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58932,
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1918 pandemic exhibited a distinct pattern that has not been
documented before or since: a “W—shaped” curve, similar to
the familiar U-shaped curve but with the addition of a third
(middle) distinct peak of deaths in young adults z20410
years of age | 21,925 | 22,205 | [
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3618,
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12166,
273,
2579,
275,
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312,
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2887,
19584,
11576,
272,
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] | Influenza vaccination during pregnancy is safe, provides reasonable maternal protection against influenza, and also protects infants for a limited period from confirmed influenza infection (vaccine efficacy 63% in Bangladesh [63] and 50.4% in South Africa [64] ). However as antibody levels drop sharply after birth, infant protection does not persist much beyond 8 weeks | 19,437 | 19,808 | [
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] |
[
1830,
860,
2079,
2913,
646,
629,
275,
23076,
241,
6429,
1072,
3270,
278,
34,
89,
36,
42,
487,
2653,
4121,
277,
268,
10438,
275,
62855,
311,
49010,
273,
2254,
3752,
250,
257,
1482,
5955,
23476,
15157,
14510,
1542,
24290,
9133,
317,
34021,
272,
248,
7980,
438,
8414,
193,
193,
12659,
7561,
17794,
25,
17747,
6825,
25,
24084,
88,
25,
6298,
83,
25,
16162,
26,
4111,
78,
26,
34067,
26,
7141,
46,
38587,
56864,
33,
26,
193,
193,
40853,
37,
261,
27,
77,
28,
7427,
24564,
49757,
31,
77,
5831,
78,
38206,
34,
79,
5367,
78,
3668,
76,
38490,
30,
81,
34,
80,
39406,
30,
76,
193,
193,
43382,
37,
4389,
1264,
320,
5732,
24,
54,
20791,
23,
4666,
1317,
38,
46807,
318,
24,
11635,
6495,
23,
1848,
19295,
38,
531,
48465,
23,
4833,
80,
38,
7971,
81,
23,
27429,
38,
7971,
81,
23,
10777,
38,
17658,
327,
2710,
23,
24935,
38,
814,
320,
464,
5146,
23,
20529,
38,
1154,
340,
686,
23,
2641,
24,
48693,
38,
897,
1548,
23,
59483,
38,
28319,
14231,
23,
39073,
38,
337,
1670,
327,
87,
24,
7066,
524,
14231,
23,
31177,
38,
25111,
307,
44555,
23,
12116,
438,
193,
7499,
37,
204,
626,
32,
24,
3881,
24,
3739,
193,
40144,
37,
204,
696,
25,
19469,
28,
26,
35048,
25,
45707,
25,
24445,
58348,
31,
193,
34729,
37,
32067,
24,
1546,
193,
193,
12053,
37,
41569,
51834,
37,
2254,
3752,
250,
257,
304,
241,
31627,
8147,
273,
34925,
14625,
312,
248,
2820,
275,
13149,
7418,
13930,
18732,
11576,
25,
1130,
11576,
5229,
431,
23076,
6429,
362,
1764,
13998,
431,
11576,
335,
599,
13930,
17436,
248,
5777,
275,
241,
2005,
4630,
24,
40395,
9133,
14625,
335,
248,
25504,
4109,
44337,
22961,
504,
3534,
2879,
312,
248,
2820,
275,
13930,
11576,
25,
7947,
23,
248,
5777,
275,
248,
2005,
4630,
24,
40395,
9133,
4800,
62855,
311,
49010,
1774,
335,
953,
3752,
250,
257,
272,
241,
28313,
6742,
312,
919,
4121,
277,
268,
2859,
398,
16306,
272,
24,
13636,
290,
273,
272,
24,
97,
5299,
25,
8158,
45203,
3691,
2040,
378,
18839,
25409,
37,
703,
1049,
272,
24,
13636,
290,
325,
953,
3752,
250,
257,
273,
62855,
311,
49010,
714,
42318,
15157,
1542,
1988,
23076,
317,
6429,
20895,
204,
19,
51,
28,
57,
28,
19,
3614,
20,
91,
31942,
23,
370,
30,
57,
29,
23,
370,
32,
57,
28,
23,
370,
34,
57,
34,
691,
10299,
23,
360,
11021,
272,
241,
33262,
23076,
2308,
335,
241,
1958,
2895,
15824,
370,
34,
57,
34,
6429,
204,
19,
7035,
8285,
3236,
271,
248,
927,
715,
23076,
317,
19,
51,
34,
57,
36,
20,
6429,
20,
273,
241,
370,
28,
57,
28,
19,
3614,
20,
91,
31942,
23076,
6429,
272,
319,
5831,
14961,
26,
33,
14672,
325,
248,
6725,
745,
275,
1216,
15199,
6302,
7398,
11461,
275,
13275,
5632,
272,
8268,
335,
1216,
40443,
24,
1410,
1696,
424,
379,
28827,
25,
3848,
628,
1517,
23,
414,
4210,
304,
11131,
830,
635,
248,
2820,
5766,
510,
271,
204,
7428,
2155,
1106,
7228,
25,
9449,
38610,
2917,
37,
317,
31003,
9687,
9346,
953,
3752,
250,
257
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] | ion channel activity of the 3a protein | 1,006 | 1,044 | [
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27637,
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312,
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758,
2260,
13149,
1040,
18072,
42,
51,
384,
543,
36456,
272,
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31470,
273,
5690,
18067,
345,
40740,
11799,
26588,
193,
193,
12659,
7561,
17794,
25,
17747,
6825,
25,
24084,
88,
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6298,
83,
25,
16162,
26,
4111,
78,
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34067,
26,
7141,
46,
31407,
48120,
30,
26,
193,
193,
40853,
37,
293,
4531,
1313,
76,
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4821,
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1938,
761,
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81,
53597,
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18637,
49706,
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1452,
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81,
32989,
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43382,
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3177,
23,
11692,
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36608,
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465,
10763,
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34331,
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7499,
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40144,
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13164,
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34729,
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32067,
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1546,
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12053,
