westminster, MD – February 8, 2011 – The Barbour Group, a Maryland-based surety brokerage known for its passionate approach to helping small businesses find bonding solutions, announced today that President, Karen Barbour has been selected to join and hold the position of Co-Chair on Maryland’s Governor’s Commission on Small Business. The Governor’s Commission on Small Business is a 26 member Commission, made up of leaders of Maryland based small businesses, the Senate President and the Speaker of the House, the Secretary of Business and Economic Development, the Secretary of Housing and Community Development, the Secretary of Labor, Licensing and Regulation, the Secretary of General Services and the Secretary of the Governor’s Office of Minority Affairs. Originally created by Governor O’Malley in 2010, the objective and goal of the Commission is to engage with communities across the State to hear what entrepreneurs are facing and address the barriers that are impacting their business growth. In addition, the Commission is responsible for: Recommending economic policy development measures to the Governor and General Assembly; Overseeing the implementation of the Small Business Task Force recommendations; Developing and recommending a standard definition of small business; Advocating for full employment and skills upgrades to support business development and job creation in emerging and growth industries; Identifying public/private partnership opportunities to supplement small business economic programs and financial incentives; and Identifying methods to improve resource accessibility for small Minority Business Enterprises. I am honored to gain appointment to the Commission as Co-Chair and believe the outcomes will be critical to the betterment of small businesses and business at large in the State of Maryland. I look forward to contributing my experience and expertise to the Commission and working with fellow Commission members to provide the resources and innovative solutions for our State’s small businesses to continue to grow and be successful,” says Karen Barbour, President of The Barbour Group. Since Barbour founded The Barbour Group, in 2002, it has seen consecutive annual sales growth of more than 45%. To date, Barbour has led the company to achieve success in providing surety bonds for the construction industry in more than 30 states and four international countries. Barbour has made a conscious effort of going above and beyond for her clientele including, being active in construction trade associations to help address business issues impacting the contracting industry. She has served as vice chair of the board of the Minority Building Industry Association and on the boards of the American Subcontractors Association of Baltimore and the Washington Building Congress. A champion for small businesses, Barbour is active in public policy and promotes legislation that improves the business climate for contractors and other small businesses operating in the Mid-Atlantic region and beyond. She has initiated, authored and driven landmark legislation in Maryland and on Capitol Hill to develop an amendment to The American Recovery and Reinvestment Act to improve the Small Business Administration’s ability to provide contractor bond guarantees. This legislation has enabled small business, woman-owned, veteran-owned and minority firms more success in capturing bonding capacity. The Barbour Group, LLC is a three-time recipient of Maryland’s TOP 100 Minority Business Enterprise(MBE) award and recently received the distinguished Women’s Business Enterprise National Council (WBENC) Certification for Women Business Enterprises (WBE), becoming the only surety bond focused agency in the Mid-Atlantic region to be recognized with this gold standard and identified as the agency of choice. About The Barbour Group The Barbour Group, based in Westminster, Maryland, provides a comprehensive suite of surety bonding and commercial insurance solutions for small, medium and large construction contractors as well as Fortune 1000 companies. Led by President Karen Barbour, a 26-year veteran of the surety bonding industry, The Barbour Group is known for its dynamic problem-solving approach that combines high degrees of industry knowledge and business acumen with equal measures of passion, persistence and positivity. Unlike typical surety bonding agencies, The Barbour Group combines the insight of a contractor and the experience of a veteran underwriter to find creative business solutions for customers and eliminate the uncertainties of the surety bond approval process. For more information, call (866) 876-9610 or e-mail [email protected]. | Mid | [
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just kept coming. There are times in racing when stuff just comes easily, and that was one of those times when it just seemed like it was really easy to be on the podium! WHEN YOU MOVED UP TO THE 450 CLASS FULL-TIME IN 2011, WAS IT NATURAL TO STAY WITH HONDA. Yes. I had a couple times when I filled in on the CRF450, and even before my last 450 fill-in ride, they offered me a deal, which was, especially for that time in the bad economy, a no-brainer for me. I took the Honda offer, whether there was more opportunity on the table or not. “IT SEEMED LIKE ICOULD DO NOTHINGRIGHT. I SERIOUSLYCONTEMPLATEDHANGING IT UP. IT IS NOTLIKE I POP BACK FROMTHESE INJURIES. IT IS ASTRUGGLE. I CERTAINLYCAME OUT OF MY BACKINJURY A DIFFERENTPERSON.”HOW DO YOU FEEL ABOUT YOUR FIRST FULL-TIME SEASON IN THE 450 CLASS IN 2011? It wasa great rookie season. Yes, it ended short with anotherbroken femur near the end of Supercross, but overallit was good. We were outdoor testing just before theSeattle Supercross when I crashed and broke it. Therewere three rounds left in the series, but at that time therewere five of us within 25 points of the championship lead,and it was a great year. I thought it was the best, mostaggressive riding that I have ever done. I won three racesand was on the podium a few times. I was right there,and that was really cool for me as a rookie to be battlingalongside James Stewart, Chad Reed, Ryan Villopotoand Ryan Dungey. I was pumped because of the level ofrespect that they had for me. They were really generousand kind to me. I felt like I was one of them—not onlyjust competing against them, but having their respect.IN 2012 YOU SUFFERED A NEAR-CAREER-ENDING INJURY, RIGHT? Many people see that,but they do not see the months before that, ending mySupercross season early with a broken femur in 2011 andthen coming back in 2011 for the outdoors and re-break-ing it at Washougal. I came back from that and broke mycollarbone in the off-season leading into 2012. I returnedfrom that really quickly and then broke my back. Thatwas just an emotional roller coaster. To have not just asevere injury, but one that was considered a career-endinginjury was tough for me to come back from. It seemedlike I could do nothing right. I seriously contemplatedhanging it up. It is not like I pop back from these injuries.It is a struggle. I certainly came out of my back injury adifferent person. MANY INJURED RIDERS SAY THAT THE TIME OFF HEALING WAS A BLESSING IN DISGUISE; WAS THIS TRUE FOR YOU? That can be true. I ended up having a lot of time off, and that was when I met my wife Hannah. I have told her that I would have gone through all that again if it meant meeting her. Something good came out of something bad, and I am forever grateful that I got to meet her. That summer was when I got to meet the person that I want to spend the rest of my life with. HOW WOULD YOU CHARACTERIZE YOUR 450 CAREER? Difficult. Even on the local level, there are times when you love it and there are times it is your worst nightmare. I have heard Ralph Sheheen say on the TV broadcasts that injuries are the story of Trey Canard. But, I hope that my career is a story of perseverance—and a story of success. I have won races. I may not be breaking any records, but winning races is something that not everyone is fortunate enough to do. I hope that people don’t look at me as some sort of charity case. I have had a wonderful career, and it is not over. WHEN DID YOU REALIZE THAT HONDA WAS GOING TO GET RID OF YOU? Going into 2016 it really looked like we were going to do a contract extension. But, I had a big crash at the start of the year when my bike went into neutral. I went over the bars and really messed up my groin. I tried to ride through that, but then my hand got landed on, so it was a crummy start. When I heard that they were talking to Ken Roczen, they gave me an option to be a test rider (probably the role that Andrew Short plays now). But, I wanted to keep racing. I hope I represented Honda well. I did the best that I possibly could, and I really appreciate all they did for me. I am happy and grateful for this new venture with Red Bull KTM. I’m excited to work with guys like Roger DeCoster and be teammates with Ryan Dungey and Marvin Musquin. WHAT DO YOU WANT TO ACCOMPLISH IN 2017? I want to win races. As a racer, that is what you want to do, but more than anything, I want to go race to my fullest potential. I still believe that I can be on the podium and be fighting for wins. ANYTHING THAT YOU WANT TO ADD? Racing is a small part of all this. It is easy to get so caught up in it that you miss the good parts of life. I have had a lot of chances to see that, and I am really grateful for that. Had everything gone perfectly for me, maybe I would have missed that. I think I get it as far as life is concerned. I sincerely want to do this, because I love to do it. As part of my faith, I do everything to honor God. I just hope that my story in some way can help people. I believe that in some way people can look at my story and find hope, encouragement and some sort of light there. ❏ | Mid | [
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Are we at the crossroads for Wisconsin child care? The Wisconsin Shares child care subsidy program (WI Shares), launched in 1997 as part of new welfare reform measures, was developed to support low-income families coming off welfare going to work, and to help low-income working families stay off of welfare. The YoungStar quality rating and improvement system began in the fall of 2010, to: (1) promote higher quality by helping programs move up through a 5 Star rating system; and (2) provide better information to parents about the quality of early learning programs that they may access for their children. The two pillars of Wisconsin's child care system, WI Shares and YoungStar, are out of sync. While our state has built YoungStar, which is a good thing, the WI Shares child care subsidy program-once a strong support system for children, families and child care programs-has been seriously eroded and threatens to undermine the YoungStar quality improvement efforts. A quality child care system works by: (1) helping children thrive so they are ready for school and beyond, (2) supporting working families, (3) gaining a significant return on investment, and (4) strengthening Wisconsin's economy. WI Shares and YoungStar together hold the possibility of meeting these important goals. YoungStar has made a great deal of progress and also has great promise for future success in improving the quality of child care in Wisconsin. But there are obstacles to sustaining this progress. Our analysis shows that there is a big gap between the total expenses required to operate a quality program and the available revenue. WI Shares has undergone a huge drop in the number of children participating, especially in rural areas. There has also been an almost $131 million decline in total payments to providers, and an 18% reduction in average monthly payments per child over the last 7 years. There are many reasons for this decline, but the end result is that low payment rates undermine sustainable highquality child care. WCCF has four recommendations to get us back on the right track for developing and maintaining a sound child care system: 1. ECAC Recommendation: Direct Support to High-Quality Programs 2. Improve Child Care Payment Rates 3. Incentives to Maintain a Quality Child Care Workforce 4. Ongoing Research The success of YoungStar and WI Shares depends on making critical investments that prioritize child wellness. We are confident that the recommendations will lead to healthier children, stronger communities, and a vital and viable economy that benefits us all. | High | [
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Monday, 9 December 2013 Husband introduced me to his new colleague the other day, a very nice guy from Belgium. I am getting to realize that expats, some nationalities more than others, tend to gravitate toward and stick with their fellow countrymen. I had seen examples of that before, in the UK, and it always amazed me when people did that; a friend from New Zealand in London used to throw parties where out of 20 people 19.9 would be from New Zealand. So, assuming the new guy would like to know more Belgian people, I asked my compound neighbour if there were many Belgian activities and societies, perhaps, for this guy to join. Oh yes, she replied helpfully. But is he a Flemish Belgian or a French one? Wow, I thought. Being Belgian is not enough! For some nationalities, there are not just groups but also sub-groups they divide into. Still, for the Flemish Belgian guy things will be quite simple, once his belonging to the Flemish side is successfully confirmed. But then there are some of us, who simply do not fit in any group or sub-group this easily. At a party this weekend, I met a lively Polish lady who recently arrived to Doha. We stood there chatting, when an Irish neighbour asked her a natural question: So, have you found other Polish people here yet? The Polish lady thought about it for a while before answering, but I knew what she was thinking straight away. You see, this Polish lady was only technically Polish. However, she lived most of her adult life in Italy. I asked if she, just like I do, finds it hard to hang out with her fellow country men now. Yes, she said. They often asked her awkward, rude questions. Rude to her, but perhaps, to majority of Polish people quite normal. Like how much her salary is, or how come she managed to secure such a great job. And there are, thankfully, people like this Polish/Italian, or Australian/Malaysian, or Lebanese/Australian/British friends of mine, or other people I know who happened to be either married to a different nationality, or influenced by a culture different to their own due to other circumstances in their lives...so much that they would struggle to be friends with others based on nationality. I am grateful these people exist in an expat world, because, frankly, with the national categorization I see every day, I would be quite lonely. Of course, I also occasionally try to find a friend from back home. I have to, right? Everybody else does. There must be certain comfort in it. When you are not quite British, you will never be easily accepted by the proper Brits. Neither are you properly Azeri, not anymore. Neither Russian, despite the Soviet childhood and the language I speak. But I keep hoping that one day, I would find an Azeri abroad who is more like me. Someone I would automatically click with, because we have so much in common. So, when I accidentally found out there was an Azeri neighbour who moved in a compound next door, I walked over to introduce myself. In theory, we had a huge amount in common. Not only was she Azeri, but she also lived abroad a long time. She was also married to an English guy. She must belong, I thought, to my tiny sub-group. There she is, right next door! And the girl was nice. She was friendly and chatty, and it was quite pleasant to be talking to someone from back home, there is no doubt about that. However, in a few minutes of the conversation, she reminded me of the reasons I don't spend all my time hanging out with my fellow countrymen. Why, I thought, why? Why are so many Azeris like this? Even those who are married into a different culture, even those who lived abroad for a long time? It happens almost immediately. Oh, she said, so you live in that compound? We went to look at it before we moved here, and I really hated it. It is so dark! OK, I thought, never mind. Tactless, but let's just move on. We talked about living abroad, we talked about Baku. 'Look, her mother, who was very excited to meet us, pointed out. 'If you lived in Baku right now, would you ever be seen in public looking like this?' She waved her hand in the general direction of my head, leaving me confused whether it was my tied up hair , or the lack of make-up that she found so offensive. And then there were more comments. 'How old is your husband? Oh, funny. Same age as mine, but he looks a lot older!' See what I mean? I walked back home, thinking that the girl was quite nice, really. But…She was not like me. She was really not like me. Not my group, not my sub-group, not the kind of group that any of my friends belong to- wherever they happened to be born, wherever they happened to have lived before, whoever they were married to. Yet, they are all my friends, and we are a group. We are just a diverse group of people who happen to like each other. And maybe I should just realize that some of us don't easily fit anywhere, but that is okay. Because, all around me, there are people who are like me. Just not necessarily Azeri. I had to smile reading this, because it describes my love-hate relationship with the people with whom I share such hypothetically comforting biographical details as a nationality/ ethnicity/ language/ citizenship(s)/ or birth country... In the course of much nomadic movements and three immigrations, I have come to concede that none of that stuff really matters. So what if your new, or non-expat, (or expats from different places) friends don't know the meaning of words such as "halas" and "beseder," or that for New Year's it is customary to eat caviar and Olivier salad and to watch Irony of Fate... In the end, I am not sure that these things truly unite people, or make them naturally closer and more interesting to one another. Nostalgia is a strong brew, but in the end, that's not enough to go on in friendship. Also, it is funny, but it seems to me that a lot of ex-Soviet bloc expats almost comically compete with each other when they meet in situations where they've expected to be one of a kind, and suddenly they are faced with someone with a very similar life story. I have no idea why this happens, but consistently, the element of surprise seems to nip any friendly relationship in the bud... I've kind of stopped trying, to be honest, though I have a hope that one day, maybe, I'll meet someone who gets *all* my complicated film and literary references. It's a beautiful dream, what can I say. Until that day, I occasionally get my husband to watch old films with subtitles with me :P You write so well dearest Scary! I'm jealous of writers who can express themselves so freely. I would love to write someday, do you have any tips maybe? I am majoring in law, but my passion lies in art and English. I think you should not waste this talent of yours :) Best regards, Just another scary Azeri. Baku- Old City Total Pageviews Some cool Azeries Award BlogCatalog About Me Foreign here, foreign there...foreign everywhere. Born in Baku, Azerbaijan, I then spent 12 years in a wonderful commuter village near London, and recently decided to try an expat lifestyle and relocated to sunny Doha. Besides this blog, I run a regular culture clash column in AZ Magazine in Baku, Azerbaijan, and freelance for whoever pays me. | Low | [
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[Fallopian tube primary invasive adenocarcinoma associated with acute inflammatory pelvic disease. Case report and literature review]. The primary fallopian tube invader adenocarcinoma is a preoperative diagnosis rarely reported in the literature, because is the most uncommon of all gynecological tumors, with prevalence from 0.3 to 1.8%. Since its clinical evolution is very unspecific, in general this tumor is diagnosed during a laparothomy for other purpose or by the pathologist in the final histopathological report. The most frequent signs and symptoms are abdominal pain or a pelvic mass in 80% of cases; transvaginal bleeding in 50%, intense transvaginal serohematic discharge (hidrops tubae profluens) in 11.1%, and peritonitis in pelvis in 3.7%. In 25 to 60% of the cases a report of adenocarcinoma in the pap smear with negative endometrial biopsy can be found. The treatment is predominantly surgical, as that of epithelial ovarian carcinoma, and consists of an intraperitoneal washing, total abdominal hysterectomy with bilateral salpingo-oophorectomy and a proper staging. It is required an omentectomy with pelvic and paraaortic lymphadenectomy in systematic way. In the more advanced stages III and IV that required a radical debulking, we have to be very emphatic in citoreduction. In some cases, as the persistence or recurrence of illness, it can be necessary adjuvant chemotherapy. In some patients in early stage I or II with low risk, the complete staging could not be necessary. There is controversy about administration criteria of adjuvant treatment, since there is not evidence of survival increase related to its use. The five years survival rate was 64% for stage I, 42% for stage II, 32% for stage III, and 17% for stage IV. Fallopian tube malignancies are rare and involve a poor prognosis. | Mid | [
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This is an archived article and the information in the article may be outdated. Please look at the time stamp on the story to see when it was last updated. ATLANTA, Ga. (WGCL) — A Georgia bill allowing the limited use of medical marijuana failed to pass both Houses Thursday night. With less than two hours until the 2014 legislative session ended, the House voted 168 to 2 to approve the limited use of medical marijuana for seizure patients sending the bill back to the Senate, but the bill was never brought to the floor for a vote as time ran out. The bill would have allowed families to use cannabis oil to treat some seizure disorders. Supporters say the use of the oil helps patients deal with the disorder that can cause hundreds of seizures a day and can be deadly in some instances. The oil comes from the marijuana plant, but supporters said it does not provide a high. The Senate unanimously approved the original bill, but an amendment was attached to it requiring insurance companies to cover the cost of treating autism in children. That put both proposals in jeopardy when representative Allen Peake, (R) Macon, the author of the marijuana bill, said he did not support the insurance mandate which was proposed by GA. Sen. Renee Unterman. The Senate did vote to study medical marijuana over the next year, but the lack of movement on the marijuana and autism bill was disappointing to many. “We gave them a clean bill that would provide protection from prosecution from possession of cannabis oil when it was obtained legally from another state. We felt like the focus needed to be on that. It was a big first step for our state, and it didn’t need to be tied up with any other bill, and they chose not to vote on it and I am disappointed in that,” said Peake. “Everybody loses not just the children with disabilities, not just the parents fighting for their own children. It costs all of us as more children suffer, and that is an insurmountable problem and you can not put a dollar amount on that,” said Melissa Soleris, the mother of a child with autism. | Low | [
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FSRU Golar Freeze starts new life in Jamaica An existing floating storage and regasification unit chartered in by Miami-based New Fortress Energy Corp has arrived in Jamaica to kick off a second LNG import project for the island. The Golar Freeze (built 1977), which is this week shown as anchored alongside a second Golar vessel working to ship in LNG to the Caribbean island, will be used to supply natural gas to Jamaica Public Service's new Old Harbour power plant, which New Fortress Energy is building. The gas will also supply the new co-generation 94MW power plant at Jamalco's alumina refinery in Clarendon and other industrial customers. An online post this week said that the Golar Freeze will act as New Fortress’ “energy hub” in the region. Long-term business New Fortress has chartered the FSRU for 15 years. It is expected to be based in the Portland Bight area to the south-east of Kingston and remain on station for the entire contract period. The Golar Freeze was previously based in Dubai, where it had been lying idle after being sidelined by charterer the Dubai Supply Authority for a younger unit. It is one of the first generation of FSRUs, which now rank as small and low capacity compared to modern newbuildings, and can provide useful solutions for small-scale importers looking for quick start-up, low-cost options. Are FSRU conversions on the comeback trail? New Fortress is already active in Jamaica. In 2016, the company put the 140,650-cbm LNG carrier Golar Arctic (built 2005) into operation in Montego Bay, after taking the vessel on a two-year charter. The ship has been berthed alongside an existing jetty at Bogue in Montego Bay, where it has been serving as a floating storage unit receiving cargoes from visiting vessels. Small-scale LNG carriers controlled by Dutch shipowner Anthony Veder have been deployed to shuttle cargoes ashore from the FSU. FSRU Golar Freeze starts new life in Jamaica FSRU Golar Freeze starts new life in Jamaica An existing floating storage and regasification unit chartered in by Miami-based New Fortress Energy Corp has arrived in Jamaica to kick off a second LNG import project for the island. The Golar Freeze (built 1977), which is this week shown as anchored alongside a second Golar vessel working to ship in LNG to the Caribbean island, will be used to supply natural gas to Jamaica Public Service's new Old Harbour power plant, which New Fortress Energy is building. The gas will also supply the new co-generation 94MW power plant at Jamalco's alumina refinery in Clarendon and other industrial customers. An online post this week said that the Golar Freeze will act as New Fortress’ “energy hub” in the region. Long-term business New Fortress has chartered the FSRU for 15 years. It is expected to be based in the Portland Bight area to the south-east of Kingston and remain on station for the entire contract period. The Golar Freeze was previously based in Dubai, where it had been lying idle after being sidelined by charterer the Dubai Supply Authority for a younger unit. It is one of the first generation of FSRUs, which now rank as small and low capacity compared to modern newbuildings, and can provide useful solutions for small-scale importers looking for quick start-up, low-cost options. Are FSRU conversions on the comeback trail? New Fortress is already active in Jamaica. In 2016, the company put the 140,650-cbm LNG carrier Golar Arctic (built 2005) into operation in Montego Bay, after taking the vessel on a two-year charter. The ship has been berthed alongside an existing jetty at Bogue in Montego Bay, where it has been serving as a floating storage unit receiving cargoes from visiting vessels. Small-scale LNG carriers controlled by Dutch shipowner Anthony Veder have been deployed to shuttle cargoes ashore from the FSU. Digital subscription Our best value offer. Digital trial 14 day Free Trial More subscription offers NHST Global Publications AS use technologies such as cookies and other tracking scripts to analyse trends, administer our services, track user movements and to gather information about our whole user base. Unregistered users may opt-out of such tracking in the browser settings by ticking off “do not track me”. Read our cookie policy here. | Mid | [
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Real food, ready to eat - The contents are fully cooked and so may be eaten hot or cold. To serve hot: Place unopened pouch in boiling water for 7-8 minutes. Alternatively empty the contents into a suitable saucepan and stir gently whilst heating thoroughly on a camping stove. | Low | [
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Your Outdoor Adventure Just Got Better Outdoor Sporting Goods Welcome to the Field N Water Outdoor Sporting Goods database page. Where you will find thousands of outdoor products listed for sale along with outdoor product reviews. Our product database is updated hourly 24/7. If you’re shopping for mossy oak key lanyard or need a review on mossy oak key lanyard then you have done yourself a huge favor by coming to our website. Description The INOVA XS features the same exceptional engineering you'd expect from the INOVA line, in an unexpectedly compact, lightweight size. Powered by a single AAA alkaline battery, it has a patented optical system - precision-machined aluminum reflector with thermal interface - that provides superior light projection and visibility... Description The INOVA XS features the same exceptional engineering you'd expect from the INOVA line, in an unexpectedly compact, lightweight size. Powered by a single AAA alkaline battery, it has a patented optical system - precision-machined aluminum reflector with thermal interface - that provides superior light projection and visibility... Disclaimer: Even though it appears that Field-N-Water is selling mossy oak key lanyard, let it be known that all mossy oak key lanyard listings displayed are those belonging to eBay and or Amazon.Com as stated in our About Us page. Field N Water has not only been partnered with both companies for the last 10 years,but is authorized by both to list mossy oak key lanyard items and to display such items so you the buyer can get the possible best deals on mossy oak key lanyard on this very day. So act now as the listings shown below are set to expire on Sunday August 2nd 2015. Please check back daily as Field-N-Water, is always adding new mossy oak key lanyard listings on a daily basis. Our Facebook Page #Spinnerbaits are an effective presentation for covering expanses of water looking for #pike. Whether you’re working weed beds, shallow sand flats, or rocky reefs, these #lures are sure to put fish in the boat. Here are some of OUR top tips for targeting pike with spinner baits this #fishing season. | Low | [
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First trimester maternal serum placental protein 13 for the prediction of pre-eclampsia in women with a priori high risk. To evaluate whether first trimester maternal serum PP13 can predict pre-eclampsia among women with a priori high risk. This was a nested case-control study. Women less than 14 weeks' gestation at increased risk of developing pre-eclampsia were recruited. Venous blood samples were assayed for PP13 using enzyme-linked immunosorbent assay. PP13 multiples of median (MoM) were calculated and adjusted for body mass index, ethnicity, smoking, maternal age and parity. For each case of pre-eclampsia (n = 42), five controls were randomly selected. PP13 levels were compared between women who developed pre-eclampsia and controls using the Wilcoxon rank sum test. Sensitivity and false-positive rates were derived from receiver operating characteristic curves. Women who developed pre-eclampsia had significantly lower (P < 0.001) PP13 MoMs compared with controls. PP13 MoMs for controls and pre-eclampsia cases were 1.0 (range 0.0-10.0) and 0.4 (range 0.0-7.0), respectively (P < 0.001). At a MoM cutoff of 0.53, for a false-positive rate of 10%, sensitivity was 50% for pre-eclampsia at term (>37 weeks), 62% for preterm pre-eclampsia (<37 weeks) and 71% for early-onset pre-eclampsia (<34 weeks). First trimester PP13 can predict pre-eclampsia in women at increased a priori risk and predicts early-onset better than late-onset disease. | High | [
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Bundled Payments Bundled Payments = Risk AND Opportunity Episode-based payment initiatives, including Bundled Payments for Care Improvement Advanced (BPCI Advanced), the Oncology Care Model (OCM), and the Comprehensive Care for Joint Replacement (CJR) Model, represent an exciting opportunity for clinical teams to exercise full control over patient care, unencumbered by limitations or artificial constraints imposed by payers. At the same time, bundled payments put more risk for the cost of care on the provider. Success under these types of Alternative Payment Models (APMs) requires the ability to impact patient behavior, manage quality, and drive down unnecessary utilization. Providers without the right team in place are in a precarious position. Furthermore, trying to address these issues with costly clinical resources has proven to be an unsustainable and incomplete solution. Maximize Your Success Guideway Care’s care guidance program supports and extends your care team, giving you the leverage needed to create patient behavioral change, uncover and address the hidden barriers to care within social determinants, and bridge the gaps patients experience in their care journey. The burden of non-clinical activities is lifted from your clinical staff, with everyone working at the top of their licensure, and patients are empowered to take control of their health. In addition, our program has proven results in decreasing unnecessary utilization, improving the financial performance for participants in bundles. Ultimately, your patients have a better experience of care, your care teams are free to focus on clinical tasks, and you are positioned for success under current and future bundles. | High | [
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Is Windows Defender Good Enough? Not Yet One of the most common questions we get asked at Tom's Guide is "Is Windows Defender good enough to protect my PC?" The short answer is: Nope. The longer answer is: No, but it might be someday. Microsoft's built-in antivirus software isn't meant to compete with full-fledged, commercially distributed antivirus software. Instead, when it was first built into Windows 8 in 2012, Windows Defender was intended as a stopgap, a minimum level of defense for the millions of Windows users who hadn't installed any antivirus software on Windows XP, Vista or 7. The problem with Windows Defender is that its malware detection, to put it plainly, sucks. In lab tests conducted since the beginning of 2013, it's stopped about 89 percent of widespread, well-known malware, and about 78 percent of previously unknown "zero-day" malware. The problem with Windows Defender is that its malware detection, to put it plainly, sucks. Because what matters isn't how much malware is stopped, but how much gets through, a detection rate just under 90 percent isn't a B plus — it's an F. Most other products we review, free or paid, stop better than 95 percent of zero-day malware, and 98 or 99 percent of widespread malware. Our best-reviewed products, Avira Free Antivirus and Bitdefender Antivirus Plus, have detection engines that consistently stop between 99 and 100 percent of both categories of malware. That doesn't mean Windows Defender isn't getting better than it once was. It is — slowly. In evaluations conducted on Windows 8.1 in November 2015 by German independent lab AV-TEST, Windows Defender detected 97.5 percent of zero-day malware, and 99.6 percent of widespread malware. But Windows Defender's detection rates are consistently inconsistent. In December 2015, its Windows 8.1 zero-day-detection rate slipped to 90 percent. In earlier tests conducted on Windows 10 by AV-TEST, Windows Defender stopped 80.5 of zero-day malware in September 2015, and 95 percent the following month. (To be fair, it stopped between 99.1 and 99.9 percent of widespread malware in all three instances.) Still, those erratic numbers are a vast improvement from 2013 and 2014, when Windows Defender was scoring about 65 percent against zero-day malware, and about 70 percent for widespread malware. Things may be looking up for Microsoft's free AV software. The Long Road to Microsoft Self-Protection Windows Defender isn't Microsoft's first foray into the antivirus pool. The company had earlier failed with a paid product, Windows Live OneCare, that was discontinued in 2009. OneCare was replaced with Microsoft Security Essentials (MSE), a free download for Windows XP, Windows Vista and the then-new Windows 7. It was MSE, not Windows Defender, that made established antivirus companies cry foul and threaten to complain to antitrust regulators. Then they had a look at the software and breathed sighs of relief. Microsoft Security Essentials turned out to not be half as good as even the best free third-party antivirus product — and Windows Defender is just a rebranded version of MSE for Windows 8 and later. (To be precise, the later Windows Defender incorporates both the active-defense MSE and the earlier Windows Defender, a post-infection malware-cleanup tool.) MSE is still around, protecting countless Windows 7 and Windows Vista machines. Unlike Windows Defender, it must be downloaded and installed manually, although its malware definitions are automatically updated. (The most recent versions don't support Windows XP.) None of this is to say that Windows Defender is terrible; it's better than nothing. As with Windows Defender, MSE's detection rates are all over the place. They bottomed out at the end of 2014, when the software caught 49 percent of zero-day malware in November (according to AV-TEST), and 72 percent of widespead malware in December. MSE peaked in January 2016, when it stopped 91.8 percent of the zero-day bugs and 99.7 of the widespread ones. (Both rates dropped the following month.) The Many Moods of Windows Defender Windows Defender does have its advantages. It doesn't require any installation, is well integrated into Windows, isn't terribly hard to use and has minimal system impact while running in the background. Like other antivirus products, it works by matching files with known malware, analyzing the behavior and code of unknown files and collecting new samples from its users. But Windows Defender also has a heavy system impact during active scans, can be difficult to configure beyond the default settings and doesn't stop non-Microsoft web browsers — anything other than Internet Explorer and Edge — from visiting malicious websites. Most paid antivirus products, and many free ones, work with Mozilla Firefox and Google Chrome, as well as Internet Explorer, to screen out harmful URLs. Most have lighter system loads than Windows Defender during full and quick scans. And many paid ones come with extra features that you'd otherwise have to buy separately, such as password managers, system optimizers or online backup storage. None of this is to say that Windows Defender is terrible. As a last-ditch defense, it's better than nothing, which is what many people had before Windows 8 was introduced. But there are far better ways to protect your PC, whether you want to spend money or not. | Low | [
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BTF PA402Z DRIVER FOR MAC DOWNLOAD Before posting here I also went to sonys site and no luck there. Statement of the day. Helpful 10 Not Helpful Comment Flag. Click here it’s easy and free. Still looking hope to hear from you soon, Mike. I have to agree. Computer Hope Forum Anyone have any suggestions of software to try with this capture card? It’s worth a btf pa402z words. Do whatever you want btf pa402z the package and install via the. In Windows 7 if you look at the HW id in the device manager what does it say anything good? Drivers for a Sony tv card btf-paz What kind of computer do you have and the customer replied a white one why? Before posting here I also btf pa402z to sonys site and no luck there. I have 2 drives in my system that I intend to use this card with dual boot, so if Btf pa402z drivers are only available, since the original Vaio build was XP Home Media Edition thats fine. Having troubles trying to find a driver for it. Genuine Sony Btf-paz Desktop PCI TV Tuner Card AA | eBay Tell us some more! Forum only search News: There is a btf pa402z to the driver right on this website. I looked at MS site for compatibility and no sony tuner cards are listed if we can find the real company that made it I think we will have better luck. Btf pa402z might agree with you both if one of you posted a link where that driver could be btf pa402z for free and minimal hassle! Sony BTF-pa402z Free Driver Download Last edited btf pa402z CeeBee; April 28th, at Please login or register. You may have to register before you can post: Last edited by CeeBee; April 30th, at Ask a Question Usually answered in minutes! I la402z a recent btf pa402z of a win 98 machine that required extensive research in downloading and installing appropriate drivers as it was a build on an early MB designed for XP. Both OS XP and 7 are bit. This group used to try and help people find drivers for windows. The Btf pa402z person asked. Posted on Jan 02, I clicked on the link and it was only kb I don’t know la402z so small it is the real driver or if it safe. Helpful 10 Not Helpful Btf pa402z Flag. Bottom line is that getting this driver is a btf pa402z task. Well, Tbf, don’t take CeeBee’s remarks to heart. So, let me reiterate: Statement btf pa402z the day. The service is completely free and covers almost anything you can think of btf pa402z cars to computers, handyman, and even drones. Everybody learns all the time. MY problem is in taking the card to a non Sony computer and using it in that machine. In any case I put the card back into his machine where it may work and doesn’t icon up in DV. I don’t have to make much money just a little to supplement social security. I had a USB Capture Device with ulead software and so Btf pa402z attempted btf pa402z use that software to use this TV Capture Card and it is able to initialize this Capture Card I am guessing since a btf pa402z green surface mount LED on the capure card goes green when selecting it from devices, but this ulead software does not properly support it other than btf pa402z request from what i can tell. | Mid | [
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module BitcoinClient::Errors class RPCError < StandardError end end | Low | [
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Fathers' Time Spent with Sons and Daughters Description Project Summary Parents are instrumental in the development of their children, and growing research in the U.S. points to the pivotal role of fathers. Father involvement?including time spent with children?has positive impacts on child outcomes. Nevertheless, father involvement is not always equally distributed across sons and daughters. Research in the U.S. finds that fathers spend more time with sons and more time with all children if they have a son. Gender discrimination in fathers' time investments could be even larger in high son-preference settings across Asia, and have a greater impact on the relative well-being of girls and boys. Yet there is scant work on fathers' time investments in high son-preference settings, such as India. The first goal of this project is to conduct analyses using large-scale data from South India to document fathers' time investments in children overall, in sons versus daughters, and by gender composition of siblings in the family (Aim 1). The second goal is to understand what propels fathers' time bias against daughters. We focus on fathers' gender ideology, broadly defined as beliefs toward men's and women's roles in society. Men with egalitarian attitudes view their roles more equally to women's and, therefore, are expected to spend more time in childcare than those who espouse traditional attitudes. Gender theories are completely silent regarding the link between fathers' gender ideology and bias against daughters, however. We suggest that egalitarian fathers will treat sons and daughters more equally and therefore narrow the gender gap in fathers' time investments. Further, our approach recognizes that these relationships could be shaped by mothers' gender ideology. Many mothers in India and elsewhere, given their central responsibility for childrearing, act as gatekeepers who regulate fathers' involvement with children. Thus, mothers' attitudes could influence fathers to curb their time with children, or encourage them to increase their involvement, particularly with daughters. To measure gender ideology, we create a new, multi-dimensional typology using latent class analysis (Aim 2). Using this typology, we tease out which fathers invest more time with their children and display less bias against daughters (Aim 3). We also recognize that any investigation of father involvement with children is incomplete without attention to the larger family context, specifically the extended family in India, including children's grandparents. These individuals could serve as alternative caregivers to fathers and influence fathers' behavior toward sons and daughters. Therefore, accounting for their caregiving time and proximity are crucial. The analysis uses rich data on time use, gender ideologies, and caregiving from the South India Community Health Study (SICHS) in Tamil Nadu, where new roles for fathers coexist with patriarchal preferences for sons. The proposed research addresses a seemingly intractable challenge to health equity globally?gender bias in child investments. Findings regarding how and why fathers treat boys and girls unequally will have important implications for policies and interventions targeting persistent gender disparities in child inputs and outcomes worldwide. | High | [
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Received 19 January 2012; revised 23 February 2012; accepted 8 March 2012 Keywords: Catfish; Mannanoligosaccharides; Growth; Disease ABSTRACT The high temperature and pressure achieved during cooking extrusion has been shown to affect nutrient availability. To determine the effects of extrusion temperature on the efficacy of mannanoligosaccharide (Bio-Mos®) in channel catfish, 4 experimental diets were fed for 9 wks and then challenged with Edwardsiella ictaluri bacterium. Catfish (9.9 ± 0.4 g) were randomly assigned to the following treatments: Low-None (low temperature process without additive); HighNone (high temperature process without additive); Low-Bio (low temperature process with 4 g/kg diet Bio-Mos®); High-Bio (high temperature process with 4 g/kg diet Bio-Mos®). Although specific growth rate and food conversion ratio were similar among treatments (P > 0.10), survival after E. ictaluri challenge was highest (P < 0.01) for the fish fed Low-Bio. Increasing the extrusion temperature of the Bio-Mos®-laden feed resulted in survival numbers similar to diets without Bio-Mos®. Extruding catfish dietssupplemented with Bio-Mos® at lower temperatures may provide another strategy to control enteric septicemia of catfish. 1. INTRODUCTION Bacterial diseases such as enteric septicemia of catfish (ESC), caused by the bacterium Edwardsiella ictaluri, impose a major constraint to channel catfish (Ictalurus punctatus) production. Methods currently used to control this disease include antibiotic therapy, vaccination, and restricted feeding. Another method that has received attention is the addition of immunostimulants to the diet. The use of immunostimulants to improve disease resistance in many species of fish and shrimps has recently been reviewed [1]. Immunostimulants derived from a specific strain of Saccharomyces cerevisiae, (Bio-Mos®; Alltech, Inc., Nicholasville, KY) which has an outer cell wall, rich in mannan oligosaccharides, has shown promise in modulating the immune response, improving feed efficiency, and promoting growth in poultry species [2-5] and fish species [6-9] but the results have been variable. For example, rainbow trout, Oncorhynchus mykiss, fed a BioMos® supplemented diet showed improved weight gain and food conversion ratio (FCR) compared to controls [6]. In European sea bass, Dicentrarchus labrax, dietary Bio-Mos® enhanced growth but had no effect on FCR [7]. Two channel catfish studies have shown that dietary BioMos® had no effect on growth or FCR [8,10]. Similarly, ActiveMos® had no effect on growth or FCR in juvenile giant sturgeon (Huso huso) [9]. The differences in growth performance reported among these studies are not clear but may be species related. Immune responses to fish fed Bio-Mos® have also been variable. For example, mortality was reduced and lysozyme and complement activity were increased in rainbow trout fed Bio-Mos® [6]. In European sea bass, there was a positive correlation between lysozyme and alternative complement pathway activities in blood and inclusion levels of dietary Bio-Mos®, [7]. In addition, the phagocytic index was increased with the inclusion of Bio-Mos®. Contrary to these studies, Welker et al. [10] and Peterson et al. [8] found no correlation between lysozyme and survival or other immune components in channel catfish fed Bio-Mos®. Peterson et al. [8] reported an increase in survival in catfish challenged with E. ictaluri, while Welker et al. [10] found no differences in catfish fed Bio-Mos®. The results of the two studies are hard to interpret as the fish were fed Bio-Mos® for different lengths of time and the Welker et al. [10] study switched to control diet before challenging the fish. Our previous study showed that the improvement in survival after E. ictaluri challenge was higher only in catfish fed a 36% crude protein (CP) sinking diet supplemented with Bio-MosÒ and not in a 32% CP diet extruded at a local feed mill at 255 F [8]. These results would suggest that high extrusion temperature (255 F) has a negative effect on the activity of Bio-MosÒ. However, the extrusion process has not been shown to damage or degrade Bio-MosÒ activity in poultry diets. Feeding a floating pellet is common practice in commercial catfish production. Our previous studies showed that Bio-MosÒ improved survival of channel catfish challenged with E. ictaluri, only when fed a sinking diet. The objective of the current study was to determine the efficacy of feeding yeast-derived mannans in diets extruded at a lower temperature. 2. MATERIALS AND METHODS 2.1. Maintenance of Fish Juvenile catfish (USDA103 strain) were obtained from natural pond spawns at the USDA Catfish Genetics Research Unit, Stoneville, MS, USA. Five hundred catfish (9.9 ± 0.4 g) were randomly assigned to four treatments with five replicates each. An experimental diet (Table 1) was used in a 2 by 2 factorial treatment design with two extrusion temperatures with and without Bio-MosÒ. The four treatments were High-None (127˚C, no additive), Low-None (99˚C, no additive), High-Bio (127˚C, with Bio-MosÒ supplemented at 4 g/kg diet), Low-Bio (99˚C, with Bio-MosÒ supplemented at 4 g/kg diet). These diets were manufactured in the Feeds and Nutrition Laboratory (Fish Technology Service, US fish and Wildlife Service, Bozeman, MT) using a twin-screw cooking extruder (DNDL-44, Buhler AG, Uzwil, Switzerland). The feed mash was not steam conditioned and was exposed to an average target temperature in the barrels of either 99 or 127˚C (Table 2). The barrels were equipped with a steam jacket which was active during extrusion of the high temperature treatments and off during the production of the low temperature treatments. Feeding rate of mash into the extruder (1212 rpm), main drive speed (52%), and moisture added in the barrel (4.65 gph) were held constant for all diets. The 2.0 mm pellets were then dried in a pulse-bed drier (Buhler AG, Uzwil, Switzerland) for approximately 22 min to achieve a discharge temperature of 104˚C, followed by a 10 min cooling period. The fish were stocked into 76 L tanks (25 fish/tank) and allowed to acclimate for 10 days. During the acclimation period, the fish were fed their respective control diets (Low-None and High-None). After the acclimation period, the fish were anesthetized with 0.1 g·L–1 tricaine methanesulfonate (MS-222; Western Chemical Inc., Ferndale, WA) and group weighed to the nearest 0.1 g. The fish were fed the four diets once per day to apparent satiation. Fish were maintained in 26.8˚C ± 0.3˚C flowthrough well water and a 14 L:10 D·h photoperiod. Water quality (pH ~ 8.4 and dissolved oxygen levels > 5.0 mg/L) and flow rates (3.8 L/min) were similar between tanks. The fish were fed the experimental diets for 9 wks and the amount of feed provided was recorded weekly. At the end of the 9-wk growth study, the fish were Table 1. Composition of base diet for experimental feeds processed at different temperatures with and without Bio-MosÒ. One mortality in the High-None treatment was recorded. The fish was taken to the Fish Diagnostic Laboratory at the Delta Research and Extension Center, Stoneville, Mississippi, USA and the cause of death was reported as “unknown.” 2.2. Edwardsiella ictaluri Challenge The fish (N = 25/tank) were challenged with E. ictaluri one day after the fish were weighed and sampled. An E. ictaluri isolate from a natural outbreak (confirmed by the Fish Diagnostic Laboratory) was used for the challenge. Fish were challenged with virulent E. ictaluri (1.9 × 107 cfu/mL; final concentration) by an in situ bath immersion for 30 minutes. Mortality was recorded daily for 21 days. The fish were fed their respective diets during the challenge. Fish were not fed one day prior to challenge nor on the day of the challenge. Studies were conducted in accordance with the principles and procedures approved by the Institutional Animal Care and Use Committee, United States Department of Agriculture/Agriculture Research Service Catfish Genetics Research Unit. 2.3. Statistical Analysis Data were subjected to a two-way ANOVA and the Fisher’s protected least-significant-difference procedure with Statistical Analysis System (SAS) version 9.1 software. Tank served as the experimental unit for each variable measured. A significance level of P < 0.05 was used. 3. RESULTS At the end of the 9 wk growth trial, there was no significant difference in weight gain, specific growth rate (SGR), or food conversion ratio (FCR) among treatments (Table 3) (P > 0.10). Survival after E. ictaluri challenge was higher (P < 0.01) in the Low-Bio (70.0% ± 4.2%) compared to the other three groups (average, 50.0% ± 8.2%). In addition, there was a significant temperature × additive (Bio-Mos®) interaction (P < 0.001). 4. DISCUSSION Results of current study show that the addition of BioMos® at 4 g/kg diet to channel catfish does not improve weight gain, SGR, or FCR when fed for 9 wks. These results are similar to our previous study that also showed there were no differences in growth performance in catfish fed Bio-Mos® for 6 wks [8]. Welker et al. [10] also reported that Bio-Mos® supplementation did not affect total weight gain or FCR during a 4 wk catfish study. Improvements in growth have been reported for chickens [11], pigs [12,13], rainbow trout [6] and European sea bass [7] fed Bio-Mos®. Results from studies that have fed other products derived from S. cerevisiae have also been variable. For example, growth rate and feed efficiency were unaffected in juvenile red drum, Sciaenops ocellatus, fed brewers yeast [14] while growth performance was improved in hybrid striped bass, Morone chrysops female x M. saxatilis male, [15]. Nile tilapia (Oreochromis niloticus) fed a commercial bakers yeast had better growth performance and feed utilization as well as a resistance to Aeromonas hydrophila [16]. Atlantic salmon (Salmo salar) fed dietary supplements of the prebiotics mannanoligosaccharides, fructooligosaccharides in the form of inulin, and galactooligosaccharides had no treatment effects on feed intake or growth while feed efficiency was 5% greater in the salmon fed fructooligosaccharides [17]. Variation in results likely stem from type of yeast-derived mannans used in the study, fish species, feeding duration, and concentration of supplement. Survival after virulent E. ictaluri challenge was higher in Low-Bio compared to High-Bio and the two control diets. Our previous results also showed an improvement in survival after E. ictaluri challenge in catfish fed a sinking Bio-Mos®-supplemented diet for 6 weeks [8]. In that same study, an extruded Bio-Mos®-supplemented diet (~124˚C) made at a commercial feed plant was not effective at reducing mortality to E. ictaluri. In the current study, there was significant temperature × Bio-Mos® interaction, suggesting extrusion temperature had a negative effect on the addition the Bio-Mos® to the diet. It is becoming clear from our studies that the higher extrusion temperature (>124˚C) negatively affects the efficacy of supplemented Bio-Mos® in catfish diets. The extrusion process has not been shown to damage or degrade BioMosÒ activity in poultry diets which are not made to float. There are likely differences in the temperature and moisture combination in the cooling process that may be responsible for the differences observed between supplementing Bio-Mos® to poultry versus catfish diets. In another catfish study, Welker et al. [10] fed channel catfish Bio-Mos® a sinking pellet for 4 wks followed by a 2 wk period of control feed before E. ictaluri challenge. The fish were also fed the control diet for 21 days during the disease challenge. Welker et al. [10] did not observe any improvement in survival. It is likely that the effects of Bio-Mos® were diminished because the fish were switched to control feed 2 wks prior to challenge. BioMos® is intended to be fed on a continuous basis (John Sweetman, Alltech, Inc., personal communication); although short-duration feeding of immunostimulants, followed by control feeding has been shown to be an effective method of enhancing the immune system and disease resistance [18,19]. In commercial catfish production, withdrawing Bio-Mos® 2 wks prior to disease outbreaks in catfish ponds would not be practical since it is difficult to predict when a disease will break in a pond. Studies have demonstrated improvement in disease resistance and improvement of indicators of immune status when fish were administered Bio-MosÒ. In rainbow trout, mortality was reduced and lysozyme and complement activity were increased in fish fed Bio-MosÒ [6]. In European sea bass, there was a positive correlation between lysozyme and alternative complement pathway activities in blood and inclusion levels of dietary Bio-MosÒ [7]. In addition, the phagocytic index was increased with the inclusion of Bio-MosÒ at 4 g/kg. Welker et al. [10] and Peterson et al. [8] found no differences in lysozyme levels in catfish fed Bio-MosÒ. Further studies must be conducted to understand the role of Bio-MosÒ in modulating the immune system in fish. While genetic gains towards developing lines of catfish that show improvement in disease resistance are slow, feeding yeast-derived mannans in the form of BioMosÒ may prove beneficial in increasing resistance to diseases such as ESC. Future research will focus on “ideal” inclusion levels of Bio-MosÒ into catfish diets as well as a more in depth effort into understanding the mechanism(s) through which Bio-MosÒ effects immune function. 5. ACKNOWLEDGEMENTS The authors thank the assistance of Monica Wood of the USDA/ARS Catfish Genetics Research Unit for their efforts in maintaining the fish, disease challenge, and sample collection. The authors would like to thank Dr. Tyler Bramble of Alltech, Inc. for providing support for this project. Mention of trade names or commercial products is solely for the purpose of providing specific information and does not imply recommendation or endorsement by the US Department of Agriculture. | Mid | [
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Erosion and heterotopic bone formation after alloplastic temporomandibular joint reconstruction. Twenty-three temporomandibular joint arthroplasties using metallic condylar prostheses were performed because of severe ankylosis (8 patients), segmental mandibular resections in tumor surgery (9 patients), and after extensive trauma (2 patients). A clinical and radiological follow-up study showed heterotopic bone formation in 52% of cases and glenoid fossa resorption in 43%. In one patient with rheumatoid arthritis the condyle eroded through the skull base 10 months after surgery. Seven prostheses (30%) were removed and/or exchanged during the average 27.6-month follow-up. | Mid | [
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Q: How to keep database changes in-memory before storing them to file on save call? First of all I'm using MagicalRecord to manage my Core Data. So right now my database layer works just great and it saves changes every time the change occurs. For example: I'm adding a new entry to a table and it gets written to db file stored on my hard disc right away. What I want to achieve is to keep all the changes in-memory, and write them to db file only on "save" command click. I figured that the call that does the db file writing is: [managedObjectContext MR_saveToPersistentStoreAndWait]; So as I figured, I can do all my modifications without calling that method, and then on "save" click, call that method. However, it works only if the thread wasn't changed. Every time, the thread changes the ManagedObjectContext gets reset or recreated, and I lose all my data. EDIT: just found method in Magical Record: [NSPersistentStoreCoordinator MR_coordinatorWithInMemoryStore]; which is what I need for the first part of my problem. Although, I don't know how to change from that type of the coordinator to [NSPersistentStoreCoordinator MR_coordinatorWithSqliteStoreNamed:objectModelName]; without losing any data. Does anyone know how to do this right?! Any kind of help is really appreciated! A: I figured it out by doing serious research. I need to use NSPersistentStoreCoordinator *coordinator = [NSPersistentStoreCoordinator MR_coordinatorWithInMemoryStore]; to have my data "hang" before user clicks on save, where I do the following: // psc - my current persistentStoreCoordinator; urlForStore - place where I'm gonna store SQLite [psc migratePersistentStore:[psc persistentStores][0] toURL:urlForStore options:nil withType:NSSQLiteStoreType error:&error]; | High | [
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Eicosanoid production by the mucosa in inflammatory bowel disease after 5-ASA treatment. Eicosanoids were measured in biopsies of colonic mucosa from five patients with active ulcerative colitis before and after a four weeks of treatment with 5-amino-salicylic acid (5-ASA). Eicosanoid formation was determined after the addition of 14C-arachidonic acid and stimulation with calcium ionophore A23187. 5-ASA given intra-rectally caused a non-selective suppression of prostanoids, leukotrienes and hydroxy-eicosatetraenoic acids. Changes in arachidonic acid metabolism after 5-ASA treatment were not always reflected in changes in inflammation score. | High | [
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using JetBrains.Annotations; using Perfolizer.Mathematics.Thresholds; namespace Perfolizer.Mathematics.SignificanceTesting { public class TostResult<T> : EquivalenceTestResult where T : OneSidedTestResult { [CanBeNull] public T SlowerTestResult { get; } [CanBeNull] public T FasterTestResult { get; } public TostResult(Threshold threshold, EquivalenceTestConclusion conclusion, [CanBeNull] T slowerTestResult, [CanBeNull] T fasterTestResult) : base(threshold, conclusion) { SlowerTestResult = slowerTestResult; FasterTestResult = fasterTestResult; } public string ToString(bool details) => details ? ConclusionString() + ": " + (SlowerTestResult?.PValueStr ?? "?") + "|" + (FasterTestResult?.PValueStr ?? "?") : ConclusionString(); private string ConclusionString() => Conclusion == EquivalenceTestConclusion.Unknown ? "?" : Conclusion.ToString(); } } | Mid | [
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Mitch Glasser is an infielder who recently graduated from Macalester College: my school as well as DumpJerry's alma mater. He is a Chicago native whose favorite childhood team was the Sox. Taken in the 39th round, this is big news on campus. I don't know if a baseball player from our little school has ever been drafted. Congrats to Mitch and his family! This was shocking news to me. It's interesting to know of someone from Macalester who will play professional ball at any level. Mitch Glasser is an infielder who recently graduated from Macalester College: my school as well as DumpJerry's alma mater. He is a Chicago native whose favorite childhood team was the Sox. Taken in the 39th round, this is big news on campus. I don't know if a baseball player from our little school has ever been drafted. Congrats to Mitch and his family! This was shocking news to me. It's interesting to know of someone from Macalester who will play professional ball at any level. That is awesome. 2 players from my college (Southeast Missouri State) got drafted today both by the Atlanta Braves. Its pretty cool to see. I have actually gotten to know Mitch very well over the past 4 years. One of my best buddies from HS also played baseball at Macalester College in St. Paul and lived with Mitch throughout college. An absolutely great kid and also a heck of a ball player. One of those crazy athletes that is good at just about any sport. Played golf with him once and he claimed it was the first time he had played in years and he was ripping the ball 280 straight down the fairway every time. Super excited to follow Mitch throughout the minors. I had the chance to speak with him yesterday, and he is just ecstatic. Said he can't wait to sign on the dotted line and go play some ball. Couldn't be happier for him. | High | [
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Transcriptional enhancers control cell-type-specific gene expression. Of the two major types of enhancers in mammalian cells, primed enhancers are marked by histone H3K4 mono-methylation (H3K4me1) while active enhancers are further marked by H3K27 acetylation (H3K27ac). We identified MLL3 (KMT2C)/MLL4 (KMT2D) as the major H3K4 mono-methyltransferases and CBP/p300 as the H3K27 acetyltransferases in mammalian cells (EMBO J 2011; eLife 2013). In search for novel coactivators for the master adipogenic transcription factor (TF) PPARgamma, we identified a nuclear protein complex that contains H3K4me1 methyltransferases MLL3/MLL4, H3K27 demethylase UTX (KDM6A), PTIP, PA1, NCOA6, and the WRAD subcomplex consisting of WDR5, RbBP5, Ash2L and DPY30 (JBC 2007; PNAS 2007). Using adipogenesis and myogenesis as models, we showed that MLL3/MLL4 co-localize with lineage-determining TFs (LDTFs) on active enhancers. MLL3/MLL4 are required for enhancer activation, cell-type-specific gene induction, and cell differentiation (eLife 2013). Using tissue-specific knockout mice, we showed that MLL3/MLL4 are essential for the development of various tissues including adipose, muscle, mammary gland, B cells, T cells, and heart (summarized in Gene 2017). Using adipogenesis, ES cell differentiation and somatic cell reprogramming as model systems, we found that enhancer priming by MLL3/MLL4 controls cell fate transition by orchestrating H3K27 acetyltransferases CBP/p300-mediated enhancer activation (PNAS 2016; NAR 2017). We found that UTX protein, but not its H3K27 demethylase activity, is required for cell differentiation and mouse development (PNAS 2012; MCB 2016; JCI 2016). Our data suggest that UTX functions through MLL3/MLL4 to regulate enhancer activation in differentiation and development. Interestingly, UTX demethylase activity is required for satellite cell-mediated muscle regeneration (JCI 2016). MLL3/MLL4 and UTX are frequently mutated in many types of cancers and developmental diseases. Our findings suggest that mutations in MLL3/MLL4 and UTX would lead to defects in enhancer activation, cell-type-specific gene expression and cell differentiation. Such a mechanism may contribute to the pathogenesis of these cancers and developmental diseases. We reported that the epigenomic reader Brd4 co-localizes with LDTFs on active enhancers during cell differentiation. Brd4 controls cell identity gene induction and is essential for adipogenesis and myogenesis (Nat Comm 2017). Together, our data suggest a model of sequential actions of epigenomic regulators on enhancers: 1) pioneer TFs and LDTFs recruit MLL3/MLL4 to prime enhancer regions and label them with H3K4me1; 2) MLL3/MLL4 facilitate the binding of CBP/p300, which activate enhancers and label them with H3K27ac; 3) H3K27ac and acetylated TFs are recognized by Brd4, which recruits Mediator and RNA Polymerase II to activate cell type-specific gene expression (Nat Comm 2017). We showed that MLL4 protein, rather than MLL4-mediated H3K4me1, controls p300 recruitment to enhancers during ES cell differentiation, suggesting that MLL4 may regulate enhancer activation independent of its enzymatic activity and H3K4me1 (PNAS 2016). Ectopic expression of H3.3K4M, an inhibitor of H3K4 methylation, or deletion of the enzymatic SET domain, in lineage-specific precursor cells destabilizes MLL3/MLL4 proteins, prevents enhancer activation, and impairs cell differentiation and tissue development (NAR 2019). We have generated MLL3/MLL4 enzyme-dead mutant mice. Initial analyses indicate that MLL3/MLL4 regulate mouse development through both enzymatic activity-dependent and -independent mechanisms. | High | [
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The present invention relates to signal processing, and more particularly to voice activity detection, acoustic echo cancellation, and echo suppression devices and methods. Hands-free phones (e.g., speakerphones) provide conveniences such as conversations while driving an automobile and teleconferencing with multiple talkers at a single speakerphone. However, acoustic reflections of the loudspeaker output of a hands-free phone to its microphone input simulate another participant talker and thus appear as an echo to the original remote talker. Thus hands-free phones require acoustic echo control to sufficiently reduce the echo in the sending path (uplink, near-end). Acoustic echo control is done by acoustic echo canceller (AEC) and echo suppressor (ES). AEC estimates the linear echo path between the receiving-side (downlink, far-end) output loudspeaker and the sending-side (uplink) input microphone, and subtracts the estimated echo from the uplink signal. In practical cases, AEC does not completely remove all of the acoustic echo, and ES attenuates the AEC residual echo to make the far-end echo inaudible at uplink output. Typical implementations of AEC and ES functions are in digital systems (e.g., analog signals sampled at 8 kHz and partitioned into 20 ms frames of 160 samples each) where the AEC applies an adaptive FIR digital filter to estimate the echo from the signal driving the loudspeaker and updates the filter coefficients after each frame. Estimation of the echo residual after echo cancellation allows for echo suppression (ES) by gain adjustment. Echo suppression may be applied to degrees of full, partial, or half-duplex communications: see ITU-T Recommendation P.340 Transmission Characteristics and Speech Quality Parameters of Hands-free Terminals (May 2000) and ETSI TR 101 110-GSM 3.58 Digital Cellular Telecommunications System: Characterization Test Methods and Quality Assessment for Handsfree Moblie Stations v.8.0.0 (April 2000). However, if AEC performance is significantly degraded and the AEC residual echo level is the same or higher than near-end speech level ES does not properly distinguish double-talk from far-end echo, makes acoustic system half-duplex by attenuating both far-end echo and near-end speech while far-end is talking. This problem is often observed if severe nonlinear distortion is present in the echo path. For example, in mobile phone speakerphone applications, the loudspeaker is overdriven and the distance between loudspeaker and microphone is short. This phone setting could cause severe nonlinear distortion in the echo path. As a result, conventional ES allows mobile phone to provide only half-duplex communication and significantly degrades communication quality. | Mid | [
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Ian Rapoport of league-owned NFL Network reported the NFL is not expected to punish the Seahawks much, “if at all,” for not reporting their star cornerback’s knee injury late this past season. Coach Pete Carroll disclosed Sherman’s “significant” injury without being asked two days after Seattle’s season ended last month. #Seahawks can breathe easier. Sources say they’re not expected to be penalized heavily – if at all – for not disclosing Sherman’s MCL injury The league reportedly was considering taking away a second-round draft choice from the Seahawks. Seattle is already minus a fifth-round pick in April’s draft for a third violation of too much hitting in what are supposed to be non-contract organized team activities in the offseason. Never miss a local story. Sign up today for unlimited digital access to our website, apps, the digital newspaper and more. In their cooperation with the league’s fourth investigation of the team in six years for potential violations of team rules, the Seahawks assuredly pointed out Sherman not only didn’t miss a game, he played in the Pro Bowl all-star exhibition late last month. "Honestly, I didn't realize we hadn't revealed it," Carroll said last month, two days after Seattle lost in the divisional round of the playoffs at Atlanta. "I don't even remember what game it was, it was somewhere in the middle ... I don't know. "He was fine about it. He didn't miss anything." Carroll mentioned on Jan. 16 that Sherman played with a sprained medial collateral ligament in his knee while describing how difficult a season it was for the three-time All-Pro and how much weighed on him. So what was the big deal? Before the 2016 season began the NFL sent to each of its 32 teams a reminder of its policies on official injury reports. In it is this subsection for practice reports: "The Practice Report provides clubs and fans with an accurate description of a player’s injury status and how much he participated in practice during the week. If any player has a significant or noteworthy injury, it must be listed on the practice report, even if he fully participates in practice and the team expects that he will play in the team’s next game. This is especially important for key players whose injuries may be covered extensively by the media." There are precedents for the league fining teams for not disclosing injuries, particularly to star players. In 2009 the NFL fined the New York Jets $125,000 for not reporting an injury to quarterback Brett Favre, for instance. Sherman’s knee injury never showed up on any of the team’s daily practice reports, nor on injury reports due to the league 48 hours before each game. In six of the last seven game weeks to end the season, he missed one practice. The team listed the reason for those absences as "NIR." That stands for "not injury related." Asked why Sherman’s injury never showed up on a practice report, Carroll said last month: "I don't know. I'm feeling like I screwed that up with not telling you that because that happened, but he was OK. "So I don't know. He never missed anything, which is probably why." The NFL previously investigated the Seahawks in 2012, ’14 and ’16, all for alleged violations of limits on player contact during spring minicamps. All three times the league fined Seattle after finding the team broke NFL rules. In September, the league fined the Seahawks $400,000, Carroll $200,000, took away a fifth-round draft choice this year and three of its OTA/minicamp practices this spring. So it would be a surprise if the Seahawks don’t at least get fined for what appears to be a violation of the league’s practice- and injury-reporting policies. Yet Carroll saying "my mistake" after the fact that Sherman was playing with a significant knee injury and dealing with the possibility of a sanction -- or now perhaps nothing at all -- from the league is preferable to the Seahawks than opponents knowing Sherman was playing while potentially compromised. Foes’ game plans would have targeted that potential weakness with top wide receivers and pass plays. That potentially would have been more costly, in a pragmatic sense of wins and losses, than a possible fine or other league rebuke. Carroll met one more time with Sherman after the team returned from Atlanta early Sunday, before the three-time All-Pro began his offseason. Sherman had a tumultuous December and January. He screamed at offensive coordinator Darrell Bevell and Carroll for play-calling decisions during the Dec. 15 win over the Los Angeles Rams. Then he threatened the career of a Seattle radio host and ended his weekly press conferences he called his "privilege" to the media. "I just wanted to make sure we left on really good terms," Carroll said. "We talk a lot. I talk with him all the time. I just wanted to make sure to touch base one more time, because it was a difficult year for him. "The media thing was a big deal and all that. He made it through it. It was hard." About the Seahawks Insider Blog Gregg Bell joined The News Tribune in July 2014. Bell had been the director of writing for the University of Washington's athletic department for four years. He was the senior national sports writer in Seattle for The Associated Press from 2005-10, covering the Seahawks in their first Super Bowl season and beyond. He's also been The Sacramento Bee's beat writer on the Oakland Athletics and Raiders. The native of Steubenville, Ohio, is a 1993 graduate of the U.S. Military Academy at West Point, N.Y., and a 2000 graduate of the University of California, Berkeley's Graduate School of Journalism. | Low | [
0.49478079331941505,
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One day after being charged with two counts of first-degree murder, YNW Melly has been denied bond. The South Florida Sun Sentinel reported the news this morning (Feb. 14). As was first announced yesterday, Miramar, Fla.'s police department believes the Florida rapper is responsible for the shooting deaths of 21-year-old Anthony Williams and 19-year-old Christopher Thomas Jr., two aspiring rappers whom Melly was said to be close with. Although Melly publicly mourned their deaths, police have reportedly found forensic evidence that point toward him being the person that killed the two men. "Jamell Demons, a.k.a. YNW Melly & Cortlen Henry have been arrested and charged with two counts of first degree murder," begins a statement Miramar Police Department posted last night. "The victims, Anthony Williams & Christopher Thomas Jr., were killed on 10/26/2018. The investigation, supported by forensic evidence, has concluded that Demons shot and killed Williams & Thomas Jr. and that Demons and Henry staged the crime scene to resemble a drive-by shooting." The authorities say Melly is the triggerman and that his friend YNW Bortlen, born Cortlen Henry, helped stage the scene to appear as a drive-by. Cortlen, who authorities arrested in Houston and extradited to Florida last month, has been charged with two counts of first-degree murder and two additional counts of accessory after the fact. He hasn't had a bond set because both the prosecutor and his defense attorney agreed to allow him 24 hours to familiarize themselves with the case. For his part in all of this, Melly maintains his innocence. He left his fans with a message regarding these charges in an Instagram post Wednesday night. In the image in the post, he poses with his two friends killed in the shooting. "To all my fans and supporters no I did not get locked up in Washington , but I am turning myself in today I want you guys to know I love you and appreciate every single one of y’all, a couple months ago I lost my two brothers by violence and now the system want to find justice," Melly wrote. "[Unfortunately] a lot of rumors and lies are being said but no worries god is with me and my brother @ynw.bortlen and we want y’all to remember it’s a ynw Family I love you @ynwsakchaser1 and @ynwjuvy #freeus." See Melly's post for yourself below. | Low | [
0.47011952191235,
29.5,
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Metabolic flux model for an anchorage-dependent MDCK cell line: characteristic growth phases and minimum substrate consumption flux distribution. Up to now cell-culture based vaccine production processes only reach low productivities. The reasons are: (i) slow cell growth and (ii) low cell concentrations. To address these shortcomings, a quantitative analysis of the process conditions, especially the cell growth and the metabolic capabilities of the host cell line is required. For this purpose a MDCK cell based influenza vaccine production process was investigated. With a segregated growth model four distinct cell growth phases are distinguished in the batch process. In the first phase the cells attach to the surface of the microcarriers and show low metabolic activity. The second phase is characterized by exponential cell growth. In the third phase, preceded by a change in oxygen consumption, contact inhibition leads to a decrease in cell growth. Finally, the last phase before infection shows no further increase in cell numbers. To gain insight into the metabolic activity during these phases, a detailed metabolic model of MDCK cell was developed based on genome information and experimental analysis. The MDCK model was also used to calculate a theoretical flux distribution representing an optimized cell that only consumes a minimum of carbon sources. Comparing this minimum substrate consumption flux distribution to the fluxes estimated from experiments unveiled high overflow metabolism under the applied process conditions. | High | [
0.6615384615384611,
32.25,
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Genetic variants in the metabolism of omega-6 and omega-3 fatty acids: their role in the determination of nutritional requirements and chronic disease risk. The tissue composition of polyunsaturated fatty acids is important to health and depends on both dietary intake and metabolism controlled by genetic polymorphisms that should be taken into consideration in the determination of nutritional requirements. Therefore at the same dietary intake of linoleic acid (LA) and alpha-linolenic acid (ALA), their respective health effects may differ due to genetic differences in metabolism. Delta-5 and delta-6 desaturases, FADS1 and FADS2, respectively, influence the serum, plasma and membrane phospholipid levels of LA, ALA and long-chain polyunsaturated fatty acids during pregnancy, lactation, and may influence an infant's IQ, atopy and coronary heart disease (CHD) risk. At low intakes of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), polymorphisms at the 5-lipoxygenase (5-LO) level increase the risk for CHD whereas polymorphisms at cyclooxgenase-2 increase the risk for prostate cancer. At high intakes of LA the risk for breast cancer increases. EPA and DHA influence gene expression. In future, intervention studies on the biological effects of LA, ALA and LC-PUFAs, and the effects of genetic variants in FADS1 and FADS2, 5-LO and cyclooxygenase-2 should be taken into consideration both in the determination of nutritional requirements and chronic disease risk. Furthermore, genome-wide association studies need to include environmental exposures and include diet in the interaction between genetic variation and disease association. | High | [
0.6954177897574121,
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Q: lossy conversion when dividing (long to int) I am trying to find the middle index in an array (of type long) The problem im solving specifically asks for a long to return, so I cant change the signature I want to find the pivot point, in my quicksort code, but I get an error "possible lossy conversion from long to int" I understand that I may lose some information when dividing, but I want to bypass it here is the code containing the error: public static long partition(long[] array, long left, long right){ long i = left, j = right; long tmp; long pivot = array[(left + right) / 2]; // <-----ERROR HERE <------ while(i <= j) { while(array[i] < pivot){ i--; } while(array[j] > pivot) { j--; } if(i <= j) { tmp =array[i]; array[i] = array[j]; array[j] = tmp; i++; j--; } } return i; } A: From JLS Sec 10.4: Arrays must be indexed by int values Using long for the left and right parameters (and i and j) is meaningless (because an array can't have that many elements), and will result in a compile-time error. Change them to int. A: use "array[index]", this "index" must be int. so long pivot = array[(int)((left + right) / 2)]; | Mid | [
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Lentiviral vector-mediated RNAi and its use for cancer research. RNAi is a useful tool for functional analysis of genes and developing a potential therapeutic strategy for various diseases including cancers. RNAi can be applied in various forms. HIV vectors are useful for the stable transduction of genes to both replicating and quiescent cells with a broad host tropism, and have been developed for basic and clinical research of gene therapy. HIV vectors can deliver shRNAs for post-transcriptional silencing of specific genes with high efficiency, and have been used to evaluate various genes for their potential involvement in cancer development and malignant features, and may be useful for future cancer gene therapy. Here we describe the development of shRNA-expressing HIV vectors and their use in cancer research, as well as perspectives for their future use in cancer gene therapy. | High | [
0.6757123473541381,
31.125,
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Minimal clinically important differences in quality of life scores of oral cavity and oropharynx cancer patients. The minimal clinically important difference (MCID) is defined as the smallest difference in quality of life (QOL) that patients perceive as beneficial and that mandates a change in management. We aimed to determine the MCID among patients with oral cavity and oropharyngeal cancer and to identify domains that are significantly affected during treatment. The cohort consisted of 1,011 patients analyzed by a metaanalysis according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement. MCID values for the University of Washington Quality of Life Questionnaire (UW-QOLQ) and European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC C-30) and Head and Neck-35 questionnaires were calculated by using the distribution-based method. The mean MCID for Global QOL was 13.07 points for the UW-QOLQ and 9.43 in the EORTC C-30 questionnaire. High consistency in the MCID values was found between the two questionnaires examined. Heat map analysis indicated a clinically significant improvement in head and neck-associated domains and in domains associated with general cancer treatment 1 year or more after treatment relative to 3 months after treatment (p < 0.001 and p = 0.016, respectively). In contrast, improvement in general and functional domains was not evident 1 year or more after treatment (p = 0.69). This study suggests benchmark values for MCID and variation in QOL scores of oral and oropharyngeal cancer patients after treatment. Improvement in head and neck- and general cancer-associated domains may not be translated into a general and functional improvement during the first year of recovery. | High | [
0.6633663366336631,
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Q: How do i perform a conditional update in SQL with data from multiple tables? Trying to run an update on a column and i'm getting a syntax error on the FROM line connecting the tables UPDATE inv_loc SET inv_loc.product_group_id = 'TEMP' WHERE inv_mast_ud.eh_spk LIKE '%T' FROM inv_mast_ud left join inv_loc on inv_mast_ud.inv_mast_uid = inv_loc.inv_mast_uid A: The WHERE clause belongs at the end of the update join statement: UPDATE il SET il.product_group_id = 'TEMP' FROM inv_loc il INNER JOIN inv_mast_ud imu ON imu.inv_mast_uid = il.inv_mast_uid WHERE imu.eh_spk LIKE '%T'; See SQL update query using joins for a good canonical answer to your question. | Mid | [