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390,
4902,
27768,
273,
292,
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357,
6021,
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35688,
2733,
267,
8009,
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3575,
2084,
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4141,
271,
13459,
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384,
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36456,
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14352,
41921,
100,
48150,
39324,
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4071,
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3558,
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314,
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59254,
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12925,
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648,
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1428,
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2465,
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2895,
15824,
312,
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2887,
19584,
11576,
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26758,
12905,
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31470,
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3783,
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2315,
13675,
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17303,
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1562,
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1042,
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31535,
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55531,
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17747,
6825,
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34067,
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12053,
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55531,
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53,
22083,
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65,
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16896,
1520,
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7217,
22083,
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418,
2887,
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4300,
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3381,
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31627,
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10036,
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3381,
61527,
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504,
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2879,
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398,
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61891,
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31535,
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1934,
313,
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13,
47343,
11112,
13,
18341,
26037,
5392,
273,
9479,
275,
13149,
23825,
10143,
3644,
313,
204,
9756,
24,
4878,
4468,
95,
2049,
13761,
23,
6139,
312,
1430,
12096,
275,
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32,
17436,
25,
390,
4027,
18341,
26037,
24,
10036,
11491,
271,
413,
2661,
37880,
273,
2712,
15135,
4354,
335,
248,
11301,
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against a highly infectious disease while maintaining function at a high volume capacity.
Keywords: Coronavirus, COVID-19, novel coronavirus pneumonia, infection control | 4,062 | 4,311 | [
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1,
1,
1
] | 79 % | 8,084 | 8,088 | [
0,
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] |
[
4479,
413,
331,
29,
24,
3039,
14810,
650,
33444,
42,
56,
1048,
37980,
23979,
1745,
335,
2737,
3919,
33435,
52060,
47733,
39198,
1494,
84,
24,
19465,
269,
59914,
28,
24,
1971,
34835,
522,
3286,
10334,
27521,
23494,
24,
29,
204,
19,
94,
56,
29,
20,
1435,
38512,
11059,
10500,
1542,
53654,
6663,
24290,
9133,
4365,
15266,
272,
60065,
45,
26,
78,
331,
474,
193,
193,
12659,
7561,
17794,
25,
17747,
6825,
25,
24084,
88,
25,
6298,
83,
25,
16162,
26,
4111,
78,
26,
34067,
26,
7141,
46,
43906,
51924,
29,
26,
193,
193,
40853,
37,
293,
7427,
76,
45840,
77,
42209,
33268,
9890,
36,
516,
40449,
2485,
469,
310,
6765,
761,
30,
80,
53213,
80,
36,
78,
27,
193,
193,
43382,
37,
41803,
43482,
1847,
23,
35137,
551,
25,
399,
14292,
11221,
23,
382,
2601,
38,
9486,
23,
51349,
24,
51,
2227,
38,
3134,
23,
2387,
24,
48,
369,
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9486,
23,
301,
6991,
24,
51,
8866,
38,
11799,
242,
316,
497,
23,
55316,
4675,
2188,
38,
703,
246,
41717,
76,
23,
60431,
7168,
38,
11958,
23,
1676,
24092,
38,
6578,
23,
370,
5783,
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24767,
38,
11640,
23,
1154,
1018,
24,
59,
10446,
38,
38584,
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11276,
24,
51,
1452,
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7986,
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43592,
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62,
443,
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23,
636,
338,
24,
16207,
515,
193,
7499,
37,
204,
626,
31,
24,
3519,
24,
3739,
193,
40144,
37,
204,
696,
25,
19469,
28,
26,
35048,
25,
45707,
25,
29650,
29527,
28,
193,
34729,
37,
32067,
24,
1546,
193,
193,
12053,
37,
1472,
1128,
241,
2899,
273,
3227,
24358,
37980,
9200,
1542,
2895,
15824,
23076,
17436,
23,
360,
13027,
62402,
52060,
47733,
39198,
1494,
84,
20895,
325,
5360,
55105,
13972,
6078,
204,
29,
335,
204,
19,
91,
2255,
44,
24,
4274,
44,
28,
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94,
56,
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26,