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Winslow Fire Chief Ronnie Rodriguez, back center, discusses adding more full-time firefighters with Town Manager Mike Heavener, left, and Town Council Chairman Steve Russell, right, on Friday at the Winslow Town Office. Morning Sentinel photo by Michael G. Seamans WINSLOW — With one of its six full-time firefighters out on medical leave until at least July, the short-staffed Winslow Fire Department has turned to the Town Council for a stop-gap solution. After unanimously approving the hiring of an additional full-time firefighter at its meeting on Monday night, the council met again Friday afternoon to discuss longer-term plans to address the employee shortage. Cam Aucoin will step into the new full-time firefighter position within the next two weeks, according to Fire Chief Ronnie Rodriguez. Aucoin was formerly a member of the department’s part-time call force. Related Headlines While Aucoin’s promotion allows the Winslow Fire Department to meet its minimum staffing requirement — two full-time firefighters on duty during each of the three shifts — Rodriguez told officials that the town’s requirement is well below the level recommended by the National Fire Protection Association. NFPA, Rodriguez wrote in a Dec. 4 email to Town Manager Mike Heavener, recommends a “minimum two in two out rule prior to entering an IDLH (immediately dangerous to life or health) environment.” This problem has reached many municipalities throughout the state, including Waterville, Fairfield and Oakland, for several years. There are currently seven full-time firefighters and 20 part-time, paid-per-call firefighters working for Winslow. On Friday, Rodriguez explained to Heavener and members of the council that in order to meet the national standard, Winslow would need to hire five additional full-time firefighters. Rodriguez is expecting the return of the injured firefighter, Lt. Scott Higgins, in six to eight months, which would bring the total number of full-time firefighters in Winslow to 12 — if the town approves the expansion. The five positions would add $343,000 to the Fire Department’s budget for the upcoming fiscal year. Rodriguez said he could have candidates lined up and ready to start by July 1. The meeting on Friday was informational, and the council did not make any decisions. Councilors Jerry Quirion and Ray Caron were not present. Throughout the conversation, Rodriguez and the council expressed reluctance at the prospect of raising Winslow residents’ taxes. “When I walk down the streets, I’m not the chief, I’m that person that raised my taxes,” he said. “And this is the other thing, but this is serious. These people work hard, and a lot of them are on fixed income.” Councilor Ken Fletcher expanded on that. “Our job as the council is to make decisions, but it involves some obligations to the taxpayers to be able to put the rationale forward as to why this is something we need and that I think … I could talk to somebody and say, ‘Look, here’s the reason: This isn’t a capricious and arbitrary decision. There are situations that we need to deal with, and this is the change, if we decide to do it, that we need.'” Rodriguez acknowledged that many other towns’ fire departments have staggered through staffing shortages of their own, but that Winslow could catalyze positive change throughout the area. “I can’t speak for what another neighboring jurisdiction is going to do, but I can guarantee you that once we do it, they’re going to be saying, ‘They’re on to something; what are we missing?'” Rodriguez said, adding later that “we need to be able to position ourselves for not just now but the future, and that’s where I’m trying to help us get to.” Steve Russell, council chairman, agreed. Winslow Fire Chief Ronnie Rodriguez talks with town officials Friday at the Winslow Town Office about adding more full-time firefighters. “A frustration for me over the years is that … we don’t look at the future enough,” he said. “We don’t think of five-year plans. We’re going from one year to the next.” In his December memo to Heavener, Rodriguez noted that the costs of expanding the department’s full-time staff ultimately could be offset by introducing an ambulance service. That would provide expanded services to Winslow-area residents and also bring in revenue generated from transports, but it would require upfront investments in an ambulance vehicle, equipment and training. “It can be implemented incrementally by purchasing a used ambulance and utilizing the current staff and progressing to using staff licensed at the paramedic level,” Rodriguez wrote. Councilors opted to address that option later. Rodriguez added concern that since stepping in as chief in September, he has observed an average of one to four members of the call force — less than ideal — respond when their service is requested. “There was a fire on Augusta Road (recently),” he told the council. “The third alarm — there were basically four requests for personnel to get here, because there wasn’t enough people to mitigate the incident. If that was a-blazing, … that house would have been gone; and at that point, what good are we?” On top of that, only three out of 20 firefighters in the call force have Firefighter I, Firefighter II and EMT-Basic certifications, which he described as “the necessary level of training to be used in all facets at a fire scene.” This means that when people arrive at a scene, they are not all authorized to perform the same actions. “The thing I’d like for you guys to understand is that out of these (20) people, the way it’s been set up, is when we strike the all-call, I might get two, I might get 15. Regardless of skill or qualification, they come, and if they’re no use to me other than a wheel chock, we’re still paying them.” “And you don’t have the skill set that you need,” Fletcher added. Rodriguez expanded on that in his email to Heavener. “Simply having the desire to join (the call force) does not translate into completion of the training or an ability to respond when needed,” Rodriguez wrote. “The reasons contributing to the failure to complete the training (and respond to scenes) range from an extended training time (every other weekend plus a weeknight for six months), realization that they aren’t suited for this line of work, competing commitments (family changes, job commitments, etc.), and pay.” Rodriguez told the council that to address that, he hopes to create a department policy that would require the completion of Firefighter I and Firefighter II training by a set date. “I’m trying to get us into the 20th century — not the 21st century,” he said Friday. “I’m just trying to get us to where we’re safe and where we need to be.” If the council decides not to hire five additional full-time firefighters in the upcoming budget season, Rodriguez said, alternatives to the staffing shortage could include expanding the call force and hiring firefighters either per diem or part time. He stated that recruiting more members to the call force would be the least costly option, but it would not solve the existing problem of firefighters not being able to respond for various reasons. Hiring individuals per diem or part time would be a more dependable option, with similar downsides, and still less desirable than hiring full-timers. | Mid | [
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(library (name jupyter_comm) (public_name jupyter.comm) (synopsis "A library for communication between Jupyter and notebooks") (modes byte) (modules Jupyter_comm Router Manager Stdin) (flags (:standard -thread (:include %{workspace_root}/config/ocaml_flags.sexp))) (preprocess (pps ppx_deriving_yojson)) (libraries jupyter jupyter.notebook)) | High | [
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Gregor Townsend's men made it four RaboDirect PRO12 wins on the trot to give serious momentum to their play-off push - they are now just three points behind third-placed Munster with a game in hand. The Warriors tallied up in three tries in an impressive first half display, with efforts from Jonny Gray, Sean Maitland and Josh Strauss sending them 22-5 clear by half-time. It was a deserved reward for the Scots' accuracy and aggression, with CJ Stander - Munster's man-of-the-match against Toulouse - posting the hosts' only response. It was a first home defeat of the season for the province - ending a 13-match streak - and Rob Penney's much-changed side produced few moments of inspiration at their eerily quiet Limerick fortress. Showing seven changes from their Heineken Cup quarter-final-winning line-up, Munster allowed the Warriors a 10-point head-start as the imposing Strauss set the early standard in terms of physicality. Young second row Gray followed the flanker's lead by powering through poor attempted tackles from John Ryan and JJ Hanrahan for his first league try. Weir tapped over the simple conversion. Munster prop Ryan was singled out for a ruck penalty that Weir slotted between the posts in the ninth minute, before the hosts' attacking spark was provided by Simon Zebo and Hanrahan. Twice the pair combined to unlock the Glasgow defence and on the second occasion only the outstretched boot of Chris Cusiter prevented Stander from touching down. Just a minute later, Zebo broke through the middle and into the 22 with good hands from centres Keith Earls and James Downey releasing Stander to score to the right of the posts. Hanrahan miscued his conversion attempt and came off with a knock shortly afterwards, but Glasgow soon restored that 10-point buffer with Maitland getting the better of his Lions colleague Zebo to dot down out wide on the right. Scotland international Maitland provided the initial incision as he slipped by Downey and into the hosts' 22. Munster held out until the Warriors moved the ball to the right where Maitland handed off Zebo to make it 15-5. Weir was unable to convert and Munster missed a gilt-edged chance to reply as Stander, having intercepted a pass, opted to kick ahead instead of pass with speed merchant Gerhard van den Heever on his shoulder. The Munster defence was outmuscled again approaching half-time as having been held up close to the posts, the Scots set up man-of-the-match Strauss to reach over past the covering Earls. Weir's successful conversion widened the gap to 17 points at the break, and Munster almost fell further behind in the 49th minute as Ryan Wilson was inches away from a bonus point score - Zebo and Downey combined to deny him. Defences were on top in the third quarter with Munster failing to convert scrum pressure into points and they continued to play below par, emerging scoreless from a succession of visits to the Glasgow 22. The province's execution let them down as they failed to shake off their European hangover, allowing Glasgow to celebrate a fourth victory in their last six trips to Ireland. | Mid | [
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Q: Parsing a JSON date time with AngularJS I have a simple Spring MVC app which is accepting POST, GET and DELETE requests. At the front end I have a simple JSP page which is importing AngularJS libaries and trying to parse the incoming JSON. I serialized the JSON with Jackson. Below is the JSON response coming from my Spring MVC app and I want to get it with ng-bind like this: <td><span ng-bind="u.creationDate"></span></td> This is how my JSON date time looks like: { "dayOfMonth": 12, "year": 2000, "dayOfWeek": 2, "era": 1, "dayOfYear": 347, "chronology": { "zone": { "fixed": true, "id": "UTC" } }, "yearOfEra": 2000, "centuryOfEra": 20, "yearOfCentury": 0, "monthOfYear": 12, "weekyear": 2000, "weekOfWeekyear": 50, "fields": [ { "lenient": false, "minimumValue": -292275054, "maximumValue": 292278993, "rangeDurationField": null, "leapDurationField": { "unitMillis": 86400000, "precise": true, "name": "days", "type": { "name": "days" }, "supported": true }, "durationField": { "unitMillis": 31556952000, "precise": false, "name": "years", "type": { "name": "years" }, "supported": true }, "name": "year", "type": { "durationType": { "name": "years" }, "rangeDurationType": null, "name": "year" }, "supported": true }, { "lenient": false, "minimumValue": 1, "maximumValue": 12, "rangeDurationField": { "unitMillis": 31556952000, "precise": false, "name": "years", "type": { "name": "years" }, "supported": true }, "leapDurationField": { "unitMillis": 86400000, "precise": true, "name": "days", "type": { "name": "days" }, "supported": true }, "durationField": { "unitMillis": 2629746000, "precise": false, "name": "months", "type": { "name": "months" }, "supported": true }, "name": "monthOfYear", "type": { "durationType": { "name": "months" }, "rangeDurationType": { "name": "years" }, "name": "monthOfYear" }, "supported": true }, { "minimumValue": 1, "maximumValue": 31, "rangeDurationField": { "unitMillis": 2629746000, "precise": false, "name": "months", "type": { "name": "months" }, "supported": true }, "lenient": false, "durationField": { "unitMillis": 86400000, "precise": true, "name": "days", "type": { "name": "days" }, "supported": true }, "unitMillis": 86400000, "name": "dayOfMonth", "type": { "durationType": { "name": "days" }, "rangeDurationType": { "name": "months" }, "name": "dayOfMonth" }, "supported": true, "leapDurationField": null } ], "fieldTypes": [ { "durationType": { "name": "years" }, "rangeDurationType": null, "name": "year" }, { "durationType": { "name": "months" }, "rangeDurationType": { "name": "years" }, "name": "monthOfYear" }, { "durationType": { "name": "days" }, "rangeDurationType": { "name": "months" }, "name": "dayOfMonth" } ], "values": [ 2000, 12, 12 ] } How can I properly display this date using AngularJS? A: From your JSON response, it appears that you're using DateTime from the Joda-Time library, but you're missing Jackson support for Joda. You should add the following Maven dependency: <dependency> <groupId>com.fasterxml.jackson.datatype</groupId> <artifactId>jackson-datatype-joda</artifactId> </dependency> If you're not using Joda, but you're using the Java 8 time API, you can add support by adding the following dependency: <dependency> <groupId>com.fasterxml.jackson.datatype</groupId> <artifactId>jackson-datatype-jsr310</artifactId> </dependency> If you're using Spring boot, this module will automatically be recognized and loaded by Jackson. When you run your application now, your JSON should be a simple UNIX timestamp: {"timestamp":1476709730090} If you prefer a proper looking ISO datetime string, you can use the following properties in Spring boot: spring.jackson.serialization.write-date-timestamps-as-nanoseconds=false spring.jackson.serialization.write-dates-as-timestamps=false This will output something like: {"timestamp":"2016-10-17T13:13:41.386Z"} Now you should be able to easily convert this with AngularJS/JavaScript by using: obj.timestamp = new Date(obj.timestamp); You can wrap this in a service/put it in transformResponse and afterwards you can use the AngularJS date filter to properly format your date, for example: <td><span>{{obj.timestamp | date:'short'}}</span></td> | Mid | [
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package com.tencent.wstt.gt.analysis4.obj; /** * Created by p_hongjcong on 2017/7/31. */ public class LowSMInfo { public long startTime; public long endTime; } | Low | [
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08 Jun Fed up doctor a�?hiresa�� friends to date ex-wife Siphathisiwe Tshumahow to buy viagra without prescription. A BULAWAYO doctor, seemingly fed up with telling an ex-wife that their relationship was over, hatched a plan to end the relationship by a�?hiringa�? aspiring boyfriends to propose to her in order to get rid of her. Kainos Taruvinga did not have any other means to distance himself from his ex-wife, Chenjerai Chai (pictured above) besides sending other men to entertain her so that he could also live in peace. The revelations are the two started off as patient and doctor. However, things took a twist when they decided to date. The two started an affair and ended up getting married. Things did not go as planned as they both realised that they were not perfect for each other. This forced Taruvinga to move out of the house, leaving Chai with their two-month-old child in 2016. Taruvinga wanted nothing to do with Chai and stopped looking after their daughter. B-Metro caught up with Chai who said that she felt Taruvinga took advantage of her situation and Taruvingaa��s friends had alerted her that he was now sending them to ask her out. a�?I understand that now Taruvinga is sending men to ask me out. I dona��t know the reason behind all this. All l want from him is to pay for wasting my time and dumping me with his daughter. He will not get away with this. I am really hurt.a�? Chai she believes Taruvinga planned all this drama because the time their second child died, they buried him on their own without any family members, meaning he did not want her known to his family. Taruvinga denied all the allegations saying that he even paid lobola but it was Chaia��s traumatic behaviour that forced him to leave her before it was too late. a�?I dona��t know what Chai is talking about.A� I left because I was afraid she will end up killing herself as she was threatening to kill herself. Even some of her family members advised me to leave her because she has been violent ever since,a�? he said. a�?I am not sending any men to her. I moved on with my life, I dona��t care what she is doing. As I speak l gave her US$150 last weekA� to help maintain our daughter,a�? he concluded. | Low | [
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Q: Identity Server 4 - Logout - Passing Additional Data When a user logs out under certain circumstances I want to show them a message on the logged out page. To enable this I want to be able to send an optional parameter from the client to the Identity Server / Authority site on logout. While I have the standard logout flow working I have hit a brick wall in handling this scenario as information seems thin on the ground and the suggested solutions are not working. From what I have read the 'state' parameter is the correct way to pass this information but this not coming through currently. AcrValues are only used to send information the other way. My naive implementation below simply adds a state query string item to the end session endpoint. However, when I check the query string my client uses to go to the identity server instance it is missing. Redirect(discoveryResponse.EndSessionEndpoint+"&state=foo") Any help gladly received! Current flow for MVC client: Please note; some code has been removed for brevity. Logout initiated from client controller with state=foo: public class LogoutController : Controller { public ActionResult Index() { Request.GetOwinContext().Authentication.SignOut(); var discoveryClient = new DiscoveryClient(clientConfig.Authority) { Policy = {RequireHttps = false} }; var discoveryResponse = discoveryClient.GetAsync().Result; var tokenClaim = ((ClaimsIdentity)User.Identity).FindFirst("id_token"); return Redirect(discoveryResponse.EndSessionEndpoint+ "?id_token_hint="+ tokenClaim + "&state=foo"); } } RedirectToIdentityProvider is called for request: IdTokenHint and PostLogoutRedirectUri are set and passed correctly. app.UseOpenIdConnectAuthentication(new OpenIdConnectAuthenticationOptions { Notifications = new OpenIdConnectAuthenticationNotifications { RedirectToIdentityProvider = n => { if (n.ProtocolMessage.RequestType != OpenIdConnectRequestType.LogoutRequest) return Task.FromResult(0); var idTokenHint = n.OwinContext.Authentication.User.FindFirst(OpenIdConnectClaimType.IdToken); if (idTokenHint == null) return Task.FromResult(0); n.ProtocolMessage.IdTokenHint = idTokenHint.Value; n.OwinContext.Response.Cookies.Append("IdentityServerPostLogoutReturnUri", n.ProtocolMessage.PostLogoutRedirectUri); n.ProtocolMessage.PostLogoutRedirectUri = n.Options.PostLogoutRedirectUri; return Task.FromResult(0); } } URL Generated (not the lack of 'state' item): http://localhost:44362/connect/endsession?post_logout_redirect_uri=http%3a%2f%2flocalhost%3a2577%2fpostloginredirect&id_token_hint=removed&x-client-SKU=ID_NET&x-client-ver=1.0.40306.1554 Logout page on the authority site: This is where I want to be able to access the state parameter. public class LogoutController : Controller { public async Task<ViewResult> Index(string logoutId) { if (logoutId == null) throw new Exception("Missing logoutId"); var logoutRequest = await interactionService.GetLogoutContextAsync(logoutId); var vm = new LoggedOutViewModel(logoutRequest, logoutId); if (!string.IsNullOrWhiteSpace(httpContextService.GetCookieValue(PostLogoutReturnUriCookieKey))) { vm.PostLogoutRedirectUri = httpContextService.GetCookieValue(PostLogoutReturnUriCookieKey); httpContextService.ClearCookie(PostLogoutReturnUriCookieKey); } await httpContextService.SignOutAsync(); return View("Index", vm); } } A: I've dug a little deeper and found what the issue was being caused by the following lines in the Microsoft.Owin.Security.OpenIdConnect middleware. protected override async Task ApplyResponseGrantAsync() { AuthenticationResponseRevoke signout = Helper.LookupSignOut(Options.AuthenticationType, Options.AuthenticationMode); if (signout != null) { // snip var notification = new RedirectToIdentityProviderNotification<OpenIdConnectMessage, OpenIdConnectAuthenticationOptions>(Context, Options) { ProtocolMessage = openIdConnectMessage }; await Options.Notifications.RedirectToIdentityProvider(notification); // This was causing the issue if (!notification.HandledResponse) { string redirectUri = notification.ProtocolMessage.CreateLogoutRequestUrl(); if (!Uri.IsWellFormedUriString(redirectUri, UriKind.Absolute)) { _logger.WriteWarning("The logout redirect URI is malformed: " + redirectUri); } Response.Redirect(redirectUri); } } } In order to prevent the middleware from overriding the redirect when it detects a sign out message the following line in the 'HandleResponse' method needs to be called in the RedirectToIdentityProvider event. This allows the original 'state' query string item to be passed to Identity Server and be pulled out using the interaction service. app.UseOpenIdConnectAuthentication(new OpenIdConnectAuthenticationOptions { // Snip Notifications = new OpenIdConnectAuthenticationNotifications { AuthorizationCodeReceived = async n => { // Snip }, RedirectToIdentityProvider = n => { // Snip n.HandleResponse(); // The magic happens here } } | Low | [
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Thursday, May 14, 2009 Recipe Tuesday! Chicken and Rice!! I went to a mothers brunch the other day and this was the meal that was served with different kinds of fruit. It was so delicious so I asked them to share the recipe. They were so generous to share that is was a Paula Deen Recipe.I made it while my mom was here visiting. This entree serves 6-8 easily, so it would be great for pot luck gatherings or if you needed to take a meal to a friend who just had a baby or a sick friend who just came home from the hospital--- Of course if you love to cook you could make it for just about anyone and it wouldn't eat up your grocery budget! | Low | [
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Rooney Mara and Emily Blunt Racing to Be Johnny Depp's Wife in 'Transcendence' December 13, 2012 04:31:30 GMT Rebecca Hall is also in the running to star as the leading lady of Depp's Max, whose brain is uploaded into a supercomputer by his wife following his death. Johnny Depp still hasn't found his leading lady in "Transcendence" and at least two Hollywood beauties ere vying to fill the vacant role. Per Deadline, the project has shortlisted Oscar nominee Rooney Mara and Golden Globe winner Emily Blunt as the leading contenders for the coveted part. Blunt is still busy with her other project "All You Need Is Kill", but her schedule reportedly will be adjusted. Another actress who is eyed for the female lead part is "Iron Man 3" star Rebecca Hall. Words are, the final decision will be announced on Friday, December 13. "Transcendence" will mark the directorial debut from Oscar-winning cinematographer Wally Pfister. The project is set to kick off on March 4, 2013 with Jack Paglen serving as the screenwriter. Christopher Nolan and Emma Thomas, meanwhile, will tackle the executive producing duty. So far, details of the movie are still scarce, but it is said that the story will be in the vein of "2001: A Space Odyssey" and "Inception". Depp will play Max, a scientist who gets his brain uploaded into a computer, which can develop a malevolent awareness, following his death. The one who does the job is a female scientist named Evelyn, who is also Max's wife. No release date is set for the project, but it will likely make its way out onto the cinemas sometime in mid 2014 or early 2015. | Mid | [
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All relevant data are within the paper and its Supporting Information files. Introduction {#sec005} ============ During the past few decades, the incidence of colorectal cancer has increased worldwide\[[@pone.0190497.ref001]\].There were 1,363,000 newly diagnosed cases worldwide, which led to 693,900 deaths in 2012\[[@pone.0190497.ref002],[@pone.0190497.ref003]\]. The colorectal incidence in Taiwan(44.32/100000) is high. There were 15,140 newly diagnosed cases leading to 5,265 deaths in 2013\[[@pone.0190497.ref004]\]. Approximately 25% of patients with colorectal cancer have metastatic disease with a clinically significant detrimental effect on prognosis\[[@pone.0190497.ref005],[@pone.0190497.ref006]\]. With the administration of chemotherapy and target therapy, the median overall survival time of metastatic colorectal cancer(mCRC) has improved from 12 to 33 months(in KRAS wild-type patients)\[[@pone.0190497.ref007],[@pone.0190497.ref008]\].However, the response rate of chemotherapy apparently decreased in the further therapies\[[@pone.0190497.ref009]--[@pone.0190497.ref012]\]. The identification of a chemotherapy with a higher response rate has attracted increasing attention and is addressed in the present study. Regorafenib is an orally available, small-molecule multikinase inhibitor that targets signaling pathways implicated in tumor angiogenesis(VEGF receptors 1--3 and TIE2), oncogenesis(KIT, RET, RAF1, and BRAF), and the tumor microenvironment (platelet-derived growth factor receptor and fibroblast growth factor receptor)\[[@pone.0190497.ref012]\]. Evidence of activity of regorafenib in metastatic colorectal cancer was demonstrated in two international randomized Phase III trials(CORRECT and CONCUR)\[[@pone.0190497.ref013],[@pone.0190497.ref014]\]. These trials indicated that regorafenib monotherapy improved overall survival compared with the placebo dose (6.4 months vs 5.0 months, hazard ratio\[HR\] 0.77, 95% CI 0.64--0.94; *p* = 0.0052 in CORRECT and 8.8 months vs 6.3 months, \[HR\] 0.55, 95% CI 0.40--0.77; *p* = 0.00016 in CONCUR). However, adverse events (AE) of regorafenib were apparent, which were most likely observed as hand-foot skin reaction(HFS), diarrhea, fatigue, and elevated liver function. Adverse events are more frequent observed in Asians, and tolerance was lower\[[@pone.0190497.ref015]\].Currently, clinical practice use a dose-escalation protocol at certain institutes\[[@pone.0190497.ref016],[@pone.0190497.ref017]\].which may increase drug compliance and with relatively the same effect. Regorafenib was approved for the treatment of mCRC by the US Food and Drug administration in September 2012\[[@pone.0190497.ref018]\], and approved in mCRC treatment by the Taiwan National Health Insurance Scheme (NHI) since September 2015\[[@pone.0190497.ref019]\]. The superiority of combination use of target therapy with chemotherapy was demonstrated in Cetuximab in 2004\[[@pone.0190497.ref020]\]. The effect of regorafenib combination use remains unknown. We collected mCRC patients from our institute who had received regorafenib combined with chemotherapy and compared these individuals with patients who received only reforafenib to observe differences in the therapeutic effects and side effects between these groups. Methods {#sec006} ======= Study design and patients {#sec007} ------------------------- The present study was a retrospective cohort study; data was collected during September 2015 to May 2017 in a single institute ([Fig 1](#pone.0190497.g001){ref-type="fig"}). In Taiwan, chemotherapy for metastatic colorectal cancer was paid for by the NHI according to NCCN guidelines\[[@pone.0190497.ref021]\]. Irinotecan-based chemotherapy (FOLFIRI), and anti-VEGF or anti-EGFR(for k-ras wild type) target therapy were the first line chemotherapies. If the disease progressed, then the patients received a second-line oxaliplatin based(FOLFOX) chemotherapy. In the third-line chemotherapy, anti-EGFR target therapy was used for KRAS wild type, and if anti-VEGF was used in first line, then regorafenib was administered to ([Fig 2](#pone.0190497.g002){ref-type="fig"}). {#pone.0190497.g001} {#pone.0190497.g002} Eligible patients in the present study were pathologically confirmed for colorectal cancer, presented with metastasis and had received target therapy with disease progression within 3 months. The evaluation scale for measurable or non-measurable metastatic disease is according to Response Evaluation Criteria in Solid Tumor(RECIST) version 1.1.23\[[@pone.0190497.ref022]\]. The patients were adults (\>18 years of age) with an Eastern Cooperative Oncology Group performance status of 0 or 1 and adequate bone-marrow, liver, and renal function at the start of the treatment. Procedure {#sec008} --------- We collected data from patients who received regorafenib therapy for metastatic colorectal cancer from September 2015 to May 2017. Patients with an expected life span of fewer than 3 months, brain metastasis, double cancer, regorafenib treatment further than fourth line therapy, or an unclear therapy record were excluded. We verified that the patient records were de-identified and anonymous. Because of the adverse events of regorafenib, the standard dose was not applicable in every patient. Most physicians applied a dose-escalation protocol, which started with regorafenib at 80 mg per day with possible dosage modifications on each OPD to manage drug concentration and toxic effects. In the study group, there were chemotherapy agents used with regorafenib therapy of either 5-FU based agents, oxaliplatin, irinotecan, FOLFOX, or FOLFIRI. The choice of chemotherapy was determined according to the physicians\' discretion. The dosage of these drugs was determined according to previous study. Tegafur /Uracil: 300 mg/m^2^/day, capecitabine: 2500 mg/m^2^, oxaliplatin: 85 mg/m^2^ per 2 weeks, irinotecan: 180 mg/m^2^ per 2 weeks, modified FOLFOX6: 2 hour infusion of oxaliplatin (85mg/m^2^) and folinic acid (100 mg/m^2^) followed by a 46 hours of continuous infusion of 5-FU (2,400 mg/m^2^), FOLFIRI: 90 minutes infusion of irinotecan (180 mg/m^2^) and folinic acid (100 mg/m^2^) followed by a 46 hours of continuous infusion of 5-FU (2,400 mg/m^2^). In the control group, regorafenib was used without any chemotherapy. Clinical condition was followed in the outpatient department(OPD) or during hospitalization every 2 weeks, including history-taking, a physical exam, and a laboratory exam. The tumor marker, CEA and CA-199, were assessed every 6--8 weeks, and chest X-ray, abdomen CT, or PET were performed every 10--14 weeks or once if there was a clinical condition that needed to be performed. Survival status was collected by a colorectal cancer case manager in the hospital ([Table 1](#pone.0190497.t001){ref-type="table"}). 10.1371/journal.pone.0190497.t001 ###### Patients characteristic in the present study. {#pone.0190497.t001g} Single use (n = 27) Combine (n = 34) *p* value ---------------------------------------------- --------------------- ------------------ ----------- -------------- ------------------------------------------------ **Sex** 1.000 F 12 (44.4%) 14 (41.2%) M 15 (55.6%) 20 (58.8%) **Age**[†](#t001fn002){ref-type="table-fn"} 60.0 (54.0, 73.0) 63.0 (58.8, 73.3) 0.292 **ECOG** 0.162 0 2 (7.4%) 8 (23.5%) 1 25 (92.6%) 26 (76.5%) **Drug** XeLIRI or FOLFIRI 0 (0.0%) 5 (14.7%) Ufur or Xeloda 0 (0.0%) 7 (20.6%) FOLFOX 0 (0.0%) 1 (2.9%) Irino 0 (0.0%) 19 (55.9%) Oxa 0 (0.0%) 2 (5.9%) **Initial dosage (mg)** 0.429 80 24 (88.9%) 29 (85.3%) 120 0 (0.0%) 2 (5.9%) 160 3 (11.1%) 3 (8.8%) **Tumor site** **0.039**[\*](#t001fn003){ref-type="table-fn"} Cecum 3 (11.1%) 0 (0.0%) Ascending colon 1 (3.7%) 3 (8.8%) Transverse colon 1 (3.7%) 0 (0.0%) Descending colon 0 (0.0%) 5 (14.7%) Sigmoid colon 5 (18.5%) 11 (32.4%) Rectum 17 (63.0%) 15 (44.1%) **Side** 0.447 Right 5 (18.5%) 3 (8.8%) Left 22 (81.5%) 31 (91.2%) **Ras mutation** 1.000 Wild type 12 (44.4%) 15 (44.1%) Mutant type 15 (55.6%) 19 (55.9%) **Time when regorafenib was used** 0.940 2nd line 8 (29.6%) 10 (29.4%) 3rd line 14 (51.9%) 18 (52.9%) 4th line 5 (18.5%) 6 (17.6%) **Had received adjuvant therapy in stage 3** FOLFOX 8 (29.6%) 11 (32.4%) 1.000 **Target therapy beforeregorafenib**. 0.153 Bevacizumab 17 (63.0%) 20 (58.8%) Cetuximab 6 (22.2%) 3 (8.8%) Bevacizumab+ Cetuximab 4 (14.8%) 11 (32.4%) **Chemotherapy before regorafenib** 1.000 FOLFIRI /XeLIRI 12 (44.4%) 16 (47.1%) FOLFOX 0 (0.0%) 0 (0.0%) FOLFIRI and FOLFOX 15 (55.6%) 18 (52.9%) Chi-square test. †Mann-Whitney U test, Median (IQR) \*p\<0.05 \*\*p\<0.01 Ethics statement {#sec009} ---------------- The present study was approved by ethics committees of Taichung Veterans General Hospital in Institutional Review Board(II) 106-B-06 Board Meeting. IRB number: CE17123B. The patients provided informed written consent to have data from their medical records used in the present study. We verified that patient records were de-identified and anonymously analyzed. Outcome {#sec010} ------- The primary endpoint was overall survival(OS) (time from regorafenib initiation to mortality by the disease). For these patients, regorafenib might have been the last line treatment. Median overall survival time reflected the disease control rate of the drug. Secondary endpoints were progression-free survival(PFS) (time from regorafenib initiation to clinical evidence including symptoms or radiologic images of disease progression), the proportion of patients who achieved disease control 3 months after treatment, and adverse effects (any grade of symptomatic event, and hematological events). We reported adverse events and laboratory abnormalities using the National Cancer Institute Common Terminology Criteria for Adverse Events category and worst grade. Statistical analysis {#sec011} -------------------- The present study compared regorafenib combination therapy and monotherapy. Analyses were performed using the Statistical Package for the Social Science (IBM SPSS version 22.0; International Business Machines Corp, New York, USA). We compared the overall survival and progression-free survival using a stratified log-rank test and calculated HRs (with 95% CIs) using the Cox model, adjusting for baseline stratification factors. We calculated Kaplan-Meier survival estimates for each treatment group. We provide descriptive statistics and 95% CIs for overall survival and progression-free survival analyses. The study was designed to confirm our hypothesis that combination therapy would extend median PFS and OS. The PFS in the study group was expected to be 3.5 months compared with 1.7 month based on the results of a previous study. A two-sided log rank test with an overall sample size of 68 subjects (34 in the control group and 34 in the treatment group) achieves 80.4% power at a 0.050% significance level to detect a hazard ratio of 00.4857. Role of the funding source {#sec012} -------------------------- The present study received little funding. The present study was a retrospective, double arm cohort study for the mCRC patients treated in single institute. Collection of data, medical documents, laboratory data, and statistical analyses were conducted by the authors and the Biostatistics Task Force of Taichung Veterans General Hospital, who were responsible for the study results. Results {#sec013} ======= The baseline characteristics of both groups were not significantly different. In the combination treatment group, regorafenib was combined with FOLFIRI in 4 (11.8%) patients, Ufur/Xeloda in 7 (20.6%) patients, FOLFOX in 2 (5.8%) patients, Irino in 19 (55.9%) patients, and oxaliplatin in 2 (5.8%) patients. There were 2 patients who received a combination of regorafenib with oxaliplatin, and these individuals had undergone FOLFOX for second line therapy without discomfort. Oxaliplatin was added to regorafenib. By dose-escalating protocol, initial dosage was 80 mg per day in 29 (85.3%) patients in the combination group and 24 (88.9%) patients in the single use group. A total of 160 mg per day in 3 (8.8%) patients in the combination group and 3 (11.1%) patients in the single use group. Regorafenib was used as a second line treatment after metastasis was confirmed in 10(30.3%) patients in the combination group and 8(29.6%) patients in the single use group. In third line treatment in 18(54.5%) patients in the combination group and 14(51.9%) patients in the single use group. Fourth line treatment: 5(15.2%) vs 5 (18.5%). Before regorafenib, 20(58.8%) patients had received Avastin, 3(8.8%)patients had received cetuximab, and 11(32.4%) patients received both of treatments in the combination group. Avastin: 17(63.3%); cetuximab: 6(22.2%); Both: 4(14.8%) in the single use group. Median follow up time was 10.4 months in the combination group and 6.1 months in the single use group. After regorafenib treatment with a dose-escalation protocol, there were 2(6.9%) patients with increased dose in the combined use group and 2(8.3%) patients in the single use group. A total of 4(13.8%) patients showed a decreased dose in the combined use group and 3(12.5%) patients in the single use group. The final regorafenib daily dosages were 40 mg in 4/34(11.8%), 80 mg in 27/34(79.4%), 120 mg 1/34(2.9%), 160 mg in 2/34(5.9%) in combined use group and 3/27(11.1%), 19/27(70.4%), 2/27(7.4%), and 3/27(11.1%) in the single use group. The dosage of regorafenib was not different between combination use and single use. Median therapeutic duration was 4.5 months(2.8--6.8) in the combination group and 2.9 months(2.0--4.0) in the single use group(*p* = 0.037). Disease control rate after three months treatment was 47.1%(16/34) in the combination group and 11.1%(3/27) in the single use group. Ending of regorafenib treatment was due to disease progression: 70.6%(24/34) in the combination group and 70.4%(19/27) in the single use group; or adverse effects: 23.5%(8/34) vs 25.9%(7/27). The adverse effects of combination use did not increase the risk of treatment failure([Table 2](#pone.0190497.t002){ref-type="table"}). 10.1371/journal.pone.0190497.t002 ###### Results of the present study. {#pone.0190497.t002g} Single use (n = 27) Combine (n = 34) *p* value -------------------------------------------------------- --------------------- ------------------ ----------- ------------- -------------------------------------------------- **Final dosage (mg)** 0.734 40 3 (11.1%) 4 (11.8%) 80 19 (70.4%) 27 (79.4%) 120 2 (7.4%) 1 (2.9%) 160 3 (11.1%) 2 (5.9%) **Response after 3 months treatment** **0.006**[\*\*](#t002fn004){ref-type="table-fn"} Progress Disease (PD) 24 (88.9%) 18 (52.9%) Stable disease (SD) 3 (11.1%) 16 (47.1%) **Reasons to stop regorafenib** 0.914 Progress Disease (PD) 19 (70.4%) 24 (70.6%) Adverse events (AE) 7 (25.9%) 8 (23.5%) Regorafenib was ongoing 1 (3.7%) 2 (5.9%) **Duration of regorafenib** 2.9 (2.0, 4.0) 4.5 (2.8, 6.8) **0.037**[\*](#t002fn003){ref-type="table-fn"} **Follow-up time**[†](#t002fn002){ref-type="table-fn"} OS 6.1 (5.3, 10.5) 10.4 (5.7, 13.1) 0.058 PFS 2.5 (1.6, 3.6) 4.0 (2.5, 5.9) **0.014**[\*](#t002fn003){ref-type="table-fn"} Chi-square test. †Mann-Whitney U test, Median (IQR) \*p\<0.05 \*\*p\<0.01 The primary end point of overall survival(OS). The OS curve is shown in [Fig 3](#pone.0190497.g003){ref-type="fig"}. Median OS was 20.9(10.1--31.7) months in the combination group and 10.3(8.3--12.3) months in the single use group (*p* = 0.015). A second end point of progression-free survival(PFS) ([Fig 4](#pone.0190497.g004){ref-type="fig"}) was 3.7(2.2--5.2) months in the combination group and 2.5(1.7--3.4) months in the single use group (*p* = 0.009). A total of 58.3% patients remained alive at the 1-year follow up in the combination group and 26.8% patients in the single use group. The combination group had longer overall survival and progression-free survival. {#pone.0190497.g003} {#pone.0190497.g004} Overall, there were 27 patients (79.4%) suffered from any grade of adverse effect in combination group and 18 patients (66.6%) in single use group ([Table 3](#pone.0190497.t003){ref-type="table"}). Most frequently seem were hand food skin reaction (HFSR), gastrointestinal discomfort, and fatigue. Adverse effects predominantly noted in combination group were mucositis (14.7% vs 3.7%), diarrhea (11.8% vs 3.7%), neutropenia (11.8% vs 3.7%), and thrombocytopenia(2.9% vs 0%). 10.1371/journal.pone.0190497.t003 ###### Adverse effects occurring after treatment. {#pone.0190497.t003g} Single use (n = 27) Combine (n = 34) *p* value ------------------------------ --------------------- ------------------ ----------- --------- ------- **Any events** 18 (66.6%) 27 (79.4%) 0.406 **HFSR** 12 (44.4%) 16 (47.1%) 1.000 **headache** 1 (3.7%) 1 (2.9%) 1.000 **mucositis** 1 (3.7%) 5 (14.7%) 0.317 **N/V** 6 (22.2%) 7 (20.6%) 1.000 **Diarrhea** 1 (3.7%) 4 (11.8%) 0.371 **Hypertension** 1 (3.7%) 0 (0.0%) 0.443 **Fatigue** 7 (25.9%) 6 (17.6%) 0.639 **Discomfort** 2 (7.4%) 0 (0.0%) 0.374 **Liver function elevation** 2 (7.4%) 3 (8.8%) 1.000 **Thrombocytopenia** 0 (0.0%) 2 (5.9%) 0.498 **Hair loss** 0 (0.0%) 2 (5.9%) 0.498 **Neutropinia** 1 (3.7%) 4 (11.8%) 0.371 Chi-square test. \*p\<0.05, \*\*p\<0.01 Discussion {#sec014} ========== The optimal dosage for regorafenib is not known. The suggested dosage was 160mg per day for 3 weeks and rest for 1 week according to the best drug concentration recommended in a previous study\[[@pone.0190497.ref023]\]. However, drug compliance was not good and most patients needed adjustments. The minimal daily dose of regorafenib allowed was 80mg\[[@pone.0190497.ref024]\]. This dose was selected as no data on antitumor activity was generated with lower concentrationsin a previous study\[[@pone.0190497.ref025]\]. Thus, certain physicians started regorafenib at 80 mg daily for the first week, escalated the dosage to 120 mg daily for the second week if no significant side effect was observed, and subsequently escalated the dosage again to 160 mg daily, for the third week, then scheduled a break for the fourth week\[[@pone.0190497.ref016]\]. At our institute, most physicians initiated regorafenib at the 80-mg daily dose. Dosage up-regulation was determined at the physicians' discretion. Most patients remained at 80 mg daily at our institute. Another real-life regorafenib experience was shared by Ka-On Lam et al., who recruited 45 patients in three institutes in Hong Kong\[[@pone.0190497.ref026]\]. A total of 25 patients were treated at a lower dose, and 20 patients were started at a full dose. Median overall survival time was not inferior in low dose regorafenib (51.3 weeks vs 27.4 weeks, p = 0.449) nor was median progression-free survival time (18.7 weeks vs 13.4 weeks, *p* = 0.458). The adverse effects of a full dose of regorafenib made this dosage not practical in every case. Hence, low dose initiation was relatively feasible in clinical practice and might confer the same effect. There was a Phase IB study by B. Schiltheis that analyzed the combination of regorafenib with FOLFOX or FOLFIRI in first or second line chemotherapy\[[@pone.0190497.ref027]\]. The study recruited 45 patients using combination therapy with regorafenib 160 mg daily and standard FOLFOX or FOLFIRI. Median PFS was 126 days. Similar PFS between first line and second therapy either combined with FOLFOX or FOLFIRI was noted. Adverse effects were acceptable. However, combination use was not suggested due to more adverse effects and non-superior outcomes to chemotherapy alone. Regorafenib combination use was reported by Wang et al\[[@pone.0190497.ref028]\]. Regorafenib combined with FOLFIRI was used in a metastatic colorectal cancer patient in fourth line therapy after FOLFIRI, FOLFOX, cetuximab, and bevacizumab were used. The dosage of regorafenib was 160mg daily and FOLFIRI was initiated from 180 mg/m^2^ for irinotecan with subsequent up regulation to 290 mg/m^2^. A partial response was achieved and PFS was longer than 6 months. Currently, there are no cases concerning regorafenib combination use in third line chemotherapy. The optimal regimens for regorafenib combination therapy are also not known. We used sub group different combination therapy and observed overall survival time. The results are shown in [Table 4](#pone.0190497.t004){ref-type="table"}. 10.1371/journal.pone.0190497.t004 ###### Overall survival time between different chemotherapy treatments in the combination group. {#pone.0190497.t004g} n Mean Std Median ------------------- ---- ------ ----- -------- XeLIRI or FOLFIRI 5 10.6 5.6 10.6 Ufur or Xeloda 7 11.0 3.8 11.3 FOLFOX 1 21.2 Irino 19 10.0 5.6 9.3 Oxaliplatin 2 8.2 5.5 The optimal dosage for combination therapy was not defined. Physicians administered dosages according to a previous study. There were no severe adverse effects noted in the present study after these regimens were combined with regorafenib. The outcome of regorafenib combination use was superior to that of single use. Conclusion {#sec015} ========== Regorafenib combination use with conventional chemotherapy, either single regimen 5-FU, irinotecan, oxaliplatin, or combination regimen FOLFIRI/ FOLFOX, brought superior survival benefit than single use. Side effects were tolerable without decreasing drug compliance. Optimal regimen and dosage of the combination treatment are pending future studies. Supporting information {#sec016} ====================== ###### The file contains the raw data underlying the present study. (XLSX) ###### Click here for additional data file. The present study was supported in part by the study projects of Taichung Veterans General Hospital- CE17123B which was not support from other financial group. The authors would like to thank the Department of Colorectal Surgery and Cancer Registry of Taichung Veterans General Hospital for assistance with data collection and the Biostatistics Task Force of Taichung Veterans General Hospital for data analysis. [^1]: **Competing Interests:**The authors have declared that no competing interests exist. [^2]: Current address: Department of Colorectal Surgery, Taichung Veterans General Hospital, Taichung, Taiwan, ROC | Mid | [
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Micro-electro-mechanical system (MEMS) membrane-type mirrors are well known and may be employed as an economical alternative to conventional deformable mirrors, which for example may utilize PZT (lead zirconium titanate) or PMN (lead magnesium niobate) actuator types. MEMS actuators generally utilize electrostatic attraction to deform the shape of the membrane mirror in a controllable manner. However, in contrast to PZT or PMN actuators, the relationship between the applied voltage and the membrane position with an electrostatic actuator is nonlinear. For MEMS membrane-type mirrors, if the applied voltage is increased beyond a certain value, the electrostatic attraction exceeds the membrane's restoring force, which typically results in a condition referred to as “snap down.” When the membrane comes in contact with the underlying electrical plate (during the snap down event), the resulting spark discharge usually causes the rupture of the membrane. Consequently, to reduce the possibility of snap down, the maximum possible voltage to the actuator is generally limited to a safe value. However, one drawback of this limitation is that the speed and stroke of the actuator is reduced, resulting in a reduced bandwidth or a reduction in wavefront correction capability. Another difference is that the “stiffness” of the electrostatic actuator may be less than PZT or PMN actuators. For example with PZT or PMN actuators, it may be assumed that actuator position is directly proportional to the applied voltage, regardless of any perturbing forces. With electrostatic actuators, the lack of stiffness may result in a greater position error due to perturbing forces, such as for example mirror membrane vibration or adjacent actuator cross-coupling. Position feedback sensing of the membrane is generally required to compensate for the inherent nonlinearity and lack of stiffness associated with the electrostatic actuators. The position feedback sensing is typically performed optically by using interferometers or wavefront sensors that are often expensive and prone to alignment problems. As a result, there is a need for improved techniques for position feedback sensors, such as for example for the MEMS membrane-type mirrors. | High | [
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Q: Convert unicode to ascii I have a text file which can come in different encodings (ASCII, UTF-8, UTF-16,UTF-32). The best part is that it is filled only with numbers, for example: 192848292732 My question is: will a function like the one bellow be able to display all the data correctly? If not why? (I have loaded the file as a string into the container string) function output(container: AnsiString): AnsiString; var i: Integer; begin Result := ''; for i := 1 to Length(container) do if (Ord(container[i]) <> 0) then Result := Result + container[i]; end; My logic is that if the encoding is different then ASCII and UTF-8 extra characters are all 0 ? It passes all the tests just fine. A: The ASCII character set uses codes 0-127. In Unicode, these characters map to code points with the same numeric value. So the question comes down to how each of the encodings represent code points 0-127. UTF-8 encodes code points 0-127 in a single byte containing the code point value. In other words, if the payload is ASCII, then there is no difference between ASCII and UTF-8 encoding. UTF-16 encodes code points 0-127 in two bytes, one of which is 0, and the other of which is the ASCII code. UTF-32 encodes code points 0-127 in four bytes, three of which are 0, and the remaining byte is the ASCII code. Your proposed algorithm will not be able to detect ASCII code 0 (NUL). But you state that character is not present in the file. The only other problem that I can see with your proposed code is that it will not recognise a byte order mark (BOM). These may be present at the beginning of the file and I guess you should detect them and skip them. Having said all of this, your implementation seems odd to me. You seem to state that the file only contains numeric characters. In which case your test could equally well be: if container[i] in ['0'..'9'] then ......... If you used this code then you would also happen to skip over a BOM, were it present. | Low | [
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#import "Globals.h" #import "SeaCompositor.h" #import "SeaColorProfiles.h" /*! @enum k...ChannelsView @constant kAllChannelsView Indicates that all channels are being viewed. @constant kPrimaryChannelsView Indicates that just the primary channel(s) are being viewed. @constant kAlphaChannelView Indicates that just the alpha channel is being viewed. @constant kCMYKPreviewView Indicates that all channels are being viewed in CMYK previewing mode. */ enum { kAllChannelsView, kPrimaryChannelsView, kAlphaChannelView, kCMYKPreviewView }; /*! @enum k...Behaviour @constant kNormalBehaviour Indicates the overlay is to be composited on to the underlying layer. @constant kErasingBehaviour Indicates the overlay is to erase the underlying layer. @constant kReplacingBehaviour Indicates the overlay is to replace the underling layer where specified. @constant kMaskingBehaviour Indicates the overlay is to be composited on to the underlying layer with the replace data being used as a mask. */ enum { kNormalBehaviour, kErasingBehaviour, kReplacingBehaviour, kMaskingBehaviour }; /*! @class SeaWhiteboard @abstract Combines the layers together to formulate a single bitmap that can be presented to the user. @discussion N/A <br><br> <b>License:</b> GNU General Public License<br> <b>Copyright:</b> Copyright (c) 2002 Mark Pazolli Copyright (c) 2005 Daniel Jalkut */ @class SeaDocument; @interface SeaWhiteboard : NSObject { // The document associated with this whiteboard __weak SeaDocument *document; // The compositor for this whiteboard id compositor; // The width and height of the whitebaord int width, height; // The whiteboard's data unsigned char *data; unsigned char *altData; // the cached NSImage CIImage * cachedImage; // The overlay for the current layer unsigned char *overlay; // The replace mask for the current layer unsigned char *replace; // The behaviour of the overlay int overlayBehaviour; // The opacity for the overlay int overlayOpacity; // The whiteboard's samples per pixel int spp; // Remembers whether is or is not active SeaColorProfile *proofProfile; // One of the above constants to specify what is seen by the user int viewType; } // CREATION METHODS /*! @method initWithDocument: @discussion Initializes an instance of this class with the given document. @param doc The document with which to initialize the instance. @result Returns instance upon success (or NULL otherwise). */ - (id)initWithDocument:(id)doc; /*! @method dealloc @discussion Frees memory occupied by an instance of this class. */ - (void)dealloc; /*! @method compositor @discussion Returns the instance of the compositor */ - (SeaCompositor *)compositor; // OVERLAY METHODS /*! @method setOverlayBehaviour: @discussion Sets the overlay behaviour. @param value The new overlay behaviour (see SeaWhiteboard). */ - (void)setOverlayBehaviour:(int)value; /*! @method setOverlayOpacity: @discussion Sets the opacity of the overlay. @param value An integer from 0 to 255 representing the revised opacity of the overlay. */ - (void)setOverlayOpacity:(int)value; /*! @method applyOverlay @discussion Applies and clears the overlay. @result Returns a rectangle representing the changed content in the document's co-ordinates. This rectangle can then be passed to update:. */ - (IntRect)applyOverlay; /*! @method clearOverlay @discussion Clears the overlay without applying it. */ - (void)clearOverlay; /*! @method overlay @discussion Returns the bitmap data of the overlay. @result Returns a pointer to the bitmap data of the overlay. */ - (unsigned char *)overlay; /*! @method replace @discussion Returns the replace mask of the overlay. @result Returns a pointer to the 8 bits per pixel replace mask of the overlay. */ - (unsigned char *)replace; // READJUSTING METHODS /*! @method whiteboardIsLayerSpecific @discussion Returns whether after the active layer is changed the alternate data must be readjusted. @result YES if the alternate data must be readjusted after the active layer is changed, NO otherwise. */ - (BOOL)whiteboardIsLayerSpecific; /*! @method readjust @discussion Readjusts and updates the whiteboard after the document's type or boundaries are changed. */ - (void)readjust; /*! @method readjustLayer @discussion Readjusts and updates the whiteboard after one or more layers' boundaries are changed. */ - (void)readjustLayer; /*! @method readjustAltData @discussion Readjusts the whiteboard's alternate data after the view type is changed. (Also called by readjust.) @param update YES if the document should be updated after the readjustment, NO otherwise. */ - (void)readjustAltData:(BOOL)update; // ColorSync PREVIEWING METHODS /*! @method proofProfile @discussion Returns the selected proof profile, or NULL @result Returns a SeaColorProfile or NULL */ - (SeaColorProfile*)proofProfile; /*! @method toggleSoftProof @discussion sets the color profile for proof @param sender the profile or null */ - (void)toggleSoftProof:(SeaColorProfile*)profile; // UPDATING METHODS /*! @method update @discussion Updates the full contents of the whiteboard. */ - (void)update; /*! @method update:rect @discussion Updates a specified rectangle of the whiteboard. @param rect The rectangle to be updated. */ - (void)update:(IntRect)rect; // ACCESSOR METHODS /*! @method imageRect @discussion Returns the rectangle in which the whiteboard's image should be plotted. This is only not equal to the document rectangle if whiteboardIsLayerSpecific returns YES. @result Returns an IntRect indicating the rectangle in which the whiteboard's image should be plotted. */ - (IntRect)imageRect; /*! @method image @discussion Returns an image representing the whiteboard (which may be CMYK or channel-specific depending on user settings). @result Returns an NSImage representing the whiteboard. */ - (CIImage *)image; /*! @method printableImage @discussion Returns an image representing the whiteboard as it should be printed. The representation is never channel-specific. @result Returns an NSImage representing the whiteboard as it should be printed. */ - (NSImage *)printableImage; /*! @method data @discussion Returns the bitmap data for the whiteboard. @result Returns a pointer to the bitmap data for the whiteboard. */ - (unsigned char *)data; /*! @method altData @discussion Returns the alternate bitmap data for the whiteboard. @result Returns a pointer to the alternate bitmap data for the whiteboard. */ - (unsigned char *)altData; @end | Mid | [
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Q: How to write to /var/log/system.log on a Mac I am tailing the system.log on a mac: tail -f -n 0 /var/log/system.log but I can't figure out how to write to this log. It does seem to be the main log on the machine. I tried: logger foobar # didn't work syslog -s -l error "message to send" # didn't work anyone know how to write to the system.log on a Mac? update: if I run: log stream and then use: logger -is -t krypted "Hello L" it will show up in the stream, but not in /var/log/system.log. weird. A: The streaming messages are part of a binary log file. Apple are moving to a unified logging system, so the logs do not work the same way anymore, at least by default. One might try to configure syslogd and/or ASL (Apple System Logger) via one or both of the configuration files, /etc/syslog.conf and /etc/asl.conf. (There are many more configuration files for ASL stored in /etc/asl.) This might involve grokking manual pages to learn how to produce plain text log files for certain messages. Some of these manuals might be man 1 log, man 1 syslog, man 5 syslog.conf, and man 8 syslog. I have not yet determined exactly how to do this, but I wanted to give you some sort of method to produce, view, and "tail" custom messages. (I'll come back and update this answer if I ever do learn how to send certain messages to a plain text file by configuring their new logging system. It seems that it, at least, can be done, because there do exist plain text files in /var/log.) One can send messages with syslog -s and logger. (The -s option sends log messages to syslogd, and syslog can do more than logger.) An easy way to follow the logs in a similar way to tail is to utilize Console.app. Open the program and place the cursor on the local machine listed under Devices. In the search field, provide the name of the program that was used to send the message: one of syslog or logger. Next, open a terminal and send a message. syslog -s "test message" The message can then be seen in the Console as illustrated below. Messages can be acquired from the logs. Use the --info and/or --debug options to specify lines that log would ignore by default. Specify which process sent the syslog message within the --predicate option. log show --info --debug --predicate "process == 'logger'" or log show --info --debug --predicate "process == 'syslog'" To get an effect similar to tail, use the stream command. log stream --info --debug --predicate "process == 'logger'" or log stream --info --debug --predicate "process == 'syslog'" After starting the stream, send a message to witness that it does behave in a similar way to tail, as illustrated. The command, syslog -s "test message" was used to send the messages. | High | [
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TOMATO: White Pepper Matures late. Plant height upto 200 cm. Fruit color white. Fruit type ribbed. Fruitweight approximately 100g. Taste medium sweet. Crop per plant approximately upto 15kg. The fruits are hollow inside that makes them perfect for stuffing with anything you desire to. This tomato is a hybrid which can still be unstable and the final results may vary. 3,50 € Only few items in stock | Mid | [
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Cole Heppell Cole Heppell (born November 11, 1993) is a Canadian actor. In 2006, he was nominated for a Young Artist Award of Best Performance in a Television Series (Comedy or Drama) - Guest Starring Young Actor for: The Dead Zone: Heroes & Demons. In 2012, Cole was nominated at the 33rd Young Artist Awards for his supporting role as the village fool in Red Riding Hood. He studied at the University of Alberta. Filmography Films |- | |Dear Mr. Gacy | |- TV series References External links Category:1993 births Category:Living people Category:Canadian male film actors Category:Male actors from Calgary | Mid | [
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GREEN BAY – Bashaud Breeland officially is the newest member of the Packers' secondary. Breeland, 26, recorded 270 tackles, 60 pass deflections with eight interceptions (one returned for a touchdown) in his first four NFL seasons with Washington, which selected the 5-foot-11, 195-pound cornerback in the fourth round (102nd overall) of the 2014 NFL Draft. The signing of the fifth-year corner adds another versatile and experienced veteran to Green Bay's defense, which was in the market for a cornerback after Davon House was placed on injured reserve Wednesday morning. Here are five things to know about the Packers' newest addition: 1. He was a four-year starter in Washington Breeland started 58 of the 61 games he played during his four seasons in Washington (including playoffs). His 15 starts in 2014 were the most by a Washington rookie cornerback aside from the 16 started by Champ Bailey in 1999 and Pro Football Hall of Famer Darrell Green in 1983. Breeland made Gil Brandt's All-Rookie Team on NFL.com that season after recording 66 tackles, 14 passes defensed and two interceptions. He has experience playing both boundary and slot cornerback. 2. He always has his hand on the ball | Mid | [
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Guardians of the Galaxy – 2.5 inch figures and vehicles For a second when I saw the tiny little 2.5 inch Guardians of the Galaxy figures in the store, I was thinking “Why would we want something so small, when we are getting them in the Marvel Legends line. Then it hit me. The vehicles. I have been hearing about the vehicles, and they do not disappoint. I have the first two, the Rocket Raccoon’s Warbird, and the Milano. Warbird: Warbird comes out of the box in a few pieces. The main body and the two lower wings. There is also a pack that has two more body parts (which I think are weapons) that attach to the underside of the top wings. The pack also includes Rocket Raccoon as well as a blue Battle Gear with a missile launcher. The Battle Gear come with all of the 2-pack character sets. This is a great looking ship when all together. It looks reminiscent of a Babylon 5 fighter. I really like the design of the double wings. The top set of wings can move up into a battle mode of sorts. It is not a whole lot of movement on the toy, but considering it is 2.5in scale, it is a lot of motion. I was a little bummed when I put Rocket in the cockpit. It is a standard seat for anyone to use. That means Rocket just falls down into a laying position. And he rattles around in there when the ship is flying around. Milano: The Milano comes in a whole lot more parts. Three sets of wings, the canopy, small black engines, 2 missiles, and Star-Lord. There is one more set of wings already attached to the vehicle, which move back and forth. Once together…that is a LOT of wings. On the third wing down moves, though it looks like there will be movement in the top and bottom wings as well in the movie.Those would have been great to see with pivot points. The Milano and Warbird together. The Milano is quite a bit larger. It has a cockpit that seats 3 figures, and features lights and sounds. Gone are the days of including 2 AA batteries. Once supplied, the black button on the back makes a number of weapons and engine sounds. The lights are integrated into the front of the craft making a sort of ‘T’ shape along the front nose of the ship. These are two fantastic ships. I am really happy with these two so far, and I am looking forward to more. 2-Packs Ronan and Star-Lord. This is a different Star-Lord than the one that comes in the Milano. This one is masked, and has on his trademark red trench coat. Ronan is all suited up and ready for battle somewhere. Each 2-pack comes with Battle Gear, which consists of a missile launcher, and a sheet of weapons similar to the weapons packs in the Teenage Mutant Ninja Turtles sets. These however go on the ships. All except for Ronan’s hammer. The missile launcher that comes in this pack does not fit on the Milano or the Warbird. And that is surprising, since there are about 30 ports between the two ships. This is a good pairing of Drax and Korath. Two larger than life strong-men. They come with a green Battle Gear, and a rocket launcher that matches the launcher that comes with Warbird. I am so impressed with the details of these small figures. Well done. Groot and Rocket, together again as one character. Rocket doesn’t have any articulation, so he is more of an accessory. This is the same Rocket that comes with the Warbird. I could see the need for a whole bunch of Nova Corps Officers, but too bad we don’t need extra Groots or Rockets. Overall, I am ecstatic about these figures. They are small, but very well detailed, and even come with some articulation to fit into ships. The two ships are equally as impressive with details and moving parts. I would like to have seen some weapons for these characters to hold. Little guns at the very least. I can see this moving to a whole new world of Marvel figures for Hasbro. They can go a long way with this scale. It would be impossible to make vehicles for the Marvel Legends size figures, and it would even be a bit large for the Marvel Universe scale. Those guys are about the size of a GI Joe, and they have really big cars and planes. At this scale, we can see more of a variety. I wouldn’t be surprised if Hasbro wasn’t a little sad that they didn’t have this scale with the Avengers movie. We could have had Shield cars, motorcycles, jets, and then of course, leading up to the Heli-carrier. Well, they have this scale now, and we are leading up to Avengers 2. Let’s keep going with this scale. And of course, as always, there are LOTS more pictures on my Flicker page. | High | [
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Tyson started ducking and weaving the lasers, his armor heating up due to the near misses of the lasers. The snake swung it's tail and Tyson dived under it, receiving scratches all along his armor and a cut to the back of his head. Getting up and turning to the snake; Tyson flipped his gun to full auto and sprayed for three seconds before ejecting the magazine with rounds still left in it. Tyson watched as the bullets deflected and bounced off the snake and didn't bother with catching the magazine and instead loaded another as he started to run again. Tyson then saw Rowan fire a beam at the snake and destroy a turret after being hit. Brian then healed his wound before hiding behind a tree. Okay he can fire beams at it and he had said he can blast through 12 inches of steel with a beam. I can make that work. Brian's power that he didn't reveal was that he can heal people. I'd rather have him have come out about that power earlier. As Tyson finished that thought the tree got hit by a couple of lasers and started to run towards the tree's previous location. While heading over there Tyson looked back behind him to see the light user, Steven, stop the lasers and deflect them. This is starting to look good. Beyond Steven was a man dressed as a ninja throw three shurikun and Eric launch dirt spikes at the snake. I'll need to know more about their powers before I get a plan in motion but for now we need to regroup. Tyson let out an extremely loud screech at the snake hoping to confuse any potential audio sensors in it before shouting, "Everyone regroup! If we split up we'll only loose! We have to work together!" Tyson reached the location where the tree used to be hoping to find that Brian guy alive. Taryn laughed quietly at Levi's comment but kept her gaze trained on the fight. She hadn't planned to do much more than store the footage and data. But doing some sort of mashup for Christmas time review sounded like it could be fun. Taryn minimized several windows and hit two command keys to make the video feed change display modes. Multicolored lines began to trace objects and alphanumeric characters blinked into existence. Taryn looked up to compare what she was seeing on screen to what was occurring on the field. The reflected laser bolts sent at the MechaSnake by Steven hit a few of the turrets that had targeted him. The nonlethal energy blasts fried and melted the turrets, rendering them inoperable. At the same time Steven's reflected laser bolts hit the snake, Tyrell's throwing stars bounced harmlessly off its glowing red eyes. A few laser turrets targeted Eric's dirt spikes, vaporizing all but one. The remaining spike embedded itself in the thinner part of its cobra-like hood, sending sparks and bits of severed wire flying from the 'wound'. The scream sent its way by Tyson caused the MechaSnake's audio detection instruments to overload, temporarily rendering it deaf and throwing off its targeting system. Despite its sudden handicap, two of its remaining operable turrets immediately took aim and fired at Eric while another shot at Tyson and Brian. Brian was so worried about his poor performance on offense that he forgot to play on defense. The bolt came flying right at him and he had no time to move. Oh f-AAAAAAAAAAAAAA! The laser scored a direct hit on his left leg, blasting a huge chunk out of it. He tried to stand but it was barely hanging on, and he let the world know it. "FUCK! OH FUCK FUCKING OWWWWWW GOD DAMN IT! MOTHER FUCKING AHHHHHH! Fuck. Fuck. OK. OK. Let me se-HOLY FUCK! OH FUCKING SHIT! OH GOD! FUCK! Fuck. Fuck. Fuck. OK. OK. OK.....OK. OK it should be fixing though. It should be- Oh fuck it still looks bad. But I guess it is working. Aw Fuck man!" It was healing though. The flesh and bits of bone slowly started regenerating itself as he kept his leg as still as good. It slowly but surely grew back. The whole process took about 30 seconds but after it all, his leg was back as it was before, good as new. "Fucking hell, man! That, ah! Man god damn! God and now the bloody things asleep. Mother...Damn." He tried walking over to where Tyson was, it took a second to get the feeling back in his leg, but it came back soon after. He made it to Tyson. "OK. I'm good, I think. So, someone want to take that fucking thing's other lasers out?" Eric yelped out in pain. "Fuck." he said as he tried to avoid the shots but one hit him in the ankle and the other in his leg and headed over to Tyson and held his leg. "This is like when I got stabbed in the foot." he said sighing. "God." he said. Alex laughed some watching the new recruits struggle with the snake as she takes another PP!. "Wow this has some kick to it." she said still not a big fan of the bleach but was starting to like it a bit more. Constructing a giant shield around himself, Steven ran over towards Rowan, throwing him over his soldier, while ignoring his prostests. "If I die saving your ass, I swear I'll fuckin kill you," he screamed while dodging lasers. "Shit there's too many to reflect! We need cover...HEY! Eric! Make us some cover NOW! I'll armor it with a shield!" Eric blinked and quickly put his hand on the ground. Using the dirty he turned it into an obsidian dome leaving behind a ditch where the dirt once was. "There that should give us some cover for the time being." he said not quiet sure of what to do next. Alex raised an impressed eye brow. "When did he learn that? Much have been when I was gone. Wounder where he meet an alchemy teacher." she asked her self. She adjusted her setting position some to get a better view of what was happening. "Hmmm seems they may be getting this training after all. Better then my group did." she added. As the dome rose, Brian finally noticed the source...and the injury. "Oh shoot man, you got hit too? Man darn thing's taking target practice on us. Here, hold on for a second, and don't move, OK? Very important you don't do that." He looked down at where the shots were. "Ugh, man. Well at least they got you small and clean. Not like me. All right, like I said, hold still." Brian put his hands over Eric's wounds and concentrated for a few seconds. He could feel the holes closing up, it went a lot quicker for little holes like this. He couldn't be sure how Eric was feeling, but he figured it wouldn't be anything pleasant. Once he was satisfied he lifted his hands and the leg was healed. Jason looked on at the battle, almost completely engaged in the battle. "They're doing...pretty well. I'm surprised." He said, impressed at their advancements in teamwork. Picking up a Patriot Punch-filled coconut, Jason relinquished a small sip from the cup, immediately going into a coughing fit as a result. "Fuck, this stuff is strong." He murmured, taking a sniff and quaintly having his nose hairs burned after. "Well, nail polish and bleach does that." Erebus answered simply. As Jason began to wash down the bitter taste of the drink with soda, he heard Alex's iteration of the fight. "Well, that's about right. Excluding Taryn, and Levi, the last year's rookies were damn mediocre...if I haven't stressed that enough..." He replied to her, quickly downing the soda before going to another. "That's what you get for drinking when you're underage Jason," Garrus lectured to the younger man, shaking his head as he grabbed his seventh PP! and gulped it down. "I will say I do enjoy your list...it makes me laugh," he added as he giggled a bit, the PP!s clearly starting to affect him now as he watched the ongoing fight against the MechaSnake. "Oh c'mon Garrus, i'm like, two years away from the legal drinking age. Besides...that stuff's like poison. I'm surprised no one hasn't keeled over yet." Jason debated back to Garrus before he was practically drowned by Alex. Jason casually shook the access water from him with a smile before finishing his current can of (now watered down) soda. "Well yeah, but you were like, a strung-up bitch starting out. Like seriously, I was a little scared to approach you or Kin because I'd think we'd end up fighting because I coughed the wrong way. So yeah, you've a vital part to the team now, but when you first started out...ehhh, not so much. I'm just saying." Jason replied, adding his own little disclaimer at the end to avoid any serious backlash. "Well, i'm sure you too would be a lot happier if you and your significant other became 'Nympho Buddies for Life'." Erebus gibed with a snicker. Levi nodded in approval at the new recruits' performance thus far. They seemed quick to form plans, to cooperate. It was nearly the polar opposite from what had happened with his own group last year. Save for a few, his fellow recruits were immature, irresponsible, confrontational, and refused to work together as a team. If it weren't for Taryn, Alex, and himself, their group would've been a complete and total bust. Watching the battle, Levi watched as Eric erected his fellow recruits some temporary shelter. "I wish the others were this cooperative during our training exercise," he said to Taryn. "They're getting the hang of it pretty quickly..." Observing that its targets had erected a barrier, the MechaSnake focused all available firepower and fired upon the recruits' temporary shelter. However, with its nonlethal armaments, it was not making very much progress. The mechanical serpent's sensors analyzed the the dome that kept its targets out of its reach. It was made of obsidian, a relatively brittle material. As a result, the MechaSnake opted to go for a more direct option. The giant machine swung its tail and used it as a blunt weapon, smashing off a significant portion of the obsidian dome and exposing its occupants. It took the opportunity offered and aimed all available turrets down into the hole and began to charge them for another volley of shots. "Huh, yeah, and who was it that was sorting out most of the fights?" Katie asked before raising her hand with a grin. "Hell, I took a freaking lightning bolt for Alex once. Kin was far too unreliable and volatile to be an effective part of the team. Plus she had her daughter running around - another concern of mine - and neither of them were within the acceptable age limit for applications, if I remember correctly." "You arse! I could have handled myself perfectly fine," Rowan yelled at Steven before the MechaSnake smashed the dome down. "Oh, son of a..." he murmured as he realised that the mechanical monstrosity had them trapped inside the open-air dome. Thinking quickly, he ducked into what little cover was left, and shifted into Brian's appearance as he had planned, then stepped out into the open. Hopefully the identical copy would confuse the MechaSnake into targeting Rowan rather than the near-defenceless healer. Tyson watched as most of the team had gathered together and make a temporary shelter for themselves. Okay. I think I have a plan that isn't total suicide. As soon as that thought finished the top of the shelter got smashed off and the snake could be seen charging its beams. Tyson screeched again then turned back to the group and barked an order to Steven, "Make a light shield and deflect the beams around the dome." Tyson then went back to his previous thought started to speak. "I have a plan. It isn't as suicidal as it sounds and it could easily work. Eric I'm going to need you to change the medal armor on the snake to something weaker. We can then blast through the armor and that's going to be the easiest way to get to the hardware and shut that machine down. For this to happen we'll have to distract the snake from attacking Eric. Steven, Rowan, and myself will have to distract it. Brian we'll need you to stay back and move in when we get injured and heal us." Tyson finished the rant and let out a deep breath. "Once the snake fires drop the dome and disperse. Eric pick your timing carefully and lets do this." Tyson finished speaking and waited for the next attack. I hope this plan works. Actually this plan will have to work. The second screech from Tyson once again sent an overwhelming amount of audio feedback through the MechaSnake's audio sensors. Unable to compensate for the second overload, the machine's targeting system was significantly scrambled, leaving it unable to fire accurately for a few more seconds. Externally, the only sign of anything being wrong was the fact that it now seemed to hesitate. Levi watched as the MechaSnake seemed to...freeze in place. Glancing over at one of the windows on Taryn's screen, he could see a new fluctuation of data begin to scroll across. He furrowed his brow. Whatever it was, it couldn't be good. "Er...Taryn? I'm not sure what to make of all that, but it can't be good," he said, his eye still on the rapidly scrolling stream of characters. "Great. OK. I can do distraction," Steven muttered to himself. Bracing himself against a wall, he faced the giant snake and constructed a solid dome around its head. "He's blind, but not forever." Looking back over at his new partner, he asked quickly, What's step two of this plan of yours? Please tell me it involves a giant 'off' switch." "Aw...frak" Taryn muttered quietly as she rapidly minimized and maximized windows. She skimmed the lines that were appearing and automatically translated them. "Well they managed to mess up the sensors a bit..." she said. Out of habit Taryn hit the side of her computer lightly, as though it would 'fix' the dark red text. "As he said, we wait for Eric to do something to the armour. With luck it'll be weaker, and we can damage its internal mechanisms," Rowan answered in Brian's voice. "Oh, er... this is Rowan speaking, just so we're clear." He shot another psychic bolt from his fingers to prove it, smashing a human-sized piece out of the obsidian dome. Huh. Seems it breaks easily, he thought, noting that the strength of the blast he had used was nowhere near enough to make a hole that large. Figuring that it would be easier to have multiple holes from which to leave, rather than just the one, he proceeded to shatter the breakable wall in two other places, allowing everyone to scramble out from different exits. "It looks like the snake has to charge up its turrets before it fires. After it attacks us again I'll head out through the hole on the right, and try to take out a couple of the turrets as I go. Brian, you should head the other way if you're gonna go someplace. Don't worry about healing me up, I'll be fine after I shift back. Concentrate on the others more than me." Alex shrugged. "Yea I was a bitch then but Richard helped calm me down. Well so did my time in Tibet but hell what I was then isn't what I am now. Now I'm far less likely to even hit someone unless they truly have it coming." She said to Jason calmly then looked at Katie and Levi. "Katie, I have to thank you for that. Kin would have killed me with that bolt and she almost did with what she hit me with. As for what's fighting the snake now, well I think we got a good bunch this round. Eric seems to be doing better then I expect from him." Alex said crossing her arms. ---------------------------- "Just let me get close enough to the snake I can make it tin easy." Eric said nodding and getting ready for the fight as he redid the done and adding more layers. Dodging another savage swing of the beasts tail, Tyrell prepared to heed his fellow heroes call to retreat, for they were certainly not getting anywhere attacking all on their lonesomes. The Shadow's shuriken had proved useless against the mecha-snakes armored hide and simply pinged off harmlessly, if Tyrell wanted to have a chance at defeating the creature, he'd have to Chi-strike it, the only problem was getting close enough to perform the maneuver. 'Problem solved' thought Tyrell, his body already moving towards his destination with nigh-supernatural speeds. For The shadow had identified how he was going to dodge the creatures swings for long enough to be able to strike it. Jumping up upon one of the dirt pillars one of his fellows had created, The Shadow had only a few seconds to get his bearings upon it, before the snake demolished it with its ridiculously powerful armaments. Leaping to another pillar, Tyrell again had only a few seconds before that second pillar was annihilated. However, as they say, the third pillar was lucky, as it had impaled the snake and just as Tyrell landed precariously upon it, The Shadow knew he would strike the killing blow. The Ninja closed his eyes and leapt towards the snakes turned head, focusing all his consciousness and being into his right fist, the fist that he swung forwards toward his foe with such immense speed the air around it seemed to ripple. The light shield surrounding the head of the MechaSnake made it impossible for the machine to attain a target lock on the trainees. For all intents and purposes, it was blind. Tyrell's strike connected with the side of the MechaSnake's 'head', causing a significant dent in the metal armor and destroying one of its eyes in an explosion of glass and sparks. The mechanical beast began swinging its head back and forth violently, launching Tyrell into the air. Its motion sensors still functional, the snake was able to aim a swing with its tail, slamming it into the airborne man like a baseball bat. The impact sent Tyrell flying into the freshly restored obsidian dome, shattering it instantly. Levi furrowed his brow again as the live video feed from the MechaSnake suddenly became flooded with bright light. He looked up from the screen to the battle in the distance and saw that a light shield of sorts had been created around the machine's head, rendering it blind. "Smart move," he said aloud. Levi watched as Tyrell landed a powerful blow into the side of the MechaSnake's head. One of the windows from the video feed abruptly cut out into static. Going for the optics. Very nice, but that's not all this thing has. He winced a bit when he watched the snake send Tyrell flying into the dome the recruits had constructed. Training exercise or not, that has to hurt. Tyrell was already unconscious by the time the snakes tail slammed into him, cracking atleast two of his ribs. The immense force and concentration required by the Chi-strike always meant the practitioner of the attack would suffer some after effects, from mild drowsiness to unconsciousness, The Shadow was currently among the latter. For while he had trained for many years up to this moment, he was still not a true master and his skills were still developing, so until he had trained his skills further, the Chi-strike would most likely have the same effect on his each time. But as long as his team-mates eventually beat the snake, everything would be worth it. It was part of his philosophy, 'always look at the bigger picture and the end justifies the means, even when people were hurt'. The dome exploded over Tyson's head as the last new recruit dressed as a ninja went flying through the obsidian cover destroying it. "It starts now people lets make this plan work!" Tyson shouted switching his gun to semi auto and firing three shots at the snake's body before running out to the right firing a shit every few steps. Tyson then looked up at the snakes head noticing someone had bashed part of it in. Okay, that's impressive. I hope they have a video of this so I can see how he did that. The snake then swung it's tail low at Tyson causing him to jump. The tail lifted and struck Tyson's legs cracking and breaking off some of the armor as Tyson fell to the group. Still determined to keep the distraction up, Tyson fired blindly lifting himself off the ground. As Tyson started to run, extreme jolts of pain went straight up his legs almost causing him to fall over again. "Brian, get Tyrell out of sight," Rowan yelled to the healer, noting the snake's wild thrashing around. He broke left in the opposite direction of Tyson, moving to circle around the snake and attack it from behind. He launched the occasional bolt up at the snake's armour, but the attacks had little effect other than leaving a small scorch mark on the metal. Evidently the armour was much tougher than the turret he had taken out earlier. "It's nothing, Alex. You'd have done the same for me in a different situation," Katie answered, waving her hand as if to brush the comment aside. She sat up from her position on the hedge-couch, picked a soda out of the basket and opened it. Judging by the recipe of Patriot's cocktails, she was never going to even think about touching those. Nail polish remover and bleach... the latter at least was poisonous to regular humans when ingested. "They seem to be doing pretty damn well, at least better than they were before," Garrus said with a slight slur, deciding that he had had enough PP!s and laid down on the blanket. "They are doing spectacularly! They seemed to have come up with a plan, oh golly I hope they beat it. We haven't had the snake be actually beaten in awhile. Ohhh and then if they aren't roughed up enough I can join in!" Patriot said excitedly, jumping up and down and clapping his hands."Probably not Patriot...the last time we actually participated the new recruits weren't that roughed up and didn't learn the lesson but these guys are already doing much better," Garrus replied back to the excited Patriot. "Aww but I want to beat up the noobs." Alex laughed some finishing her last PP! and sighed figuring she should not have any more and tossed the PP! aside breaking it in half with a whip of water from her finger tips. --------------------- Eric took his chance to sneak behind the snake then jump on it's back putting his hands on the snake starting to turn it into tin. He knew he'd need sometime to fully change the snake over to tin. He's only hope was that the rest of his team could hold it off for long enough. He made some of the metal wrap around his legs and arms so he couldn't be throw off but if he was hit or the snake rolled over he was fucked. Taryn glanced over at the enthusiastic Patriot. As she turned back to her computer, she whistled quietly at the new data that began to appear. Then a new window appeared with a few short lines of text. Taryn looked out onto the field to see Eric had welded himself to the snake. "Uh oh..." she mumbled. She looked over at Levi and somewhat calmly asked. "The Doctor is in, right?" On the field, the MechaSnake continued to writhe and toss its head almost angrily in an attempt to regain its optical sensing capability. The outer layer of armor beneath Eric's hands began to transmute from a darkened steel alloy to shiny tin. The transformation spread slowly. When the two areas beneath Eric's hands spread enough to combine, the snake's electrical defenses kicked in. As part of the upgrade process Taryn had designed, programmed, and designated 'Static Shock'. Which was a defense mechanism designed to cause neuromuscular incapacitation. Beneath the layers of armor, thousands of thin metal wires were connected to individual circuits which, when the first phase activated, sent a series of high-voltage low-current electrical shocks up to the surface of the snake. Anything that was in contact with the snake at the time of activation was immediately, but temporarily, paralyzed. The second phase of the attack was a much stronger jolt that only activated if the snake continued to detect contact with its surface after a set period of time. The second phase boosted the voltage and amperage of the electricity to render opponents unconscious. Taryn had tested both phases herself, but due to her own electrical powers she had not experienced the full effects of either phase. Levi had been with her for the testing as a safety measure. Taryn had noted at the time that he backed up when she tested the second phase. As Taryn focused on the combatants and the MechaSnake she lowered her computer to her side. Unwatched, and unnoticed, two new lines appeared. Raw electricity flowed up through the snake's armor and spread out to every square inch of its outer surface. The areas of the MechaSnake that were tin slowed the current a mere millionth of a second. Strapped as he was to the snake, Eric's body was subjected to enough electricity to render a superhuman unconscious in the span of a millisecond. "Right, doing that!" Brian replied as he moved over to where the "ninja" had landed. He hadn't really talked to him...or seen him for that matter, but if they were on a team, he would get him moved. It was a shame he could only heal physical wounds. Restoring consciousness was out of his grasp. "Come on, bye. Here we go." He picked him up and draped him over his shoulder, bracing him with his hockey stick. Spotting the hole that Eric had created when he made the dome, he decided that place was as good as any at the moment, and after making his way there, he slowly lowered him into the trench. "OK, there, now you just wait until Eric finishes with the-" As he looked up he saw sparks shooting from the spot where he assumed Eric was. "Oh...oh shit, that can't be any kind of good there." Tyson watched in horror as his plan backfired. Not only did the armor basically remain unharmed but it had an unforeseen defense that electrocutes people. It's been a while since physics or chemistry but I think this will work. Adrenalin started pumping as Tyson opened his mouth to the size of what a person normally would to whistle and started emitting sound waves at Eric. Tyson was increasing the frequencies rapidly looking for any vibrations of the tin. The tin vibrated for almost an instant and Tyson barely saw it. By this point a ringing filled Tyson's ears but he started going back over the frequencies he just passed at a slower speed until the tin started to vibrate rapidly. Tyson increased the decibel level causing the vibrations to intensify and break the tin off from the snake's armor. As Eric fell to the group Tyson called out, "Someone get him and bring him back to Brian!" Tyson then started firing at the snake's hoping to draw it's attention so the retrieval could be successful. The previous ringing started to clear out and fatigue started to become more apparent to Tyson. I'm not going to last much longer than this but at least I won't wake up with a nasty headache like Eric. Tyson laughed a little to himself before switching mags. Richard was simply sitting back and watching chaos reign as the newbies tried to fight the snake. "I honestly hope they don't beat the snake. Last time anyone did it did not end well, but it seems they are learning the lesson so unless Garrus just wants to pummel the crap out of the new guys we probably won't have to resort to plan B." He said as he had switched from patriot punches which were honestly pressing his nanites to the limit to keep him from dying to soda to hopefully balance the pH a little. ----------------------- Lillian was sitting back and watching without a word, the recruits were doing far better than she had expected considering the stories she had heard of the last batch. She made sure to keep an eye on Renton as he started to wander a bit after he had gotten used to Patriot's presence. "Hey you two," Garrus said as he got up and stood next to Levi and Taryn, holding his aching head as he continued watching the fight, "I think they've done pretty well already. I'd say give it a few more minutes before turning off that snake...rather not have anyone too injured since we'll probably celebrate with a pool party once the Doctor fixes up the injuries. AND YOU STAY THE HELL AWAY FROM HIM!" Patriot immediately stopped chasing after the teary-eyed Renton, having been trying to get the child to come to him before starting to go after the kid a bit too enthusiastically."It's all good Garrus! See? I'm backing away from him now...we'll have to take a rain check on me flying you around kid," Patriot whispered as he slowly backed away from the toddler, taking a seat back down on the edge of the picnic blanket and taking a sandwich out to eat. "I'm watching you," Garrus said before turning back to Levi and Taryn, "So yeah...anyways." Alex looked at Richard. "I can't say I agree with you Richard but I see your point. I want them to go through what I had to." Alex said softly kissing Richard's cheek then looked at Garrus. "Ah yea a pool party, sounds nice. Hey remember the beach? Man that was a good time. I was the only woman there and trust me I didn't mind but there's no fucking way I'll do it again." she laughed some thinking about it and sighed. "But I will beat the crap out of that idiot the next time I see him." she added. Rowan aimed one hand at the shinier tin of the snake's armour, launching another psychic bolt up at it as he ran around the back of the snake to grab Eric. He dragged the transmuter a few metres away from the monstrosity, before he carefully lifted Eric up and over one shoulder. With that, Rowan began to jog back to the hole in the ground, careful not to jolt or bump Eric as much as possible. "Another one for you, doc," he grunted under Eric's weight before setting him down on the ground beside the unconscious Tyrell. | Low | [