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1494,
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84,
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14594,
2307,
51662,
1072,
13953,
317,
28,
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4274,
44,
28,
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313,
248,
4418,
25,
390,
4418,
44775,
275,
248,
22474,
6078,
398,
18347,
431,
16236,
14758,
326,
16660,
23,
3365,
25138,
12415,
273,
9407,
1487,
11027,
33353,
48679,
25,
27295,
273,
31003,
42085,
5630,
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62402,
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84,
679,
14672,
11717,
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986,
3193,
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32251,
12838,
401,
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55861,
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24358,
37980,
18602,
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2071,
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38064,
326,
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14594,
2307,
51662,
1072,
13953,
317,
28,
20799,
520,
18289,
24358,
37980,
23,
1490,
7552,
273,
2324,
24,
39319,
10160,
9545,
25,
529,
241,
4671,
1318,
335,
204,
696,
13671,
47,
19,
1223,
20,
275,
317,
26,
4730,
26,
54,
50530,
26,
66,
18224,
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3881,
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51,
32,
57,
28,
770,
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17894,
25535,
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1811,
6002,
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66,
10587,
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57,
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1811,
6002,
26,
54,
50530,
26,
66,
3828,
26,
853,
32,
19,
51,
34,
57,
30,
770,
273,
317
] | [
1,
1,
1,
1,
1,
1,
1,
1,
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1,
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1,
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1,
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1,
1,
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1,
1,
1,
1,
1,
1,
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1,
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1,
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1,
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1,
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1,
1,
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1,
1,
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1,
1,
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1,
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1,
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1,
1,
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1,
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1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
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1,
1,
1,
1,
1,
1,
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1,
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1,
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1,
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1,
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1,
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1,
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1,
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1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1
] | low immunogenicity | 3,384 | 3,402 | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
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5261,
30985,
275,
248,
462,
13991,
24,
22270,
25935,
20081,
25,
9706,
23,
272,
241,
11378,
6077,
11558,
2220,
23,
9407,
60026,
27709,
3193,
646,
16306,
272,
9041,
427,
204,
10208,
1770,
204,
19,
63846,
32,
909,
24,
693,
20,
34478,
335,
13149,
273,
26,
252,
23857,
1986,
24,
36296,
1250,
23964,
25,
8743,
1306,
23,
2369,
248,
204,
10208,
2913,
275,
23964,
23,
2634,
335,
6935,
7697,
24,
10965,
2885,
618,
6302,
2712,
204,
19,
30,
25,
33,
24,
14801,
20,
19003,
5894,
24,
696,
3193,
661,
1014,
335,
241,
2278,
12096,
204,
19,
59,
204,
40,
204,
27,
25,
4328,
770,
273,
646
] | [
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1,
1,
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1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1
] | Chi-square test and Fisher's exact test | 29,985 | 30,024 | [
0,
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] |
[
1562,
64379,
204,
1739,
1096,
275,
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61645,
5086,
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24290,
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30497,
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10380,
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35,
34021,
23,
6110,
431,
17294
] | [
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] | 2 major descendant lineages of the 1918
H1N1 Virus, as well as 2 additional reassortant lineages,
persist naturally: a human epidemic/endemic H1N1 line-
age, a porcine enzootic H1N1 lineage (so-called classic
swine flu), and the reassorted human H3N2 Virus lineage,
which like the human H1N1 Virus, has led to a porcine
H3N2 lineage. | 3,271 | 3,603 | [
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271
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] | in February | 5,646 | 5,657 | [
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272,
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26724,
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15623,
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3035,
43031,
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] |
Subsets and Splits