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The case of the disappearing (space) dinos The spacedino story continues to develop. Yesterday the ACS issued a statement to Nature’s newsblog, “We are following established procedure to investigate the claim of self-plagiarism. If it is determined that this is case of self-plagiarism, appropriate action will be taken as provided for in our ethical guidelines.” So at least ACS are appearing to take action. Although judging from comments on a variety of blogs and twitter many of use were pretty skeptical that any real action would be taken. Then ACS pulled the pdf of the paper! You can still see the title and citation details. But the pdf has been replaced by the message. This article was removed by the publisher due to possible copyright concerns. The Journal’s Editor is following established procedure to determine whether a violation of ACS Ethical Guidelines to Publication of Chemical Research has occurred. Its interesting that in one statement the ACS says it is “investigating the claim of self-plagiarism” whilst the other just refers to “copyright concerns”. So what happens next? Paul at Chembark has pointed out that this is rather an odd step to take. He argues that an addition or correction aught to be published, as is the norm when a paper turns out to have errors. But this case is somewhat different. After all the copyright for the paper belongs to the Isreal Journal of Chemistry or as it now transpires Tetrahedron letters (where, it turns out most the article was originally published). So ACS had little choice but to pull the PDF (and I hope the IJC do the same). Its not like the ACS swept the whole thing under the carpet. They haven’t removed all evidence of the paper, you can still see the title etc. and the statement that remains is a pretty clear. Since Breslow is the only author of the paper, he is clearly being blamed for the infringement and the accusation is right there for everyone to see. I don’t think this should be the end of the matter. Paul’s excellent reaction to the self-plagiarism allegations suggested two actions from ACS: A retraction of the paper (done) and an updated press release. We are still waiting for that public facing reaction and I hardly think the statement to Nature or the comment that replaces the paper are adequate. This invited Perspective was withdrawn at the request of the author due to similarity to his previously published reviews, specifically those in Tetrahedron Letters and the Israel Journal of Chemistry. The author stands by the scientific findings and conclusions as published in those reviews. The Journal of the American Chemical Society and ACS are investigating allegations of self-plagiarism leveled against Columbia University chemistry professor Ronald Breslow. ACS, which publishes C&EN, says that appropriate action will be taken by the journal if the society’s ethical guidelines have been violated. At this time, the paper has been removed from theJACS website. The paper concludes with speculation that life-forms elsewhere in the universe could be based on ᴅ-amino acids and that those life-forms could be advanced forms of dinosaurs. A media alert on the paper from the ACS press office on April 11 focused on this speculation. Some news outlets printed or posted stories based on the press release while a number of blogscriticized the release as being scientifically naive. More seriously, as various individuals commented on the blog postings about the press release, one person noted similarities between Breslow’s JACS Perspective and a paper Breslow had published on the same subject in Tetrahedron Letters in 2010 (DOI: 10.1016/j.tetlet.2010.08.094). Subsequently, Stuart Cantrill, chief editor of Nature Chemistry, pointed out in his personal Twitter feed that the JACS Perspective was identical in largepart to a review Breslow had published in 2011 in the Israel Journal of Chemistry (DOI: 10.1002/ijch.201100019). A number of chemistry-oriented blogs such as In the Pipeline andChemBark subsequently weighed in on the controversy. “We take allegations of plagiarism, including those of self-plagiarism, very seriously,” says Brian Crawford, president of the ACS Publications Division. In this instance, Crawford explains, it was determined that Breslow’s JACS Perspective should be removed from the ACS Publications website pending resolution of editorial and copyright concerns. The following notice currently replaces the article’s full text content: “This article was removed by the publisher due to possible copyright concerns. The Journal’s Editor is following established procedure to determine whether a violation of ACS’s ‘Ethical Guidelines to Publication of Chemical Research’ has occurred.” University of Utah chemistry professor Peter J. Stang is the editor of JACS. Breslow did not respond to C&EN’s request for comment on the matter. Breslow is a titan in the chemistry enterprise and a major figure at ACS. He served as the society’s president in 1996 and was the recipient of the society’s highest award, the Priestley Medal, in 1999. He is a member of the National Academy of Sciences and a recipient of the National Medal of Science (1991). | Low | [
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Bacon, Peppers and Gruyère Cake I know lots of people who dislike peppers, especially when raw. They could be stodgy and their skin is difficult to eliminate properly when cooked. But this wonderful, tasty cake has made me change my mind on peppers. And I have to say that I’m not the only one who fell in love with it! Christmas holidays mean only one thing: a huge amount of left-overs. Small pieces of this and that linger in your refrigerator for days. No clue how to use them. Well, this cake is certainly a good way to give them a good ending! You only need some Swiss cheese – or gruyère -, bacon and red peppers, previously grilled. The only rule to follow to obtain the best result is using top quality ingredients. This cake is so simple that it really needs the best bacon, peppers and cheese to become unforgettable. I’ve recently made it for a Masterchef-watching night with some friends, and they loved it. Just be sure to warm it a little bit before serving it cut into slices. Bacon, Peppers and Gruyère Cake 4 eggs 2 tbs extra virgin olive oil 1 glass of dry white wine 100 gr. grated gruyère 200 gr. all-purpose flour 16 gr. baking powder 3 red and yellow peppers sea salt black pepper LET’S DO IT! Preheat the oven at 210° C (410°F). Put the peppers on a baking tray and let them roast for about 20 minutes, or until they are puffed up. Then take them out of the oven and put them in a plastic bag. Let them cool completely. This will help you peel them! Cut the bacon into small cubes and roast them in a pan for 5 minutes. Stir the eggs, the wine and the oil in a large bowl. At this point add the grated cheese, salt, pepper, the flour and the baking powder. Gently mix, then add the bacon and the roasted peppers, cut into small pieces. Grease a rectangular mold with butter and pour the mixture in. Bake for 45 minutes. Use a toothpick to test if the cake it’s done. Poke the top of the cake in the middle with it. If it comes up dry, your cake is ready! | Mid | [
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Saturday, June 18, 2011 A Two Years Old Boy Smokes Cigarette Since He Was Four Months A Two Years Old Boy Smokes Cigarette Since He Was Four Months - FaceLeakz - Although he's just 2 years and 2 months old but he already knows very well how to smoke a cigarette is. The boy who started to like the smokes of tobacco is named Choirul Anam. This craze is getting a number of cases of children under five addicted to cigarette in Indonesia. In 2009 a 4-years-old smoker also occurred in the city of Malang. The boy who is named Sandi Adi Susanto, living in residents Kepuh, Sukun District, Malang, frequently cursed when he was smoking. It's Not Cool boy: Sandi Adi Susanto Smoked a Cigarette in Malang At that time, after he woke up, Sandi requested to made a cup of coffee and asked for a cigarette. Unlike Sandi, the case of the third son of Salama, 27, and late Asmad, the residents in Hantuah Gang Nanas street, Ngemplak Village, Gadingrejo Pasuruan District, has been long happened. The boy who nicknamed Irul starting addicted to cigarettes since his age of four months. Within a day, Irul could spend three cigarettes. In front of his new father, Irul does't awkward for asking and lighting his own cigarette penchant. Even when the fire of his cigarette would be turned down by winds, he tried to cover it up his self with a pack of cigarette. Once he lit a cigarette and smoked, the belching smokes went out from his lips.Such as adult smokers, Irul also set up an ashtray that was placed in front of his seat. When the ash started to pile up, he handed the cigarette onto the ashtray. According to Abidin Slamet, 51, who is grandfather to Irul, this bad habit was started from his interest to a cigarette which is left by his grandfather. unnoticedly by his family who worked as a chicken butcher in the Great Market Pasuruan, Irul took the cigarette which is left still in lit. "I left the cigarette in lit condition while I was bathing. Then it was taken and smoked by Irul. I just found it out after I finished bathing. When I asked to return the cigarette, Irul was mad at me," Abidin Slamet said. This issue has captured an attention from Pasuruan health department. They send their team for monitoring the health impact of Choirul Anam. The team also made observations and inventory its handling steps. "We got off to observe and how to handle it," said dr. Hendra Ramadhan of the health department team in Pasuruan. | Mid | [
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Shoulder Pain Tendonitis What is it? Shoulder tendinitis is a common overuse injury in sports (such as swimming, baseball and tennis) where the arm is used in an overhead motion. The pain – usually felt at the tip of the shoulder and referred or radiated down the arm – occurs when the arm is lifted overhead or twisted. In extreme cases, pain will be present all of the time and it may even wake you from a deep sleep. Statistics: As per statistics, 6 out of 10 causes of shoulder pain are linked with supraspinatus tendonitis. According to the survey, statistics show that while women only incurred only 33% of the total number of injuries at work, they incurred 65% of the tendonitis injuries and 61% of the repetitive motion injuries. Important Facts: People at risk include carpenters, painters, welders, swimmers, tennis players and baseball players. The average patient is a male laborer older than 40, and the shoulder pain is on the same side as his dominant hand (for example, right shoulder pain in a right-handed person). Volleyball players are particularly prone to shoulder tendonitis, inflammation of the tendons that support the shoulder. If you have tendonitis, it’s very important to heal it quickly and completely. If you don’t, it may plague you forever. Treatment Duration: Initial recovery is typically within 2 to 3 days and full recovery is within 4 to 6 week. Dos/Don’ts: Rest your shoulder initially, avoiding any movements that cause you pain. Start to do gentle movements as soon as possible to prevent any stiffness in your shoulder. Don’t push through pain. Only use your arm in ways that do not cause more pain. Do not attempt to strengthen the shoulder with push-ups. This has not been found to make a difference and may worsen the pain. Common Myths: The issue we find with cortisone injections is that people get a false sense that they are healing because they are not experiencing the pain they once did. Some individuals even engage in activities they should not be doing because they “no longer feel pain”. Merely masking the pain is not a solution; it is just a temporary fix. Cortisone does not provide a permanent contribution to any stage of healing. It is a myth that tendonitis injury heals completely back to 100% if you just give it time and rest. Tendonitis is really a process that is either going in a Downward Spiral or an Upward Spiral. United States Food and Drug Administration has issued a special warning for all fluoroquinolones, including Cipro (ciprofloxacin), as these medications have an increased risk for tendonitis and tendon ruptures. If you are taking Cipro and experience tendon problems, such as difficulty walking, tendon pain, or weakness, contact your healthcare provider right away. Bursitis What is it? A bursa is a tiny fluid-filled sac that functions as a gliding surface to reduce friction between tissues of the body. The plural of bursa is bursae. There are 160 bursae in the body. Bursitis is inflammation of a bursa. When injury or inflammation of a bursa around the shoulder joint occurs, shoulder bursitis is present. Statistics: The last statistic I looked at I think was from 2003 and there was at that time in the United States 14 million people who suffer from shoulder problems. Important Facts: You may have tendinitis (inflamed tendons) and bursitis in your shoulder at the same time. Your bursitis may be part of a problem called shoulder impingement (im-PINJ-ment). Older age is associated with bursitis, and one of the most common places it strikes is in the shoulder, which has the greatest range of motion of all the body’s major joints. The pain is generally felt along the outside top of the shoulder. The discomfort of bursitis tends to be most severe after a night’s sleep and will typically subside somewhat with normal activity. Other places that are prone to bursitis are the elbows, hips, knees, and the base of the thumb. Keep pressure off your shoulder. You may be told to avoid lying or sleeping on the shoulder with bursitis. You may be more comfortable sleeping on your back. Also avoid activities that make your shoulder pain worse, such as throwing and overhead reaching and lifting. Keep your shoulder muscles strong by doing special exercises. Having strong arm, shoulder and back muscles can help support your shoulder. Your caregiver can help you plan an exercise program to build up your muscles and keep them strong. Common Myths: Bursitis is the most common problem of the shoulder. Reality: The term “bursitis” is often used incorrectly by physicians and patients to describe the most common cause of shoulder pain. Rotator cuff tendinitis is actually the most common cause of this complain. Frozen Shoulder What is it? Frozen shoulder (FS) is a fibrous contracture of the coracohumeral ligament and rotator interval coming on insidiously, or after minor trauma, and resulting in a global loss of active and passive movement especially in external rotation – and in the presence of a normal x-ray! Statistics: Frozen shoulder is a painful, debilitating disorder reportedly affecting 2–5% of the general adult population (Lundberg, 1969) and 10–20% of people with diabetes (Miller et al., 1996). This shoulder joint disorder affects roughly two-percent of the population and up to 20-percent of diabetics. Important Facts: Primary frozen shoulder is classically described as having three stages, with stage I involving pain, stage II pain and restricted movement, and finally stage III, involving painless restriction (Reeves, 1975). Left to its own devices the shoulder will start to thaw and slowly a near normal shoulder will come back. Sadly FS is misdiagnosed some three times out of four. This is a particular error in the older age-group where I regularly find patients in their 70’s and older told they have FS when a simple x-ray would have revealed that they have osteoarthritis or shoulder joint disease and really could do with a shoulder replacement. If you see a 70 year old with a stiff painful hip or knee, you would automatically and usually correctly, think arthritis. It is a myth to think that OA of the shoulder is rare. Frozen shoulder (FS) is a fibrous contracture of the coracohumeral ligament and rotator interval coming on insidiously, or after minor trauma, and resulting in a global loss of active and passive movement especially in external rotation – and in the presence of a normal x-ray! Treatment Duration: Most cases resolve over the course of 18–30 months. However, a minority of patients have a protracted course with ongoing restriction. Do’s/Don’ts: It was only later when I read Doctor Cameron’s book that I discovered that exercises too early in the frozen shoulder situation can actually aggravate things. It seems that the best time to do exercises is near to the end of the business – when the frozen shoulder is in its thawing out stage. Of course, there was no way for me to know that so I just assumed that I must be making a meal of it and tried to just plod on as normal. Once the diagnosis has been made – restricted passive external rotation and a normal x-ray – I offer my patients two alternatives: they can sit it out in the knowledge that it will all get better eventually or I can accelerate their recovery by doing an arthroscopic capsular release. Common Myths: In the early stages FS and tendonitis can be indistinguishable. If the examining physician doesn’t actually try and move the arm themselves then they could believe that the shoulder doesn’t move but that is only because the patient doesn’t want to lift it any higher. Then a diagnosis of FS is made, a steroid injection is given and the symptoms all go away. Thus steroid injections cure FS! Impingement Syndrome What is it? Impingement Syndrome, which is sometimes called Swimmer’s shoulder or Thrower’s shoulder, is caused by the tendons of the rotator cuff becoming impinged as they pass through the shoulder joint. Statistics: According to the Bureau of Labor Statistics (BLS) 2003 Survey of Injuries and Illnesses, in Texas, while back injuries are the most frequently reported on-the-job injury, shoulder injuries kept people out of work the longest—30 days compared to the back—12 days. Published rates of the incidence and recurrence of shoulder pain are as high as 80% in competitive swimmers in the US. Important Facts: In selected patients, chronic neck pain may be caused by shoulder impingement, which can be easily diagnosed with standard techniques. The difficulty in making this diagnosis is that the patient presents with neck pain rather than with the typical shoulder pain. The differential diagnosis of chronic lower neck pain should include shoulder impingement syndrome, which can be identified by classic physical and radiographic signs and can be treated with injection into the subacromial space and avoidance of the shoulder impingement position. Dos/Don’ts: TRY HARD TO STAY OUT OF STRESSFUL SITUATIONS! When your muscles tense up, your pain will increase! It’s a fact! A very sad fact, but a fact none the less! I cannot stress how much you need to stretch in the morning as soon as your pain medication begins to work. Because if you don’t, when you don’t have any pain medicine, it will be harder to stretch the way you need to. Don’t Wait To Go See a Doctor! I waited about 4 or so days before going to the doctor. THAT WAS TOO LONG! By then my right arm was basically useless, not to mention I was in such pain I was in tears. I was given some pain medication and it said take with food or milk. Common Myths: Softball Pitching Myth Busted! For years, we’ve heard that the windmill pitching motion is natural and safe for the body unlike the overhead throwing motion that baseball players use. More and more research studies are showing that the incidence of pitching injuries in softball is pretty much the same as in baseball. In fact, the studies are showing that the windmill pitching motion is very tough on the body. Myth: During a lat pull-down, you should pull the bar behind your head and to your upper back. Reality: “This can lead to shoulder impingement syndrome, a painful condition that injures muscles, tendons and the shoulder joint. Pull the bar in front of your head to the top of your chest.” Dislocation What is it? If your shoulder is wrenched upward and backward, you may dislocate it out of its socket. This condition is both painful and incapacitating. The force required is often that of a fall or a collision with another person or object (both of which can occur during many sports). Statistics: But even with physical therapy, for patients that are less than 25 years of age and are going back to high level sports, collision sports, contact sports, their chance of a recurrent dislocation is Important Facts: The main symptom of a shoulder dislocation is severe pain at the shoulder joint. The patient will have great difficulty moving your arm even a little bit. If the shoulder is touched from the side, it feels mushy, as if the underlying bone is gone (usually the humeral head – top of the arm bone – is displaced below and toward the front). Treatment Duration: Treatment may include medications to lessen pain. After a dislocation is confirmed by x-ray, many people require medicine to lessen pain and help relax the surrounding muscles during the reduction procedure (relocating the joint to its healthy alignment). The patient may require a mild sedative as well to allow the body to relax. Most people can have their dislocated shoulder relocated in the emergency department, but a few difficult cases require a general anesthetic in an operating room. Dos/Don’ts: If a sling is not available, rig one by tying a long piece of cloth in a circle (a bed sheet or towel may do nicely). A pillow placed between the arm and body may also help support the injured shoulder. Because an empty stomach is best during treatment, the patient should not eat more than ice chips before being examined by a doctor. Common Myths: If you have dislocated your shoulder or another body part, a simple snap will not automatically put the joint back in place, regardless of what TV sitcoms suggest. Instead, ice the injury and seek emergency attention. Subluxation Problems What is it: A shoulder subluxation or instability involves a temporary, partial dislocation of the shoulder joint. A partial dislocation (subluxation) means the head of the upper arm bone (humerus) is partially out of the socket (glenoid). A complete dislocation means it is all the way out of the socket. Both partial and complete dislocations cause pain and unsteadiness in the shoulder. Statistics: Over 95% of shoulder dislocation cases are anterior. Important Facts: A shoulder subluxation usually occurs in one of three types of patients: those with a prior injury to the shoulder, those who overuse their shoulder, and those who are double jointed. What are the symptoms of shoulder subluxation? Symptoms of a shoulder subluxation include the feeling that the shoulder has gone “in and out of joint”, “looseness” in the shoulder joint or, in some cases, pain, weakness or numbness in the shoulder or arm. Treatment Duration: The doctor will place the ball of the upper arm bone (humerus) back into the joint socket. This process is called closed reduction. Severe pain stops almost immediately once the shoulder joint is back in place. Dos/Don’ts: Your doctor may immobilize the shoulder in a sling or other device for several weeks following treatment. Plenty of rest is needed. The sore area can be iced 3 to 4 times a day. After the pain and swelling go down, the doctor will prescribe rehabilitation exercises for you. These help restore the shoulder’s range of motion and strengthen the muscles. Rehabilitation may also help prevent dislocating the shoulder again in the future. Rehabilitation will begin with gentle muscle toning exercises. Later, weight training can be added. If shoulder dislocation becomes a chronic condition, a brace can sometimes help. However, if therapy and bracing fail, surgery may be needed to repair or tighten the torn or stretched ligaments that help hold the joint in place, particularly in young athletes. Common Myths: If you have dislocated your shoulder or another body part, a simple snap will not automatically put the joint back in place, regardless of what TV sitcoms suggest. Instead, ice the injury and seek emergency attention. Follow Us Our Location At KTS Physical Therapy (Kenilworth Therapeutic Services) we want you to heal fast and to your fullest potential! Physical therapy in Severna Park is not the same at every clinic. At KTS Physical Therapy (Kenilworth Therapeutic Services) you are treated in a comfortable and caring environment by an energetic and fun team that makes you feel comfortable and motivated to get the best possible results you can receive in any physical therapy clinic. Our mission at KTS Physical Therapy is to provide … More Physical therapy is a medical science that specializes in helping a body relieve from pain, heal from injury, perform better in work/play/leisure. Pain relief is achieved with all natural means that involves no side-effects or drugs. Procedures such as the following: Pressure-Point Release In this procedure the therapist or clinical assistant searches for muscles that are actively in spasm or causing pain. They then push on the muscle for 1-2 minutes. Initially it will cause soreness but … More | Mid | [
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Q: Is there a way to test if a closure is also a generator? I am working with a PHP class which needs to accept multiple types of iterators and encompass them inside a unified wrapper. One of the types of iterators I need to support (and can!) is an anonymous function containing the yield keyword -- an anonymous generator, essentially. Is there a way in PHP to test whether or not an anonymous function is a generator? The following is a list of methods I have tried (designed to show the outputs, not how I used them): $anon = function() { yield 1; yield 2; }; // build anonymous generator gettype($anon); // "object" $anon instanceof \Traversable; // 0 $anon instanceof \Iterable; // 0 $anon instanceof \IteratorAggregate; // 0 $anon instanceof \Generator; // 0 $anon instanceof \Closure; // 1 -- but doesn't tell me whether or not the closure is actually generator $anon = $anon(); // invoke, then run the same checks gettype($anon); // "object" $anon instanceof \Traversable; // 1 (!!!) $anon instanceof \Iterable; // 0 $anon instanceof \IteratorAggregate; // 0 $anon instanceof \Generator; // 1 (!!!) $anon instanceof \Closure; // 0 As you can see above, I can invoke the anonymous function and then determine whether or not the function is a traversable type, but in order to implement this in a lazy-loading fashion (for example, an anonymous function wrapper around a SQL statement call followed by a yield of each record), I cannot invoke the anonymous function before the foreach iteration. Are there any methods / types in PHP which I am missing that can be used to determine whether or not an anonymous method which has not yet been invoked is a generator? A: $anon = function() { echo 'INVOKED', PHP_EOL; yield 1; yield 2; }; $r = new ReflectionFunction($anon); var_dump($r->isGenerator()); shows bool(true); INVOKED isn't displayed at all, proving that the closure isn't invoked at any time A: For those who are wondering, that anonymous function is not a Generator. It returns Generator as result of its invocation. According to the docs: When a generator function is called for the first time, an object of the internal Generator class is returned. | Low | [
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China has banned imports of poultry from 10 U.S. states, threatening an export market worth about $500 million a year, because of fears it carries a fowl plague, a U.S. embassy official in Beijing said on Wednesday. "China has placed a ban on imports of all poultry and poultry products from 10 states," the official said. Chinese authorities had indicated fears the poultry products carried a virus called highly pathogenic avian influenza (HPAI), he said. The states affected are Arkansas, Florida, Maryland, Utah Minnesota, New Jersey, New York, North Carolina, Texas and Wisconsin. The U.S. embassy official, speaking on condition of anonymity, said there seemed to be some confusion on the part of Chinese quarantine officials over the difference between HPAI and avian influenza (AI). "HPAI has not been found in the U.S. since 1984 and we believe there has been some confusion about the type of AI virus found in the United States and noted by China," he said. A U.S. quarantine official based in China told Reuters last week the virus could not be transmitted to people who ate the meat of infected birds. China is the second biggest market in the world, after Russia, for U.S. poultry products and is its only market for chicken feet. U.S. poultry exports to China in 1995 totalled 330,000 tonnes transshipped through Hong Kong alone, worth US$445 million, according to the U.S. Poultry and Egg Export Council. Every day 30 23-tonne containers of U.S. chicken feet crossed the border from Hong Kong into China, the council's spokeswoman Sarah Li said. The AI virus could be found worldwide, particularly in wild fowl, the embassy official said, and had not been isolated from commercial poultry flocks in the United States. Another U.S. official told Reuters the AI virus may have been detected in ostriches imported from the United States as breeding stock on Chinese ostrich farms. "Ostrich raising in China has become very popular and a lot of the breeding stock is brought in from the U.S.," the marketing official said on condition of anonymity. "We heard that some of the ostrich breeding stock had been found to have AI," the official said. News of the ban surfaced last week and was confirmed by Chinese quarantine officials to the U.S. embassy on Friday. Officials of China's Administration of Animal and Plant Quarantine (CAPQ) and the U.S. Embassy in Beijing met on Tuesday in an effort to resolve the issue, the embassy official said. "It was a frank, candid and open meeting -- they listened to us and agreed that we should talk more about it, which we will as soon as possible," the official said. "Basically, we said we think there's been a misunderstanding, but they said what if it (the AI virus) mutates? We said it didn't and they rejected that," he said. The rejection threatened U.S. poultry markets in China and had also been extended to poultry and poultry meat imports from the Netherlands for the same reason, he said. Officials of the U.S. Animal and Plant Health Inspection Service would travel from the United States to meet their Chinese counterparts. No date had been fixed. -- Hong Kong newsroom (852) 2843-6470 | Mid | [
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Steven Maynard is in the Department of History at Queen's University, where he teaches the history of sexuality in Canada. On Nov. 28, Prime Minister Justin Trudeau delivered a moving apology to Canada's LGBTQ citizens for the federal government's decades of discrimination against our communities. That was the easy part. The government must now turn those apologetic words into meaningful action. A key component of the government's plan is Bill C-66, the Expungement of Historically Unjust Convictions Act. This legislation would provide a process for people convicted of certain same-sex offences now considered historically unjust to clear their records. Story continues below advertisement This sounds good, but Bill C-66 is too limited and overly vague. In its eagerness to show us the money (the bill is backed up by $4-million over two years), the government has secured agreement with all parties in the House of Commons to speed the bill through Parliament with very little debate and no amendments. As a historian who specializes in the study of the criminalization of sexuality in the Canadian past, I have spent nearly three decades researching in the archival court documents and police records that are at issue in Bill C-66. To point out the bill's many problems and to propose solutions, I asked to appear before the parliamentary committee tasked with studying the bill. However, I was told there would be no time for witnesses or even written briefs. This makes a mockery of MP Randy Boissonnault, special adviser to the Prime Minister on LGBTQ issues, who recently said about the limitations of Bill C-66, "That's why committee stage is an important opportunity to look at any possible amendments." As it turns out, the bill went to committee on Monday and, with no more than 45 minutes of perfunctory questions and answers, it sailed through unanimously with no amendments and is headed back to the House for third and final reading. One can appreciate the desire to get the job done. Those most directly affected by the state's discriminatory practices have waited a long time to have their convictions cleared. All the more reason, then, that there should have been extensive consultation with experts on this history during the drafting of the bill. But this did not happen, and it shows. For example, Bill C-66 allows for the possible expungement of convictions for gross indecency, buggery/anal sex and analogous offences under the Naval Defence Act. Yet these represent only a fraction of the Criminal Code categories used historically to persecute and prosecute same-sex sexual behaviour. Take the laws against bawdy houses. In his apology, the Prime Minister mentioned police raids of gay bathhouses, but the bawdy-house laws used to carry out those raids are not included in Bill C-66. For the hundreds of men charged in police raids of bathhouses across the country from the 1970s on, Bill C-66 will be of no use. The same can be said for other Criminal Code provisions used to criminalize same-sex activity. These include indecent acts (used against gay bars and men picked up in parks and other public places), obscenity (used in well-known cases against gay/lesbian bookstores such as Glad Day in Toronto and Little Sister's in Vancouver) and vagrancy (used historically to arrest transgender people). Because none of these offences are included in Bill C-66, anyone convicted under these laws will not be able to apply to have their records expunged. The bill does include the possibility of adding other offences down the road. But why not take the time to specify and include them now? Why wait for an applicant to discover his or her conviction isn't covered by the legislation and be forced to wait for the undoubtedly long process of adding an offence to the law? There are also serious problems with the process to apply for expungement. The bill requires "documents that provide evidence" that the person with whom the applicant had sex consented to the activity. But the bill is entirely vague about what types of documents are required for a successful application. I suspect the drafters of the legislation imagined that consent will be revealed in historical court records of same-sex convictions. But offences such as gross indecency made all same-sex sexual relations illegal regardless of consent, so why would you expect to find evidence of consent or the lack thereof in the records of cases for which consent was not even a legal issue? Story continues below advertisement In the absence of documentation, the bill requires the applicant to make a sworn statement that affirms the sexual encounter was consensual. How will government bureaucrats adjudicate what are often inconclusive historical records or verify sworn statements? On this, the bill is again entirely vague, other than to say officials may conduct a review. History may provide a lesson here. When gross-indecency legislation, first introduced into Canadian law in 1890 and codified in 1892, was debated in the House of Commons, some MPs were concerned about the vague definition of what constituted an act of gross indecency. More than 125 years later, Bill C-66, designed to remedy historically unjust convictions like gross indecency, is on course to reproduce in a different context its own vagueness, in addition to its overly narrow definition of expungeable offences. If Bill C-66 is to be a meaningful part of the apology process, then it requires much more careful consideration. Its inadequacies could have been addressed through the customary committee process of public consultation and parliamentary debate, if these weren't being disregarded for reasons of political optics and expediency. | Mid | [
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Wednesday, December 7, 2011 Interesting take on April 4 'Dear Colleague' letter in Daily Tar Heel Will Doran in The Daily Tar Heel chimes in with concerns about the Department of Education's lowering of the standard of proof for sex offenses. Mr. Doran generally praises the April 4 letter -- which has been widely criticized by persons concerned about the rights of the presumptively innocent -- even the part about accusers having the right of appeal (despite its serious double jeopardy implications for the accused). In any event, it's the standard of proof that gives Mr. Doran concern. He notes that "UNC previously required proof 'beyond a reasonable doubt,' a much stricter burden of proof and the one used in criminal trials." Now, all that the school needs is "a 51 percent likelihood of guilt. No hard evidence, no worries." He correctly notes that the reduced standard means "that innocent students could be wrongly convicted, as sexual assault cases are often very complicated and hazy because emotions run high — and substances are often involved." Mr. Doran attempts to maintain some balance, but he overshoots his mark when he writes the following: "The reasonable doubt standard discourages reporting because many victims think they won’t win and don’t want to relive their pain only to lose the case." There is a logic to Mr. Doran's assertion, but I am aware of no evidence for it, and I follow this area very closely. In fact, last year, the head of RAINN testified before Congress about underreporting, and he noted that "fear of not being believed" is no longer among the prominent reasons for underreporting. See entry re: Scott Berkowitz, here. Beyond that, the fact is, we've been served up one rape "reform" after the next for the past three decades, many of them very significant, with the goal of undercutting underreporting. None of them, we are told, have worked. (Yet we keep funding the same crowd that ineffectively attacks the rape "crisis." Hmm. Why is that?) Why, on earth, do they think this one will work? We've written about the underreporting canard many times and won't repeat ourselves here. It is unfortunate that Mr. Doran seems to accept at face value the unsupported assertion of Morgan Abbott, the Honor Court’s vice chairwoman, who said she supports the change "because it will encourage more students to seek help." Mr. Doran posits an interesting theory when he writes: "If the burden of proof for criminal courts remains the same while the burden of proof for on-campus hearings is reduced, it stands to reason that many victims will turn to the Honor Court rather than police." This means "that abusers could get away with their horrific acts with a mere slap on the wrist. Yes, they might have to miss a year or more at UNC. But they can always enroll somewhere else, get a job, travel or do any number of things that don’t involve going to jail." Again, Mr. Doran overstates his case when he calls the punishment meted out by college disciplinary boards "a slap on the wrist." Expulsion, one of the punishments available to such boards, is often a life-altering event. In addition, it isn't as easy to "enroll somewhere else" as Mr. Doran seems to think. The grave concerns expressed by many people about the April 4 letter are premised on the fact that the punishments meted out can be harsh, and life-altering. That aside, Mr. Doran's point that young women likely will choose to punish the accused in a college hearing rather than a court hearing seems correct. All in all, a commendable effort by Mr. Doran. Still, there is a sense that in his zeal to appear "balanced," he is far too accepting of matters that should be subjected to the well-honed scalpel of critical analysis. | Mid | [
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Takanashi clan fortified residence is an archaeological site containing the ruins of the Kamakura to early Sengoku period fortified residence of the Takanashi clan, local warlords in northern Shinano Province during that period. The site is located in what is now part of the city of Nakano, Nagano in the Chūbu region of Japan. The site was designated a National Historic Site of Japan in 2007. Overview The Takanashi clan was a cadet house of the Minamoto clan which gradually came to dominate northern Shinano Province during the Muromachi period. They were attacked by the Takeda clan from Kai Province and turned to the powerful Uesugi clan of Echigo Province for assistance. The Takanashi were allies of Uesugi Kenshin against Takeda Shingen at the Battle of Kawanakajima. However, with the rise of Oda Nobunaga the Takanashi gradually lost their territory and became retainers of the Uesugi. When Uesugi Kagekatsu was relocated from Echigo Province by Toyotomi Hideyoshi, the Takanashi clan followed him to Aizu and eventually to Yonezawa. The ruins of their former clan residence in Shinano occupies a rectangular site measuring roughly 130 meters east-west by 100 meters north-south, surrounded by a moat and a palisade. The moat had a width of 10 meters and depth of three meters with a V-shaped cross-section. Within this enclosed area, an excavation survey conducted from 1986 to 1994, discovered the foundation pillars for twelve buildings, a well, and Shinto shrine. The remains of a Japanese garden was also discovered. The garden measured eight meters east-west by six meters north-south and contained a pond with three groups of rocks and river stones. It is the only Sengoku period garden to have been discovered in Nagano Prefecture. The site is now a public park and is located approximately 10 meters on foot from Shinshū-Nakano Station See also List of Historic Sites of Japan (Nagano) References External links Nagano city official site Nagano prefecture tourist information {ja}} Category:Kamakura period Category:Sengoku period Category:History of Nagano Prefecture Category:Nakano, Nagano Category:Historic Sites of Japan Category:Archaeological sites in Japan Category:Shinano Province | High | [
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Tom Andrews (American football) Thomas Edward Andrews (born January 11, 1962 in Parma, Ohio) is a former professional American football offensive tackle and center in the National Football League. He played three seasons in the NFL, two for the Chicago Bears (1984–1985) and one for the Seattle Seahawks (1987). He was a member of the 1985 Bears Super Bowl XX winning team. Andrews is currently the senior director of development for Papa John's Pizza. References Category:1962 births Category:Living people Category:People from Parma, Ohio Category:Players of American football from Ohio Category:American football offensive guards Category:Louisville Cardinals football players Category:Chicago Bears players Category:Seattle Seahawks players Category:Sportspeople from Cuyahoga County, Ohio Category:Super Bowl champions Category:National Football League replacement players | Mid | [
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Best jQuery Plugins of the Week [19th April – 26th April] | Low | [
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The invention relates to a piezoelectric actuators and their application within fuel injector valves. Such a piezoelectric actuator may be to actuate a control valve such as a servovalve within fuel injection valve for controlling flow of a medium. These kind of valves can be used for the direct control of an injection needle within an fuel injection valve or indirect control of a needle by means of a control valve. These kind of valves usually comprise a housing having an inlet duct and an outlet duct and, a movable body which can reciprocate in order to control communication between the inlet and the outlet ducts, and drive means for the reciprocating movement of the body. A known valve of this kind includes a piezoelectric actuating member supported in a valve housing, the housing having an inlet duct and an outlet duct and a movable body which can be displaced by the actuating member in order to control in operation a flow of pressurized fluid through a connection between the inlet and outlet ducts, the surfaces of the movable body on which pressurized fluid can produced hydrostatic force being arranged to minimize any resulting hydrostatic force in a direction tending to oppose movement of the actuating member. The possible extension of the piezoelectric element of such a valve and thus the potential stroke of the valve is usually small, for example, of the order to 10 or 20 micrometers. It is therefore essential to minimize the effect of thermal expansion on the valve parts so that the flow through the valve will vary only slightly with changes of ambient temperature. One solution to the problem is to choose a material for the valve housing which material has a similar thermal expansion coefficient to that of the piezoelectric element. An example of such a material is a nickel-iron alloy having a low coefficient of thermal expansion. A possible disadvantage to the use of this material is the high cost of the alloy. U.S. Pat. No. 4,284,263 discloses a control valve having an actuating member supported within and between a closed end and a seat end of a housing, the actuating member has a fixed end connected to the close housing end and a free end connected to a movable valve body. The actuating member includes an elongated piezoelectric element which has a relatively low thermal coefficient of expansion. The housing is made from common, inexpensive materials having moderately higher thermal coefficient of expansion, and the actuating member includes a spacer having a high thermal coefficient of expansion, arranged between the closed housing end and the piezoelectric element. By proper dimensioning of the spacer and housing with respect to the piezoelectric element, temperature compensation may be achieved without the use of exotic materials. However, as shown in FIG. 2 of U.S. Pat. No. 4,284,263, the compensating structure elongates the device significantly. | Mid | [
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Loom Network (LOOM), a blockchain ecosystem for games and social apps, has announced the official public beta for its software development kit (SDK). Loom SDK Public Beta is now LIVE 🍾🎉🥳 That’s right. You’re pumped, we’re pumped. Check out our official announcement, including our Upcoming SDK Roadmap and Token Utility Updates:https://t.co/5EiFdhmbG6 — Loom Network (@loomnetwork) June 12, 2018 In the announcement, the Loom team highlights the number of tools now at the disposal of developers looking to build on their network. These tools, including a number of examples DApps to learn from, are designed to enable a more wide-scale adoption from developers of all skill levels. Also highlighted in the announcement were updates to the project’s 2018 roadmap and clarifications regarding the usage of utility tokens across the network, which has steadily expanded since launching in March. In the coming months, the Loom team anticipates releasing a number of updates to the project’s SDK, network and shared sidechains. Prior to the public beta, Loom has invited select projects to build on its network. Last month, Loom Network announced the addition of the second project built with the platform’s SDK: Neon District, a hybrid card-based futuristic MMORPG. The first game built using the Loom Network SDK is Pixie Shopping Street, a user-generated content platform partnered with Pixie Wardrobe, a game with over 3 million registered users in China and Korea. Loom Network has quietly grown its user base. The project states that over 207,000 developers who have used their course CryptoZombies.io to learn to build Ethereum DApps, and it is fair to assume that a percentage of these developers will look to leverage the newly public SDK. More on Loom Network Loom Network (LOOM) is a platform as a service built on top of the Ethereum blockchain, enabling developers to create and run large-scale decentralized applications (DApps). Loom Network leverages a system of sidechains that allows each DApp to run on its own blockchain, working to reduce the network load facing these applications to further promote speed and scalability. What’s more, developers can use Loom Network’s software development kit (SDK) to code DApps in common programming languages. Through its platform, Loom Network aims to build a scalable infrastructure for the creation of blockchain-based games and social applications. (more) Follow us: Telegram | Twitter | Newsletter | High | [
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Q: How can I set Vivaldi (browser) to use my system window decorators/borders? How can I set Vivaldi to use my system window decorators/borders? With Chrome/Chromium set you do this with a boolean option in the window border’s context menu. I’ve not yet found a similar setting in Vivaldi. A: The current version (Version 1.1) has a checkbox for this under Settings -> Appearance: vivaldi://settings/appearance/ called Use Native Window: | Mid | [
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/** * First we will load all of this project's JavaScript dependencies which * includes Vue and other libraries. It is a great starting point when * building robust, powerful web applications using Vue and Laravel. */ require('./../../bootstrap'); import Vue from 'vue'; import DashboardPlugin from './../../plugins/dashboard-plugin'; import Global from './../../mixins/global'; import Form from './../../plugins/form'; import BulkAction from './../../plugins/bulk-action'; // plugin setup Vue.use(DashboardPlugin); const app = new Vue({ el: '#app', mixins: [ Global ], data: function () { return { form: new Form('payment'), bulk_action: new BulkAction('payments'), } }, }); | Mid | [
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Contact Info x We Can Draft Your Legal Documents and Legal Forms Come to us for paralegal services in Nampa, Meridian, and the surrounding Canyon County If you need a legal form, you probably know of the two primary options. You can pay a small fee to a legal form website and hope that what they send you is accurate. Or you can pay a costly fee for a lawyer to give you one. We offer in person paralegal services in Nampa, Idaho. We provide clients with legal forms for: Leases Divorce proceedings Wills and trusts Custody agreements Adoption With us, you can get a proper legal form without paying a "drafting" fee to an attorney. Learn more about our paralegal services by calling (208) 461-4115 today. Serving Boise, Meridian, Nampa and Caldwell, ID Get professional legal document preparation services One of the reasons many people hire an attorney instead of using an online document bank is to get help filling out legal forms. We offer legal documentation preparation services. We'll give you a questionnaire and use your answers to complete the form for you. You don't need to sit down with an attorney to get legal forms services in the Nampa and Meridian, ID area. Call us now to set up your appointment. | Mid | [
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DALSTON DRESS The Dalston Dress is a beautiful blend of modal and polyester; featuring a gentle give. This fabrication is soft and drapey to the eye. The dress features a modest cut out on the shoulder, a fitted waist and a soft cowl neck. The self-tie is designed to bring in the waist for easy wearing. A flattering and comfortable staple piece. | Mid | [
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Noreen Keating, 72, was CEO and president of Lighthouse of Oakland County for many years. Motivating others, she said, lets them 'do the most incredible things.' / Jarrad Henderson/Detroit Free Press Detroit Free Press Staff Writer Related Links Noreen Keating, who created the first soup kitchen in Pontiac and the first transitional housing in Oakland County, has spent more than three decades raising millions of dollars for causes and bettering the lives of those in need. But the retired CEO and president of Lighthouse of Oakland County attributes her success to others — volunteers like those who turned an abandoned Pontiac building into transitional housing and those who’ve reached into their pockets to donate. “That whole thing of people coming together, if you give them a job to do and they can get it done, it just motivates people, and they do the most incredible things,” said Keating of Auburn Hills. Keating, 72, is a recipient of this year’s Eleanor Josaitis Unsung Hero Award, sponsored by the Free Press and the Metropolitan Affairs Coalition. Those who know her say Keating’s talents allow nonprofits to expand services, reach out to more beneficiaries and establish cooperative programming between agencies. “She has a legacy of being able to cross the missions of multiple agencies and government agencies to get out of their comfort zones to collaborate their sum parts,” said Daniel Stencil, executive officer of the Oakland County Parks and Recreation Commission, who has known Keating for years. Stencil recalled a comment made by one of his staff members about Keating: “She’s one of those people, if she hooks her wagon to something, everybody wants to hook their wagon to hers.” Leading Lighthouse Keating spent 20 years leading and growing Lighthouse, which provides services to low-income families in Oakland County. Lighthouse offers emergency services with food and housing; utility and medical assistance; transitional housing for women and their children, including a Montessori preschool; counseling and work-force development, and rehabilitation and building of homes. Keating left in 2005 and formed a consulting service to help nonprofit agencies and for-profit companies. She works with or serves on more than a dozen boards and committees, including Rainbow Connection and CARE House of Oakland County. The University of Detroit Mercy alumna also volunteers as executive director of the Oakland Parks Foundation, a reinvigorated group to raise money for needs such as historic preservation and horticulture, garden and greenhouse education for Oakland County Parks and Recreation. Diane Bert, who has known Keating for about two decades as a volunteer for Lighthouse, nominated Keating for the award. She said the transitional housing project exemplifies Keating’s work. Lighthouse PATH provides transitional housing for women and their children, helping them move from dependency to self-sufficiency. “I think she’s really a visionary. She sees a problem, dreams about solutions and brings together the resources to make it happen,” Bert said. Grateful for help Keating also values diversity and providing equal opportunities to people from different cultural and social backgrounds. Keating said she came from a poor family. Her grandparents were Irish immigrants and faced discrimination. Her family eventually came to Detroit through Canada and prospered through hard work, she said. Keating — a wife, mother and grandmother — said she always remembered the prejudice and discrimination. And she said her success in helping those in need comes through a simple gesture: thanking people for their donation or volunteered time. “I have this saying, ‘I always dance with who brought me to the prom,’ ” she said. “The saying is you need to be faithful to people who helped you. I need to be faithful to the city and the region who did all that for my family. It’s payback.” | High | [
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THE STRAIGHT DOPE: Spike Lee's finest films have stretched beyond the pigeon hole of "black" stories that critics have reduced him to. It's not so much that focusing on one set of subjects marks a weak filmmaker but rather that Lee's willingness to broaden his reach - and his ability to succeed - shows him to be daring. Some stupidly called 25th Hour Lee's "white" movie but in actuality it's one of his most New York movies. He's often created ensemble pieces with real diversity - diversity of character and motivation. The perfect example was always Do The Right Thing, his finest film and the one with the most complex moral code. 25th Hour is like "Son of Do The Right Thing." The moral spread over the course of the six main characters is stunning when compared to the slack characterizations in most films today. Monty Brogan (Ed Norton) is the drug dealer who's luck finally ran out. Frank Slaughtery (Barry Pepper) is the successful financial adviser who sees morality as clear cut as long as it agrees with his own views. Jacob Elinsky (Philip Seymour Hoffman) is a soft, conflicted teacher with eyes for an underage student. Mary D'Annuzio (Anna Paquin) is his flirtatious, confused, contradictory student. Monty's father James (the outstanding Brian Cox) is a former alcoholic with a tremendous amount of anger directed at himself. Only Monty's girlfriend Naturelle Rivera (Rosario Dawson) is somewhat underwritten, although that might only be because she spends much of the film under a bit of suspicion, mysterious. The story concerns the final hours of Monty's freedom, as he prepares to report for a seven year sentence in prison. There's the cinematically unimportant issue of who turned Monty in to the police to solve but more importantly there's the issue of Monty's soul. Lee takes his time allowing Monty to wander the streets of the city or talk to himself in the mirror. The film has a mournful quality, reflected in Norton's subdued performance, Terence Blanchard's dirge-like score and Rodrigo Prieto's dark cinematography. The whole thing feels like a eulogy for a man that knows he is dying. Even when his friends assure him that they'll be there for his release, Monty knows that seven years behind bars is basically the end of his life. Something Lee does that adds layers to the film's moral complexity is to both allow Monty's guilt to be inarguable - no one ever tries to make the point that Monty got a raw deal - while still protesting the extreme nature of New York's Rockefeller drug laws. One scene in particular details for those who may not know how these laws help lock up non-violent offenders for very long prison terms, certainly out of proportion with other more immediately threatening criminals. But all this glumness serves a point. 25th Hour, after all, is the first serious narrative film made by a major filmmaker to directly address the terrorist attacks of September 11th. This offers a thematic comparison to Monty's dilemma while also adding the kind of contradictory complexity to the film that Lee often revels in. After all, Monty can lament his lack of a future but on some level he knows he deserves it, unlike victims of terrorism. Still, the sense of mourning that Monty feels is analogous to the feeling of living in New York post-attacks. His walks through the street feel similar to the wandering urge many New Yorkers experienced in late 2001. His "F-U" monolog (probably the scene most commented on) brims with the contradictory emotions that all New Yorkers feel. He's also filled with self-doubt and anger, as are many of the other characters. These are wounded people and while they hide behind various masks (cool insider, sarcastic funny guy, sexy seductress) they still feel real and real messed-up. 25th Hour is one of Lee's rare films made from someone else's script, in this case David Benioff's reworking of his own novel. It's easy to see how the director was attracted the material. It has the loose street vibe that his own work often achieves but it also maintains an allegorical quality: It's unreal reality, where the natural dialog and realistic characters do say something beyond their surroundings. Coupled with the plethora of fine performances and thoughtful subject matter, this is Lee's finest work in years. Other than Do The Right Thing Lee's best work operates on a broader pallette: The epic Malcom X or the gritty street opera Clockers. Lately his work has contained interesting elements, like He Got Game, Summer of Sam and Bamboozled, films filled with interesting ideas and intriguing set-pieces that ultimately didn't quite gel or had ugly sides that held them back. Perhaps it was the rejuvenating quality of Benioff's script, a shot of fresh blood, that inspired him to pull back some of the excesses and concentrate on character, mood and place. When they first came out I saw Gangs of New York and 25th Hour as bookends: Portraits of the city leading up to and following 9/11. I think 25th Hour, which has been sadly underappreciated (as have it's provocative score, strong cast and sharp script) still holds up to that position. It's an ode to a city in pain and to people feeling loss. It doesn't weigh down with self-pity but it does manage to explore it and for that balance Lee shows that he's truly a grown-up filmmaker. VIDEO: The anamorphic picture is of a very high quality, handling Lee and Prieto's sophisticated imagery well. The film switches from extreme darkness to blue-tinted club scenes to warm natural light constantly and the transfer handles it all with ease. There are scenes with some extra visible grain - built in to the cinematography - and there are moments with a touch of edge enhancement visible. But for a challenging transfer this one was handled with skill. AUDIO: The Dolby Digital 5.1 score is quite effective. While the film is heavy on the dialog, music does play a key role and the entire spectrum is well-used here. The surrounds are used nicely for Blanchard's textured and challenging score. Lee's films sometimes allow music to overwhelm important scenes but this is one instance where the score fits perfectly while still making a statement of its own. Another big bonus is a program called "The Evolution of an American Filmmaker" which contains interviews with a number of Lee's past collaborators, including Denzel Washington, Ossie Davis, Halle Berry and Martin Scorsese (who produced Clockers). It's a fine biography that leads up to 25th Hour and includes footage from Lee's notorious "tube socks" teaser trailer for his debut film She's Gotta Have It. Another interesting feature is a collection of deleted scenes. Some, like Anna Paquin recreating a Shakespearean death scene could easily have made the cut while others, like a showy montage of every character describing "sway" (what others might call "juice"), are better left out. Lee has shown here an ability to see when something isn't working and remove it. A montage of footage of the Ground Zero recovery effort (some of which appears in the film) is also included, accompanied by Blanchard's score. This is a powerful sequence and makes for a fine short film itself. FINAL THOUGHTS:25th Hour is a mature film that allows for the complexities and idiosyncracies of life. The characters don't have it all figured out and they make lots of mistakes. Their mistakes, however, have consequences and that's where the film finds its real gravity. Unfairly ignored by audiences, this is serious, challenging filmmaking and this fine DVD should allow it a second life. | High | [
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Balanced occlusion or articulation is one of the most discussed topic in complete dentures. However, it is still an unsolved issue that when to give and when not to give balanced occlusion or articulation and also whether to give or not to give balanced occlusion in complete dentures. Due to the fact that a higher importance is given to occlusal aspects of the the complete dentures, the polished surface of the complete dentures is totally neglected. Here is an attempt made to discuss some aspects of denture surface contouring to make balanced denture. Various aspects of polished surface of complete denture contours as well as textures are discussed and critically evaluated in this paper. | High | [
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Category:Teachings In this Category will be offered various teachings of Lamas/Teachers/Masters from differing Schools or Traditions. It will include general teachings, as well as teachings on Sutras, Treatises, Tantras and Shastras. In this Category these should be viewed (if possible...) as Teachings of Dharma and not necessarily particular to any one or separate Sects, Schools, or Traditions. See Rime' (NOTE: If the Teaching you may want to offer can not be rendered in a form which may be universally applicable to all Traditions, then you may like to consider offering it in the Category of Tradition to which it applies.) | High | [
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How McLaren and Williams dropped down the order as the pendulum swung at Sepang After impressing in Melbourne, McLaren and Williams were peripheral in Malaysia. Sky F1 expert Mark Hughes explains why that was - and why things could change again behind dominant Mercedes in Bahrain By Mark Hughes Last Updated: 28/04/15 12:17pm The competitive picture changed significantly between Melbourne and Sepang. The two constants were Mercedes domination and a stronger than initially expected challenge from Red Bull. But falling off the board were McLaren and Williams, each of which had vied with Red Bull as best of the rest after Mercedes in Australia but were nowhere near the pace in Malaysia. What had changed? The respective demands of each track layout and how they impacted upon the traits of each car. Essentially the Albert Park track more greatly rewarded the horsepower and fuel efficiency of the Mercedes engine, whereas Sepang placed greater emphasis on aerodynamic performance. Both qualities are always important of course but their relative importance varies track to track. The Mercedes W05 excels in both areas (to find out why, check out Sky F1's coverage this weekend from Bahrain), the Red Bull RB10 is aerodynamically superb but currently limited by its Renault engine. And the evidence suggests that both the Williams FW36 and McLaren MP4-29 currently lag aerodynamically. The middle sector of the Sepang track mainly comprises fast, long-duration turns that punish any relative lack of downforce hard. If we look to the best times set through there in Sunday's race - taking the fastest time as 100% and relating the deficit of the others by percentage - we get the following picture: There are a few caveats to those numbers. Force India, for example, had Nico Hulkenberg on a two-stop strategy so was on very old tyres when his fuel load was light, so we therefore never saw that car with the optimum combination of low weight and high grip. Fernando Alonso's numbers may be flattered in that he was on new options rather than new primes when his fuel load was lowest, as was Daniel Ricciardo. If we take Sebastian Vettel's best rather than Ricciardo's - to give a like-for-like comparison with the Mercs - the Red Bull number increases to 100.83. But that's still puts the RB10 as a clear second-quickest. Williams' numbers may be unrepresentative in that Massa and Bottas were invariably stuck behind Button's McLaren - but their drivers still reckoned the FW36's main weak point around Sepang was its high-speed grip. "We just don't have enough rear downforce," said Massa of a trait that will hurt the car a lot more here than in Australia. "Each time the circuit grip comes down, we fall back," he pointed out, "and that's a sign of lack of downforce." "We are clearly lacking in downforce, particularly in the high-speed sections," conceded McLaren's Eric Boullier after the race. "We were focussed on reliability for these early races and so our development evolution is at a different phase to those of other teams. We actually gained aero performance here compared to Australia with our new nose. But because of the different circuit demands that still wasn't enough to prevent us falling back. We'd have fallen back further without the new nose. McLaren's new-look nose made its debut in Malaysia "We have more performance going onto the car for Bahrain and more again two races later in Barcelona and we hope these steps will be quite significant. What is encouraging is that the correlation we have seen from factory to track of the new parts was very good. If we have the same correlation with the parts that are coming, then we are going to be moving forward, I'm sure." For Red Bull the problem is not aero but power unit. The repeated low-speed acceleration zones of Bahrain will probably not suit it as well as the extended high speed corners of Malaysia and so we may see Williams and McLaren close back up again there. But Renault is expected to have the first of its hardware limitations fixed for Barcelona (the other follows later in the season) and this in combination with the high aerodynamic demands of the Spanish track suggest the RB10 is going to be even stronger there. As the only car with super-strong power unit and great aero performance, the Mercedes W05 is currently the class of the field. But that's not necessarily a given for the rest of the year. | Low | [
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911 calls -- Published Oct. 5, 2012 There were 85 bookings at the San Joaquin County Jail in the 24 hours ending at 8 a.m. Thursday. At that time, there were 1,382 people held at the jail, which has an official capacity of 1,411. The Record There were 85 bookings at the San Joaquin County Jail in the 24 hours ending at 8 a.m. Thursday. At that time, there were 1,382 people held at the jail, which has an official capacity of 1,411. Found juveniles: Deputies located two 15-year-olds who wandered away from a larger group during a day trip to Dell'Osso Family Farm on Thursday afternoon, officials said. The boy and girl were reported missing about 12:15 p.m. and were found several hours later less than a mile away on Stewart Road near the river, according to authorities. Neither was harmed. Both teens reside at a group home, but officials didn't disclose the name of the organization to protect their identities. Molestation arrest: Daniel Thomas Avelar, 40, of Stockton was arrested on suspicion of child molestation earlier this week, authorities reported. Deputies said they have been investigating a case from three or four years ago, and Avelar, who was arrested Tuesday, was being held on suspicion of lewd and lascivious acts with a juvenile, showing inappropriate materials to a minor and continuous sexual abuse of a child. Robbery: A 77-year-old man answered a knock on his front door in the 4200 block of Boulder Creek Circle about 10 p.m. Wednesday and was held down while robbers ransacked his home, taking numerous items. They were described as men 20 to 30 years old. Shooting: A man wearing a yellow hooded sweatshirt shot a 61-year-old woman as she slept in her bed Thursday morning, police reported. The woman reported the attack in the 3000 block of Anita Way just before 8 a.m., police said. The woman told police she was awakened by a loud bang and realized she was hit. No further details are available. Drug arrest: Ripon police officers arrested Scott Ray Casey, 24, of Hilmar and Victoria Carline White, 36, of Merced on suspicion of possession of a controlled substance and paraphernalia after discovering about 70 grams of crystal methamphetamine, narcotics paraphernalia, marijuana and more than $1,000 in cash in their orange Saturn, officers reported. They had stopped the car for making an illegal U-turn. The California Highway Patrol responded to 13 noninjury accidents and six injury accidents in the 24 hours ending at 8 a.m. Thursday. CHP officers also arrested five people on charges of driving under the influence and recovered one stolen vehicle. The Stockton Fire Department responded to 126 calls for service in the 24 hours ending at 8 a.m. Thursday, including 10 vehicle accidents, 90 medical calls and three structure fires. | Low | [
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Pages Friday, March 21, 2014 Beagle pudgy? A Diet for Dogs -- #HillsPet Metabolic Giveaway Lulu and I get a lot of comments about her figure. It's something I'm pretty proud of. I constantly worry about her weight. A beagle in good shape should have a bit of a slope from the chest up to her tail area. You should be able to JUST make out the ribs when you pet her. You should also have a decent body line when they lay down -- the body should not be so noticeably thicker than the head. Photo courtesy of Dale via Flickr Creative Commons. Beagles, however, have a tendency to get heavy. They don't really have a mechanism that tells them they are no longer hungry. Left to their own devices, a beagle will eat until they burst. Couple that with a craftiness and big begging eyes that melt the heart of most humans, and beagles and food can be a dangerous combination. With Lulu, I monitor her food, limit treats (or replace them with fruits or veggies when possible), keep her away from scraps (no easy task), and make sure she get exercise. (Best viewed on a computer)Looking for help in slimming your beagle down? Keep reading for a chance to win a Hill's Pet Weight Loss and Management Starter Pack. Weight issues are a big problem for both dogs and cats in the United States. According to the Association for Pet Obesity Prevention, in 2012 53 percent of dogs and 55 percent of cats could be classified as overweight at the very least. Plus... your pet may be fat and you don't even realize it! About 22 percent of dog owners and 15 percent of cat owners think their pet is fine, when they aren't. Check out this video. Does your pet look like this? (Best viewed on a computer) This is a special veterinarian-prescribed food to promote weight loss for cats or dogs. Hill's Metabolic is a complete product line, with dry and canned food plus treats.The food is designed to turn up the metabolism and help give cats and dogs more energy. The pets are supposed to feel full and satisfied, but still lose weight. In a study of 314 pet parents who fed their cats and dogs the food at home, 88 percent lost weight in two months. That's not bad. This post is sponsored by Hill’s. I am being compensated for helping spread the word about Hill’s Prescription Diet Metabolic Food, but Life With Beagle only shares information we feel is relevant to our readers. Hill's Pet Nutrition, Inc. is not responsible for the content of this article. Hill's is letting us give away 10 Hill's® Prescription Diet® Metabolic Advanced Weight Solution trial kitsfor dogs or cats. First and foremost -- we must make this clear -- you must, must, MUST get your veterinarian's approval to get this kit. You will have to prove you have their approval. This is a $70 value! 7 comments : I really need this for my dog, Kyoko. She was emaciated when I adopted her - just 30 pounds, when she should have weighed 55-60 pounds. She gained the weight she needed, but still wants to eat like she's starving and got up to 79 pounds. I was able to get her to 75 pounds, but really could use help getting her to a healthier weight. Her health is good otherwise. I volunteer at a local animal shelter called Wanderer's Rest Humane Association in Canastota NY. They had a hoarding case come in with 19 dogs and most of them are extremely over weight. One of them is an older Beagle named Otto he is around 10 yrs old and weighs around 50+ lbs. They could use any help they can get. I have been looking forward to foster him once he is ready. Kelly Vollmer [email protected] | Mid | [
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Ryanodine receptor gene expression thymomas. Ryanodine receptor (RyR) antibodies are present in sera of myasthenics with thymoma, and their titer correlates with morbidity and mortality. We investigated whether skeletal muscle RyR expression in thymic tissues could be the source of immune sensitization to the RyR. Skeletal muscle RyR gene expression was investigated using reverse transcription followed by semiquantitative polymerase chain reaction. Hyperplastic and normal thymuses expressed significant levels of RyR, but RyR gene transcripts was statistically less likely in thymomas than in hyperplastic and normal thymus (P < 0.05). The presence of RyR transcripts in thymomas did not correlate with myasthenic manifestations, thymic pathology, or serum RyR antibodies. We conclude that the skeletal muscle RyR in thymoma is not the inciting antigen for immune sensitization to RyR epitopes in thymoma-associated myasthenia gravis. | Mid | [
0.623188405797101,
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Direct activation of protein phosphatase-2A0 by HIV-1 encoded protein complex NCp7:vpr. The effects of HIV-1 encoded proteins NCp7, vpr and NCp7:vpr complex on the activity of protein phosphatase-2A0 have been tested. We report that NCp7 is an activator of protein phosphatase-2A0 and that vpr activated protein phosphatase-2A0 only slightly. We also report that NCp7 and vpr form a tight complex which becomes a more potent activator of protein phosphatase-2A0 than NCp7 alone. The ability of NCp7 to activate protein phosphatase-2A0 is regulated by vpr. The C-terminal portion of vpr prevents NCp7 from activating protein phosphatase-2A0 while the N-terminal portion of vpr potentiates the effect of NCp7 on the activity of protein phosphatase-2A0. Our findings indicate that vpr may be acting as a targeting subunit which directs NCp7 to activate protein phosphatase-2A0. In view of the fact that protein phosphatase-2A functions as an inhibitor of G0 to M transition of the cell cycle and is involved in other key cellular processes such as the control of RNA transcription, the results presented in this report may explain how HIV-1 causes cell cycle arrest which may lead to CD4+ T cell depletion and also how it disturbs normal cellular processes of its host cell. | Mid | [
0.652956298200514,
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/*------------------------------------------------------------------------------ Copyright (c) CovertJaguar, 2011-2019 http://railcraft.info This code is the property of CovertJaguar and may only be used with explicit written permission unless otherwise specified on the license page at http://railcraft.info/wiki/info:license. -----------------------------------------------------------------------------*/ package mods.railcraft.common.items; import mods.railcraft.common.core.RailcraftConfig; import mods.railcraft.common.core.RailcraftConstants; import mods.railcraft.common.plugins.forge.*; import mods.railcraft.common.util.inventory.InvTools; import mods.railcraft.common.util.misc.Game; import net.minecraft.client.util.ITooltipFlag; import net.minecraft.entity.Entity; import net.minecraft.entity.player.EntityPlayer; import net.minecraft.init.Items; import net.minecraft.inventory.EntityEquipmentSlot; import net.minecraft.item.ItemStack; import net.minecraft.nbt.NBTTagCompound; import net.minecraft.util.ActionResult; import net.minecraft.util.EnumActionResult; import net.minecraft.util.EnumHand; import net.minecraft.world.World; import net.minecraftforge.fml.relauncher.Side; import net.minecraftforge.fml.relauncher.SideOnly; import org.jetbrains.annotations.Nullable; import java.util.List; /** * @author CovertJaguar <http://www.railcraft.info> */ public class ItemGoggles extends ItemRailcraftArmor { private static final String TEXTURE = RailcraftConstants.ARMOR_TEXTURE_FOLDER + "goggles.png"; public ItemGoggles() { super(ItemMaterials.GOGGLES, 0, EntityEquipmentSlot.HEAD); setCreativeTab(CreativePlugin.RAILCRAFT_TAB); } public static GoggleAura getCurrentAura(@Nullable ItemStack goggles) { GoggleAura aura = GoggleAura.NONE; if (goggles != null && goggles.getItem() instanceof ItemGoggles) { NBTTagCompound data = goggles.getTagCompound(); if (data != null) aura = GoggleAura.VALUES[data.getByte("aura")]; } return aura; } public static void incrementAura(@Nullable ItemStack goggles) { if (goggles != null && goggles.getItem() instanceof ItemGoggles) { NBTTagCompound data = goggles.getTagCompound(); if (data == null) { data = new NBTTagCompound(); goggles.setTagCompound(data); } byte aura = data.getByte("aura"); aura++; if (aura >= GoggleAura.VALUES.length) aura = 0; data.setByte("aura", aura); if (getCurrentAura(goggles) == GoggleAura.TRACKING) incrementAura(goggles); } } public static @Nullable ItemStack getGoggles(@Nullable EntityPlayer player) { if (player == null) return null; ItemStack helm = player.getItemStackFromSlot(EntityEquipmentSlot.HEAD); if (!InvTools.isEmpty(helm) && helm.getItem() instanceof ItemGoggles) return helm; return null; } public static boolean isPlayerWearing(EntityPlayer player) { ItemStack helm = player.getItemStackFromSlot(EntityEquipmentSlot.HEAD); return !InvTools.isEmpty(helm) && helm.getItem() instanceof ItemGoggles; } // @Override // public void initializeDefinition() { // BlockHidden.registerBlock(); // if (BlockHidden.getBlock() != null && RailcraftConfig.isTrackingAuraEnabled()) // MinecraftForge.EVENT_BUS.register(new TrailTicker()); // } @Override public void defineRecipes() { CraftingPlugin.addShapedRecipe(new ItemStack(this), true, "GCG", "I I", "LLL", 'C', RailcraftItems.CIRCUIT, ItemCircuit.EnumCircuit.RECEIVER, 'I', "ingotSteel", 'L', Items.LEATHER, 'G', "paneGlassColorless"); } @Override public ActionResult<ItemStack> onItemRightClick(World world, EntityPlayer player, EnumHand hand) { ItemStack stack = player.getHeldItem(hand); if (Game.isHost(world)) { incrementAura(stack); GoggleAura aura = getCurrentAura(stack); ChatPlugin.sendLocalizedHotBarMessageFromServer(player, "gui.railcraft.goggles.mode", "\u00A75" + aura); } return new ActionResult<>(EnumActionResult.SUCCESS, stack); } @Override public String getArmorTexture(ItemStack stack, Entity entity, EntityEquipmentSlot slot, String type) { return TEXTURE; } @Override public boolean getIsRepairable(ItemStack itemToRepair, ItemStack stack) { return OreDictPlugin.isOreType("ingotSteel", stack); } @SideOnly(Side.CLIENT) @Override public void addInformation(ItemStack stack, @Nullable World world, List<String> list, ITooltipFlag adv) { GoggleAura aura = getCurrentAura(stack); String mode = LocalizationPlugin.translate("gui.railcraft.goggles.mode"); String tip = LocalizationPlugin.translate("gui.railcraft.goggles.tips"); list.add(String.format(mode, "\u00A75" + aura)); list.add(tip); } public enum GoggleAura { NONE("gui.railcraft.goggles.aura.none"), TRACKING("gui.railcraft.goggles.aura.tracking"), TUNING("gui.railcraft.goggles.aura.tuning"), SHUNTING("gui.railcraft.goggles.aura.shunting"), SIGNALLING("gui.railcraft.goggles.aura.signalling"), SURVEYING("gui.railcraft.goggles.aura.surveying"), WORLDSPIKE("gui.railcraft.goggles.aura.worldspike"),; public static final GoggleAura[] VALUES = values(); private final String locTag; GoggleAura(String locTag) { this.locTag = locTag; } @Override public String toString() { return LocalizationPlugin.translate(locTag); } } } | Mid | [
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874 A.2d 347 (2005) Victor PINZON, Appellant, v. A & G PROPERTIES, Appellee. No. 02-CV-358. District of Columbia Court of Appeals. Argued April 3, 2003. Decided April 28, 2005. *348 Victor Pinzon, appellant pro se. Stephen O. Hessler for appellee. Before TERRY and FARRELL, Associate Judges, and PRYOR, Senior Judge. TERRY, Associate Judge. This appeal arises from a landlord-tenant dispute. Although the case has a rather protracted history, in the course of which it came before at least five different trial judges, the appeal is taken only from an order releasing to the landlord the *349 money that the tenant previously paid into the court registry under a protective order. We affirm the order releasing the money in the registry to the landlord. I On December 6, 2001, appellee A & G Properties ("A & G") filed in the Superior Court a "Complaint for Possession of Real Estate" against appellant, Victor Pinzon,[1] seeking possession of a basement office in a building on Massachusetts Avenue, N.W., in downtown Washington. The complaint alleged that "[the] commercial lease term [had] expired and occupant failed to vacate at end of term; no notice required in this instance." At a hearing in the Landlord and Tenant Branch before Judge Cheryl Long on December 27, 2001, appellant proffered a lease dated September 1, 2000, which purportedly entitled him[2] to occupy the premises through February 28, 2002. A & G in turn presented a sublease which, it argued, was controlling because it bore a date (December 1, 2000) after the date on the lease proffered by appellant. This sublease, by its terms, expired on November 30, 2001. Judge Long set a trial date for March 1, 2002, the day after the lease proffered by appellant expired.[3] On January 16, 2002, A & G filed a motion for a protective order, asserting that it was "entitled to the traditional protective order ... where the landlord's ability to recover immediate possession is delayed by a tenant request for trial." A & G asked for the order to be retroactive to December 27, 2001, "at the contract rate of $1200 per month." The motion was granted by Judge Steffen Graae, and a protective order was entered on January 18, 2002, requiring appellant to pay $1354 into the court registry by January 31,[4] and $1200 monthly thereafter "until completion of the case or further order of this court." Appellant represented by counsel at the time filed a motion for reconsideration, arguing that the leased premises were a "residential accommodation," and that he therefore had no duty to pay rent because the premises were not in a "habitable condition." He offered a litany of property damage and hazardous conditions allegedly caused by construction work which had been ordered by A & G.[5] The motion for reconsideration was denied. On February 22, 2002, A & G moved for judgment on the pleadings, arguing that there was no defense possible for appellant since the lease that he proffered would expire on February 28, six days later. On *350 March 1 Judge Mary Ellen Abrecht entered a judgment for possession in favor of A & G. On March 12, in an effort to persuade the court to return the money paid into the court registry under the protective order, appellant filed a pro se "Motion to Refund Lease Payments." The crux of his argument was that he had no duty to pay rent while the protective order was in effect because the construction work that was going on during this time rendered the premises "uninhabitable."[6] This motion was scheduled to be heard on March 20, along with a pro se "Application for Stay of Execution of Writ of Restitution," but Judge Zoe Bush granted a continuance until March 26. On the latter date, both motions came before Judge Michael Rankin for a hearing. Appellant asked for another continuance, but that request was denied. Judge Rankin then ordered that the funds in the court registry be released to A & G, and from that order appellant noted this appeal. II The decision to grant or deny a continuance is entrusted to the sound discretion of the trial court, and its ruling will be reversed only for a clear abuse of discretion. E.g., Harris v. Akindulureni, 342 A.2d 684, 686 (D.C.1975). Moreover, in order to win reversal, appellant must demonstrate prejudice resulting from the denial of a continuance. See Hairston v. Gennet, 501 A.2d 1265, 1268 (D.C.1985). We find neither an abuse of discretion nor any identifiable prejudice. Judge Rankin's denial of appellant's motion for a further continuance was not an abuse of discretion. On March 19 A & G filed and served an opposition to appellant's motion for release of funds. Thus, as A & G points out, by the time the March 26 hearing took place, appellant had had one week to prepare with full knowledge of the issues that were going to be raised. Moreover, because the earlier motion for reconsideration filed by appellant's counsel made essentially the same assertions about the construction work and the allegedly hazardous conditions resulting from it, appellant actually had more than six weeks since at least February 8, when Judge Graae denied the motion for reconsideration to prepare for the hearing. Moreover, appellant can show no prejudice resulting from the denial of a continuance. As we shall explain in part III of this opinion, none of appellant's claims of property damage or "environmental and health hazards" were relevant to the proceedings. Thus, even if he had been given more time, it would only have been more time to gather irrelevant evidence. III Appellant argues that the conditions created by A & G's construction work which he says rendered the premises "uninhabitable" should offset the rent paid into the court registry. Such a claim is colloquially known as a Javins defense. See generally Javins v. First National Realty Corp., 138 U.S.App. D.C. 369, 428 F.2d 1071 (1970). *351 Appellant's proffered grounds for a set-off fall into two categories: (1) damage to his personal property and (2) the alleged uninhabitability of the premises due to a lack of heat and hot water and the hazardous conditions attributable to the construction work.[7] A. Damage to personal property With respect to the alleged property damage, the law is clear: "Rule 5(b) of the rules of the Landlord and Tenant Branch[8] does not permit the filing of a counterclaim for damages to the tenant's personalty." Miles Realty Co. v. Garrett, 292 A.2d 152, 153 (D.C.1972) (footnote omitted); accord, e.g., Hines v. John B. Sharkey Co., 449 A.2d 1092, 1093 n. 3 (D.C.1982) ("Claims for personal injury... or for damages to personalty ... may not be raised in the Landlord and Tenant Branch of Superior Court"). Consequently, appellant must bring a separate action in the Civil Division for any alleged damage to his personal property.[9] B. Habitability Because this case involves a commercial (rather than residential) lease, evidence of hazardous conditions created by the construction work was not relevant to the issue of whether appellant should receive a set-off from the money paid into the court registry. The trial court therefore did not abuse its discretion in refusing to allow appellant to present such evidence at the hearing. Protective orders were first suggested in a footnote in the Javins case, 138 U.S.App.D.C. at 381 n. 67, 428 F.2d at 1083 n. 67, and soon thereafter were considered more expansively in Bell v. Tsintolas Realty Co., 139 U.S.App.D.C. 101, 430 F.2d 474 (1970). "In a landlord's action for possession, the court typically enters a protective order requiring the tenant to pay some or all of the rent into the court registry until the suit is resolved." City Wide Learning Center, Inc. v. William C. Smith & Co., 488 A.2d 1310, 1314 (D.C.1985). One of the rationales behind protective orders is that a landlord is "entitled to judicial protection of his fair compensation `for the possession he loses during the period of litigation.'" Dameron v. Capitol House Associates Limited Partnership, 431 A.2d 580, 584 (D.C.1981) (citations omitted). Later, after the landlord-tenant litigation has been resolved, the funds that have been paid into the court registry under the protective order are disbursed by the court. When residential property is involved, this generally occurs after what has come to be known as a McNeal hearing. See McNeal v. Habib, 346 A.2d 508, 514 (D.C.1975).[10] Appellant's claim of entitlement to the funds in the registry is based essentially on his claim that the landlord's construction work on the building made the leased premises "uninhabitable" in other words, on his proffered Javins defense. Such a defense i.e., an assertion, based on alleged housing code violations, that the landlord breached the implied warranty of *352 habitability is not available in this case for at least three reasons. First, we are dealing here with a commercial lease,[11] so that any problems with the property that might be otherwise regarded as housing code violations are irrelevant. See Interstate Restaurants, supra note 5, 309 A.2d at 110 ("The rationale of [Javins] does not, in our view, extend to a commercial lease such as here involved, even assuming that the breaches alleged were of the nature of those fundamentally underlying Javins"). Second despite the unfortunate use of the term "habitable" in the section of the lease upon which appellant bases his claim for a set-off[12] the issue raised by appellant deals not with whether A & G rendered the premises "uninhabitable," but whether it breached the contract by charging rent during the period in which these adverse conditions persisted. Thus appellant's claim is actually one for breach of contract, which must be brought in a separate proceeding in the Civil Division. See Millman Broder & Curtis v. Antonelli, 489 A.2d 481, 484 (D.C.1985) ("where commercial property is involved, the mere fact that a counterclaim is related to the premises does not permit such a matter to be raised under [Landlord and Tenant] Rule 5(b) unless based upon a payment or credit against rent" (citation omitted)).[13] Third, even if appellant could theoretically raise a Javins defense in the commercial context, Rule 5(b) is quite clear that a set-off can be asserted only when the landlord's possessory action is based on non-payment of rent. A & G's action for possession was based not on any failure to pay rent, but on the fact that appellant's lease term had expired. Allowing appellant to litigate such complex issues in the Landlord and Tenant Branch would run counter to the plain language of Rule 5(b) and would frustrate the purpose of the Landlord and Tenant rules, which were "designed to insure an expeditious resolution of landlord-tenant disputes." Campos v. Aguila, 464 A.2d 132, 133 (D.C.1983). IV Finally, appellant argues that A & G was not entitled to possession of the premises. Even if properly preserved for appeal, this argument has no merit. The lease proffered by A & G expired on November 30, 2001, and the lease proffered by appellant expired on February 28, 2002; thus, under either lease, appellant had no right to occupy the premises on or after *353 March 1, 2002 the date on which the judgment of possession was entered. According to D.C.Code § 42-3201 (2001), "When real estate is leased for a certain term ... the landlord shall be entitled to the possession, without [a notice to quit], immediately upon the expiration of the term." Furthermore, even if A & G committed a breach of contract, that breach would not provide appellant any defense in this landlord-tenant action for possession. "In the unique context of a landlord's summary suit for possession, a defense premised upon a failure of the landlord to perform other obligations is inappropriate. Such a failure on the part of the landlord is irrelevant in assessing the propriety of possessory relief, for a tenant is not entitled to withhold rent based on any other asserted breach of contract." Winchester Management Corp. v. Staten, 361 A.2d 187, 192 n. 13 (D.C.1976). V For the foregoing reasons, the order from which this appeal is taken is in all respects Affirmed. NOTES [1] The complaint, as well as the numerous motions that followed, listed the defendant as The Americas Foundation, a non-profit organization of which appellant was president. On July 25, 2002, this court entered an order allowing Mr. Pinzon to proceed on appeal pro se as an individual. [2] The tenant named on this lease was "Victor Pinzon dba The Americas Foundation." [3] Because the record contains no transcript of this hearing and no written findings by Judge Long, it is unclear which lease the judge found to be controlling, if indeed she made such a determination at all. For the purposes of this appeal, however, it makes no difference. [4] This sum included a prorated amount of back rent ($154) for the last five days of December. [5] The motion also stated that "[d]uring numerous visits and inspections the various landlords observed the living quarters in the unit and so long as rent was paid said nothing or objected." Appellant took this approach because, as he acknowledged in his motion, a tenant of commercial property must pay rent regardless of whether the landlord has fulfilled its contractual obligations. See Norris v. Green, 656 A.2d 282, 286 (D.C.1995); Interstate Restaurants, Inc. v. Halsa Corp., 309 A.2d 108, 110 (D.C.1973). [6] Essentially repeating the arguments previously made in the motion for reconsideration (filed by counsel), appellant maintained that the construction work had caused "substantial and extensive damages, business and operational losses, environmental and health hazards ...." Appellant presented an extensive list of hazardous conditions allegedly created by A & G and, in addition, quoted findings by an inspector from the Occupational Safety and Health Administration (OSHA). [7] These hazardous conditions, according to appellant's brief, included exposure to lead paint, asbestos, silica, and construction dust and fumes. [8] See note 13, infra. [9] Appellant acknowledges in his brief that "[t]hese issues will be addressed at another time in another court." [10] A hearing and a court order may not be necessary, however, if the parties can agree between themselves on the disbursement of the money. See McNeal, 346 A.2d at 515 n. 16. [11] Appellant does not renew on appeal his claim that the leased premises were residential. Indeed, he concedes that they were commercial by stating in his brief, "A & G's actions rendered Pinzon's leased space inoperative, uninhabitable; therefore leaving Pinzon unable to operate his normal businesses and or the Foundation's," and that as a result of the landlord's shutting off the water "to the only bathroom" in August 2001, "Pinzon and his ... interns, visitors, business partners and others could not wash their hands or have water in the bathroom." [12] Appellant cites the following language in the lease: "That if said premises become uninhabitable by reason of fire or other casualty not caused by the negligence of the tenant, his servants or agents, the rental herein reserved shall be suspended until said premises shall have been restored to a habitable condition." [13] L & T Rule 5(b) provides in part: (b) Counterclaims. In actions in this branch for recovery of possession of property in which the basis of recovery is nonpayment of rent in arrears, the defendant may assert an equitable defense of recoupment or set-off or a counterclaim for a money judgment based on the payment of rent or on expenditures claimed as credits against rent or for equitable relief related to the premises. No other counterclaims, whether based on personal injury or otherwise, may be filed in this branch. [Emphasis added.] | Low | [
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Drilling at very great sea depths, for example above 2000 meters and notably up to 4000 meters, requires a riser architecture that is different from that of current risers. What is referred to as a riser is an assembly consisting of a central tube, peripheral lines and possibly other equipments. Such a riser allows fluids to be transferred between the water bottom and an installation that is situated at a higher level, i.e. that can be situated substantially at the water surface or underwater, for example just below the surface. In fact, these risers are subjected to various modes of vibration, such as lateral, axial or torsional modes. The present invention concerns more particularly the axial modes of vibration and the term "natural period" defines the axial natural period of the riser, or that of an element of the riser. The invention is particularly well suited for a riser connected by its upper part to a floating installation and whose lower end is free, for example after being disconnected from a blowout preventer or BOP, or from a manifold. When a riser of great length hangs from a drillship and is free at its lower end, the heave of the ship due for example to the wave motion communicates an excitation thereto in the substantially vertical direction. This excitation can induce high stresses in the riser which can damage it significantly and even lead to its breaking. This excitation phenomenon, which can be maintained and increased, becomes particularly critical when the natural period of the riser becomes at least equal to the minimum value of a period range for which the floating installation could be excited significantly by the heave. For example, for a conventional drillship, the period range for which such an excitation has strong repercussions on the riser is above 6 seconds. The risk of excitation of the ship also exists for the 4 to 6-second range, but it is slighter. The natural period of a riser notably depends on the following parameters: its linear density m or mass per unit of length, its axial rigidity ES corresponding to the product of the Young's modulus E by the structural section S, and its length L. The calculation of the natural period of the riser also depends on the geometry and on the dimensioning of the riser, and it is for example described in the article OTC 4317, Offshore Technology Conference, 14th Annual OTC in Houston, Tex., May 3-6 1982. For a water depth of 4000 meters, the "natural" period of a riser of a conventional type used in the petroleum sphere can reach values of the order of 7 seconds, which are within the period range for which a conventional drillship can be significantly excited by the wave motion. The excitation phenomenon can increase for example with the number of peripheral lines whose mass contributes to increasing the natural period of the assembly consisting of the riser and the lines. The prior art thus describes risers comprising notably a central tube and peripheral lines consisting of several elements linked together by slip joints, each one of the elements being immovably fastened to the central tube. The mass of each of the lines thus participates in the mass of the whole riser without participating in its rigidity ES, which leads, in case of great depth, to a value of the natural period of the riser that is great enough for the above-cited problems to be encountered. Furthermore, the increase in the mass of the riser when the water depth increases leads to the emergence of two phenomena which are of little importance and often disregarded for slight and average water depths but which, in the case of great water depths, become much more important and can condition the dimensioning and the characteristics of the risers. The causes and the effects of these phenomena must be carefully studied. The increase in the supertensions due to the inertia of the riser during strong storms can lead to a tension decrease and/or to a compression, notably in the upper part of the riser, and induce therein, in correlation with the other motions (surge, sway) and the direct action of the wave motion, crippling bending stresses. The rise in the natural period of longitudinal or axial vibrations towards values for which the heave amplitude cannot be disregarded can limit considerably, even in relatively calm weather, the operations intended for manoeuvring the riser because of the risks they would present. | Mid | [
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Background ========== Maintenance of variation is a classic paradox in evolution because both selection and drift tend to remove variation from populations \[[@B1]-[@B3]\]. If one form has an advantage (e.g., being more cryptic), it should replace all others. Likewise, random drift alone will eventually result in loss of all but one form when there are no fitness differences. Maintenance of a stable polymorphism requires either recurrent mutation, a balance between dispersal and divergent selection between populations, or some form of balancing selection within populations \[[@B3]\]. For example, predators are expected to form a search image for the most common form if it is easier to search for one cryptic prey type than to simultaneously look for two \[[@B4]-[@B6]\]. If predators switch their search images to whichever prey is most common, the result is frequency-dependent selection against common prey \[[@B4]-[@B7]\]. Empirical tests of this frequency-dependent selection hypothesis are rare, and the link between predator behaviour and maintenance of variation in prey has been difficult to confirm \[[@B4],[@B8]\]. Here, we test whether predatory birds can act as agents of frequency-dependent selection on terrestrial salamanders using a manipulative field experiment. Multiple species of small, forest floor-dwelling salamanders exhibit polymorphism for the presence of a dorsal stripe (Fig. [1](#F1){ref-type="fig"}) and what maintains this polymorphism within populations is a long-standing question \[[@B9]-[@B15]\]. Polymorphism is widespread both geographically and phylogenetically, occurring in many species of *Plethodon*throughout North America in addition to the distantly related *Batrachoseps*of the Pacific coast of North America \[[@B16]\] and *Karsenia*of Asia \[[@B17]\]. Thus, it is unlikely that this polymorphism is merely a transitional stage in the evolution of colour pattern. Presence or absence of a dorsal stripe appears to have a simple genetic basis in *Plethodon cinereus*and is not related to sex \[[@B12],[@B18]\]. {#F1} What polymorphic salamander species seem to have in common is that they are small, slender, and locally abundant. These species often comprise a substantial fraction of the animal biomass in temperate forests and are subject to predation by ground-foraging birds and other predators that search the leaf-litter for small animals \[[@B16]\]. Studies of polymorphic *Plethodon cinereus*have shown differences between the morphs in behaviour \[[@B11],[@B14],[@B15],[@B19]\], physiology \[[@B11],[@B13]\], and geographic variation in relative abundance \[[@B10],[@B20]\]. However, none directly address how these differences might relate to a mechanism maintaining variation and there is no evidence of similar phenotypic correlations in the other polymorphic species. In fact, in *P. ventralis*, the frequency of the striped form is less at higher elevations \[[@B21]\] whereas the frequency of striped *P. cinereus*is greater at higher latitude and cooler microclimates in general \[[@B10],[@B20]\]. Thus, phenotypic correlations between appearance and physiology are not consistent (also see \[[@B13]\]) and this is not surprising given that dorsal colour pattern is unlikely to have a direct function in temperature tolerance or metabolism (*Plethodon*always avoid sunlight). To explain the maintenance of a similar visual polymorphism across many taxa, we propose that selection acts directly on appearance. The most likely function of dorsal colour pattern is crypsis (Fig. [1](#F1){ref-type="fig"}), though this is an untested assumption. Though there has been speculation that the red stripe of *P. cinereus*might be an aposematic signal \[[@B19]\], Brodie and Brodie \[[@B22]\] showed that wild birds prey extensively upon striped *P. cinereus*, and give no sign that the salamanders are unpalatable. Striped *P. cinereus*were taken just as often as *D. ochrophaeus*, which were assumed to be cryptic and palatable \[[@B22]\]. A third, completely red form of *P. cinereus*does appear to be a colour mimic of the toxic Red-spotted Newt eft (*Notophthalmus viridescens*), but our focus is on the more widespread stripe/no-stripe polymorphism. Polymorphism in cryptic prey populations might be maintained in migration-selection balance if alternative colour forms are adapted to different habitats \[[@B23]\], or might be promoted by frequency-dependent predation causing rare form advantage within populations \[[@B4],[@B8]\]. Empirical tests of frequency-dependent foraging on cryptic prey are rare; the best-studied examples involve either colored pellets of dough fed to free-ranging birds \[[@B7],[@B24],[@B25]\]or digital images of moths selected by trained Blue Jays (*Cyanocitta cristata*) \[[@B4],[@B26]-[@B28]\]. These studies demonstrate that birds can generate frequency-dependent selection, that individual Blue Jays learn to focus on abundant prey, and that they readily switch focus in response to changes in prey abundance. Apostatic selection by free-ranging wild birds has been shown for small pastries differing in colour \[[@B7],[@B25],[@B29]\], and presence or absence of a stripe \[[@B30],[@B31]\], and also for real *Cepaea*snail shells differing in banding pattern \[[@B32]\]. However, in other studies, selection changed from negative frequency-dependence (rare form advantage) to positive frequency-dependence (common form advantage) when artificial prey were provided at high densities, showing that rare form advantage is not entirely general and may depend on abundance or aggregation of prey \[[@B25],[@B33]\]. A recent study of Trinidadian guppies implicated frequency-dependent survival in the maintenance of variation in conspicuously colored males \[[@B34]\]. However, it is not clear whether search images are important for predators of conspicuous prey, and other factors might affect polymorphism in sexually-selected traits \[[@B35],[@B36]\]. Thus, whether frequency-dependent foraging can explain the maintenance of polymorphism in realistic prey at realistic densities remains a critical question that might need to be addressed on a case-by-case basis. Here, we show empirically that predatory birds can act as agents of frequency-dependent selection on terrestrial salamanders. To test for frequency-dependent selection by birds, we used standardized models resembling polymorphic *Plethodon*salamanders (Fig. [2](#F2){ref-type="fig"}). A food reward (1/2 peanut) was glued to the underside of each model, and models were set out at random in 10 × 10 m plot at the edge of a woodlot in Knox county, Tennessee (see Methods). We manipulated the relative abundance of striped and unstriped prey and quantified survival by counting the number of models with peanuts still attached at the end of each day. {#F2} Results and Discussion ====================== We observed at least five individual Blue Jays (*Cyanocitta cristata*) foraging on model salamanders. Other birds observed foraging on the ground in the study site included Northern Cardinals (*Cardinalis cardinalis*), American Crows (*Corvus brachyrhynchos*), American Robins (*Turdus migratorius*), and Eastern Towhees (*Pipilio erythrophthalmus*). Only Blue Jays were observed taking peanuts from salamanders. On the first test day, after unstriped models had been more abundant (9:1 for six days), more unstriped than striped model salamanders were attacked (day 7: 16/25 vs. 6/25, Fisher\'s exact *P*= 0.0096). After six days with 5 unstriped and 45 striped models, fewer unstriped models were attacked when tested at equal abundance (day 14: 11/25 vs. 19/25, Fisher\'s exact *P*= 0.0421). Whichever form had been rare (1:9) over the past six days had a significant survival advantage over the common form when presented at equal abundance (Table [1](#T1){ref-type="table"}). ###### \"Survival\" rates of model salamanders. Data are given as number survived/number presented each day. Date^a^ Stripe No Stripe --------- -------- ----------- 6 Jul 1/5 17/45 7 Jul 4/5 21/45 8 Jul 4/5 20/45 9 Jul 4/5 30/45 10 Jul 5/5 35/45 11 Jul 4/5 24/45 12 Jul 19/25 9/25 13 Jul 35/45 3/5 14 Jul 25/45 3/5 15 Jul 16/45 3/5 16 Jul 26/45 4/5 17 Jul 26/45 4/5 18 Jul 25/45 4/5 19 Jul 6/25 14/25 ^a^2008 AD Fig. [3](#F3){ref-type="fig"} shows that striped models had higher relative fitness when at low frequency and lower relative fitness when at high frequency. Multiple logistic regression supported a significant relationship between frequency and survival on non-test days (likelihood ratio *G*^2^= 6.37, df = 1, *P*= 0.0116). There was also a strong effect of \"day\" (*G*^2^= 58.27, df = 12, *P*\< 0.0001), which probably reflects variation in predator activity (predation was lighter on rainy days) and a delay in learning. There was no detectable association between survival and morph (likelihood ratio *G*^2^= 0.225, df = 1, *P*= 0.635). Whichever form was rare had a survival advantage within one or two days after the relative abundances were reversed (Fig. [3](#F3){ref-type="fig"}). Thus, when wild birds were \"trained\" to expect one form to be most common, they preyed disproportionately on that form. This occurred regardless of which form was common. {#F3} Selection by birds can be heterogeneous and these results should be tested at other sites. However, decades of research have consistently found that captive and free-ranging wild birds cause frequency-dependent selection on all manner of food items differing in appearance \[[@B4],[@B6],[@B7],[@B25],[@B26],[@B28]\]. We show that this very general process can operate on the kind of phenotypic polymorphism seen commonly in small salamanders. We have not tested the perceptual and behavioural mechanisms underlying frequency-dependent foraging, therefore we have avoided invoking search image formation as the specific ultimate cause of rare form advantage. Nevertheless, this study joins a growing body of literature showing that birds often switch foraging behaviour in response to the relative abundance of alternative cryptic prey and this can promote the maintenance of colour polymorphism \[[@B4],[@B8]\]. The cognitive processes underlying this phenomenon are important subjects for further research. In addition, a crucial question for the maintenance of polymorphism is to what extent frequency-dependent foraging by visual predators is counteracted by other selective processes, including non-visual predation. Other sources of mortality and other phenotypic differences between morphs might interfere with or enhance the stable coexistence of distinct colour morphs. The conceptual link between promoting polymorphism and promoting coexistence of similar species \[[@B37]\] merits greater attention. Conclusion ========== Rare form advantage owing to frequency-dependent selection by visual predators has been proposed to explain maintenance of polymorphism in many cryptic species \[[@B4]\]. The experiment reported here provides evidence that the key mechanism (frequency-dependent foraging) operates with realistic prey at realistic densities in the wild. The maintenance of colour variation in terrestrial salamanders might be explained by the oldest and most obvious hypothesis -- rare form advantage arises because predators tend to overlook rare prey. Methods ======= Model salamanders were constructed with modelling clay (Sculpey™). One model was sculpted by hand and used to create a flexible mould. This mould was then used to make models of consistent size and body position. Models were either grey-brown or grey-brown with an ochre stripe from the base of the head to the base of the tail (Fig. [2a](#F2){ref-type="fig"}). A food reward was associated with each model salamander by adhering one peanut half to the bottom of the model using edible library paste (40 g corn starch, 1 L water, boiled and cooled). The field site was an open area adjacent to a woodlot in Knox County, TN. Polymorphic *P. ventralis*are known from within 2 km. To avoid spurious loss of models, we used as foraging units 100 black plastic trays (0.185 m^2^) placed in a 10 × 10 array and filled with partially decomposed leaf-litter (natural forest floor substrate). One m of open lawn was left between adjacent trays. Each day, we used a random number generator to assign model salamanders to 50 trays. The ordering of striped and unstriped models was also random; as a result, each tray position had a 50% chance of having a model salamander each day and the probability that the model was striped was the frequency of striped models for that day. The resulting density of 1/2 m^-2^was realistic for small *Plethodon*and *Batrachoseps*salamanders \[[@B16]\]. Models were placed haphazardly within the trays and arranged so that the attached peanut could not be seen without moving the model. This design ensured that foraging birds had the opportunity to learn where to look for salamanders and that all \"surviving\" salamanders would be recovered at the end of each day. In addition, it was important to make sure that each tray was not guaranteed to provide a salamander, so that sometimes giving up and moving to another was the right foraging decision \[[@B27]\]. The experiment was divided into two training periods of six days each and two test days, similar to protocols used with green and brown pastry pellets\[[@B7],[@B25]\]. First, 5 striped and 45 unstriped salamander models were presented each day from 8:00 am until 7:30 pm (it usually took this entire time for the birds to attack roughly half of the salamander models). At the end of the day, the flats were gathered and the number of \"surviving\" salamanders counted (those with the peanut still attached). Six days of training were followed immediately by a test day in which 25 of each morph were presented. After the first test day, another six-day training period was started, this time with frequencies of 45 striped and 5 unstriped salamander models. The second test day (25 of each morph) immediately followed the second training period (Table [1](#T1){ref-type="table"}). We used 2 × 2 contingency tables to test the null hypothesis of equal predation rates for striped and unstriped models on the two test days. For the 12 \"training\" days, we tested for an effect of relative abundance on survival using logistic regression with individual survival as the response variable, day as a random effect, and morph and frequency category as fixed effects. The goodness-of-fit of the model was adequate (likelihood ratio test relative to a saturated model: *G*^2^= 4.03, df = 11, *P*= 0.708) and adding interaction terms did not significantly improve the fit. For all 14 days of the experiment, we estimated fitness (survival value) of striped relative to unstriped models as *w*~*S*~= \[(*S*~*A*~+ 0.5)/(*S*~*B*~+ 0.5)\] ÷ \[(*U*~*A*~+ 0.5)/(*U*~*B*~+ 0.5)\], where *S*~*A*~and *U*~*A*~are the numbers of surviving striped and unstriped models, and *S*~*B*~and *U*~*B*~are the numbers before selection. This estimates the ratio of the survival probability of striped relative to unstriped models \[[@B38]\]. For example, when the two forms have equal fitness, *w*~*S*~= 1.0 and when a striped individual is twice as likely to survive as an unstriped individual, *w*~*S*~= 2.0. Authors\' contributions ======================= BMF Conceived the project, collected and analyzed the data, and drafted the manuscript. KS and RI helped troubleshoot the experimental design, collect and analyze data, and revise the manuscript. All authors read and approved the final manuscript. Acknowledgements ================ We thank R. Fitzpatrick for help with models and fieldwork; and J. Allen, N. Sanders, J. Fordyce, and one anonymous reviewer for comments on the manuscript. This project was supported by the University of Tennessee Pre-collegiate Research Scholars Program. | Mid | [
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[Efficacy of axillary approach brachial plexus blocking by ultrasound-guided four points via one-puncture technique]. To investigate the clinical effects and safety of the technique of axillary approach brachial plexus blocking by ultrasound-guided four points via one-puncture. Eighty patients scheduled for elective operation were randomly divided into 2 equal groups to undergo axillary approach brachial plexus blocking by ultrasound-guided four points via one-puncture technique (Group U) or nerve stimulator-guided brachial plexus blocking (Group N). The main branches of brachial plexus (radial, median, ulnar, and musculocutaneous nerves) were localized by ultrasound-guided or nerve stimulator-guided techniques. In Group U 8 ml of mixed anesthetic solution containing isovolumetric 0.75% ropivacaine and 2% lidocaine was injected into the 4 main branches of brachial plexus, with a total volume of 32 ml. The ultrasonic manifestations of the brachial plexus and its surrounding tissues were observed. The values of diameter and depth of the 4 nerves and the distance of the musculocutaneous nerve to the midpoint of axillary artery were measured. The manipulation time, onset time, maintaining time, efficacy of blocking, and incidence of complication were recorded. The manipulation time of Group U was 5.2 +/- 2.1 min, significantly shorter than that of Group N (14.6 +/- 3.2 min, P = 0.000), The onset times of the median, radial, and ulnar nerves of Group U were 3.3 +/- 1.9 min, 3.0 +/- 1.7 min, and 3.4 +/- 1.9 min respectively, all significantly shorter than those of Group N (4.6 +/- 2.0 min, 7.3 +/- 7.4 min, and 6.4 +/- 6.1 min respectively, P < 0.01 or P < 0.05). The anesthetic success rate of Group U was 100%, significantly higher than that of Group N (77.5%, P = 0.005). The rate of accidental puncture to blood vessel of Group U was 0, significantly lower than that of Group N (40%, P = 0.000). With significantly higher anesthetic success rate, shorter manipulation time and onset time, and lower complication rate, the technique of axillary approach brachial plexus blocking by ultrasound-guided four points via one-puncture is a safe and reliable blocking method in comparison with the nerve stimulator-guided method. | High | [
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Q: Vector of comma separated strings to matrix I have been working on this since an hour and I feel like I ran against a wall: I want to transform a vector of comma separated strings to a matrix. I have a vector like: 'ABC,DFGH,IJ' 'KLMN,OP,DFGH,QR' 'ST,ABC' I want to get a matrix like ABC DFGH IJ KLMN OP QR ST 1 1 1 0 0 0 0 0 1 0 1 1 1 0 1 0 0 0 0 0 1 Sample data: myvec<-c('ABC,DFGH,IJ','KLMN,OP,DFGH,QR','ST,ABC') Base R answers are welcome as well. I might need this trick for some bigger datasets again. A: Another base R solution: > myvec<-c('ABC,DFGH,IJ','KLMN,OP,DFGH,QR','ST,ABC') > mv <- strsplit(myvec,",") > u <- unique(unlist(mv)) > t(sapply(mv, function(x) u %in% x)*1) # output without colnames [,1] [,2] [,3] [,4] [,5] [,6] [,7] [1,] 1 1 1 0 0 0 0 [2,] 0 1 0 1 1 1 0 [3,] 1 0 0 0 0 0 1 > r <- t(sapply(mv, function(x) u %in% x)*1) # adding colnames > colnames(r) <- u > r ABC DFGH IJ KLMN OP QR ST [1,] 1 1 1 0 0 0 0 [2,] 0 1 0 1 1 1 0 [3,] 1 0 0 0 0 0 1 | High | [
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Q: Display results if null or not. SQL I have two tables, ingredient and ingredient_language. I need to display (from SQL) all translations of each ingredient, and in case that I did not have any translations for some language, in the rows have to appear like this, for example: Language | Ingredient ENG Salt GER NULL How can I display it? The structure of the tables are Ingredient{id_ingredient} Ingredient_Language{id_ingredient, id_language, traduction} Thanks. EDIT: SELECT i.id_ingredient, l.id_language, l.trad FROM Ingredient i LEFT OUTER JOIN Ingredient_language l ON l.id_ingredient = i.id_ingredient Okey, the structure are: ·Table 1 (Ingredient) > Columns: Id_ingredient (PK), standard_name ·Table 2 (Language) > Columns: ID_Language (PK), name_language ·Table 3 (Ingredient_Language) > Columns: ID_Ingredient_Language (PK),ID_ingredient (FK), ID_LANGUAGE(FK), description Example of data (Can not do any screen at this moment): ·Table 1: 01, Orange ·Table 2: SP, SPANISH ENG, ENGLISH ·Table 3: 01, 01, SP, Naranja What I need to get? The following example: Header: id_language, id_ingredient, description Row1: SP 01 NARANJA Row2: ENG 01 NULL Thanks for the help. A: You want to start with a cross join, which combines every ingredient with every language: SELECT i.id_ingredient, l.id_language, il.trad FROM Ingredient i CROSS JOIN Language l and add all existing translations to that with LEFT JOIN Ingredient_language il ON il.id_ingredient = i.id_ingredient AND il.id_language = l.id_language if you have a database which does not support CROSS JOIN you can try SELECT i.id_ingredient, l.id_language, il.trad FROM Ingredient i JOIN Language l ON 1=1 LEFT JOIN Ingredient_language il ON il.id_ingredient = i.id_ingredient AND il.id_language = l.id_language | Mid | [
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Q: How can I output month name in a given timezone I would like to have the output of date +"%B, %d %Y" in my local timezone but considering another timezone for the names (month name in this case). In my system the date +"%B" outputs (please note the missing 'y' on 'JanuarY') : Januar I tried: TZ=America/Los_Angeles date +"%B, %d %Y" Output: Januar, 31 2016 From the man page: %B **locale's** full month name (e.g., January) So, I tried to fetch another sequence than %B but, I cannot find one. TZ='America/Los_Angeles' date give the expected output (I ran this command at ~20h in my local timezone) So 31. Jan 11:01:30 PST 2016 Here are some information (if it's relevant): $ date --version` date (GNU coreutils) 8.23 $ date +%Z CET $ uname -a Linux host 4.2.0-25-generic #30-Ubuntu SMP Mon Jan 18 12:31:50 UTC 2016 x86_64 x86_64 x86_64 GNU/Linux A: Month names are not tied to a timezone, but to locale. $ LC_ALL=cs_CZ.utf8 date +%B leden $ LC_ALL=es_ES.utf8 date +%B enero | Mid | [
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The Philadelphia 76ers picked up their first win of the season Friday, only to come right back and drop their next game the following night. On Sunday, the team used its day off to regain clearance for takeoff by visiting the NASA Johnson Space Center in Houston. Rather than focus all of their attention on Monday's matchup against the Houston Rockets, the Sixers instead received a private tour of the facility where human spaceflight training, research and flight control are conducted. Philadelphia point guard Sergio Rodriguez snapped a photo of the main control room, which featured the 76ers logo on a central monitor. NASA astronaut Christina Hammock Koch helped guide the NBA players throughout the complex, and posted a photo of Sixers center Jahlil Okafor attempting to stand inside a space station bedroom. The 6-foot-11 Okafor knows a thing or two about making moves in tight quarters, but this situation presented more of a challenge. It just ain't a 7-footers world...not even in space. NASA welcomes the @Sixers! Ballers make the space Station bedrooms look even smaller! pic.twitter.com/85Hlz1OiaU — Christina H Koch (@Astro_Christina) November 13, 2016 The Sixers might have felt as if they were flying through space, but the reality is that they enter Monday's game last in the Eastern Conference with a 1-8 record. -- Nick Ostiller | Mid | [
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AvWest AvWest is a charter airline and fixed-base operator (FBO) based at Perth Jet Centre in Perth, Australia since 2002. Operations AvWest operates from the Perth Jet Centre, which the company owns at the Perth Airport. The airline operates mainly in Australia and can fly to international locations. Fleet Current fleet: 2 Bombardier Global Express 1 AgustaWestland AW109 2 Bombardier Challenger 604 1 Cessna CE208 1 De Havilland Canada DHC-6-400 Twin Otter 4 Bombardier Global 7000 and 2 Bombardier Global 8000 jets are on order. Former fleet: G-IVSP Gulfstream Corporate Jet - 1 Hawker 800 - 1 References External links AvWest Category:Airlines of Australia | Mid | [
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A diplomatic source in Niger confirmed the ambush, saying that the attackers had come from Mali and had killed and injured several soldiers. Neither source could comment on whether any U.S. troops, who are stationed in the West African country at Agadez, had been killed. WASHINGTON – U.S. investigators on Sunday returned to a village in Niger where four American soldiers were killed in an ambush in October carried out by Islamist militants, the military said. The news came a day after the Washington Post citing villagers reported that Sgt. La David Johnson, one of the four, was found with his arms tied and a gaping wound to the back of the head. The discovery suggested he was captured and executed. The investigative team, comprising U.S. and Nigerien officials, "returned to the village of Tongo Tongo, Niger, on Nov. 12 in order to gain a clearer understanding of the Oct. 4 ambush, the attack site and the surrounding environment, United States Africa Command (AFRICOM) said in a statement. A military investigation has concluded that Army Sgt. La David T. Johnson died in a hail of gunfire, hit as many as 18 times as he took cover in thick brush during an October ambush in Niger. He fought to the end after fleeing militants who had just killed three comrades. The U.S. Africa Command says it has sent a joint team with the Niger military to the village of Tongo Tongo to investigate the Oct. 4 attack by extremists that left four American and four Nigerien soldiers dead. Islamist militants form part of a regional insurgency in the poor, sparsely populated deserts of West Africa's Sahel. Jihadists have stepped up attacks on U.N. peacekeepers, Malian soldiers and civilian targets since being driven back in northern Mali by a French-led military intervention in 2013. | Mid | [
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The Trump White House asked King Abdullah of Jordan to revoke the refugee status of two million Palestinian refugees at a meeting in June, according to Palestinian officials. The revelations came as President Trump’s son-in-law, and senior advisor, Jared Kushner, called for “an honest and sincere effort to disrupt UNRWA”, in emails obtained by Foreign Policy. According to Palestinian officials who spoke to Foreign Policy, Mr Kushner pressed Jordan at a meeting in June, "to strip its more than 2 million registered Palestinians of their refugee status so that UNRWA would no longer need to operate there." UNRWA is the UN agency established in 1949 to support Palestinian refugees, it currently supports some 5 million people spread across Jordan, Syria, Lebanon, the West Bank and Gaza. The Palestinian leadership have made the right of return for those displaced a major issue in previous rounds of negotiations with Israel, which has flatly denied it as an option. In the same email, Mr Kushner wrote “This [agency] perpetuates a status quo, is corrupt, inefficient and doesn’t help peace”. “Our goal can’t be to keep things stable and as they are. … Sometimes you have to strategically risk breaking things in order to get there.” In other emails, Mr Kushner also made reference to the Trump administration’s January decision to cut UNRWA funding by half, withholding $65 million of its budget. “UNRWA has been threatening us for six months that if they don’t get a check they will close schools. Nothing has happened,” he wrote in one email. __________ Read more Haley: Middle East states not doing enough for Palestinians Palestinians to head UN’s biggest bloc of developing nations Donald Trump meets Jordan's King Abdullah and Queen Rania - in pictures __________ The emails were leaked as it was revealed by AP that Mr Kushner and other senior officials had begun recruiting a team ahead of a roll out of their widely speculated-over Middle East peace plan. The National Security Council last week began approaching other agencies seeking volunteers to join the team, which will work for Jared Kushner and Jason Greenblatt, another senior advisor to President Trump, according to the officials. The team, which is being set up to organize the peace plan's public presentation and any negotiations that may ensue, will comprise three units: one concentrating on its political and security details, one on its significant economic focus and one on strategic communications, the officials said. According to Palestinian officials, the US asked Jordan's King Abdullah to revoke the refugee status of two million Palestinian refugees at a meeting in June. Susan Walsh / AP Photo The creation of a White House team is the first evidence in months that a plan is advancing. Although Trump officials have long promised the most comprehensive package ever put forward toward resolving the conflict, the emerging plan has not been described with even a small amount of detail by Mr Kushner, Mr Greenblatt or any other official. Timing on the release of the plan remains undecided. The State Department, Pentagon, intelligence agencies and Congress have been asked to detail personnel to the team for six months to a year, according to the officials, who were not authorized to publicly discuss the matter and spoke on condition of anonymity. | Mid | [
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Maize farmers warned to brace for virus war An agriculture officer inpsects maize crop damaged by the MLN disease. Scientists have urged farmers to brace for a five-year battle with the viral disease that has significantly cut maize production. PHOTO | FILE | NATION MEDIA GROUP Scientists have urged farmers to brace for a five-year battle with a viral disease that has significantly cut maize production and caused Sh4.7 billion losses in the last crop year. Stephen Mugo, a scientist with International Maize and Wheat Improvement Centre, says it will take five years for seed breeders to come up with a variety that can withstand the maize lethal necrosis disease. “We are working with a timeframe of five years to come up with tolerant seeds to bring to an end the spread of this disease,” said Mr Mugo. In the meantime, farmers will have to adopt good farming practices that include crop rotation to help break the cycle of the virus whose rate of infection is high in maize plantations. The virus was first reported in Kenya in 2011 and its devastating effects on the crop have been increasing every year. Last year alone, it affected 10 per cent of the total grain production. In 2013 the disease affected more 26,000 hectares of maize valued at Sh2 billion in what the government has termed as having a negative impact on food security. Also Read Mr Mugo was speaking on the sidelines of an international conference on maze organised by the Alliance for Green Revolution (AGRA) and the Bill and Melinda Gates Foundation to specifically find solutions to MLN. The AGRA President Agnes Kalibata said that the effects of the MLN can no longer be ignored as it has caused massive losses to both farmers and the seed manufactures. “Maize is both a food and cash crop and the effects of MLN also affects food consumers since farmers have no maize crop to release to the market. This therefore calls for urgent need to find a sustainable and widely applicable solution.” Agriculture Principal Secretary Sicily Kariuki noted that there was a significant drop in maize yields since the disease was reported and that the shortfall has a serious ramifications on the national Strategic Grain Reserve. Kenya Agricultural Research and Livestock Organisation in conjunction with the CIMMYT have established MLN screening facility at a cost of $4.5 million, to try and come up with tolerant seeds. The disease has so far spread to other regional countries of Uganda and Tanzania, posing a serious food security challenge given the fact Kenya relies on these states to bridge the annual deficit on maize. | High | [
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IN THE MATTER OF THE REINSTATEMENT OF HOLLAWAY
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Print Only IN THE MATTER OF THE REINSTATEMENT OF HOLLAWAY2020 OK 8Case Number: SCBD-6811Decided: 01/28/2020THE SUPREME COURT OF THE STATE OF OKLAHOMA
Cite as: 2020 OK 8, __ P.3d __ NOTICE: THIS OPINION HAS NOT BEEN RELEASED FOR PUBLICATION. UNTIL RELEASED, IT IS SUBJECT TO REVISION OR WITHDRAWAL. IN THE MATTER OF THE REINSTATEMENT OF: BLAIR STEVEN HOLLAWAY TO MEMBERSHIP IN THE OKLAHOMA BAR ASSOCIATION AND TO THE ROLLOF ATTORNEYS ORIGINAL PROCEEDING FOR RULE 11 BAR REINSTATEMENT ¶0 Petitioner, Blair Steven Hollaway, filed a petition for reinstatement to membership in the Oklahoma Bar Association. By unanimous vote, the Trial Panel recommended that Petitioner should be reinstated. The Oklahoma Bar Association recommends that the findings of the Trial Panel be adopted. Upon de novo review, we determine that reinstatement should be granted and impose costs of $95.11 within thirty (30) days from the date this opinion becomes final. PETITION FOR REINSTATEMENT GRANTED; PETITIONER ORDERED TO PAY COSTS OF $95.11. Blair Steven Hollaway, Moore, Oklahoma, Petitioner/Pro Se, Katherine M. Ogden, Assistant General Counsel, Oklahoma Bar Association, Oklahoma City, Oklahoma, for Respondent. OPINION EDMONDSON, J.: ¶1 Petitioner, Blair Steven Hollaway, filed his Petition for Reinstatement on June 14, 2019 requesting he be readmitted as a member of the Oklahoma Bar Association (OBA) pursuant to Rule 11, Rules Governing Disciplinary Proceedings, 5 O.S. 2011, Ch. 1, App. 1-A (RGDP). Petitioner graduated from the Oklahoma City University School of Law in 2010. He was admitted to the OBA and his name was entered on the roll of attorneys on July 13, 2010. Petitioner resided in Oklahoma until June 2011 but he did not practice law. ¶2 In June, 2011, Petitioner moved to Atlanta, Georgia where he accepted a job as general counsel with a company located in that city. Petitioner's position did not require him to appear in court or to be a member of the Georgia Bar Association. He worked with this company until 2013. Next, he accepted a position with a different company in Georgia as an account executive where he worked from 2013 until January, 2019. Petitioner returned to Oklahoma in February, 2019. ¶3 In 2014, Petitioner's license was suspended for failure to pay his OBA membership dues. In 2015, Petitioner was stricken from the roll of attorneys of the OBA for non-payment of membership dues. ¶4 On September 4 and October 4, 2019, a hearing on the Petition for Reinstatement was held before the Trial Panel of the Professional Responsibility Tribunal (PRT). The OBA did not contest the Petition for Reinstatement but noted that because Petitioner was suspended for five years the PRT was required to make a finding as to whether Petitioner would have to take the bar exam, whether Petitioner engaged in the unauthorized practice of law, and whether Petitioner met the standards for good moral character. ¶5 Petitioner testified at the hearing, and he also presented five different witnesses to testify as to his competency as an attorney, his moral character, and to determine if he had engaged in the unauthorized practice of law. The OBA presented only one witness, the OBA investigator. ¶6 The PRT found by clear and convincing evidence that the Petitioner possesses the competency and learning in the law required for admission to practice law in the State of Oklahoma. Further, that Petitioner has shown that notwithstanding his long absence from the practice of law, he has continued to study the law and he has completed significant hours of continuing legal education. Specifically, the PRT determined that Petitioner was informed as to current developments in the law sufficient to maintain his competency. In addition, the PRT found that Petitioner demonstrated by clear and convincing evidence that he possessed stronger proof of qualifications than an applicant seeking admission to the bar for the first time. ¶7 Petitioner testified under oath that he was not engaged in the practice of law at the time of his suspension and therefore, he had no clients to notify. The PRT found this testimony was sufficient proof for Petitioner to overcome the failure to file an Affidavit pursuant to Rule 9.1 of the Rules Governing Disciplinary Proceedings ("RGDP"). In addition, the PRT found that Petitioner demonstrated by clear and convincing evidence that he possesses good moral character sufficient to entitle him to be admitted to the OBA. Finally, the PRT found that Petitioner has shown by clear and convincing evidence that he has not engaged in the unauthorized practice of law nor has he appeared in court as attorney for any party nor has he participated as counsel of record in any litigation since he was suspended in 2014 and then stricken from the roll of attorneys in 2015. By a unanimous vote, the PRT recommended that Petitioner be reinstated to the Oklahoma Bar Association. ¶8 The PRT's report was filed with this Court on November 20, 2019 and this Court issued a briefing schedule on November 21, 2019. Petitioner filed a Waiver of Right to File Brief in Support on December 10, 2019. The OBA filed a Waiver of Answer Brief on December 17, 2019 stating the OBA agrees with the findings submitted by the PRT and recommended the adoption of all findings by the PRT. ¶9 This Court has the non-delegable, constitutional responsibility to regulate both the practice and the ethics, licensure, and discipline of Oklahoma attorneys. In re Reinstatement of Rickey, 2019 OK 36, ¶ 4, 442 P.3d 571, 574. Our review of the record is made de novo. State ex rel. Oklahoma Bar Ass'n v. Hulett, 2008 OK 38, ¶ 4, 183 P.3d 1014, 1016. In a reinstatement proceeding involving no prior imposition of discipline for attorney misconduct, the focus of our inquiry concerns 1) the present moral fitness of the applicant; 2) conduct subsequent to suspension as it relates to moral fitness and professional competence; 3) whether the attorney has engaged in the unauthorized practice of law; and 4) whether the attorney has complied with the rule-mandated requirements for reinstatement. Rickey, 2019 OK 36, ¶ 4, 442 P.3d at 574. ¶10 The PRT's recommendations, although entitled to great weight, are only advisory as the ultimate decision rests with this Court. In re Reinstatement of Pate, 2008 OK 24, ¶ 3, 184 P.3d 528, 530. Rule 11.4, RGDP, provides an applicant seeking reinstatement will be required to present stronger proof of qualifications than one seeking admission for the first time. In addition, Rule 11.5, RGDP provides the following element: (c) Whether or not the applicant possesses the competency and learning in the law required for admission to practice law in the State of Oklahoma, except that any applicant whose membership in the Association has been suspended or terminated for a period of five (5) years or longer, or who has been disbarred, shall be required to take and successfully pass the regular examination given by the Board of Bar Examiners of the Oklahoma Bar Association. Provided, however, the before the applicant shall be required to take and pass the bar examination, he shall have a reasonable opportunity to show by clear and convincing evidence that, notwithstanding his long absence from the practice of law, he has continued to study and thus has kept himself informed as to current developments in the law sufficient to maintain his competency. If the Trial Panel finds that such evidence is insufficent to establish the applicant's competency and learning in the law, it must require the applicant to take and pass the regular bar examination before a finding as to his qualifications shall be made in his favor. We have held this provision creates a rebuttable presumption that one who has been suspended for five years will not possess sufficient competency in the law to be reinstated, absent an extraordinary showing to that effect. In re Reinstatement of Farrant, 2004 OK 77, ¶ 7, 104 P.3d 567, 569. Each application for reinstatement must be considered on its own merits and the evidence presented in each case. In re Reinstatement of Kerr, 2015 OK 9, ¶ 19, 345 P.3d 1118, 1125. ANALYSIS I. Moral Fitness ¶11 Petitioner has never been disciplined by the OBA; the only issue that arose was his suspension for failure to pay dues. Petitioner was living out of state, not practicing law, and was facing financial difficulties when he was unable to pay his OBA dues. Five different witnesses testified at the hearing that overwhelmingly supported a finding that Petitioner is possessed of good moral character. The PRT found Petitioner had shown by clear and convincing evidence that he possessed good moral character sufficient to be readmitted to the OBA. Likewise, the OBA agreed with these findings. After an examination of the record, we agree with this finding. II. Professional Competence Sufficient for Reinstatement ¶12 Rule 11.5, RGDP, requires petitioners for reinstatement to show they possess the competency and learning in the law required for admission. If they have been suspended or terminated for more than five years, there is a rebuttable presumption they will be required to retake the regular bar examination. However, this presumption can be overcome when a petitioner establishes competence and learning in the law. In re Reinstatement of Gill, 2016 OK 61, 376 P.3d 200.1 ¶13 Petitioner presented evidence that during the time he was suspended his work experience required understanding of the law. He participated in a hearing in Georgia within the parameters allowed under Georgia law and presented evidence of his competency in serving in this role. Other witnesses testified about different independent research conducted by Petitioner reflecting diligence and competency in several different areas of the law. Evidence was presented reflecting that Petitioner was in compliance with his MCLE requirements at the time of his suspension. Further evidence was provided that he completed 30 hours of MCLE in 2019, including 2 hours of ethics. The PRT made a finding by clear and convincing evidence that Petitioner possessed the competency and learning in the law required for admission to practice law in the State of Oklahoma and further that even with his absence from the practice of law, he has continued to study and he has completed significant hours of continuing legal education and kept himself informed as to current developments. The PRT did not find that Petitioner was required to take the Oklahoma Bar Examination. We agree with the PRT and find the Petitioner has proven by clear and convincing evidence he possesses the level of competency and learning in the law to be reinstated to membership in the OBA without re-examination. III. Unauthorized practice of Law and Rule 11.1, RGDP ¶14 The OBA investigator testified she had found no evidence in her investigation that Petitioner had engaged in the unauthorized practice of law during the time of his suspension. The investigator checked various databases, reviewed tax information and conducted an independent investigation. There was no evidence presented to indicate that Petitioner engaged in the unauthorized practice of law. Testimony from witnesses indicated that a hypothetical legal research project done by Petitioner was done under the supervision of an attorney and that Petitioner had not engaged in the unauthorized practice of law. ¶15 Rule 11.1, RGDP provides a mechanism for determining whether a petitioner has engaged in the unauthorized practice of law. Pursuant to this rule, the petitioner for reinstatement is required to submit an affidavit from each court clerk of the several counties in which he resided after suspension or termination of the right to practice law, establishing the petitioner has not engaged in the unauthorized practice of law in their respective courts during that period. Petitioner submitted an affidavit from the Oklahoma County Court Clerk attesting that the Petitioner had not appeared before any judge in the county since his suspension. Further, the investigator for the OBA testified that she found no cause for concern during her investigation into whether Petitioner had engaged in the unauthorized practice of law. ¶16 The PRT's report found the Petitioner had proven by clear and convincing evidence that he has not engaged in the unauthorized practice of law nor has he appeared in court as an attorney of record for any party in any litigation. We find no evidence to the contrary. ¶17 An affidavit from the OBA's MCLE Administrator states that Petitioner did not owe any MCLE credits or MCLE fees. If he is reinstated as a member of the OBA, Petitioner will need to obtain 12 hours of CLE, including 1 hour of ethics for the calendar year in which he is reinstated. An Affidavit from the OBA Director of Administration states that Petitioner will owe only his current membership dues of two hundred seventy-five dollars ($275.00) for the year of his reinstatement. The OBA filed an Application to Assess Costs, pursuant to Rule 11.1 (c), RGDP requesting that Petitioner pay costs in the amount of ninety-five dollars and eleven cents ($95.11) for expenses relating to this investigation. This application included an exhibit that reflects Petitioner was directly invoiced and has paid the costs of the transcript of the PRT proceedings. The record reflects there have been no payments expended from the Client's Security Fund on the Petitioner's behalf. CONCLUSION ¶18 We hold that the Petitioner has demonstrated by clear and convincing evidence his eligibility for reinstatement without examination. Within thirty days of the date of this opinion, Petitioner shall pay the costs incurred in this proceeding in the amount of ninety-five dollars and eleven cents ($95.11) as required by Rule 11.1 (c), RGDP. He will also be required to pay the current year's (2020) OBA membership dues prior to reinstatement and following reinstatement shall complete mandatory continuing legal education sometime this year in the same manner as other members of the bar. PETITION FOR REINSTATEMENT IS GRANTED; PETITIONER IS ORDERED TO PAY COSTS ALL JUSTICES CONCUR. FOOTNOTES 1 Petitioner, Gill presented evidence of work experience that required an understanding of the law. In addition, her understanding of the law was pertinent to her extensive community service. Gill also completed continuing legal education courses as well as other evidence reflecting her competency. Also see, In re Reinstatement of Jones, 2006 OK 33, 142 P.3d 380, Petitioner demonstrated competency by working supervised as a volunteer law clerk, taking continuing legal education classes and regularly reading the Oklahoma Bar Journal; In re Reinstatement of Essman, 1987 OK 102, 749 P.2d 103, Petitioner was employed as a landman which required through knowledge of matters affecting title to real property and negotiation of purchasing oil and gas leases as well as taking continuing legal education classes. Citationizer© Summary of Documents Citing This Document Cite Name Level None Found. Citationizer: Table of Authority Cite Name Level Oklahoma Supreme Court Cases CiteNameLevel 1987 OK 102, 749 P.2d 103, Reinstatement of Essman, Matter ofDiscussed 2004 OK 77, 104 P.3d 567, IN THE MATTER OF THE REINSTATEMENT OF FARRANTDiscussed 2006 OK 33, 142 P.3d 380, IN THE MATTER OF THE REINSTATEMENT OF JONESDiscussed 2008 OK 24, 184 P.3d 528, IN THE MATTER OF THE REINSTATEMENT OF PATEDiscussed 2008 OK 38, 183 P.3d 1014, STATE ex rel. OKLAHOMA BAR ASSOCIATION v. HULETTDiscussed 2015 OK 9, 345 P.3d 1118, IN THE MATTER OF THE REINSTATEMENT OF KERRDiscussed 2016 OK 61, 376 P.3d 200, IN THE MATTER OF THE REINSTATEMENT OF GILLDiscussed 2019 OK 36, 442 P.3d 571, IN THE MATTER OF THE REINSTATEMENT OF RICKEYDiscussed at Length oscn
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How to Roast Spaghetti Squash in the Oven How to Roast Spaghetti Squash in the Oven – a step-by-step tutorial so your spaghetti squash turns out perfectly every time! Spaghetti squash is one of those ingredients that has so many possibilities! I have a ton of fun spaghetti squash recipes up my sleeve, but before we did into those I wanted to get the basics out there on how I prefer to cook mine. It really couldn’t be much easier! I also pre-emptively tried to answer a couple of FAQ’s that I get a lot about cooking/storing spaghetti squash. Let me know in the comments if you have any other questions! How to safely cut a spaghetti squash: I know people commonly get frustrated/nervous cutting a big’ole spaghetti squash in half. Here are my tips for making it a little easier: Use a larger knife that is clean and sharpened. Make sure it is not on a slippery surface Place the whole spaghetti squash in the microwave and cook on high for about 2-3 minutes. This will help soften the outside just enough to help you cut it with a little more ease. How to clean spaghetti squash: Cleaning a spaghetti squash is very similar to cleaning out a pumpkin. Once you have sliced it in half lengthwise, simply take a spoon or ice cream scoop and clean out the seeds, etc. until you can scrape the inside clean! How to store spaghetti squash so they don’t get mushy: I have also gotten a couple of questions about the best method for storing spaghetti squash with the issue being that liquid tends to pool in the bottom of any storage container after a day or so. To help with this I would suggest: Placing your spaghetti squash noodles in a strainer (over a plate to catch the liquid) until they cool completely (you could even sprinkle just a bit of salt to help pull out moisture). Place a handful of noodles on a piece of paper towel and then place another piece of paper towel on top – squeeze very gently to try and soak up some of the liquid. Use a fruit-saver container that will separate the spaghetti squash from the bottom of the container, keeping the liquid and squash separate. (Here is an example of one – I am sure there are lots of different varieties out there). Here is the step-by-step: Step 1: Cut squash in half Step 2: Scrap out seeds. Step 3: Flip over and roast on parchment-lined baking sheet. Step 4: Remove from oven and let cool slightly. Step 5: Use fork and gently scrape “noodles” lengthwise across the squash. Step 6: Use immediately in recipe or save in airtight container in fridge. How to Roast Spaghetti Squash in the Oven Description A step-by-step tutorial on how to roast spaghetti squash in the oven so it turns out perfectly every time! Roasted spaghetti squash is the first step for so many recipes – the possibilities are endless! Instructions Place spaghetti squash cut-side down on parchment and roast in oven on middle rack for 1 hour. Optional: rub ghee, olive oil or butter on the inside first and sprinkle with a little salt – I personally don’t do this, but feel free to if you would like! Remove from oven and let cool slightly. Take fork and gently scrap from one end to the other (the long way). Use in your favorite spaghetti squash recipe! Notes If you struggle cutting spaghetti squash in half, place in the microwave whole for 3 minutes on high to help soften the outside first. If you like a more firm spaghetti squash “noodle” simply reduce cooking time by 10-15 minutes. Spaghetti squash can be prepped ahead of time for the week. Store in air-tight container and keep in refrigerator for 3-5 days. To help reduce water pooling in your storage container, place cooked and spaghetti squash noodles in strainer over a plate. You can also use one of these containers like these to help keep the noodles separate from any liquid. Did you make this recipe? Thank you so much for reading & supporting The Wooden Skillet! This post contains affiliate links for products I actually use in my own home and personally recommend. Should you make a purchase using one of these links, The Wooden Skillet will earn a small commission at no extra cost to you, which helps me continue to bring you great original content. Thank you! Hello Friends! I'm Erin - photographer, recipe developer and creative content creator behind The Wooden Skillet! I love sharing healthy, inspiring meals, real food, healthy living and so much more. You will find lots of dairy-free, Whole30, paleo and plant-based recipes, but also the occasional cocktail and indulgence because .... you gotta have balance! To learn more about me Click Here | Mid | [
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Q: JavaScript XHR w/ GitHub API I'm trying to use XHR to access the GitHub HTTP API, and I'm being rather badly defeated by the Same Origin Policy. I'm quite sure that easyXDM is overkill for this, but I don't know what else (if there is anything else) that I can use. Is there some easier way than easyXDM to get from my website to the GitHub API? A: Turns out GitHub API supports JSON-P. from http://developer.github.com/v3/#json-p-callbacks: You can send a callback parameter to any GET call to have the results wrapped in a JSON function. This is typically used when browsers want to embed GitHub content in web pages by getting around cross domain issues. (emphasis mine) | Mid | [
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Differences between cough and Valsalva leak-point pressure in stress incontinent women. The aim of the study was to evaluate the relationship between Valsalva leak-point pressure (VLPP) and cough leak-point pressure (CLPP). Sixty women with stress urinary incontinence were included. One woman was excluded from evaluation because of detrusor instability. At a bladder volume of 200-300 mL (mean, 284; standard deviation, 29) CLPP and VLPP were measured in the sitting position. Intra-abdominal pressure was recorded with a rectal balloon catheter. A standardized pad test and multi-channel urodynamics were performed. VLPP was significantly lower than CLPP (58.9+/-27.6 versus 112.5+/-46.9 cm H(2)O, P<0.0001). Although CLPP was negative in two women only, VLPP was negative in 24 of 59 women (40.1%). If intrinsic sphincter deficiency was defined as a leak-point pressure of 65 cm H(2)O, 16.9% of women fulfilled this criterion using the CLPP compared to 35.6% if the VLPP is used. In conclusion, coughing and Valsalva seem to result in a different reaction of the pelvic floor. | Mid | [
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Lenehan's, Adelino's join failed downtown eateries Jonas Lenehan always dreamed of owning a pub in downtown Lafayette. But later this month, he'll close the doors at Lenehan's Pub at 601 Main St. and walk away from that dream forever. "It's difficult down here," Lenehan said. "Unless there's a festival or some sort of event downtown, there's not a whole lot of foot traffic." Lenehan's will close Feb. 21 after less than two years at its location on the corner of Main and Sixth streets. More alarming is that the restaurant's demise is just the latest in a string of closures of downtown eateries. This week, Adelino's Old World Kitchen closed its doors, following an eviction complaint filed last week. After more than five years of business at 112 N. Third St., the restaurant found itself facing more than $33,000 in unpaid rent and utilities, according to court records. Property owner Witeveen & Kessler LLC. filed a complaint Jan. 27 in Tippecanoe Superior Court 1 to regain possession of the property. In the complaint, attorneys state the restaurant failed to pay rent from December 2014 to January 2015 and has not paid nearly $20,000 in its share of utility costs. A phone number listed for Tracy Rosa, the restaurant's owner, was disconnected as of Wednesday. Adelino's and Rosa have a history of financial trouble, including several small claims cases, according to Tippecanoe County court records. Three cases are unresolved. In 1996, according to court records, Rosa was charged with theft and receiving stolen property — both Class D felonies — that were later converted to Class A misdemeanors. Andrew Gutwein, a Lafayette attorney who has represented Adelino's and Rosa in past financial matters, declined to comment on the situation via a secretary. Lafayette economic development director Dennis Carson was disappointed to learn of the closures. "I never like to hear that a business is closing because I know how much effort these owners put in them," Carson said. "But without knowing exactly why or what particular challenges they have or had, it's difficult to say what could have been done or how we could help." Carson said groups like Greater Lafayette Commerce and Friends of Downtown try to make downtown inviting to potential customers. But it's not always enough. "The restaurant industry is very competitive and consumer tastes are always changing," Carson said. Serendipity owners closed their restaurant at 731 Main St. last year after two years downtown. Ivan Brumbaugh made the same decision last November when he closed his two eateries, Main Street Cheese & Wine and Uncorked, due to a lack of business. Brumbaugh's was one of a handful of downtown restaurants to suffer tax trouble last year — a problem that spilled into the public eye when the state required Uncorked, Bistro 501 and Sunrise Diner to plaster bright orange signs on their doors to alert customers to unpaid taxes. Bistro 501 and Sunrise Diner remain open sans signs. The space occupied by Lenehan's is particularly notorious. In less than a decade, five businesses have opened and died in that location: First was Cajun Connection, opened in 2003 and closed in 2007. Next up, Scagnoli's Cajun & BBQ, opened April 24, 2008, before closing March 2009. In 2011, La Salsa opened; it lasted four months. DT Kirby's opened a family-style off-shoot of its sports bar in the space in October 2011. That restaurant lasted one year. And now Lenehan's, which opened in May 2013. Lenehan named it after his father, who owned O'Lenehan's Pub in Frankfort. The family closed the Frankfort location in order to devote its full attention to Lafayette. Lenehan said business was rough. He had anticipated more foot traffic from Purdue University students but instead found the majority had no interest in crossing the river. "I sat down with a lot of my family probably around September and said if things don't turn around this fall there's a good chance we're probably going to be closing after the first of the year," Lenehan said. Things only compounded recently when the building was sold and Lenehan was unable to come to terms on a new lease with the new owners. The pub's fate was sealed. "It's extremely disappointing," Lenehan said. "But it is what it is. It's disappointing but I'll move on. I've got a family to think about." | Low | [
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-r - 1 Let p(n) = -9*n**2 - 5*n + 3. Let j(l) = -4*l**2 - 3*l + 1. Calculate 5*j(i) - 2*p(i). -2*i**2 - 5*i - 1 Let n be (5 - 2)*(-8)/(-6). Let m(a) = -a**3 + a**2 - a - 1. Suppose -11*w + 7 = -4*w. Let z(d) = 6*d**3 - 4*d**2 + 3*d + 4. What is n*m(f) + w*z(f)? 2*f**3 - f Let w(l) = 6*l**2 + 2*l + 1. Let t(s) = -33*s**2 - 11*s - 2. Calculate -t(p) - 4*w(p). 9*p**2 + 3*p - 2 Let y be (1 + 2)/((-5)/5). Let a(f) = 3*f - 4. Let o(c) = 1. Determine y*o(d) - a(d). -3*d + 1 Let l(s) = -4*s**3 - 6*s**2 + 11*s + 6. Let v(n) = -6*n**3 - 8*n**2 + 16*n + 9. Calculate 7*l(c) - 5*v(c). 2*c**3 - 2*c**2 - 3*c - 3 Let t = -24 - -35. Let p(b) = 17*b**3 - 11*b**2 - 14*b. Let z(s) be the third derivative of s**6/20 - s**5/15 - 5*s**4/24 + 20*s**2. Determine t*z(j) - 4*p(j). -2*j**3 + j Let j(a) be the first derivative of -3/2*a**2 + 4*a - 3. Let d(s) = 6*s - 11. Let i(w) = w. Let b(o) = -d(o) - 2*i(o). Give 4*b(x) - 11*j(x). x Let m(c) = -3. Let v(l) = -93*l + 12. Calculate 4*m(b) + v(b). -93*b Let b(x) = 216. Let g(f) = -21. Let c(y) = b(y) + 10*g(y). Let r(t) = t. Determine c(w) - 2*r(w). -2*w + 6 Let g(d) = -11*d + 4 + 17*d + 2. Let i(w) = 2*w + 2. Determine -3*g(b) + 8*i(b). -2*b - 2 Let t(s) = -40*s**2 - 13*s - 8. Let k(n) = 119*n**2 + 37*n + 23. Calculate -6*k(d) - 17*t(d). -34*d**2 - d - 2 Let v(o) = -4*o - 4 + 2 - 2 + 6. Let w(u) be the second derivative of 5*u**3/6 - 3*u**2/2 + 2*u. Suppose 0 = -8*m - 48 + 16. Determine m*v(k) - 3*w(k). k + 1 Let i(x) = -44*x + 17. Let f(y) = 107*y - 6 + 128*y - 220*y. Give 17*f(o) + 6*i(o). -9*o Let u(x) = -22*x + 5. Let i(d) = -16*d + 3. Calculate -8*i(v) + 5*u(v). 18*v + 1 Let l(d) = 3*d - 3. Let z(i) = 3*i - 4. Suppose 36*m - 84 = 15*m. Let p = 50 - 53. Give m*l(t) + p*z(t). 3*t Let z(c) = -1 + 271*c**2 - c**3 - 273*c**2 + 3. Let f be (-1)/((-2)/(-4)*2). Let k(a) = a**3 + a**2 - 1. What is f*z(l) - 2*k(l)? -l**3 Let s(x) = 19*x - 7. Let t(g) = g - 1. Calculate -s(p) + 6*t(p). -13*p + 1 Let c(k) = -8*k**3 - 9*k**2 - 8*k. Let b(l) = 7*l**3 + 8*l**2 + 7*l. Suppose -6 = 2*w - 4*d, 4*w + 22*d - 28 = 20*d. Give w*c(z) + 6*b(z). 2*z**3 + 3*z**2 + 2*z Let b(f) = f. Suppose 10*q - 6 = 8*q. Let l(v) = -3. Let h(o) = -4. Let z(w) = q*l(w) - 3*h(w). Calculate -2*b(y) - z(y). -2*y - 3 Let b(r) = -3*r**3 + 5*r**2 - 6*r. Let k(g) = -2*g**3 - 3*g**2 - 7*g. Let o(s) = s**3 + s**2 + 3*s. Let z(q) = 2*k(q) + 5*o(q). Give -b(d) - 6*z(d). -3*d**3 + d**2 Let s(j) = 18*j + 2. Let x(d) = -22*d - 2. Let m(w) = 6*s(w) + 5*x(w). Let b(h) = -4*h + 5. Suppose 45 = -0*i - 5*i. Calculate i*m(f) + 4*b(f). 2*f + 2 Let y(k) = -7*k**3 + 3*k - 13. Let u(v) = -14*v**3 + 7*v - 25. Give 3*u(r) - 7*y(r). 7*r**3 + 16 Let i(d) = 10*d + 3. Let x(b) = b + 1. Let u be (-4)/(-7)*(-350)/300*3. What is u*i(g) + 6*x(g)? -14*g Let q(k) = -81*k - 17. Let l(s) = -16*s - 3. What is 11*l(u) - 2*q(u)? -14*u + 1 Let u(l) be the first derivative of l**2 + l - 104. Let c(w) = 2*w + 1. Calculate -6*c(h) + 7*u(h). 2*h + 1 Let d(i) = -15*i**2 + 13. Suppose 12 = 7*p - 9. Let j(b) = -14*b**2 + 14. Let k(r) = p*d(r) - 2*j(r). Let n(a) = -8*a**2 + 5. Give 6*k(g) - 13*n(g). 2*g**2 + 1 Let d(x) = 8*x**2 + 3*x + 5. Let g(u) = u**2 + 1. Suppose 0 = 109*a - 95*a + 14. Determine a*d(m) + 6*g(m). -2*m**2 - 3*m + 1 Let d(j) = 13*j**2 - 33*j + 18. Let i(p) = 7*p**2 - 17*p + 9. Calculate 6*d(r) - 11*i(r). r**2 - 11*r + 9 Let l(h) = 13*h**2 - 31*h + 2. Let i(a) = 2*a**2 - a + 1. What is 4*i(c) - l(c)? -5*c**2 + 27*c + 2 Let h(b) = -6*b**2 - 5*b - 22. Let f(s) = -4*s**2 - 3*s - 15. Give -8*f(l) + 5*h(l). 2*l**2 - l + 10 Let r(o) = -4*o**2 + 7*o - 3. Let f(v) = 2*v**2 - 3*v + 1. Let a(m) = m + 4. Let h(b) = 4*b + 17. Let q be h(-4). Let s be a(q). Calculate s*f(k) + 2*r(k). 2*k**2 - k - 1 Let u be 102/8 + (5 + 1)/24. Let n(m) = -2*m**2 - 11*m + 2. Let f(s) = s**2 + 5*s - 1. Let t(l) = u*f(l) + 6*n(l). Let y(p) = 2. Determine -2*t(i) - 2*y(i). -2*i**2 + 2*i - 2 Let o(v) = 3*v + 73. Let z(n) = 17*n + 365. What is 11*o(c) - 2*z(c)? -c + 73 Let n(h) = -5*h**2 + 4*h - 8. Let u(q) = -7*q**2 + 5*q - 10. Calculate 6*n(b) - 5*u(b). 5*b**2 - b + 2 Let f(v) = v + 1. Let n(r) = -3*r - 3. Let q be -2*1/(-4)*2. Let x = -1873 + 1875. Calculate q*n(z) + x*f(z). -z - 1 Let z(b) = b**3 + 2*b**2 + b + 1. Let a(y) = y**3 - 14*y**2 - 6*y - 6. Let v(l) = -a(l) - 6*z(l). Let s(p) = -14*p**3 + 3*p**2. Determine -3*s(c) + 5*v(c). 7*c**3 + c**2 Let m(h) = -317*h**2 + 15. Let c(a) = -3. Determine -5*c(y) - m(y). 317*y**2 Let g(n) = 2*n**2 + 3*n - 1. Let d(h) be the second derivative of h**4/6 + h**3/3 - h**2/2 - 16*h + 2. Give -4*d(b) + 3*g(b). -2*b**2 + b + 1 Let p(x) = 300*x + 4. Let j(z) = -z + 2. Determine -2*j(c) + p(c). 302*c Let l(w) = -2*w**2 + 5*w. Let r(x) = 2*x**2 - 5*x. Let a(b) = b**3 - 13*b**2 - 29*b - 11. Let h be a(15). Determine h*r(p) + 5*l(p). -2*p**2 + 5*p Let b(p) = -1 + 0 + 0. Let r(d) = -11 - 19 - 2*d + d**2 + 22. Give -5*b(f) + r(f). f**2 - 2*f - 3 Let f(q) be the second derivative of q**4/12 + q**3/6 + 437*q. Let h(z) = -3*z**2 - 7*z. Determine 5*f(i) + h(i). 2*i**2 - 2*i Let i(q) = 2*q**3 - 3*q**2. Suppose -2*f - f = -9. Let t(x) = x**f - 6*x**3 + 4*x**2 + 3*x**3. Let b be ((-4)/20*4)/((-10)/50). What is b*t(u) + 5*i(u)? 2*u**3 + u**2 Let h(l) = 6*l**3 - 5*l**2 - 6*l + 7. Suppose -3*i = i - 20. Let r(g) = 5*g**3 - 4*g**2 - 5*g + 6. Let c = -150 + 146. What is c*h(t) + i*r(t)? t**3 - t + 2 Let i(v) = -2*v**3 + 68*v**2 + 12. Let w(b) = 2*b**3 - 69*b**2 - 10. Determine 5*i(z) + 6*w(z). 2*z**3 - 74*z**2 Let c(r) be the third derivative of 4*r**5/15 + 53*r**2 + r. Let v(t) = -8*t**2. What is -2*c(o) - 5*v(o)? 8*o**2 Let o(f) = -11*f - 10. Let k(v) = 5*v + 5. Let y be (-6)/(13/(273/(-14))). Determine y*k(s) + 4*o(s). s + 5 Let d(c) = -15*c**3 + 30*c**2 + 5*c. Let b(k) = 12*k**3 - 30*k**2 - 4*k. Calculate -4*b(g) - 3*d(g). -3*g**3 + 30*g**2 + g Let q(c) = -6*c + 9. Let s(r) = 10 - 2*r - 4 + 5 - 8. Give 2*q(f) - 7*s(f). 2*f - 3 Let i(l) = -8*l**2 - 5*l - 5. Let s(g) be the second derivative of -17*g**4/12 - 11*g**3/6 - 11*g**2/2 + 6*g - 3. Give -13*i(m) + 6*s(m). 2*m**2 - m - 1 Let x be 105/140 - (-23)/(-4). Let m(g) = 15*g**2. Let d(u) = 8*u**2. Determine x*d(o) + 2*m(o). -10*o**2 Let t(h) = 2*h**3 - 4*h**2 - 2*h + 3. Let s(g) = -8*g**3 + 12*g**2 + 5*g - 11. Let d(m) = m**3 - m**2 + 1. Let a(y) = -4*d(y) - s(y). What is 3*a(x) - 7*t(x)? -2*x**3 + 4*x**2 - x Suppose 0 = -3*b + 2*u - 4, 2*u + 0*u = -5*b - 12. Let m(o) = -8*o**3 - 3*o**2 + 3*o + 3. Let i(s) = 8*s**3 + 2*s**2 - 2*s - 2. Give b*m(j) - 3*i(j). -8*j**3 Let q(j) = 5 - 15 - 1 + 8*j - 18. Let t(l) be the third derivative of l**4/12 - 7*l**3/6 + 274*l**2. Determine -2*q(i) + 9*t(i). 2*i - 5 Let y(t) = 4*t + 40. Let w be y(-11). Let o(n) = 8*n**3 + 4*n**2 + 4*n + 2. Let d(m) = m**3 + m**2 + m + 1. What is w*d(x) + o(x)? 4*x**3 - 2 Let z(t) = -12*t**2 - 10*t - 2. Let g(j) = -10*j**2 - 8*j - 2. Give -5*g(c) + 4*z(c). 2*c**2 + 2 Let q(o) = -3*o**2 - 60*o + 1. Let g(v) = 7*v**2 + 121*v - 2. Determine -2*g(t) - 5*q(t). t**2 + 58*t - 1 Suppose -11 = 2*h + 39. Let r be (4/(-5))/((-5)/h). Let d(u) = u**2 + 2*u + 1 + 5*u - 7*u**2 - 4. Let n(y) = 5*y**2 - 6*y + 2. Calculate r*d(o) - 5*n(o). -o**2 + 2*o + 2 Let w(u) = -6*u**2 - 84*u + 2. Let x(c) = 4*c**2 + 83*c - 1. Calculate -3*w(g) - 4*x(g). 2*g**2 - 80*g - 2 Let x(r) = 2*r**3 + 3 - 6*r**3 - 255*r + 248*r. Let g(u) = -9*u**3 - 15*u + 7. Calculate 3*g(h) - 7*x(h). h**3 + 4*h Let c(s) = -s**2 + s + 1. Let l(w) = 2*w**2 - 47*w - 1. Determine 3*c(z) + l(z). -z**2 - 44*z + 2 Let k(v) = -2*v**2 - 6*v + 1. Let q = -407 + 406. Let p(g) = g - 1. Calculate q*k(h) - 2*p(h). 2*h**2 + 4*h + 1 Let i = 154 + -177. Let o = i + 19. Let g(l) = 6*l**3 - 9*l**2 - 9*l - 9. Let b(v) = -3*v**3 + 4*v**2 + 4*v + 4. Calculate o*g(h) - 9*b(h). 3*h**3 Let f(n) = -7*n**2 - 7*n. Let s(x) = -6*x**2 - 6*x. Suppose 3*z = -3*a - 18, 30 = z - 6*z + 4*a. Give z*s(d) + 5*f(d). d**2 + d Let w(f) = 187*f**3 + 5*f**2. Let z(y) = -21504*y**3 - 576*y**2. Calculate -576*w(n) - 5*z(n). -192*n**3 Let p(m) = -7*m**3 - 4*m**2 + 10*m + 53. Let k(q) = 11*q**3 + 6*q**2 - 16*q - 79. Give -5*k(r) - 8*p(r). r**3 + 2*r**2 - 29 Let n(h) = h**2 + 2*h + 1. Let b(x) = 4*x + 12. Calculate b(g) - 3*n(g). -3*g**2 - 2*g + 9 Let t(z) = -z**2 - z - 1. Let i(h) b | Low | [
0.498924731182795,
29,
29.125
] |
import _ from 'lodash'; import { flow, filter, each } from 'lodash/fp'; /* @ngInject */ function hotkeys($state, $injector, dispatchers, gettextCatalog, translator) { const I18N = translator(() => ({ OPEN_COMPOSER: gettextCatalog.getString('Open the composer', null, 'Hotkey description'), CREATE_REPLY: gettextCatalog.getString('Create a reply', null, 'Hotkey description'), CREATE_REPLY_ALL: gettextCatalog.getString('Create a reply all', null, 'Hotkey description'), FORWARD_MSG: gettextCatalog.getString('Forward the message', null, 'Hotkey description'), MARK_AS_READ: gettextCatalog.getString('Mark as read', null, 'Hotkey description'), MARK_AS_UNREAD: gettextCatalog.getString('Mark as unread', null, 'Hotkey description'), MOVE_TO_INBOX: gettextCatalog.getString('Move to inbox', null, 'Hotkey description'), MOVE_TO_TRASH: gettextCatalog.getString('Move to trash', null, 'Hotkey description'), MOVE_TO_ARCHIVE: gettextCatalog.getString('Move to archive', null, 'Hotkey description'), MOVE_TO_SPAM: gettextCatalog.getString('Move to spam', null, 'Hotkey description'), SHOW_HOTKEYS_LIST: gettextCatalog.getString('Show hotkeys available', null, 'Hotkey description'), GO_TO_INBOX: gettextCatalog.getString('Go to inbox', null, 'Hotkey description'), GO_TO_DRAFTS: gettextCatalog.getString('Go to drafts', null, 'Hotkey description'), GO_TO_SENT: gettextCatalog.getString('Go to sent', null, 'Hotkey description'), GO_TO_STARRED: gettextCatalog.getString('Go to starred', null, 'Hotkey description'), GO_TO_ARCHIVE: gettextCatalog.getString('Go to archive', null, 'Hotkey description'), GO_TO_SPAM: gettextCatalog.getString('Go to spam', null, 'Hotkey description'), GO_TO_TRASH: gettextCatalog.getString('Go to trash', null, 'Hotkey description'), SELECT_ALL: gettextCatalog.getString('Select all elements', null, 'Hotkey description'), UNSELECT_ALL: gettextCatalog.getString('Unselect all elements', null, 'Hotkey description') })); const KEY_EVENT_TYPE = { PRESS: 'keypress', DOWN: 'keydown', UP: 'keyup' }; const { dispatcher } = dispatchers([ 'composer.new', 'hotkeys', 'replyConversation', 'replyAllConversation', 'forwardConversation', 'selectElements', 'toggleStar', 'openMarked', 'selectMark', 'markPrevious', 'markNext', 'left', 'right', 'read', 'unread', 'move', 'newElement', 'oldElement' ]); const mousetrapInstance = new Mousetrap(); const action = (cb) => () => (cb(), false); const redirect = (state) => () => $state.go(state); const emit = (action, { type, data = {} } = {}) => () => { if (action === 'composer.new') { data.message = $injector.get('messageModel')(); } dispatcher[action](type, data); }; const openMarked = (event) => { dispatcher.openMarked(); // This function is bind to the Enter key, we need to prevent the // browser from executing the default action otherwise it will // trigger a click on the currently focused element. event.preventDefault(); }; const help = () => { const hotkeyModal = $injector.get('hotkeyModal'); hotkeyModal.activate({ params: { close() { hotkeyModal.deactivate(); } } }); return false; }; const goToInbox = action(redirect('secured.inbox')); const goToDrafts = action(redirect('secured.drafts')); const goToSent = action(redirect('secured.sent')); const goToStarred = action(redirect('secured.starred')); const goToArchive = action(redirect('secured.archive')); const goToSpam = action(redirect('secured.spam')); const goToTrash = action(redirect('secured.trash')); const composer = action( emit('composer.new', { type: 'new', data: {} }) ); const commandPalette = action(emit('hotkeys', { type: 'commandPalette' })); const save = action(emit('hotkeys', { type: 'save' })); const reply = action(emit('replyConversation')); const replyAll = action(emit('replyAllConversation')); const forward = action(emit('forwardConversation')); const selectAll = action(emit('selectElements', { type: 'all', data: { isChecked: true } })); const unselectAll = action(emit('selectElements', { type: 'all', data: { isChecked: false } })); const slash = action(emit('hotkeys', { type: 'slash' })); const toggleStar = action(emit('toggleStar')); const selectMark = action(emit('selectMark')); const markPrevious = action(emit('markPrevious')); const markNext = action(emit('markNext')); const escape = action(emit('hotkeys', { type: 'escape' })); const left = action(emit('left')); const right = action(emit('right')); const read = action(emit('read')); const unread = action(emit('unread')); const inbox = action(emit('hotkeys', { type: 'move', data: { to: 'inbox' } })); const trash = action(emit('hotkeys', { type: 'move', data: { to: 'trash' } })); const archive = action(emit('hotkeys', { type: 'move', data: { to: 'archive' } })); const spam = action(emit('hotkeys', { type: 'move', data: { to: 'spam' } })); const newElement = action(emit('newElement')); const oldElement = action(emit('oldElement')); const keys = [ { keyboard: 'c', callback: composer, description: I18N.OPEN_COMPOSER }, { keyboard: 'mod+s', callback: save, global: true }, { keyboard: 'shift+space', callback: commandPalette }, { keyboard: 'shift+r', callback: reply, description: I18N.CREATE_REPLY }, { keyboard: 'shift+a', callback: replyAll, description: I18N.CREATE_REPLY_ALL }, { keyboard: 'shift+f', callback: forward, description: I18N.FORWARD_MSG }, { keyboard: 'k', callback: newElement }, { keyboard: 'j', callback: oldElement }, { keyboard: 'enter', callback: openMarked }, { keyboard: 'r', callback: read, description: I18N.MARK_AS_READ, keyEventType: KEY_EVENT_TYPE.UP }, { keyboard: 'u', callback: unread, description: I18N.MARK_AS_UNREAD, keyEventType: KEY_EVENT_TYPE.UP }, { keyboard: '.', callback: toggleStar }, { keyboard: 'i', callback: inbox, description: I18N.MOVE_TO_INBOX, keyEventType: KEY_EVENT_TYPE.UP }, { keyboard: ['t', 'del', 'command+backspace'], callback: trash, description: I18N.MOVE_TO_TRASH, keyEventType: KEY_EVENT_TYPE.UP }, { keyboard: 'a', callback: archive, description: I18N.MOVE_TO_ARCHIVE, keyEventType: KEY_EVENT_TYPE.UP }, { keyboard: 's', callback: spam, description: I18N.MOVE_TO_SPAM, keyEventType: KEY_EVENT_TYPE.UP }, { keyboard: '?', callback: help, description: I18N.SHOW_HOTKEYS_LIST }, { keyboard: 'g i', callback: goToInbox, description: I18N.GO_TO_INBOX }, { keyboard: 'g d', callback: goToDrafts, description: I18N.GO_TO_DRAFTS }, { keyboard: 'g s', callback: goToSent, description: I18N.GO_TO_SENT }, { keyboard: 'g .', callback: goToStarred, description: I18N.GO_TO_STARRED }, { keyboard: 'g a', callback: goToArchive, description: I18N.GO_TO_ARCHIVE }, { keyboard: 'g x', callback: goToSpam, description: I18N.GO_TO_SPAM }, { keyboard: 'g t', callback: goToTrash, description: I18N.GO_TO_TRASH }, { keyboard: '* a', callback: selectAll, description: I18N.SELECT_ALL }, { keyboard: '* n', callback: unselectAll, description: I18N.UNSELECT_ALL }, { keyboard: 'x', callback: selectMark }, { keyboard: 'left', callback: left }, { keyboard: 'right', callback: right }, { keyboard: 'up', callback: markPrevious }, { keyboard: 'down', callback: markNext }, { keyboard: 'escape', callback: escape }, { keyboard: '/', callback: slash } ]; const removeBinding = ({ keyboard, keyEventType }) => mousetrapInstance.unbind(keyboard, keyEventType); const addBinding = ({ keyboard, callback, keyEventType, global = false }) => { if (global) { // 'keyup' will not work with command+s return mousetrapInstance.bindGlobal(keyboard, callback, keyEventType); } mousetrapInstance.bind(keyboard, callback, keyEventType); }; /** * Bind/unBind an action for an event based on a custom list * @param {Array} list [...<eventName>] * @param {Function} cb Action to perform * @return {void} */ const filterBinding = (list = [], cb = angular.noop) => { flow( filter(({ keyboard }) => _.includes(list, keyboard)), each(cb) )(keys); }; const hotkeys = { initialized: false, init(status = false) { // Don't unbind if we didn't bind before if (!this.initialized) { status && this.bind(); // Don't unbind if it's not required this.initialized = true; return; } this[status ? 'bind' : 'unbind'](); }, bind(list = []) { if (!list.length) { return [...keys].forEach(addBinding); } filterBinding(list, addBinding); }, unbind(list = []) { if (!list.length) { return [...keys].forEach(removeBinding); } filterBinding(list, removeBinding); }, trigger(...arg) { return mousetrapInstance.trigger(...arg); }, reset() { return mousetrapInstance.reset(); }, pause() { return mousetrapInstance.pause(); }, unpause() { return mousetrapInstance.unpause(); }, keys() { return [...keys]; }, translations(key) { return I18N[key] || I18N; } }; return hotkeys; } export default hotkeys; | Mid | [
0.546511627906976,
29.375,
24.375
] |
Jae C. Hong / AP Presidential hopeful Barack Obama tours the Chrysler Stamping Plant in Sterling Height, Michigan, on Wednesday, May 14. Are you currently wearing a flag pin? Yes? Then you love America. No? Hmm. That's gonna be a problem. Such was the false dichotomy that faced Barack Obama during his April 16 debate against Hillary Clinton, when Charlie Gibson asked Obama a voter question about why he did not wear a flag pin on his lapel. The previous October, an Iowa ABC reporter had asked him a similar question, to which Obama replied that he had worn one after 9/11, but soon noticed, "people wearing a lapel pin but not acting very patriotic." He went on to explain, "I decided I won't wear that pin on my chest. Instead I'm going to try to tell the American people what I believe... and hopefully that will be a testimony to my patriotism." Naturally, a controversy erupted. When it came up again during the April debate, he made a similar point. Obama now wears a flag pin on his lapel. Every day. Short of wearing a stars and stripes onesie, the flag lapel pin is the quickest sartorial method for a politician to telegraph his or her patriotism. The origin of the flag lapel pin is murky, though it is by necessity linked the history of the American flag as a commonly used symbol. According to Marc Leepson's Flag: An American Biography, the "near religious reverence many Americans have" for our national symbol dates only to the Civil War era (not back to the Revolutionary War, as many assume) . Prior to that, few private citizens possessed or flew their own flags it was limited to military and federal facilities. When the Confederates started winning battles early on in the War Between the States, Northerners began to fly the flag as a sign of pride. Since then, flag imagery has been intricately tied to moments of crisis or conflict. Over the past four decades, Kit Hinrichs, one of the nation's top graphic designers, has collected more than 5,000 pieces of stars and stripesrelated memorabilia. He says the flag lapel pins in his collection don't really date back before mid-century. "I don't think it was a common thing for men and women to wear before the Second World War," he says. "I certainly have jewelry from before then with flags on it cufflinks and stick pins and tuxedo buttons and brooches but not [many flag pins] before the '50s." It was during the culture wars of the late '60s and early '70s that the flag lapel pin truly took off and became the simultaneously uniting and divisive symbol that it is today. Republican candidates in the 1970 congressional race wore them as a symbol of patriotic solidarity against anti-Vietnam protesters like Abbie Hoffman who donned a shirt made of the flag or others who stitched the flag onto the seat of their pants. But it was Richard Nixon who brought the pin to national attention. According to Stephen E. Ambrose's biography Nixon, the President got the idea for sporting a lapel pin from his chief of staff, H.R. Haldeman, who had noticed a similar gesture in the Robert Redford film The Candidate. Nixon commanded all of his aides to go and do likewise. The flag pins were noticed by the public, and many in Nixon's supposed "silent majority" began to similarly sport flags on their lapels. Over the next few decades, the pin sporadically surged in popularity. During the Gulf War, they sold briskly alongside flag patches and yellow ribbons. Then came 9/11. Taking a page from the Nixon Administration, George W. Bush and his aides all donned pins. So did many anchors on Fox News, though not Bill O'Reilly, who said at the time "I'm just a regular guy. Watch me and you'll know what I think without wearing a pin." ABC News, on the other hand, prohibited its on-air reporters from pinning on the red, white, and blue, citing a desire to maintain journalistic credibility. As befits a tradition that reached its height during the Nixon years, flag lapel pins have fairly or not become to many a shibboleth of America's War on Terror, and a symbol of the "either you're with us or against us" ethos that has often prevailed since September 11, 2001. And while the country hasn't yet reached anything close to a consensus on what a flag pin says about its wearer, Barack Obama seems to have discovered that symbols matter even if one doesn't agree with the way they are used. | Mid | [
0.5634743875278391,
31.625,
24.5
] |
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